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2. EuroGuiderm guideline on lichen sclerosus—Treatment of lichen sclerosus.

Author

Kirtschig, G., Kinberger, M., Kreuter, A., Simpson, R., Günthert, A., van Hees, C., Becker, K., Ramakers, M. J., Corazza, M., Müller, S., von Seitzberg, S., Boffa, M. J., Stein, R., Barbagli, G., Chi, C. C., Dauendorffer, J. N., Fischer, B., Gaskins, M., Hiltunen‐Back, E., and Höfinger, A.

Subjects
CONSCIOUSNESS raising, LICHEN sclerosus et atrophicus, RARE diseases, DISEASE risk factors, SKIN diseases
Abstract

Introduction: Lichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness; it may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are usually a whitening of the genital skin, sometimes preceded by redness and oedema; fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early. Objectives: The guideline intends to provide guidance on the diagnostic of LS (part 1), highlight important aspects in the care of LS patients, generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow‐up of patients with LS and inform about new developments and potential research aspects. Materials and Methods: The guideline was developed in accordance with the EuroGuiDerm Methods Manual v1.3https://www.edf.one/de/home/Guidelines/EDF‐EuroGuiDerm.html. The wording of the recommendations was standardized (as suggested by the GRADE Working Group). The guideline development group is comprised of 34 experts from 16 countries, including 5 patient representatives. Results: Ultrapotent or potent topical corticosteroids in females and males, adults and children remain gold standard of care for genital LS; co‐treatment with emollients is recommended. If standard treatment fails in males, a surgical intervention is recommended, complete circumcision may cure LS in males. UV light treatment is recommended for extragenital LS; however, there is limited scientific evidence. Topical calcineurin inhibitors are second line treatment. Laser treatment, using various wave lengths, is under investigation, and it can currently not be recommended for the treatment of LS. Treatment with biologics is only reported in single cases. Conclusions: LS has to be diagnosed and treated as early as possible in order to minimize sequelae like scarring and cancer development. Topical potent and ultrapotent corticosteroids are the gold standard of care; genital LS is often a lifelong disease and needs to be treated long‐term. [ABSTRACT FROM AUTHOR]

Published
2024
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3. EuroGuiderm guideline on lichen sclerosus—introduction into lichen sclerosus.

Author

Kirtschig, G., Kinberger, M., Kreuter, A., Simpson, R., Günthert, A., van Hees, C., Becker, K., Ramakers, M. J., Corazza, M., Müller, S., von Seitzberg, S., Boffa, M. J., Stein, R., Barbagli, G., Chi, C. C., Dauendorffer, J. N., Fischer, B., Gaskins, M., Hiltunen‐Back, E., and Höfinger, A.

Subjects
CONSCIOUSNESS raising, LICHEN sclerosus et atrophicus, RARE diseases, DISEASE risk factors, SKIN diseases
Abstract

Introduction: Lichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness. It may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are redness and oedema, typically followed by whitening of the genital skin; sometimes fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early. Objectives: The guideline intends to provide guidance on the diagnostic of LS, highlight important aspects in the care of LS patients (part 1), generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow‐up of patients with LS and inform about new developments and potential research aspects. Materials and Methods: The guideline was developed in accordance with the EuroGuiDerm Methods Manual v1.3https://www.edf.one/de/home/Guidelines/EDF‐EuroGuiDerm.html. The wording of the recommendations was standardized (as suggested by the GRADE Working Group). The guideline development group is comprised of 34 experts from 16 countries, including 5 patient representatives. Results: Ultrapotent or potent topical corticosteroids in females and males, adults and children remain gold standard of care for genital LS; co‐treatment with emollients is recommended. If standard treatment fails in males, a surgical intervention is recommended, complete circumcision may cure LS in males. UV light treatment is recommended for extragenital LS; however, there is limited scientific evidence. Topical calcineurin inhibitors are second line treatment. Laser treatment, using various wave lengths, is under investigation, and it can currently not be recommended for the treatment of LS. Treatment with biologics is only reported in single cases. Conclusions: LS has to be diagnosed and treated as early as possible in order to minimize sequelae like scarring and cancer development. Topical potent and ultrapotent corticosteroids are the gold standard of care; genital LS is often a lifelong disease and needs to be treated long‐term. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Vitamin B12

Author

Back, E., Biesalski, H. K., Offermanns, Stefan, editor, and Rosenthal, Walter, editor

Published
2008
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12. Folic Acid

Author

Back, E., Biesalski, H. K., Offermanns, Stefan, editor, and Rosenthal, Walter, editor

Published
2008
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13. Vitamin C

Author

Back, E., Biesalski, H. K., Offermanns, Stefan, editor, and Rosenthal, Walter, editor

Published
2008
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15. Niacin

Author

Back, E., Biesalski, H. K., Offermanns, Stefan, editor, and Rosenthal, Walter, editor

Published
2008
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17. Permanent stoma rates after anterior resection for rectal cancer : risk prediction scoring using preoperative variables

Author

Back, E., Häggström, J., Holmgren, K., Haapamäki, M. M., Matthiessen, Peter, Rutegård, J., Rutegård, M., Back, E., Häggström, J., Holmgren, K., Haapamäki, M. M., Matthiessen, Peter, Rutegård, J., and Rutegård, M.

Abstract

BACKGROUND: A permanent stoma after anterior resection for rectal cancer is common. Preoperative counselling could be improved by providing individualized accurate prediction modelling. METHODS: Patients who underwent anterior resection between 2007 and 2015 were identified from the Swedish Colorectal Cancer Registry. National Patient Registry data were added to determine presence of a stoma 2 years after surgery. A training set based on the years 2007-2013 was employed in an ensemble of prediction models. Judged by the area under the receiving operating characteristic curve (AUROC), data from the years 2014-2015 were used to evaluate the predictive ability of all models. The best performing model was subsequently implemented in typical clinical scenarios and in an online calculator to predict the permanent stoma risk. RESULTS: Patients in the training set (n = 3512) and the test set (n = 1136) had similar permanent stoma rates (13.6 and 15.2 per cent). The logistic regression model with a forward/backward procedure was the most parsimonious among several similarly performing models (AUROC 0.67, 95 per cent c.i. 0.63 to 0.72). Key predictors included co-morbidity, local tumour category, presence of metastasis, neoadjuvant therapy, defunctioning stoma use, tumour height, and hospital volume; the interaction between age and metastasis was also predictive. CONCLUSION: Using routinely available preoperative data, the stoma outcome at 2 years after anterior resection for rectal cancer can be predicted fairly accurately., Funding agency:Cancer Research Foundation in Northern Sweden

Published
2021
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19. White flies injurious to citrus in Florida /

Author

Morrill, A. W. (Austin Winfield), 1880-1954, Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, Morrill, A. W. (Austin Winfield), 1880-1954, and Back, E. A. (Ernest Adna), 1886

Subjects
Aleyrodidae, Citrus, Diseases and pests, Florida
Published
1911

20. Natural control of white flies in Florida /

Author

Morrill, A. W. (Austin Winfield), 1880-1954, Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, Morrill, A. W. (Austin Winfield), 1880-1954, and Back, E. A. (Ernest Adna), 1886

Subjects
Aleyrodidae
Published
1912

21. The melon fly /

Author

Back, E. A. (Ernest Adna), 1886, Pemberton, C. E. (Cyril Eugene), 1886, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Pemberton, C. E. (Cyril Eugene), 1886

Subjects
Melon fly
Published
1918

22. The cadelle /

Author

Back, E. A. (Ernest Adna), 1886, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Cotton, R. T.

Subjects
Diseases and pests, Grain
Published
1926

23. Red cedar chests as protectors against moth damage /

Author

Back, E. A. (Ernest Adna), 1886, Rabak, Frank, 1881, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Rabak, Frank, 1881

Subjects
Cedar, Chests, Clothes moths, Control
Published
1922

24. House ants /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Ants, Insect pests
Published
1938

25. House ants. /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Ants
Published
1946

26. Cockroaches and their control,

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Cockroaches
Published
1937

27. Carpet beetles.

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Beetles
Published
1938

28. The Mediterranean fruit fly in Bermuda /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Bermuda Islands, Diseases and pests, Fruit, Mediterranean fruit-fly
Published
1914

29. The Mediterranean fruit fly in Hawaii /

Author

Back, E. A. (Ernest Adna), 1886, Pemberton, C. E. (Cyril Eugene), 1886, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Pemberton, C. E. (Cyril Eugene), 1886

Subjects
Diseases and pests, Fruit, Hawaii, Mediterranean fruit-fly
Published
1918

30. The melon fly in Hawaii /

Author

Back, E. A. (Ernest Adna), 1886, Pemberton, C. E. (Cyril Eugene), 1886, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Pemberton, C. E. (Cyril Eugene), 1886

Subjects
Agricultural pests, Diseases and pests, Hawaii, Melon fly, Muskmelon
Published
1917

31. House ants /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Ants
Published
1937

32. Insect control in flour mills /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Control, Flour mills, Fumigation, Insect pests
Published
1920

33. Industrial fumigation against insects /

Author

Back, E. A. (Ernest Adna), 1886, Cotton, R. T., United States. Department of Agriculture, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, Cotton, R. T., and United States. Department of Agriculture

Subjects
Buildings, Control, Flour mills, Food storage pests, Fumigation, Insect pests
Published
1942

34. Industrial fumigation against insects /

Author

Back, E. A. (Ernest Adna), 1886, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Cotton, R. T.

Subjects
Buildings, Control, Flour mills, Food storage pests, Fumigation, Insect pests
Published
1935

35. Cockroaches and their control /

Author

Back, E. A. (Ernest Adna), 1886, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1886

Subjects
Cockroaches
Published
1939

36. Industrial fumigation against insects /

Author

Back, E. A. (Ernest Adna), 1886, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Cotton, R. T.

Subjects
Buildings, Control, Flour mills, Food storage pests, Fumigation, Insect pests
Published
1937

39. The granary weevil /

Author

Back, E. A. (Ernest Adna), 1886, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1886, and Cotton, R. T.

Subjects
Diseases and injuries, Grain, Granary weevil, Storage
Published
1926

40. The granary weevil

Author

Back, E. A. (Ernest Adna), 1880-1959, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1880-1959, and Cotton, R. T.

Subjects
Diseases and injuries, Grain, Granary weevil, Storage

42. The cadelle

Author

Back, E. A. (Ernest Adna), 1880-1959, Cotton, R. T., U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1880-1959, and Cotton, R. T.

Subjects
Diseases and pests, Grain

43. The melon fly

Author

Back, E. A. (Ernest Adna), 1880-1959, Pemberton, C. E. (Cyril Eugene), 1886, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1880-1959, and Pemberton, C. E. (Cyril Eugene), 1886

Subjects
Melon fly

44. Red cedar chests as protectors against moth damage

Author

Back, E. A. (Ernest Adna), 1880-1959, Rabak, Frank, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1880-1959, and Rabak, Frank

Subjects
Cedar, Chests, Clothes moths, Control

45. Cockroaches and their control

Author

Back, E. A. (Ernest Adna), 1880-1959, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1880-1959

Subjects
Cockroaches

46. Carpet beetles

Author

Back, E. A. (Ernest Adna), 1880-1959, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1880-1959

Subjects
Beetles

47. House ants

Author

Back, E. A. (Ernest Adna), 1880-1959, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1880-1959

Subjects
Ants

48. House ants

Author

Back, E. A. (Ernest Adna), 1880-1959, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1880-1959

Subjects
Ants

49. Cockroaches and their control

Author

Back, E. A. (Ernest Adna), 1880-1959, U.S. Department of Agriculture, National Agricultural Library, and Back, E. A. (Ernest Adna), 1880-1959

Subjects
Cockroaches

50. The melon fly in Hawaii

Author

Back, E. A. (Ernest Adna), 1880-1959, Pemberton, C. E. (Cyril Eugene), 1886, U.S. Department of Agriculture, National Agricultural Library, Back, E. A. (Ernest Adna), 1880-1959, and Pemberton, C. E. (Cyril Eugene), 1886

Subjects
Agricultural pests, Diseases and pests, Hawaii, Melon fly, Muskmelon

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