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Your search keyword '"Baik, Tae Gon"' showing total 36 results
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36 results on '"Baik, Tae Gon"'

4. YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2

Author

Li, Zheng-Yi, primary, Chung, Yoon Hee, additional, Shin, Eun-Joo, additional, Dang, Duy-Khanh, additional, Jeong, Ji Hoon, additional, Ko, Sung Kwon, additional, Nah, Seung-Yeol, additional, Baik, Tae Gon, additional, Jhoo, Jin Hyeong, additional, Ong, Wei-Yi, additional, Nabeshima, Toshitaka, additional, and Kim, Hyoung-Chun, additional

Published
2017
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5. YY-1224, a terpene trilactone-strengthened Ginkgo biloba, attenuates neurodegenerative changes induced by β-amyloid (1-42) or double transgenic overexpression of APP and PS1 via inhibition of cyclooxygenase-2.

Author

Zheng-Yi Li, Yoon Hee Chung, Eun-Joo Shin, Duy-Khanh Dang, Ji Hoon Jeong, Sung Kwon Ko, Seung-Yeol Nah, Tae Gon Baik, Jin Hyeong Jhoo, Wei-Yi Ong, Toshitaka Nabeshima, Hyoung-Chun Kim, Li, Zheng-Yi, Chung, Yoon Hee, Shin, Eun-Joo, Dang, Duy-Khanh, Jeong, Ji Hoon, Ko, Sung Kwon, Nah, Seung-Yeol, and Baik, Tae Gon

Subjects
TERPENES, AMYLOID, CYCLOOXYGENASE 2, GENE expression, PEROXISOMES, THERAPEUTIC use of plant extracts, REACTIVE oxygen species, ALZHEIMER'S disease, ANIMAL experimentation, GINKGO, MEMBRANE proteins, MICE, NEURODEGENERATION, ORGANIC compounds, OXIDOREDUCTASES, PEPTIDES, PROTEIN precursors, PLANT extracts, PREVENTION, THERAPEUTICS
Abstract

Background: Ginkgo biloba has been reported to possess free radical-scavenging antioxidant activity and anti-inflammatory properties. In our pilot study, YY-1224, a terpene trilactone-strengthened extract of G. biloba, showed anti-inflammatory, neurotrophic, and antioxidant effects.Results: We investigated the pharmacological potential of YY-1224 in β-amyloid (Aβ) (1-42)-induced memory impairment using cyclooxygenase-2 (COX-2) knockout (-/-) and APPswe/PS1dE9 transgenic (APP/PS1 Tg) mice. Repeated treatment with YY-1224 significantly attenuated Aβ (1-42)-induced memory impairment in COX-2 (+/+) mice, but not in COX-2 (-/-) mice. YY-1224 significantly attenuated Aβ (1-42)-induced upregulation of platelet-activating factor (PAF) receptor gene expression, reactive oxygen species, and pro-inflammatory factors. In addition, YY-1224 significantly inhibited Aβ (1-42)-induced downregulation of PAF-acetylhydrolase-1 (PAF-AH-1) and peroxisome proliferator-activated receptor γ (PPARγ) gene expression. These changes were more pronounced in COX-2 (+/+) mice than in COX-2 (-/-) mice. YY-1224 significantly attenuated learning impairment, Aβ deposition, and pro-inflammatory microglial activation in APP/PS1 Tg mice, whereas it significantly enhanced PAF-AH and PPARγ expression. A preferential COX-2 inhibitor, meloxicam, did not affect the pharmacological activity by YY-1224, suggesting that the COX-2 gene is a critical mediator of the neuroprotective effects of YY-1224. The protective activity of YY-1224 appeared to be more efficacious than a standard G. biloba extract (Gb) against Aβ insult.Conclusions: Our results suggest that the protective effects of YY-1224 against Aβ toxicity may be associated with its PAF antagonistic- and PPARγ agonistic-potential as well as inhibition of the Aβ-mediated pro-inflammatory switch of microglia phenotypes through suppression of COX-2 expression. [ABSTRACT FROM AUTHOR]

Published
2017
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6. A diastereoselective metal-catalyzed (2+2) cycloaddiation of bis-enones

Author

Baik, Tae-Gon, Luis, Ana Liza, Wang, Long-Cheng, and Krische, Michael J.

Subjects
Carbonyl compounds -- Research, Ring formation (Chemistry) -- Research, Chemistry
Abstract

The diastereoselective metal-catalyzed (2+2) cycloaddition of bis-enones is described.

Published
2001

7. Diastereselective cobalt-catalyzed aldol and Michael cycloreductions

Author

Baik, Tae-Gon, Luis, Ana Liza, Wang, Long-Cheng, and Krische, Michael J.

Subjects
Chemical reactions -- Observations, Cobalt -- Usage, Chemistry
Abstract

The first examples of catalytic aldol and Michael cycloreductions are reported, showing high rates of syn- and anti-diastereoselectivity.

Published
2001

8. Palladium-catlyazed carbocyclization/silastannylation and distannylation of bis

Author

Kang, Suk-Ku, Baik, Tae-Gon, Kulak, Alexander N., Ha, Young-Hwan, Lim, Yoongho, and Park, Joongmin

Subjects
Ring formation (Chemistry) -- Observations, Transition metals -- Research, Chemistry
Abstract

Bis(allenes) were studied to determine the palladium-catalyzed carbocyclization/silastannylation and distannylation.

Published
2000

9. Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Author

Takeuchi, Craig S., primary, Kim, Byung Gyu, additional, Blazey, Charles M., additional, Ma, Sunghoon, additional, Johnson, Henry W. B., additional, Anand, Neel K., additional, Arcalas, Arlyn, additional, Baik, Tae Gon, additional, Buhr, Chris A., additional, Cannoy, Jonah, additional, Epshteyn, Sergey, additional, Joshi, Anagha, additional, Lara, Katherine, additional, Lee, Matthew S., additional, Wang, Longcheng, additional, Leahy, James W., additional, Nuss, John M., additional, Aay, Naing, additional, Aoyama, Ron, additional, Foster, Paul, additional, Lee, Jae, additional, Lehoux, Isabelle, additional, Munagala, Narsimha, additional, Plonowski, Arthur, additional, Rajan, Sharmila, additional, Woolfrey, John, additional, Yamaguchi, Kyoko, additional, Lamb, Peter, additional, and Miller, Nicole, additional

Published
2013
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29. Discovery of a Novel Classof Highly Potent, Selective,ATP-Competitive, and Orally Bioavailable Inhibitors of the MammalianTarget of Rapamycin (mTOR).

Author

Takeuchi, Craig S., Kim, Byung Gyu, Blazey, Charles M., Ma, Sunghoon, Johnson, Henry W. B., Anand, Neel K., Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A., Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S., Wang, Longcheng, Leahy, James W., Nuss, John M., Aay, Naing, Aoyama, Ron, and Foster, Paul

Published
2013
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