12 results on '"Bailhache E"'
Search Results
2. Metabolism of cholesterol ester of apolipoprotein B100-containing lipoproteins in dogs: evidence for disregarding cholesterol ester transfer
- Author
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Bailhache, E., Briand, F., Nguyen, P., Krempf, M., Magot, T., and Ouguerram, K.
- Published
- 2004
3. Measurement of charged jet suppression in Pb-Pb collisions at root s(NN)=2.76 TeV
- Author
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Abelev, B., Adam, J., Adamova, D., Aggarwal, M. M., Rinela, G. Aglieri, Agnelli, M., Agocs, A. G., Agostinelli, A., Agrawal, N., Ahammed, Z., Altmad, N., Masoodi, A. Ahmad, Ahmed, I., Ahn, S. U., Ahn, S. A., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Aleksandrov, D., Alessandro, B., Alexandre, D., Alici, A., Alkin, A., Alme, J., Alt, T., Altini, V., Altinpinar, S., Altsybeev, I., Prado, C. Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaeuser, H., Arborn, N., Arcelli, S., Armesto, N., Arnaldi, R., Aronsson, T., Arsene, I. C., Arslandok, M., Augustinus, A., Averbeck, R., Awes, T. C., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, E., Bairathi, V., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Ban, J., Baral, R. C., Barbera, R., Barile, F., Barnafoeldi, G. G., Barnby, L. S., Barret, V., Bartke, J., Basie, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Batyunya, B., Batzing, P. C., Baumann, C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Bellwied, R., Belmont Moreno, E., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdniko, Y., Berenyi, D., Berger, M. E., Bergognon, A. A. E., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Bjelogrlic, S., Blanco, F., Blau, D., Blume, C., Bock, F., Boehmer, F. V., Bogdanov, A., Boggild, H., Bogolyubsky, M., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Bornschein, J., Bossu, F., Botje, M., Botta, E., Boettger, S., Braun Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Caffarri, D., Cai, X., Caines, H., Caliva, A., Villar, E. Calvo, Camerini, P., Roman, V. Canoa, Carena, F., Carena, W., Carminati, F., Diaz, A. Casanova, Castellanos, J. Castillo, Casula, E. A. R., Catartescu, V., Cavicchioli, C., Sanchez, C. Ceballos, Cepila, J., Cerello, P., Chang, B., Chapeland, S., Charvet, J. L., Chattopadhyay, S., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Chochula, P., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contin, G., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Cortese, P., Maldonado, I. Cortes, Cosentino, M. R., Costa, F., Crochet, P., Albino, R. Cruz, Cuautle, E., Cunqueiro, L., Dainese, A., Dang, R., Danu, A., Das, D., Das, I., Das, K., Das, S., Dash, A., Dash, S., De, S., Delagrange, H., Deloff, A., Denes, E., D'Erasmo, G., de Barros, G. O. V., De Caro, A., de Cataldo, G., de Cuvelarte, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., de Rooij, R., Corchero, M. A. Diaz, Dietel, T., Divia, R., Di Bari, D., Di Liberto, S., Di Mauro, A., Di Nezza, P., Djuvsland, O., Dobrin, A., Dobrowolski, T., Gimenez, D. Domenicis, Doenigus, B., Dordic, O., Dorheim, S., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Majumdar, A. K. Dutta, Elia, D., Engel, H., Erazmus, B., Erdal, H. A., Eschweiler, D., Espagnon, B., Estienne, M., Esumi, S., Evans, D., Evdokimov, S., Eyyubova, G., Fabris, D., Faivre, J., Falchieri, D., Fantoni, A., Fasel, M., Fehlker, D., Feldkamp, L., Felea, D., Feliciello, A., Feofilov, G., Ferencei, J., Tellez, A. Fernandez, Ferreiro, E. G., Ferretti, A., Festanti, A., Figiel, J., Eigueredo, M. A. S., Filchagin, S., Finogeev, D., Fionda, F. M., Fiore, E. M., Floratos, E., Floris, M., Foertsch, S., Foka, P., Fokin, S., Fragiocomo, E., Francescon, A., Frankenfeld, U., Fuchs, U., Furget, C., Girard, M. Fusco, Gaardhoje, J. J., Gagiardi, M., Galio, M., Gangadharan, D. R., Ganoti, P., Garabatos, C., Garcia Solis, E., Gargiulo, C., Garishvili, I., Gerhard, J., Germain, M., Gheata, A., Gheata, M., Ghidini, B., Ghosh, P., Ghosh, S. K., Gianotti, P., Giubellino, P., Gladysz Dziadus, E., Glaessel, P., Gomez, R., Gonzalez Zamora, P., Gorbunov, S., Goerlich, F., Gotovac, S., Graczykowski, L. K., Grajcarek, R., Grelli, A., Grigoras, A., Grigoras, C., Grigoriev, V., Grigoryan, A., Grigoryan, S., Grinyov, B., Grion, N., Grosse Oetringhaus, J. F., Grossiord, . J. Y., Grosso, R., Guber, F., Guernane, R., Guerzoni, B., Guilbaud, M., Gulbrandsen, K., Gulkanyan, H., Gunji, T., Gupta, A., Gupta, R., Khan, K. H., Haake, R., Haaland, O., Hadjidakis, C., Haiduc, M., Hamagaki, H., Hamar, G., Hanratty, L. D., Hansen, A., Harris, J. W., Hartmann, H., Harton, A., Hatzifotiadou, D., Hayashi, S., Hayrapetyan, A., Heckel, S. T., Heide, M., Helstrup, H., Herghelegiu, A., Corral, G. Herrera, Hess, B. A., Hetland, K. F., Hicks, B., Hippolyte, B., Hladky, J., Hristov, P., Huang, M., Humanic, T. J., Hutter, D., Hwang, D. S., Ianigro, J. C., Ilkiv, I., Inaba, M., Incani, E., Innocenti, G. M., Ionita, C., Ippolitov, M., Irfan, M., Ivanov, M., Ivanov, V., Ivanytsky, O., Jacholkowski, A., Jahnke, C., Jang, H. J., Janik, M. A., Jayarathna, P. H. S. Y., Jena, S., Bustamante, R. T. Jimenez, Jones, P. G., Jung, H., Jusko, A., Kalcher, S., Kalinak, P., Kalweit, A., Kamin, J., Kang, J. H., Kaplin, V., Kar, S., Uysal, A. Karasu, Karavichev, O., Karavicheva, T., Karpechev, E., Kebschull, U., Keidel, R., Ketzer, B., Khan, M. Mohisin, Khan, P., Khan, S. A., Khanzadeev, A., Kharlov, Y., Kileng, B., Kim, B., Kim, D. W., Kim, D. J., Kim, J. S., Kim, M., Kim, S., Kim, T., Krisch, S., Kisel, I., Kiselev, S., Kisiel, A., Kiss, G., Klay, J. L., Klein, J., Klein Boesing, C., Kluge, A., Knichel, M. L., Knospe, A. G., Kobdaj, C., Koehler, M. K., Kollegger, T., Kolojvari, A., Kondratiev, V., Kondratycva, N., Konevskikh, A., Kovalenko, V., Kowalski, M., Kox, S., Meethaleveedu, G. Koyithatta, Kral, J., Kralik, I., Kramer, F., Kracakova, A., Krelina, M., Kretz, M., Krivda, M., Krizek, F., Krus, M., Kryshen, E., Krzewicki, M., Kucera, V., Kucheriaev, Y., Kugathasan, T., Kuhn, C., Kuijer, P. G., Kulakov, I., Kumar, J., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kushpil, S., Kushpil, V., Kweon, M. J., Kwon, Y., de Guevara, P. Ladron, Fernandes, C. Lagana, Lakomov, I., Langoy, R., Lara, C., Lardeux, A., Lattuca, . A., La Pointe, S. L., La Rocca, P., Lea, R., Lee, G. R., Legrand, I., Lehnert, J., Lemmon, R. C., Lenhardt, M., Lenti, V., Leogrande, E., Leoncino, M., Monzon, I. Lcon, Levai, P., Li, S., Lien, J., Lictava, R., Lindal, S., Lindenstruth, V., Lippmann, C., Lisa, M. A., Ljunggren, H. M., Lodato, D. F., Loenne, P. I., Loggins, V. R., Loginov, V., Lohner, D., Loizides, C., Lopez, X., Torres, E. Lopez, X. G., Lu, Luettig, P., Lunardon, M., Luo, J., Luparello, G., Luzzi, C., Gago, A. M., Jacobs, P. M., Ma, R., Maevskaya, A., Mager, M., Mahapatra, D. P., Maire, A., Malaev, M., Cervantes, I. Maldonado, Malinine, L., Mal'Kevich, D., Malzacher, P., Mamonov, A., Manceau, L., Manko, V., Manso, F., Manzari, V., Marchisone, M., Mares, J., Margagliotti, G. V., Margotti, A., Marin, A., Markert, C., Marquard, M., Martashvili, I., Martin, N. A., Martinengo, P., Martinez, M. I., Garcia, G. Martinez, Blanco, J. Martin, Martynov, Y., Mas, A., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Matyja, A., Mayer, C., Mazer, J., Mazumder, R., Mazzoni, M. A., Meddi, Franco, Menchaca Rocha, A., Perez, J. Mercado, Meres, M., Miake, Y., Mikhaylov, K., Milano, L., Milosevic, J., Mischke, A., Mishra, A. N., Miskowiec, D., Mitu, C. M., Mlynarz, J., Mohanty, B., Molnar, L., Zetina, L. Montano, Montes, E., Morando, M., De Godoy, D. A. Moreira, Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muhuri, S., Mukherjee, M., Mueller, H., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Nattrass, C., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nicassio, M., Niculescu, M., Nielsen, B. S., Nikolaev, S., Nikulin, S., Nikulin, V., Nilsen, B. S., Noferini, F., Nomokonov, P., Nooren, G., Nyanin, A., Nyatha, A., Nystrand, J., Oeschler, H., Oh, S., S. K., Oh, Okatan, A., Olah, L., Oleniacz, J., Da Silva, A. C. Oliveira, Onderwaater, J., Oppedisano, C., Velasquez, A. Ortiz, Oskarsson, A., Otwinowski, J., Oyama, K., Pachmayer, Y., Pachr, M., Pagano, P., Paic, G., Painke, F., Pajares, C., Pal, S. K., Palmeri, A., Pant, D., Papikyan, V., Pappalardo, G. S., Park, W. J., Passfeld, A., Patalakha, D. I., Paticchio, V., Paul, B., Pawlak, T., Peitzmann, T., Da Costa, H. Pereira, Filho, E. Pereira De Oliveira, Peresunko, D., Lara, C. E. Perez, Peryt, W., Pesci, A., Pestov, Y., Petracek, V., Petran, M., Petris, M., Petrovici, M., Petta, C., Piano, S., Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Piyarathna, D. B., Ploskon, M., Planinic, M., Pluta, J., Pochybova, S., Podesta Lerma, P. L. M., Poghosyan, M. G., Pohjoisaho, E. H. O., Polichtchouk, B., Poljak, N., Pop, A., Porteboeuf Houssais, S., Porter, J., Pospisil, V., Potukuchi, B., Prasad, S. K., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puddu, G., Pujahari, P., Punin, V., Putschke, J., Qvigstad, H., Rachevski, A., Raha, S., Rak, J., Rakotozafindrabe, A., Ramello, L., Raniwala, R., Raniwala, S., Raesaenen, S. S., Rascanu, B. T., Rathee, D., Rauf, A. W., Razazi, V., Read, K. F., Real, J. S., Redlich, K., Reed, R. J., Rehman, A., Reichelt, P., Reicher, M., Reidt, F., Renfordt, R., Reolon, A. R., Reshetin, A., Rettig, F., Revol, J. P., Reygers, K., Riabov, V., Ricci, R. A., Richert, T., Richter, M., Riedler, P., Riegler, W., Riggi, F., Rivetti, A., Rocco, E., Cahuantzi, M. Rodriguez, Manso, A. Rodriguez, Roed, K., Rogochaya, E., Rohni, S., Rohr, D., Roehrich, D., Romita, R., Ronchetti, F., Ronflette, L., Rosnet, P., Rossegger, S., Rossi, A., Roy, A., Roy, C., Roy, P., Montero, A. J. Rubio, Rui, R., Russo, R., Ryabinkin, E., Ryabov, Y., Rybicki, A., Sadovsky, S., Safarik, K., Sahlmuller, B., Sahoo, R., Sahu, P. K., Saini, J., Salgado, C. A., Salzwedel, J., Sambyal, S., Samsonov, V., Castro, X. Sanchez, Rodriguez, F. J. Sanchez, Sandor, L., Sandoval, A., Sano, M., Santagati, G., Sarkar, D., Scapparone, E., Scarlassara, F., Scharenberg, R. P., Schiaua, C., Schicker, R., Schmidt, C., Schmidt, H. R., Schuchmann, S., Schukraft, J., Schulc, M., Schuster, T., Schutz, Y., Schwarz, K., Schweda, K., Scioli, G., Scomparin, E., Scott, P. A., Scott, R., Segato, G., Seger, J. E., Selyuzhenkov, I., Seo, J., Serradilla, E., Sevcenco, A., Shabetai, A., Shabratova, G., Shahoyan, R., Shangaraev, A., Sharma, N., Sharma, S., Shigaki, K., Shtejer, K., Sibiriak, Y., Siddhanta, S., Siemiarczuk, T., Silvemyr, D., Silvestre, C., Simatovic, G., Singaraju, R., Singh, R., Singha, S., Singhal, V., Sinha, B. C., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Skjerdal, K., Smakal, H., Smirnov, N., Snellings, R. J. M., Sogaard, C., Soltz, R., Song, J., Song, M., Soramel, F., Sorensen, S., Spacek, M., Sputowska, I., Spyropoulou Stassinaki, M., Srivastava, B. K., Stachel, J., Stan, I., Stefanek, G., Steinpreis, M., Stenlund, E., Steyn, G., Stiller, J. H., Stocco, D., Stolpovskiy, M., Strmen, P., Suaide, A. A. P., Vasquez, M. A. Subieta, Sugitate, T., Suire, C., Suleymanov, M., Sultanov, R., Sumbera, M., Susa, T., Symons, T. J. M., de Toledo, A. Szanto, Szarka, I., Szczepankiewicz, A., Szymanski, M., Takahashi, J., Tangaro, M. A., Takaki, J. D. Tapia, Peloni, A. Tarantola, Martinez, A. Tarazona, Tauro, A., Munoz, G. Tejeda, Telesca, A., Terrevoli, C., Ter Minasyan, A., Thaeder, J., Thomas, D., Tieulent, R., Timmins, A. R., Toia, A., Torii, H., Trubnikov, V., Trzaska, W. H., Tsuji, T., Tumkin, A., Turrisi, R., Tveter, T. S., Ulery, J., Ullaland, K., Ulrich, J., Uras, A., Usai, G. L., Vajzer, M., Vala, M., Palomo, L. Valencia, Vallero, S., Vyvre, P. Vande, Vannucci, L., Van Hoorne, J. W., van Leeuwen, M., Vargas, A., Varma, R., Vasileiou, M., Vasiliev, A., Vechernin, V., Veldhoen, M., Venaruzzo, M., Vercellin, E., Limon, S. Vergara, Vernet, R., Verweij, M., Vickovic, L., Viesti, G., Viinikainen, J., Vilakazi, Z., Baillie, O. Villalobos, Vinogradov, A., Vinogradov, L., Vinogradov, Y., Virgili, T., Viyogi, Y. P., Vodopyanov, A., Voelkl, M. A., Voloshin, K., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vranic, D., Vrlakova, J., Vulpescu, B., Vyushin, A., Wagner, B., Wagner, J., Wagner, V., Wang, M., Wang, Y., Watanabe, D., Weber, M., Wessels, J. P., Westerhoff, U., Wiechula, J., Wikne, J., Wilde, M., Wilk, G., Wilkinson, J., Williams, M. C. S., Windelband, B., Winn, M., Xiang, C., Yaldo, C. G., Yamaguchi, Y., Yang, H., Yang, P., Yang, S., Yano, S., Yasnopolskiy, S., Yi, J., Yin, Z., Yoo, I. K., Yushmanov, I., Zaccolo, V., Zach, C., Zaman, A., Zampolli, C., Zaporozhets, S., Zarochentsev, A., Zavada, P., Zaviyalov, N., Zbroszczky, H., Zgura, I. S., Zhalov, M., Zhang, F., Zhang, H., Zhang, X., Zhang, Y., Zhao, C., Zhou, D., Zhou, F., Zhou, Y., Zhu, H., Zhu, J., Zhu, X., Zichichi, A., Zimmermann, A., Zimmermann, M. B., Zinovjev, G., Zoccarato, Y., Zynovyev, M., and Zyzak, M.
- Subjects
jet quenching ,Particle Production ,Large Transverse-Momentum ,heavy ion collisions ,Jets ,nuclear modification factor ,Heavy Ions ,Detector ,jet quenching, heavy ion collisions, nuclear modification factor ,Dependence ,Pp ,Induced Gluon Radiation - Abstract
A measurement of the transverse momentum spectra of jets in Pb-Pb collisions at root s(NN) = 2.76 TeV is reported. Jets are reconstructed from charged particles using the anti-k(T) jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudorapidity vertical bar eta vertical bar < 0.5. The transverse momentum p(T) of charged particles is measured down to 0.15 GeV/c which gives access to the low p(T) fragments of the jet. Jets found in heavy-ion collisions are corrected event-by-event for average background density and on an inclusive basis (via unfolding) for residual background fluctuations and detector effects. A strong suppression of jet production in central events with respect to peripheral events is observed. The suppression is found to be similar to the suppression of charged hadrons, which suggests that substantial energy is radiated at angles larger than the jet resolution parameter R = 0.3 considered in the analysis. The fragmentation bias introduced by selecting jets with a high p(T) leading particle, which rejects jets with a soft fragmentation pattern, has a similar effect on the jet yield for central and peripheral events. The ratio of jet spectra with R = 0.2 and R = 0.3 is found to be similar in Pb-Pb and simulated PYTHIA pp events, indicating no strong broadening of the radial jet structure in the reconstructed jets with R < 0.3.
- Published
- 2014
4. Measurement of charged jet suppression in Pb-Pb collisions at root s(NN)=2.76 TeV
- Author
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Abelev, B. Adam, J. Adamova, D. Aggarwal, M. M. Rinela, G. Aglieri Agnelli, M. Agocs, A. G. Agostinelli, A. and Agrawal, N. Ahammed, Z. Altmad, N. Masoodi, A. Ahmad and Ahmed, I. Ahn, S. U. Ahn, S. A. Aimo, I. Aiola, S. and Ajaz, M. Akindinov, A. Aleksandrov, D. Alessandro, B. and Alexandre, D. Alici, A. Alkin, A. Alme, J. Alt, T. and Altini, V. Altinpinar, S. Altsybeev, I. Prado, C. Alves Garcia Andrei, C. Andronic, A. Anguelov, V. Anielski, J. and Anticic, T. Antinori, F. Antonioli, P. Aphecetche, L. and Appelshaeuser, H. Arborn, N. Arcelli, S. Armesto, N. and Arnaldi, R. Aronsson, T. Arsene, I. C. Arslandok, M. and Augustinus, A. Averbeck, R. Awes, T. C. Azmi, M. D. and Bach, M. Badala, A. Baek, Y. W. Bagnasco, S. Bailhache, E. Bairathi, V. Bala, R. Baldisseri, A. Pedrosa, F. Baltasar Dos Santos Ban, J. Baral, R. C. Barbera, R. and Barile, F. Barnafoeldi, G. G. Barnby, L. S. Barret, V. and Bartke, J. Basie, M. Bastid, N. Basu, S. Bathen, B. and Batigne, G. Batyunya, B. Batzing, P. C. Baumann, C. and Bearden, I. G. Beck, H. Bedda, C. Behera, N. K. Belikov, I. Bellini, F. Bellwied, R. Belmont-Moreno, E. Bencedi, G. Beole, S. Berceanu, I. Bercuci, A. Berdniko, Y. and Berenyi, D. Berger, M. E. Bergognon, A. A. E. Bertens, R. A. and Berzano, D. Betev, L. Bhasin, A. Bhati, A. K. and Bhattacharjee, B. Bhom, J. Bianchi, L. Bianchi, N. and Bianchin, C. Bielcik, J. Bielcikova, J. Bilandzic, A. and Bjelogrlic, S. Blanco, F. Blau, D. Blume, C. Bock, F. and Boehmer, F. V. Bogdanov, A. Boggild, H. Bogolyubsky, M. and Boldizsar, L. Bombara, M. Book, J. Borel, H. and Borissov, A. Bornschein, J. Bossu, F. Botje, M. Botta, E. Boettger, S. Braun-Munzinger, P. Bregant, M. and Breitner, T. Broker, T. A. Browning, T. A. Broz, M. and Bruna, E. Bruno, G. E. Budnikov, D. Buesching, H. and Bufalino, S. Buncic, P. Busch, O. Buthelezi, Z. and Caffarri, D. Cai, X. Caines, H. Caliva, A. Villar, E. Calvo Camerini, P. Roman, V. Canoa Carena, F. Carena, W. and Carminati, F. Diaz, A. Casanova Castellanos, J. Castillo and Casula, E. A. R. Catartescu, V. Cavicchioli, C. Sanchez, C. Ceballos Cepila, J. Cerello, P. Chang, B. Chapeland, S. and Charvet, J. L. Chattopadhyay, S. Chattopadhyay, S. and Cherney, M. Cheshkov, C. Cheynis, B. Barroso, V. Chibante and Chinellato, D. D. Chochula, P. Chojnacki, M. Choudhury, S. Christakoglou, P. Christensen, C. H. Christiansen, P. and Chujo, T. Chung, S. U. Cicalo, C. Cifarelli, L. Cindolo, F. Cleymans, J. Colamaria, F. Colella, D. Collu, A. and Colocci, M. Balbastre, G. Conesa del Valle, Z. Conesa and Connors, M. E. Contin, G. Contreras, J. G. Cormier, T. M. and Morales, Y. Corrales Cortese, P. Maldonado, I. Cortes and Cosentino, M. R. Costa, F. Crochet, P. Albino, R. Cruz and Cuautle, E. Cunqueiro, L. Dainese, A. Dang, R. Danu, A. and Das, D. Das, I. Das, K. Das, S. Dash, A. Dash, S. De, S. Delagrange, H. Deloff, A. Denes, E. and D'Erasmo, G. de Barros, G. O. V. De Caro, A. de Cataldo, G. and de Cuvelarte, J. De Falco, A. De Gruttola, D. De Marco, N. De Pasquale, S. de Rooij, R. Corchero, M. A. Diaz and Dietel, T. Divia, R. Di Bari, D. Di Liberto, S. Di Mauro, A. Di Nezza, P. Djuvsland, O. Dobrin, A. and Dobrowolski, T. Gimenez, D. Domenicis Doenigus, B. Dordic, O. Dorheim, S. Dubey, A. K. Dubla, A. Ducroux, L. and Dupieux, P. Majumdar, A. K. Dutta Elia, D. Engel, H. and Erazmus, B. Erdal, H. A. Eschweiler, D. Espagnon, B. and Estienne, M. Esumi, S. Evans, D. Evdokimov, S. Eyyubova, G. Fabris, D. Faivre, J. Falchieri, D. Fantoni, A. and Fasel, M. Fehlker, D. Feldkamp, L. Felea, D. Feliciello, A. Feofilov, G. Ferencei, J. Tellez, A. Fernandez and Ferreiro, E. G. Ferretti, A. Festanti, A. Figiel, J. and Eigueredo, M. A. S. Filchagin, S. Finogeev, D. Fionda, F. M. and Fiore, E. M. Floratos, E. Floris, M. Foertsch, S. and Foka, P. Fokin, S. Fragiocomo, E. Francescon, A. and Frankenfeld, U. Fuchs, U. Furget, C. Girard, M. Fusco and Gaardhoje, J. J. Gagiardi, M. Galio, M. Gangadharan, D. R. and Ganoti, P. Garabatos, C. Garcia-Solis, E. Gargiulo, C. and Garishvili, I. Gerhard, J. Germain, M. Gheata, A. and Gheata, M. Ghidini, B. Ghosh, P. Ghosh, S. K. Gianotti, P. Giubellino, P. Gladysz-Dziadus, E. Glaessel, P. and Gomez, R. Gonzalez-Zamora, P. Gorbunov, S. Goerlich, F. and Gotovac, S. Graczykowski, L. K. Grajcarek, R. Grelli, A. and Grigoras, A. Grigoras, C. Grigoriev, V. Grigoryan, A. and Grigoryan, S. Grinyov, B. Grion, N. Grosse-Oetringhaus, J. F. Grossiord, . J. -Y. Grosso, R. Guber, F. Guernane, R. and Guerzoni, B. Guilbaud, M. Gulbrandsen, K. Gulkanyan, H. and Gunji, T. Gupta, A. Gupta, R. Khan, K. H. Haake, R. and Haaland, O. Hadjidakis, C. Haiduc, M. Hamagaki, H. and Hamar, G. Hanratty, L. D. Hansen, A. Harris, J. W. and Hartmann, H. Harton, A. Hatzifotiadou, D. Hayashi, S. and Hayrapetyan, A. Heckel, S. T. Heide, M. Helstrup, H. and Herghelegiu, A. Corral, G. Herrera Hess, B. A. Hetland, K. F. Hicks, B. Hippolyte, B. Hladky, J. Hristov, P. and Huang, M. Humanic, T. J. Hutter, D. Hwang, D. S. and Ianigro, J. -C. Ilkiv, I. Inaba, M. Incani, E. and Innocenti, G. M. Ionita, C. Ippolitov, M. Irfan, M. and Ivanov, M. Ivanov, V. Ivanytsky, O. Jacholkowski, A. and Jahnke, C. Jang, H. J. Janik, M. A. Jayarathna, P. H. S. Y. and Jena, S. Bustamante, R. T. Jimenez Jones, P. G. Jung, H. and Jusko, A. Kalcher, S. Kalinak, P. Kalweit, A. Kamin, J. Kang, J. H. Kaplin, V. Kar, S. Uysal, A. Karasu and Karavichev, O. Karavicheva, T. Karpechev, E. Kebschull, U. and Keidel, R. Ketzer, B. Khan, M. Mohisin Khan, P. and Khan, S. A. Khanzadeev, A. Kharlov, Y. Kileng, B. Kim, B. Kim, D. W. Kim, D. J. Kim, J. S. Kim, M. Kim, M. and Kim, S. Kim, T. Krisch, S. Kisel, I. Kiselev, S. and Kisiel, A. Kiss, G. Klay, J. L. Klein, J. Klein-Boesing, C. Kluge, A. Knichel, M. L. Knospe, A. G. Kobdaj, C. and Koehler, M. K. Kollegger, T. Kolojvari, A. Kondratiev, V. and Kondratycva, N. Konevskikh, A. Kovalenko, V. Kowalski, M. Kox, S. Meethaleveedu, G. Koyithatta Kral, J. Kralik, I. Kramer, F. Kracakova, A. Krelina, M. Kretz, M. and Krivda, M. Krizek, F. Krus, M. Kryshen, E. Krzewicki, M. and Kucera, V. Kucheriaev, Y. Kugathasan, T. Kuhn, C. and Kuijer, P. G. Kulakov, I. Kumar, J. Kurashvili, P. and Kurepin, A. Kurepin, A. B. Kuryakin, A. Kushpil, S. and Kushpil, V. Kweon, M. J. Kwon, Y. de Guevara, P. Ladron and Fernandes, C. Lagana Lakomov, I. Langoy, R. Lara, C. and Lardeux, A. Lattuca, . A. La Pointe, S. L. La Rocca, P. and Lea, R. Lee, G. R. Legrand, I. Lehnert, J. Lemmon, R. C. and Lenhardt, M. Lenti, V. Leogrande, E. Leoncino, M. and Monzon, I. Lcon Levai, P. Li, S. Lien, J. Lictava, R. and Lindal, S. Lindenstruth, V. Lippmann, C. Lisa, M. A. and Ljunggren, H. M. Lodato, D. F. Loenne, P. I. Loggins, V. R. and Loginov, V. Lohner, D. Loizides, C. Lopez, X. and Torres, E. Lopez Lu, X. -G. Luettig, P. Lunardon, M. and Luo, J. Luparello, G. Luzzi, C. Gago, A. M. Jacobs, P. M. Ma, R. Maevskaya, A. Mager, M. Mahapatra, D. P. and Maire, A. Malaev, M. Cervantes, I. Maldonado Malinine, L. and Mal'Kevich, D. Malzacher, P. Mamonov, A. Manceau, L. and Manko, V. Manso, F. Manzari, V. Marchisone, M. Mares, J. and Margagliotti, G. V. Margotti, A. Marin, A. Markert, C. and Marquard, M. Martashvili, I. Martin, N. A. Martinengo, P. Martinez, M. I. Garcia, G. Martinez Blanco, J. Martin and Martynov, Y. Mas, A. Masciocchi, S. Masera, M. Masoni, A. Massacrier, L. Mastroserio, A. Matyja, A. Mayer, C. and Mazer, J. Mazumder, R. Mazzoni, M. A. Meddi, F. and Menchaca-Rocha, A. Perez, J. Mercado Meres, M. Miake, Y. and Mikhaylov, K. Milano, L. Milosevic, J. Mischke, A. and Mishra, A. N. Miskowiec, D. Mitu, C. M. Mlynarz, J. and Mohanty, B. Molnar, L. Zetina, L. Montano Montes, E. and Morando, M. De Godoy, D. A. Moreira Moretto, S. Morreale, A. and Morsch, A. Muccifora, V. Mudnic, E. Muhuri, S. and Mukherjee, M. Mueller, H. Munhoz, M. G. Murray, S. Musa, L. Musinsky, J. Nandi, B. K. Nania, R. Nappi, E. and Nattrass, C. Nayak, T. K. Nazarenko, S. Nedosekin, A. and Nicassio, M. Niculescu, M. Nielsen, B. S. Nikolaev, S. and Nikulin, S. Nikulin, V. Nilsen, B. S. Noferini, F. and Nomokonov, P. Nooren, G. Nyanin, A. Nyatha, A. Nystrand, J. Oeschler, H. Oh, S. Oh, S. K. Okatan, A. Olah, L. and Oleniacz, J. Da Silva, A. C. Oliveira Onderwaater, J. and Oppedisano, C. Velasquez, A. Ortiz Oskarsson, A. Otwinowski, J. Oyama, K. Pachmayer, Y. Pachr, M. Pagano, P. and Paic, G. Painke, F. Pajares, C. Pal, S. K. Palmeri, A. and Pant, D. Papikyan, V. Pappalardo, G. S. Park, W. J. and Passfeld, A. Patalakha, D. I. Paticchio, V. Paul, B. and Pawlak, T. Peitzmann, T. Da Costa, H. Pereira Filho, E. Pereira De Oliveira Peresunko, D. Lara, C. E. Perez Peryt, W. Pesci, A. Pestov, Y. Petracek, V. Petran, M. and Petris, M. Petrovici, M. Petta, C. Piano, S. Pikna, M. and Pillot, P. Pinazza, O. Pinsky, L. Piyarathna, D. B. and Ploskon, M. Planinic, M. Pluta, J. Pochybova, S. and Podesta-Lerma, P. L. M. Poghosyan, M. G. Pohjoisaho, E. H. O. and Polichtchouk, B. Poljak, N. Pop, A. Porteboeuf-Houssais, S. Porter, J. Pospisil, V. Potukuchi, B. Prasad, S. K. and Preghenella, R. Prino, F. Pruneau, C. A. Pshenichnov, I. and Puddu, G. Pujahari, P. Punin, V. Putschke, J. and Qvigstad, H. Rachevski, A. Raha, S. Rak, J. and Rakotozafindrabe, A. Ramello, L. Raniwala, R. Raniwala, S. and Raesaenen, S. S. Rascanu, B. T. Rathee, D. Rauf, A. W. and Razazi, V. Read, K. F. Real, J. S. Redlich, K. Reed, R. J. Rehman, A. Reichelt, P. Reicher, M. Reidt, F. and Renfordt, R. Reolon, A. R. Reshetin, A. Rettig, F. and Revol, J. -P. Reygers, K. Riabov, V. Ricci, R. A. and Richert, T. Richter, M. Riedler, P. Riegler, W. Riggi, F. Rivetti, A. Rocco, E. Cahuantzi, M. Rodriguez Manso, A. Rodriguez Roed, K. Rogochaya, E. Rohni, S. Rohr, D. and Roehrich, D. Romita, R. Ronchetti, F. Ronflette, L. and Rosnet, P. Rossegger, S. Rossi, A. Roy, A. Roy, C. and Roy, P. Montero, A. J. Rubio Rui, R. Russo, R. and Ryabinkin, E. Ryabov, Y. Rybicki, A. Sadovsky, S. and Safarik, K. Sahlmuller, B. Sahoo, R. Sahu, P. K. Saini, J. Salgado, C. A. Salzwedel, J. Sambyal, S. Samsonov, V. and Castro, X. Sanchez Rodriguez, F. J. Sanchez Sandor, L. and Sandoval, A. Sano, M. Santagati, G. Sarkar, D. and Scapparone, E. Scarlassara, F. Scharenberg, R. P. Schiaua, C. Schicker, R. Schmidt, C. Schmidt, H. R. Schuchmann, S. Schukraft, J. Schulc, M. Schuster, T. Schutz, Y. and Schwarz, K. Schweda, K. Scioli, G. Scomparin, E. Scott, P. A. Scott, R. Segato, G. Seger, J. E. Selyuzhenkov, I. and Seo, J. Serradilla, E. Sevcenco, A. Shabetai, A. and Shabratova, G. Shahoyan, R. Shangaraev, A. Sharma, N. and Sharma, S. Shigaki, K. Shtejer, K. Sibiriak, Y. and Siddhanta, S. Siemiarczuk, T. Silvemyr, D. Silvestre, C. and Simatovic, G. Singaraju, R. Singh, R. Singha, S. and Singhal, V. Sinha, B. C. Sinha, T. Sitar, B. Sitta, M. and Skaali, T. B. Skjerdal, K. Smakal, H. Smirnov, N. and Snellings, R. J. M. Sogaard, C. Soltz, R. Song, J. Song, M. Soramel, F. Sorensen, S. Spacek, M. Sputowska, I. and Spyropoulou-Stassinaki, M. Srivastava, B. K. Stachel, J. and Stan, I. Stefanek, G. Steinpreis, M. Stenlund, E. Steyn, G. Stiller, J. H. Stocco, D. Stolpovskiy, M. Strmen, P. and Suaide, A. A. P. Vasquez, M. A. Subieta Sugitate, T. and Suire, C. Suleymanov, M. Sultanov, R. Sumbera, M. Susa, T. Symons, T. J. M. de Toledo, A. Szanto Szarka, I. and Szczepankiewicz, A. Szymanski, M. Takahashi, J. Tangaro, M. A. Takaki, J. D. Tapia Peloni, A. Tarantola Martinez, A. Tarazona Tauro, A. Munoz, G. Tejeda Telesca, A. and Terrevoli, C. Ter Minasyan, A. Thaeder, J. Thomas, D. and Tieulent, R. Timmins, A. R. Toia, A. Torii, H. and Trubnikov, V. Trzaska, W. H. Tsuji, T. Tumkin, A. and Turrisi, R. Tveter, T. S. Ulery, J. Ullaland, K. Ulrich, J. Uras, A. Usai, G. L. Vajzer, M. Vala, M. Palomo, L. Valencia Vallero, S. Vyvre, P. Vande Vannucci, L. Van Hoorne, J. W. van Leeuwen, M. Vargas, A. Varma, R. and Vasileiou, M. Vasiliev, A. Vechernin, V. Veldhoen, M. and Venaruzzo, M. Vercellin, E. Limon, S. Vergara Vernet, R. and Verweij, M. Vickovic, L. Viesti, G. Viinikainen, J. and Vilakazi, Z. Baillie, O. Villalobos Vinogradov, A. and Vinogradov, L. Vinogradov, Y. Virgili, T. Viyogi, Y. P. and Vodopyanov, A. Voelkl, M. A. Voloshin, K. Voloshin, S. A. and Volpe, G. von Haller, B. Vorobyev, I. Vranic, D. and Vrlakova, J. Vulpescu, B. Vyushin, A. Wagner, B. Wagner, J. Wagner, V. Wang, M. Wang, Y. Watanabe, D. Weber, M. Wessels, J. P. Westerhoff, U. Wiechula, J. Wikne, J. and Wilde, M. Wilk, G. Wilkinson, J. Williams, M. C. S. and Windelband, B. Winn, M. Xiang, C. Yaldo, C. G. and Yamaguchi, Y. Yang, H. Yang, P. Yang, S. Yano, S. and Yasnopolskiy, S. Yi, J. Yin, Z. Yoo, I-K. Yushmanov, I. and Zaccolo, V. Zach, C. Zaman, A. Zampolli, C. and Zaporozhets, S. Zarochentsev, A. Zavada, P. Zaviyalov, N. and Zbroszczky, H. Zgura, I. S. Zhalov, M. Zhang, F. and Zhang, H. Zhang, X. Zhang, Y. Zhao, C. Zhou, D. and Zhou, F. Zhou, Y. Zhu, H. Zhu, J. Zhu, J. Zhu, X. and Zichichi, A. Zimmermann, A. Zimmermann, M. B. Zinovjev, G. Zoccarato, Y. Zynovyev, M. Zyzak, M.
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Astrophysics::High Energy Astrophysical Phenomena ,High Energy Physics::Experiment ,Nuclear Experiment - Abstract
A measurement of the transverse momentum spectra of jets in Pb-Pb collisions at root s(NN) = 2.76 TeV is reported. Jets are reconstructed from charged particles using the anti-k(T) jet algorithm with jet resolution parameters R of 0.2 and 0.3 in pseudorapidity vertical bar eta vertical bar < 0.5. The transverse momentum p(T) of charged particles is measured down to 0.15 GeV/c which gives access to the low p(T) fragments of the jet. Jets found in heavy-ion collisions are corrected event-by-event for average background density and on an inclusive basis (via unfolding) for residual background fluctuations and detector effects. A strong suppression of jet production in central events with respect to peripheral events is observed. The suppression is found to be similar to the suppression of charged hadrons, which suggests that substantial energy is radiated at angles larger than the jet resolution parameter R = 0.3 considered in the analysis. The fragmentation bias introduced by selecting jets with a high p(T) leading particle, which rejects jets with a soft fragmentation pattern, has a similar effect on the jet yield for central and peripheral events. The ratio of jet spectra with R = 0.2 and R = 0.3 is found to be similar in Pb-Pb and simulated PYTHIA pp events, indicating no strong broadening of the radial jet structure in the reconstructed jets with R < 0.3.
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- 2014
5. Metabolism of high density lipoprotein apolipoprotein A‐I and cholesteryl ester in insulin resistant dog: a stable isotope study
- Author
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Briand, F., primary, Bailhache, E., additional, Nguyen, P., additional, Krempf, M., additional, Magot, T., additional, and Ouguerram, K., additional
- Published
- 2006
- Full Text
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6. Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity
- Author
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Gayet, C., primary, Bailhache, E., additional, Dumon, H., additional, Martin, L., additional, Siliart, B., additional, and Nguyen, P., additional
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- 2004
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7. An insulin‐resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique
- Author
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Bailhache, E., primary, Ouguerram, K., additional, Gayet, C., additional, Krempf, M., additional, Siliart, B., additional, Magot, T., additional, and Nguyen, P., additional
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- 2003
- Full Text
- View/download PDF
8. Insulin resistance and changes in plasma concentration of TNF α, IGF1, and NEFA in dogs during weight gain and obesity.
- Author
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Gayet, C., Bailhache, E., Dumon, H., Martin, L., Siliart, B., and Nguyen, P.
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BLOOD plasma , *HORMONES , *HYPOGLYCEMIC agents , *INSULIN , *PANCREATIC secretions , *NUTRITION disorders - Abstract
Obesity-induced insulin resistance (IR) is a common problem in humans as well as domestic dogs. It is well-known that this syndrome is associated with many modifications but it is still unclear if the changes are alterations or adaptations. The purpose of this study was to develop obesity-induced IR in dogs, through a long-term overfeeding period, and to explore hormonal and metabolic disturbances associated with the development of this syndrome. Dogs were overfed for 7 months. Body weight increased by 43 ± 5%, and insulin sensitivity decreased by 44 ± 5%. Plasma insulin-like growth factor 1 (IGF1), tumour necrosis factor alpha (TNF α), and non-esterified fatty acids (NEFA) concentrations progressively increased during the overfeeding period (IGF1: 111 ± 13 to 266 ± 32 ng/ml, p < 0.001; TNF α: 5 ± 5 to 134 ± 41 pg/ml; NEFA: 0.974 ± 0.094 to 1.590 ± 0.127 mmol/l, p < 0.05). These metabolic and hormonal impairments are associated with IR, in obese dogs, and could explain, at least in part, the outbreak of this syndrome. [ABSTRACT FROM AUTHOR]
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- 2004
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9. The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes.
- Author
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Briand F, Bailhache E, Andre A, Magot T, Krempf M, Nguyen P, and Ouguerram K
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- Animals, Blood Glucose metabolism, Cholesterol blood, Diet, Dogs, Gas Chromatography-Mass Spectrometry, Insulin blood, Kinetics, Leucine metabolism, Lipoproteins, LDL blood, Lipoproteins, VLDL blood, Obesity blood, Apolipoprotein B-100 metabolism, Energy Intake physiology, Insulin Resistance physiology, Obesity metabolism
- Abstract
The hyperenergetic-fed beagle dog model of obesity-associated insulin resistance has previously demonstrated lipoprotein abnormalities similar to those of obese insulin-resistant humans. The aim of this study was to check, in the insulin-resistant dog, the mechanism leading to abnormalities in the mass of apolipoprotein B-100 (apo B-100) containing lipoproteins. Six healthy male beagle dogs were overfed with a high-fat diet for 28 +/- 2.5 weeks. Obesity was associated with insulin resistance as assessed by the euglycemic hyperinsulinemic clamp technique. The kinetics of very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) apo B-100 were recorded in dogs, at healthy and insulin-resistant states, using a primed constant infusion of [5,5,5-D(3)]leucine. Isotopic enrichment was measured by gas chromatography-mass spectrometry (GC-MS). A multicompartmental model was used for the analysis of tracer kinetics data. Apolipoprotein B-100 concentration was higher in VLDL (2.8-fold, P < .05) but lower in LDL (2-fold, P < .05) in the insulin-resistant compared to the healthy state. Kinetic analysis showed a higher VLDL apo B-100 production (1.7-fold, P < .05). The fractional catabolic rate of VLDL did not change significantly, but the lipolysis was decreased significantly (3-fold, P < .05). The lower LDL apo B-100 level in insulin-resistant dogs was explained by a higher LDL fractional catabolic rate (2.5-fold, P < .05). The mechanisms leading to hypertriglyceridemia (higher production rate and lower lipolysis of VLDL) in insulin-resistant dogs were similar to those described in the insulin-resistant humans.
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- 2008
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10. Gastric emptying rate is inversely related to body weight in dog breeds of different sizes.
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Bourreau J, Hernot D, Bailhache E, Weber M, Ferchaud V, Biourge V, Martin L, Dumon H, and Nguyen P
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- Animals, Breath Tests, Caprylates metabolism, Dogs, Female, Gas Chromatography-Mass Spectrometry, Male, Species Specificity, Body Weight, Gastric Emptying physiology
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- 2004
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11. Selective uptake of high density lipoproteins cholesteryl ester in the dog, a species lacking in cholesteryl ester transfer protein activity; An in vivo approach using stable isotopes.
- Author
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Ouguerram K, Nguyen P, Krempf M, Pouteau E, Briand F, Bailhache E, and Magot T
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- Animals, Cholesterol chemistry, Cholesterol metabolism, Cholesterol Esters metabolism, Dogs, Humans, Kinetics, Lipoproteins, HDL metabolism, Mass Spectrometry, Models, Biological, Models, Chemical, Phosphatidylcholine-Sterol O-Acyltransferase metabolism, Phosphatidylcholines chemistry, Species Specificity, Time Factors, Cholesterol Esters chemistry, Lipoproteins, HDL chemistry
- Abstract
Amongst the processes involved in the reverse cholesterol transport (RCT) from organs to liver, including high density lipoproteins-apolipoprotein AI (HDL-apoAI) dependent tissue uptake and cholesteryl ester transfer protein (CETP)-mediated transfers, the selective uptake of cholesteryl ester (CE) is of increasing interest through its antiatherogenic role. The purpose of this report is to develop a simple protocol allowing study of this process in an animal model with easier quantification of CE selective uptake. The dog was chosen essentially because this animal has a low CETP activity and an appropriate size to conduce a kinetic study. Tracer kinetics were performed to estimate in vivo the contributions of the pathways involved in HDL-CE turnover in dogs. Stable isotopes, 13C-acetate and D3-leucine as labeled precursors of CE and apoAI, were infused to fasting dogs. Isotopic enrichments were monitored in plasma unesterified cholesterol and in HDL-CE and apoAI by mass spectrometry. Kinetics were analyzed using compartmental modeling. Results concerned the measurement of the activity of cholesterol esterification (0.13+/-0.032 h(-1)), rate of HDL-apoAI catabolism (0.024+/-0.012 h(-1)), HDL-CE turnover (0.062+/-0.010 h(-1)) and CE selective uptake (0.038+/-0.014 h(-1)). Our results show that CE in dogs is mainly eliminated by selective uptake of HDL-CE (60% of HDL-CE turnover), unlike in other species studied by similar methods in our laboratory. This study shows that among species used to analyze cholesterol metabolism, the dog appears to be the animal in whom HDL-CE selective uptake represents the largest part of HDL-CE turnover.
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- 2004
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12. Lipoproteins abnormalities in obese insulin-resistant dogs.
- Author
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Bailhache E, Nguyen P, Krempf M, Siliart B, Magot T, and Ouguerram K
- Subjects
- Animals, Blood Glucose metabolism, Body Weight physiology, Chromatography, High Pressure Liquid, Diet, Dogs, Glucose Clamp Technique, Hyperinsulinism blood, Insulin blood, Lipoproteins blood, Lipoproteins, HDL blood, Lipoproteins, VLDL blood, Male, Obesity blood, Triglycerides blood, Insulin Resistance physiology, Lipoproteins metabolism, Obesity metabolism
- Abstract
Many studies have shown that obesity and low insulin sensitivity are associated with lipoprotein abnormalities, which are risk factors for coronary heart disease. The effects of insulin resistance on lipoprotein metabolism were investigated in hyperenergetic-fed beagle dogs, a new model of insulin resistance. Insulin resistance was assessed by the 3-hour euglycemic-hyperinsulinemic glucose clamp technique. Lipoproteins were separated by fast-protein liquid chromatography (FPLC) and lipid composition of the different lipoproteins was determined by enzymatic methods. Hyperenergetic diet was associated with a 43% +/- 5% increase in dog body weight and a reduction in insulin-mediated glucose uptake (28 +/- 3 to 16 +/- 1 mg. kg(-1). min(-1), P <.05). Low insulin sensitivity associated with obesity was related to an increase in plasma triglyceride (TG) through an increase in very-low-density lipoprotein (VLDL)-TG (0.071 +/- 0.020 v 0.382 +/- 0.242 mmol/L, P <.05) and high-density lipoprotein (HDL)-TG (0.025 +/- 0.012 v 0.242 +/- 0.143 mmol/L, P <.05). Other lipid abnormalities common in insulin resistant humans were also found: lower plasma HDL-cholesterol (4.690 +/- 0.151 v 3.937 +/- 0.141 mmol/L, P <.05) and higher plasma nonesterified fatty acids (NEFA) (0.974 +/- 0.094 v 1.590 +/- 0.127 mmol/L, P <.05) levels. These data show that this model of the insulin-resistant obese dog could be useful in studying insulin resistance-associated dyslipidemia., (Copyright 2003 Elsevier Inc. All rights reserved.)
- Published
- 2003
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