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Asim Roy,1 Diane Ito,2 Susan Morris,3 Shawn Candler,4 Judi Profant,3 Charles Bae5 1Ohio Sleep Medicine Institute, Dublin, OH, USA; 2Stratevi LLC, Santa Monica, CA, USA; 3Jazz Pharmaceuticals, Palo Alto, CA, USA; 4Jazz Pharmaceuticals, Philadelphia, PA, USA; 5Penn Sleep Center, University of Pennsylvania, Philadelphia, PA, USACorrespondence: Asim Roy, Ohio Sleep Medicine Institute, 4975 Bradenton Avenue, Dublin, OH, 43017, USA, Tel +1 614-766-0773, Fax +1 614-766-2599, Email aroy@sleepmedicine.comPurpose: Real-world data regarding divided nightly dosing of oxybate and individualized prescribing in patients with narcolepsy are limited. Study objectives were to understand oxybate prescribing practices, including optimizing dose regimens and adjusting dosing per occasional changes in patients’ routines, and physician recommendations for representative patient scenarios.Patients and Methods: A cross-sectional, web- and audio-based survey of physicians treating ≥ 2 patients with narcolepsy, prescribed nightly oxybate (sodium oxybate) dosing for ≥ 6 months, was conducted. Physicians were surveyed on patients’ usual oxybate dosing regimens, frequency of and reasons for oxybate dosing-related discussions, and preferred methods for and perceptions of adjusting oxybate dosing. Physicians provided dosing-related guidance for 4 representative scenarios.Results: Participating physicians (N=25) were neurologists (52%), psychiatrists (44%), and neuropsychiatrists (4%). Individualized oxybate prescribing practices were reflected by the variability of physicians’ reporting of the percentage of their patients being prescribed once-nightly, twice-nightly, and thrice-nightly dosing regimens. Most physicians (68%) reported discussing adjusting individualized treatment to accommodate occasional changes to patients’ routines; the most common reasons were consuming contraindicated beverages (alcohol; 65%) and travel (59%). Adjusting total nightly dose (68%) and dose timing (68%) were preferred adjustment methods. Most physicians (88%) felt the ability to individualize oxybate dosing was important and had a positive impact on ability to provide care. For each representative scenario, physicians provided several dose-adjustment recommendations, and physician responses encouraged patient participation in treatment decision-making.Conclusion: Physicians provided guidance supportive of oxybate dose adjustments to accommodate occasional changes in patients’ routines, and perceived individualized dosing as important in providing care.Plain Language Summary: Why was the research needed?Narcolepsy is an uncommon condition that causes individuals to feel sleepy throughout the day. Other symptoms may include sudden muscle weakness. There is no cure for narcolepsy, but there are several treatments, including medicines known as oxybates. This study focused on how doctors use oxybate to treat patients with narcolepsy.How was the research done?This study was an online survey of doctors who were treating 2 or more patients with narcolepsy. Patients had been taking oxybate for at least 6 months. The survey asked doctors about their patients’ normal oxybate usage, how often and why they discussed oxybate treatment, and which ways oxybate treatment was usually adjusted.What are the results?Twenty-five doctors took part in this study. Most doctors said they discuss personalized treatment to help with occasional changes in their patients’ daily lives. The most common reasons for making treatment changes were consuming alcohol and travel. The most common changes were total nightly amount and timing of oxybate. Most doctors said the ability to personalize oxybate treatment is important and has a positive impact.What does the research mean?This study provides valuable knowledge on real-world oxybate treatment patterns and the conditions when doctors make clinical decisions about treating patients with narcolepsy.Graphical Abstract: Keywords: sodium oxybate, low-sodium oxybate, calcium, magnesium, potassium, sodium oxybates, prescribing patterns, personalized dosing

Electron Beam Ion Traps (EBITs) serve as efficient tools for producing and studying highly charged ions. In response to the diagnostic requirements of upcoming magnetic confinement fusion devices, a medium-energy atomic spectra research platform based on a compact EBIT is developed. This platform achieves a central magnetic field of up to 1.0 T, with electron beam currents reaching 20 mA and electron energies up to 30 keV, similar to the electron temperature on fusion reactors. The developed atomic spectra platform successfully provided spectral data for elements such as argon, xenon, iron, and tungsten. This platform stands as a valuable asset for advancing research in nuclear fusion, particularly concerning impurity spectroscopic diagnostics. [ABSTRACT FROM AUTHOR]

Plasma toroidal rotation acceleration in the co-current direction introduced by the n = 1 (toroidal mode number) static resonant magnetic perturbation (RMP) has been observed in the EAST tokamak. It strongly depends on the RMP coil configuration, which is manifested by its dependence on δ ϕ U L (phase difference between upper and lower coils) and RMP current. Modeling results from NTVTOK based on the linear plasma response modeled by MARS-F shows that the Neoclassical Toroidal Viscosity (NTV) torque is in the co-current direction because of the dominant contribution from electrons with the condition that the electron normalized collisionality is much lower than that of ions in this experiment. The modeled dependence of core integrated NTV torque modulated by the magnitude of core magnetic perturbation on δ ϕ U L is consistent with the experimental observations. Threshold condition related to normalized collisionality to achieve the transition from rotation braking to acceleration is obtained in the NTV modeling and agrees well with experimental observations. It is shown in the modeling that the discharges with rotation acceleration are located at the regime that electron contribution to NTV is dominant and the torque is in co-current direction, while others with rotation braking are located at the regime that ion contribution to NTV torque is dominant and the torque is in countercurrent direction. Though the modeling results are in qualitative agreement with the experimental results, there is quantity difference between the modeled NTV torque based on linear plasma response and the experimental values. Possible reason is that the 3D fields are underestimated by linear modeling, particularly in the case of RMP field penetration, as demonstrated by the RMP current threshold for the rotation acceleration observed in the experiments. [ABSTRACT FROM AUTHOR]

The various effects of temperature on the Ginzburg-Landau parameter, thermodynamic and upper critical field of the [Nb.sub.3]Sn strands are being discussed. The results show that the surface barrier is responsible for the asymmetry shown in the magnetic relaxation rate for flux entry and exit.

There is a trade-off between employment protection and pollution control, but the case of Los Angeles shows that jobs can also be created from pollution control. High-wage jobs may also be lost. It is not clear that pollution control is regressive. Poorer people may live in more polluted areas, and thus benefit more from clean air measures. Simple divisions between rich and poor are not always helpful, since there are different effects within these groups. The net impact of implementing clean air measures is likely to be progressive in general terms in Los Angeles.