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1. Association of Adverse Perinatal Outcomes of Intrahepatic Cholestasis of Pregnancy With Biochemical Markers: Results of Aggregate and Individual Patient Data Meta-Analyses

Author

Ovadia, C., Seed, P.T., Sklavounos, A., Geenes, B., Di Ilio, C., Chambers, J., Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., Bull, L., Estiú, M.C., Grymowicz, M., Gunaydin, B., Hague, W.M., Haslinger, C., Hu, Y., Kawakita, T., Kebapcilar, A.G., Kebapcilar, L., Kondrackienė, J., Koster, M.P.H., Kowalska-Kańka, A., Kupčinskas, L., Lee, R.H., Locatelli, A., Macias, R.I.R., Marschall, H.U., Oudijk, M.A., Raz, Y., Rimon, E., Shan, D., Shao, Y., Tribe, R., Tripodi, V., Abide, C.Y., Yenidede, I., Thornton, J.G., Chappell, L.C., and Williamson, C.

Published
2020
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3. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: Results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackiene, J, Koster, M, Kowalska-Kanka, A, Kupcinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Ovadia C., Seed P. T., Sklavounos A., Geenes V., Di Illio C., Chambers J., Kohari K., Bacq Y., Bozkurt N., Brun-Furrer R., Bull L., Estiu M. C., Grymowicz M., Gunaydin B., Hague W. M., Haslinger C., Hu Y., Kawakita T., Kebapcilar A. G., Kebapcilar L., Kondrackiene J., Koster M. P. H., Kowalska-Kanka A., Kupcinskas L., Lee R. H., Locatelli A., Macias R. I. R., Marschall H. -U., Oudijk M. A., Raz Y., Rimon E., Shan D., Shao Y., Tribe R., Tripodi V., Abide C. Y., Yenidede I., Thornton J. G., Chappell L. C., Williamson C., Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackiene, J, Koster, M, Kowalska-Kanka, A, Kupcinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Ovadia C., Seed P. T., Sklavounos A., Geenes V., Di Illio C., Chambers J., Kohari K., Bacq Y., Bozkurt N., Brun-Furrer R., Bull L., Estiu M. C., Grymowicz M., Gunaydin B., Hague W. M., Haslinger C., Hu Y., Kawakita T., Kebapcilar A. G., Kebapcilar L., Kondrackiene J., Koster M. P. H., Kowalska-Kanka A., Kupcinskas L., Lee R. H., Locatelli A., Macias R. I. R., Marschall H. -U., Oudijk M. A., Raz Y., Rimon E., Shan D., Shao Y., Tribe R., Tripodi V., Abide C. Y., Yenidede I., Thornton J. G., Chappell L. C., and Williamson C.

Published
2019

6. Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring

Author

Staub, F., Tournoux-Facon, C., Roumy, J., Chaigneau, C., Morichaut-Beauchant, M., Levillain, P., Prevost, C., Aubé, C., Lebigot, J., Oberti, F., Galtier, J. B., Laumonier, H., Trillaud, H., Bernard, P. H., Blanc, J. F., Sironneau, S., Machet, F., Drouillard, J., de Ledinghen, V., Couzigou, P., Foucher, P., Castéra, L., Tranquard, F., Bacq, Y., d’Altéroche, L., Ingrand, P., and Tasu, J. P.

Published
2009
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7. Liste des collaborateurs

Author

Almange, C., primary, Andrès, P., additional, Arcangeli-Belgy, M.-T., additional, Artus, M., additional, Assari, F., additional, Bacq, Y., additional, Bader, G., additional, Balouet, P., additional, Baraille, A., additional, Bardin-Bedu, C., additional, Beillat, T., additional, Benoist, G., additional, Beucher, G., additional, Blanchère, J.-P., additional, Blot, P., additional, Boog, G., additional, Boulogne, A.-I., additional, Brasseur, G., additional, Buzenet, C., additional, Cabrol, D., additional, Carbonne, B., additional, Carbonneaux, S., additional, Carles, G., additional, Carluer, L., additional, Chabrolle, J.-P., additional, Coffin, C., additional, Cournot, M.-P., additional, Cuvelier, A., additional, d'Ercole, C., additional, Dallay, D., additional, Dao, T., additional, Dayan, J., additional, de Guerke, L., additional, Dejean, A., additional, Delcroix, M., additional, Deschamps, A., additional, Desprats, R., additional, Diguet, A., additional, Dompmartin, A., additional, Doyen, C., additional, Dran, C., additional, Dreyfus, M., additional, Dupuis, O., additional, Durier, M., additional, Elefant, E., additional, Evain-Brion, D., additional, Faury, M.-N., additional, Forgeard, C., additional, Fournet, P., additional, Fournier, T., additional, Gabriel, R., additional, Galley-Raulin, F., additional, Galliot, L., additional, Gaucherand, P., additional, Giami, I., additional, Goffinet, F., additional, Golfier, F., additional, Gomez, C., additional, Gondry, J., additional, Gouyon, J.-B., additional, Grossetti, E., additional, Grout, M.-A., additional, Grynberg, M., additional, Guillaume, S., additional, Harvey, T., additional, Hebert, A., additional, Hillion, K., additional, Himily, V., additional, Houet-Zuccalli, T., additional, Houssin, I., additional, Kakol, M., additional, Langer, B., additional, Lansac, J., additional, Lanta, S., additional, Lavaud, M., additional, Le Querrec, A., additional, Lecointe-Jolly, V., additional, Lejeune, V., additional, Lemery, D., additional, Lepercq, J., additional, Leroy, S., additional, Lestang, I., additional, Longépé, J., additional, Lo Presti, J.-P., additional, Mahieu-Caputo, D., additional, Maillet, R., additional, Malassiné, A., additional, Mandelbrot, L., additional, Marpeau, L., additional, Marpeau-Delignière, P., additional, Marret, S., additional, Martin, S., additional, Massardier, J., additional, Mercier, C., additional, Moreau, Y., additional, Morin, C., additional, Muir, J.-F., additional, Nguyen, F., additional, Nivot-Roman, E., additional, Nizard, J., additional, Oury, J.-F., additional, Pajot-Pharose, E., additional, Parant, O., additional, Paris, F., additional, Polzin, K., additional, Provost, D., additional, Radi, S., additional, Renner, J.-P., additional, Reman, O., additional, Revaux, A., additional, Ricbourg, A., additional, Riethmuller, D., additional, Rivière, M., additional, Roman, H., additional, Rotten, D., additional, Rozenberg, P., additional, Schaal, J.-P., additional, Schnitzler, K., additional, Sentilhes, L., additional, Sergent, F., additional, Siegler, L., additional, Simon, A., additional, Simon-Toulza, C., additional, Sutter-Dallay, A.-L., additional, Szymansky, N., additional, Teurnier, F., additional, Trichot, C., additional, Tsatsaris, V., additional, Vallée, M.-M., additional, Vauzelle, C., additional, Venditelli, F., additional, Vercoustre, L., additional, Vérot, C., additional, Verspyck, E., additional, Viader, F., additional, Winer, N., additional, and Zanardi, M., additional

Published
2010
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11. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers

Author

Ovadia, C., Seed, P.T. (P.), Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J. (John), Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., Bull, I.D. (Ian), Estiu, M.C., Grymowicz, M., Gunaydin, B., Hague, W.M., Haslinger, C., Hu, Y. (Yu), Kawakita, T., Kebapcilar, A.G., Kebapcilar, L., Kondrackiene, J. (Jurate), Koster, M.P.H., Kowalska-Kanka, A., Kupcinskas, L. (Limas), Lee, R.H., Locatelli, A. (Alberta), Macias, R.I.R., Marschall, H.-U., Oudijk, M.A. (Martijn), Raz, Y., Rimon, E., Shan, D., Shao, Y, Tribe, R., Tripodi, V., Abide, C.Y., Yenidede, I., Thornton, J.G. (Jim), Chappell, LC, Williamson, C. (Catherine), Ovadia, C., Seed, P.T. (P.), Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J. (John), Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., Bull, I.D. (Ian), Estiu, M.C., Grymowicz, M., Gunaydin, B., Hague, W.M., Haslinger, C., Hu, Y. (Yu), Kawakita, T., Kebapcilar, A.G., Kebapcilar, L., Kondrackiene, J. (Jurate), Koster, M.P.H., Kowalska-Kanka, A., Kupcinskas, L. (Limas), Lee, R.H., Locatelli, A. (Alberta), Macias, R.I.R., Marschall, H.-U., Oudijk, M.A. (Martijn), Raz, Y., Rimon, E., Shan, D., Shao, Y, Tribe, R., Tripodi, V., Abide, C.Y., Yenidede, I., Thornton, J.G. (Jim), Chappell, LC, and Williamson, C. (Catherine)

Abstract

__Background__ Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. __Methods__ We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and populationbased studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logisti

Published
2019
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14. Does HIV-infection influence the response of chronic hepatitis C to interferon treatment? A French multicenter prospective study

Author

Causse, Xavier, Payen, Jean-Louis, Izopet, Jacques, Babany, Gérard, Girardin, Marie-France Saint-Marc, Bailly, F, Housset, C, Tran, A, Pariente, A, Lagasse, JP, Desmorat, H, Bettan, L, Bloch, F, Couzigou, P, Chossegros, P, Laurent, Puig P, Bacq, Y, Douvin, C, Raabe, JJ, Van Lemmens, C, Zarski, JP, Bernard, P, Rozenbaum, W, Trois Vallets, D, Fischer, D, Sogni, P, Boucher, E, Boyer, N, Lang, JM, Danne, O, Barbare, JC, Force, G, Schmit, JC, Mesnard, B, Gauthier, A, Poveda, JD, Sayada, C, Olivares, R, and Montestruc, F

Published
2000
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17. Recurrent INHBE-GLI1 fusions in hepatocellular adenomas with sonic hedgehog pathway activation

Author

Nault, J.C., primary, Couchy, G., additional, Balabaud, C., additional, Morcrette, G., additional, Caruso, S., additional, Blanc, J.-F., additional, Bacq, Y., additional, Caldéraro, J., additional, Paradis, V., additional, Ramos, J., additional, Gnemmi, V., additional, Sturm, N., additional, Savier, E., additional, Chiche, L., additional, Selves, J., additional, Pilati, C., additional, Laurent, A., additional, DeMuret, A., additional, Lebail, B., additional, Rebouissou, S., additional, Imbeaud, S., additional, Bioulac-Sage, P., additional, Letouze, E., additional, and Zucman-Rossi, J., additional

Published
2017
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20. Nosology and Molecular Classification of Hepatocellular Adenomas

Author

Nault, J.C., primary, Couchy, G., additional, Bioulac-Sage, P., additional, Bacq, Y., additional, Calderaro, J., additional, Paradis, V., additional, Ramos, J., additional, Scoazec, J.-Y., additional, Leteurtre, E., additional, Sturm, N., additional, Guettier, C., additional, Fabre, M., additional, Savier, E., additional, Chiche, L., additional, Labrune, P., additional, Selves, J., additional, Wendum, D., additional, Morcrette, G., additional, Gelabale, E., additional, Pilati, C., additional, Laurent, A., additional, De Muret, A., additional, Blanc, J.-F., additional, Le Bail, B., additional, Imbeaud, S., additional, Balabaud, C., additional, Rebouissou, S., additional, and Zucman-Rossi, J., additional

Published
2016
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22. O112 : HBsAg clearance after addition of 48 weeks of pegifn in HBeAg negative CHB patients on nucleos(T)ide therapy with undetectable hbvdna for at least one year: final results from ANRS-HB06 pegan study: multicenter randomized controlled phase III trial

Author

Bourliere, M., primary, Rabiega, P., additional, Ganne-Carrie, N., additional, Serfaty, L., additional, Marcellin, P., additional, Pouget, N., additional, Guyader, D., additional, Hezode, C., additional, Picon, M., additional, Causse, X., additional, Leroy, V., additional, Bronowicki, J.P., additional, Riachi, G., additional, Rosa, I., additional, Attali, P., additional, Molina, J.M., additional, Bacq, Y., additional, Tran, A., additional, Grangé, J.D., additional, Zoulim, F., additional, Fontaine, H., additional, Bertucci, I., additional, Bouvier-Alias, M., additional, Carrat, F., additional, and Benhamou, Y., additional

Published
2015
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25. Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis

Author

Bacq, Y, Sentilhes, L, Reyes, H, Glantz, A, Kondrackiene, J, Binder, T, Nicastri, P, Locatelli, A, Floreani, A, Hernandez, I, Di Martino, V, LOCATELLI, ANNA, Di Martino, V., Bacq, Y, Sentilhes, L, Reyes, H, Glantz, A, Kondrackiene, J, Binder, T, Nicastri, P, Locatelli, A, Floreani, A, Hernandez, I, Di Martino, V, LOCATELLI, ANNA, and Di Martino, V.

Abstract

BACKGROUND & AIMS: We performed a meta-analysis to evaluate the effects of ursodeoxycholic acid (UDCA) on pruritus, liver test results, and outcomes of babies born to women with intrahepatic cholestasis of pregnancy (ICP). METHODS: We performed a systematic review of 9 published, randomized controlled trials (3 double blinded) that compared the effects of UDCA to other drugs, placebo, or no specific treatment (controls) in patients with ICP. We analyzed data from 454 patients: 207 received only UDCA, 70 received only placebo, 42 received cholestyramine, 36 received dexamethasone for 1 week and then placebo for 2 weeks, 65 received S-adenosyl-methionine, and 34 received no specific treatment. To achieve consistency among end points, a standard questionnaire was sent to all corresponding authors. For each end point, we performed pooled analysis that compared the effects of UDCA with those of all controls and UDCA with those of placebos. RESULTS: In pooled analyses that compared UDCA with all controls, UDCA was associated with total resolution of pruritus (odds ratio [OR], 0.23; 95% confidence interval [CI], 0.07-0.74; P < .01), reduced pruritis (OR, 0.27; 95% CI, 0.13-0.55; P < .0001), normalization of serum levels of alanine aminotransferase (ALT) (OR, 0.23; 95% CI, 0.10-0.50; P < .001), decreased serum level of ALT (OR, 0.24; 95% CI, 0.11-0.52; P < .0001), reduced serum levels of bile acids (OR, 0.37; 95% CI, 0.19-0.75; P < .001), fewer premature births (OR, 0.44; 95% CI, 0.24-0.79; P < .01), reduced fetal distress (OR, 0.46; 95% CI, 0.25-0.86; P < .01), less frequent respiratory distress syndrome (OR, 0.30; 95% CI, 0.12-0.74; P < .01), and fewer neonates in the intensive care unit (OR, 0.49; 95% CI, 0.25-0.98; P = .046). In pooled analyses that compared the effects of UDCA with placebo, UDCA reduced pruritus (OR, 0.21; 95% CI, 0.07-0.62; P < .01), normalized (OR, 0.18; 95% CI, 0.06-0.52; P < .001) or decreased serum levels of ALT (

Published
2012

29. 892 URSODEOXYCHOLIC ACID (UDCA) IN THE TREATMENT OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY (ICP): A SYSTEMATIC REVIEW AND META-ANALYSES WITH SPECIFIC ASSESSMENT OF FETAL OUTCOME

Author

Di Martirio, V., primary, Sentilhes, L., additional, Reyes, H.M., additional, Glantz, A., additional, Kondrackiene, J., additional, Binder, T., additional, Nicastri, P.L., additional, Locatelli, A., additional, Floreani, A., additional, Hernandez, I., additional, and Bacq, Y., additional

Published
2011
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44. P1886 Meta-analysis of blood scores for liverfibrosis in chronic hepatitis C

Author

Lunel-Fabiani, F., primary, Calés, P., additional, Halfon, P., additional, Bacq, Y., additional, Leroy, V., additional, Rousselet, M.C., additional, Bourliére, M., additional, de Muret, A., additional, Gallois, Y., additional, Sturm, N., additional, Penaranda, G., additional, Bréchot, M.C., additional, and Trocme, C., additional

Published
2007
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48. CA11 - Nouvelle classification des adénomes hépatocellulaires identifiée par la mise en évidence de corrélations génotype-phénotype

Author

Zucman-Rossi, J., primary, Jeannot, E., additional, Tran Van Nhieu, J., additional, Scoazec, J.Y., additional, Guettier, C., additional, Rebouissou, S., additional, Bacq, Y., additional, Leteurtre, E., additional, Paradis, V., additional, Michalak, S., additional, Wendum, D., additional, Chiche, L., additional, Fabre, M., additional, Laurent, C., additional, Partensky, C., additional, Castain, D., additional, Zafrani, E.S., additional, Laurent-Puig, P., additional, Balabaud, C., additional, and Bioulac-Sage, P., additional

Published
2005
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