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291 results on '"Baidya, S."'

15. TOLL-LIKE RECEPTOR-4 (TLR4) GENE POLYMORPHISM IN HARINGHATA BLACK CHICKEN BREED

Author

Saikhom R, Sahoo A.K., Taraphder S, Pan S, Sarkar U., Ghosh P. R., Bhattacharya D., and Baidya S

Subjects
Haringhata Black Chicken, TLR4 Gene, Polymorphism, PCR-SSCP, Veterinary medicine, SF600-1100
Abstract

The experiment was conducted on Haringhata Black Chicken breed to investigate the polymorphism of exon-2 of Toll-Like Receptor-4 gene. Genomic DNA extracted from 82 birds was used for Polymerase Chain Reaction (PCR). Amplified polymerase chain reaction (PCR) product (248bp) of exon-2 of TLR4 gene revealed two types of SSCP banding pattern arbitrarily assigned as EF and FF genotypes on 10 percent polyacrylamide gel. The genotype frequencies were found to be 0.634 for EF and 0.366 for FF genotype with respect to exon-2 of TLR4 gene. The frequencies of E and F alleles were estimated as 0.317 and 0.683, respectively. The calculated Chi square value revealed that the population was not in Hardy Weinberg Equilibrium with respect to TLR4 gene in Haringhata Black Chicken.

Published
2018

17. PROLACTIN GENE POLYMORPHISM IN HARINGHATA BLACK CHICKEN BREED

Author

Saikhom R, Sahoo A.K., Taraphder S, Pan S, Sarkar U, Ghosh P.R, Bhattacharya D, and Baidya S

Subjects
Haringhata Black Chicken, Prolactin Gene, Polymorphism, PCR-SSCP, Veterinary medicine, SF600-1100
Abstract

PCR-SSCP analysis was carried out to investigate the polymorphism of prolactin gene in Haringhata Black chicken. The amplified fragment (497 bp) of promoter region of prolactin gene revealed three types of SSCP banding pattern arbitrarily assigned as CC, CD and DD genotypes on 10 percent polyacrylamide gel. The heterozygous CD genotypes showed presence of maximum five bands while rest two homozygous genotypes CC and DD showed three and two bands, respectively. In the present study, genotype frequencies were found to be 0.622 for CC, 0.341 for CD and 0.037 for DD genotype with respect to promoter region of prolactin gene. The frequencies of C and D alleles were estimated as 0.793 and 0.207, respectively. The calculated Chi square value revealed that the population was in Hardy Weinberg Equilibrium with respect to promoter region of prolactin gene in Haringhata Black Chicken.

Published
2017

33. First report of target spot on tomato caused by Corynespora cassiicola in Nepal.

Author

Khadka, R. B., Bhandari, R., Rimal, A., Gaire, A., Adhikari, S., Bhandari, S., Manandhar, S., and Baidya, S.

Subjects
CORYNESPORA, TOMATOES, PLANT inoculation, PLANT diseases, GENE libraries
Abstract

Typical necrotic spots with characteristic target spot symptoms appeared in leaves and stems three days after inoculation and plants collapsed within two-three days after symptom development, but no such symptoms developed in non-inoculated plants during the 14 days the plants were monitored post-inoculation (Figure 3). Keywords: Emerging disease; Nepal; Vegetable disease EN Emerging disease Nepal Vegetable disease 1 3 3 09/28/23 20230701 NES 230701 Tomato ( I Solanum lycopersicum i ) is one of the most important vegetable crops in Nepal and is grown in high tunnels and open fields (Rawal et al., [4]). [Extracted from the article]

Published
2023
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36. Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome

Author

Kjeldsen-Kragh, J, Fergusson, DA, Kjaer, M, Lieberman, L, Greinacher, A, Murphy, MF, Bussel, J, Bakchoul, T, Corke, S, Bertrand, G, Oepkes, D, Baker, JM, Hume, H, Massey, E, Kaplan, C, Arnold, DM, Baidya, S, Ryan, G, Savoia, HF, Landry, D, Shehata, N, Kjeldsen-Kragh, J, Fergusson, DA, Kjaer, M, Lieberman, L, Greinacher, A, Murphy, MF, Bussel, J, Bakchoul, T, Corke, S, Bertrand, G, Oepkes, D, Baker, JM, Hume, H, Massey, E, Kaplan, C, Arnold, DM, Baidya, S, Ryan, G, Savoia, HF, Landry, D, and Shehata, N

Abstract

The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3*01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic literature search identified 4 prospective and 8 retrospective studies. Data were combined across studies to estimate pooled odds ratios (ORs) and the associated 95% confidence intervals (CIs). The population represented by the prospective studies was more than 150 000. In the prospective studies, there were 64 severely thrombocytopenic newborns (platelet count <50 × 109/L) of whom 3 had intracranial hemorrhage. The mothers of all 64 children were HLA-DRB3*01:01+. The number of severely thrombocytopenic children born of HPA-1a-alloimmunized women in the retrospective studies was 214; 205 of whom were born of HLA-DRB3*01:01+ women. For HLA-DRB3*01:01- women, the OR (95% CI) for alloimmunization was 0.05 (0.00-0.60), and for severe neonatal thrombocytopenia 0.08 (0.02-0.37). This meta-analysis demonstrates that the risk of alloimmunization and of having a child with severe thrombocytopenia are both very low for HPA-1a- women who are HLA-DRB3*01:01-.

Published
2020

44. Climate Change-Resilient Rice Production Technology: A High Yielding, Water Efficient and Remunerative Option for South Asian Farmers

Author

Biswas, Benukar, primary, Patra, S R, additional, Timsina, J, additional, De, D, additional, Mishra, B, additional, Chakraborti, R, additional, Patra, A, additional, Mahato, B, additional, Banerjee, P, additional, Ghosh, P K, additional, Mukherjee, J, additional, Das, S, additional, Sarkar, S, additional, Adhikary, S, additional, Mondal, M, additional, Kanthal, S, additional, Baidya, S, additional, Banerjee, S, additional, Mandal, B, additional, and Ray, B R, additional

Published
2019
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46. Postnatal intervention for the treatment of FNAIT: a systematic review

Author

Baker, J.M., Shehata, N., Bussel, J., Murphy, M.F., Greinacher, A., Bakchoul, T., Massey, E., Lieberman, L., Landry, D., Tanael, S., Arnold, D.M., Baidya, S., Bertrand, G., Kjaer, M., Kaplan, C., Kjeldsen-Kragh, J., Oepkes, D., Savoia, H., Ryan, G., Hume, H., Allard, S., Bianco, C., Callum, J., Compernolle, V., Fergusson, D., Fung, M., Nahirniak, S., Pavenski, K., Pink, J., Ponnampalam, A., Rebulla, P., So-Osman, C., Stanworth, S.J., Szczepiorkowski, Z.M., Tinmouth, A.T., Wood, E., and ICTMG

Subjects
medicine.medical_specialty, Adrenal cortex hormones, Platelet Transfusion, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, 030225 pediatrics, Internal medicine, Humans, Medicine, Platelet, 030212 general & internal medicine, Fetus, Hematology, biology, Platelet Count, business.industry, Infant, Newborn, Recem nascido, Immunoglobulins, Intravenous, Obstetrics and Gynecology, medicine.disease, Combined Modality Therapy, Human platelet antigen, Thrombocytopenia, Neonatal Alloimmune, Fetal Diseases, Platelet transfusion, Anesthesia, Pediatrics, Perinatology and Child Health, Neonatal alloimmune thrombocytopenia, biology.protein, business, Intracranial Hemorrhages
Abstract

Objective: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is associated with life-threatening bleeding. This systematic review of postnatal management of FNAIT examined transfusion of human platelet antigen (HPA) selected or unselected platelets, and/or IVIg on platelet increments, hemorrhage and mortality. Study design: MEDLINE, EMBASE and Cochrane searches were conducted until 11 May 2018. Result: Of 754 neonates, 382 received platelet transfusions (51%). HPA-selected platelets resulted in higher platelet increments and longer response times than HPA-unselected platelets. However, unselected platelets generally led to sufficient platelet increments to 30 × 10 9 /L, a level above which intracranial hemorrhage or other life-threatening bleeding rarely occurred. Platelet increments were not improved with the addition of IVIg to platelet transfusion. Conclusion: Overall, HPA-selected platelet transfusions were more effective than HPA-unselected platelets but unselected platelets were often effective enough to achieve clinical goals. Available studies do not clearly demonstrate a benefit for addition of IVIg to platelet transfusion.

Published
2019

47. Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia: a systematic review

Author

Kjaer, M., Bertrand, G., Bakchoul, T., Massey, E., Baker, J.M., Lieberman, L., Tanael, S., Greinacher, A., Murphy, M.F., Arnold, D.M., Baidya, S., Bussel, J., Hume, H., Kaplan, C., Oepkes, D., Ryan, G., Savoia, H., Shehata, N., Kjeldsen-Kragh, J., Allard, S., Bianco, C., Callum, J., Compernolle, V., Fergusson, D., Fung, M., Nahirniak, S., Pavenski, K., Pink, J., So-Osman, C., Stanworth, S.J., Szczepiorkowski, Z.M., Wood, E., and Int Collaboration Transfusion Med

Subjects
medicine.medical_specialty, medicine.drug_class, Antibody level, 030204 cardiovascular system & hematology, Monoclonal antibody, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Humans, Medicine, Antigens, Human Platelet, Prospective cohort study, platelet, Fetus, Antibody measurement, biology, Platelet Count, business.industry, Obstetrics, monoclonal antibody immobilization of platelet antigen, maternal HPA-1a antibodies, Infant, Newborn, Integrin beta3, Retrospective cohort study, Hematology, General Medicine, medicine.disease, bleeding, Thrombocytopenia, Neonatal Alloimmune, Neonatal alloimmune thrombocytopenia, biology.protein, Female, alloimmune thrombocytopenia, Antibody, business, Biomarkers, Maternal Serum Screening Tests, 030215 immunology
Abstract

Background and Objectives: In Caucasians, fetal/neonatal alloimmune thrombocytopenia (FNAIT) is most commonly due to maternal HPA-1a antibodies. HPA-1a typing followed by screening for anti-HPA-1a antibodies in HPA-1bb women may identify first pregnancies at risk. Our goal was to review results from previous published studies to examine whether the maternal antibody level to HPA-1a could be used to identify high-risk pregnancies. Materials and Methods: The studies included were categorized by recruitment strategies: screening of unselected pregnancies or samples analyzed from known or suspected FNAIT patients. Results: Three prospective studies reported results from screening programmes, and 10 retrospective studies focused on suspected cases of FNAIT. In 8 studies samples for antibody measurement, performed by the monoclonal antibody immobilization of platelet antigen (MAIPA) assay, and samples for determining fetal/neonatal platelet count were collected simultaneously. In these 8 studies, the maternal antibody level correlated with the risk of severe thrombocytopenia. The prospective studies reported high negative predictive values (88–95%), which would allow for the use of maternal anti-HPA-1a antibody level as a predictive tool in a screening setting, in order to identify cases at low risk for FNAIT. However, due to low positive predictive values reported in prospective as well as retrospective studies (54–97%), the maternal antibody level is less suited for the final diagnosis and for guiding antenatal treatment. Conclusion: HPA-1a antibody level has the potential to predict the severity of FNAIT. (Less)

Published
2019

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