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15 results on '"Backhouse, O. C."'

2. Ponatinib Inducing a Panuveitis with Choroidal Effusions and Neurosensory Retinal Detachment in a Patient with Chronic Myeloid Leukaemia.

Author

Patil, A. D., Backhouse, O. C., McGonagle, D., and Bhan, K.

Subjects
*CHRONIC myeloid leukemia, *RETINAL detachment, *EXUDATES & transudates, *IRIDOCYCLITIS, *PROTEIN-tyrosine kinase inhibitors, *CHRONIC leukemia, *VISUAL acuity
Abstract

Case Summary: We present the case of a 50 year old male patient being treated for chronic myeloid leukemia by the tyrosine kinase inhibitor, Ponatinib. After 3 months of treatment, he developed a sight-threatening granulomatous panuveitis in both eyes, with choroidal effusions and neurosensory retinal detachments. Except for a positive interferon-gamma release assay suggesting previous Tuberculosis exposure, all uveitis investigations were normal. Discontinuation of the suspected causative drug led to resolution of signs and a consequent improvement in visual acuity. Conclusion: Ponatinib use may be associated with with a uveitic phenotype that is reminiscent of Harada's disease. We compare and contrast this rare ocular phenomenon with Vogt-Koyanagi-Harada syndrome and discuss a possible immunological basis. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus (vol 38, pg 1242, 2006)

Author

Tarpey, P., Thomas, S., Sarvananthan, N., Mallya, U., Lisgo, S., Talbot, C. J., Roberts, E. O., Awan, M., Surendran, M., McLean, R. J., Reinecke, R. D., Langmann, A., Lindner, S., Koch, M., Jain, S., Woodruff, G., Gale, R. P., Degg, C., Droutsas, K., Asproudis, I., Zubcov, A. A., Pieh, C., Veal, C. D., Machado, R. D., Backhouse, O. C., Baumber, L., Constantinescu, C. S., Brodsky, M. C., Hunter, D. G., Hertle, R. W., Read, R. J., Edkins, S., O'Meara, S., Parker, A., Stevens, C., Teague, J., Wooster, R., Futreal, P. A., Trembath, R. C., Stratton, M. R., Raymond, F. L., Gottlob, I., and Bastawrous, A.

Abstract

Nat Genet

Published
2011

12. Tuberculosis: an under-diagnosed aetiological agent in uveitis with an effective treatment.

Author

Varma, D., Anand, S., Reddy, A. R., Das, A., Watson, J. P., Currie, D. C., Sutcliffe, I., and Backhouse, O. C.

Subjects
TUBERCULOSIS, UVEITIS, DIFFERENTIAL diagnosis, TUBERCULIN test, ANTITUBERCULAR agents, DISEASE risk factors
Abstract

PurposeTo highlight the diversity of clinical presentations with tubercular uveitis in a nonendemic setting, and discuss the diagnostic approach and an effective treatment.MethodDescriptive case series.ResultsA total of 12 cases of varied presentations of tubercular uveitis diagnosed over a period of 1 year of which six cases are described in detail. Presentations included choroidal tuberculomas, multifocal choroiditis, recurrent granulomatous uveitis, panuveitis with cystoid macular oedema, and serpiginous choroiditis. All cases had a chronic or recurrent course and responded very well to antitubercular treatment. Diagnosis was mainly assisted by positive tuberculin testing.ConclusionA high index of suspicion helps diagnose ocular tuberculosis in areas of low prevalence of the disease. It forms part of the differential diagnosis of any chronic or recurrent uveitis, especially in an at-risk patient. Antitubercular treatment seems highly effective.Eye (2006) 20, 1068–1073. doi:10.1038/sj.eye.6702093; published online 7 October 2005 [ABSTRACT FROM AUTHOR]

Published
2006
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13. Medically unexplained visual loss.

Author

Reddy, A. R. and Backhouse, O. C.

Subjects
*LETTERS to the editor, *BLINDNESS
Abstract

A letter to the editor is presented entitled "Medically unexplained visual loss," published within the issue.

Published
2006
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15. Topical chloramphenicol: have GPs cried halt?

Author

Backhouse OC and Metcalfe TW

Subjects
Administration, Topical, England, Family Practice, Health Care Surveys, Humans, Anti-Bacterial Agents administration & dosage, Chloramphenicol administration & dosage, Practice Patterns, Physicians'
Published
1997

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