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Limitations inherent to existing statistical distributions in capturing the complexities of real-world data often necessitate the development of novel models. This paper introduces the new exponential generalized inverse generalized Weibull (NEGIGW) distribution. The NEGIGW distribution boasts significant flexibility with symmetrical and asymmetrical shapes, allowing its hazard rate function to be adapted to many failure patterns observed in various fields such as medicine, biology, and engineering. Some statistical properties of the NEGIGW distribution, such as moments, quantile function, and Renyi entropy, are studied. Three methods are used for parameter estimation, including maximum likelihood, maximum product of spacing, and percentile methods. The performance of the estimation methods is evaluated via Monte Carlo simulations. The NEGIGW distribution excels in its ability to fit real-world data accurately. Five medical and engineering datasets are applied to demonstrate the superior fit of NEGIGW distribution compared to competing models. This compelling evidence suggests that the NEGIGW distribution is promising for lifetime data analysis and reliability assessments across different disciplines. [ABSTRACT FROM AUTHOR]

This paper introduces a novel alpha power exponentiated Weibull-Pareto distribution based on the alpha power transformation. We derive several properties of the new distribution, including moments, quantile function, mean residual life, mean waiting time, and order statistics. Estimating model parameters is performed using the method of maximum likelihood. Then, for the purpose of evaluating the effectiveness of the estimates, we conduct some simulation studies. Finally, we demonstrate the superiority of this new model by analyzing three real-life data sets. [ABSTRACT FROM AUTHOR]

In the process of identifying potential anticancer agents, the ability of a new agent is tested for cytotoxic activity against a panel of standard cancer cell lines. The National Cancer Institute (NCI) present the cytotoxic profile for each agent as a set of estimates of the dose required to inhibit the growth of each cell line. The NCI estimates are obtained from a linear interpolation method applied to the dose-response curves. In this paper non-linear fits are proposed as an alternative to interpolation. This is illustrated with data from two agents recently submitted to NCI for potential anticancer activity. Fitting of individual non-linear curves proved difficult, but a non-linear mixed model applied to the full set of cell lines overcame most of the problems. Two non-linear functional forms were fitted using random effect models by both maximum likelihood and a full Bayesian approach. Model-based toxicity estimates have some advantages over those obtained from interpolation. They provide standard errors for toxicity estimates and other derived quantities, allow model comparisons. Examples of each are illustrated. Copyright © 2005 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]