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Objective Histological morphology, immunophenotype and molecular diagnosis of gliomas were reported and classified according to fifth edition of the 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5). Methods Total 60 glioma patients with a clear diagnosis through genetic testing were collected in General Hospital of Southern Theatre Command of Chinese PLA from July 2019 to July 2021. All of them were diagnosed based on histopathology and molecular alterations by HE staining, immunohistochemical staining, and genetic screening and were classified according to the WHO CNS5. Results A total of 60 gliomas, according to WHO CNS5, were classified into one with pilocytic astrocytoma (1.67%), one with ganglioglioma (1.67%), 15 with astrocytomas, IDH⁃mutant (25%), 11 with oligodendrogliomas, IDH⁃mutant and 1p/19q co⁃deleted (18.33%), one with pleomorphic xanthoastrocytoma (1.67%), 21 with glioblastomas, IDH⁃wildtype (35%), 3 with diffuse midline glioma, H3 K27⁃altered (5%) and 7 with glioma, NEC (11.67%). The 7 patients with glioma, NEC were respectively diagnosed based on histopathology as anaplastic astrocytoma in one case, oligodendrogliomas in 2 cases, diffuse astrocytomas in 2 cases, ganglioglioma in one case, and anaplastic oligodendroglioma in one case, with only one case with methylguanine⁃DNA methyltransferase (MGMT) promoter methylation and one case with BRAF V600E mutation by genetic screening. The 21 patients with glioblastoma, IDH⁃wildtype were respectively diagnosed based on histopathology as glioblastoma in 15 cases, oligodendroglioma in one case, anaplastic oligodendroglioma in 2 cases, diffuse astrocytoma in 2 cases and anaplastic astrocytoma in one case, while TERT promoter mutation in 15 cases (71.43%), EGFR amplification in 7 cases (33.33%), MGMT promoter methylation in 5 patients (23.81%) and amplification of chromosome 7 in one case (4.76%). The 15 patients with astrocytoma, IDH⁃mutant, CNS WHO grade 2-4 were diagnosed based on histopathology as glioblastoma in 3 cases, oligodendroglioma in 2 cases, anaplastic oligodendroglioma in one case, diffuse astrocytoma in 8 cases and anaplastic astrocytoma in one case, with MGMT promoter methylation in 11 cases, homozygous deletion of cyclin⁃dependent kinase inhibitor 2A/B (CDKN2A/B) in 2 cases. Conclusions This article is the first pathological diagnosis report of single⁃center glioma since the publication of WHO CNS5, suggesting the WHO CNS5 could more accurately classify gliomas. However, the proportion of glioma, NEC diagnosed is still relatively high. Even well⁃classified gliomas have many differences in genetic signature. The molecular features of gliomas still require further deeply exploration.

Offshore wind power is an important direction of global wind power development. Economical and efficient grid connection of large-scale offshore wind power is a core challenge faced by offshore wind power construction in China. This article first summarizes the development status of offshore wind power in China and abroad and the global development trends. Subsequently, it elaborates the technical characteristics and representative applications of two typical scenarios: grid connection of single offshore wind farms and transmission of large-scale offshore wind power clusters. After analyzing the challenges faced by the grid connection and transmission of offshore wind power in China, we propose an overall development strategy and conduct adaptability analysis on the grid connection and transmission schemes under the aforementioned scenarios. To build first-class offshore wind power grid connection and transmission projects that adapt to China’s national conditions and to promote energy transformation, we propose that China should conduct unified planning after verifying its national resource reserves of offshore wind power; strengthen independent innovation to break through the key technologies; improve the supporting mechanism to ensure high quality development of offshore wind power; and promote international industrial cooperation.

After the power reform No. 9 was released in March 2015, the state officially released the Opinions on the Implementation of the Reform on the Power Sales Side. From this document, we can see that the openness of sales of social capital to the electricity business, the sales side of the market competition through multiple ways to train the main competitors, the result is more users have the right to choose, sales service quality and user energy levels will significantly improve. With the gradual promotion of the electricity sales market, the national electricity sales companies have been established one after another. In addition to power grid outside the power generation companies, energy-saving service companies and distributed power companies may become the main selling power, while industrial parks, commercial complex, large residential area, industrial and commercial users, large industrial users in the new electricity demand appearing The new changes, some power customers have also self-built distributed power supply, installation of energy storage devices or equipment to participate in the transformation of the electricity market. The main body of the electricity sales market has gradually evolved from the traditional electricity generation main body to the multi-unit main body and emerged new value points. Therefore, the electricity sales companies need to establish a power customer value evaluation method and service mode to adapt to the new electricity reform, Provide supportive decision support.