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17 results on '"Baer, Romain"'

1. Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

Author

Thibault, Benoit, Ramos‐Delgado, Fernanda, Pons‐Tostivint, Elvire, Therville, Nicole, Cintas, Celia, Arcucci, Silvia, Cassant‐Sourdy, Stephanie, Reyes‐Castellanos, Gabriela, Tosolini, Marie, Villard, Amelie V, Cayron, Coralie, Baer, Romain, Bertrand‐Michel, Justine, Pagan, Delphine, Ferreira Da Mota, Dina, Yan, Hongkai, Falcomatà, Chiara, Muscari, Fabrice, Bournet, Barbara, Delord, Jean‐Pierre, Aksoy, Ezra, Carrier, Alice, Cordelier, Pierre, Saur, Dieter, Basset, Celine, and Guillermet‐Guibert, Julie

Published
2021
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2. PI3Kα activity in PHGDH-low pancreatic epithelial cells limits tissue proliferative regeneration in cancer promoting conditions

Author

Cayron, Coralie, primary, Bozoglou, Dimitra, additional, Villard, Amelie V, additional, Reyes-Castellanos, Gabriella, additional, Therville, Nicole, additional, Baer, Romain, additional, Arcucci, Silvia, additional, Naud, Nathalie, additional, Tosolini, Marie, additional, Pont, Frederic, additional, Ferreira Da Mota, Dina, additional, Gueraud, Francoise, additional, Basset, Celine, additional, Carrier, Alice, additional, Pierre, Fabrice, additional, Thibault, Benoit, additional, Dufresne, Marlene, additional, and Guillermet-Guibert, Julie, additional

Published
2023
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4. eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer

Author

Müller, David, primary, Shin, Sauyeun, additional, Goullet de Rugy, Théo, additional, Samain, Rémi, additional, Baer, Romain, additional, Strehaiano, Manon, additional, Masvidal-Sanz, Laia, additional, Guillermet-Guibert, Julie, additional, Jean, Christine, additional, Tsukumo, Yoshinori, additional, Sonenberg, Nahum, additional, Marion, Frédéric, additional, Guilbaud, Nicolas, additional, Hoffmann, Jean-Sébastien, additional, Larsson, Ola, additional, Bousquet, Corinne, additional, Pyronnet, Stéphane, additional, and Martineau, Yvan, additional

Published
2019
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5. Translational control of DNA replication by 4E-BP1 in pancreatic cancer

Author

Müller, David, primary, Goullet de Rugy, Théo, additional, Shin, Sauyeun, additional, Samain, Rémi, additional, Baer, Romain, additional, Strehaiano, Manon, additional, Masvidal-Sanz, Laia, additional, Guillermet-Guibert, Julie, additional, Jean, Christine, additional, Tsukumo, Yoshinori, additional, Sonenberg, Nahum, additional, Marion, Frédéric, additional, Guilbaud, Nicolas, additional, Hoffman, Jean-Sébastien, additional, Larsson, Ola, additional, Bousquet, Corinne, additional, Pyronnet, Stéphane, additional, and Martineau, Yvan, additional

Published
2018
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7. Loss of 4E-BP1-mediated translational control favors DNA replication in pancreatic cancer.

Author

Müller, David, primary, Goullet de Rugy, Théo, additional, Saamin, Rémi, additional, Shin, Sauyeun, additional, Baer, Romain, additional, Masvidal-Sanz, Laia, additional, Grimal, Fanny, additional, Avet-Loiseau, Hervé, additional, Guillermet-Guibert, Julie, additional, Tsukumo, Yoshinori, additional, Cassant-Sourdy, Stéphanie, additional, Jean, Christine, additional, Sonenberg, Nahum, additional, Hoffmann, Jean-Sébastien, additional, Larsson, Ola, additional, Bousquet, Corinne, additional, Pyronnet, Stéphane, additional, and Martineau, Yvan, additional

Published
2017
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9. Loss of p27/Kip1 promotes metaplasia in the pancreas via the regulation of Sox9 expression

Author

Jeannot, Pauline, Callot, Caroline, Baer, Romain, Duquesnes, Nicolas, Guerra, Carmen, Guillermet-Guibert, Julie, Bachs Valldeneu, Oriol, Besson, Arnaud, and Universitat de Barcelona

Subjects
Mice, Knockout, Metaplasia, p27Kip1, CDK, SOX9 Transcription Factor, Enzyme inhibitors, Cell cycle, Cicle cel·lular, Pàncrees, Proteïnes quinases, Mice, Cell Transformation, Neoplastic, HEK293 Cells, Inhibidors enzimàtics, Protein kinases, Cell Line, Tumor, Animals, Humans, cell cycle, pancreas, Pancreas, Cyclin-Dependent Kinase Inhibitor p27, Research Paper, HeLa Cells, Signal Transduction
Abstract

p27Kip1 (p27) is a negative regulator of proliferation and a tumor suppressor via the inhibition of cyclin-CDK activity in the nucleus. p27 is also involved in the regulation of other cellular processes, including transcription by acting as a transcriptional co-repressor. Loss of p27 expression is frequently observed in pancreatic adenocarcinomas in human and is associated with decreased patient survival. Similarly, in a mouse model of K-Ras-driven pancreatic cancer, loss of p27 accelerates tumor development and shortens survival, suggesting an important role for p27 in pancreatic tumorigenesis. Here, we sought to determine how p27 might contribute to early events leading to tumor development in the pancreas. We found that K-Ras activation in the pancreas causes p27 mislocalization at pre-neoplastic stages. Moreover, loss of p27 or expression of a mutant p27 that does not bind cyclin-CDKs causes the mislocalization of several acinar polarity markers associated with metaplasia and induces the nuclear expression of Sox9 and Pdx1 two transcription factors involved in acinar-to-ductal metaplasia. Finally, we found that p27 directly represses transcription of Sox9, but not that of Pdx1. Thus, our results suggest that K-Ras activation, the earliest known event in pancreatic carcinogenesis, may cause loss of nuclear p27 expression which results in derepression of Sox9, triggering reprogrammation of acinar cells and metaplasia.

Published
2015

10. Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models

Author

Ligat, Laetitia, primary, Saint-Laurent, Nathalie, additional, El-Mrani, Aïcha, additional, Gigoux, Véronique, additional, Al Saati, Talal, additional, Tomasini, Richard, additional, Nigri, Jérémy, additional, Dejean, Sébastien, additional, Pont, Frédéric, additional, Baer, Romain, additional, Guillermet-Guibert, Julie, additional, Cordelier, Pierre, additional, Lopez, Frédéric, additional, and Dufresne, Marlène, additional

Published
2015
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13. Translational regulation of exocrine cell function and survival by ATF4-dependent expression of 4E-BP1

Author

Pyronnet, Stéphane, primary, Lasfargues, Charline, additional, Martineau, Yvan, additional, Müller, David, additional, Hess, David A., additional, DiRenzo, Daniel, additional, Khoutorsky, Arkady, additional, Baer, Romain, additional, Guillermet-Guibert, Julie, additional, Sonenberg, Nahum, additional, Konieczny, Stephen F., additional, and Bousquet, Corinne, additional

Published
2015
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14. Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α

Author

Baer, Romain, primary, Cintas, Célia, additional, Dufresne, Marlène, additional, Cassant-Sourdy, Stéphanie, additional, Schönhuber, Nina, additional, Planque, Laetitia, additional, Lulka, Hubert, additional, Couderc, Bettina, additional, Bousquet, Corinne, additional, Garmy-Susini, Barbara, additional, Vanhaesebroeck, Bart, additional, Pyronnet, Stéphane, additional, Saur, Dieter, additional, and Guillermet-Guibert, Julie, additional

Published
2014
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15. The non-mutated PI3Kalpha is a master signaling enzyme for pancreatic cancerogenesis

Author

Baer, Romain, primary, Dufresne, Marlène, additional, Cintas, Célia, additional, Cassant-Sourdy, Stéphanie, additional, Schönhuber, Nina, additional, Planque, Laetitia, additional, Lulka, Hubert, additional, Chalabi, Mounira, additional, Garmy-Susini, Barbara, additional, Bousquet, Corinne, additional, Saur, Dieter, additional, Vanhaesebroeck, Bart, additional, Pyronnet, Stéphane, additional, and Guillermet-Guibert, Julie, additional

Published
2014
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17. Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression.

Author

Jeannot P, Callot C, Baer R, Duquesnes N, Guerra C, Guillermet-Guibert J, Bachs O, and Besson A

Subjects
Animals, Cell Line, Tumor, Cell Transformation, Neoplastic metabolism, Cyclin-Dependent Kinase Inhibitor p27 genetics, Cyclin-Dependent Kinase Inhibitor p27 metabolism, HEK293 Cells, HeLa Cells, Humans, Metaplasia, Mice, Mice, Knockout, SOX9 Transcription Factor genetics, SOX9 Transcription Factor metabolism, Signal Transduction, Cyclin-Dependent Kinase Inhibitor p27 deficiency, Pancreas metabolism, Pancreas pathology, SOX9 Transcription Factor biosynthesis
Abstract

p27Kip1 (p27) is a negative regulator of proliferation and a tumor suppressor via the inhibition of cyclin-CDK activity in the nucleus. p27 is also involved in the regulation of other cellular processes, including transcription by acting as a transcriptional co-repressor. Loss of p27 expression is frequently observed in pancreatic adenocarcinomas in human and is associated with decreased patient survival. Similarly, in a mouse model of K-Ras-driven pancreatic cancer, loss of p27 accelerates tumor development and shortens survival, suggesting an important role for p27 in pancreatic tumorigenesis. Here, we sought to determine how p27 might contribute to early events leading to tumor development in the pancreas. We found that K-Ras activation in the pancreas causes p27 mislocalization at pre-neoplastic stages. Moreover, loss of p27 or expression of a mutant p27 that does not bind cyclin-CDKs causes the mislocalization of several acinar polarity markers associated with metaplasia and induces the nuclear expression of Sox9 and Pdx1 two transcription factors involved in acinar-to-ductal metaplasia. Finally, we found that p27 directly represses transcription of Sox9, but not that of Pdx1. Thus, our results suggest that K-Ras activation, the earliest known event in pancreatic carcinogenesis, may cause loss of nuclear p27 expression which results in derepression of Sox9, triggering reprogramming of acinar cells and metaplasia.

Published
2015
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