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1. AB1553-HPR BASELINE CHARACTERISTICS OF PATIENTS WITH SLE ACROSS 5 REGISTRIES – THE LUPUSNET FEDERATED DATA NETWORK

Author

Sbarigia, U., primary, Zazzetti, F., additional, Lewi, M., additional, Van Speybroeck, M., additional, Simon, T. A., additional, Li, G., additional, Sonmez, R., additional, Carter, C., additional, Karyekar, C. S., additional, Noel, W., additional, Ugarte-Gil, M. F., additional, Gamboa-Cardenas, R. V., additional, Pons-Estel, G., additional, Borba, E. F., additional, Massardo, L., additional, Aroca Martínez, G., additional, Muñoz Louis, R., additional, Moreno Alvarez, M., additional, García De La Torre, I., additional, Acosta Colmán, I., additional, Mora Trujillo, C., additional, Danza, Á., additional, Michaud, K., additional, Katz, P., additional, Kandane-Rathnayake, R., additional, Morand, E., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, LI, Z., additional, Sockalingam, S., additional, Harigai, M., additional, Zhang, Z., additional, Basnayake, D., additional, Chan, M., additional, Takeuchi, T., additional, Bae, S. C., additional, Goldblatt, F., additional, ’neill, S. O, additional, Ng, K. P. L., additional, Tugnet, N., additional, Kumar, S., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Hoi, A., additional, Nikpour, M., additional, Rúa-Figueroa, Í., additional, Pego-Reigosa, J. M., additional, Galindo-Izquierdo, M., additional, Calvo Alén, J., additional, Fernández-Nebro, A., additional, Menor-Almagro, R., additional, and Lavie, F., additional

Published
2024
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2. POS0152 PREVALENCE AND OUTCOMES OF SEVERE REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): OBSERVATIONS FROM A MULTINATIONAL COHORT

Author

Kandane-Rathnayake, R., primary, Louthrenoo, W., additional, Lau, C. S., additional, Hamijoyo, L., additional, Cho, J., additional, Lateef, A., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, Chen, Y. H., additional, Oon, S., additional, Chan, M., additional, Sockalingam, S., additional, Hao, Y., additional, Zhang, Z., additional, Bae, S. C., additional, Kikuchi, J., additional, Takeuchi, T., additional, Katsumata, Y., additional, Harigai, M., additional, Basnayake, D., additional, Goldblatt, F., additional, ’neill, S. O, additional, Ng, K. P. L., additional, Tugnet, N., additional, Kumar, S., additional, Law Hui Nee, A., additional, Tee, C., additional, Tee, M., additional, Ohkubo, N., additional, Jullion, A., additional, Shisha, T., additional, Tanaka, Y., additional, Golder, V., additional, Nikpour, M., additional, Hoi, A., additional, and Morand, E., additional

Published
2024
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6. Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

Author

Martins, M, Williams, AH, Comeau, M, Marion, M, Ziegler, JT, Freedman, BI, Merrill, JT, Glenn, SB, Kelly, JA, Sivils, KM, James, JA, Guthridge, JM, Alarcón-Riquelme, ME, Bae, S-C, Kim, J-H, Kim, D, Anaya, J-M, Boackle, SA, Criswell, LA, Kimberly, RP, Alarcón, GS, Brown, EE, Vilá, LM, Petri, MA, Ramsey-Goldman, R, Niewold, TB, Tsao, BP, Gilkeson, GS, Kamen, DL, Jacob, CO, Stevens, AM, Gaffney, PM, Harley, JB, Langefeld, CD, and Fesel, C

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Autoimmune Disease, Lupus, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Adult, Asian People, CD3 Complex, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Lupus Erythematosus, Systemic, Male, Polymorphism, Single Nucleotide, T-Lymphocytes, White People, Immunology
Abstract

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic population. We typed 44 contiguous CD247 single-nucleotide polymorphisms (SNPs) in 8922 SLE patients and 8077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99 × 10(-4) < P < 4.15 × 10(-2)), where we further identified a five-marker haplotype (rs12141731-rs2949655-rs16859085-rs12144621-rs858554; G-G-A-G-A; P(hap) = 2.12 × 10(-5)) that exceeded the most associated single SNP rs858554 (minor allele frequency in controls = 13%; P = 4.99 × 10(-4), odds ratio = 1.32) in significance. Imputation and subsequent association analysis showed evidence of association (P < 0.05) at 27 additional SNPs within intron 1. Cross-ethnic meta-analysis, assuming an additive genetic model adjusted for population proportions, showed five SNPs with significant P-values (1.40 × 10(-3) < P< 3.97 × 10(-2)), with one (rs704848) remaining significant after Bonferroni correction (P(meta) = 2.66 × 10(-2)). Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

Published
2015

7. Anti-C1q antibodies in systemic lupus erythematosus

Author

Orbai, A-M, Truedsson, L, Sturfelt, G, Nived, O, Fang, H, Alarcón, GS, Gordon, C, Merrill, Jt, Fortin, PR, Bruce, IN, Isenberg, DA, Wallace, DJ, Ramsey-Goldman, R, Bae, S-C, Hanly, JG, Sanchez-Guerrero, J, Clarke, AE, Aranow, CB, Manzi, S, Urowitz, MB, Gladman, DD, Kalunian, KC, Costner, MI, Werth, VP, Zoma, A, Bernatsky, S, Ruiz-Irastorza, G, Khamashta, MA, Jacobsen, S, Buyon, JP, Maddison, P, Dooley, MA, Van Vollenhoven, RF, Ginzler, E, Stoll, T, Peschken, C, Jorizzo, JL, Callen, JP, Lim, SS, Fessler, BJ, Inanc, M, Kamen, DL, Rahman, A, Steinsson, K, Franks, AG, Sigler, L, Hameed, S, Pham, N, Brey, R, Weisman, MH, McGwin, G, Magder, LS, and Petri, M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Lupus, Clinical Research, Autoimmune Disease, Inflammatory and immune system, Adult, Antibodies, Antinuclear, Case-Control Studies, Complement C1q, Complement System Proteins, Cross-Sectional Studies, DNA, Female, Humans, Lupus Erythematosus, Systemic, Lupus Nephritis, Male, Middle Aged, Proteinuria, Rheumatic Diseases, Sensitivity and Specificity, Young Adult, Anti-dsDNA antibodies, renal lupus, systemic lupus erythematosus, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveAnti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.MethodsInformation and blood samples were obtained in a cross-sectional study from patients with SLE (n = 308) and other rheumatologic diseases (n = 389) from 25 clinical sites (84% female, 68% Caucasian, 17% African descent, 8% Asian, 7% other). IgG anti-C1q against the collagen-like region was measured by ELISA.ResultsPrevalence of anti-C1q was 28% (86/308) in patients with SLE and 13% (49/389) in controls (OR = 2.7, 95% CI: 1.8-4, p

Published
2015

11. POS1481 INFORMING TRIAL MEASUREMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS: FREQUENCY OF DOMAIN-SPECIFIC DISEASE ACTIVITY IN A MULTI-NATIONAL OBSERVATIONAL COHORT

Author

Connelly, K., primary, Kandane-Rathnayake, R., additional, Golder, V., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Oon, S., additional, Bae, S. C., additional, Goldblatt, F., additional, O’neill, S., additional, Ng, K., additional, Law, A., additional, Basnayake, B., additional, Tugnet, N., additional, Kumar, S., additional, Tee, C., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Hoi, A., additional, and Morand, E. F., additional

Published
2023
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12. AB0697 COMPARISON OF COVID-19 VACCINATION WITH INFLUENZA VACCINATION IN KOREAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: PERCEPTION, ADVERSE EVENTS, AND FLARES FROM THE CIVIL STUDY

Author

Shim, S. C., primary, Lee, J., additional, Lee, Y. H., additional, Kwok, S. K., additional, Kim, Y. G., additional, Park, Y., additional, Park, S. H., additional, Bae, S. C., additional, Suh, C. H., additional, Sung, Y. K., additional, Lee, S. S., additional, Lee, C. K., additional, Lee, H. S., additional, Jung, S. M., additional, and Cha, H. S., additional

Published
2023
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13. OP0048 RISK OF FLARE AND DAMAGE ACCRUAL AFTER TAPERING GLUCOCORTICOIDS IN SEROLOGICALLY ACTIVE CLINICALLY QUIESCENT PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Author

Katsumata, Y., primary, Inoue, E., additional, Harigai, M., additional, Kandane-Rathnayake, R., additional, Louthrenoo, W., additional, Hoi, A., additional, Golder, V., additional, Lau, C. S., additional, Cho, J., additional, Lateef, A., additional, Chen, Y. H., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Hamijoyo, L., additional, Li, Z., additional, Sockalingam, S., additional, Navarra, S., additional, Zamora, L., additional, Hao, Y., additional, Zhang, Z., additional, Chan, M., additional, Oon, S., additional, Ng, K., additional, Kikuchi, J., additional, Takeuchi, T., additional, Goldblatt, F., additional, O’neill, S., additional, Tugnet, N., additional, Law, A., additional, Bae, S. C., additional, Tanaka, Y., additional, Ohkubo, N., additional, Kumar, S., additional, Nikpour, M., additional, and Morand, E. F., additional

Published
2023
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14. OP0226 ATTAINMENT OF LUPUS LOW DISEASE ACTIVITY STATE EXCLUSIVE OF REMISSION IS PROTECTIVE AGAINST ADVERSE OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS

Author

Kandane-Rathnayake, R., primary, Golder, V., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Basnayake, B., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Oon, S., additional, Bae, S. C., additional, O’neill, S., additional, Goldblatt, F., additional, Ng, K., additional, Law, A., additional, Tugnet, N., additional, Kumar, S., additional, Tee, M., additional, Tee, C., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Hoi, A., additional, and Morand, E. F., additional

Published
2023
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20. Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes.

Author

Choi, M. Y., Hanly, J., Bae, S.-C., Romero-Diaz, J., Sanchez-Guerrero, J., Bernatsky, S., Wallace, D. J., Isenberg, D. A., Rahman, A., Merrill, J. T., Fortin, P. R., Ramsey-Goldman, R., Manzi, S., Jönsen, A., Alarcón, G. S., van Vollenhoven C. Aranow M. Mackay, R. F., Ruiz-Irastorza, G., Kalunian, K., Kamen, D. L., and Askanase, A.

Published
2023
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31. OP0110 CELL-TYPE-SPECIFIC TRANSCRIPTOME ARCHITECTURE UNDERLYING THE ESTABLISHMENT AND EXACERBATION OF SYSTEMIC LUPUS ERYTHEMATOSUS

Author

Nakano, M., primary, Ota, M., additional, Takeshima, Y., additional, Iwasaki, Y., additional, Hatano, H., additional, Nagafuchi, Y., additional, Kim, K., additional, Bang, S. Y., additional, Lee, H. S., additional, Shoda, H., additional, Zhang, X., additional, Bae, S. C., additional, Terao, C., additional, Yamamoto, K., additional, Okamura, T., additional, Ishigaki, K., additional, and Fujio, K., additional

Published
2022
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33. POS0121 ASSOCIATION OF LUPUS LOW DISEASE ACTIVITY STATE ATTAINMENT WITH REDUCED ORGAN DAMAGE AND FLARE IN SLE PATIENTS WITH HIGH DISEASE ACTIVITY

Author

Kandane-Rathnayake, R., primary, Golder, V., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, Li, Z., additional, An, Y., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Basnayake, B., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Bae, S. C., additional, Oon, S., additional, O’neill, S., additional, Goldblatt, F., additional, Gibson, K., additional, Ng, K., additional, Law, A., additional, Tugnet, N., additional, Kumar, S., additional, Tee, C., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Morand, E. F., additional, and Hoi, A., additional

Published
2022
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34. OP0142 COMPARISON OF ATTAINMENT AND PROTECTIVE EFFECTS OF THE LUPUS LOW DISEASE ACTIVITY STATE IN PATIENTS WITH NEWLY DIAGNOSED VERSUS ESTABLISHED SLE - A MULTICENTRE PROSPECTIVE STUDY

Author

Golder, V., primary, Kandane-Rathnayake, R., additional, Louthrenoo, W., additional, Chen, Y. H., additional, Cho, J., additional, Lateef, A., additional, Hamijoyo, L., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, An, Y., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Basnayake, B., additional, Chan, M., additional, Kikuchi, J., additional, Takeuchi, T., additional, Bae, S. C., additional, O’neill, S., additional, Goldblatt, F., additional, Oon, S., additional, Gibson, K., additional, Ng, K., additional, Law, A., additional, Tugnet, N., additional, Kumar, S., additional, Tee, C., additional, Tee, M., additional, Tanaka, Y., additional, Lau, C. S., additional, Nikpour, M., additional, Hoi, A., additional, and Morand, E. F., additional

Published
2022
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42. 2021 DORIS definition of remission in SLE: Final recommendations from an international task force

Author

van Vollenhoven, R.F. Bertsias, G. Doria, A. Isenberg, D. Morand, E. Petri, M.A. Pons-Estel, B.A. Rahman, A. Ugarte-Gil, M.F. Voskuyl, A. Arnaud, L. Bruce, I.N. Cervera, R. Costedoat-Chalumeau, N. Gordon, C. Houssiau, F.A. Mosca, M. Schneider, M. Ward, M.M. Alarcon, G. Aringer, M. Askenase, A. Bae, S.-C. Bootsma, H. Boumpas, D.T. Brunner, H. Clarke, A.E. Coney, C. Czirják, L. Dörner, T. Faria, R. Fischer, R. Fritsch-Stork, R. Inanc, M. Jacobsen, S. Jayne, D. Kuhn, A. van Leeuw, B. Limper, M. Mariette, X. Navarra, S. Nikpour, M. Olesinska, M.H. Pons-Estel, G. Romero-Diaz, J. Rubio, B. Schoenfeld, Y. Bonfá, E. Smolen, J. Teng, Y.K.O. Tincani, A. Tsang-A-Sjoe, M. Vasconcelos, C. Voss, A. Werth, V.P. Zakharhova, E. Aranow, C.

Subjects
skin and connective tissue diseases
Abstract

Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment

Published
2021

44. POS0028 DEFINING THE PREVALENCE OF UNMET NEED IN SLE: DATA FROM A LARGE MULTINATIONAL LONGITUDINAL SLE COHORT

Author

Kandane-Rathnayake, R., primary, Louthrenoo, W., additional, Hoi, A., additional, Golder, V., additional, Chen, Y. H., additional, Luo, S. F., additional, Jan Wu, Y. J., additional, Lateef, A., additional, Cho, J., additional, Hamijoyo, L., additional, Lau, C. S., additional, Navarra, S., additional, Zamora, L., additional, LI, Z., additional, An, Y., additional, Sockalingam, S., additional, Katsumata, Y., additional, Harigai, M., additional, Hao, Y., additional, Zhang, Z., additional, Kikuchi, J., additional, Takeuchi, T., additional, Basnayake, B., additional, Goldblatt, F., additional, Chan, M., additional, Ng, K., additional, Bae, S. C., additional, Oon, S., additional, O’neill, S., additional, Gibson, K., additional, Kumar, S., additional, Tugnet, N., additional, Tanaka, Y., additional, Nikpour, M., additional, and Morand, E. F., additional

Published
2021
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45. OP0289 LLDAS (LOW LUPUS DISEASE ACTIVITY STATE), LOW DISEASE ACTIVITY (LDA) AND REMISSION (ON- OR OFF-TREATMENT) PREVENT DAMAGE ACCRUAL IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS IN A MULTINATIONAL MULTICENTER COHORT

Author

Ugarte-Gil, M. F., primary, Hanly, J., additional, Urowitz, M. B., additional, Gordon, C., additional, Bae, S. C., additional, Romero-Diaz, J., additional, Sanchez-Guerrero, J., additional, Bernatsky, S., additional, Clarke, A. E., additional, Wallace, D. J., additional, Isenberg, D., additional, Rahman, A., additional, Merrill, J. T., additional, Fortin, P., additional, Gladman, D. D., additional, Bruce, I. N., additional, Petri, M. A., additional, Ginzler, E. M., additional, Dooley, M. A., additional, Ramsey-Goldman, R., additional, Manzi, S., additional, Jonsen, A., additional, Van Vollenhoven, R., additional, Aranow, C., additional, Mackay, M., additional, Ruiz-Irastorza, G., additional, Lim, S. S., additional, Inanc, M., additional, Kalunian, K. C., additional, Jacobsen, S., additional, Peschken, C., additional, Kamen, D. L., additional, Askanase, A., additional, Pons-Estel, B., additional, and Alarcon, G. S., additional

Published
2021
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46. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

Author

Wang, S, Adrianto, I, Wiley, G B, Lessard, C J, Kelly, J A, Adler, A J, Glenn, S B, Williams, A H, Ziegler, J T, Comeau, M E, Marion, M C, Wakeland, B E, Liang, C, Kaufman, K M, Guthridge, J M, Alarcón-Riquelme, M E, Alarcón, G S, Anaya, J-M, Bae, S-C, Kim, J-H, Joo, Y B, Boackle, S A, Brown, E E, Petri, M A, Ramsey-Goldman, R, Reveille, J D, Vilá, L M, Criswell, L A, Edberg, J C, Freedman, B I, Gilkeson, G S, Jacob, C O, James, J A, Kamen, D L, Kimberly, R P, Martin, J, Merrill, J T, Niewold, T B, Pons-Estel, B A, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Harley, J B, Wakeland, E K, Moser, K L, Montgomery, C G, and Gaffney, P M

Published
2012
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47. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis

Author

Lin, C P, Adrianto, I, Lessard, C J, Kelly, J A, Kaufman, K M, Guthridge, J M, Freedman, B I, Anaya, J-M, Alarcón-Riquelme, M E, Pons-Estel, B A, Martin, J, Glenn, S, Adler, A, Bae, S-C, Park, S-Y, Bang, S-Y, Song, Y-W, Boackle, S A, Brown, E E, Edberg, J C, Alarcón, G S, Petri, M A, Criswell, L A, Ramsey-Goldman, R, Reveille, J D, Vila, L M, Gilkeson, G S, Kamen, D L, Ziegler, J, Jacob, C O, Rasmussen, A, James, J A, Kimberly, R P, Merrill, J T, Niewold, T B, Scofield, R H, Stevens, A M, Tsao, B P, Vyse, T J, Langefeld, C D, Moser, K L, Harley, J B, Gaffney, P M, and Montgomery, C G

Published
2012
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48. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort

Author

Namjou, B, Kothari, P H, Kelly, J A, Glenn, S B, Ojwang, J O, Adler, A, Alarcón-Riquelme, M E, Gallant, C J, Boackle, S A, Criswell, L A, Kimberly, R P, Brown, E, Edberg, J, Stevens, A M, Jacob, C O, Tsao, B P, Gilkeson, G S, Kamen, D L, Merrill, J T, Petri, M, Goldman, R R, Vila, L M, Anaya, J-M, Niewold, T B, Martin, J, Pons-Estel, B A, Sabio, J M, Callejas, J L, Vyse, T J, Bae, S-C, Perrino, F W, Freedman, B I, Scofield, R H, Moser, K L, Gaffney, P M, James, J A, Langefeld, C D, Kaufman, K M, Harley, J B, and Atkinson, J P

Published
2011
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