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1. Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest – A propensity-matched control study (Isocare)

Author: Teiten, Christelle, Bailly, Pierre, Tonnelier, Jean-Marie, Bodenes, Laetitia, de Longeaux, Kahaia, and L’Her, Erwan
Published: 2024
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2. PROACTIVE SCREENING ALGORITHM FOR EARLY-ONSET PNEUMONIA IN PATIENTS WITH OUT-OF-HOSPITAL CARDIAC ARREST: A BEFORE-AFTER IMPLEMENTATION STUDY

Author: Lemée, Pauline, Chapalain, Xavier, Bailly, Pierre, Sparrow, Rosemary L., Jean-Michel, Vanessa, Prat, Gwenael, Renault, Anne, Tonnelier, Jean-Marie, and Aubron, Cécile
Published: 2024
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3. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study

Author: Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J., Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, and Timsit, Jean-François
Published: 2023
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4. Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)

Author: Huang, Stephen, Vignon, Philippe, Mekontso-Dessap, Armand, Tran, Ségolène, Prat, Gwenael, Chew, Michelle, Balik, Martin, Sanfilippo, Filippo, Banauch, Gisele, Clau-Terre, Fernando, Morelli, Andrea, De Backer, Daniel, Cholley, Bernard, Slama, Michel, Charron, Cyril, Goudelin, Marine, Bagate, Francois, Bailly, Pierre, Blixt, Patrick-Johansson, Masi, Paul, Evrard, Bruno, Orde, Sam, Mayo, Paul, McLean, Anthony S., and Vieillard-Baron, Antoine
Published: 2022
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5. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Author: Li, Jie, Mirza, Sara, Vines, David, Elshafei, Ahmad A, Scott, Brady J, Weiss, Tyler, Kaur, Ramandeep, Harnois, Lauren J, Miller, Amanda, Cerda, Flor, Klein, Andrew, Burd, Jacob R, Posa-Kearney, Kathleen, Trump, Matthew, Jackson, Julie, Oetting, Trevor, Greenwood, Mark, Hazel, Lindsay, Kingery, Lisa, Mogri, Idrees, Morris, Lindsey, Moon, Joon Yong, Garnett, Julianne, Jia, Shijing, Nelson, Kristine, McNicholas, Bairbre, Cosgrave, David, Giacomini, Camilla, Laffey, John, Brennan, Aoife, Judge, Conor, Kernan, Maeve, Kelly, Claire, Ranjan, Ritika, Casey, Siobhan, O'Connell, Kevin, Newell, Evelyn, Gallagher, David, Nichol, Alistair, Curley, Ger, Estrada, Miguel Ibarra, García-Salcido, Roxana, Vargas-Obieta, Alexandra, Aguirre-Avalos, Guadalupe, Aguirre-Díaz, Sara A, Alcántar-Vallín, Luz, Alvarado-Padilla, Montserrat, Chávez-Peña, Quetzalcóatl, López-Pulgarín, José A, Mijangos-Méndez, Julio C, Marín-Rosales, Miguel, García-Alvarado, Jorge E, Baltazar-González, Oscar G, González-Guerrero, Maura C, Gutiérrez Ramírez, Paola G, Pavlov, Ivan, Gilman, Sean, Plamondon, Patrice, Roy, Rachel, Jayaraman, Dev, Shahin, Jason, Ragoshai, Raham, Kaur, Aasmine, Campisi, Josie, Dahine, Joseph, Perron, Stefanie, Achouri, Slimane, Racette, Ronald, Kulenkamp, Anne, Roca, Oriol, Pacheco, Andrés, García-de-Acilu, Marina, Masclans, Joan R, Dot, Irene, Perez, Yonatan, Bodet-Contentin, Laetitia, Garot, Denis, Ehrmann, Stephan, Mercier, Emmanuelle, Salmon Gandonnière, Charlotte, Morisseau, Marlène, Jouan, Youenn, Darwiche, Walid, Legras, Annick, Guillon, Antoine, Tavernier, Elsa, Dequin, Pierre-François, Tellier, Anne-Charlotte, Reignier, Jean, Lascarrou, Jean-Baptiste, Seguin, Amélie, Desmedt, Luc, Canet, Emmanuel, Guitton, Christophe, Marnai, Rémy, Callahan, Jean-Christophe, Landais, Mickaël, Chudeau, Nicolas, Darreau, Cédric, Tirot, Patrice, Saint Martin, Marjorie, Le Moal, Charlene, Nay, Mai-Anh, Muller, Grégoire, Jacquier, Sophie, Prat, Gwenaël, Bailly, Pierre, Ferrière, Nicola, Thille, Arnaud W, Frat, Jean-Pierre, Dellamonica, Jean, Saccheri, Clément, Buscot, Matthieu, Plantefève, Gaëtan, Contou, Damien, Roux, Damien, Ricard, Jean-Damien, Federici, Laura, Zucman, Noémie, Freita Ramos, Santiago, Amouretti, Marc, Besset, Sébastien, Gernez, Coralie, Delbove, Agathe, Voiriot, Guillaume, Elabbadi, Alexandre, Fartoukh, Muriel, Nseir, Saad, Préau, Sébastien, Favory, Raphaël, Pierre, Alexandre, Sement, Arnaud, Terzi, Nicolas, Sigaud, Florian, Candille, Clara, Turbil, Emanuele, Maizel, Julien, Brault, Clément, Zerbib, Yoan, Joret, Aurélie, Daubin, Cédric, Lefebvre, Laurent, Giraud, Alais, Auvet, Adrien, Vinsonneau, Christophe, Marzouk, Mehdi, Quenot, Jean-Pierre, Andreu, Pascal, Labruyère, Marie, Roudaut, Jean-Baptiste, Aptel, François, Boyer, Alexandre, Boyer, Philippe, Lacherade, Jean-Claude, Hille, Hugo, Bouteloup, Marie, Jeannot, Matthieu, Feller, Marc, Grillet, Guillaume, Levy, Bruno, Kimmoun, Antoine, Ibarra-Estrada, Miguel, Garcia-Salcido, Roxana, Trump, Matthew W, and Laffey, John G
Published: 2021
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6. Pressure-Support Ventilation vs T-Piece During Spontaneous Breathing Trials Before Extubation Among Patients at High Risk of Extubation Failure: A Post-Hoc Analysis of a Clinical Trial

Author: Boissier, Florence, Chatellier, Delphine, Deletage, Céline, Guignon, Carole, Joly, Florent, Olivry, Morgane, Veinstein, Anne, Benzekri-Lefevre, Dalila, Boulain, Thierry, Muller, Grégoire, Le Tulzo, Yves, Tadié, Jean-Marc, Maamar, Adel, Demiri, Suela, Mayaux, Julien, Decavèle, Maxens, Bouadma, Lila, Dupuis, Claire, Asfar, Pierre, Pierrot, Marc, Béduneau, Gaëtan, Boyer, Déborah, Delmas, Benjamin, Puech, Bérénice, Bachoumas, Konstantinos, Soum, Edouard, Cabasson, Séverin, Hoppe, Marie-Anne, Nseir, Saad, Pouly, Olivier, Bourdin, Gaël, Rosselli, Sylvène, Le Meur, Anthony, Garret, Charlotte, Martin, Maelle, Berquier, Guillaume, Thiagarajah, Abirami, Carteaux, Guillaume, Mekontso-Dessap, Armand, Poidevin, Antoine, Dureau, Anne-Florence, Azais, Marie-Ange, Colin, Gwenhaël, Mercier, Emmanuelle, Morisseau, Marlène, Sabatier, Caroline, Picard, Walter, Gainnier, Marc, Nguyen, Thi-My-Hue, Prat, Gwenaël, Schwebel, Carole, Buscot, Matthieu, Thille, Arnaud W., Coudroy, Rémi, Nay, Mai-Anh, Gacouin, Arnaud, Demoule, Alexandre, Sonneville, Romain, Beloncle, François, Girault, Christophe, Dangers, Laurence, Lautrette, Alexandre, Levrat, Quentin, Rouzé, Anahita, Vivier, Emmanuel, Lascarrou, Jean-Baptiste, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Massri, Alexandre, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Robert, René, Ragot, Stéphanie, and Frat, Jean-Pierre
Published: 2020
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7. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial

Author: Chatellier, Delphine, Boissier, Florence, Veinstein, Anne, Robert, René, Deletage-Métreau, Céline, Olivry, Morgane, Dahyot-Fizelier, Claire, Dargent, Auguste, Large, Audrey, Begot, Emmanuelle, Mancia, Claire, Decavele, Maxence, Dres, Martin, Lehingue, Samuel, Papazian, Laurent, Paul, Marine, Marin, Nathalie, Le Meur, Matthieu, Laissy, Mohammed, Rouzé, Anaita, Nseir, Saad, Henry-Lagarrigue, Matthieu, Yehia, Aihem, Martino, Frédéric, Cerf, Charles, Bailly, Pierre, Helms, Julie, Putegnat, Jean Baptiste, Mekontso-Dessap, Armand, Boulain, Thierry, Asfar, Pierre, Cabasson, Séverin, Wallet, Florent, Klouche, Kada, Bellec, Frédéric, Frat, Jean-Pierre, Ricard, Jean-Damien, Quenot, Jean-Pierre, Pichon, Nicolas, Demoule, Alexandre, Forel, Jean-Marie, Mira, Jean-Paul, Coudroy, Rémi, Berquier, Guillaume, Voisin, Benoit, Colin, Gwenhaël, Pons, Bertrand, Danin, Pierre Eric, Devaquet, Jérome, Prat, Gwenael, Clere-Jehl, Raphaël, Petitpas, Franck, Vivier, Emmanuel, Razazi, Keyvan, Nay, Mai-Anh, Souday, Vincent, Dellamonica, Jean, Argaud, Laurent, Ehrmann, Stephan, Gibelin, Aude, Girault, Christophe, Andreu, Pascal, Vignon, Philippe, Dangers, Laurence, Ragot, Stéphanie, and Thille, Arnaud W
Published: 2019
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8. Should we add patients in concordance of judgment learning tool panels? - An analysis between patients and primary care physicians.

Author: Lorenzo, Mathieu, Bailly, Pierre, and Lépine, Camille
Subjects: *PROFESSIONALISM, *SCALE analysis (Psychology), *PATIENTS' families, *MEDICAL personnel, *MEDICAL education, *PILOT projects, *LOGISTIC regression analysis, *COMPASSION, *STATISTICAL sampling, *PHYSICIANS' attitudes, *DESCRIPTIVE statistics, *LONGITUDINAL method, *THEMATIC analysis, *ODDS ratio, *ETHICS, *TRUST, *ROLE models, *INFERENTIAL statistics, *JUDGMENT (Psychology), *COMPARATIVE studies, *CASE studies, *DATA analysis software, *COMMITMENT (Psychology), *CONFIDENCE intervals, *ALTERNATIVE education, *PATIENTS' attitudes
Abstract: The Concordance of Judgment Learning Tool (CJLT) has been developed for distance asynchronous learning of professionalism in health sciences education. The learning of professionalism is induced by a student's comparison of their own responses with those of the panel members. Whilst CJLT programs typically include same profession experts in their panels, we believe that they could also include patients. Accordingly, we conducted a study aimed at comparing CJLT response patterns between two groups of primary care physicians (PCPs) and patients. We conducted a mixed prospective study of responses to a CJLT program based on a group of PCPs and a group of patients: an analysis of the response patterns of the two groups and a qualitative analysis of justifications. A total of 110 participants were included in the study: 70 patients and 40 PCPs. We found a significant difference in response patterns between the PCP and patient groups for nine of the fifteen questions (60%). The qualitative analysis of justifications between groups allowed us to comprehend patients' views on the professionalism of PCPs. Including patients in CJLT panels can enrich the feedback offered to students in these online training programs. [ABSTRACT FROM AUTHOR]
Published: 2024
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9. Outcomes in COVID-19 Patients With Acute Encephalopathy and Coma: An International Prospective Study

Author: Legriel, Stephane, primary, Badenes, Rafael, additional, Engrand, Nicolas, additional, Mendoza-Trujillo, Rocio, additional, Soulier, Pauline, additional, BENGHANEM, Sarah, additional, Pizzi, Michael, additional, Maciel, Carolina, additional, Chelly, Jonathan, additional, Zuber, Benjamin, additional, Labruyere, Marie, additional, Plantefeve, Gaetan, additional, Jacq, Gwenaëlle, additional, Galbois, Arnaud, additional, Launey, Yoann, additional, Argaud, Laurent, additional, lesieur, Olivier, additional, FERRE, Alexis, additional, paul, Marine, additional, guillon, Antoine, additional, Bailly, Pierre, additional, Beuret, Pascal, additional, de-Carne, Marie-Charlotte, additional, SIAMI, Shidasp, additional, Benzekri, Dalila, additional, Colin, Gwenhael, additional, Gaviria, Leidy, additional, Aldana, Jose Luis, additional, Bruel, Cedric, additional, Stoclin, Annabelle, additional, Sedillot, Nicholas, additional, Geri, Guillaume, additional, Samano, Daniel, additional, Sobczak, Evie, additional, Swafford, Emily, additional, O'Phelan, Kristine, additional, Meffert, Arnaud, additional, Holleville, Mathilde, additional, Silva, Stein, additional, Alves da Costa, Manoel José, additional, Mejia, Jorge, additional, and Alkhachroum, Ayham, additional
Published: 2023
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10. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study

Author: Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, Timsit, Jean-François, Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, and Timsit, Jean-François
Abstract: Purpose: We aimed to characterize the outcomes of patients with severe meningoencephalitis requiring intensive care. Methods: We conducted a prospective multicenter international cohort study (2017–2020) in 68 centers across 7 countries. Eligible patients were adults admitted to the intensive care unit (ICU) with meningoencephalitis, defined by an acute onset of encephalopathy (Glasgow coma scale (GCS) score ≤ 13), a cerebrospinal fluid pleocytosis ≥ 5 cells/mm3, and at least two of the following criteria: fever, seizures, focal neurological deficit, abnormal neuroimaging, and/or electroencephalogram. The primary endpoint was poor functional outcome at 3 months, defined by a score of three to six on the modified Rankin scale. Multivariable analyses stratified on centers investigated ICU admission variables associated with the primary endpoint. Results: Among 599 patients enrolled, 589 (98.3%) completed the 3-month follow-up and were included. Overall, 591 etiologies were identified in those patients which were categorized into five groups: acute bacterial meningitis (n = 247, 41.9%); infectious encephalitis of viral, subacute bacterial, or fungal/parasitic origin (n = 140, 23.7%); autoimmune encephalitis (n = 38, 6.4%); neoplastic/toxic encephalitis (n = 11, 1.9%); and encephalitis of unknown origin (n = 155, 26.2%). Overall, 298 patients (50.5%, 95% CI 46.6–54.6%) had a poor functional outcome, including 152 deaths (25.8%). Variables independently associated with a poor functional outcome were age > 60 years (OR 1.75, 95% CI 1.22–2.51), immunodepression (OR 1.98, 95% CI 1.27–3.08), time between hospital and ICU admission > 1 day (OR 2.02, 95% CI 1.44–2.99), a motor component on the GCS ≤ 3 (OR 2.23, 95% CI 1.49–3.45), hemiparesis/hemiplegia (OR 2.48, 95% CI 1.47–4.18), respiratory failure (OR 1.76, 95% CI 1.05–2.94), and cardiovascular failure (OR 1.72, 95% CI 1.07–2.75). In contrast, administration of a third-generation cephalosporin (OR 0.54, 95% CI 0.37–0.
Published: 2023

11. Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study

Author: Bedet, Alexandre, Tomberli, Françoise, Prat, Gwenael, Bailly, Pierre, Kouatchet, Achille, Mortaza, Sater, Vivier, Emmanuel, Rosselli, Sylvene, Lipskaia, Larissa, Carteaux, Guillaume, Razazi, Keyvan, and Mekontso Dessap, Armand
Published: 2019
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12. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial

Author: Landais, Mickaël, primary, Nay, Mai-Anh, additional, Auchabie, Johann, additional, Hubert, Noemie, additional, Frerou, Aurélien, additional, Yehia, Aihem, additional, Mercat, Alain, additional, Jonas, Maud, additional, Martino, Frédéric, additional, Moriconi, Mikael, additional, Courte, Anne, additional, Robert-Edan, Vincent, additional, Conia, Alexandre, additional, Bavozet, Florent, additional, Egreteau, Pierre-Yves, additional, Bruel, Cédric, additional, Renault, Anne, additional, Huet, Olivier, additional, Feller, Marc, additional, Chudeau, Nicolas, additional, Ferrandiere, Martine, additional, Rebion, Anne, additional, Robert, Alain, additional, Giraudeau, Bruno, additional, Reignier, Jean, additional, Thille, Arnaud W, additional, Tavernier, Elsa, additional, Ehrmann, Stephan, additional, MORTAZA, Satar, additional, DEMISELLE, Julien, additional, SASSI, Taoufik, additional, DELALE, Charles, additional, GROUILLE, Julien, additional, DE TINTENIAC, Anne, additional, GESLAIN, Marie, additional, FLOCH, Herve, additional, BAILLY, Pierre, additional, BODENES, Laetitia, additional, PRAT, Gwenaël, additional, KALFON, Pierre, additional, BADRE, Gaetan, additional, JOURDAIN, Cecile, additional, MAZZONI, Thierry, additional, LE MEUR, Anthony, additional, FAYOLLE, Pierre Marie, additional, HERON, Anne, additional, MAILLET, Odile, additional, LEDOUX, Nelly, additional, ROLLE, Amélie, additional, RICHARD, Régine, additional, VALETTE, Marc, additional, AZAIS, Marie-Ange, additional, POUPLET, Caroline, additional, BACHOUMAS, Konstantinos, additional, CALLAHAN, Jean Christophe, additional, GUITTON, Christophe, additional, DARREAU, Cedric, additional, LEFEVRE, Montaine, additional, LELOUP, Guillaume, additional, BERTEL, Mélanie, additional, DAUVERGNE, Jerome, additional, PACAUD, Laurence, additional, LAKHAL, Karim, additional, MARTIN, Maelle, additional, GARRET, Charlotte, additional, LASCARROU, Jean-Baptiste, additional, BOULAIN, Thierry, additional, MATHONNET, Armelle, additional, MULLER, Grégoire, additional, PHILIPPART, François, additional, TRAN, Marc, additional, FOURNIER, Julien, additional, FRAT, Jean-Pierre, additional, COUDROY, Remi, additional, CHATELLIER, Delphine, additional, HALLEY, Guillaume, additional, GACOUIN, Arnaud, additional, HOFF, Jerome, additional, VASTAL, Servane, additional, TELLIER, Anne-Charlotte, additional, BARBAZ, Mathilde, additional, SALMON GANDONNIERE, Charlotte, additional, MERCIER, Emmanuelle, additional, and DARWICHE, Walid, additional
Published: 2023
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13. Post-resuscitation care following cardiac arrest in intensive care units: a French national survey

Author: de Longeaux, Kahaia, primary and Bailly, Pierre, additional
Published: 2023
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14. A 19-Year Record of Training Haitian Residents in Otorhinolaryngology and Cervicofacial Surgery

Author: Dupret-Bories, Agnès, Jean-Gilles, Patrick, Malebranche, Rodolphe, Charpiot, Anne, Hémar, Patrick, Gentine, André, Boidevezi, Dominique, Rohmer, Dominique, Debry, Christian, Cadet, Jean-Claude, Bodin, Fréderic, and Bailly, Pierre
Published: 2015
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15. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author: Coupet, Randy, primary, Schläpfer, Martin, additional, Neff, Thomas A., additional, Boucher, Pierre, additional, Bailly, Pierre, additional, Bellgardt, Martin, additional, Badenes, Rafael, additional, Carbonell, Jose, additional, Becher, Tobias, additional, Varillon, Caroline, additional, Morand, Dominique, additional, Blondonnet, Raiko, additional, Constantin, Jean-Michel, additional, Pereira, Bruno, additional, O'Gara, Brian, additional, and Jabaudon, Matthieu, additional
Published: 2022
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16. Electrocardiographic Changes at the Early Stage of Status Epilepticus: First Insights From the ICTAL Registry*

Author: Chinardet, Paul, primary, Gilles, Floriane, additional, Cochet, Helene, additional, Chelly, Jonathan, additional, Quenot, Jean-Pierre, additional, Jacq, Gwenaelle, additional, Soulier, Pauline, additional, Lesieur, Olivier, additional, Beuret, Pascal, additional, Holleville, Mathilde, additional, Bruel, Cedric, additional, Bailly, Pierre, additional, Sauneuf, Bertrand, additional, Sejourne, Caroline, additional, Galbois, Arnaud, additional, Fontaine, Candice, additional, Perier, François, additional, Pichon, Nicolas, additional, Arrayago, Marine, additional, Mongardon, Nicolas, additional, Schnell, David, additional, Lascarrou, Jean-Baptiste, additional, Convers, Raphaële, additional, and Legriel, Stephane, additional
Published: 2022
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17. The use of computerized echocardiographic simulation improves the learning curve for transesophageal hemodynamic assessment in critically ill patients

Author: Prat, Gwénaël, Charron, Cyril, Repesse, Xavier, Coriat, Pierre, Bailly, Pierre, L’her, Erwan, and Vieillard-Baron, Antoine
Published: 2016
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18. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author: Coupet, Randy; https://orcid.org/0000-0002-6314-5827, Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin; https://orcid.org/0000-0001-9447-0019, Badenes, Rafael; https://orcid.org/0000-0001-7017-0150, Carbonell, Jose; https://orcid.org/0000-0001-7837-3868, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko; https://orcid.org/0000-0001-9881-8422, Constantin, Jean-Michel, Pereira, Bruno; https://orcid.org/0000-0003-3778-7161, O'Gara, Brian, Jabaudon, Matthieu; https://orcid.org/0000-0002-8121-1680, Coupet, Randy; https://orcid.org/0000-0002-6314-5827, Schläpfer, Martin; https://orcid.org/0000-0003-4288-7124, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin; https://orcid.org/0000-0001-9447-0019, Badenes, Rafael; https://orcid.org/0000-0001-7017-0150, Carbonell, Jose; https://orcid.org/0000-0001-7837-3868, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko; https://orcid.org/0000-0001-9881-8422, Constantin, Jean-Michel, Pereira, Bruno; https://orcid.org/0000-0003-3778-7161, O'Gara, Brian, and Jabaudon, Matthieu; https://orcid.org/0000-0002-8121-1680
Abstract: Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28. Keywords: coronavirus disease 2019; acute respiratory distress syndrome; inhaled sedation; sevoflurane; isoflurane
Published: 2022

19. Electrocardiographic Changes at the Early Stage of Status Epilepticus: First Insights From the ICTAL Registry*.

Author: Chinardet, Paul, Gilles, Floriane, Cochet, Helene, Chelly, Jonathan, Quenot, Jean-Pierre, Jacq, Gwenaelle, Soulier, Pauline, Lesieur, Olivier, Beuret, Pascal, Holleville, Mathilde, Bruel, Cedric, Bailly, Pierre, Sauneuf, Bertrand, Sejourne, Caroline, Galbois, Arnaud, Fontaine, Candice, Perier, François, Pichon, Nicolas, Arrayago, Marine, and Mongardon, Nicolas
Published: 2023
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20. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study

Author: Coupet, Randy, Schläpfer, Martin, Neff, Thomas A, Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin, Badenes, Rafael, Carbonell, Jose, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko, Constantin, Jean-Michel, Pereira, Bruno, O'Gara, Brian, Jabaudon, Matthieu, and University of Zurich
Subjects: 10216 Institute of Anesthesiology, coronavirus disease 2019, acute respiratory distress syndrome, inhaled sedation, sevoflurane, isoflurane, 610 Medicine & health, General Medicine, 10052 Institute of Physiology
Abstract: Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28.
Published: 2022
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21. High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial

Author: Rémi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, Frédéric Pène, Maxens Decavèle, Nicolas Terzi, Gwenaël Prat, Charlotte Garret, Damien Contou, Arnaud Gacouin, Jeremy Bourenne, Christophe Girault, Christophe Vinsonneau, Jean Dellamonica, Guylaine Labro, Sébastien Jochmans, Alexandre Herbland, Jean-Pierre Quenot, Jérôme Devaquet, Dalila Benzekri, Emmanuel Vivier, Saad Nseir, Gwenhaël Colin, Didier Thevenin, Giacomo Grasselli, David Bougon, Mona Assefi, Claude Guérin, Thierry Lherm, Achille Kouatchet, Stephanie Ragot, Arnaud W Thille, Chatellier Delphine, Veinstein Anne, Boissier Florence, Reynaud Faustine, Rodriguez Maeva, Joly Florent, Arrivé François, De Roubin Victor, Robert René, Bodet-Contentin Laetitia, Salmon Gandonnière Charlotte, Mercier Emmanuelle, Jaubert Paul, Marin Nathalie, Paul Marine, Faure Morgane, Demiri Suela, Demoule Alexandre, Candille Clara, Dartevel Anaïs, Sigaud Florian, Jean Michel Vanessa, Le Mao Raphaël, Bailly Pierre, Seguin Amélie, Lascarrou Jean-Baptiste, Canet Emmanuel, Plantefève Gaëtan, Cally Radj, Tirolien Joanna, Maamar Adel, Painvin Benoit, Carvelli Julien, Gainnier Marc, Béduneau Gaëtan, Carpentier Dorothée, Malacrino Dominique, Marzouk Mehdi, Saccheri Clément, Mahr Nicolas, Soulier Pauline, Levrat Quentin, Andreu Pascal, Cortier David, and Nay Mai Anh
Subjects: Pulmonary and Respiratory Medicine, Adult, Oxygen, Immunocompromised Host, Respiratory Distress Syndrome, Noninvasive Ventilation, Critical Illness, Oxygen Inhalation Therapy, Settore MED/41 - Anestesiologia, Humans, Respiratory Insufficiency
Abstract: Although non-invasive ventilation (NIV) is recommended for immunocompromised patients with acute respiratory failure in the intensive care unit (ICU), it might have deleterious effects in the most severe patients. High-flow nasal oxygen (HFNO) alone might be an alternative method to reduce mortality. We aimed to determine whether HFNO alone could reduce the rate of mortality at day 28 compared with HFNO alternated with NIV.FLORALI-IM is a multicentre, open-label, randomised clinical trial conducted in 29 ICUs (28 in France and one in Italy). Adult immunocompromised patients with acute respiratory failure, defined as respiratory rate of 25 breaths per min or more and a partial pressure of arterial oxygen to inspired fraction of oxygen ratio of 300 mm Hg or lower, were randomly assigned (1:1) to HFNO alone (HFNO alone group) or NIV alternating with HFNO (NIV group). Key exclusion criteria were severe hypercapnia above 50 mm Hg, patients who could strongly benefit from NIV (ie, those with underlying chronic lung disease, with cardiogenic pulmonary oedema, or who were postoperative), severe shock, impaired consciousness defined as Glasgow coma score ≤12, urgent need for intubation, do not intubate order, and contraindication to NIV. Patients were assigned using computer-generated permuted blocks and were stratified according to centre and to the type of immunosuppression using a centralised web-based management system. In the HFNO alone group, patients were continuously treated by HFNO with a gas flow rate of 60 L/min or the highest tolerated. In the NIV group, patients were treated with NIV with a first session of at least 4 h, and then by sessions for a minimal duration of 12 h a day, with a dedicated ventilator, targeting a tidal volume below 8 mL/kg of predicted bodyweight, and with a positive end-expiratory level of at least 8 cm HBetween Jan 21, 2017 to March 4, 2019, of 497 eligible patients, 300 were randomly assigned but one patient withdrew consent, leaving 299 patients included in the intention-to-treat analysis (154 assigned to the HFNO alone group and 145 assigned to NIV group). Mortality rate at day 28 was 36% (95% CI 29·2 to 44·2; 56 of 154 patients) in the HFNO alone group and 35% (27·9 to 43·2; 51 of 145 patients) in the NIV group (absolute difference 1·2% [95% CI -9·6 to 11·9]; p=0·83). None of the other prespecified secondary outcomes were different between groups except for greater decreased discomfort after initiation of HFNO than with NIV (-4 mm on visual analogic scale [IQR -18 to 4] vs 0 mm [-16 to 17]; p=0·040).In critically ill immunocompromised patients with acute respiratory failure, the mortality rate did not differ between HFNO alone and NIV alternating with HFNO. However, study power was limited, so results should be interpreted with caution.French Ministry of Health.
Published: 2021

22. Non-invasive ventilation versus high-flow nasal oxygen for postextubation respiratory failure in ICU: a post-hoc analysis of a randomized clinical trial

Author: Thille, Arnaud, Monseau, Grégoire, Coudroy, Rémi, Nay, Mai-Anh, Gacouin, Arnaud, Decavèle, Maxens, Sonneville, Romain, Beloncle, François, Girault, Christophe, Dangers, Laurence, Lautrette, Alexandre, Levrat, Quentin, Rouzé, Anahita, Vivier, Emmanuel, Lascarrou, Jean-Baptiste, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Massri, Alexandre, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Robert, René, Ragot, Stéphanie, Frat, Jean-Pierre, Boissier, Florence, Chatellier, Delphine, Deletage, Céline, Guignon, Carole, Joly, Florent, Olivry, Morgane, Veinstein, Anne, Benzekri-Lefevre, Dalila, Boulain, Thierry, Muller, Grégoire, Le Tulzo, Yves, Tadié, Jean-Marc, Maamar, Adel, Demiri, Suela, Mayaux, Julien, Demoule, Alexandre, Bouadma, Lila, Dupuis, Claire, Asfar, Pierre, Pierrot, Marc, Béduneau, Gaëtan, Boyer, Déborah, Delmas, Benjamin, Puech, Bérénice, Bachoumas, Konstantinos, Soum, Edouard, Cabasson, Séverin, Hoppe, Marie-Anne, Nseir, Saad, Pouly, Olivier, Bourdin, Gaël, Rosselli, Sylvène, Le Meur, Anthony, Garret, Charlotte, Martin, Maelle, Berquier, Guillaume, Thiagarajah, Abirami, Carteaux, Guillaume, Mekontso-Dessap, Armand, Poidevin, Antoine, Dureau, Anne-Florence, Azais, Marie-Ange, Colin, Gwenhaël, Mercier, Emmanuelle, Morisseau, Marlène, Sabatier, Caroline, Picard, Walter, Gainnier, Marc, Nguyen, Thi-My-Hue, Prat, Gwenaël, Schwebel, Carole, Buscot, Matthieu, Service de Médecine Intensive Réanimation [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, chemistry.chemical_element, Airway Extubation, Kaplan-Meier Estimate, Critical Care and Intensive Care Medicine, Acute respiratory failure, Oxygen, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Ventilator weaning, Intensive care, Post-hoc analysis, Medicine, Humans, Aged, Aged, 80 and over, Noninvasive Ventilation, RC86-88.9, business.industry, Research, Airway extubation, Oxygen Inhalation Therapy, Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, Oxygenation, Length of Stay, Middle Aged, High-flow nasal oxygen, 3. Good health, Intensive Care Units, 030228 respiratory system, Respiratory failure, chemistry, Anesthesia, Female, medicine.symptom, business, Respiratory Insufficiency, Hypercapnia
Abstract: Background In intensive care units (ICUs), patients experiencing post-extubation respiratory failure have poor outcomes. The use of noninvasive ventilation (NIV) to treat post-extubation respiratory failure may increase the risk of death. This study aims at comparing mortality between patients treated with NIV alternating with high-flow nasal oxygen or high-flow nasal oxygen alone. Methods Post-hoc analysis of a multicenter, randomized, controlled trial focusing on patients who experienced post-extubation respiratory failure within the 7 days following extubation. Patients were classified in the NIV group or the high-flow nasal oxygen group according to oxygenation strategy used after the onset of post-extubation respiratory failure. Patients reintubated within the first hour after extubation and those promptly reintubated without prior treatment were excluded. The primary outcome was mortality at day 28 after the onset of post-extubation respiratory failure. Results Among 651 extubated patients, 158 (25%) experienced respiratory failure and 146 were included in the analysis. Mortality at day 28 was 18% (15/84) using NIV alternating with high-flow nasal oxygen and 29% (18/62) with high flow nasal oxygen alone (difference, − 11% [95% CI, − 25 to 2]; p = 0.12). Among the 46 patients with hypercapnia at the onset of respiratory failure, mortality at day 28 was 3% (1/33) with NIV and 31% (4/13) with high-flow nasal oxygen alone (difference, − 28% [95% CI, − 54 to − 6]; p = 0.006). The proportion of patients reintubated 48 h after the onset of post-extubation respiratory failure was 44% (37/84) with NIV and 52% (32/62) with high-flow nasal oxygen alone (p = 0.21). Conclusions In patients with post-extubation respiratory failure, NIV alternating with high-flow nasal oxygen might not increase the risk of death. Trial registration number The trial was registered at http://www.clinicaltrials.gov with the registration number NCT03121482 the 20th April 2017.
Published: 2021

23. Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial

Author: Rodriguez, Maeva, Ragot, Stéphanie, Coudroy, Rémi, Quenot, Jean-Pierre, Vignon, Philippe, Forel, Jean-Marie, Demoule, Alexandre, Mira, Jean-Paul, Ricard, Jean-Damien, Nseir, Saad, Colin, Gwenhael, Pons, Bertrand, Danin, Pierre-Eric, Devaquet, Jérome, Prat, Gwenael, Merdji, Hamid, Petitpas, Franck, Vivier, Emmanuel, Mekontso-Dessap, Armand, Nay, Mai-Anh, Asfar, Pierre, Dellamonica, Jean, Argaud, Laurent, Ehrmann, Stephan, Fartoukh, Muriel, Girault, Christophe, Robert, René, Thille, Arnaud, Frat, Jean-Pierre, Chatellier, Delphine, Boissier, Florence, Veinstein, Anne, Dahyot-Fizelier, Claire, Dargent, Auguste, Large, Audrey, Begot, Emmanuelle, Mancia, Claire, Decavele, Maxence, Dres, Martin, Lehingue, Samuel, Papazian, Laurent, Paul, Marine, Marin, Nathalie, Le Meur, Matthieu, Laissy, Mohammed, Rouzé, Anahita, Henry-Lagarrigue, Matthieu, Yehia, Aihem, Martino, Frédéric, Cerf, Charles, Bailly, Pierre, Helms, Julie, Putegnat, Jean Baptiste, Razazi, Keyvan, Boulain, Thierry, Cabasson, Séverin, Wallet, Florent, Klouche, Kada, Bellec, Frédéric, Service de Médecine Intensive Réanimation [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_treatment, Respiratory failure, Critical Care and Intensive Care Medicine, medicine.disease_cause, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Hypoxemia, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, High-flow oxygen, law, Preoxygenation, Post-hoc analysis, medicine, Intubation, 030212 general & internal medicine, Obesity, Respiratory system, 2. Zero hunger, business.industry, RC86-88.9, Research, Medical emergencies. Critical care. Intensive care. First aid, 3. Good health, Intubation procedure, 030228 respiratory system, Anesthesia, Non-invasive ventilation, medicine.symptom, business, Nasal cannula
Abstract: Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m−2) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO2/FiO2 Results Among the 313 patients included in the original trial, 91 (29%) had obesity with a mean body mass index of 35 ± 5 kg·m−2. Patients with obesity were more likely to experience an episode of severe hypoxemia during intubation procedure than patients without obesity: 34% (31/91) vs. 22% (49/222); difference, 12%; 95% CI 1 to 23%; P = 0.03. Among patients with obesity, 40 received preoxygenation with noninvasive ventilation and 51 with high-flow nasal oxygen. Severe hypoxemia occurred in 15 patients (37%) with noninvasive ventilation and 16 patients (31%) with high-flow nasal oxygen (difference, 6%; 95% CI − 13 to 25%; P = 0.54). The lowest pulse oximetry values during intubation procedure were 87% [interquartile range, 77–93] with noninvasive ventilation and 86% [78–92] with high-flow nasal oxygen (P = 0.98). After multivariable analysis, factors independently associated with severe hypoxemia in patients with obesity were intubation difficulty scale > 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ventilation may not reduce this risk compared with high-flow nasal oxygen. Trial registration Clinical trial number: NCT02668458 (http://www.clinicaltrials.gov)
Published: 2021

24. Beneficial Effects of Noninvasive Ventilation after Extubation in Obese or Overweight Patients: A Post Hoc Analysis of a Randomized Clinical Trial

Author: Thille, Arnaud W., primary, Coudroy, Rémi, additional, Nay, Mai-Anh, additional, Gacouin, Arnaud, additional, Decavèle, Maxens, additional, Sonneville, Romain, additional, Beloncle, François, additional, Girault, Christophe, additional, Dangers, Laurence, additional, Lautrette, Alexandre, additional, Levrat, Quentin, additional, Rouzé, Anahita, additional, Vivier, Emmanuel, additional, Lascarrou, Jean-Baptiste, additional, Ricard, Jean-Damien, additional, Mekontso-Dessap, Armand, additional, Barberet, Guillaume, additional, Lebert, Christine, additional, Ehrmann, Stephan, additional, Massri, Alexandre, additional, Bourenne, Jeremy, additional, Pradel, Gael, additional, Bailly, Pierre, additional, Terzi, Nicolas, additional, Dellamonica, Jean, additional, Lacave, Guillaume, additional, Robert, René, additional, Frat, Jean-Pierre, additional, Ragot, Stéphanie, additional, Boissier, Florence, additional, Chatellier, Delphine, additional, Deletage, Céline, additional, Guignon, Carole, additional, Joly, Florent, additional, Olivry, Morgane, additional, Veinstein, Anne, additional, Benzekri-Lefevre, Dalila, additional, Boulain, Thierry, additional, Muller, Grégoire, additional, Le Tulzo, Yves, additional, Tadié, Jean-Marc, additional, Maamar, Adel, additional, Demiri, Suela, additional, Mayaux, Julien, additional, Demoule, Alexandre, additional, Bouadma, Lila, additional, Dupuis, Claire, additional, Asfar, Pierre, additional, Pierrot, Marc, additional, Béduneau, Gaëtan, additional, Boyer, Déborah, additional, Delmas, Benjamin, additional, Puech, Bérénice, additional, Bachoumas, Konstantinos, additional, Soum, Edouard, additional, Cabasson, Séverin, additional, Hoppe, Marie-Anne, additional, Nseir, Saad, additional, Pouly, Olivier, additional, Bourdin, Gaël, additional, Rosselli, Sylvène, additional, Le Meur, Anthony, additional, Garret, Charlotte, additional, Martin, Maelle, additional, Berquier, Guillaume, additional, Thiagarajah, Abirami, additional, Carteaux, Guillaume, additional, Razazi, Keyvan, additional, Poidevin, Antoine, additional, Dureau, Anne-Florence, additional, Azais, Marie-Ange, additional, Colin, Gwenhaël, additional, Mercier, Emmanuelle, additional, Morisseau, Marlène, additional, Sabatier, Caroline, additional, Picard, Walter, additional, Gainnier, Marc, additional, Nguyen, Thi-My-Hue, additional, Prat, Gwenaël, additional, Schwebel, Carole, additional, and Buscot, Matthieu, additional
Published: 2022
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25. Multicentre observational status-epilepticus registry: protocol for ICTAL

Author: Jacq, Gwenaelle, primary, Chelly, Jonathan, additional, Quenot, Jean-Pierre, additional, Soulier, Pauline, additional, Lesieur, Olivier, additional, Beuret, Pascal, additional, Holleville, Mathilde, additional, Bruel, Cedric, additional, Bailly, Pierre, additional, Sauneuf, Bertrand, additional, Sejourne, Caroline, additional, Rigaud, Jean Philippe, additional, Galbois, Arnaud, additional, Arrayago, Marine, additional, Plantefeve, Gaetan, additional, Stoclin, Annabelle, additional, Schnell, David, additional, Fontaine, Candice, additional, Perier, François, additional, Bougouin, Wulfran, additional, Pichon, Nicolas, additional, Mongardon, Nicolas, additional, Ledoux, Didier, additional, Lascarrou, Jean-Baptiste, additional, and Legriel, Stephane, additional
Published: 2022
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26. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial

Author: Ehrmann, Stephan, primary, Li, Jie, additional, Ibarra-Estrada, Miguel, additional, Perez, Yonatan, additional, Pavlov, Ivan, additional, McNicholas, Bairbre, additional, Roca, Oriol, additional, Mirza, Sara, additional, Vines, David, additional, Garcia-Salcido, Roxana, additional, Aguirre-Avalos, Guadalupe, additional, Trump, Matthew W, additional, Nay, Mai-Anh, additional, Dellamonica, Jean, additional, Nseir, Saad, additional, Mogri, Idrees, additional, Cosgrave, David, additional, Jayaraman, Dev, additional, Masclans, Joan R, additional, Laffey, John G, additional, Tavernier, Elsa, additional, Elshafei, Ahmad A, additional, Scott, Brady J, additional, Weiss, Tyler, additional, Kaur, Ramandeep, additional, Harnois, Lauren J, additional, Miller, Amanda, additional, Cerda, Flor, additional, Klein, Andrew, additional, Burd, Jacob R, additional, Posa-Kearney, Kathleen, additional, Trump, Matthew, additional, Jackson, Julie, additional, Oetting, Trevor, additional, Greenwood, Mark, additional, Hazel, Lindsay, additional, Kingery, Lisa, additional, Morris, Lindsey, additional, Moon, Joon Yong, additional, Garnett, Julianne, additional, Jia, Shijing, additional, Nelson, Kristine, additional, Giacomini, Camilla, additional, Laffey, John, additional, Brennan, Aoife, additional, Judge, Conor, additional, Kernan, Maeve, additional, Kelly, Claire, additional, Ranjan, Ritika, additional, Casey, Siobhan, additional, O'Connell, Kevin, additional, Newell, Evelyn, additional, Gallagher, David, additional, Nichol, Alistair, additional, Curley, Ger, additional, Estrada, Miguel Ibarra, additional, García-Salcido, Roxana, additional, Vargas-Obieta, Alexandra, additional, Aguirre-Díaz, Sara A, additional, Alcántar-Vallín, Luz, additional, Alvarado-Padilla, Montserrat, additional, Chávez-Peña, Quetzalcóatl, additional, López-Pulgarín, José A, additional, Mijangos-Méndez, Julio C, additional, Marín-Rosales, Miguel, additional, García-Alvarado, Jorge E, additional, Baltazar-González, Oscar G, additional, González-Guerrero, Maura C, additional, Gutiérrez Ramírez, Paola G, additional, Gilman, Sean, additional, Plamondon, Patrice, additional, Roy, Rachel, additional, Shahin, Jason, additional, Ragoshai, Raham, additional, Kaur, Aasmine, additional, Campisi, Josie, additional, Dahine, Joseph, additional, Perron, Stefanie, additional, Achouri, Slimane, additional, Racette, Ronald, additional, Kulenkamp, Anne, additional, Pacheco, Andrés, additional, García-de-Acilu, Marina, additional, Dot, Irene, additional, Bodet-Contentin, Laetitia, additional, Garot, Denis, additional, Ehrmann, Stephan, additional, Mercier, Emmanuelle, additional, Salmon Gandonnière, Charlotte, additional, Morisseau, Marlène, additional, Jouan, Youenn, additional, Darwiche, Walid, additional, Legras, Annick, additional, Guillon, Antoine, additional, Dequin, Pierre-François, additional, Tellier, Anne-Charlotte, additional, Reignier, Jean, additional, Lascarrou, Jean-Baptiste, additional, Seguin, Amélie, additional, Desmedt, Luc, additional, Canet, Emmanuel, additional, Guitton, Christophe, additional, Marnai, Rémy, additional, Callahan, Jean-Christophe, additional, Landais, Mickaël, additional, Chudeau, Nicolas, additional, Darreau, Cédric, additional, Tirot, Patrice, additional, Saint Martin, Marjorie, additional, Le Moal, Charlene, additional, Muller, Grégoire, additional, Jacquier, Sophie, additional, Prat, Gwenaël, additional, Bailly, Pierre, additional, Ferrière, Nicola, additional, Thille, Arnaud W, additional, Frat, Jean-Pierre, additional, Saccheri, Clément, additional, Buscot, Matthieu, additional, Plantefève, Gaëtan, additional, Contou, Damien, additional, Roux, Damien, additional, Ricard, Jean-Damien, additional, Federici, Laura, additional, Zucman, Noémie, additional, Freita Ramos, Santiago, additional, Amouretti, Marc, additional, Besset, Sébastien, additional, Gernez, Coralie, additional, Delbove, Agathe, additional, Voiriot, Guillaume, additional, Elabbadi, Alexandre, additional, Fartoukh, Muriel, additional, Préau, Sébastien, additional, Favory, Raphaël, additional, Pierre, Alexandre, additional, Sement, Arnaud, additional, Terzi, Nicolas, additional, Sigaud, Florian, additional, Candille, Clara, additional, Turbil, Emanuele, additional, Maizel, Julien, additional, Brault, Clément, additional, Zerbib, Yoan, additional, Joret, Aurélie, additional, Daubin, Cédric, additional, Lefebvre, Laurent, additional, Giraud, Alais, additional, Auvet, Adrien, additional, Vinsonneau, Christophe, additional, Marzouk, Mehdi, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Labruyère, Marie, additional, Roudaut, Jean-Baptiste, additional, Aptel, François, additional, Boyer, Alexandre, additional, Boyer, Philippe, additional, Lacherade, Jean-Claude, additional, Hille, Hugo, additional, Bouteloup, Marie, additional, Jeannot, Matthieu, additional, Feller, Marc, additional, Grillet, Guillaume, additional, Levy, Bruno, additional, and Kimmoun, Antoine, additional
Published: 2021
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27. Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis.

Author: Jeantin, Lina, Dupuis, Claire, Vellieux, Geoffroy, Jaquet, Pierre, de Montmollin, Etienne, Timsit, Jean-François, Sonneville, Romain, the ENCEPHALITICA Study Group, Alves, Mikael, Argaud, Laurent, Bailly, Pierre, Barbier, François, Bouadma, Lila, Brulé, Noelle, Bruneel, Fabrice, Chabanne, Russell, Conrad, Marie, da Silva, Daniel, Dailler, Frederic, and Daubin, Delphine
Subjects: HERPES simplex, ELECTROENCEPHALOGRAPHY, ENCEPHALITIS, DISABILITIES, AUDITORY perception, VIRAL encephalitis, EPILEPSY
Abstract: Background: Electroencephalography (EEG) is recommended for the practical approach to the diagnosis and prognosis of encephalitis. We aimed to investigate the prognostic value of standard EEG (stdEEG) in adult patients with severe herpes simplex encephalitis. Methods: We performed a retrospective analysis of consecutive ICU patients with severe herpes simplex encephalitis in 38 French centers between 2006 and 2016. Patients with at least one stdEEG study performed at ICU admission were included. stdEEG findings were reviewed independently by two investigators. The association between stdEEG findings (i.e., background activity, lateralized periodic discharges, seizures/status epilepticus, and reactivity to painful/auditory stimuli) and poor functional outcome, defined by a score on the modified Rankin Scale (mRS) of 3 to 6 (moderate to severe disability or death) at 90 days, were investigated. Results: We included 214 patients with at least one available stdEEG study. The first stdEEG was performed after a median time of one (interquartile range (IQR) 0 to 2) day from ICU admission. At the time of recording, 138 (64.5%) patients were under invasive mechanical ventilation. Lateralized periodic discharges were recorded in 91 (42.5%) patients, seizures in 21 (9.8%) and status epilepticus in 16 (7.5%). In the whole population, reactivity to auditory/noxious stimuli was tested in 140/214 (65.4%) patients and was absent in 71/140 (33.2%) cases. In mechanically ventilated patients, stdEEG reactivity was tested in 91/138 (65.9%) subjects, and was absent in 53/91 (58.2%) cases. Absence of reactivity was the only independent stdEEG finding associated with poor functional outcome in the whole population (OR 2.80, 95% CI 1.19 to 6.58) and in the subgroup of mechanically ventilated patients (OR 4.99, 95% CI 1.6 to 15.59). Adjusted analyses for common clinical predictors of outcome and sedation at time of stdEEG revealed similar findings in the whole population (OR 2.03, 95% CI 1.18 to 3.49) and in mechanically ventilated patients (OR 2.62, 95% CI 1.25 to 5.50). Conclusions: Absence of EEG reactivity to auditory/noxious stimuli is an independent marker of poor functional outcome in severe herpes simplex encephalitis. [ABSTRACT FROM AUTHOR]
Published: 2023
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28. Inhaled Sedation in Patients with COVID-19-Related Acute Respiratory Distress Syndrome: An International Retrospective Study †.

Author: Coupet, Randy, Schläpfer, Martin, Neff, Thomas A., Boucher, Pierre, Bailly, Pierre, Bellgardt, Martin, Badenes, Rafael, Carbonell, Jose, Becher, Tobias, Varillon, Caroline, Morand, Dominique, Blondonnet, Raiko, Constantin, Jean-Michel, Pereira, Bruno, O'Gara, Brian, and Jabaudon, Matthieu
Subjects: ADULT respiratory distress syndrome, COVID-19, PROPENSITY score matching, INTENSIVE care units, CONSCIOUS sedation
Abstract: Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic and the shortage of intravenous sedatives has led to renewed interest in inhaled sedation for patients with acute respiratory distress syndrome (ARDS). We hypothesized that inhaled sedation would be associated with improved clinical outcomes in COVID-19 ARDS patients. Methods: Retrospective international study including mechanically ventilated patients with COVID-19 ARDS who required sedation and were admitted to 10 European and US intensive care units. The primary endpoint of ventilator-free days through day 28 was analyzed using zero-inflated negative binomial regression, before and after adjustment for site, clinically relevant covariates determined according to the univariate results, and propensity score matching. Results: A total of 196 patients were enrolled, 78 of whom died within 28 days. The number of ventilator-free days through day 28 did not differ significantly between the patients who received inhaled sedation for at least 24 h (n = 111) and those who received intravenous sedation only (n = 85), with medians of 0 (interquartile range [IQR] 0–8) and 0 (IQR 0–17), respectively (odds ratio for having zero ventilator-free days through day 28, 1.63, 95% confidence interval [CI], 0.91–2.92, p = 0.10). The incidence rate ratio for the number of ventilator-free days through day 28 if not 0 was 1.13 (95% CI, 0.84–1.52, p = 0.40). Similar results were found after multivariable adjustment and propensity matching. Conclusion: The use of inhaled sedation in COVID-19 ARDS was not associated with the number of ventilator-free days through day 28. [ABSTRACT FROM AUTHOR]
Published: 2023
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29. Décrire les interrelations économiques : la comptabilité nationale

Author: Bailly, Pierre, Bailly, Pierre, Bailly, Pierre, and Bailly, Pierre
Abstract: Les critiques actuelles à l'égard des données économiques entretiennent une atmosphère de méfiance à l'égard de l'indicateur central de la mesure de la croissance : le PIB. Les controverses sur sa signification apparaissent d'autant plus obscures que son calcul est mal connu ou mal interprété. Une connaissance minimale de la Comptabilité nationale permet d'appréhender les apports et les limites de cet indicateur phare des débats économiques, politiques et sociaux.
Published: 2019

30. Outcomes in Patients With COVID-19 With Acute Encephalopathy and Coma

Author: Legriel, Stephane, Badenes, Rafael, Engrand, Nicolas, Mendoza-Trujillo, Rocio, Soulier, Pauline, Benghanem, Sarah, Pizzi, Michael, Maciel, Carolina, Chelly, Jonathan, Zuber, Benjamin, Labruyere, Marie, Plantefeve, Gaetan, Jacq, Gwenaëlle, Galbois, Arnaud, Launey, Yoann, Argaud, Laurent, Lesieur, Olivier, Ferre, Alexis, Paul, Marine, Guillon, Antoine, Bailly, Pierre, Beuret, Pascal, de-Carne, Marie-Charlotte, Siami, Shidasp, Benzekri, Dalila, Colin, Gwenhael, Gaviria, Leidy, Aldana, Jose Luis, Bruel, Cedric, Stoclin, Annabelle, Sedillot, Nicholas, Geri, Guillaume, Samano, Daniel, Sobczak, Evie, Swafford, Emily, O'Phelan, Kristine, Meffert, Arnaud, Holleville, Mathilde, Silva, Stein, Alves da Costa, Manoel José, Mejia, Jorge, Alkhachroum, Ayham, Bruneel, Fabrice, Lopez, Berta Monleon-, Monchi, Mehran, Cariou, Alain, Cerf, Charles, Quenot, Jean-Pierre, Tadie, Jean-Marc, Lher, Erwan, Belan, Alix Greder-, Muller, Gregoire, Baron, Antoine Vieillard-, and Mongardon, Nicolas
Published: 2023
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31. Coemploi et responsabilité

Author: Ranc, Sébastien and Bailly, Pierre
Subjects: 3-3- Droit administratif, 4-3- Droit social – droit du travail, 4-2- Droit des affaires – droit commercial
Abstract: Les deux arrêts que la chambre sociale a rendus le 25 novembre 2020, en formation plénière, sur les pourvois n° 18-13.769 et 18- 13.771, offrent l’occasion de s’interroger sur l’état actuel du coemploi, dont la mort avait été annoncée ou désirée, et sur les autres moyens dont disposent des salariés licenciés pour motif économique, lorsqu’ils entendent imputer la perte de leur emploi à un comportement fautif de leur employeur ou d’un tiers. Cette interrogation est d’autant plus nécessaire, que depuis une dizaine d’années, des évolutions se sont produites dans l’approche de la chambre sociale, qui ont donné lieu à de nombreux commentaires doctrinaux. La note explicative diffusée sur le site public de la Cour de cassation rappelle en partie les étapes de cette évolution. Institution décriée par une partie de la doctrine parce qu’elle mettrait en péril les principes qui s’attachent à la personnalité morale et, particulièrement, la séparation et l’autonomie des patrimoines, elle a été victime d’un succès d’estime excessif de la part de certains salariés, au point que des ajustements sont apparus nécessaires pour en marquer les limites. Mais alors que, dans la première affaire, l’Avocat général invitait la chambre sociale à l’abandonner, par un « retour aux sources » fondé sur le seul critère de la subordination et sur le régime de la responsabilité civile délictuelle, le coemploi est toujours là, même s’il a perdu de sa vigueur. Il s’agira donc d’analyser les évolutions qu’il a connues et leurs raisons, puis, d’évoquer, notamment à partir du second arrêt, les autres actions qui sont ouvertes aux salariés licenciés lorsqu’ils entendent dénoncer des manquements ayant contribué à la perte de leur emploi.
Published: 2021

32. Additional file 1 of Non-invasive ventilation versus high-flow nasal oxygen for postextubation respiratory failure in ICU: a post-hoc analysis of a randomized clinical trial

Author: Thille, Arnaud W., Monseau, Grégoire, Coudroy, Rémi, Nay, Mai-Anh, Gacouin, Arnaud, Decavèle, Maxens, Sonneville, Romain, Beloncle, François, Girault, Christophe, Dangers, Laurence, Lautrette, Alexandre, Levrat, Quentin, Rouzé, Anahita, Vivier, Emmanuel, Lascarrou, Jean-Baptiste, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Massri, Alexandre, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Robert, René, Ragot, Stéphanie, and Frat, Jean-Pierre
Subjects: health care facilities, manpower, and services
Abstract: Additional file 1. Comparison between patients who were discharged alive from ICU and those who died in ICUs after post-extubation respiratory failure.
Published: 2021
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33. Conditions de travail 2021-2022. Durée, rémunération, santé et sécurité

Author: Bailly, Pierre, Blatman, Michel, Pignarre, Geneviève, Vericel, Marc, VITALIEN-CHARBONNEL, Audrey, Dalloz, Centre Michel de l'Hospital : laboratoire de recherche en sciences juridiques et politiques (CMH ), Université Clermont Auvergne (UCA), Centre de Recherches Critiques sur le Droit (CERCRID), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: réglementation des relations de travail, santé au travail, [SHS.DROIT] Humanities and Social Sciences/Law, droits et libertés des salariés, rémunération, exercice des pouvoirs patronaux, droit des conditions de travail, accords collectifs, droit européen, sécurité au travail, [SHS.DROIT]Humanities and Social Sciences/Law, ordonnances du 22 septembre 2017, durée de travail, jurisprudence des juridictions suprêmes nationales, catégories de salariés vulnérables, conditions de travail, droit légiféré interne, législation du travail, ComputingMilieux_MISCELLANEOUS, exploitation, jurisprudence des juridictions suprêmeseuropéennes, loi du 8 août 2016
Abstract: International audience; Le droit des conditions de travail constitue l'un des volets majeurs de la réglementation des relations de travail depuis son origine. C'est d'ailleurs parce qu'est apparue la nécessité d'encadrer la durée et l'organisation du travail, la rémunération des salariés, leur santé et leur sécurité, pour assurer leur protection contre une exploitation abusive de leur force de travail, qu'a été élaborée une législation du travail. La réglementation des conditions de travail s'est étendue, au-delà du temps de travail, de la santé au travail et de la fixation de la rémunération, à la protection de certaines catégories de salariés particulièrement vulnérables (la femme enceinte, le salarié devenu inapte, le travailleur handicapé), à l'exercice des pouvoirs patronaux et à celui des droits et libertés des salariés dans l'entreprise. - Le droit des conditions de travail est, néanmoins, traité fort succinctement dans les manuels de droit du travail et bien peu d'ouvrages lui sont consacrés ou lui donnent une place importante ; cela alors même que les différents volets de ce droit regroupent des ensembles de normes très techniques et fort complexes à mettre en oeuvre en pratique. Cet ouvrage s'efforce de traiter de l'ensemble des questions pratiques liées aux divers domaines relevant de la réglementation des conditions de travail. Son approche, à la fois théorique et concrète, fait évidemment une large place, à côté du droit légiféré interne, au droit européen, à la jurisprudence des juridictions suprêmes nationales et européennes, aux positions de la doctrine, ainsi qu'aux accords collectifs les plus importants. Cet ouvrage arrive à point nommé pour inclure de nombreuses réformes importantes, notamment la loi du 8 aoßt 2016 relative au travail, à la modernisation du dialogue social et à la sécurisation des parcours professionnels ; et aux ordonnances du 22 septembre 2017, dites Macron, ainsi que leurs décrets d'application. - Cet ouvrage a vocation à constituer, dans son domaine, l'outil de référence de l'ensemble des professionnels et des praticiens du droit des relations de travail : avocats, magistrats, conseils juridiques d'entreprise, directeurs des ressources humaines, représentants du personnel, syndicats, qui devraient y trouver la solution à de nombreuses questions qu'ils rencontrent dans la pratique, ainsi qu'aux enseignants chercheurs et étudiants en droit social. - Cet ouvrage a été réalisé par quatre spécialistes de la matière.
Published: 2021

34. High-flow nasal cannula therapy: clinical practice in intensive care units

Author: Thille, Arnaud, Muller, Grégoire, Gacouin, Arnaud, Coudroy, Rémi, Decavele, Maxens, Sonneville, Romain, Beloncle, Francois, Dangers, Laurence, Lautrette, Alexandre, Cabasson, Séverin, Rouzé, Anahita, Vivier, Emmanuel, Le Meur, Anthony, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Sabatier, Caroline, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Danin, Pierre-Eric, Nanadoumgar, Hodanou, Gibelin, Aude, Zanre, Lassane, Deye, Nicolas, Demoule, Alexandre, Maamar, Adel, Nay, Mai-Anh, Robert, Rene, Ragot, Stéphanie, Frat, Jean-Pierre, Besnier, Emmanuel, Hobeika, Sinad, Nseir, Saad, Lambiotte, Fabien, Du Cheyron, Damien, Sauneuf, Bertrand, Misset, Benoît, Tamion, Fabienne, Schnell, Guillaume, Richecoeur, Jack, Maizel, Julien, Girault, Christophe, Réanimation Médicale, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Sorbonne Université (SU), Hôpital Bichat - Claude Bernard, Service de Réanimation Médicale et de Médecine Hyperbare [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Centre hospitalier Saint Joseph - Saint Luc [Lyon], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Départemental Les Oudairies, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de réanimation médicale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Inserm U1065, Centre Méditerranéen de Médecine Moléculaire, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Immunologie antivirale systémique et cérébrale, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Réanimation, Hôpital Jean Bernard, CHU de Poitiers, Poitiers, France, UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Soins Intensifs [CHU Caen], Centre Hospitalier Public du Cotentin (CHPC), CHU Rouen, Normandie Université (NU), Service de réanimation médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Unité Médicale de Soins Intensifs, CHU Amiens-Picardie, Groupe de Recherche sur le Handicap Ventilatoire (GRHV), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-CHU Rouen, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), CH Centre Hospitalier Public du Cotentin (CHPC), Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), and Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, medicine.medical_treatment, Critical Care and Intensive Care Medicine, medicine.disease_cause, Acute respiratory failure, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Hypoxemia, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Oxygen therapy, Intensive care, Anesthesiology, medicine, Intubation, Intensive care unit, ComputingMilieux_MISCELLANEOUS, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, lcsh:RC86-88.9, 3. Good health, 030228 respiratory system, Clinical practices, Emergency medicine, High-flow nasal cannula, medicine.symptom, business, Nasal cannula, Hypercapnia
Abstract: Background Despite the extensive use of high-flow nasal cannula (HFNC) therapy in intensive care units (ICU) for acute respiratory failure (ARF), its daily clinical practice has not been assessed. We designed a regional survey in ICUs in North-west France to evaluate ICU physicians’ clinical practice with HFNC. Materials and methods We sent an observational survey to ICU physicians from 34 French ICUs over a 6-month period in 2016–2017. The survey included questions regarding the indications and expected efficiency of HFNC, practical aspects of use (initiation, weaning) and satisfaction. Comparisons between junior and senior ICU physicians were performed using a Fischer exact test. Results Among the 235 ICU physicians contacted, 137 responded (58.3%) all of whom regularly used HFNC. Hypoxemic ARF was considered a good indication for HFNC by all 137, but only 30% expected HFNC success (i.e., avoiding intubation in at least 60% of cases). Among hypoxemic indications, 30% of juniors considered acute pulmonary edema a good indication versus 74% of seniors (p
Published: 2019

35. Inased (inhaled sedation in ICU) trial protocol: a multicentre randomised open-label trial

Author: Bailly, Pierre, primary, Egreteau, Pierre-Yves, additional, Ehrmann, Stephan, additional, Thille, Arnaud W, additional, Guitton, Christophe, additional, Grillet, Guillaume, additional, Reizine, Florian, additional, Huet, Olivier, additional, Jaber, S, additional, Nowak, Emmanuel, additional, and L'her, Erwan, additional
Published: 2021
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36. Die Europäische Union – Regionalisierung in der Globalisierung

Author: Bailly, Pierre, primary
Published: 2009
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37. Thrombotic microangiopathy revealed by a coma

Author: Bailly, Pierre, Chapalain, Xavier, Prat, Gwenaël, Tonnelier, Jean-Marie, and Ben Salem, Douraied
Published: 2019
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38. Pressure-Support Ventilation vs T-Piece During Spontaneous Breathing Trials Before Extubation Among Patients at High Risk of Extubation Failure

Author: Thille, Arnaud W., primary, Coudroy, Rémi, additional, Nay, Mai-Anh, additional, Gacouin, Arnaud, additional, Demoule, Alexandre, additional, Sonneville, Romain, additional, Beloncle, François, additional, Girault, Christophe, additional, Dangers, Laurence, additional, Lautrette, Alexandre, additional, Levrat, Quentin, additional, Rouzé, Anahita, additional, Vivier, Emmanuel, additional, Lascarrou, Jean-Baptiste, additional, Ricard, Jean-Damien, additional, Razazi, Keyvan, additional, Barberet, Guillaume, additional, Lebert, Christine, additional, Ehrmann, Stephan, additional, Massri, Alexandre, additional, Bourenne, Jeremy, additional, Pradel, Gael, additional, Bailly, Pierre, additional, Terzi, Nicolas, additional, Dellamonica, Jean, additional, Lacave, Guillaume, additional, Robert, René, additional, Ragot, Stéphanie, additional, Frat, Jean-Pierre, additional, Boissier, Florence, additional, Chatellier, Delphine, additional, Deletage, Céline, additional, Guignon, Carole, additional, Joly, Florent, additional, Olivry, Morgane, additional, Veinstein, Anne, additional, Benzekri-Lefevre, Dalila, additional, Boulain, Thierry, additional, Muller, Grégoire, additional, Le Tulzo, Yves, additional, Tadié, Jean-Marc, additional, Maamar, Adel, additional, Demiri, Suela, additional, Mayaux, Julien, additional, Decavèle, Maxens, additional, Bouadma, Lila, additional, Dupuis, Claire, additional, Asfar, Pierre, additional, Pierrot, Marc, additional, Béduneau, Gaëtan, additional, Boyer, Déborah, additional, Delmas, Benjamin, additional, Puech, Bérénice, additional, Bachoumas, Konstantinos, additional, Soum, Edouard, additional, Cabasson, Séverin, additional, Hoppe, Marie-Anne, additional, Nseir, Saad, additional, Pouly, Olivier, additional, Bourdin, Gaël, additional, Rosselli, Sylvène, additional, Le Meur, Anthony, additional, Garret, Charlotte, additional, Martin, Maelle, additional, Berquier, Guillaume, additional, Thiagarajah, Abirami, additional, Carteaux, Guillaume, additional, Mekontso-Dessap, Armand, additional, Poidevin, Antoine, additional, Dureau, Anne-Florence, additional, Azais, Marie-Ange, additional, Colin, Gwenhaël, additional, Mercier, Emmanuelle, additional, Morisseau, Marlène, additional, Sabatier, Caroline, additional, Picard, Walter, additional, Gainnier, Marc, additional, Nguyen, Thi-My-Hue, additional, Prat, Gwenaël, additional, Schwebel, Carole, additional, and Buscot, Matthieu, additional
Published: 2020
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39. Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure

Author: Thille, Arnaud, Muller, Grégoire, Gacouin, Arnaud, Coudroy, Rémi, Decavele, Maxens, Sonneville, Romain, Beloncle, Francois, Girault, Christophe, Dangers, Laurence, Lautrette, Alexandre, Cabasson, Séverin, Rouzé, Anahita, Vivier, Emmanuel, Le Meur, Anthony, Ricard, Jean-Damien, Razazi, Keyvan, Barberet, Guillaume, Lebert, Christine, Ehrmann, Stephan, Sabatier, Caroline, Bourenne, Jeremy, Pradel, Gael, Bailly, Pierre, Terzi, Nicolas, Dellamonica, Jean, Lacave, Guillaume, Danin, Pierre-Eric, Nanadoumgar, Hodanou, Gibelin, Aude, Zanre, Lassane, Deye, Nicolas, Demoule, Alexandre, Maamar, Adel, Nay, Mai-Anh, Robert, René, Ragot, Stéphanie, Frat, Jean-Pierre, Réanimation Médicale, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU Pontchaillou [Rennes], Sorbonne Université (SU), Hôpital Ambroise Paré [AP-HP], Service de Réanimation Médicale et de Médecine Hyperbare [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), CHU Rouen, Normandie Université (NU), Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Unité de soins intensifs [Clermont Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier Saint Joseph - Saint Luc [Lyon], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Départemental Les Oudairies, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Laboratoire d'Economie de la Production et de l'Intégration Internationale (LEPII), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF), Service de réanimation médicale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Inserm U1065, Centre Méditerranéen de Médecine Moléculaire, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Réanimation, Hôpital Jean Bernard, CHU de Poitiers, Poitiers, France, Immunologie antivirale systémique et cérébrale, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), BRICHEUX, Genevieve, Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Laboratoire Microorganismes : Génome et Environnement - Clermont Auvergne (LMGE), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Laboratoire d'Économie de la Production et de l'Intégration Internationale (LEPII), Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MP.PRO] Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience
Published: 2019

40. MOESM4 of Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study

Author: Bedet, Alexandre, FranĂ§Oise Tomberli, Prat, Gwenael, Bailly, Pierre, Kouatchet, Achille, Sater Mortaza, Vivier, Emmanuel, Sylvene Rosselli, Lipskaia, Larissa, Carteaux, Guillaume, Razazi, Keyvan, and Dessap, Armand Mekontso
Subjects: sense organs
Abstract: Additional file 4. Changes in biological variables during the second spontaneous breathing trial (SBT), according to the prevalence of weaning-induced cardiac ischemia (WiCI). (PDF 131 kb)
Published: 2019
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41. Chapitre 4. Le contexte socioprofessionnel comme référent de l'évaluation

Author: Ayaichia, A., primary, Bailly, Pierre, additional, Bion, Jean-Yves, additional, Ifrah, Vida Karen, additional, Jolland, Michel, additional, Aubret, Jacques, additional, Figari, Gérard, additional, Kouabénan, Rémi Dongo, additional, and Tarquinio, Cyril, additional
Published: 2001
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42. On the Marc

Author: Bailly, Pierre
Subjects: Fashion designers -- Beliefs, opinions and attitudes, Handbags -- Forecasts and trends, Market trend/market analysis, LVMH Moet Hennessy Louis Vuitton S.A. -- Officials and employees
Abstract: Who says you can't reinvent the wheel? Certainly not Marc Jacobs, the designer who transformed the house of Louis Vuitton into the place for get-'em-while-they're-hot handbags. As the brand turns […]
Published: 2004

43. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial

Author: Frat, Jean-Pierre, primary, Ricard, Jean-Damien, additional, Quenot, Jean-Pierre, additional, Pichon, Nicolas, additional, Demoule, Alexandre, additional, Forel, Jean-Marie, additional, Mira, Jean-Paul, additional, Coudroy, Rémi, additional, Berquier, Guillaume, additional, Voisin, Benoit, additional, Colin, Gwenhaël, additional, Pons, Bertrand, additional, Danin, Pierre Eric, additional, Devaquet, Jérome, additional, Prat, Gwenael, additional, Clere-Jehl, Raphaël, additional, Petitpas, Franck, additional, Vivier, Emmanuel, additional, Razazi, Keyvan, additional, Nay, Mai-Anh, additional, Souday, Vincent, additional, Dellamonica, Jean, additional, Argaud, Laurent, additional, Ehrmann, Stephan, additional, Gibelin, Aude, additional, Girault, Christophe, additional, Andreu, Pascal, additional, Vignon, Philippe, additional, Dangers, Laurence, additional, Ragot, Stéphanie, additional, Thille, Arnaud W, additional, Chatellier, Delphine, additional, Boissier, Florence, additional, Veinstein, Anne, additional, Robert, René, additional, Deletage-Métreau, Céline, additional, Olivry, Morgane, additional, Dahyot-Fizelier, Claire, additional, Dargent, Auguste, additional, Large, Audrey, additional, Begot, Emmanuelle, additional, Mancia, Claire, additional, Decavele, Maxence, additional, Dres, Martin, additional, Lehingue, Samuel, additional, Papazian, Laurent, additional, Paul, Marine, additional, Marin, Nathalie, additional, Le Meur, Matthieu, additional, Laissy, Mohammed, additional, Rouzé, Anaita, additional, Nseir, Saad, additional, Henry-Lagarrigue, Matthieu, additional, Yehia, Aihem, additional, Martino, Frédéric, additional, Cerf, Charles, additional, Bailly, Pierre, additional, Helms, Julie, additional, Putegnat, Jean Baptiste, additional, Mekontso-Dessap, Armand, additional, Boulain, Thierry, additional, Asfar, Pierre, additional, Cabasson, Séverin, additional, Wallet, Florent, additional, Klouche, Kada, additional, and Bellec, Frédéric, additional
Published: 2019
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44. High-flow nasal cannula oxygen therapy alone or with non-invasive ventilation during the weaning period after extubation in ICU: the prospective randomised controlled HIGH-WEAN protocol

Author: Thille, Arnaud W, primary, Muller, Grégoire, additional, Gacouin, Arnaud, additional, Coudroy, Rémi, additional, Demoule, Alexandre, additional, Sonneville, Romain, additional, Beloncle, François, additional, Girault, Christophe, additional, Dangers, Laurence, additional, Lautrette, Alexandre, additional, Cabasson, Séverin, additional, Rouzé, Anahita, additional, Vivier, Emmanuel, additional, Le Meur, Anthony, additional, Ricard, Jean-Damien, additional, Razazi, Keyvan, additional, Barberet, Guillaume, additional, Lebert, Christine, additional, Ehrmann, Stephan, additional, Picard, Walter, additional, Bourenne, Jeremy, additional, Pradel, Gael, additional, Bailly, Pierre, additional, Terzi, Nicolas, additional, Buscot, Matthieu, additional, Lacave, Guillaume, additional, Danin, Pierre-Eric, additional, Nanadoumgar, Hodanou, additional, Gibelin, Aude, additional, Zanre, Lassane, additional, Deye, Nicolas, additional, Ragot, Stéphanie, additional, and Frat, Jean-Pierre, additional
Published: 2018
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