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887 results on '"Baeyens, W."'

2. Internal exposure of Flemish teenagers to environmental pollutants: Results of the Flemish Environment and Health Study 2016–2020 (FLEHS IV)

Author

Schoeters, G., Verheyen, V.J., Colles, A., Remy, S., Martin, L. Rodriguez, Govarts, E., Nelen, V., Den Hond, E., De Decker, A., Franken, C., Loots, I., Coertjens, D., Morrens, B., Bastiaensen, M., Gys, C., Malarvannan, G., Covaci, A., Nawrot, T., De Henauw, S., Bellemans, M., Leermakers, M., Van Larebeke, N., Baeyens, W., Jacobs, G., Voorspoels, S., Nielsen, F., and Bruckers, L.

Published
2022
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15. The Impact of Computer Supported Collaborative Learning on Internship Outcomes of Pharmacy Students

Author

Timmers, S., Valcke, M., de Mil, K., and Baeyens, W. R. G.

Abstract

This article focuses on an evaluation of the impact of an innovative instructional design of internships in view of a new integrated pharmaceutical curriculum. A key innovative element was the implementation of a computer-supported collaborative learning environment. Students were, as part of their formal curriculum, expected to work in a systematic and collaborative way in discussing and solving real-life cases. Students in the role condition were assigned specific roles. The cases were an additional critical variable in the study. The results of the study demonstrate that both independent variables (role assignment and cases) have a significant impact on levels of knowledge construction and, especially, on the attainment of objectives of the new integrated pharmaceutical curriculum. (Contains 2 tables and 3 figures.)

Published
2008
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21. Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: Optimization and analysis of human serum samples from adolescents of the Flemish Environment and Health Study (FLEHS II)

Author

Croes, K., Van Langenhove, K., Hond, E. Den, Bruckers, L., Colles, A., Koppen, G., Loots, I., Nelen, V., Schoeters, G., Nawrot, T., Van Larebeke, N., Denison, M.S., Vandermarken, T., Elskens, M., and Baeyens, W.

Published
2011
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37. Early-life exposure to multiple persistent organic pollutants and metals and birth weight: Pooled analysis in four Flemish birth cohorts

Author

Govarts, E., Portengen, L., Lambrechts, N., Bruckers, L., Den Hond, E., Covaci, A., Nelen, V., Nawrot, T.S., Loots, I., Sioen, I., Baeyens, W., Morrens, B., Schoeters, G., Vermeulen, R., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Vriendenkring VUB, Analytical, Environmental & Geo-Chemistry, Chemistry, Covaci, Adrian/0000-0003-0527-1136, IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
010504 meteorology & atmospheric sciences, Physiology, 010501 environmental sciences, 01 natural sciences, Persistent Organic Pollutants, chemistry.chemical_compound, Sociology, Pregnancy, POLYCHLORINATED-BIPHENYLS, Medicine, CORD BLOOD, lcsh:Environmental sciences, General Environmental Science, lcsh:GE1-350, OUTCOMES, Gestational age, Organochlorine compounds, Multipollutant models, Polychlorinated Biphenyls, VARIABLE SELECTION, Chemistry, Dichlorodiphenyldichloroethylene, Biomarker (medicine), Environmental Pollutants, Female, Risk assessment, Life Sciences & Biomedicine, AROMATIC-HYDROCARBONS, Dichlorodiphenyl Dichloroethylene, Birth weight, ENDOCRINE-DISRUPTING CHEMICALS, Environmental Sciences & Ecology, Pooled analysis, Linear regression, Humans, Biology, PRENATAL EXPOSURE, 0105 earth and related environmental sciences, Pollutant, Science & Technology, business.industry, Bayes Theorem, Hexachlorobenzene, chemistry, CADMIUM EXPOSURE, FETAL-GROWTH, Human medicine, business, Environmental Sciences
Abstract

Background and aims: Prenatal chemical exposure has frequently been associated with reduced fetal growth although results have been inconsistent. Most studies associate single pollutant exposure to this health outcome, even though this does not reflect real life situations as humans are exposed to many pollutants during their life time. The objective of this study is to investigate the association between prenatal exposure to a mixture of persistent environmental chemicals and birth weight using multipollutant models. Methods: We combined exposure biomarker data measured in cord blood samples of 1579 women from four Flemish birth cohorts collected over a 10 years' time period. The common set of available and detectable exposure measures in these cohorts are three polychlorinated biphenyls (PCB) congeners (138, 153 and 180), hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (p,p'-DDE) and the metals cadmium and lead. Multiple linear regression (MLR), Bayesian Information Criterion (BIC), penalized regression using minimax concave penalty (MCP) and Bayesian Adaptive Sampling (BAS) were applied to assess the influence of multiple pollutants in a single analysis on birth weight, adjusted for a priori selected covariates. Results: In the pooled dataset, a median (P25-P75) birth weight and gestational age of 3420 (3140-3700) grams and 39 (39-40) weeks was observed respectively. The median contaminant levels in cord blood were: 15.8, 26.5, 18.0, 16.9 and 91.5 ng/g lipid for PCB 138, PCB 153, PCB 180, HCB and p,p'-DDE, respectively, 0.075 mu g/L for cadmium and 9.7 mu g/L for lead. According to the applied statistical methods for multipollutant assessment, p,p'-DDE and PCB 180 were most consistently associated with birth weight. In addition, PCB 153 was selected when applying MCP and BAS. An inverse association with birth weight was found for the PCB congeners, while an increased birth weight was observed for elevated levels of p,p'-DDE. Conclusions: Assessing the health risk of combinations of exposure biomarkers reflects better real-world situations and thereby allows more effective risk assessment. Our results add to the existing evidence based on detrimental effects of PCBs on birth weight and indicate a possible increase in birth weight due to p,p'-DDE (while correcting for PCBs). The FLEHS studies were carried out by the Flemish Center of Expertise on Environment and Health. The studies of the Center were commissioned, financed and steered by the Ministry of the Flemish Community. NIRAS/ONDRAF (Belgian National Agency for Radioactive Waste and enriched Fissile Material), STORA (Study and Consultation Radioactive Waste Dessel) and MONA (Mols Overleg Nucleair Afval) financed the 3xG study. Govarts, E (corresponding author), Flemish Inst Technol Res VITO, Hlth, Boeretang 200, B-2400 Mol, Belgium. eva.govarts@vito.be

Published
2020
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