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249 results on '"Bae, Chang Hoon"'

9. C-C Motif Chemokine Receptor 3-Mediated Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase Signaling: Promising Targets for Human Airway Epithelial Mucin 5AC Induction by Eotaxin-2 and Eotaxin-3.

Author

Jo, Sooyeon, Na, Hyung Gyun, Choi, Yoon Seok, Bae, Chang Hoon, Song, Si-Youn, and Kim, Yong-Dae

Subjects
MITOGEN-activated protein kinase kinase, MITOGEN-activated protein kinases, PROTEIN kinases, CHEMOKINE receptors, EXTRACELLULAR matrix proteins, MUCINS, GENE expression
Abstract

Introduction: Eotaxin-2 and -3 of the C-C chemokine subfamily function as potent chemoattractant factors for eosinophil recruitment and various immune responses in allergic and inflammatory airway diseases. Mucin 5AC (MUC5AC), a major gel-forming secretory mucin, is overexpressed in airway inflammation. However, the association between mucin secretion and eotaxin-2/3 expression in the upper and lower airway epithelial cells has not been fully elucidated. Therefore, in this study, we investigated the effects of eotaxin-2/3 on MUC5AC expression and its potential signaling mediators. Methods: We analyzed the effects of eotaxin-2 and -3 on NCI-H292 human airway epithelial cells and primary human nasal epithelial cells (HNEpCs) via reverse transcription-polymerase chain reaction, enzyme-linked immunosorbent assay, and western blotting. Along with immunoblot analyses with specific inhibitors and small interfering RNA (siRNA), we explored the signaling pathway involved in MUC5AC expression following eotaxin-2/3 treatment. Results: In HCI-H292 cells, eotaxin-2/3 activated the mRNA expression and protein production of MUC5AC. A specific inhibitor of C-C motif chemokine receptor 3 (CCR3), SB328437, suppressed eotaxin-2/3-induced MUC5AC expression at both the mRNA and protein levels. Eotaxin-2/3 induced the phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 and p38, whereas pretreatment with a CCR3 inhibitor significantly attenuated this effect. Induction of MUC5AC expression with eotaxin-2/3 was decreased by U0126 and SB203580, specific inhibitors of ERK1/2 and p38 mitogen-activated protein kinase (MAPK), respectively. In addition, cell transfection with ERK1/2 and p38 siRNAs inhibited eotaxin-2/3-induced MUC5AC expression. Moreover, specific inhibitors (SB328437, U0126, and SB203580) attenuated eotaxin-2/3-induced MUC5AC expression in HNEpCs. Conclusion: Our results imply that CCR3-mediated ERK1/2 and p38 MAPK are involved in the signal transduction of eotaxin-2/3-induced MUC5AC overexpression. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Association Between Length of Stay in the Intensive Care Unit and Sarcopenia Among Hemiplegic Stroke Patients

Author

Jang, Aeri, Bae, Chang Hoon, Han, Soo Jeong, and Bae, Hasuk

Subjects
medicine.medical_specialty, Multivariate analysis, intensive care units, lcsh:Medicine, 030204 cardiovascular system & hematology, Logistic regression, law.invention, sarcopenia, 03 medical and health sciences, 0302 clinical medicine, length of stay, law, Internal medicine, Medicine, bioelectrical impedance analysis, 030212 general & internal medicine, Stroke, business.industry, Rehabilitation, lcsh:R, Odds ratio, medicine.disease, musculoskeletal system, Intensive care unit, stroke, Confidence interval, body regions, Sarcopenia, Original Article, business, Bioelectrical impedance analysis, human activities
Abstract

Objective To discuss the association between the length of stay at the intensive care unit (ICU) and sarcopenia among hemiplegic stroke patients.Methods This study evaluated 66 hemiplegic stroke patients with history of ICU admission using handgrip strength and bioelectrical impedance analysis to obtain height-adjusted appendicular skeletal muscle mass. The diagnosis of sarcopenia was made according to the muscle mass based on the Asian Working Group for Sarcopenia. The patients were divided into sarcopenic and non-sarcopenic groups. The two groups were statistically analyzed, and the significant factors with differences were studied. A multivariate logistic regression analysis was performed to examine the association between length of stay in the ICU and sarcopenia, after adjusting for potential confounders.Results Among 66 hemiplegic patients with an ICU admission history, 12 patients were diagnosed with sarcopenia. Sarcopenia patients showed lower scores on the Korean version of the Modified Barthel Index and the Korean version of the Mini-Mental State Examination. Additionally, patients with sarcopenia had a longer length of stay in the ICU, and univariate and multivariate analyses confirmed that the ICU length of stay was significantly related to sarcopenia (adjusted odds ratio=1.187; 95% confidence interval, 1.019–1.382; p=0.028).Conclusion The length of stay in the ICU was significantly associated with sarcopenia in hemiplegic stroke patients.

Published
2021

43. Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells.

Author

Kwak, Soyoung, Choi, Yoon Seok, Na, Hyung Gyun, Bae, Chang Hoon, Song, Si-Youn, and Kim, Yong-Dae

Subjects
EPITHELIAL cells, CYTOKINES, MUCINS, GLYOXAL, MITOGEN-activated protein kinases, TALL-1 (Protein)
Abstract

Background: Glyoxal (GO), and methylglyoxal (MGO) are among the most toxic compounds emitted by electronic cigarette (E-cig) and regular tobacco cigarette smoke. Airway diseases presented mucus over production as their major pathophysiologic feature. However, the effects of GO and MGO on pro-inflammatory cytokines and mucin expression in human nasal epithelial cells, as well as the underlying signaling pathway, have not yet been studied. Objective: This study is to determine whether GO and MGO induce pro-inflammatory cytokines, and MUC5AC/5B expression via mitogen-activated protein kinase (MAPK)s and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways. Methods: The effect of GO, and MGO on pro-inflammatory cytokines, mucins expression and the signalling pathway of GO and MGO were investigated using water-soluble tetrazolium salt-1, enzyme immunoassays, and immunoblot analysis with specific inhibitors and small interfering RNA. Results: GO and MGO did not affect cell viability up to 2 mM in human nasal epithelial cells. GO and MGO increased production of pro-inflammatory such as interleukin (IL)-1β and IL-6) and MUC5AC/5B. Additionally, GO and MGO significantly activated extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and NF-κB. Whether ERK1/2, p38 MAPK, and NF-κB signaling pathway were involved in GO and MGO-induced production of pro-inflammatory cytokines (IL-1β and IL-6) and MUC5AC/5B, we used specific inhibitors and siRNA transfection. These significantly repressed GO- and MGO-induced expression of pro-inflammatory cytokines (IL-1β and IL-6) and MUC5AC/5B. Conclusions: GO and MGO induced pro-inflammatory cytokines and MUC5AC/5B expression via ERK1/2, p38 MAPK, and NF-κB in human nasal epithelial cells. These results suggested that GO and MGO may be involved in mucus hypersecretion-related airway diseases. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Primary Small Cell Neuroendocrine Carcinoma in the Sublingual Gland: A Case Report.

Author

Na, Hyung Gyun, Bae, Chang Hoon, Kim, Yong-Dae, Song, Si-Youn, and Choi, Yoon Seok

Subjects
*ADENOCARCINOMA, *SUBLINGUAL gland, *SMALL cell carcinoma, *COLECTOMY, *COLORECTAL cancer, *NEUROENDOCRINE tumors
Abstract

The article describes the case of primary small cell neuroendocrine carcinoma in the sublingual gland of a 94-year-old female patient. The patient was presented with slow-growing mass on the mouth floor mass. She was also diagnosed with colorectal adenocarcinoma after undergoing laparoscopic right hemicolectomy. The patient opted to refuse adjuvant radiation therapy due to old age and her general condition.

Published
2022
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