1. Dissemination feature based on PET/CT is a risk factor for diffuse large B cell lymphoma patients outcome
- Author
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Fei Wang, Silu Cui, Luo Lu, Xiaoliang Shao, Feng Yan, Yaqi Liu, Bai He, Jianfeng Wang, Yang Cao, Yanhua Yue, Yuetao Wang, and Weiying Gu
- Subjects
Dissemination ,Distance ,PET/CT ,Diffuse large B-cell lymphoma ,Prognosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background 18F-FDG PET/CT provides precise information about dissemination of lymphoma lesions. Dmax, defined as distance between the two lesions that were farthest apart by PET/CT, was found to be a promising predictor of Diffuse large B-cell lymphoma (DLBCL) outcome in a small size of clinical trial data. We analyzed the impact of Dmax on the outcome of a large real-world DLBCL cohort. Methods Data of newly diagnosed DLBCL at the Third Affiliated Hospital of Soochow University were retrospectively collected. Baseline Dmax, clinical data and survival information were recorded. A metabolic parameter, metabolic bulk volume (MBV), was also measured to verify the independent impact of Dmax. Results Optimal cut-off values for Dmax and MBV were 45.34 cm and 21.65 cm3. With a median follow-up of 32 months, Dmax significantly impacted progression-free survival (PFS) and overall survival (OS) in 253 DLBCL patients. For Dmaxlow and Dmaxhigh groups, estimated 3-year OS were 87.0% and 53.8% (p
- Published
- 2023
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