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7 results on '"Bak, Jitske"'

1. Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

Author

Mossink, Britt, van Rhijn, Jon-Ruben, Wang, Shan, Linda, Katrin, Vitale, Maria R., Zöller, Johanna E. M., van Hugte, Eline J. H., Bak, Jitske, Verboven, Anouk H. A., Selten, Martijn, Negwer, Moritz, Latour, Brooke L., van der Werf, Ilse, Keller, Jason M., Klein Gunnewiek, Teun M., Schoenmaker, Chantal, Oudakker, Astrid, Anania, Alessia, Jansen, Sophie, Lesch, Klaus-Peter, Frega, Monica, van Bokhoven, Hans, Schubert, Dirk, and Nadif Kasri, Nael

Published
2022
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2. Decoding microtubule detyrosination: enzyme families, structures, and functional implications.

Author

Bak, Jitske, Brummelkamp, Thijn R., and Perrakis, Anastassis

Subjects
*CYTOSKELETON, *MICROTUBULES, *TYROSINE, *DIMERS, *ENZYMES, *TUBULINS
Abstract

Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of the C-terminal tyrosine of a-tubulin on assembled microtubules and the re-ligation of tyrosine on detyrosinated tubulin dimers. This modification cycle has been implicated in cardiac disease, neuronal development, and mitotic defects. The vasohibin and microtubule-associated tyrosine carboxypeptidase enzyme families are responsible for microtubule detyrosination. Their long-sought discovery allows to review and summarise differences and similarities between the two enzymes families and discuss how they interplay with other modifications and functions of the tubulin code. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Posttranslational modification of microtubules by the MATCAP detyrosinase

Author

Landskron, Lisa, Bak, Jitske, Adamopoulos, Athanassios, Kaplani, Konstantina, Moraiti, Maria, van den Hengel, Lisa G., Song, Ji Ying, Bleijerveld, Onno B., Nieuwenhuis, Joppe, Heidebrecht, Tatjana, Henneman, Linda, Moutin, Marie Jo, Barisic, Marin, Taraviras, Stavros, Perrakis, Anastassis, Brummelkamp, Thijn R., Landskron, Lisa, Bak, Jitske, Adamopoulos, Athanassios, Kaplani, Konstantina, Moraiti, Maria, van den Hengel, Lisa G., Song, Ji Ying, Bleijerveld, Onno B., Nieuwenhuis, Joppe, Heidebrecht, Tatjana, Henneman, Linda, Moutin, Marie Jo, Barisic, Marin, Taraviras, Stavros, Perrakis, Anastassis, and Brummelkamp, Thijn R.

Abstract

The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of a-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The vasohibin–small vasohibin-binding protein (SVBP) complex underlies much, but not all, detyrosination. We used haploid genetic screens to identify an unannotated protein, microtubule associated tyrosine carboxypeptidase (MATCAP), as a remaining detyrosinating enzyme. X-ray crystallography and cryo–electron microscopy structures established MATCAP’s cleaving mechanism, substrate specificity, and microtubule recognition. Paradoxically, whereas abrogation of tyrosine religation is lethal in mice, codeletion of MATCAP and SVBP is not. Although viable, defective detyrosination caused microcephaly, associated with proliferative defects during neurogenesis, and abnormal behavior. Thus, MATCAP is a missing component of the detyrosination-tyrosination cycle, revealing the importance of this modification in brain formation.

Published
2022

5. Posttranslational modification of microtubules by the MATCAP detyrosinase

Author

Landskron, Lisa, primary, Bak, Jitske, additional, Adamopoulos, Athanassios, additional, Kaplani, Konstantina, additional, Moraiti, Maria, additional, van den Hengel, Lisa G., additional, Song, Ji-Ying, additional, Bleijerveld, Onno B., additional, Nieuwenhuis, Joppe, additional, Heidebrecht, Tatjana, additional, Henneman, Linda, additional, Moutin, Marie-Jo, additional, Barisic, Marin, additional, Taraviras, Stavros, additional, Perrakis, Anastassis, additional, and Brummelkamp, Thijn R., additional

Published
2022
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6. Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

Author

Mossink, Britt, primary, van Rhijn, Jon-Ruben, additional, Wang, Shan, additional, Linda, Katrin, additional, Vitale, Maria R., additional, Zöller, Johanna E. M., additional, van Hugte, Eline J. H., additional, Bak, Jitske, additional, Verboven, Anouk H. A., additional, Selten, Martijn, additional, Negwer, Moritz, additional, Latour, Brooke L., additional, van der Werf, Ilse, additional, Keller, Jason M., additional, Klein Gunnewiek, Teun M., additional, Schoenmaker, Chantal, additional, Oudakker, Astrid, additional, Anania, Alessia, additional, Jansen, Sophie, additional, Lesch, Klaus-Peter, additional, Frega, Monica, additional, van Bokhoven, Hans, additional, Schubert, Dirk, additional, and Nadif Kasri, Nael, additional

Published
2021
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7. Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks

Author

Mossink, Britt, primary, van Rhijn, Jon-Ruben, additional, Wang, Shan, additional, van Hugte, Eline J. H., additional, Linda, Katrin, additional, Bak, Jitske, additional, Verboven, Anouk H. A., additional, Selten, Martijn, additional, Anania, Alessia, additional, Jansen, Sophie, additional, Keller, Jason M., additional, Gunnewiek, Teun Klein, additional, Schoenmaker, Chantal, additional, Oudakker, Astrid, additional, Frega, Monica, additional, van Bokhoven, Hans, additional, Schubert, Dirk, additional, and Kasri, Nael Nadif, additional

Published
2020
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