27 results on '"Backer, Ole De"'
Search Results
2. Impact of gender in patients with device-related thrombosis after left atrial appendage closure -- a sub-analysis from the multicenter EUROC-DRT-registry
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Saw, Jacqueline, primary, Vij, Vivian, additional, Galea, Roberto, additional, Piayda, Kerstin, additional, Nelles, Dominik, additional, Vogt, Lara, additional, Gloekler, Steffen, additional, Fürholz, Monika, additional, Meier, Bernhard, additional, Räber, Lorenz, additional, O'Hara, Gilles, additional, Arzamendi, Dabit, additional, Agudelo, Victor, additional, Asmarats, Lluis, additional, Freixa, Xavier, additional, Flores-Umanzor, Eduardo J, additional, Backer, Ole De, additional, Sondergaard, Lars, additional, Franco, Luis Nombela, additional, Salinas, Pablo, additional, Korsholm, Kasper, additional, Nielsen-Kudsk, Jens Erik, additional, Zeus, Tobias, additional, Operhalski, Felix, additional, Schmidt, Boris, additional, Montalescot, Gilles, additional, Guedeney, Paul, additional, Iriart, Xavier, additional, Miton, Noelie, additional, Gilhofer, Thomas, additional, Fauchier, Laurent, additional, Veliqi, Egzon, additional, Meincke, Felix, additional, Petri, Nils, additional, Nordbeck, Peter, additional, Gonzalez-Ferreiro, Rocio, additional, Cruz-González, Ignacio, additional, L, Deepak Bhatt, additional, Laricchia, Alessandra, additional, Mangieri, Antonio, additional, Omran, Heyder, additional, Schrickel, Jan Wilko, additional, Beiert, Thomas, additional, Rodes-Cabau, Josep, additional, Nickenig, Georg, additional, Sievert, Horst, additional, Sedaghat, Alexander, additional, and Afzal, Shazia, additional
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- 2024
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3. Multimodality imaging for intraprocedural guidance of a transcatheter tricuspid valve replacement.
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Willemen, Yannick, Møller, Jacob E, Nejjari, Mohammed, Linde, Jesper J, Vejlstrup, Niels G, Bardeleben, Ralph S von, Latib, Azeem, Modine, Thomas, and Backer, Ole De
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TRICUSPID valve ,TRANSESOPHAGEAL echocardiography ,AORTIC valve ,COMPUTED tomography ,TREATMENT effectiveness ,HEART valve prosthesis implantation ,CATHETERS ,DICOM (Computer network protocol) ,DIGITAL image processing ,ECHOCARDIOGRAPHY ,FLUOROSCOPY - Published
- 2024
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4. Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial.
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Thyregod, Hans Gustav Hørsted, Jørgensen, Troels Højsgaard, Ihlemann, Nikolaj, Steinbrüchel, Daniel Andreas, Nissen, Henrik, Kjeldsen, Bo Juel, Petursson, Petur, Backer, Ole De, Olsen, Peter Skov, and Søndergaard, Lars
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MYOCARDIAL infarction ,BIOPROSTHETIC heart valves ,AORTIC valve insufficiency ,AORTIC stenosis ,HEART valve prosthesis implantation ,AORTIC valve ,AORTIC valve transplantation ,BIOPROSTHESIS - Abstract
Background and Aims Transcatheter aortic valve implantation (TAVI) has become a viable treatment option for patients with severe aortic valve stenosis across a broad range of surgical risk. The Nordic Aortic Valve Intervention (NOTION) trial was the first to randomize patients at lower surgical risk to TAVI or surgical aortic valve replacement (SAVR). The aim of the present study was to report clinical and bioprosthesis outcomes after 10 years. Methods The NOTION trial randomized 280 patients to TAVI with the self-expanding CoreValve (Medtronic Inc.) bioprosthesis (n = 145) or SAVR with a bioprosthesis (n = 135). The primary composite outcome was the risk of all-cause mortality, stroke, or myocardial infarction. Bioprosthetic valve dysfunction (BVD) was classified as structural valve deterioration (SVD), non-structural valve dysfunction (NSVD), clinical valve thrombosis, or endocarditis according to Valve Academic Research Consortium-3 criteria. Severe SVD was defined as (i) a transprosthetic gradient of 30 mmHg or more and an increase in transprosthetic gradient of 20 mmHg or more or (ii) severe new intraprosthetic regurgitation. Bioprosthetic valve failure (BVF) was defined as the composite rate of death from a valve-related cause or an unexplained death following the diagnosis of BVD, aortic valve re-intervention, or severe SVD. Results Baseline characteristics were similar between TAVI and SAVR: age 79.2 ± 4.9 years and 79.0 ± 4.7 years (P =.7), male 52.6% and 53.8% (P =.8), and Society of Thoracic Surgeons score < 4% of 83.4% and 80.0% (P =.5), respectively. After 10 years, the risk of the composite outcome all-cause mortality, stroke, or myocardial infarction was 65.5% after TAVI and 65.5% after SAVR [hazard ratio (HR) 1.0; 95% confidence interval (CI) 0.7–1.3; P =.9], with no difference for each individual outcome. Severe SVD had occurred in 1.5% and 10.0% (HR 0.2; 95% CI 0.04–0.7; P =.02) after TAVI and SAVR, respectively. The cumulative incidence for severe NSVD was 20.5% and 43.0% (P <.001) and for endocarditis 7.2% and 7.4% (P = 1.0) after TAVI and SAVR, respectively. No patients had clinical valve thrombosis. Bioprosthetic valve failure occurred in 9.7% of TAVI and 13.8% of SAVR patients (HR 0.7; 95% CI 0.4–1.5; P =.4). Conclusions In patients with severe AS and lower surgical risk randomized to TAVI or SAVR, the risk of major clinical outcomes was not different 10 years after treatment. The risk of severe bioprosthesis SVD was lower after TAVR compared with SAVR, while the risk of BVF was similar. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Quality of Life Measures in Aortic Stenosis Research: A Narrative Review.
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Frank, Derk, Kennon, Simon, Bonaros, Nikolaos, Romano, Mauro, Di Mario, Carlo, van Ginkel, Dirk-Jan, Bor, Wilbert, Kasel, Markus, Backer, Ole De, Hachaturyan, Violetta, Lüske, Claudia M., Kurucova, Jana, Bramlage, Peter, and Styra, Rima
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AORTIC stenosis ,QUALITY of life ,OLDER patients ,LIFE expectancy ,HEART failure - Abstract
Background: Elderly patients with aortic stenosis (AS) not only have a reduced life expectancy but also a reduced quality of life (QoL). The benefits of an AS intervention may be considered a balance between a good QoL and a reasonably extended life. However, the different questionnaires being used to determine the QoL were generally not developed for the specific situation of patients with AS and come with strengths and considerable weaknesses. The objective of this article was to provide an overview of the available QoL instruments in AS research, describe their strengths and weaknesses, and provide our assessment of the utility of the available scoring instruments for QoL measurements in AS. Summary: We identified and reviewed the following instruments that are used in AS research: Short Form Health Survey (SF-36/SF-12), EuroQol-5D (EQ-5D), the Illness Intrusiveness Rating Scale (IIRS), the HeartQoL, the Kansas City Cardiomyopathy Questionnaire (KCCQ), the Minnesota Living with Heart Failure Questionnaire (MLHF), the MacNew Questionnaire, and the Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ). Key Messages: There is no standardized assessment of QoL in patients with AS. Many different questionnaires are being used, but they are rarely specific for AS. There is a need for AS-specific research into the QoL of patients as life prolongation may compete for an improved QoL in this elderly patient group. [ABSTRACT FROM AUTHOR]
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- 2023
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6. A notion of bioprosthetic aortic valve durability.
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Thyregod, Hans Gustav Hørsted, Backer, Ole De, and Søndergaard, Lars
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HEART valve prosthesis implantation ,MITRAL valve ,AORTIC valve transplantation ,HEART valves ,OLDER patients - Abstract
The article discusses the 10-year outcomes of the NOTION trial, which compared the durability of transcatheter heart valves (THVs) and surgical aortic valve bioprostheses. The authors acknowledge the small number of patients still alive after 10 years and caution against interpreting the results too broadly. They also mention the importance of cardiac computed tomography (CT) to study leaflet thickening and reduced leaflet motion, although participation in the CT-substudy was low. The authors refute the claim that newer valve designs would necessarily reduce the 10-year mortality rate, citing factors such as age and mortality rates in age-matched populations. They also highlight the lack of evidence for the optimal management of young, low surgical risk patients. The article concludes by disclosing the authors' relationships with relevant companies and acknowledging funding support. [Extracted from the article]
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- 2024
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7. Transcatheter aortic valve-in-valve implantation to treat aortic para-valvular regurgitation after TAVI
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Landes, Uri, primary, Morelli, Olga, additional, Danenberg, Haim, additional, Sathananthan, Janarthanan, additional, Backer, Ole De, additional, Sondergaard, Lars, additional, Abdel-Wahab, Mohamed, additional, Yoon, Sung-Han, additional, Makkar, Raj R., additional, Thiele, Holger, additional, Kim, Won-Keun, additional, Hamm, Christian, additional, Guerrero, Mayra, additional, Rodés-Cabau, Josep, additional, Okuno, Taishi, additional, Pilgrim, Thomas, additional, Mangieri, Antonio, additional, Van Mieghem, Nicolas M., additional, Tchétché, Didier, additional, Schoels, Wolfgang H., additional, Barbanti, Marco, additional, Sinning, Jan-Malte, additional, Ielasi, Alfonso, additional, Tarantini, Giuseppe, additional, De Marco, Federico, additional, Finkelstein, Ariel, additional, Sievert, Horst, additional, Andreas, Martin, additional, Latib, Azeem, additional, Godfrey, Rebecca, additional, Hildick-Smith, David, additional, Manevich, Lisa, additional, Kornowski, Ran, additional, Nazif, Tamim M., additional, Leon, Martin B., additional, and Webb, John G., additional
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- 2022
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8. Residual leaks after transcatheter left atrial appendage closure: why and how to assess it?
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Backer, Ole De and Garot, Philippe
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LEFT heart atrium ,RESIDUAL limbs ,ATRIAL flutter ,PATENT ductus arteriosus ,ATRIAL fibrillation ,IMAGE reconstruction - Abstract
Transcatheter left atrial appendage (LAA) closure is an effective strategy for stroke prevention in patients with non-valvular atrial fibrillation. However, residual leaks around the LAA closure device are common and can increase the risk of thrombo-embolism. A meta-analysis of over 60,000 patients found that any peri-device leak detected by transoesophageal echocardiography (TOE) was present in 1 out of 4 patients and was associated with a higher risk of thrombo-embolism. Peri-device leaks >3 mm and >5 mm were associated with a more than four-fold increase in thrombo-embolic risk. Complete LAA closure should be the goal, and careful pre-procedural planning, co-axial device implantation, and more conformable LAA closure devices can help achieve this. Post-procedural imaging should be performed 2-4 months after LAA closure, and screening for 'LAA patency' at follow-up cardiac CT is not sufficient. Further research is needed to determine the optimal detection method and cut-off values for peri-device leaks. [Extracted from the article]
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- 2024
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9. Orbital atherectomy to facilitate transfemoral transcatheter aortic valve implantation in patients with calcified iliofemoral arteries: a case series.
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Quagliana, Angelo, Montarello, Nicholas J, Vanhaverbeke, Maarten, Willemen, Yannick, Campens, Laurence, Sondergaard, Lars, and Backer, Ole De
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Background The transfemoral (TF) approach drives most of the advantages of transcatheter aortic valve implantation (TAVI) over surgical aortic valve replacement. Alternative accesses for TAVI are associated with higher complication rates, but are still considered in ∼5% of cases due to peripheral arterial disease (PAD). Percutaneous transluminal angioplasty can still allow TF-TAVI in selected cases with severe calcific PAD; however, ancillary techniques for calcium management are often needed. Case Summary Orbital atherectomy was selected to facilitate TF-TAVI in two patients with different degrees and aspects of calcific PAD. Pre-procedural computed tomography analysis was key to choose the most appropriate technique for calcium management. We describe our experience with a step-by-step procedural approach to orbital atherectomy-assisted TF-TAVI. Discussion PAD is not uncommon in patients affected by severe symptomatic aortic valve stenosis. Orbital atherectomy can still allow TF-TAVI in selected cases with severe calcific PAD. A meticulous patient selection and a standardized, step-wise procedural execution are mandatory to optimize outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Transcatheter aortic valve-in-valve implantation to treat aortic para-valvular regurgitation after TAVI
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Landes, Uri, Morelli, Olga, Danenberg, Haim, Sathananthan, Janarthanan, Backer, Ole De, Sondergaard, Lars, Abdel-Wahab, Mohamed, Yoon, Sung Han, Makkar, Raj R., Thiele, Holger, Kim, Won Keun, Hamm, Christian, Guerrero, Mayra, Rodés-Cabau, Josep, Okuno, Taishi, Pilgrim, Thomas, Mangieri, Antonio, Van Mieghem, Nicolas M., Tchétché, Didier, Schoels, Wolfgang H., Barbanti, Marco, Sinning, Jan Malte, Ielasi, Alfonso, Tarantini, Giuseppe, De Marco, Federico, Finkelstein, Ariel, Sievert, Horst, Andreas, Martin, Latib, Azeem, Godfrey, Rebecca, Hildick-Smith, David, Manevich, Lisa, Kornowski, Ran, Nazif, Tamim M., Leon, Martin B., Webb, John G., Landes, Uri, Morelli, Olga, Danenberg, Haim, Sathananthan, Janarthanan, Backer, Ole De, Sondergaard, Lars, Abdel-Wahab, Mohamed, Yoon, Sung Han, Makkar, Raj R., Thiele, Holger, Kim, Won Keun, Hamm, Christian, Guerrero, Mayra, Rodés-Cabau, Josep, Okuno, Taishi, Pilgrim, Thomas, Mangieri, Antonio, Van Mieghem, Nicolas M., Tchétché, Didier, Schoels, Wolfgang H., Barbanti, Marco, Sinning, Jan Malte, Ielasi, Alfonso, Tarantini, Giuseppe, De Marco, Federico, Finkelstein, Ariel, Sievert, Horst, Andreas, Martin, Latib, Azeem, Godfrey, Rebecca, Hildick-Smith, David, Manevich, Lisa, Kornowski, Ran, Nazif, Tamim M., Leon, Martin B., and Webb, John G.
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Background: Para-valvular regurgitation (PVR) after transcatheter aortic valve (TAV) implantation is associated with increased mortality. Redo-TAVI may be applied to treat PVR, yet with unknown efficacy. We thought to assess redo-TAVI efficacy in reducing PVR using the Redo-TAVI registry (45 centers; 600 TAV-in-TAV cases). Methods: Patients were excluded if redo-TAVI was done urgently (N = 253), for isolated TAV stenosis (N = 107) or if regurgitation location at presentation remained undetermined (N = 123). The study group of patients with PVR (N = 70) were compared against patients with intra-valvular regurgitation (IVR) (N = 41). Echocardiographic examinations of 67 (60%) patients were reassessed in a core-lab for data accuracy validation. Results: Core-lab examination validated the jet location in 66 (98.5%) patients. At 30 days, the rate of residual AR ≥ moderate was 7 (10%) in the PVR cohort vs. 1 (2.4%) in the IVR cohort, p = 0.137. The rate of procedural success was 53 (75.7%) vs. 33 (80.5%), p = 0.561; procedural safety 51 (72.8%) vs. 31 (75.6%), p = 0.727; and mortality 2 (2.9%) vs. 1 (2.4%), p = 0.896 at 30 days and 7 (18.6%) vs. 2 (11.5%), p = 0.671 at 1 year, respectively. Of patients with residual PVR ≥ moderate at 30 days, 5/7 occurred after implanting balloon-expandable in self-expanding TAV and 2/7 after balloon-expandable in balloon-expandable TAV. Conclusions: This study puts in perspective redo-TAVI efficacy and limitations to treat PVR after TAVI. Patient selection for this and other therapies for PVR needs further investigation.
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- 2022
11. Clinical Predictors for Procedural Stroke and Implications for Embolic Protection Devices during TAVR:Results from the Multicenter Transcatheter Aortic Valve Replacement In-Hospital Stroke (TASK) Study
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Berkovitch, Anat, Segev, Amit, Maor, Elad, Sedaghat, Alexander, Finkelstein, Ariel, Saccocci, Matteo, Kornowski, Ran, Latib, Azeem, Hernandez, Jose M.De La Torre, Søndergaard, Lars, Mylotte, Darren, Royen, Niels Van, Zaman, Azfar G., Robert, Pierre, Sinning, Jan Malte, Steinvil, Arie, Maisano, Francesco, Orvin, Katia, Iannopollo, Gianmarco, Lee, Dae Hyun, Backer, Ole De, Mercanti, Federico, van der Wulp, Kees, Shome, Joy, Tchétché, Didier, Barbash, Israel M., Berkovitch, Anat, Segev, Amit, Maor, Elad, Sedaghat, Alexander, Finkelstein, Ariel, Saccocci, Matteo, Kornowski, Ran, Latib, Azeem, Hernandez, Jose M.De La Torre, Søndergaard, Lars, Mylotte, Darren, Royen, Niels Van, Zaman, Azfar G., Robert, Pierre, Sinning, Jan Malte, Steinvil, Arie, Maisano, Francesco, Orvin, Katia, Iannopollo, Gianmarco, Lee, Dae Hyun, Backer, Ole De, Mercanti, Federico, van der Wulp, Kees, Shome, Joy, Tchétché, Didier, and Barbash, Israel M.
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Background: Data to support the routine use of embolic protection devices for stroke prevention during transcatheter aortic valve replacement (TAVR) are controversial. Identifying patients at high risk for peri-procedural cerebrovascular events may facilitate effective patient selection for embolic protection devices during TAVR. Aim: To generate a risk score model for stratifying TAVR patients according to peri-procedural cerebrovascular events risk. Methods and results: A total of 8779 TAVR patients from 12 centers worldwide were included. Peri-procedural cerebrovascular events were defined as an ischemic stroke or a transient ischemic attack occurring ≤24 h from TAVR. The peri-procedural cerebrovascular events rate was 1.4% (n = 127), which was independently associated with 1-year mortality (hazards ratio (HR) 1.78, 95% confidence interval (CI) 1.06–2.98, p < 0.028). The TASK risk score parameters were history of stroke, use of a non-balloon expandable valve, chronic kidney disease, and peripheral vascular disease, and each parameter was assigned one point. Each one-point increment was associated with a significant increase in peri-procedural cerebrovascular events risk (OR 1.96, 95% CI 1.56–2.45, p < 0.001). The TASK score was dichotomized into very-low, low, intermediate, and high (0, 1, 2, 3–4 points, respectively). The high-risk TASK score group (OR 5.4, 95% CI 2.06–14.16, p = 0.001) was associated with a significantly higher risk of peri-procedural cerebrovascular events compared with the low TASK score group. Conclusions: The proposed novel TASK risk score may assist in the pre-procedural risk stratification of TAVR patients for peri-procedural cerebrovascular events.
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- 2022
12. NUDF:Neural Unsigned Distance Fields for High Resolution 3D Medical Image Segmentation
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Sorensen, Kristine, Camara, Oscar, Backer, Ole De, Kofoed, Klaus F., Paulsen, Rasmus R., Sorensen, Kristine, Camara, Oscar, Backer, Ole De, Kofoed, Klaus F., and Paulsen, Rasmus R.
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Medical image segmentation is often considered as the task of labelling each pixel or voxel as being inside or outside a given anatomy. Processing the images at their original size and resolution often result in insuperable memory requirements, but downsampling the images leads to a loss of important details. Instead of aiming to represent a smooth and continuous surface in a binary voxel-grid, we propose to learn a Neural Unsigned Distance Field (NUDF) directly from the image. The small memory requirements of NUDF allow for high resolution processing, while the continuous nature of the distance field allows us to create high resolution 3D mesh models of shapes of any topology (i.e. open surfaces). We evaluate our method on the task of left atrial appendage (LAA) segmentation from Computed Tomography (CT) images. The LAA is a complex and highly variable shape, being thus difficult to represent with traditional segmentation methods using discrete labelmaps. With our proposed method, we are able to predict 3D mesh models that capture the details of the LAA and achieve accuracy in the order of the voxel spacing in the CT images.
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- 2022
13. Treatment of late paravalvular regurgitation after transcatheter aortic valve implantation: prognostic implications.
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Landes, Uri, Hochstadt, Aviram, Manevich, Lisa, Webb, John G, Sathananthan, Janarthanan, Sievert, Horst, Piayda, Kerstin, Leon, Martin B, Nazif, Tamim M, Blusztein, David, Hildick-Smith, David, Pavitt, Chris, Thiele, Holger, Abdel-Wahab, Mohamed, Mieghem, Nicolas M Van, Adrichem, Rik, Sondergaard, Lars, Backer, Ole De, Makkar, Raj R, and Koren, Ofir
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HEART valve prosthesis implantation ,PROGNOSIS ,PATIENT selection ,PERCUTANEOUS balloon valvuloplasty - Abstract
Aims Paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI) is associated with increased morbidity and mortality. The effect of transcatheter interventions to treat PVR after the index TAVI was investigated. Methods and results A registry of consecutive patients who underwent transcatheter intervention for ≥ moderate PVR after the index TAVI at 22 centers. The principal outcomes were residual aortic regurgitation (AR) and mortality at 1 year after PVR treatment. A total of 201 patients were identified: 87 (43%) underwent redo-TAVI, 79 (39%) plug closure, and 35 (18%) balloon valvuloplasty. Median TAVI-to-re-intervention time was 207 (35; 765) days. The failed valve was self-expanding in 129 (63.9%) patients. The most frequent devices utilized were a Sapien 3 valve for redo-TAVI (55, 64%), an AVP II as plug (33, 42%), and a True balloon for valvuloplasty (20, 56%). At 30 days, AR ≥ moderate persisted in 33 (17.4%) patients: 8 (9.9%) after redo-TAVI, 18 (25.9%) after plug, and 7 (21.9%) after valvuloplasty (P = 0.036). Overall mortality was 10 (5.0%) at 30 days and 29 (14.4%) at 1 year: 0, 8 (10.1%), and 2 (5.7%) at 30 days (P = 0.010) and 11 (12.6%), 14 (17.7%), and 4 (11.4%) at 1 year (P = 0.418), after redo-TAVI, plug, and valvuloplasty, respectively. Regardless of treatment strategy, patients in whom AR was reduced to ≤ mild had lower mortality at 1 year compared with those with AR persisting ≥ moderate [11 (8.0%) vs. 6 (21.4%); P = 0.007]. Conclusion This study describes the efficacy of transcatheter treatments for PVR after TAVI. Patients in whom PVR was successfully reduced had better prognosis. The selection of patients and the optimal PVR treatment modality require further investigation. [ABSTRACT FROM AUTHOR]
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- 2023
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14. NUDF: Neural Unsigned Distance Fields for High Resolution 3D Medical Image Segmentation
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Sorensen, Kristine, primary, Camara, Oscar, additional, Backer, Ole de, additional, Kofoed, Klaus F., additional, and Paulsen, Rasmus R., additional
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- 2022
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15. 90 Annular size and interaction with trans-catheter aortic valves for the treatment of severe bicuspid aortic valve stenosis: insights from the beat registry
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Moscarella, Elisabetta, primary, Mangieri, Antonio, additional, Giannini, Francesco, additional, Tchetchè, Didier, additional, Kim, Won-keun, additional, Sinning, Jan Malte, additional, Landes, Uri, additional, Kornowski, Ran, additional, Backer, Ole De, additional, Nickenig, George, additional, Biase, Chiara De, additional, Soendergaard, Lars, additional, Marco, Federico De, additional, Bedogni, Francesco, additional, Ancona, Marco, additional, Montorfano, Matteo, additional, Regazzoli, Damiano, additional, Stefanini, Giulio, additional, Toggweiler, Stefan, additional, Tamburino, Corrado, additional, Immè, Sebastiano, additional, Tarantini, Giuseppe, additional, Sievert, Horst, additional, Schaefer, Ulrich, additional, Kempfert, Jörg, additional, Woehrle, Jochen, additional, Latib, Azeem, additional, Calabrò, Paolo, additional, Medda, Massimo, additional, Tespili, Maurizio, additional, Colombo, Antonio, additional, and Ielasi, Alfonso, additional
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- 2021
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16. 680 Peripheral intravascular lithotripsy of ILEO-femoral arteries to facilitate transfemoral TAVI: a multicentric prospective registry
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Nardi, Giulia, primary, Backer, Ole De, additional, Saia, Francesco, additional, Sondergaard, Lars, additional, Ristalli, Francesca, additional, Meucci, Francesco, additional, Stolcova, Miroslava, additional, Mattesini, Alessio, additional, Demola, Pierluigi, additional, Wang, Christina Xi, additional, Jabri, Anees Al, additional, Bruno, Antonio Giulio, additional, Palmierini, Tullio, additional, Ielasi, Alfonso, additional, Belle, Eric Van, additional, Berti, Sergio, additional, and Mario, Carlo Di, additional
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- 2021
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17. Percutaneous vs. surgical axillary access for transcatheter aortic valve implantation: the TAXI registry.
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GIORDANO, Arturo, SCHAEFER, Andreas, BHADRA, Oliver D., CONRADI, Lenard, WESTERMANN, Dirk, BACKER, Ole DE, BAJORAS, Vilhelmas, SONDERGAARD, Lars, QURESHI, Waqas T., KAKOUROS, Nikolaos, ALDRUGH, Summer, AMAT-SANTOS, Ignacio, MARTÍNEZ, Sandra SANTOS, KANEKO, Tsuyoshi, HARLOFF, Morgan, TELES, Rui, NOLASCO, Tiago, NEVES, Jose P., ABECASIS, Miguel, and WERNER, Nikos
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- 2022
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18. Combined surgical and catheter-based treatment of extensive thoracic aortic aneurysm and aortic valve stenosis
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Backer, Ole De, Lönn, Lars, and Sndergaard, Lars
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- 2015
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19. TCT CONNECT-86 Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience
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Armario, Xavier, primary, Rosseel, Liesbeth, additional, Kharbanda, Rajesh, additional, Khogali, Saib, additional, Abdel-Wahab, Mohamed, additional, Van Mieghem, Nicolas, additional, Tchetche, Didier, additional, Dumonteil, Nicolas, additional, Backer, Ole De, additional, Cotton, James, additional, McGrath, Brian, additional, Balakrishnan, Deepu, additional, Ali, Noman, additional, Farhan, Serdar, additional, Joseph, Jubin, additional, Charbonnier, Gaétan, additional, Okuno, Taishi, additional, McHugh, Fiachra, additional, Hildick-Smith, David, additional, Gilgen, Nicole, additional, Frerker, Christian, additional, Angelillis, Marco, additional, Grygier, Marek, additional, Cockburn, James, additional, Bjursten, Henrik, additional, Teles, Rui, additional, Petronio, Anna Sonia, additional, Pilgrim, Thomas, additional, Sinning, Jan-Malte, additional, Nickenig, Georg, additional, Sondergaard, Lars, additional, and Mylotte, Darren, additional
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- 2020
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20. Deep Learning Framework for Real-Time Estimation of in-silico Thrombotic Risk Indices in the Left Atrial Appendage.
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Ferez, Xabier Morales, Mill, Jordi, Juhl, Kristine Aavild, Acebes, Cesar, Iriart, Xavier, Legghe, Benoit, Cochet, Hubert, Backer, Ole De, Paulsen, Rasmus R., and Camara, Oscar
- Abstract
Patient-specific computational fluid dynamics (CFD) simulations can provide invaluable insight into the interaction of left atrial appendage (LAA) morphology, hemodynamics, and the formation of thrombi in atrial fibrillation (AF) patients. Nonetheless, CFD solvers are notoriously time-consuming and computationally demanding, which has sparked an ever-growing body of literature aiming to develop surrogate models of fluid simulations based on neural networks. The present study aims at developing a deep learning (DL) framework capable of predicting the endothelial cell activation potential (ECAP), an in-silico index linked to the risk of thrombosis, typically derived from CFD simulations, solely from the patient-specific LAA morphology. To this end, a set of popular DL approaches were evaluated, including fully connected networks (FCN), convolutional neural networks (CNN), and geometric deep learning. While the latter directly operated over non-Euclidean domains, the FCN and CNN approaches required previous registration or 2D mapping of the input LAA mesh. First, the superior performance of the graph-based DL model was demonstrated in a dataset consisting of 256 synthetic and real LAA, where CFD simulations with simplified boundary conditions were run. Subsequently, the adaptability of the geometric DL model was further proven in a more realistic dataset of 114 cases, which included the complete patient-specific LA and CFD simulations with more complex boundary conditions. The resulting DL framework successfully predicted the overall distribution of the ECAP in both datasets, based solely on anatomical features, while reducing computational times by orders of magnitude compared to conventional CFD solvers. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Transcatheter aortic valve implantation in Denmark
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Jørgensen, Troels Højsgaard, Backer, Ole De, Nissen, Henrik, Terkelsen, Christian Juhl, Mortensen, Poul Erik, Klaaborg, Kaj-Erik, Aarøe, Jens, Christiansen, Evald Høj, and Søndergaard, Lars
- Abstract
During the latest decade, transcatheter aortic valve implantation (TAVI) has evolved from being indicated only in patients with severe aortic stenosis and prohibitive or high surgical risk, to be an alternative to surgical aortic valve replacement in patients with intermediate surgical risk. Improvements of the peri-procedural management have resulted in marked reduction of complications and an increasing number of patients treated with TAVI every year in Denmark. By a minimalist approach, TAVI can be performed in local anesthaesia, with same day mobilisation and discharge within few days, without affecting the safety.
- Published
- 2018
22. Late presentation of left atrial appendage erosion and perforation by an Amplatzer™ Amulet™ closure device: a case report.
- Author
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Wilkins, Ben, Carranza, Christian L, Søndergaard, Lars, and Backer, Ole De
- Subjects
CARDIAC surgery ,ATRIAL fibrillation ,CARDIAC tamponade ,HEART diseases ,SYNCOPE - Abstract
Background Percutaneous left atrial appendage (LAA) closure may reduce the risk of cardioembolic stroke in patients with non-valvular atrial fibrillation. Given the prophylactic nature of the procedure, identifying and managing complications are paramount. Case summary A 73-year-old man presented 14 months after percutaneous LAA closure with syncope and acute pericardial tamponade which required surgical exploration and haemostasis; the most temporally remote account of this complication albeit amongst very few case reports. Tissue erosion by the Amplatzer™ Amulet™ LAA closure device (Abbott, Plymouth, MN, USA) was noted at two separate anatomical locations, corresponding to the device disc and lobe, which has not been described previously. Discussion This case report highlights the anatomical relationship between the LAA and its surrounding structures, and the importance of recognizing the risk of late device erosion. [ABSTRACT FROM AUTHOR]
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- 2020
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23. A comparative study of different imaging modalities for successful percutaneous left atrial appendage closure
- Author
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Chow, Danny HF, primary, Bieliauskas, Gintautas, additional, Sawaya, Fadi J, additional, Millan-Iturbe, Oscar, additional, Kofoed, Klaus F, additional, Søndergaard, Lars, additional, and Backer, Ole De, additional
- Published
- 2017
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24. Incidence and outcome of peri-procedural transcatheter heart valve embolization and migration: the TRAVEL registry (TranscatheteR HeArt Valve EmboLization and Migration).
- Author
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Kim, Won-Keun, Schäfer, Ulrich, Tchetche, Didier, Nef, Holger, Arnold, Martin, Avanzas, Pablo, Rudolph, Tanja, Scholtz, Smita, Barbanti, Marco, Kempfert, Jörg, Mangieri, Antonio, Lauten, Alexander, Frerker, Christian, Yoon, Sung-Han, Holzamer, Andreas, Praz, Fabien, Backer, Ole De, Toggweiler, Stefan, Blumenstein, Johannes, and Purita, Paola
- Abstract
Aims Peri-procedural transcatheter valve embolization and migration (TVEM) is a rare but potentially devastating complication of transcatheter aortic valve implantation (TAVI). We sought to assess the incidence, causes, and outcome of TVEM in a large multicentre cohort. Methods and results We recorded cases of peri-procedural TVEM in patients undergoing TAVI between January 2010 and December 2017 from 26 international sites. Peri-procedural TVEM occurred in 273/29 636 (0.92%) TAVI cases (age 80.8 ± 7.3 years; 53.8% female), of which 217 were to the ascending aorta and 56 to the left ventricle. The use of self-expanding or first-generation prostheses and presence of a bicuspid aortic valve were independent predictors of TVEM. Bail-out measures included repositioning attempts using snares or miscellaneous tools (41.0%), multiple valve implantations (83.2%), and conversion to surgery (19.0%). Using 1:4-propensity matching, we identified a cohort of 235 patients with TVEM (TVEM
PS ) and 932 patients without TVEM (non-TVEMPS ). In the matched cohort, all-cause mortality was higher in TVEMPS than in non-TVEMPS at 30 days (18.6% vs. 4.9%; P < 0.001) and after 1 year (30.5% vs. 16.6%; P < 0.001). Major stroke was more frequent in TVEMPS at 30 days (10.6% vs. 2.8%; P < 0.001), but not at 1 year (4.6% vs. 1.9%; P = 0.17). The need for emergent cardiopulmonary support, major stroke at 30 days, and acute kidney injury Stages 2 and 3 increased the risk of 1-year mortality, whereas a better renal function at baseline was protective. Conclusion Transcatheter valve embolization and migration occurred in approximately 1% and was associated with increased morbidity and mortality. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR]- Published
- 2019
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25. Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI: an observational comparative study
- Author
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Ratcovich, Hanna, primary, Biasco, Luigi, primary, Pedersen, Frants, primary, Helqvist, Steffen, primary, Saunamaki, Kari, primary, Tilsted, Hans-Henrik, primary, Clemmensen, Peter, primary, Olivecrona, Goran, primary, Kelbaek, Henning, primary, Jørgensen, Erik, primary, Engstrøm, Thomas, primary, Holmvang, Lene, primary, and Backer, Ole De, additional
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- 2015
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26. Combined surgical and catheter‐based treatment of extensive thoracic aortic aneurysm and aortic valve stenosis
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Backer, Ole De, primary, Lönn, Lars, additional, and Søndergaard, Lars, additional
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- 2014
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27. Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI: an observational comparative study
- Author
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Backer, Ole De, Ratcovich, Hanna, Biasco, Luigi, Pedersen, Frants, Helqvist, Steffen, Saunamaki, Kari, Tilsted, Hans-Henrik, Clemmensen, Peter, Olivecrona, Goran, Kelbaek, Henning, Jørgensen, Erik, Engstrøm, Thomas, and Holmvang, Lene
- Published
- 2015
- Full Text
- View/download PDF
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