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144 results on '"Bai, Zhao-fang"'

6. Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

Author

Zhao, Xiao-Mei, primary, Wu, Zhi-Xin, additional, Wang, Yan, additional, Xu, Ying-Jie, additional, Xiu, Ye, additional, Dong, Xu, additional, Li, Jun-Jie, additional, Lv, Gui-Ji, additional, Wang, Si-Hao, additional, Li, Yu-Rong, additional, Bai, Zhao-Fang, additional, and Xiao, Xiao-He, additional

Published
2024
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10. Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial

Author

Wang, Jia-bo, Wang, Zhong-xia, Jing, Jing, Zhao, Peng, Dong, Jing-hui, Zhou, Yong-feng, Yang, Guang, Niu, Ming, Zhao, Xu, Jiang, Tian-jun, Bi, Jing-feng, Xu, Zhe, Zhang, Ping, Wu, Dan, Bai, Zhao-fang, Guo, Yu-ming, Yu, Si-miao, Sun, Yong-qiang, Zhang, Zi-teng, Zhan, Xiao-yan, Li, Peng-yan, Ding, Jin-biao, Zhao, Peng-fei, Song, Xue-ai, Tang, Jian-yuan, He, Dong-chu, Chen, Zhu, Qin, En-qiang, Wang, Rui-lin, and Xiao, Xiao-he

Published
2020
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16. Yin/Yang associated differential responses to Psoralea corylifolia Linn. in rat models: an integrated metabolomics and transcriptomics study

Author

Zhang, Ming-Liang, primary, Zhao, Xu, additional, Li, Wei-Xia, additional, Wang, Xiao-Yan, additional, Niu, Ming, additional, Zhang, Hui, additional, Chen, Yu-Long, additional, Kong, De-Xin, additional, Gao, Yuan, additional, Guo, Yu-Ming, additional, Bai, Zhao-Fang, additional, Xiao, Xiao-he, additional, Zhao, Yan-Ling, additional, and Tang, Jinfa, additional

Published
2022
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19. Metabolomic Profiling of Chronic versus Acute Drug-Induced Liver Injury

Author

Wang, Jiabo, primary, Shi, Zhuo, additional, Wei, Lu-ge, additional, Huang, Ang, additional, Zhai, Xing-ran, additional, Niu, Ming, additional, Xu, Jing, additional, Jing, Jing, additional, He, Ting-ting, additional, Gao, Yuan, additional, Ma, Zhi-tao, additional, Zhao, Xu, additional, Hou, Jun-xing, additional, Guo, Yu-ming, additional, Bai, Zhao-fang, additional, Gong, Man, additional, Yu, Yue-cheng, additional, Zou, Zheng-sheng, additional, and Xiao, Xiao-he, additional

Published
2022
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21. Age-Associated Risk of Liver-Related Adverse Drug Reactions

Author

Han, Yan-zhong, primary, Guo, Yu-ming, additional, Xiong, Peng, additional, Ge, Fei-lin, additional, Jing, Jing, additional, Niu, Ming, additional, Zhao, Xu, additional, Bai, Zhao-fang, additional, Song, Hai-bo, additional, Xiao, Xiao-he, additional, and Wang, Jia-bo, additional

Published
2022
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24. ABCB1 c.3435C > T and EPHX1 c.416A > G polymorphisms influence plasma carbamazepine concentration, metabolism, and pharmacoresistance in epileptic patients

Author

Zhang, Ming-Liang, primary, Chen, Xiao-Long, additional, Bai, Zhao-Fang, additional, Zhao, Xu, additional, Li, Wei-Xia, additional, Wang, Xiao-Yan, additional, Zhang, Hui, additional, Chen, Xiao-Fei, additional, Zhang, Shu-Qi, additional, Tang, Jin-Fa, additional, Xiao, Xiao-He, additional, and Zhao, Yan-Ling, additional

Published
2021
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26. Chinese Patent Medicine Liuweiwuling Tablet had Potent Inhibitory Effects on Both Wild-Type and Entecavir-Resistant Hepatitis B Virus (HBV) in vitro and Effectively Suppressed HBV Replication in Mouse Model

Author

Ge, Fei-lin, primary, Si, Lan-lan, additional, Yang, Yan, additional, Li, Yuan-hua, additional, Lv, Zhong-lin, additional, Liu, Wen-hui, additional, Liao, Hao, additional, Wang, Jun, additional, Zou, Jun, additional, Li, Le, additional, Li, Hui, additional, Zhang, Zi-lin, additional, Wang, Jia-bo, additional, Lu, Xue-chun, additional, Xu, Dong-ping, additional, Bai, Zhao-fang, additional, Liu, Yan, additional, and Xiao, Xiao-he, additional

Published
2021
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28. [Clinical cases and experimental evaluation of liver injury related to anti-psoriasis Keyin Pills]

Author

Xiong, Peng, Chen, Shuai-Shuai, Song, Di, Zhu, Jing-Xiao, Liu, Ya-Lei, Guo, Yu-Ming, Bai, Zhao-Fang, Zhao, Hai-Ping, Wang, Jia-Bo, and Xiao, Xiao-He

Subjects
Dictamnus, Liver, Animals, Humans, Psoriasis, Chemical and Drug Induced Liver Injury, Medicine, Chinese Traditional, Drugs, Chinese Herbal, Rats
Abstract

Keyin Pills is a kind of traditional Chinese medicine for the treatment of psoriasis, but it has been reported that it can cause serious liver injury. In this paper, we used the integrated evidence chain method to retrieve and reevaluate the adverse drug reaction database, CNKI literature and cases of liver injury relating to Keyin Pills in specialist hepatology hospitals. We screened out 23 cases with the causal relationship of the possible grade and above. Among them, 11 cases showed the positive causal relationship only with Keyin Pills, accounting for 47.83%, suggesting that there was objective liver injury caused by Keyin Pills. The incubation period of liver injury caused by Keyin Pills is 1-90 days, and the cumulative dosage span is 20-1 800 g. There were obvious individual diffe-rences. There was no relationship between liver injury as well as dose and course of treatment, suggesting that Keyin Pills could induce immune idiosyncratic liver injury. Furthermore, based on the liver injury model induced by immunological stress, it was confirmed that Keyin Pills could induce acute liver injury in a dose-dependent manner in rats with immunological stress. The toxic dose(14 g·kg~(-1)) of a single dose was 6.7 times of the clinical equivalent dose, and had no significant effect on the biochemical index of liver function and histopathology in normal rats. Decomposition experiments showed that Dictamnus dasycarpus in Keyin Pills is the main medicinal flavor that causes special liver injury, and the other three medicines had neither liver injury nor compatibility attenuation effect. The results suggest that clinical medication shall pay attention to the risk of liver injury caused by Keyin Pills in patients with immunological stress.

Published
2020

29. Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer

Author

Pan, Xin, Zhou, Tao, Tai, Yan-Hong, Wang, Chenguang, Zhao, Jie, Cao, Yuan, Chen, Yuan, Zhang, Pei-Jing, Yu, Ming, Zhen, Cheng, Mu, Rui, Bai, Zhao-Fang, Li, Hui-Yan, Li, Ai-Ling, Liang, Bing, Jian, Zhao, Zhang, Wei-Na, Man, Jiang-Hong, Gao, Yan-Fei, Gong, Wei-Li, Wei, Li-Xin, and Zhang, Xue-Min

Subjects
Gene expression -- Research -- Genetic aspects -- Health aspects, Hormone therapy -- Health aspects -- Research, Breast cancer -- Care and treatment -- Research -- Genetic aspects, Biological sciences, Health
Abstract

Endocrine resistance is a major obstacle to hormonal therapy for breast cancers. Although reduced expression of estrogen receptor-α (ER-α) is a known contributing factor to endocrine resistance, the mechanism of ER-α downregulation in endocrine resistance is still not fully understood. Here we report that CUE domain-containing protein-2 (CUEDC2), a ubiquitin-binding motif-containing protein, is a key factor in endocrine resistance in breast cancer. We show that CUEDC2 modulates ER-α protein stability through the ubiquitin-proteasome pathway. Through the study of specimens from a large cohort of subjects with breast cancer, we found a strong inverse correlation between CUEDC2 and ER-α protein expression. Notably, subjects with tumors that highly expressed CUEDC2 had poor responsiveness to tamoxifen treatment and high potential for relapse. We further show that ectopic CUEDC2 expression impaired the responsiveness of breast cancer cells to tamoxifen. Therefore, our findings suggest that CUEDC2 is a crucial determinant of resistance to endocrine therapies in breast cancer., The CUE domains are small, moderately conserved ubiquitin-binding domains of ~40 amino acids; they are found in a variety of eukaryotic proteins (1,2). These proteins are involved in the recognition [...]

Published
2011
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31. Epigallocatechin Gallate During Dietary Restriction — Potential Mechanisms of Enhanced Liver Injury

Author

Shi, Zhuo, primary, Zhu, Jing-xiao, additional, Guo, Yu-ming, additional, Niu, Ming, additional, Zhang, Le, additional, Tu, Can, additional, Huang, Ying, additional, Li, Peng-yan, additional, Zhao, Xu, additional, Zhang, Zi-teng, additional, Bai, Zhao-fang, additional, Zhang, Guang-qin, additional, Lu, Yang, additional, Xiao, Xiao-he, additional, and Wang, Jia-bo, additional

Published
2021
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33. Author Correction: Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ

Author

Meng, Ya-kun, primary, Li, Chun-yu, additional, Li, Rui-yu, additional, He, Lan-zhi, additional, Cui, He-rong, additional, Yin, Ping, additional, Zhang, Cong-en, additional, Li, Peng-yan, additional, Sang, Xiu-xiu, additional, Wang, Ya, additional, Niu, Ming, additional, Zhang, Ya-ming, additional, Guo, Yu-ming, additional, Sun, Rong, additional, Wang, Jia-bo, additional, Bai, Zhao-fang, additional, and Xiao, Xiao-he, additional

Published
2020
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34. Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study

Author

Huang, Ying, primary, Zhao, Xu, additional, Zhang, Zi-teng, additional, Chen, Shuai-shuai, additional, Li, Shan-shan, additional, Shi, Zhuo, additional, Jing, Jing, additional, Huang, Ang, additional, Guo, Yu-ming, additional, Bai, Zhao-fang, additional, Zou, Zheng-sheng, additional, Xiao, Xiao-he, additional, Wang, Jia-bo, additional, and Niu, Ming, additional

Published
2020
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37. Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb-Polygonum multiflorumthunb. induced liver injury: a case-control study from a specialised liver disease center in China

Author

Jing, Jing, primary, Wang, Rui-lin, additional, Zhao, Xin-yan, additional, Zhu, Yun, additional, Niu, Ming, additional, Wang, Li-fu, additional, Song, Xue-ai, additional, He, Ting-ting, additional, Sun, Yong-qiang, additional, Xu, Wen-tao, additional, Yu, Si-miao, additional, Wang, Li-ping, additional, Guo, Yu-ming, additional, Bai, Zhao-fang, additional, Xiao, Xiao-he, additional, and Wang, Jia-bo, additional

Published
2019
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38. A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure

Author

Wang, Jia-bo, primary, Cui, He-rong, additional, Wang, Rui-lin, additional, Zhang, Cong-en, additional, Niu, Ming, additional, Bai, Zhao-fang, additional, Xu, Gen-hua, additional, Li, Peng-yan, additional, Jiang, Wen-yan, additional, Han, Jing-jing, additional, Ma, Xiao, additional, Cai, Guang-ming, additional, Li, Rui-sheng, additional, Zhang, Li-ping, additional, and Xiao, Xiao-he, additional

Published
2018
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39. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

Author

Song, Nan, primary, Liu, Zhao-Shan, additional, Xue, Wen, additional, Bai, Zhao-Fang, additional, Wang, Qian-Yi, additional, Dai, Jiang, additional, Liu, Xin, additional, Huang, Yi-Jiao, additional, Cai, Hong, additional, Zhan, Xiao-Yan, additional, Han, Qiu-Ying, additional, Wang, Hongxia, additional, Chen, Yuan, additional, Li, Hui-Yan, additional, Li, Ai-Ling, additional, Zhang, Xue-Min, additional, Zhou, Tao, additional, and Li, Tao, additional

Published
2017
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42. Oxymatrine attenuates CCl 4 -induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways

Author

Zhao, Hong-wei, primary, Zhang, Zhen-fang, additional, Chai, Xuan, additional, Li, Guang-quan, additional, Cui, He-rong, additional, Wang, Hong-bo, additional, Meng, Ya-kun, additional, Liu, Hui-min, additional, Wang, Jia-bo, additional, Li, Rui-sheng, additional, Bai, Zhao-fang, additional, and Xiao, Xiao-he, additional

Published
2016
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45. Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study

Author

Dong, Qin, primary, Li, Na, additional, Li, Qi, additional, Zhang, Cong-En, additional, Feng, Wu-Wen, additional, Li, Guang-Quan, additional, Li, Rui-Yu, additional, Tu, Can, additional, Han, Xue, additional, Bai, Zhao-Fang, additional, Zhang, Ya-Ming, additional, Niu, Ming, additional, Ma, Zhi-Jie, additional, Xiao, Xiao-He, additional, and Wang, Jia-Bo, additional

Published
2015
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46. Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon Cancer

Author

Chen, Yuan, primary, Wang, Shao-Xin, additional, Mu, Rui, additional, Luo, Xue, additional, Liu, Zhao-Shan, additional, Liang, Bing, additional, Zhuo, Hai-Long, additional, Hao, Xiao-Peng, additional, Wang, Qiong, additional, Fang, Di-Feng, additional, Bai, Zhao-Fang, additional, Wang, Qian-Yi, additional, Wang, He-Mei, additional, Jin, Bao-Feng, additional, Gong, Wei-Li, additional, Zhou, Tao, additional, Zhang, Xue-Min, additional, Xia, Qing, additional, and Li, Tao, additional

Published
2014
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47. Hepatobiliary and pancreatic: Comparison between Chinese herbal medicine and Western medicine-induced liver injury of 1985 patients.

Author

Zhu, Yun, Niu, Ming, Chen, Jing, Zou, Zheng‐sheng, Ma, Zhi‐jie, Liu, Shu‐hong, Wang, Rui‐lin, He, Ting‐ting, Song, Hai‐bo, Wang, Zhong‐xia, Pu, Shi‐biao, Ma, Xiao, Wang, Li‐fu, Bai, Zhao‐fang, Zhao, Yan‐ling, Li, Yong‐gang, Wang, Jia‐bo, and Xiao, Xiao‐he

Subjects
LIVER injuries, DRUG side effects, CHINESE medicine, HERBAL medicine, POLYGONUM multiflorum, INJURY risk factors, THERAPEUTICS
Abstract

Background and Aim Chinese herbal medicine (CHM), as well as Western medicine (WM), is an important cause of drug-induced liver injury (DILI). However, the differences between CHM and WM as agents implicated in liver injury have rarely been reported. Methods Overall, 1985 (2.05%) DILI cases were retrospectively collected from the 96 857 patients hospitalized because of liver dysfunction in the 302 Military Hospital between January 2009 and January 2014. Results In all the enrolled patients with DILI, CHM was implicated in 563 cases (28.4%), while 870 cases (43.8%) were caused by WM and the remaining patients (27.8%) by the combination of WM and CHM. Polygonum multiflorum was the major implicated CHM. Compared with WM, the cases caused by CHM showed more female (51 vs 71%, P < 0.001) and positive rechallenge (6.1 vs 8.9%, P = 0.046), a much greater proportion of hepatocellular injury (62.2 vs 88.5%, P < 0.001), and a higher mortality (2.8 vs 4.8%, P = 0.042); however, no differences in the rates of chronic DILI and ALF were found (12.9 vs 12.4%, P = 0.807; 7.6 vs 7.6%, P = 0.971). Based on Roussel Uclaf Causality Assessment Method, 75.6% of cases caused by CHM were classified as probable and only 16.6% as highly probable, significantly different from WM (38.4 and 60.3%, all P < 0.001). Conclusions The causal relationship between CHM and liver injury is much complex, and the clinical characteristics of DILI caused by CHM differ from those caused by WM. [ABSTRACT FROM AUTHOR]

Published
2016
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48. Cis-stilbene glucoside in Polygonum multifloruminduces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-?

Author

Meng, Ya-kun, Li, Chun-yu, Li, Rui-yu, He, Lan-zhi, Cui, He-rong, Yin, Ping, Zhang, Cong-en, Li, Peng-yan, Sang, Xiu-xiu, Wang, Ya, Niu, Ming, Zhang, Ya-ming, Guo, Yu-ming, Sun, Rong, Wang, Jia-bo, Bai, Zhao-fang, and Xiao, Xiao-he

Abstract

The root of Polygonum multiflorumThunb (PM) has been used in China to treat a variety of diseases, such as constipation, early graying of the hair and hyperlipemia. Recent evidence shows that PM causes idiosyncratic drug-induced liver injury (IDILI) in humans. In this study, we investigated the molecular basis of PM-induced liver injury in a rat model of IDILI based on a non-hepatotoxic dose of LPS. SD rats were orally administered 3 potentially hepatotoxic compounds of PM: cis-stilbene glucoside (cis-SG, 50 mg/kg), trans-SG (50 mg/kg) or emodin (5 mg/kg), followed by injection of LPS (2.8 mg/kg, iv). Serum and liver histology were evaluated 7 h after LPS injection. Among the 3 compounds tested, cis-SG, but not emodin or trans-SG, induced severe liver injury in rats when combined with LPS. The levels of AST and ALT in plasma and inflammatory cytokines in both plasma and liver tissues were markedly elevated. The liver tissues showed increased injury, hepatocyte apoptosis, and macrophage infiltration, and decreased cell proliferation. Microarray analysis revealed a negative correlation between peroxisome proliferator-activated receptor-? (PPAR-?) and LPS/cis-SG-induced liver injury. Immunohistochemical staining and RT-PCR results further confirmed that cis-SG significantly inhibited activation of the PPAR-? pathway in the liver tissues of LPS/cis-SG-treated rats. Pre-treatment with a PPAR-? agonist pioglitazone (500 g/kg, ig) reversed LPS/cis-SG-induced liver injury, which was associated with inhibiting the nuclear factor kappa B (NF-?B) pathway. These data demonstrate that cis-stilbene glucoside induces immunological idiosyncratic hepatotoxicity through suppressing PPAR-? in a rat model of IDILI.

Published
2017
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49. Author Correction: Cis-stilbene glucoside in Polygonum multifloruminduces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ

Author

Meng, Ya-kun, Li, Chun-yu, Li, Rui-yu, He, Lan-zhi, Cui, He-rong, Yin, Ping, Zhang, Cong-en, Li, Peng-yan, Sang, Xiu-xiu, Wang, Ya, Niu, Ming, Zhang, Ya-ming, Guo, Yu-ming, Sun, Rong, Wang, Jia-bo, Bai, Zhao-fang, and Xiao, Xiao-he

Abstract

A Correction to this paper has been published: https://doi.org/10.1038/s41401-020-00592-2

Published
2021
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50. [Mechanism of total glucosides of White Paeony Capsules in ameliorating acute lung injury based on NLRP3 inflammasome].

Author

Xu YJ, Wang XL, Mu WQ, Wen JC, Wang Y, Xiu Y, Dong X, Li JJ, Zhan XY, Xiao XH, and Bai ZF

Subjects
Animals, Mice, Male, Capsules, Lung drug effects, Lung immunology, Lung metabolism, Humans, Interleukin-1beta genetics, Interleukin-1beta immunology, Interleukin-1beta metabolism, Acute Lung Injury drug therapy, Acute Lung Injury metabolism, Acute Lung Injury immunology, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, NLR Family, Pyrin Domain-Containing 3 Protein genetics, Glucosides pharmacology, Glucosides chemistry, Mice, Inbred C57BL, Inflammasomes metabolism, Inflammasomes drug effects, Paeonia chemistry, Drugs, Chinese Herbal administration & dosage, Drugs, Chinese Herbal pharmacology, Drugs, Chinese Herbal chemistry
Abstract

This study deciphered the ameliorating effect and molecular mechanism of the total glucosides of White Paeony Capsules(TGP) in the treatment of mice model with acute lung injury(ALI) via NOD-like receptor thermal protein domain associated protein 3(NLRP3) signaling pathway of the inflammasome. The study established an inflammasome activation model of primed bone marrow-derived macrophages(BMDMs), and its molecular mechanism was investigated by Western blot(WB), immunofluorescence staining, enzyme-linked immunosorbent assay(ELISA), and flow cytometry. C57BL/6J mice were randomly divided into a blank control group, a TGP group, a model group(LPS group), LPS+low-and high-dose TGP groups, LPS+MCC950 group, and LPS+MCC950+TGP group, with eight mice per group. The ALI model was induced in mice. Finally, bronchoalveolar lavage fluid(BALF) and lung tissue were collected. Lung index and lung weight wet-to-dry ratio were determined for each group of mice. The pathological changes in lung tissue were observed through hematoxylin-eosin(HE) staining. The number of neutrophils in the BALF of each group was detected using flow cytometry. The levels of interleukin(IL)-1β, IL-6, and tumor necrosis factor(TNF)-α in the BALF were determined by ELISA. The expressions of IL-1β, IL-18, IL-6, and TNF-α in the lung tissue were determined by real-time quantitative PCR(RT-qPCR). This study demonstrated that TGP dramatically blocked the activation of the NLRP3 inflammasome by inhibiting the production of upstream mitochondrial reactive oxygen species(mtROS) and the subsequent oligomerization of apoptosis-associated specks(ASC). Additionally, in the ALI mice model, compared with the blank control group, the model group showed alveolar structure rupture, thic-kening of alveolar septa, and dramatically increased lung index, lung weight wet-to-dry ratio in lung tissue, neutrophil count, and inflammatory factor levels. Compared with the model group, the pathological morphology of lung tissue was significantly ameliorated in the TGP and MCC950 groups, and the lung index and lung weight wet-to-dry ratio were significantly reduced. Neutrophil counts were reduced, and levels of inflammatory factors were significantly downregulated. Notably, compared with the MCC950 group, there was no significant difference in effect in the MCC950+TGP group. Collectively, the study reveals that TGP may ameliorate ALI in mice by inhibiting the activation of NLRP3 inflammasome, providing a safe and effective drug candidate for the prevention or treatment of ALI/ARDS.

Published
2024
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