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24 results on '"Baek, Jee Yeon"'

2. Incidence and disease burden of autoimmune inflammatory rheumatic diseases after non‐pharmaceutical interventions in the COVID‐19 era: A nationwide observational study in Korea

Author

Shin, Je Hee, primary, Pyo, Jung Yoon, additional, Han, Minkyung, additional, Lee, Myeongjee, additional, Lim, Sung Min, additional, Baek, Jee Yeon, additional, Lee, Ji Young, additional, Kang, Ji‐Man, additional, Jung, InKyung, additional, and Ahn, Jong Gyun, additional

Published
2024
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18. Comparison of Clinical Characteristics and Risk Factors for Recurrence of Kikuchi–Fujimoto Disease Between Children and Adult

Author

Baek,Jee Yeon, Kang,Ji-Man, Lee,Ji Young, Lim,Sung Min, Ahn,Jong Gyun, Baek,Jee Yeon, Kang,Ji-Man, Lee,Ji Young, Lim,Sung Min, and Ahn,Jong Gyun

Abstract

Jee Yeon Baek,1 Ji-Man Kang,1,2 Ji Young Lee,1 Sung Min Lim,1 Jong Gyun Ahn1,2 1Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, Korea; 2Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, KoreaCorrespondence: Jong Gyun Ahn, Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea, Tel +82-2-2228-2057, Fax +82-2-393-9118, Email JGAHN@yuhs.acPurpose: Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limited disease, characterized by cervical lymphadenopathy and fever. Herein, we analyzed the differences in its clinical manifestations and risk factors for recurrence between children and adults.Patients and Methods: We retrospectively reviewed the medical records of patients diagnosed with KFD at a tertiary referral hospital between 2005 and 2019. Patients were divided into two groups based on their age: children (< 19 years) and adults (≥ 19 years).Results: During the 14-year study period, 127 patients were diagnosed with KFD. Among these, 34 (26.8%) were children and 93 (73.2%) were adults. The fever duration was longer and the frequency of myalgia was higher in adults than in children; however, no other significant symptomatic differences were noted between the two groups. Lymph node evaluation was mainly performed using ultrasound in children (61.8%) and computed tomography in adults (78.5%). Moreover, the frequency of antibiotic use was higher in children than in adults (76.5% vs 54.8%, P = 0.027). In adults, multivariable logistic regression analysis revealed anti-nuclear antibody (ANA) positivity (titer ≥ 1:80) as a risk factor for recurrence (odds ratio: 7.813; 95% confidence interval = 1.818– 33.333; P = 0.006).Conclusion: The clinical features of KFD in children and adults were similar; however, the preferred imaging study and frequency of antibioti

Published
2022

24. Genotype Analysis of Respiratory Syncytial Virus Before and After the COVID-19 Pandemic Using Whole-Genome Sequencing: A Prospective, Single-Center Study in Korea From 2019 to 2022.

Author

Na B, Park YJ, Seo J, Park M, Baek JY, Lee JY, Kim M, Ahn JG, Lee ST, and Kang JM

Subjects
Humans, Prospective Studies, Republic of Korea epidemiology, Drug Resistance, Viral genetics, Antiviral Agents therapeutic use, Genome, Viral, Palivizumab therapeutic use, Female, Mutation, Male, Child, Child, Preschool, Infant, Antibodies, Monoclonal, Humanized therapeutic use, COVID-19 virology, COVID-19 epidemiology, Genotype, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections virology, Whole Genome Sequencing, SARS-CoV-2 genetics, SARS-CoV-2 isolation & purification, Respiratory Syncytial Virus, Human genetics, Respiratory Syncytial Virus, Human isolation & purification
Abstract

Background: Respiratory syncytial virus (RSV), a highly transmissible virus, is the leading cause of lower respiratory tract infections. We examined molecular changes in the RSV genome before and after the coronavirus disease 2019 (COVID-19) pandemic in Korea, and investigated whether drug-resistant mutations were present., Methods: In this prospective, single-center study, RSV-positive respiratory samples were collected between September 2019 and December 2022. Long-read whole-genome sequencing (WGS) was performed, and the presence of known drug-resistant substitutions for palivizumab, nirsevimab, and suptavumab was investigated., Results: Overall, 288 respiratory samples were collected from 276 children. WGS data were available for 133 samples (71 and 62 samples from the pre- and post-pandemic periods, respectively). All RSV-A strains (n = 56) belonged to the GA2.3.5 (ON1) genotype, whereas all RSV-B strains (n = 77) belonged to the GB5.0.5a (BA) genotype. No significant differences in genotypes were observed between the pre- and post-pandemic periods. In addition, no notable mutations related to nirsevimab or palivizumab resistance were detected in the F gene. However, the L172Q and S173L substitutions, which are known to confer resistance to suptavumab, were present in all RSV-B samples., Conclusion: Despite the unprecedented interruption of RSV seasonality, there were no significant molecular changes in circulating RSV strains in Korea related to nirsevimab or palivizumab resistance before and after the COVID-19 pandemic. However, RSV-specific drug-resistance substitutions for suptavumab were identified., Competing Interests: The authors have no potential conflicts of interest to disclose., (© 2024 The Korean Academy of Medical Sciences.)

Published
2024
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