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1. Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines

Author

Sørensen, T.M., Scahill, K., Ruperez, J. Espinel, Olejnik, M., Swinbourne, F., Verwilghen, D.R., Nolff, M.C., Baines, S., Marques, C., Vilen, A., Duarte, E.L., Dias, M., Dewulf, S., Wichtowska, A., Valencia, A. Carranza, Pelligand, L., Broens, E.M., Toutain, P.L., Alishani, M., Brennan, M.L., Weese, J.S., Jessen, L.R., and Allerton, F.

Published
2024
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3. Magnetic monopole search with the full MoEDAL trapping detector in 13 TeV $pp$ collisions interpreted in photon-fusion and Drell-Yan production

Author

MoEDAL Collaboration, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Bevan, A., Branzas, H., Campbell, M., Cecchini, S., Cho, Y. M., de Montigny, M., De Roeck, A., Ellis, J. R., Sawy, M. El, Fairbairn, M., Felea, D., Frank, M., Hays, J., Hirt, A. M., Janecek, J., Kim, D. -W., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Levi, G., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mieskolainen, M., Millward, L., Mitsou, V. A., Orava, R., Ostrovskiy, I., Papavassiliou, J., Parker, B., Patrizii, L., Păvălaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., de Austri, R. Ruiz, Sahnoun, Z., Sakellariadou, M., Santra, A., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Staelens, M., Suk, M., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Wall, A., and Zgura, I. S.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

MoEDAL is designed to identify new physics in the form of stable or pseudostable highly ionizing particles produced in high-energy Large Hadron Collider (LHC) collisions. Here we update our previous search for magnetic monopoles in Run 2 using the full trapping detector with almost four times more material and almost twice more integrated luminosity. For the first time at the LHC, the data were interpreted in terms of photon-fusion monopole direct production in addition to the Drell-Yan-like mechanism. The MoEDAL trapping detector, consisting of 794 kg of aluminum samples installed in the forward and lateral regions, was exposed to 4.0 fb$^{-1}$ of 13 TeV proton-proton collisions at the LHCb interaction point and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to or above the Dirac charge are excluded in all samples. Monopole spins 0, 1/2 and 1 are considered and both velocity-independent and -dependent couplings are assumed. This search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge., Comment: 7 pages REVTeX 4, 11 figures, 1 table, matches published version in Physical Review Letters

Published
2019
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4. Monopole production via photon fusion and Drell-Yan processes: MADGRAPH implementation and perturbativity via velocity-dependent coupling and magnetic moment as novel features

Author

Baines, S., Mavromatos, N. E., Mitsou, V. A., Pinfold, J. L., and Santra, A.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

In this work we consider point-like monopole production via photon-fusion and Drell-Yan processes in the framework of an effective U(1) gauge field theory obtained from conventional models describing the interaction of spin 0, 1/2, 1 magnetically-charged fields with ordinary photons, upon electric-magnetic dualisation. We present arguments based on such dualities which support the conjecture of an effective monopole-velocity-dependent magnetic charge. For the cases of spin-1/2 and spin-1 monopoles, we also include a magnetic-moment term kappa, which is treated as a new phenomenological parameter and, together with the velocity-dependent coupling, allows for a perturbative treatment of the cross-section calculation. We discuss unitarity issues within these effective field theories, in particular we point out that in the spin-1 monopole case only the value kappa=1 may restore unitarity. However from an effective-field-theory point of view, this lack of unitarity should not be viewed as an impediment for the phenomenological studies and experimental searches of generic spin-1 monopoles, given that the potential appearance of new degrees of freedom in the ultraviolet completion of such models might restore it. The second part of the paper deals with an appropriate implementation of photon-fusion and Drell-Yan processes based on the above theoretical scenarios into MADGRAPH UFO models, aimed to serve as a useful tool in interpretations of monopole searches at colliders such as LHC, especially for photon fusion, given that it has not been considered by experimental collaborations so far. Moreover, the experimental implications of such perturbatively reliable monopole searches have been laid out., Comment: 43 pages, 32 figures; two plots corrected in fig.27 according to erratum EPJC(2019)79:166; no effect on conclusions

Published
2018
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5. Search for magnetic monopoles with the MoEDAL forward trapping detector in 2.11 fb$^{-1}$ of 13 TeV proton-proton collisions at the LHC

Author

MoEDAL Collaboration, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Bevan, A., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., de Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Frank, M., Frekers, D., Garcia, C., Hays, J., Hirt, A. M., Janecek, J., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Levi, G., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Ostrovskiy, I., Parker, B., Patrizii, L., Păvălaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., de Austri, R. Ruiz, Sahnoun, Z., Sakellariadou, M., Santra, A., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Widom, A., Willems, G., Yoon, J. H., and Zgura, I. S.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222~kg of aluminium samples, was exposed to 2.11~fb$^{-1}$ of 13 TeV proton-proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell-Yan production models for monopoles with spins 0, 1/2 and 1: in addition to standard point-like couplings, we also consider couplings with momentum-dependent form factors. The search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge., Comment: 8 pages, 5 figures, 1 table, accepted for publication in Phys. Lett. B

Published
2017
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6. Search for magnetic monopoles with the MoEDAL forward trapping detector in 13 TeV proton-proton collisions at the LHC

Author

MoEDAL Collaboration, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., de Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Flores, J., Frank, M., Frekers, D., Garcia, C., Hirt, A. M., Janecek, J., Kalliokoski, M., Katre, A., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Parker, B., Pasqualini, L., Patrizii, L., Păvălaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., de Austri, R. Ruiz, Sahnoun, Z., Sakellariadou, M., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Whyntie, T., Widom, A., Willems, G., Yoon, J. H., and Zgura, I. S.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

MoEDAL is designed to identify new physics in the form of long-lived highly-ionising particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC run-1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV $pp$ collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge., Comment: 6 pages, 1 table, 2 figures, accepted for publication in Phys. Rev. Lett

Published
2016
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9. Introduction : Co-creation and the 'sandcastle' problem

Author

Baines, S., Wilson, R., Fox, C., Narbutaité Aflaki, Inga, Bassi, A., Aramo-Immonen, H., Prandini, R., Baines, S., Wilson, R., Fox, C., Narbutaité Aflaki, Inga, Bassi, A., Aramo-Immonen, H., and Prandini, R.

Published
2024

11. Canine cutaneous histiocytoma : characterisation of a dendritic cell tumour

Author

Baines, S. J.

Subjects
636.089
Abstract

Canine cutaneous histiocytoma (CCH) is a common, benign tumour of dendritic cells (DCs). This tumour undergoes an early period of rapid growth over one to four weeks, followed by spontaneous regression, in most cases, over the next one to three months. Regression is associated with the influx of CD8+ T lymphocytes. The research in this thesis aimed to identify the state of differentiation of the neoplastic cells and to identify if they matched DC parameters on the basis of morphology, phenotype and function. Neoplastic dendritic cells isolated from excised tumours had a monocytoid appearance on light microscopy. On electron microscopy, the predominant cell morphology was monocytoid, but a greater proportion of cells with dendritic morphology were seen in lesions undergoing regression. Flow cytometry analysis of CCH cells revealed expression of CD1a, CD1c, CD11a, CD11c, CD18, CD45, CD45R, MHC-I, MHC-II and E-cadherin, confirming their Langerhans cell origin. In addition, the cells also showed uniform expression of CD1b, and expressed CD11b, CD44, CD49d and ICAM-I, consistent with an activated phenotype. CCH cells isolated from lesions undergoing regression had a higher level of expression of MHC-I, MHC-II and ICAM-1 compared with those cells isolated from early lesions. Immunohistochemical staining for MHC-II revealed that tumour cells from the early stage showed predominantly focal juxtanuclear staining, whereas those from regressing lesions showed mainly diffuse cytoplasmic staining. This is consistent with the hypothesis that CCH cells isolated from lesions in the early proliferative phase represent immature dendritic cells and CCH cells isolated from lesions in the regressing phase represent mature DCs. The CCH cells induced a strong proliferative response to the allogenic and autologous mixed lymphocyte reaction, consistent with their dendritic cell origin. When compared according to clinical stage of the lesion, CCH cells isolated from later lesions resulted in a greater proliferative response for a given number of stimulator cells than CCH cells isolated from early lesions. CCH cells exhibited a high rate of macropinocytosis as expected for cells of the myeloid/dendritic lineage. CCH cells from later lesions showed a significantly higher rate of macropinocytosis than those from early lesions. Macropinocytosis was down-regulated on culture of the cells.

Published
2002

14. Endoscopic treatment of acute oropharyngeal stick injuries in dogs: 46 cases (2010‐2020).

Author

Kilduff‐Taylor, A. and Baines, S. J.

Subjects
DOGS, DOG bites, VETERINARIANS, SYMPTOMS, WOUNDS & injuries, ENDOSCOPES
Abstract

Objectives: To review long‐term outcomes of dogs with acute oropharyngeal stick injuries managed with rigid endoscopy at a UK referral centre. Materials and Methods: Retrospective analysis and follow‐up with referring veterinary surgeons and owners of patients treated between 2010 and 2020. A medical record search was performed and data regarding signalment, clinical presentation, treatment and long‐term outcomes were recorded. Results: Sixty‐six dogs with acute oropharyngeal stick injury were identified and 46 (70.0%) of these had endoscopy of the wound. The dogs were of various breeds, ages (median=3 years; range 0.6 to 11 years) and weights (median=20.4 kg; range 7.7 to 38.4 kg) and 58.7% of patients were male. The median time from injury to referral was 1 day (range 2 hours to 7 days). Patients were anaesthetised, and injury tracts were explored using 0° and 30° forward‐oblique, 2.7 mm diameter, 18 cm length rigid endoscopes with a corresponding 14.5 French sheath using saline infusion via gravity. All foreign material that could be grasped was removed using forceps. Tracts were flushed with saline and reinspected to confirm removal of all visible foreign material. Out of 40 dogs with long‐term follow‐up, 38 (95.0%) had no major long‐term complications. The remaining two dogs developed cervical abscessation after endoscopy, one of which resolved after repeat endoscopy and the other resolved after open surgery. Clinical Significance: Long‐term follow‐up of dogs with acute oropharyngeal stick injury managed with rigid endoscopy showed an excellent outcome in 95.0% of cases. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Adapted guided self-help booklets for supporting the well-being of people with intellectual disabilities during the COVID-19 pandemic: an evaluation of impact

Author

Maguire, R, Pert, C, Baines, S, Gillooly, A, Hastings, RP, Hatton, C, Dagnan, D, Jahoda, A, Maguire, R, Pert, C, Baines, S, Gillooly, A, Hastings, RP, Hatton, C, Dagnan, D, and Jahoda, A

Abstract

Purpose: The COVID-19 pandemic meant that it became impossible for many individuals with intellectual disability to access specialist mental health support. The purpose of this study was to evaluate a set of guided self-help resources adapted for delivery on an outreach basis. Design/methodology/approach: The use and impact of the resources were evaluated through: data about downloads and requests for printed materials; interviews with individuals who used the resources; webinars with organisations; family members and support workers who had delivered the resources and an online survey with individuals who had delivered the resources. Findings: The resources had considerable reach, with over 12,555 printed copies requested from across Scotland. The materials were perceived to be relevant and useful, helping individuals to talk about difficulties and to be aware that others were facing similar challenges. Originality/value: The findings highlight the potential long-term value of guided self-help resources to help promote well-being that can be delivered on an outreach basis by family members and social care organisations.

Published
2022

20. Description and outcome of dogs with primary immune‐mediated polyarthritis: 73 cases (2012‐2017).

Author

Ravicini, S., Kent, A., Dunning, M., Baines, S., Clarke, S., and Allerton, F.

Subjects
DOGS, DISEASE relapse, BIOMEDICAL materials, IMMUNOSUPPRESSIVE agents, MAST cell tumors, SYMPTOMS
Abstract

Objectives: To provide a description of primary idiopathic immune‐mediated polyarthritis, including long‐term outcome and relapse rates, for dogs starting treatment with corticosteroids alone or corticosteroids with a second immunosuppressant. Materials and Methods: Medical records were reviewed between January 2012 and December 2017 to identify dogs diagnosed with primary immune‐mediated polyarthritis. Data including signalment, clinicopathological findings, type and duration of treatment, relapse and outcome were recorded. Results: Seventy‐three dogs were included. Fifty‐four dogs were started on corticosteroid monotherapy (an additional immunosuppressant was introduced later in 27/54 dogs) and 19 dogs were treated with multi‐modal immunosuppression from the outset. Ninety‐five percent (69/73) of dogs responded favourably to therapy although death was attributed to immune‐mediated polyarthritis in 19% (14/73) of dogs. Relapse of clinical signs was reported in 53% (39/73) dogs (31/39 while on treatment), with multiple relapses observed in 17 dogs. Complete cure (permanent withdrawal of immunosuppressive medication) was achieved in 46 dogs (63%). Overall, 81% of dogs had a well‐managed disease for an extended timeframe (≥1131 days). Fourteen of 19 (74%) dogs that started treatment with multi‐modal immunosuppression and 32 of 54 (59%) started on corticosteroids alone achieved a complete cure. Clinical Significance: This study provides extended follow‐up information for a large cohort of dogs with primary immune‐mediated polyarthritis. Immunosuppressive therapy was discontinued in the majority of dogs but disease‐associated mortality remains high. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Outcome of caudal superficial epigastric axial pattern flaps in dogs and cats: 70 cases (2007‐2020)

Author

Forster, K., primary, Cutando, L. S., additional, Ladlow, J., additional, Anderson, D., additional, Burton, C., additional, Das, S., additional, Gibson, S., additional, Kulendra, N., additional, Emmerson, T., additional, Baines, S., additional, Rutherford, L., additional, Paulino, R. D., additional, Fontanini, R., additional, Compagnone, K., additional, and De La Puerta, B., additional

Published
2021
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34. Search for magnetic monopoles with the MoEDAL forward trapping detector in 2.11 fb−1 of 13 TeV proton–proton collisions at the LHC

Author

Acharya, B, Alexandre, J, Baines, S, Benes, P, Bergmann, B, Bernabéu, J, Bevan, A, Branzas, H, Campbell, M, Caramete, L, Cecchini, S, de Montigny, M, De Roeck, A, Ellis, J, Fairbairn, M, Felea, D, Frank, M, Frekers, D, Garcia, C, Hays, J, Hirt, A, Janecek, J, Kim, D, Kinoshita, K, Korzenev, A, Lacarrère, D, Lee, S, Leroy, C, Levi, G, Lionti, A, Mamuzic, J, Margiotta, A, Mauri, N, Mavromatos, N, Mermod, P, Mitsou, V, Orava, R, Ostrovskiy, I, Parker, B, Patrizii, L, Păvălaş, G, Pinfold, J, Popa, V, Pozzato, M, Pospisil, S, Rajantie, A, Ruiz de Austri, R, Sahnoun, Z, Sakellariadou, M, Santra, A, Sarkar, S, Semenoff, G, Shaa, A, Sirri, G, Sliwa, K, Soluk, R, Spurio, M, Srivastava, Y, Suk, M, Swain, J, Tenti, M, Togo, V, Tuszyński, J, Vento, V, Vives, O, Vykydal, Z, Widom, A, Willems, G, Yoon, J, Zgura, I, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Bevan, A., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., de Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Frank, M., Frekers, D., Garcia, C., Hays, J., Hirt, A. M., Janecek, J., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Levi, G., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Ostrovskiy, I., Parker, B., Patrizii, L., Păvălaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., Ruiz de Austri, R., Sahnoun, Z., Sakellariadou, M., Santra, A., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Widom, A., Willems, G., Yoon, J. H., Zgura, I. S., Acharya, B, Alexandre, J, Baines, S, Benes, P, Bergmann, B, Bernabéu, J, Bevan, A, Branzas, H, Campbell, M, Caramete, L, Cecchini, S, de Montigny, M, De Roeck, A, Ellis, J, Fairbairn, M, Felea, D, Frank, M, Frekers, D, Garcia, C, Hays, J, Hirt, A, Janecek, J, Kim, D, Kinoshita, K, Korzenev, A, Lacarrère, D, Lee, S, Leroy, C, Levi, G, Lionti, A, Mamuzic, J, Margiotta, A, Mauri, N, Mavromatos, N, Mermod, P, Mitsou, V, Orava, R, Ostrovskiy, I, Parker, B, Patrizii, L, Păvălaş, G, Pinfold, J, Popa, V, Pozzato, M, Pospisil, S, Rajantie, A, Ruiz de Austri, R, Sahnoun, Z, Sakellariadou, M, Santra, A, Sarkar, S, Semenoff, G, Shaa, A, Sirri, G, Sliwa, K, Soluk, R, Spurio, M, Srivastava, Y, Suk, M, Swain, J, Tenti, M, Togo, V, Tuszyński, J, Vento, V, Vives, O, Vykydal, Z, Widom, A, Willems, G, Yoon, J, Zgura, I, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Bevan, A., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., de Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Frank, M., Frekers, D., Garcia, C., Hays, J., Hirt, A. M., Janecek, J., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Levi, G., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Ostrovskiy, I., Parker, B., Patrizii, L., Păvălaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., Ruiz de Austri, R., Sahnoun, Z., Sakellariadou, M., Santra, A., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Widom, A., Willems, G., Yoon, J. H., and Zgura, I. S.

Abstract

We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The MoEDAL forward trapping detector, comprising 222 kg of aluminium samples, was exposed to 2.11 fb−1 of 13 TeV proton–proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell–Yan production models for monopoles with spins 0, 1/2 and 1: in addition to standard point-like couplings, we also consider couplings with momentum-dependent form factors. The search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge.

Published
2018

36. Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

Author

Pettigrew, MM, Giulieri, SG, Guerillot, R, Kwong, JC, Monk, IR, Hayes, AS, Daniel, D, Baines, S, Sherry, NL, Holmes, NE, Ward, P, Gao, W, Seemann, T, Stinear, TP, Howden, BP, Pettigrew, MM, Giulieri, SG, Guerillot, R, Kwong, JC, Monk, IR, Hayes, AS, Daniel, D, Baines, S, Sherry, NL, Holmes, NE, Ward, P, Gao, W, Seemann, T, Stinear, TP, and Howden, BP

Abstract

Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections; however, mec gene-independent resistance adaptation can cause treatment failure. Despite its clinical relevance, the basis of this phenomenon remains poorly understood. Here, we investigated the genomic adaptation to oxacillin at an unprecedented scale using a large collection of 503 clinical mec-negative isolates and 30 in vitro-adapted isolates from independent oxacillin exposures. By combining comparative genomics, evolutionary convergence, and genome-wide association analysis, we found 21 genetic loci associated with low-level oxacillin resistance, underscoring the polygenic nature of this phenotype. Evidence of adaptation was particularly strong for the c-di-AMP signal transduction pathways (gdpP and dacA) and in the clpXP chaperone-protease complex. The role of mutations in gdpP in conferring low-level oxacillin resistance was confirmed by allele-swapping experiments. We found that resistance to oxacillin emerges at high frequency in vitro (median, 2.9 × 10-6; interquartile range [IQR], 1.9 × 10-6 to 3.9 × 10-6), which is consistent with a recurrent minimum inhibitory concentration (MIC) increase across the global phylogeny of clinical isolates. Nevertheless, adaptation in clinical isolates appears sporadically, with no stably adapted lineages, suggesting a high fitness cost of resistance, confirmed by growth assessment of mutants in rich media. Our data provide a broader understanding of the emergence and dynamics of oxacillin resistance adaptation in S. aureus and a framework for future surveillance of this clinically important phenomenon.IMPORTANCE The majority of Staphylococcus aureus strains causing human disease are methicillin-susceptible (MSSA) and can be treated with antistaphylococcal penicillins (such as oxacillin). While acquisition of the mec gene represents the main resistance mecha

Published
2020

37. Acknowledgement to reviewers of social sciences in 2019

Author

Abbas, A., Abel, G., Abreu, A., Adam, A., Adamek, M., Adiletta, G., Adusei-asante, K.A., Romeo, M.D.M., Alderson, A., Alfaro, E., Aliverti, A., Almeida, Fernando, Álvarez-gonzález, L.I., Amelina, A., Anand, C., Anderson, G., Andreasson, J., Ang, I., Aragon, J., Arcidiacono, C., Arcuri, S., Assante, D., Atukeren, E., Avery, H., Ayeb-karlsson, S., Azadi, H., Bachman, R., Bader, M., Badulescu, A., Bahmanteymouri, E., Baines, S., Baker, T., Baker‐beall, C., Bañón, L., Bar‐am, N., Barbier‐greenland, K., Barnett, R., Barragán‐escandón, A., Barreto, A.M., Barrett, E., Bartkowski, J., Bartram, R., Bartzas, G., Bates, D., Baviera‐puig, A., Bayley, A., Beazley, H., Beer, C., Behr, H., Beier, G., Belford, N., Bencivenga, R., Benli, A.E., Benton‐short, L., Berei, J.M., Berbel‐pineda, E., Bernstein, Berntzen, E.R., Bertella, L., Birney, G., Bittle, M., Black, S., Rivero, L.B., Blattner, J.J., Blok, C., Blount, A., Boas, Y., Bockarie, I., Bockerman, A., Bodén, P., Bönisch‐brednich, L., Bontje, B., Bontje, M., Borsellino, V., Bostan, I., Bowl, M., Bowman, B., Bracci, E., Bracken, C.M., Bradley, H., Brereton, P., Brewer, J., Bridge, D., Brooks, S., Brown, Andrijana, Brzoska, M., Brzozowski, W., Buckley, G., Buente, W., Bullaro, G.R., Burke, M.D., Burlacu, S., Busu, M., Butler, S., Byrne, J., Cabral, L., Cai, Y., Cajias, M., Calin, A.C., Callegari, C., Camarero, M., Campbell-figuerola, H., Campbell, J.R., Cannito, M., Canonico, E., Canosa, A., Carabelli, G., Carlbom, A., Carlone, T., Caron, R., Carpenter, A., Caruso, G., Casais, B., Castro, M.P., Cava, M.-J., Čeněk, J., Cerchione, R., Certomà, C., Chan, E., Charles, D., Charlwood, A., Chatzifotiou, S., Chell, K., Chen, L., Chen, Q., Chen, W.-J., Ching, L., Christensen, J., Ciasullo, M.V., Cimermanová, I., Činčera, J., Cipollina, M., Clutterbuck, R., Cochrane, B., Collin, K., Conley, R., Connell, H., Connelly, J., Connelly, L., Connelly, R., Conti, D., Conversi, D., Conway, G., Cooper, S., Cope, M., Corsini, F., Cristian, P., Crohn, H.M., Croog, R.C., Salazar, T., Csiszár, C., D’auria, I., D’souza, A., D’souza, N., Dabija, D.-C., Dagg, J., Dalby, S., DaleDalsgård, B., Dʹamato, A.L., Daniel, D., Dant, L., Dantas, C., Darwin, H., Dashper, K., David, M.E., De Flippo, D., De, A., Edi, M., Velázquez, E.D.C., Velázquez, F., Del Vecchio, P., Delatolla, A., Delgado, P., Delgado‐romero, E., Delrosso, J., Desimone, J., Detlefsen, L., Devaney, C., Díaz, L.M., Didham, R., Diogo, E., Dirakis, A., Doberneck, D., Doidge, M.D., Molero, G., Dombrowski, P.J., Doñate, C., Đorđević, Martín, Reis, P.G.R., Doucek, P., Dundes, L., Dvouletý, O., Dybo, T., Eastman, J., Eckhardt, J., Economou, A., Edler, D., Edu, U., Ekblom, P.E., Khaled, D., Ellis, C., Elsabry, E., Erceg, A., Erokhin, V., Ertz, M., Everitt, J., Evers, A., Falcone, P.M.F., Cabana, P., Fawcett, B., Fearnley, B., Featherstone, M., Ferreira, M., Ferreira, P., Fetner, T., Fisher, J., Fisher, R., Fitzpatrick, T., Flanagan, C., Fogarty, E.A., Fonchingong, C.C., Fontana, M., Fook, J., Foreman, A.M., Foster‐mcgregor, N., Fox, S., Franco, J.A., Franklin, A.L., Friedrich, T., Fromm, I., Fu, N., Fucà, R., Fukuda, Y., Fusco, G., Gabriela, D., Galan, D., Gamo, A., Galiano, J., Garcia, A., García, M.E.A., García‐germán, S., García‐machado, J.J., García‐ruiz, C.R., Gavini, M., Gazzano, A., Gebhardt, M., Gerson, S., Gherghina, Ş.C., Gibbs, P., Gilhooly, D., Gill, F., Gill, N., Gil‐lopez, A.J., Ginès Fabrellas, A., Giuffrida, N., Giuliani, G., Goddard, J., Godderis, R., Goh, C.S., Gomes, O., Goncharuk, A.G., Canche, M.G., Pérez, I.G., Valero, G., González, R.C.L., Gonzalez‐benson, O., Gonzalez‐feliu, J., González‐lópez, M., Gozdziak, E., Granx, B., Gran, R., Gray, S.L., Grbes, A., Grondys, K., Grugan, S., Guenther, J., Guijarro, F., Gurko, T., Haas, L.L., Hagellx, A., Hagell, H., Hallgrímsdóttir, H., Hamada, T., Hanf, J., Hannouf, M., Hao, F., Harman, G., Harris, K.L., Harris, R., Harrison, N.H., Healy, G., Healy, K., Heikkilä, E., Hellmich, C., Henig, J., Henninger, C.E., Heo, W., Herman, C., Herrero‐diz, P., Heyman, J., Hibbert, N., Hillman, A.L., Hillman, B., Hine, B., Hino, K., Hinten, M., Hipp, L., Hoang, D., Holleran, D., Hollin, I., Holm, M., Holmes, C., Hook, G., Hoornweg, D., Hopper, L., Hossain, M., Hoxhaj, R., Hu, B., Huang, Y., Huarita, E., Hudec, O., Humbert, A.L., Hung, M.-C., Hunt, A., Husu, L., IanoleIbáñez‐gonzález, R., Ibáñez‐gonzález, M.J., Ide, T., Ijaz, Muhammad Fazal, Impicciatore, R., Ingwersen, M., Ioannides, D., Iseppi, L., Islam, M.M., Jaakkola, M., Jagger, S., Jagosh, J., Jenkin, G., Joelsson, T., Johansen, R.E.B., Johnsen, H.C., Garmann Jona, G., Jones, T., Judit, O., Kalalahti, M., Kang, M., Kantamaneni, K., Kaplan, L., Kapsalis, V., Karbowski, A., Katsoni, V., Kavish, D.R., Kawamura, H., Keilman, N.W., Kelly, J., Kenneth, H., Kepaptsoglou, K., Kevin, D., Kewley, S., Kim, J.-C., Kim, K.-Y., Kim, S., Kimengsi, J.N., Klein, J., Kleine, M., Klemes, J.I.R.I., Klepp, S., Klinkenberg, L.E.F., Knight, L., Knowles, J., Koerner, S., Konsolakis, K., Konstantinov, V., Kopkin, N.K., Kordova, S., Kosinski, E., Kostelka, F., Kot, S., Kotter, R., Kramers, A., Krienert, J.L., Kubon, M., Kuffer, M., Kungolos, A., Kuttner, P., Kużelewska, E., Ladd, A.E., Lammi, M., Landrum, J., Lange, B., Languilaire, T.D., Lantz, J.-C., Laudal, B., Laurentsyeva, T., Lavizzari, N., Lavoie, A., Feuvre, J.L., Leakey, N., Lee, R., Lee, A., Lee, E., Lee, J., Lentner, J.-H., Lenz‐taguchi, C., Leong, H., Levac, W.S., Lewin, L., Lewinson, E., Li, T., Li, F., Li, G., Li, M., Liczmańska‐kopcewicz, Y., Lillard, K., Linková, C., Links, M., Lipinski, P., Storto, J.L., Lochtman, C., Lockwood, K., Loh, A., Lomonaco‐benzing, V., Łopaciuk‐gonczaryk, R., López, B., lópez, D., Lorenzini, J., Löther, A., Loughnan, C., Love, T., Lucas, M.L., Ubago, J., Lukić, J., Lumley‐sapanski, A., Macedo, I., Macfarlane, S., Machimbarrena, J.M., Magda, R., Magrane, D., Maier, D., Majić, S., Majumdar, S., Makarovič, M., Malekigorji, M., Mallick, B., Malone, D., Mandić, D., Maniou, T., Mannell, J.M., Barbutiu, S., Marczak, M., Markvica, K.M., Aragón, M.D.M., Martín, J.S.M., Pereira, A., Marzal‐felici, J., Mason, F., Mather, J., Matijosaitiene, I., MatthewsMattisson, R., Mattisson, C., Matuszak, Ł., Matuzeviciute, K., Mauerer, G., Mayer, A., McCaig, C., McClearn, D., McKee, S.C., McKendry, S., McMahon, M., McReynolds, P., Medina‐vicent, M., Medyna, G., Mees, H., Meil, G., Meringolo, P., Miciuła, I., Milczarek‐andrzejewska, D., Miles, P., Milivojević, S., Miller, G., Minello, A., Miron, D., Mironeasa, S., Misra, J., Mitchell, T., Moldovan, O., Molero, P.P., Møllersen, S., Momsen, J.H., Moniz, A.B., Morea, D., Moreau, M.-P., Morgan, D.L., Morgan, H., Moscatelli, S., Mostowska, M., Mousavi, A., Mousavi, S., Mrugalska, B., Muinos, G., Mukungu, K., Mukuni, J., Murakami, D., Muresan, I.C., Murib, Z., Muro, A., Mustafa, G., Nackerud, L., Nalmpantis, D., Napal, M., Närvi, J., Naser, M., Nash, V., Navarre‐jackson, L., Navarro, R., Nazarczuk, D., Neale, J., Necula, J., Němec, S., Neven, D., Nevgi, A., Newbold, A., Newton, G., New, A., Niakšu, O., Niiniluoto, I., Nkogo, J.C., Nobre, S., Nunn, P., Oakes, R., Obrad, C., Oke, A., Okorie, O., Oncioiu, I., Ormsbee, F., Ortega‐sánchez, D., Osgood, J., Osorio, C., Oswald, J., Otis, M.D., Ouassini, A., Oxford, S., Page, T., Paixão, M.J., De Pajares, E.M., Palmesr, E., Palos‐sánchez, P., Pamučar, Dragan, Pan, H., Panek, J., Pankowska, M., Papadakis, S., Papafilippou, V.P., Medina, R., Park, C.S., Partalidou, M., Passantino, A., Passini, S., Paul, S., Pavliuk, R., Pearce, P., Pease, K., Pentaris, P., Perez, V.W., Pérez‐armendáriz, C., Perez‐vaisvidovsky, N., Perez‐y‐perez, M., Perry, N., Prtchu, D., Peterson, D.A.M., Alexandru‐ionut, Petrykowski, Petrykowski, P., Phillips, L., Pickard, S., Pickel, A., Pieke, F., Piekut, A., Pierce, S., Pierrakis, Y., Piguet, E., Pleace, N., Połom, M., Polsa, P., Ponticorvo, M., Pookulangara, S., Pope, J., Popoli, P., Postigo, J.C., Price‐Wolf, J., Prior, S., Privitera, D., Prud’homme, C., Prosser, J., Prus, P., Puiu, S., Purcell, R., Pyrialakou, D., Quam‐wickham, N., Quarmby, T., Quinlan, K.M., Quinn, A., Quinn, R., Raciti, M., Radicić, D., Rahimi, B., Ramlo, S., Randle, H., Ratajczak, M., Raymond, T., Recio‐menéndez, M., Reese, L.A., Regner, T., Reichman, J., WReim, iebke, R., Pastor, A.M., Rexhepi, G., Reyes‐menendez, A., Reynaud, C., Ribeiro‐soriano, D., Ricci, S., Ridaura, G., Rita, C., Roberts, M., Roberts, G., Roberts, K., Rockerbie, D., Rodger, J.A., Rodin, G., Rodrigues, D.R., Martín, J.A., Rodríguez, C.F., Rodriguez‐modroño, P., Romero‐rodríguez, L.M., Rončáková, T., Roper, I., Rorie, M.R., Marzán, C.F., Rose, G., Rose, M., Rosen, R., Roth, R., Roubík, H., Roumpos, C., Rowbottom, D., Roy, J., Ruban, D., Rubira‐garcía, R., Ruiperez‐valiente, J.A., Ruiz, R., Ruiz‐real, J.L., Russell, B., Russo, K., Sabol, W., Safonte, F., Salin, M., Salom‐carrasco, J.S., Sánchez, L.D., Sanghera, Santos, B.S., Silva, D., Sanz, F., Sanz‐altamira, B., Sarapura, S., Sari, D., Satybaldieva, E., Saura, J.R., Sayed, N., Scandurra, C., Schartner, A., Schellekens, J., Schenk‐hoppé, K.R., Scherer, L., Schewe, J.A., Schewe, R., Schiller, N.G., Schmidt, E.-M., Schneickert, C., Schneider, J., Scott, H., Scott, P., Seibel, K., Seidler, R., Seifert, S.S., Puyuelo, M.S., Azevedo, P.S., Lopez, A.E.S., Raamkumar, A.S., Blundo, D., Severo, M., Shakya, K.M., Shapiro, A., Shaw, I.F., Shaw, T.V., Shea, B., Shearer, H., Sheldon, S., Shell‐duncan, B., Shepherd, S., Sheridan, L., Siemienska, R., Sillup, G.P., Simeon, J.C., Simonelli, A., Skilodimou, H.D., Škrinjarić, T., Slater, G., Smardon, R., Smith, J., Smoląg, K., Snauwaert, D.T., Soanes‐white, T., Sobocińska, M., Sohaib, O., Soldatić, K., Sorainen, G.T., Soldatos, A., Sørensen, N.N., Spanu, S., Stadlober, E., Stafford, F., Ștefănescu‐mihăilă, R.O., Stefanini, A., Štefko, R., Steglich, E., Steirer, G., Stephenson, M.O., Stoecker, R., Stoffelen, A., Strang, A., Suppa, D., Sutton, J., Svobodová, L., Swigon, M., Synnott, J., Sytsma, V., Tabe, T., Tajeddini, K., Tang, S., Taylor, B., Taylor, C., Teignier, M., Teixeira, C., Tempelaar, D., Ter Avest, K.H., Ter Horst, E., Testa, M.R., Thakur, N., Thiamwong, L., Thijsen, A., Thomas, B.A., Thompson, C., Thompson, D., Tisdall, K., Toft, Mancini, Torell, A., Toscano‐hernández, G., Tregua, A.E., Triandafyllidou, M., Tseloni, A., Seloni, A., Tsikouras, P., Tsogas, G., Twamley, K., Tyler, D.U., Haque, A., Underwood, M., Urbański, M., Uribe‐toril, J., Vaezipour, A., Van Hove, L.V., Huylenbroeck, G., Van Nuland, S., Vanner, C., Vázquez‐cano, E., Veen, E., Veintimilla, S.G.-A., Veković, M., Velija, P., Venco, E.M., Verticelli, A., Vicente, P.V., Estiarte, C., Višnjić, A., Visvizi, A., Vlasblom, J.D., Volsche, S.V., Fintel, D., Von Keyserlingk, L., Vranješević, J., Walter, K.V., Wandosell, G., Wang, Y., Wasileski, G., Wastl‐walter, D., Weaving, C., Weenik, D., Wehr, K., Wei, X., Wharton, A., White, G., Whitehouse, H., Whitley, C.T., Whitman, L., Wiersma‐mosley, J.D., Wilcke, H., Wilkes, R., Williams, L., Williamson, R.D., Wimalasena, L., Wiseman, A., Wołek, M., Wright, E.Q., Wroblewski, A., Wyile, A.S., Wynn, C., Xu, X., Xue, B., Yang, J., Yoe, T.M., Young, M., Younus, M., Yu, T.-F., Yuan, Q., Zadra, C., Zaharijević, A., Zajda, J., Zander, K., Zbuchea, A., Zelin, A., Zhang, C., Zippel, K., Zitricky, V., Živanović, P., Zou, L., Zufferey, C., Zuhdi, M., Zumeta, W.M., Abbas, A., Abel, G., Abreu, A., Adam, A., Adamek, M., Adiletta, G., Adusei-asante, K.A., Romeo, M.D.M., Alderson, A., Alfaro, E., Aliverti, A., Almeida, Fernando, Álvarez-gonzález, L.I., Amelina, A., Anand, C., Anderson, G., Andreasson, J., Ang, I., Aragon, J., Arcidiacono, C., Arcuri, S., Assante, D., Atukeren, E., Avery, H., Ayeb-karlsson, S., Azadi, H., Bachman, R., Bader, M., Badulescu, A., Bahmanteymouri, E., Baines, S., Baker, T., Baker‐beall, C., Bañón, L., Bar‐am, N., Barbier‐greenland, K., Barnett, R., Barragán‐escandón, A., Barreto, A.M., Barrett, E., Bartkowski, J., Bartram, R., Bartzas, G., Bates, D., Baviera‐puig, A., Bayley, A., Beazley, H., Beer, C., Behr, H., Beier, G., Belford, N., Bencivenga, R., Benli, A.E., Benton‐short, L., Berei, J.M., Berbel‐pineda, E., Bernstein, Berntzen, E.R., Bertella, L., Birney, G., Bittle, M., Black, S., Rivero, L.B., Blattner, J.J., Blok, C., Blount, A., Boas, Y., Bockarie, I., Bockerman, A., Bodén, P., Bönisch‐brednich, L., Bontje, B., Bontje, M., Borsellino, V., Bostan, I., Bowl, M., Bowman, B., Bracci, E., Bracken, C.M., Bradley, H., Brereton, P., Brewer, J., Bridge, D., Brooks, S., Brown, Andrijana, Brzoska, M., Brzozowski, W., Buckley, G., Buente, W., Bullaro, G.R., Burke, M.D., Burlacu, S., Busu, M., Butler, S., Byrne, J., Cabral, L., Cai, Y., Cajias, M., Calin, A.C., Callegari, C., Camarero, M., Campbell-figuerola, H., Campbell, J.R., Cannito, M., Canonico, E., Canosa, A., Carabelli, G., Carlbom, A., Carlone, T., Caron, R., Carpenter, A., Caruso, G., Casais, B., Castro, M.P., Cava, M.-J., Čeněk, J., Cerchione, R., Certomà, C., Chan, E., Charles, D., Charlwood, A., Chatzifotiou, S., Chell, K., Chen, L., Chen, Q., Chen, W.-J., Ching, L., Christensen, J., Ciasullo, M.V., Cimermanová, I., Činčera, J., Cipollina, M., Clutterbuck, R., Cochrane, B., Collin, K., Conley, R., Connell, H., Connelly, J., Connelly, L., Connelly, R., Conti, D., Conversi, D., Conway, G., Cooper, S., Cope, M., Corsini, F., Cristian, P., Crohn, H.M., Croog, R.C., Salazar, T., Csiszár, C., D’auria, I., D’souza, A., D’souza, N., Dabija, D.-C., Dagg, J., Dalby, S., DaleDalsgård, B., Dʹamato, A.L., Daniel, D., Dant, L., Dantas, C., Darwin, H., Dashper, K., David, M.E., De Flippo, D., De, A., Edi, M., Velázquez, E.D.C., Velázquez, F., Del Vecchio, P., Delatolla, A., Delgado, P., Delgado‐romero, E., Delrosso, J., Desimone, J., Detlefsen, L., Devaney, C., Díaz, L.M., Didham, R., Diogo, E., Dirakis, A., Doberneck, D., Doidge, M.D., Molero, G., Dombrowski, P.J., Doñate, C., Đorđević, Martín, Reis, P.G.R., Doucek, P., Dundes, L., Dvouletý, O., Dybo, T., Eastman, J., Eckhardt, J., Economou, A., Edler, D., Edu, U., Ekblom, P.E., Khaled, D., Ellis, C., Elsabry, E., Erceg, A., Erokhin, V., Ertz, M., Everitt, J., Evers, A., Falcone, P.M.F., Cabana, P., Fawcett, B., Fearnley, B., Featherstone, M., Ferreira, M., Ferreira, P., Fetner, T., Fisher, J., Fisher, R., Fitzpatrick, T., Flanagan, C., Fogarty, E.A., Fonchingong, C.C., Fontana, M., Fook, J., Foreman, A.M., Foster‐mcgregor, N., Fox, S., Franco, J.A., Franklin, A.L., Friedrich, T., Fromm, I., Fu, N., Fucà, R., Fukuda, Y., Fusco, G., Gabriela, D., Galan, D., Gamo, A., Galiano, J., Garcia, A., García, M.E.A., García‐germán, S., García‐machado, J.J., García‐ruiz, C.R., Gavini, M., Gazzano, A., Gebhardt, M., Gerson, S., Gherghina, Ş.C., Gibbs, P., Gilhooly, D., Gill, F., Gill, N., Gil‐lopez, A.J., Ginès Fabrellas, A., Giuffrida, N., Giuliani, G., Goddard, J., Godderis, R., Goh, C.S., Gomes, O., Goncharuk, A.G., Canche, M.G., Pérez, I.G., Valero, G., González, R.C.L., Gonzalez‐benson, O., Gonzalez‐feliu, J., González‐lópez, M., Gozdziak, E., Granx, B., Gran, R., Gray, S.L., Grbes, A., Grondys, K., Grugan, S., Guenther, J., Guijarro, F., Gurko, T., Haas, L.L., Hagellx, A., Hagell, H., Hallgrímsdóttir, H., Hamada, T., Hanf, J., Hannouf, M., Hao, F., Harman, G., Harris, K.L., Harris, R., Harrison, N.H., Healy, G., Healy, K., Heikkilä, E., Hellmich, C., Henig, J., Henninger, C.E., Heo, W., Herman, C., Herrero‐diz, P., Heyman, J., Hibbert, N., Hillman, A.L., Hillman, B., Hine, B., Hino, K., Hinten, M., Hipp, L., Hoang, D., Holleran, D., Hollin, I., Holm, M., Holmes, C., Hook, G., Hoornweg, D., Hopper, L., Hossain, M., Hoxhaj, R., Hu, B., Huang, Y., Huarita, E., Hudec, O., Humbert, A.L., Hung, M.-C., Hunt, A., Husu, L., IanoleIbáñez‐gonzález, R., Ibáñez‐gonzález, M.J., Ide, T., Ijaz, Muhammad Fazal, Impicciatore, R., Ingwersen, M., Ioannides, D., Iseppi, L., Islam, M.M., Jaakkola, M., Jagger, S., Jagosh, J., Jenkin, G., Joelsson, T., Johansen, R.E.B., Johnsen, H.C., Garmann Jona, G., Jones, T., Judit, O., Kalalahti, M., Kang, M., Kantamaneni, K., Kaplan, L., Kapsalis, V., Karbowski, A., Katsoni, V., Kavish, D.R., Kawamura, H., Keilman, N.W., Kelly, J., Kenneth, H., Kepaptsoglou, K., Kevin, D., Kewley, S., Kim, J.-C., Kim, K.-Y., Kim, S., Kimengsi, J.N., Klein, J., Kleine, M., Klemes, J.I.R.I., Klepp, S., Klinkenberg, L.E.F., Knight, L., Knowles, J., Koerner, S., Konsolakis, K., Konstantinov, V., Kopkin, N.K., Kordova, S., Kosinski, E., Kostelka, F., Kot, S., Kotter, R., Kramers, A., Krienert, J.L., Kubon, M., Kuffer, M., Kungolos, A., Kuttner, P., Kużelewska, E., Ladd, A.E., Lammi, M., Landrum, J., Lange, B., Languilaire, T.D., Lantz, J.-C., Laudal, B., Laurentsyeva, T., Lavizzari, N., Lavoie, A., Feuvre, J.L., Leakey, N., Lee, R., Lee, A., Lee, E., Lee, J., Lentner, J.-H., Lenz‐taguchi, C., Leong, H., Levac, W.S., Lewin, L., Lewinson, E., Li, T., Li, F., Li, G., Li, M., Liczmańska‐kopcewicz, Y., Lillard, K., Linková, C., Links, M., Lipinski, P., Storto, J.L., Lochtman, C., Lockwood, K., Loh, A., Lomonaco‐benzing, V., Łopaciuk‐gonczaryk, R., López, B., lópez, D., Lorenzini, J., Löther, A., Loughnan, C., Love, T., Lucas, M.L., Ubago, J., Lukić, J., Lumley‐sapanski, A., Macedo, I., Macfarlane, S., Machimbarrena, J.M., Magda, R., Magrane, D., Maier, D., Majić, S., Majumdar, S., Makarovič, M., Malekigorji, M., Mallick, B., Malone, D., Mandić, D., Maniou, T., Mannell, J.M., Barbutiu, S., Marczak, M., Markvica, K.M., Aragón, M.D.M., Martín, J.S.M., Pereira, A., Marzal‐felici, J., Mason, F., Mather, J., Matijosaitiene, I., MatthewsMattisson, R., Mattisson, C., Matuszak, Ł., Matuzeviciute, K., Mauerer, G., Mayer, A., McCaig, C., McClearn, D., McKee, S.C., McKendry, S., McMahon, M., McReynolds, P., Medina‐vicent, M., Medyna, G., Mees, H., Meil, G., Meringolo, P., Miciuła, I., Milczarek‐andrzejewska, D., Miles, P., Milivojević, S., Miller, G., Minello, A., Miron, D., Mironeasa, S., Misra, J., Mitchell, T., Moldovan, O., Molero, P.P., Møllersen, S., Momsen, J.H., Moniz, A.B., Morea, D., Moreau, M.-P., Morgan, D.L., Morgan, H., Moscatelli, S., Mostowska, M., Mousavi, A., Mousavi, S., Mrugalska, B., Muinos, G., Mukungu, K., Mukuni, J., Murakami, D., Muresan, I.C., Murib, Z., Muro, A., Mustafa, G., Nackerud, L., Nalmpantis, D., Napal, M., Närvi, J., Naser, M., Nash, V., Navarre‐jackson, L., Navarro, R., Nazarczuk, D., Neale, J., Necula, J., Němec, S., Neven, D., Nevgi, A., Newbold, A., Newton, G., New, A., Niakšu, O., Niiniluoto, I., Nkogo, J.C., Nobre, S., Nunn, P., Oakes, R., Obrad, C., Oke, A., Okorie, O., Oncioiu, I., Ormsbee, F., Ortega‐sánchez, D., Osgood, J., Osorio, C., Oswald, J., Otis, M.D., Ouassini, A., Oxford, S., Page, T., Paixão, M.J., De Pajares, E.M., Palmesr, E., Palos‐sánchez, P., Pamučar, Dragan, Pan, H., Panek, J., Pankowska, M., Papadakis, S., Papafilippou, V.P., Medina, R., Park, C.S., Partalidou, M., Passantino, A., Passini, S., Paul, S., Pavliuk, R., Pearce, P., Pease, K., Pentaris, P., Perez, V.W., Pérez‐armendáriz, C., Perez‐vaisvidovsky, N., Perez‐y‐perez, M., Perry, N., Prtchu, D., Peterson, D.A.M., Alexandru‐ionut, Petrykowski, Petrykowski, P., Phillips, L., Pickard, S., Pickel, A., Pieke, F., Piekut, A., Pierce, S., Pierrakis, Y., Piguet, E., Pleace, N., Połom, M., Polsa, P., Ponticorvo, M., Pookulangara, S., Pope, J., Popoli, P., Postigo, J.C., Price‐Wolf, J., Prior, S., Privitera, D., Prud’homme, C., Prosser, J., Prus, P., Puiu, S., Purcell, R., Pyrialakou, D., Quam‐wickham, N., Quarmby, T., Quinlan, K.M., Quinn, A., Quinn, R., Raciti, M., Radicić, D., Rahimi, B., Ramlo, S., Randle, H., Ratajczak, M., Raymond, T., Recio‐menéndez, M., Reese, L.A., Regner, T., Reichman, J., WReim, iebke, R., Pastor, A.M., Rexhepi, G., Reyes‐menendez, A., Reynaud, C., Ribeiro‐soriano, D., Ricci, S., Ridaura, G., Rita, C., Roberts, M., Roberts, G., Roberts, K., Rockerbie, D., Rodger, J.A., Rodin, G., Rodrigues, D.R., Martín, J.A., Rodríguez, C.F., Rodriguez‐modroño, P., Romero‐rodríguez, L.M., Rončáková, T., Roper, I., Rorie, M.R., Marzán, C.F., Rose, G., Rose, M., Rosen, R., Roth, R., Roubík, H., Roumpos, C., Rowbottom, D., Roy, J., Ruban, D., Rubira‐garcía, R., Ruiperez‐valiente, J.A., Ruiz, R., Ruiz‐real, J.L., Russell, B., Russo, K., Sabol, W., Safonte, F., Salin, M., Salom‐carrasco, J.S., Sánchez, L.D., Sanghera, Santos, B.S., Silva, D., Sanz, F., Sanz‐altamira, B., Sarapura, S., Sari, D., Satybaldieva, E., Saura, J.R., Sayed, N., Scandurra, C., Schartner, A., Schellekens, J., Schenk‐hoppé, K.R., Scherer, L., Schewe, J.A., Schewe, R., Schiller, N.G., Schmidt, E.-M., Schneickert, C., Schneider, J., Scott, H., Scott, P., Seibel, K., Seidler, R., Seifert, S.S., Puyuelo, M.S., Azevedo, P.S., Lopez, A.E.S., Raamkumar, A.S., Blundo, D., Severo, M., Shakya, K.M., Shapiro, A., Shaw, I.F., Shaw, T.V., Shea, B., Shearer, H., Sheldon, S., Shell‐duncan, B., Shepherd, S., Sheridan, L., Siemienska, R., Sillup, G.P., Simeon, J.C., Simonelli, A., Skilodimou, H.D., Škrinjarić, T., Slater, G., Smardon, R., Smith, J., Smoląg, K., Snauwaert, D.T., Soanes‐white, T., Sobocińska, M., Sohaib, O., Soldatić, K., Sorainen, G.T., Soldatos, A., Sørensen, N.N., Spanu, S., Stadlober, E., Stafford, F., Ștefănescu‐mihăilă, R.O., Stefanini, A., Štefko, R., Steglich, E., Steirer, G., Stephenson, M.O., Stoecker, R., Stoffelen, A., Strang, A., Suppa, D., Sutton, J., Svobodová, L., Swigon, M., Synnott, J., Sytsma, V., Tabe, T., Tajeddini, K., Tang, S., Taylor, B., Taylor, C., Teignier, M., Teixeira, C., Tempelaar, D., Ter Avest, K.H., Ter Horst, E., Testa, M.R., Thakur, N., Thiamwong, L., Thijsen, A., Thomas, B.A., Thompson, C., Thompson, D., Tisdall, K., Toft, Mancini, Torell, A., Toscano‐hernández, G., Tregua, A.E., Triandafyllidou, M., Tseloni, A., Seloni, A., Tsikouras, P., Tsogas, G., Twamley, K., Tyler, D.U., Haque, A., Underwood, M., Urbański, M., Uribe‐toril, J., Vaezipour, A., Van Hove, L.V., Huylenbroeck, G., Van Nuland, S., Vanner, C., Vázquez‐cano, E., Veen, E., Veintimilla, S.G.-A., Veković, M., Velija, P., Venco, E.M., Verticelli, A., Vicente, P.V., Estiarte, C., Višnjić, A., Visvizi, A., Vlasblom, J.D., Volsche, S.V., Fintel, D., Von Keyserlingk, L., Vranješević, J., Walter, K.V., Wandosell, G., Wang, Y., Wasileski, G., Wastl‐walter, D., Weaving, C., Weenik, D., Wehr, K., Wei, X., Wharton, A., White, G., Whitehouse, H., Whitley, C.T., Whitman, L., Wiersma‐mosley, J.D., Wilcke, H., Wilkes, R., Williams, L., Williamson, R.D., Wimalasena, L., Wiseman, A., Wołek, M., Wright, E.Q., Wroblewski, A., Wyile, A.S., Wynn, C., Xu, X., Xue, B., Yang, J., Yoe, T.M., Young, M., Younus, M., Yu, T.-F., Yuan, Q., Zadra, C., Zaharijević, A., Zajda, J., Zander, K., Zbuchea, A., Zelin, A., Zhang, C., Zippel, K., Zitricky, V., Živanović, P., Zou, L., Zufferey, C., Zuhdi, M., and Zumeta, W.M.

Published
2020

47. Search for Magnetic Monopoles with the MoEDAL Forward Trapping Detector in 13 TeV Proton-Proton Collisions at the LHC

Author

Acharya, B, Alexandre, J, Baines, S, Benes, P, Bergmann, B, Bernabéu, J, Branzas, H, Campbell, M, Caramete, L, Cecchini, S, De Montigny, M, De Roeck, A, Ellis, J, Fairbairn, M, Felea, D, Flores, J, Frank, M, Frekers, D, Garcia, C, Hirt, A, Janecek, J, Kalliokoski, M, Katre, A, Kim, D, Kinoshita, K, Korzenev, A, Lacarrère, D, Lee, S, Leroy, C, Lionti, A, Mamuzic, J, Margiotta, A, Mauri, N, Mavromatos, N, Mermod, P, Mitsou, V, Orava, R, Parker, B, Pasqualini, L, Patrizii, L, Pǎvǎlaş, G, Pinfold, J, Popa, V, Pozzato, M, Pospisil, S, Rajantie, A, Ruiz De Austri, R, Sahnoun, Z, Sakellariadou, M, Sarkar, S, Semenoff, G, Shaa, A, Sirri, G, Sliwa, K, Soluk, R, Spurio, M, Srivastava, Y, Suk, M, Swain, J, Tenti, M, Togo, V, Tuszyński, J, Vento, V, Vives, O, Vykydal, Z, Whyntie, T, Widom, A, Willems, G, Yoon, J, Zgura, I, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., De Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Flores, J., Frank, M., Frekers, D., Garcia, C., Hirt, A. M., Janecek, J., Kalliokoski, M., Katre, A., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Parker, B., Pasqualini, L., Patrizii, L., Pǎvǎlaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., Ruiz De Austri, R., Sahnoun, Z., Sakellariadou, M., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Whyntie, T., Widom, A., Willems, G., Yoon, J. H., Zgura, I. S., Acharya, B, Alexandre, J, Baines, S, Benes, P, Bergmann, B, Bernabéu, J, Branzas, H, Campbell, M, Caramete, L, Cecchini, S, De Montigny, M, De Roeck, A, Ellis, J, Fairbairn, M, Felea, D, Flores, J, Frank, M, Frekers, D, Garcia, C, Hirt, A, Janecek, J, Kalliokoski, M, Katre, A, Kim, D, Kinoshita, K, Korzenev, A, Lacarrère, D, Lee, S, Leroy, C, Lionti, A, Mamuzic, J, Margiotta, A, Mauri, N, Mavromatos, N, Mermod, P, Mitsou, V, Orava, R, Parker, B, Pasqualini, L, Patrizii, L, Pǎvǎlaş, G, Pinfold, J, Popa, V, Pozzato, M, Pospisil, S, Rajantie, A, Ruiz De Austri, R, Sahnoun, Z, Sakellariadou, M, Sarkar, S, Semenoff, G, Shaa, A, Sirri, G, Sliwa, K, Soluk, R, Spurio, M, Srivastava, Y, Suk, M, Swain, J, Tenti, M, Togo, V, Tuszyński, J, Vento, V, Vives, O, Vykydal, Z, Whyntie, T, Widom, A, Willems, G, Yoon, J, Zgura, I, Acharya, B., Alexandre, J., Baines, S., Benes, P., Bergmann, B., Bernabéu, J., Branzas, H., Campbell, M., Caramete, L., Cecchini, S., De Montigny, M., De Roeck, A., Ellis, J. R., Fairbairn, M., Felea, D., Flores, J., Frank, M., Frekers, D., Garcia, C., Hirt, A. M., Janecek, J., Kalliokoski, M., Katre, A., Kim, D. -W., Kinoshita, K., Korzenev, A., Lacarrère, D. H., Lee, S. C., Leroy, C., Lionti, A., Mamuzic, J., Margiotta, A., Mauri, N., Mavromatos, N. E., Mermod, P., Mitsou, V. A., Orava, R., Parker, B., Pasqualini, L., Patrizii, L., Pǎvǎlaş, G. E., Pinfold, J. L., Popa, V., Pozzato, M., Pospisil, S., Rajantie, A., Ruiz De Austri, R., Sahnoun, Z., Sakellariadou, M., Sarkar, S., Semenoff, G., Shaa, A., Sirri, G., Sliwa, K., Soluk, R., Spurio, M., Srivastava, Y. N., Suk, M., Swain, J., Tenti, M., Togo, V., Tuszyński, J. A., Vento, V., Vives, O., Vykydal, Z., Whyntie, T., Widom, A., Willems, G., Yoon, J. H., and Zgura, I. S.

Abstract

MoEDAL is designed to identify new physics in the form of long-lived highly ionizing particles produced in high-energy LHC collisions. Its arrays of plastic nuclear-track detectors and aluminium trapping volumes provide two independent passive detection techniques. We present here the results of a first search for magnetic monopole production in 13 TeV proton-proton collisions using the trapping technique, extending a previous publication with 8 TeV data during LHC Run 1. A total of 222 kg of MoEDAL trapping detector samples was exposed in the forward region and analyzed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges exceeding half the Dirac charge are excluded in all samples and limits are placed for the first time on the production of magnetic monopoles in 13 TeV pp collisions. The search probes mass ranges previously inaccessible to collider experiments for up to five times the Dirac charge.

Published
2017

48. Outcome of caudal superficial epigastric axial pattern flaps in dogs and cats: 70 cases (2007‐2020).

Author

Forster, K., Cutando, L. S., Ladlow, J., Anderson, D., Burton, C., Das, S., Gibson, S., Kulendra, N., Emmerson, T., Baines, S., Rutherford, L., Paulino, R. D., Fontanini, R., Compagnone, K., and De La Puerta, B.

Subjects
DOGS, SURGICAL margin, WOUND healing, WOUND infections, ANTIBIOTIC prophylaxis, MEDICAL records
Abstract

Objectives: To describe the outcome and complications associated with the use of caudal superficial epigastric axial pattern flaps in dogs and cats. Material and Methods: Multicentre retrospective review and descriptive study of clinical records of dogs and cats having undergone caudal superficial epigastric axial pattern flaps between 2007 and 2020. Data retrieved included signalment, aetiology of surgical defect, tumour type, presence/absence of clean surgical margins, presence/absence of post‐operative wound infection, use of peri‐ and post‐operative antibiotics, duration of anaesthesia, duration of surgery, presence and duration of hypothermia, presence and duration of hypotension, presence/absence of post‐operative surgical drain and length of caudal superficial epigastric axial pattern flap. The incidence of complications and outcomes were documented. Results: Seventy cases met the inclusion criteria; 51 dogs and 19 cats. In dogs, 67% of cases developed complications (59% minor, 8% major) and 33% had uneventful wound healing. In cats, 53% of cases developed complications, (47% minor, 5% major) and 47% had uneventful wound healing. In dogs, the percentage of cases experiencing dehiscence, necrosis, seroma, oedema and post‐operative infection was 31%, 29%, 26%, 26% and 16% respectively. In cats, this was 26%, 16%, 11%, 0% and 5% respectively. A good overall outcome was seen in 77% of dogs and 79% of cats. A poor overall outcome was seen in 4% of dogs and 0% of cats. Clinical Significance: Caudal superficial epigastric axial pattern flaps are traditionally thought more robust than other flaps, yet complication rates remain high, despite a high overall success rate. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Outcome of superficial brachial axial pattern flaps used to close skin defects in dogs: 16 cases (1996‐2019).

Author

Villedieu, E., Nolff, M. C., Del Magno, S., Emmerson, T., Field, E., Hattersley, R., De La Puerta, B., Ragni, R. A., and Baines, S. J.

Subjects
DOGS, REOPERATION, FREE flaps, SURGICAL complications, BIOMEDICAL materials, WOUND healing, CHRONIC wounds & injuries, DOG bites
Abstract

Objectives: To report the complication rate, type of complications and outcome of the superficial brachial axial pattern flap when used for closure of skin defects in dogs. Materials and Methods: Medical records of dogs treated with a superficial brachial axial pattern flap for closure of a skin defect were reviewed. Information regarding signalment, reason for axial pattern flap use, skin flap size, flap healing, postoperative complications and need for revision surgery was collected. Results: Sixteen dogs were included in the study. Indications for the superficial brachial axial pattern flap included closure following tumour removal (15/16, 94%) and management of a non‐healing wound on the olecranon (1/16, 6%). Postoperative complications occurred in all dogs and included partial dehiscence (7/16, 44%), partial flap necrosis (6/16. 38%), seroma formation (5/16, 31%), flap oedema (3/16, 19%) and complete flap necrosis (2/16, 13%). Eight flaps (50%) healed without open wound management or additional surgery. Five dogs required open wound management without additional surgery, and three dogs (19%) required revision surgery. Clinical Significance: Use of the superficial brachial axial pattern flap was associated with a high rate of complications. Most complications were managed without additional surgery and all wounds eventually healed, in some cases after prolonged open wound management. [ABSTRACT FROM AUTHOR]

Published
2022
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