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1. Improving Hepatitis B Care in the US: A Case for a New "Ryan White" Program

Author: Alpern, Jonathan D, Leventhal, Thomas M, and Bahr, Nathan C
Published: 2020
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2. Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa

Author: Sekar, Preethiya, Hale, Gila, Gakuru, Jane, Meya, David B., Boulware, David R., Ellis, Jayne, Nalintya, Elizabeth, Bahr, Nathan C., and Rajasingham, Radha
Subjects: Urine -- Analysis, Antigens -- Measurement -- Health aspects, Histoplasmosis -- Statistics -- Risk factors -- Diagnosis, HIV patients -- Statistics, Immunologic diseases -- Statistics -- Risk factors -- Diagnosis
Abstract: Histoplasmosis is an endemic fungal infection caused by Histoplasma capsulatum. In immunocompetent persons, histoplasmosis is often asymptomatic or localized to the pulmonary system. However, in immunocompromised persons, histoplasmosis can manifest [...]
Published: 2024
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3. The Effect of Structural Violence on Patients with Sickle Cell Disease

Author: Bahr, Nathan C and Song, John
Published: 2015
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4. Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis

Author: Musubire, Abdu, Kagimu, Enock, Mugabi, Timothy, Meya, David B., Boulware, David R., and Bahr, Nathan C.
Published: 2024
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5. Advancing Diagnosis and Treatment in People Living with HIV and Tuberculosis Meningitis

Author: Kimuda, Sarah, Kasozi, Derrick, Namombwe, Suzan, Gakuru, Jane, Mugabi, Timothy, Kagimu, Enock, Rutakingirwa, Morris K., Leon, Kristoffer E., Chow, Felicia, Wasserman, Sean, Boulware, David R., Cresswell, Fiona V., and Bahr, Nathan C.
Published: 2023
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6. Noninvasive Testing and Surrogate Markers in Invasive Fungal Diseases

Author: Thompson, George R, Boulware, David R, Bahr, Nathan C, Clancy, Cornelius J, Harrison, Thomas S, Kauffman, Carol A, Le, Thuy, Miceli, Marisa H, Mylonakis, Eleftherios, Nguyen, M Hong, Ostrosky-Zeichner, Luis, Patterson, Thomas F, Perfect, John R, Spec, Andrej, Kontoyiannis, Dimitrios P, and Pappas, Peter G
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Emerging Infectious Diseases, Prevention, Infectious Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Infection, Good Health and Well Being, diagnosis, fungal infections, mycology, Clinical sciences, Medical microbiology
Abstract: Invasive fungal infections continue to increase as at-risk populations expand. The high associated morbidity and mortality with fungal diseases mandate the continued investigation of novel antifungal agents and diagnostic strategies that include surrogate biomarkers. Biologic markers of disease are useful prognostic indicators during clinical care, and their use in place of traditional survival end points may allow for more rapid conduct of clinical trials requiring fewer participants, decreased trial expense, and limited need for long-term follow-up. A number of fungal biomarkers have been developed and extensively evaluated in prospective clinical trials and small series. We examine the evidence for these surrogate biomarkers in this review and provide recommendations for clinicians and regulatory authorities.
Published: 2022

7. Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Author: Martín-Vallejo, Francisco Javier, Zdziarski, Przemyslaw, Zarrinfer, Hossein, Wittig, Jana, Win, Sein, Wai-Man, Vivien, Víšek, Benjamín, Vinh, Donald C., Vehreschild, Maria, Varricchio, Gina, Tsirigotis, Panagiotis, Torres-Tienza, Ana, Tanase, Alina Daniela, Tafuri, Agostino, Stamouli, Maria, Sramek, Jiří, Soussain, Carole, Shirinova, Ayten, Schubert, Jörg, Schalk, Enrico, Salehi, Mohammad Reza, Saleh, Modar, Rosati, Giorgio, Roldán, Elisa, Reizine, Florian, Rêgo, Mayara, Regalado-Artamendi, Isabel, Popova, Marina, Pinto, Fernando, Philippe, Laure, Orth, Hans Martin, Ommen, Hans-Beier, Obr, Aleš, Núñez-Martín-Buitrago, Lucía, Noël, Nicolas, Neuhann, Julia, Nadali, Gianpaolo, Nacov, Julia A., Munhoz Alburquerque, Ana M., Mitra, Maria Enza, Mikulska, Malgorzata, Mellinghoff, Sibylle, Mechtel, Ben, Martín-González, Juan-Alberto, Malak, Sandra, Loureiro-Amigo, Jorge, Lorenzo De La Peña, Lisset, Liberti, Giulia, Landau, Marianne, Lacej, Ira, Kolditz, Martin, Kho, Chi Shan, Khedr, Reham Abdelaziz, Karthaus, Meinolf, Karlsson, Linda Katharina, Jiménez-Lorenzo, María-Josefa, Izuzquiza, Macarena, Hoell-Neugebauer, Baerbel, Herbrecht, Raoul, Heath, Christopher H., Guolo, Fabio, Grothe, Jan, Giordano, Antonio, Gerasymchuk, Sergey, García-Sanz, Ramón, García-Poutón, Nicole, Funke, Vaneuza Araújo Moreira, Fung, Monica, Flasshove, Charlotte, Fianchi, Luana, Essame, Jenna, Egger, Matthias, Drenou, Bernard, Dragonetti, Giulia, Desole, Maximilian, Della Pepa, Roberta, Deau Fischer, Bénédicte, De Kort, Elizabeth, De Cabo, Erik, Danion, François, Daguindau, Etienne, Cushion, Tania, Cremer, Louise, Criscuolo, Marianna, Cordini, Gregorio, Cingolani, Antonella, Ciceri, Fabio, Chowdhury, Fazle Rabbi, Chelysheva, Ekaterina, Chauchet, Adrien, Chai, Louis Yi Ann, Ceesay, M. Mansour, Busch, Elena, Brehon, Mathias, Borducchi, Davimar M.M., Booth, Stephen, Bologna, Serge, Berg Venemyr, Caroline, Bailén-Almorox, Rebeca, Antoniadou, Anastasia, Anastasopoulou, Amalia N., Altuntaş, Fevzi, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes Da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, Vian Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola S., Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-VUKIČEVIĆ, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S., Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques De Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Shumilov, Evgenii, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Quattrone, Martina, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio
Published: 2024
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8. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Author: MARQUES DE ALMEIDA, Joyce, HERNÁNDEZ-RIVAS, José-Ángel, GUIDETTI, Anna, FINIZIO, Olimpia, STOJANOSKI, Zlate, CVETANOSKI, Milche, MELETIADIS, Joseph, DE JONGE, Nick, ANTIĆ, Darko, ALI, Natasha, TISI, Maria Chiara, SERRANO, Laura, PLANTEFEVE, Gaëtan, KHANNA, Nina, HOENIGL, Martin, ČERŇAN, Martin, MIRANDA-CASTILLO, Carolina, FERNÁNDEZ-GALÁN, María, SERRIS, Alexandra, ERBEN, Nurettin, DULÉRY, Rémy, AUJAYEB, Avinash, PAPA, Mario Virgilio, NOVÁK, Jan, DELIA, Mario, SAPIENZA, Giuseppe, REIZINE, Florian, OMRANI, Ali S., DI BLASI, Roberta, LAMURE, Sylvain, DRGOŇA, Ľuboš, COPPOLA, Nicola, BATINIĆ, Josip, AL-KHABORI, Murtadha, RIBERA-SANTA SUSANA, José-María, PIEDIMONTE, Monica, LOUREIRO-AMIGO, Jorge, FOUQUET, Guillemette, FAZZI, Rita, DANION, François, SCHUBERT, Jörg, HOELL-NEUGEBAUER, Baerbel, BAHR, Nathan C., YAHIA, Ayel Omar, TORRES-ATIENZA, Ana, RINALDI, Ikhwan, POPOVA, Marina, OMMEN, Hans-Beier, MITRA, Maria Enza, MIKULSKA, Malgorzata, LACEJ, Ira, KHOSTELIDI, Sofya, WIN, Sein, VINH, Donald, SALEH, Modar, PRATTES, Juergen, JINDRA, Pavel, GUOLO, Fabio, DELLA PEPA, Roberta, CHELYSHEVA, Ekaterina, ZDZIARSKI, Przemyslaw, WAI-MAN, Vivien, SOTO-SILVA, Andrés, ORTH, Hans Martin, MALAK, Sandra, LORENZO DE LA PEÑA, Lisset, KOLDITZ, Martin, Shan KHO, Chi, HEATH, Christopher H., GROH, Ana, GAVRIILAKI, Eleni, FUNG, Monica, EGGER, Matthias, DE KORT, Elizabeth, DE CABO, Erik, CUSHION, Tania, CHOWDHURY, Fazle Rabbi, CEESAY, M. Mansour, BREHON, Mathias, VARRICCHIO, Gina, TAFURI, Agostino, JIMÉNEZ-LORENZO, María-Josefa, KLIMKO, Nikolai, TSIRIGOTIS, Panagiotis, ANTONIADOU, Anastasia, VEHRESCHILD, Maria, Rossi, Giuseppe, Salmanton-García, Jon, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, Martín-Pérez, Sonia, Itri, Federico, López-García, Alberto, Glenthøj, Andreas, Gomes da Silva, Maria, Besson, Caroline, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M., Van Doesum, Jaap, Farina, Francesca, Žák, Pavel, Verga, Luisa, Collins, Graham P., Bonuomo, Valentina, Van Praet, Jens, Nucci, Marcio, Meers, Stef, Espigado, Ildefonso, Fracchiolla, Nicola S., Valković, Toni, Poulsen, Christian Bjørn, Čolović, Natasha, Dragonetti, Giulia, Ledoux, Marie-Pierre, Tascini, Carlo, Buquicchio, Caterina, Blennow, Ola, Passamonti, Francesco, Machado, Marina, Labrador, Jorge, Duarte, Rafael F., Schönlein, Martin, Prezioso, Lucia, Falces-Romero, Iker, Kulasekararaj, Austin, Garcia-Vidal, Carolina, Fernández, Noemí, Abu-Zeinah, Ghaith, Ormazabal-Vélez, Irati, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Cuccaro, Annarosa, Magliano, Gabriele, Szotkowski, Tomáš, González-López, Tomás-José, El-Ashwah, Shaimaa, Bergantim, Rui, Sili, Uluhan, Maertens, Johan, Demirkan, Fatih, De Ramón, Cristina, Petzer, Verena, Del Principe, Maria Ilaria, Navrátil, Milan, Dargenio, Michelina, Seval, Guldane Cengiz, Samarkos, Michail, Ráčil, Zdeněk, Pinczés, László Imre, Lahmer, Tobias, Busca, Alessandro, Méndez, Gustavo-Adolfo, Vena, Antonio, Biernat, Monika M., Merelli, Maria, Calbacho, Maria, Barać, Aleksandra, Bavastro, Martina, Limongelli, Alessandro, Ilhan, Osman, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Mišković, Bojana, Gräfe, Stefanie K., Mladenović, Miloš, Aiello, Tommaso Francesco, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Arellano, Elena, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Cabirta, Alba, Sacchi, Maria Vittoria, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Hanakova, Michaela, Rahimli, Laman, Cordoba, Raul, Cornely, Oliver A., and Pagano, Livio
Published: 2023
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9. Endemic mycoses – are we making progress in management?

Author: Bahr, Nathan C. and Thompson, George R., III
Published: 2023
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10. Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward

Author: Donovan, Joseph, Cresswell, Fiona V, Thuong, Nguyen Thuy Thuong, Boulware, David R, Thwaites, Guy E, Bahr, Nathan C, Aarnoutse, Rob E, Anderson, Suzanne TB, Bang, Nguyen D, Boyles, Tom, te Brake, Lindsey HM, Chandra, Satish, Chow, Felicia C, van Crevel, Reinout, Davis, Angharad G, Dian, Sofiati, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imran, Darma, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, van Toorn, Ronald, Tucker, Elizabeth W, Wasserman, Sean A, and Wilkinson, Robert J
Subjects: Rare Diseases, Tuberculosis, Infectious Diseases, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Diagnostic Tests, Routine, Humans, Molecular Diagnostic Techniques, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Meningeal, Tuberculous Meningitis International Research Consortium, Ultra, Xpert, cerebrospinal fluid, diagnosis, tuberculous meningitis, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract: The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to "rule out" TBM.
Published: 2020

11. Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Author: Salmanton-García, Jon, primary, Marchesi, Francesco, additional, Farina, Francesca, additional, Weinbergerová, Barbora, additional, Itri, Federico, additional, Dávila-Valls, Julio, additional, Martín-Pérez, Sonia, additional, Glenthøj, Andreas, additional, Hersby, Ditte Stampe, additional, Gomes Da Silva, Maria, additional, Nunes Rodrigues, Raquel, additional, López-García, Alberto, additional, Córdoba, Raúl, additional, Bilgin, Yavuz M., additional, Falces-Romero, Iker, additional, El-Ashwah, Shaimaa, additional, Emarah, Ziad, additional, Besson, Caroline, additional, Kohn, Milena, additional, Van Doesum, Jaap, additional, Ammatuna, Emanuele, additional, Marchetti, Monia, additional, Labrador, Jorge, additional, Zambrotta, Giovanni Paolo Maria, additional, Verga, Luisa, additional, Jaksic, Ozren, additional, Nucci, Marcio, additional, Piukovics, Klára, additional, Cabirta-Touzón, Alba, additional, Jiménez, Moraima, additional, Arellano, Elena, additional, Espigado, Ildefonso, additional, Blennow, Ola, additional, Nordlander, Anna, additional, Meers, Stef, additional, Vian Praet, Jens, additional, Aiello, Tommaso Francesco, additional, Garcia-Vidal, Carolina, additional, Fracchiolla, Nicola S., additional, Sciumè, Mariarita, additional, Seval, Guldane Cengiz, additional, Žák, Pavel, additional, Buquicchio, Caterina, additional, Tascini, Carlo, additional, Gräfe, Stefanie K., additional, Schönlein, Martin, additional, Adžić-VUKIČEVIĆ, Tatjana, additional, Bonuomo, Valentina, additional, Cattaneo, Chiara, additional, Nizamuddin, Summiya, additional, Čerňan, Martin, additional, Plantefeve, Gaëtan, additional, Prin, Romane, additional, Szotkovski, Tomas, additional, Collins, Graham P., additional, Dargenio, Michelina, additional, Petzer, Verena, additional, Wolf, Dominik, additional, Čolović, Natasha, additional, Prezioso, Lucia, additional, Valković, Toni, additional, Passamonti, Francesco, additional, Méndez, Gustavo-Adolfo, additional, Sili, Uluhan, additional, Vena, Antonio, additional, Bavastro, Martina, additional, Limongelli, Alessandro, additional, Duarte, Rafael F., additional, Ledoux, Marie-Pierre, additional, Cvetanoski, Milche, additional, Stojanoski, Zlate, additional, Machado, Marina, additional, Batinić, Josip, additional, Magliano, Gabriele, additional, Biernat, Monika M., additional, Pantić, Nikola, additional, Poulsen, Christian Bjørn, additional, Cuccaro, Annarosa, additional, Del Principe, Maria Ilaria, additional, Kulasekararaj, Austin, additional, Ormazabal-Vélez, Irati, additional, Busca, Alessandro, additional, Demirkan, Fatih, additional, Ijaz, Marriyam, additional, Klimko, Nikolai, additional, Stoma, Igor, additional, Khostelidi, Sofya, additional, Fernández, Noemí, additional, Omrani, Ali S., additional, Bergantim, Rui, additional, De Jonge, Nick, additional, Fouquet, Guillemette, additional, Navrátil, Milan, additional, Abu-Zeinah, Ghaith, additional, Samarkos, Michail, additional, Maertens, Johan, additional, De Ramón, Cristina, additional, Guidetti, Anna, additional, Magyari, Ferenc, additional, González-López, Tomás José, additional, Lahmer, Tobias, additional, Finizio, Olimpia, additional, Ali, Natasha, additional, Pinczés, László Imre, additional, Lavilla-Rubira, Esperanza, additional, Romano, Alessandra, additional, Merelli, Maria, additional, Delia, Mario, additional, Calbacho, Maria, additional, Meletiadis, Joseph, additional, Antić, Darko, additional, Hernández-Rivas, José-Ángel, additional, Marques De Almeida, Joyce, additional, Al-Khabori, Murtadha, additional, Hoenigl, Martin, additional, Tisi, Maria Chiara, additional, Khanna, Nina, additional, Barać, Aleksandra, additional, Eisa, Noha, additional, Di Blasi, Roberta, additional, Liévin, Raphaël, additional, Miranda-Castillo, Carolina, additional, Bahr, Nathan C., additional, Lamure, Sylvain, additional, Papa, Mario Virgilio, additional, Yahya, Ayel, additional, Aujayeb, Avinash, additional, Novák, Jan, additional, Erben, Nurettin, additional, Fernández-Galán, María, additional, Ribera-Santa Susana, José-María, additional, Rinaldi, Ikhwan, additional, Fazzi, Rita, additional, Piedimonte, Monica, additional, Duléry, Rémy, additional, Gonzaga, Yung, additional, Soto-Silva, Andrés, additional, Sapienza, Giuseppe, additional, Serris, Alexandra, additional, Drgoňa, Ľuboš, additional, Groh, Ana, additional, Serrano, Laura, additional, Gavriilaki, Eleni, additional, Tragiannidis, Athanasios, additional, Prattes, Juergen, additional, Coppola, Nicola, additional, Otašević, Vladimir, additional, Mladenović, Miloš, additional, Mitrović, Mirjana, additional, Mišković, Bojana, additional, Jindra, Pavel, additional, Zompi, Sofia, additional, Sacchi, Maria Vittoria, additional, Krekeler, Carolin, additional, Shumilov, Evgenii, additional, Infante, Maria Stefania, additional, García-Bordallo, Daniel, additional, Çolak, Gökçe Melis, additional, Cingolani, Antonella, additional, Mayer, Jiří, additional, Criscuolo, Marianna, additional, Nygaard, Marietta, additional, Hanáková, Michaela, additional, Fianchi, Luana, additional, Ráčil, Zdeněk, additional, Giordano, Antonio, additional, Quattrone, Martina, additional, Bonanni, Matteo, additional, Koehler, Philipp, additional, Rahimli, Laman, additional, Cornely, Oliver A., additional, Pagano, Livio, additional, Martín-Vallejo, Francisco Javier, additional, Zdziarski, Przemyslaw, additional, Zarrinfer, Hossein, additional, Wittig, Jana, additional, Win, Sein, additional, Wai-Man, Vivien, additional, Víšek, Benjamín, additional, Vinh, Donald C., additional, Vehreschild, Maria, additional, Varricchio, Gina, additional, Tsirigotis, Panagiotis, additional, Torres-Tienza, Ana, additional, Tanase, Alina Daniela, additional, Tafuri, Agostino, additional, Stamouli, Maria, additional, Sramek, Jiří, additional, Soussain, Carole, additional, Shirinova, Ayten, additional, Schubert, Jörg, additional, Schalk, Enrico, additional, Salehi, Mohammad Reza, additional, Saleh, Modar, additional, Rosati, Giorgio, additional, Roldán, Elisa, additional, Reizine, Florian, additional, Rêgo, Mayara, additional, Regalado-Artamendi, Isabel, additional, Popova, Marina, additional, Pinto, Fernando, additional, Philippe, Laure, additional, Orth, Hans Martin, additional, Ommen, Hans-Beier, additional, Obr, Aleš, additional, Núñez-Martín-Buitrago, Lucía, additional, Noël, Nicolas, additional, Neuhann, Julia, additional, Nadali, Gianpaolo, additional, Nacov, Julia A., additional, Munhoz Alburquerque, Ana M., additional, Mitra, Maria Enza, additional, Mikulska, Malgorzata, additional, Mellinghoff, Sibylle, additional, Mechtel, Ben, additional, Martín-González, Juan-Alberto, additional, Malak, Sandra, additional, Loureiro-Amigo, Jorge, additional, Lorenzo De La Peña, Lisset, additional, Liberti, Giulia, additional, Landau, Marianne, additional, Lacej, Ira, additional, Kolditz, Martin, additional, Kho, Chi Shan, additional, Khedr, Reham Abdelaziz, additional, Karthaus, Meinolf, additional, Karlsson, Linda Katharina, additional, Jiménez-Lorenzo, María-Josefa, additional, Izuzquiza, Macarena, additional, Hoell-Neugebauer, Baerbel, additional, Herbrecht, Raoul, additional, Heath, Christopher H., additional, Guolo, Fabio, additional, Grothe, Jan, additional, Gerasymchuk, Sergey, additional, García-Sanz, Ramón, additional, García-Poutón, Nicole, additional, Funke, Vaneuza Araújo Moreira, additional, Fung, Monica, additional, Flasshove, Charlotte, additional, Essame, Jenna, additional, Egger, Matthias, additional, Drenou, Bernard, additional, Dragonetti, Giulia, additional, Desole, Maximilian, additional, Della Pepa, Roberta, additional, Deau Fischer, Bénédicte, additional, De Kort, Elizabeth, additional, De Cabo, Erik, additional, Danion, François, additional, Daguindau, Etienne, additional, Cushion, Tania, additional, Cremer, Louise, additional, Cordini, Gregorio, additional, Ciceri, Fabio, additional, Chowdhury, Fazle Rabbi, additional, Chelysheva, Ekaterina, additional, Chauchet, Adrien, additional, Chai, Louis Yi Ann, additional, Ceesay, M. Mansour, additional, Busch, Elena, additional, Brehon, Mathias, additional, Borducchi, Davimar M.M., additional, Booth, Stephen, additional, Bologna, Serge, additional, Berg Venemyr, Caroline, additional, Bailén-Almorox, Rebeca, additional, Antoniadou, Anastasia, additional, Anastasopoulou, Amalia N., additional, and Altuntaş, Fevzi, additional
Published: 2024
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12. Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis

Author: Davis, Angharad G, Nightingale, Sam, Springer, Priscilla E, Solomons, Regan, Arenivas, Ana, Wilkinson, Robert J, Anderson, Suzanne T, Chow, Felicia C, Aarnoutse, Rob E, Anderson, Suzanne TB, Bahr, Nathan C, Bang, Nguyen D, Boulware, David R, Boyles, Tom, Brake, Lindsey HM te, Chandra, Satish, Cresswell, Fiona V, van Crevel, Reinout, Dian, Sofiati, Donovan, Joseph, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imran, Darma, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Jeejeebhoy, Byramee, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, Thwaites, Guy E, van Toorn, Ronald, Tucker, Elizabeth W, and Wasserman, Sean A
Subjects: Biomedical and Clinical Sciences, Health Sciences, Neurosciences, Brain Disorders, Behavioral and Social Science, Mental health, Good Health and Well Being, Tuberculous Meningitis International Research Consortium, Functional, Neurobehavioural, Neurocognitive, Neurodevelopmental, Psychiatric, Tuberculous Meningitis, Biomedical and clinical sciences, Health sciences
Abstract: In those who survive tuberculous meningitis (TBM), the long-term outcome is uncertain; individuals may suffer neurocognitive, functional and psychiatric impairment, which may significantly affect their ability to lead their lives as they did prior to their diagnosis of TBM. In children who survive, severe illness has occurred at a crucial timepoint in their development, which can lead to behavioural and cognitive delay. The extent and nature of this impairment is poorly understood, particularly in adults. This is in part due to a lack of observational studies in this area but also inconsistent inclusion of outcome measures which can quantify these deficits in clinical studies. This leads to a paucity of appropriate rehabilitative therapies available for these individuals and their caregivers, as well as burden at a socioeconomic level. In this review, we discuss what is known about neurocognitive impairment in TBM, draw on lessons learnt from other neurological infections and discuss currently available and emerging tools to evaluate function and cognition and their value in TBM. We make recommendations on which measures should be used at what timepoints to assess for impairment, with a view to optimising and standardising assessment of neurocognitive and functional impairment in TBM research.
Published: 2019

13. Establishing the cascade of care for patients with tuberculous meningitis

Author: Imran, Darma, Hill, Philip C, McKnight, Jacob, van Crevel, Reinout, Aarnoutse, Rob E, Anderson, Suzanne TB, Bahr, Nathan C, Bang, Nguyen D, Boulware, David R, Boyles, Tom, Brake, Lindsey HM te, Chandra, Satish, Chow, Felicia C, Cresswell, Fiona V, Davis, Angharad G, Dian, Sofiati, Donovan, Joseph, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Jeejeebhoy, Byramee, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, Thwaites, Guy E, van Toorn, Ronald, Tucker, Elizabeth W, Wasserman, Sean A, and Wilkinson, Robert J
Subjects: Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Infectious Diseases, Health Services, Tuberculosis, HIV/AIDS, Clinical Research, Rare Diseases, 8.1 Organisation and delivery of services, Health and social care services research, Infection, Good Health and Well Being, Tuberculous Meningitis International Research Consortium, cascade of care, health systems, meningitis, patient pathway analysis, tuberculosis, Biomedical and clinical sciences, Health sciences
Abstract: Meningitis is a relatively rare form of tuberculosis, but it carries a high mortality rate, reaching 50% in some settings, with higher rates among patients with HIV co-infection and those with drug-resistant disease. Most studies of tuberculosis meningitis (TBM) tend to focus on better diagnosis, drug treatment and supportive care for patients in hospital. However, there is significant variability in mortality between settings, which may be due to specific variation in the availability and quality of health care services, both prior to, during, and after hospitalization. Such variations have not been studied thoroughly, and we therefore present a theoretical framework that may help to identify where efforts should be focused in providing optimal services for TBM patients. As a first step, we propose an adjusted cascade of care for TBM and patient pathway studies that might help identify factors that account for losses and delays across the cascade. Many of the possible gaps in the TBM cascade are related to health systems factors; we have selected nine domains and provide relevant examples of systems factors for TBM for each of these domains that could be the basis for a health needs assessment to address such gaps. Finally, we suggest some immediate action that could be taken to help make improvements in services. Our theoretical framework will hopefully lead to more health system research and improved care for patients suffering from this most dangerous form of tuberculosis.
Published: 2019

14. Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: A systematic review and diagnostic test accuracy meta-analysis

Author: Stadelman, Anna M., Ssebambulidde, Kenneth, Buller, Alexandria, Tugume, Lillian, Yuquimpo, Kyle, Bakker, Caitlin J., Boulware, David R., and Bahr, Nathan C.
Published: 2022
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15. Low incidence of invasive fungal infection and risk factors in a large observational cohort of patients initiating tumor necrosis factor-alpha inhibitors for dermatologic conditions.

Author: Hennessee, Ian, Benedict, Kaitlin, Bahr, Nathan C., Lipner, Shari R., and Gold, Jeremy A.W.
Published: 2024
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16. Persistent fever after coronavirus disease 2019 in liver/kidney transplant recipient

Author: Mullis, Caroline E., primary, Heldman, Madeleine, additional, Bahr, Nathan C., additional, Minamoto, Grace Y., additional, Puius, Yoram A., additional, and Malinis, Maricar, additional
Published: 2024
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17. Infectious Diseases Physician Management of Cryptococcal Meningitis in North America – Is Single High-Dose Liposomal Amphotericin B Being Used?

Author: Bahr, Nathan C, primary, Beekmann, Susan E, additional, Polgreen, Philip M, additional, Walker, Jeremey B, additional, Spec, Andrej, additional, Boulware, David R, additional, and Baddley, John W, additional
Published: 2024
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18. Cutaneous infection with Mycobacterium fortuitum after subcutaneous injection of human chorionic gonadotropin

Author: Neill, Brett C, Bahr, Nathan C, Bryan, Zachary, and Aires, Daniel J
Subjects: Mycobacterium infections, nontuberculosis, skin diseases, infectious, human chorionic gonadotropin, drug effects, Mycobacterium fortuitum
Abstract: Background: Weight loss clinics are common in the United States. Unfortunately, some offer dubious weight loss methods such as self-administered human chorionic gonadotropin (HCG) injections. HCG products are unregulated, yet, widely available. Infection is among the risks potentially associated with this treatment. We report a case of skin infection caused by Mycobacterium fortuitum after HCGinjection.Case Presentation: A 51-year-old woman with a history of hypogammaglobulinemia presented with an eight week history of a tender abdominal lesion. The lesion was at the site of a previous HCG injection.Acid-fast bacilli (AFB) culture grew Mycobacterium fortuitum. Based on the organism’s susceptibility profile, sulfamethoxazole-trimethoprim 800-160mg and ciprofloxacin 500 mg were both prescribed. The case was referred to the Missouri Department of Health. Based on clinical progress treatment was continued for a total of six months.Conclusions: This case illustrates the potential for cutaneous infection by Mycobacterium fortuitum and other rapidly growing mycobacteria after HCGinjections. Clinicians should maintain a high index for suspicion for rapidly growing mycobacteria when evaluating persistent skin lesions at sites of trauma or skin puncture.
Published: 2017

19. Decoding the historical tale: COVID-19 impact on haematological malignancy patients-EPICOVIDEHA insights from 2020 to 2022

Author: Arellano-Orden, Elena [0000-0003-0581-8947], Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano-Orden, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, van Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola, Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-Vukičević, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S, Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques de Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, Arellano-Orden, Elena [0000-0003-0581-8947], Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano-Orden, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, van Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola, Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-Vukičević, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S, Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques de Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio
Abstract: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced.
Published: 2024

20. Low incidence of invasive fungal infections in a large observational cohort of patients initiating IL-17 or IL-23 inhibitor therapy, United States, 2016-2022.

Author: Bahr, Nathan C., Benedict, Kaitlin, Toda, Mitsuru, Gold, Jeremy A.W., and Lipner, Shari R.
Published: 2024
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21. Diagnostic accuracy of a novel lateral flow assay for histoplasmosis.

Author: Burrows, Megan, Miller, Janice, Liesman, Rachael M, and Bahr, Nathan C
Abstract: Antigen testing is an important diagnostic tool for histoplasmosis but has limited availability globally. We evaluated the OIDx urine lateral flow antigen assay among 204 persons suspected to have histoplasmosis. Among patients with proven histoplasmosis, sensitivity was 33.3% (3/9, 95% CI 7.5%–70.1%) and specificity 80.5% (157/195, 95% CI 74.3%–85.8%). The MiraVista urine antigen test had better specificity (96.9%) and equal sensitivity. The OIDx test demonstrated 33.3% (3/9) positive agreement and 84.0% (163/194) negative agreement with the MiraVista test. These results should be considered in the context of our low HIV prevalence population with a mixture of pulmonary and disseminated disease. [ABSTRACT FROM AUTHOR]
Published: 2024
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22. Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis

Author: Pormohammad, Ali, Ghorbani, Saied, Baradaran, Behzad, Khatami, Alireza, J. Turner, Raymond, Mansournia, Mohammad Ali, Kyriacou, Demetrios N., Idrovo, Juan-Pablo, and Bahr, Nathan C.
Published: 2020
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23. Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

Author: Cresswell, Fiona V, Tugume, Lillian, Bahr, Nathan C, Kwizera, Richard, Bangdiwala, Ananta S, Musubire, Abdu K, Rutakingirwa, Morris, Kagimu, Enock, Nuwagira, Edwin, Mpoza, Edward, Rhein, Joshua, Williams, Darlisha A, Muzoora, Conrad, Grint, Daniel, Elliott, Alison M, Meya, David B, and Boulware, David R
Published: 2020
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24. GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last

Author: Bahr, Nathan C, Marais, Suzaan, Caws, Maxine, van Crevel, Reinout, Wilkinson, Robert J, Tyagi, Jaya S, Thwaites, Guy E, Boulware, David R, Aarnoutse, Rob, Van Crevel, Reinout, van Laarhoven, Aarjan, Dian, Sofiati, Cronan, Mark R, Tobin, David, Dooley, Kelly, Dunstan, Sarah, Feng, Guo-dong, Shi, Xiaodan, Wang, Ting, Figaji, Anthony, McIlleron, Helen, Meintjes, Graeme, Rohlwink, Ursula, Rizal, Ahmad, Ruslami, Rovina, Garg, Ravindra K, Gupta, Mudit, Gupta, Rakesh K, Gupta, Sneha, Savic, Rada, Heemskerk, Anna D, Nguyễn, Thương Thụy Thương, Nguyễn, Mai Thị Hoàng, Srinivasan, Vijay, Thwaites, Guy, Trần, Trâm Thị Bích, Trần, Thịnh Thi Vân, Trần, Anh Thi Ngọc, Võ, Trang Hồng Yêng, Wolbers, Marcel, Kalita, Jayantee, Misra, Usha K, Lai, Rachel, Marais, Ben J, Trinh, Mai Quỳnh, Nguyễn, Bằng Đức, Nguyễn, Yến Bích, Patel, Vinod, Pouplin, Thomas, Ramakrishnan, Lalita, Schoeman, Johan F, Solomons, Regan, Van Toorn, Ronald, Seddon, James, Shah, Javeed, and Visser, Douwe H
Subjects: Rare Diseases, Good Health and Well Being, DNA, Bacterial, Humans, Mycobacterium tuberculosis, Nucleic Acid Amplification Techniques, Tuberculosis, Meningeal, Tuberculous Meningitis International Research Consortium, diagnosis, guideline, meningitis, perspective, tuberculous, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract: Tuberculous meningitis (TBM) is the most severe form of tuberculous with substantial mortality. In May 2015, 54 researchers from 10 countries met in Da Lat, Vietnam, to discuss advances in TBM. Among the attendees were researchers involved in pivotal studies on the use of Xpert MTB/Rif for TBM diagnosis. Attendees discussed the 2014 World Health Organization strong recommendation favoring the use of Xpert "in preference to conventional microscopy and culture as the initial diagnostic test for cerebrospinal fluid (CSF) if the sample volume is low or if additional specimens cannot be obtained to make a quick diagnosis." Attendees were concerned that the limitations of Xpert testing for TBM are not emphasized. Clear guidance is needed for the investigational pathway for TBM, including recommendations on the diagnostic package of investigations, which does not stop with Xpert testing. Second, emphasis on the large CSF volumes (ideally 8-10 mL) needed for Xpert testing is required. Guidelines should also emphasize that TBM is a medical emergency and early treatment reduces mortality.
Published: 2016

25. 1506. Prevalence of Histoplasma Antigenuria among an outpatient Advanced HIV cohort in Kampala,Uganda

Author: Sekar, Preethiya, primary, Nalintya, Elizabeth, additional, Kwizera, Richard, additional, Mukashyaka, Claudine, additional, Niyonzima, Godfrey, additional, Namakula, Olive Loryndah, additional, Nerima, Patricia, additional, Fieberg, Ann, additional, Dai, Biyue, additional, Bahr, Nathan C, additional, Ellis, Jayne, additional, Meya, David, additional, Boulware, David R, additional, and Rajasingham, Radha, additional
Published: 2023
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26. 1490. Predictors of Early Mortality in HIV-associated Tuberculous Meningitis

Author: Kagimu, Enock, primary, Bangdiwala, Ananta, additional, Kasibante, John, additional, Kabahubya, Mable, additional, Gakuru, Jane, additional, Timothy, Mugabi, additional, Namombwe, Suzan, additional, Kimuda, Sarah, additional, Kasozi, Derrick, additional, Rutakingirwa, Morris K, additional, Ssebambulidde, Kenneth, additional, Tugume, Lillian, additional, Nuwagira, Edwin, additional, Okurut, Samuel, additional, Nsangi, Laura, additional, Atukunda, Mucunguzi, additional, Ellis, Jayne P, additional, Williams, Darlisha A, additional, Musubire, Abdu Kisekka, additional, Boulware, David R, additional, Meya, David, additional, Bahr, Nathan C, additional, and Cresswell, Fiona V, additional
Published: 2023
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27. 2700. Reducing the Dose of Mycophenolate in Solid Organ Transplant Recipients Diagnosed with SARS-CoV-2 Infection Increases the Risk of Severe COVID-19

Author: Gillcrist, Marion, primary, Waller, Stephen, additional, Taylor, Ryan M, additional, Bahr, Nathan C, additional, Cibrik, Diane M, additional, Shah, Zubair, additional, and Eid, Albert, additional
Published: 2023
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28. 2705. Predictors of Severe COVID-19 among Solid Organ Transplant Recipients

Author: Gillcrist, Marion, primary, Waller, Stephen, additional, Taylor, Ryan M, additional, Bahr, Nathan C, additional, Cibrik, Diane M, additional, Shah, Zubair, additional, Montgomery, Robert, additional, and Eid, Albert, additional
Published: 2023
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29. Re-drawing the Maps for Endemic Mycoses

Author: Ashraf, Nida, Kubat, Ryan C., Poplin, Victoria, Adenis, Antoine A., Denning, David W., Wright, Laura, McCotter, Orion, Schwartz, Ilan S., Jackson, Brendan R., Chiller, Tom, and Bahr, Nathan C.
Published: 2020
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30. Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

Author: Rhein, Joshua, Huppler Hullsiek, Kathy, Tugume, Lillian, Nuwagira, Edwin, Mpoza, Edward, Evans, Emily E, Kiggundu, Reuben, Pastick, Katelyn A, Ssebambulidde, Kenneth, Akampurira, Andrew, Williams, Darlisha A, Bangdiwala, Ananta S, Abassi, Mahsa, Musubire, Abdu K, Nicol, Melanie R, Muzoora, Conrad, Meya, David B, Boulware, David R, Ndyetukira, Jane Francis, Ahimbisibwe, Cynthia, Kugonza, Florence, Namuju, Carolyne, Sadiq, Alisat, Namudde, Alice, Mwesigye, James, Tadeo, Kiiza K, Kirumira, Paul, Okirwoth, Michael, Luggya, Tonny, Kaboggoza, Julian, Laker, Eva, Atwine, Leo, Muganzi, Davis, Walukaga, Stewart, Jawed, Bilal, Merry, Matthew, Stadelman, Anna, Stephens, Nicole, Flynn, Andrew G, Fujita, Ayako W, Kwizera, Richard, Mukaremera, Liliane, Lofgren, Sarah M, Cresswell, Fiona V, Morawski, Bozena M, Bahr, Nathan C, and Nielsen, Kirsten
Published: 2019
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31. Seroprevalence of Histoplasmosis in Somali, Burmese, and Hmong Refugees Residing in Thailand and Kenya

Author: Bahr, Nathan C., Lee, Deborah, Stauffer, William M., Durkin, Michelle, Cetron, Martin S., Wheat, L. Joseph, and Boulware, David R.
Published: 2018

32. Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

Author: Williams, Darlisha A, Taseera, Kabanda, Nyehangane, Dan, Ivan, Mugisha, Orikiriza, Patrick, Rhein, Joshua, Hullsiek, Kathy Huppler, Musubire, Abdu, Pastick, Katelyn, Nabeta, Pamela, Mwesigye, James, Rajasingham, Radha, Bahr, Nathan C, Nuwagira, Edwin, Evans, Emily E, Cresswell, Fiona V, Bystrom, Philip V, Byamukama, Adolf, Bridge, Sarah C, Bangdiwala, Ananta S, Meya, David B, Denkinger, Claudia M, Muzoora, Conrad, and Boulware, David R
Published: 2018
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33. Eosinophilic Meningitis Due to Infection With Paragonimus kellicotti

Author: Bahr, Nathan C., Trotman, Robin L., Samman, Hala, Jung, Richard S., Rosterman, Lee R., Weil, Gary J., and Hinthorn, Daniel R.
Published: 2017

34. Differences in Immunologic Factors Among Patients Presenting with Altered Mental Status During Cryptococcal Meningitis

Author: COAT and ASTRO-CM Trial Teams, Lofgren, Sarah, Hullsiek, Kathy H., Morawski, Bozena M., Nabeta, Henry W., Kiggundu, Reuben, Taseera, Kabanda, Musubire, Abdu, Schutz, Charlotte, Abassi, Mahsa, Bahr, Nathan C., Tugume, Lillian, Muzoora, Conrad, Williams, Darlisha A., Rolfes, Melissa A., Velamakanni, Sruti S., Rajasingham, Radha, Meintjes, Graeme, Rhein, Joshua, Meya, David B., and Boulware, David R.
Published: 2017

35. The Current and Future States of Diagnostic Tests for Histoplasmosis with a Focus on People with HIV and Disseminated Histoplasmosis

Author: Villareal, Kenneth, primary, Price, Austin, additional, Pasqualotto, Alessandro C., additional, and Bahr, Nathan C., additional
Published: 2023
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36. Prevalence of Histoplasma Antigenuria among Outpatient Cohort with Advanced HIV in Kampala, Uganda

Author: Sekar, Preethiya, primary, Nalintya, Elizabeth, additional, Kwizera, Richard, additional, Mukashyaka, Claudine, additional, Niyonzima, Godfrey, additional, Namakula, Loryndah Olive, additional, Nerima, Patricia, additional, Fieberg, Ann, additional, Dai, Biyue, additional, Ellis, Jayne, additional, Boulware, David R., additional, Meya, David B., additional, Bahr, Nathan C., additional, and Rajasingham, Radha, additional
Published: 2023
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37. Single High-dose of Liposomal Amphotericin B in HIV/AIDS-related Disseminated Histoplasmosis: a Randomized Trial

Author: Pasqualotto, Alessandro C, primary, Dalla Lana, Daiane, additional, Godoy, Cassia S M, additional, Leitão, Terezinha do Menino Jesus Silva, additional, Bay, Monica B, additional, Damasceno, Lisandra Serra, additional, Soares, Renata B A, additional, Kist, Roger, additional, Silva, Larissa R, additional, Wiltgen, Denusa, additional, Melo, Marineide, additional, Guimarães, Taiguara F, additional, Guimarães, Marilia R, additional, Vechi, Hareton T, additional, de Mesquita, Jacó R L, additional, Monteiro, Gloria Regina de G, additional, Adenis, Antoine, additional, Bahr, Nathan C, additional, Spec, Andrej, additional, Boulware, David R, additional, Israelski, Dennis, additional, Chiller, Tom, additional, and Falci, Diego R, additional
Published: 2023
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38. Advanced HIV disease: A review of diagnostic and prophylactic strategies

Author: Lehman, Alice, primary, Ellis, Jayne, additional, Nalintya, Elizabeth, additional, Bahr, Nathan C., additional, Loyse, Angela, additional, and Rajasingham, Radha, additional
Published: 2023
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39. Factors Associated With Adherence to First-line Antiviral Therapy Among Commercially Insured Patients With Chronic Hepatitis B

Author: Alpern, Jonathan D, primary, Joo, Heesoo, additional, Bahr, Nathan C, additional, and Leventhal, Thomas M, additional
Published: 2023
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40. COVID-19 in adult acute myeloid leukemia patients:a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)

Author: Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Da Silva, Maria Gomes, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M., Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jens, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andreas, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C., El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nunes, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Da Silva, Maria Gomes, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M., Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jens, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andreas, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C., El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nunes, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio
Abstract: Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.
Published: 2023

41. Outcome of COVID-19 in allogeneic stem cell transplant recipients:Results from the EPICOVIDEHA registry

Author: Busca, Alessandro, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Seval, Guldane Cengiz, Van Doesum, Jaap, De Jonge, Nick, Bahr, Nathan C., Maertens, Johan, Meletiadis, Joseph, Fracchiolla, Nicola S., Weinbergerová, Barbora, Verga, Luisa, Ráčil, Zdeněk, Jiménez, Moraima, Glenthøj, Andreas, Blennow, Ola, Tanase, Alina Daniela, Schönlein, Martin, Prezioso, Lucia, Khanna, Nina, Duarte, Rafael F., Žák, Pavel, Nucci, Marcio, Machado, Marina, Kulasekararaj, Austin, Espigado, Ildefonso, De Kort, Elizabeth, Ribera-Santa Susana, José María, Marchetti, Monia, Magliano, Gabriele, Falces-Romero, Iker, Ilhan, Osman, Ammatuna, Emanuele, Zompi, Sofia, Tsirigotis, Panagiotis, Antoniadou, Anastasia, Zambrotta, Giovanni Paolo Maria, Nordlander, Anna, Karlsson, Linda Katharina, Hanakova, Michaela, Dragonetti, Giulia, Cabirta, Alba, Berg Venemyr, Caroline, Gräfe, Stefanie, Van Praet, Jens, Tragiannidis, Athanasios, Petzer, Verena, López-García, Alberto, Itri, Federico, Groh, Ana, Gavriilaki, Eleni, Dargenio, Michelina, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, Busca, Alessandro, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Seval, Guldane Cengiz, Van Doesum, Jaap, De Jonge, Nick, Bahr, Nathan C., Maertens, Johan, Meletiadis, Joseph, Fracchiolla, Nicola S., Weinbergerová, Barbora, Verga, Luisa, Ráčil, Zdeněk, Jiménez, Moraima, Glenthøj, Andreas, Blennow, Ola, Tanase, Alina Daniela, Schönlein, Martin, Prezioso, Lucia, Khanna, Nina, Duarte, Rafael F., Žák, Pavel, Nucci, Marcio, Machado, Marina, Kulasekararaj, Austin, Espigado, Ildefonso, De Kort, Elizabeth, Ribera-Santa Susana, José María, Marchetti, Monia, Magliano, Gabriele, Falces-Romero, Iker, Ilhan, Osman, Ammatuna, Emanuele, Zompi, Sofia, Tsirigotis, Panagiotis, Antoniadou, Anastasia, Zambrotta, Giovanni Paolo Maria, Nordlander, Anna, Karlsson, Linda Katharina, Hanakova, Michaela, Dragonetti, Giulia, Cabirta, Alba, Berg Venemyr, Caroline, Gräfe, Stefanie, Van Praet, Jens, Tragiannidis, Athanasios, Petzer, Verena, López-García, Alberto, Itri, Federico, Groh, Ana, Gavriilaki, Eleni, Dargenio, Michelina, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio
Abstract: Background: The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT. Methods: This multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022. Results: The median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53). Conclusions: Mortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.
Published: 2023

42. COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)

Author: Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Toma, Da Silva, Maria Gome, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M, Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S, Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jen, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C, El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nune, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A, Pagano, Livio, Pagano, Livio (ORCID:0000-0001-8287-928X), Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Toma, Da Silva, Maria Gome, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M, Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S, Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jen, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C, El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nune, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A, Pagano, Livio, and Pagano, Livio (ORCID:0000-0001-8287-928X)
Abstract: Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.
Published: 2023

43. COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

Author: Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio
Abstract: Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed (80%; p<0.001). Overall survival in patients with COVID-19 diagnosis between January 2020 and August 2020 was significantly lower than those who were diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs 60% vs 61.9%, respectively; p=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.
Published: 2023

44. Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry

Author: Gilead Sciences, Busca, Alessandro, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Cengiz-Seval, Guldane, Doesum, Jaap van, Jonge, Nick de, Bahr, Nathan C., Maertens, Johan, Meletiadis, Joseph, Fracchiolla, Nicola S., Weinbergerová, Barbora, Verga, Luisa, Ráčil, Zdeněk, Jiménez, Moraima, Glenthøj, Andreas, Blennow, Ola, Tanase, Alina Daniela, Schönlein, Martin, Prezioso, Lucia, Khanna, Nina, Duarte, Rafael F., Žák, Pavel, Nucci, Marcio, Machado, Marina, Kulasekararaj, Austin, Espigado, Ildefonso, Kort, Elizabeth de, Ribera-Santa Susana, José-María, Marchetti, Monia, Magliano, Gabriele, Falces-Romero, Iker, Ilhan, Osman, Ammatuna, Emanuele, Zompi, Sofia, Tsirigotis, Panagiotis, Antoniadou, Anastasia, Zambrotta, Giovanni Paolo Maria, Nordlander, Anna, Karlsson, Linda Katharina, Hanakova, Michaela, Dragonetti, Giulia, Cabirta, Alba, Berg Venemyr, Caroline, Gräfe, Stefanie, Praet, Jens van, Tragiannidis, Athanasios, Petzer, Verena, López-García, Alberto, Itri, Federico, Groh, Ana, Gavriilaki, Eleni, Dargenio, Michelina, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, EPICOVIDEHA Consortium, Gilead Sciences, Busca, Alessandro, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Cengiz-Seval, Guldane, Doesum, Jaap van, Jonge, Nick de, Bahr, Nathan C., Maertens, Johan, Meletiadis, Joseph, Fracchiolla, Nicola S., Weinbergerová, Barbora, Verga, Luisa, Ráčil, Zdeněk, Jiménez, Moraima, Glenthøj, Andreas, Blennow, Ola, Tanase, Alina Daniela, Schönlein, Martin, Prezioso, Lucia, Khanna, Nina, Duarte, Rafael F., Žák, Pavel, Nucci, Marcio, Machado, Marina, Kulasekararaj, Austin, Espigado, Ildefonso, Kort, Elizabeth de, Ribera-Santa Susana, José-María, Marchetti, Monia, Magliano, Gabriele, Falces-Romero, Iker, Ilhan, Osman, Ammatuna, Emanuele, Zompi, Sofia, Tsirigotis, Panagiotis, Antoniadou, Anastasia, Zambrotta, Giovanni Paolo Maria, Nordlander, Anna, Karlsson, Linda Katharina, Hanakova, Michaela, Dragonetti, Giulia, Cabirta, Alba, Berg Venemyr, Caroline, Gräfe, Stefanie, Praet, Jens van, Tragiannidis, Athanasios, Petzer, Verena, López-García, Alberto, Itri, Federico, Groh, Ana, Gavriilaki, Eleni, Dargenio, Michelina, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, and EPICOVIDEHA Consortium
Abstract: Background: The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT. Methods: This multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022. Results: The median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53). Conclusions: Mortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.
Published: 2023

45. Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study

Author: Rhein, Joshua, Morawski, Bozena M, Hullsiek, Kathy Huppler, Nabeta, Henry W, Kiggundu, Reuben, Tugume, Lillian, Musubire, Abdu, Akampurira, Andrew, Smith, Kyle D, Alhadab, Ali, Williams, Darlisha A, Abassi, Mahsa, Bahr, Nathan C, Velamakanni, Sruti S, Fisher, James, Nielsen, Kirsten, Meya, David B, and Boulware, David R
Published: 2016
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46. Histoplasmosis

Author: Wheat, Lawrence J., Azar, Marwan M., Bahr, Nathan C., Spec, Andrej, Relich, Ryan F., and Hage, Chadi
Published: 2016
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47. Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda

Author: Rhein, Joshua, Bahr, Nathan C., Hemmert, Andrew C., Cloud, Joann L., Bellamkonda, Satya, Oswald, Cody, Lo, Eric, Nabeta, Henry, Kiggundu, Reuben, Akampurira, Andrew, Musubire, Abdu, Williams, Darlisha A., Meya, David B., and Boulware, David R.
Published: 2016
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48. GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last

Author: Tuberculous Meningitis International Research Consortium, Bahr, Nathan C., Marais, Suzaan, Caws, Maxine, van Crevel, Reinout, Wilkinson, Robert J., Tyagi, Jaya S., Thwaites, Guy E., and Boulware, David R.
Published: 2016

49. Single High Dose of Liposomal Amphotericin B in Human Immunodeficiency Virus/AIDS-Related Disseminated Histoplasmosis: A Randomized Trial.

Author: Pasqualotto, Alessandro C, Lana, Daiane Dalla, Godoy, Cassia S M, Leitão, Terezinha do Menino Jesus Silva, Bay, Monica B, Damasceno, Lisandra Serra, Soares, Renata B A, Kist, Roger, Silva, Larissa R, Wiltgen, Denusa, Melo, Marineide, Guimarães, Taiguara F, Guimarães, Marilia R, Vechi, Hareton T, Mesquita, Jacó R L de, Monteiro, Gloria Regina de G, Adenis, Antoine, Bahr, Nathan C, Spec, Andrej, and Boulware, David R
Subjects: HIV infection complications, DRUG efficacy, HIV-positive persons, RESEARCH, AMPHOTERICIN B, RANDOMIZED controlled trials, CD4 lymphocyte count, DESCRIPTIVE statistics, SURVIVAL analysis (Biometry), DOSE-effect relationship in pharmacology, HISTOPLASMOSIS, STATISTICAL sampling, AIDS, AIDS patients, OVERALL survival, LONGITUDINAL method, DISEASE complications, EVALUATION, SYMPTOMS
Abstract: Background Histoplasmosis is a major AIDS-defining illness in Latin America. Liposomal amphotericin B (L-AmB) is the drug of choice for treatment, but access is restricted due to the high drug and hospitalization costs of the conventional long regimens. Methods Prospective randomized multicenter open-label trial of 1- or 2-dose induction therapy with L-AmB versus control for disseminated histoplasmosis in AIDS, followed by oral itraconazole therapy. We randomized subjects to: (i) single dose 10 mg/kg of L-AmB; (ii) 10 mg/kg of L-AmB on D1, and 5 mg/kg of L-AmB on D3; (iii) 3 mg/kg of L-AmB daily for 2 weeks (control). The primary outcome was clinical response (resolution of fever and signs/symptoms attributable to histoplasmosis) at day 14. Results A total of 118 subjects were randomized, and median CD4+ counts, and clinical presentations were similar between arms. Infusion-related toxicity, kidney toxicity at multiple time-points, and frequency of anemia, hypokalemia, hypomagnesemia, and liver toxicity were similar. Day 14 clinical response was 84% for single-dose L-AmB, 69% 2-dose L-AmB, and 74% for control arm (P =.69). Overall survival on D14 was 89.0% (34/38) for single-dose L-AmB, 78.0% (29/37) for 2-dose L-AmB, and 92.1% (35/38) for control arm (P =.82). Conclusions One day induction therapy with 10 mg/kg of L-AmB in AIDS-related histoplasmosis was safe. Although clinical response may be non-inferior to standard L-AmB therapy, a confirmatory phase III clinical trial is needed. A single induction dose would markedly reduce drug-acquisition costs (>4-fold) and markedly shorten and simplify treatment, which are key points in terms of increased access. [ABSTRACT FROM AUTHOR]
Published: 2023
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50. Pneumocystis jirovecii infections among COVID-19 Patients: A Case Series and Literature Review

Author: Amstutz, Paul, primary, Bahr, Nathan C, additional, Snyder, Karen, additional, and Shoemaker, D Matthew, additional
Published: 2023
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