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This study aimed to evaluate the effects of different starch sources on the extrusion process, kibble characteristics and diet palatability for dogs. Seven diets with corn, brown rice, sorghum, potato starch, sweet potato flour, chickpea and pea as the only starch source were evaluated. The dietary inclusion of the starch sources varied between 330.13 and 643.84 g/kg to provide similar starch concentrations in all diets (around 300 g/kg). The conditioning temperature and the volume of water added to the preconditioner during the processing of the diets were measured, and the extruder variables evaluated were knife speed, feed rate, screw speed, amperage and productivity. For the physical characteristics of kibbles, density, size, expansion index and hardness were measured. Porosity variables evaluated were total pore area, average pore area and number of pores. Diet palatability was evaluated in 16 dogs. Six paired palatability tests were performed, in which all diets were compared to the corn diet, with two consecutive days per test, totalling 32 repetitions (16 dogs × 2 days/test). Diets with tubers presented lower kibble density and higher size, expansion index and hardness than the diets with cereals and pulses (p

O artigo objetiva analisar as ações promovidas, no âmbito do Programa Veredas Formativas, com vistas ao desenvolvimento profissional dos professores de Educação Infantil ingressantes na Rede Municipal de Ensino de Curitiba (Paraná/Brasil), no período de 2019 a 2021. A Secretaria Municipal da Educação de Curitiba operacionaliza o Programa Veredas Formativas oportunizando a participação dos sujeitos da educação em ações que contribuem para o seu desenvolvimento profissional e, dentre essas, insere-se o Curso para Professores Iniciantes da Educação Infantil que é ofertado aos docentes recém-contratados que passam por formação específica, em momento anterior à estreia em sala de aula, abrangendo temáticas relacionadas às atribuições profissionais e às articulações pedagógicas e administrativas vinculadas ao trabalho docente, bem como ao reconhecimento da legislação e ampliação cultural. De abordagem qualitativa, a pesquisa configura-se como descritiva pautada pela análise bibliográfica e documental, sendo revisitados autores que discutem a temática do desenvolvimento profissional docente como Marcelo (1999), Marcelo e Vaillant (2009; 2012), Tardif (2009), Imbernón (2010), André (2018) dentre outros e, também, os documentos como as Diretrizes Curriculares Nacionais para a Educação Infantil (Brasil, 2010), a Base Nacional Comum Curricular (Brasil, 2018), o Currículo da Educação Infantil: Diálogos com a BNCC (Curitiba, 2020), o Programa Veredas Formativas (Curitiba, 2021), entre outros. Considera-se que a proposição de um curso específico visando o desenvolvimento profissional é efetiva pois os docentes iniciantes têm a oportunidade de ampliar: o conhecimento sobre a proposta pedagógica da Educação Infantil; a compreensão dos aspectos administrativos e organizativos do cotidiano de atuação pedagógica, assim como o repertório cultural e pessoal.

As pesquisas acadêmicas possibilitam reflexões e soluções inovadoras, sendo de grande importância que essas dialoguem com a vida social, seja para observar as demandas existentes, seja para aplicar seus produtos. Uma das ligações se dá entre o ambiente acadêmico e o ambiente profissional na conexão entre habilidades profissionais e a pesquisa científica. Este estudo analisa a produção de um periódico de caráter científico e formativo, focando na integração entre teoria e prática no contexto educacional de uma rede municipal de ensino. Para tanto, utiliza-se a Análise Temática de Minayo (2008), o estudo se baseia nas teorias de Kuhn (2011) e Latour (2000) sobre o avanço científico e na importância do elo entre pesquisa e prática profissional, conforme preconizado pela UNESCO (2010). O artigo destaca a relevância da conexão entre pesquisa e prática e a aplicação desta concepção, exemplificada pela Revista Veredas da Secretaria Municipal da Educação de Curitiba, investiga-se seu sistema de avaliação e ações voltadas à esse propósito.

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As the complexity and integration of electronic devices increase, understanding and mitigating side-channel vulnerabilities will remain a critical area of cybersecurity research. The new and intriguing software-based thermal side-channel attacks and countermeasures use thermal emissions from a device to extract or defend sensitive information, by reading information from the built-in thermal sensors via software. This work extends the Hot-n-Cold anomaly detection technique, applying it in circumstances much closer to the real-world computational environments by detecting irregularities in the Linux command behavior through CPU temperature monitoring. The novelty of this approach lies in the introduction of five types of noise across the CPU, including moving files, performing extended math computations, playing songs, and browsing the web while the attack detector is running. We employed Hot-n-Cold to monitor core temperatures on three types of CPUs utilizing two commonly used Linux terminal commands, ls and chmod. The results show a high correlation, approaching 0.96, between the original Linux command and a crafted command, augmented with vulnerable system calls. Additionally, a Machine Learning algorithm was used to classify whether a thermal trace is augmented or not, with an accuracy of up to 88%. This research demonstrates the potential for detecting attacks through thermal sensors even when there are different types of noise in the CPU, simulating a real-world scenario.

Although ovarian cystic teratoma is the most common ovarian tumor, complications are quite rare. However, it is important to be recognized by the radiologist in order to avoid inaccurately diagnosing them as malignant lesions. This case report describes a 61-year-old postmenopausal woman, who presented to the emergency room with abdominal pain following a minor blunt abdominal trauma. In this context, a CT scan was performed, which showed the presence of round, hypodense masses randomly distributed in the peritoneum, with coexisting ascites in moderate amount; ovarian carcinoma with peritoneal carcinomatosis was suspected. The patient was hospitalized and an MRI of the abdomen and pelvis was recommended for a more detailed lesion characterization. Following this examination, the patient was diagnosed with mature cystic ovarian teratoma complicated by rupture. Surgery was performed, and the outcome was favorable. The cases of ruptured cystic teratomas are rare, and to our knowledge, this is the first occurrence described in literature. Special attention must be paid when confronting with such a case in medical practice, since it can easily misdiagnosed as peritoneal carcinomatosis.

Background Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme β-glucocerebrosidase (GCase), are the most frequent genetic risk factor for Parkinson’s disease (PD). GBA-related PD (GBA-PD) patients have higher risk of dementia and reduced survival than non-carriers. Preclinical studies and one open-label trial in humans demonstrated that the chaperone ambroxol (ABX) increases GCase levels and modulates α-synuclein levels in the blood and cerebrospinal fluid (CSF).Methods and analysis In this multicentre, double-blind, placebo-controlled, phase II clinical trial, we randomise patients with GBA-PD in a 1:1 ratio to either oral ABX 1.2 g/day or placebo. The duration of treatment is 52 weeks. Each participant is assessed at baseline and weeks 12, 26, 38, 52 and 78. Changes in the Montreal Cognitive Assessment score and the frequency of mild cognitive impairment and dementia between baseline and weeks 52 are the primary outcome measures. Secondary outcome measures include changes in validated scales/questionnaires assessing motor and non-motor symptoms. Neuroimaging features and CSF neurodegeneration markers are used as surrogate markers of disease progression. GCase activity, ABX and α-synuclein levels are also analysed in blood and CSF. A repeated-measures analysis of variance will be used for elaborating results. The primary analysis will be by intention to treat.Ethics and dissemination The study and protocols have been approved by the ethics committee of centres. The study is conducted according to good clinical practice and the Declaration of Helsinki. The trial findings will be published in peer-reviewed journals and presented at conferences.Trial registration numbers NCT05287503, EudraCT 2021-004565-13.

Abstract Background The syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid (CSF) Lymphocytosis (HaNDL) is classified among secondary headaches attributed to “non-infectious, inflammatory intracranial disease”. Despite its classification among secondary headaches, the current definition of HaNDL does not contemplate a causal agent. Thus, the aetiology, as well as the pathogenesis of both the headache and the transient focal deficits, remains unknown. Case presentation We describe a 29-year-old healthy male developing episodes of thunderclap headaches associated with recurrence of hemiparesis/hemi-paraesthesia; CSF showed lymphocytosis 200/mm3 and increased albumin; brain MRI revealed widespread leptomeningeal enhancement and a non-enhancing, circular diffusion restriction in the splenium of corpus callosum. Screening for neurotropic pathogens detected Epstein-Barr (EBV) DNA in serum and CSF, interpreted as a primary EBV infection once the seroconversion of EBV nuclear antigen (EBNA) IgM to IgG was proven on follow-up. Transcranial Doppler detected, during headache, increased flow velocity in middle cerebral arteries, possibly indicating vasospasm. Oral nimodipine was administered, with prompt clinical recovery, resolution of CSF/MRI abnormalities, and normalization of flow velocities in middle cerebral arteries. Case-based review Although the definition of HaNDL does not contemplate a viral trigger or abnormal brain imaging, we found other literature cases of HaNDL associated with direct or indirect signs of CNS infection. Conclusions At least in a proportion of patients, a viral aetiology may have a role in HaNDL. Whatever the aetiology, we suggest that the pathogenic mechanism may rely on the (viral or other) agent ultimately triggering cerebral vasoconstriction, which would explain both focal symptoms and headache. Calcium channel blockers might be a therapeutic option.

Diabetic foot is a severe complication of diabetes that occurs as a result of poor glycemic control, being associated with significant morbidity and mortality. Mortality associated with this disease is estimated at 5% in the first 12 months, and about 42% in the next 5 years. On average, it affects about 15% of people with diabetes during their lifetime, including as possible manifestations neuropathy, peripheral vascular disease, and subsequent ulceration which, if treated incorrectly, can lead to amputation. This paper presents a retrospective and descriptive study of patients diagnosed and treated for diabetic foot ulcers in the Proctoven Clinic. The study includes a group of 50 cases diagnosed with diabetic foot over a period of 5 years, from 01.01.2017 to 31.12.2021. In this study, the effectiveness of the modern treatment methods most frequently used in the surgical treatment of the diabetic foot is analyzed based on several parameters.

Gastric duplication cysts (GDCs) in adults are exceedingly rare, with only a few documented cases in medical literature. The spectrum of clinical presentations varies widely, ranging from asymptomatic to severe symptoms such as hematemesis, vomiting or abdominal pain. Among the less common complications associated with GDCs, segmental portal hypertension is a notable rarity. We present a compelling case report of a patient exhibiting signs of segmental portal hypertension, where ultrasound and echo-endoscopy revealed a sizable gastric duplication cyst as the underlying etiology. Recognizing the scarcity of literature on GDCs in adult patients, we conducted a thorough review to underscore the diagnostic significance of ultrasonography and endoscopic ultrasound (EUS) in accurately identifying these congenital anomalies. This case report and comprehensive literature review emphasize the pivotal role of EUS and abdominal ultrasound in achieving an accurate diagnosis of GDCs. By shedding light on the diagnostic and therapeutic intricacies, we aim to raise awareness among clinicians regarding this rare pathology and the importance of multimodal imaging approaches for optimal patient management.

This study aimed to evaluate the effects of different starch sources on the extrusion process, kibble characteristics and diet palatability for dogs. Seven diets with corn, brown rice, sorghum, potato starch, sweet potato flour, chickpea and pea as the only starch source were evaluated. The dietary inclusion of the starch sources varied between 330.13 and 643.84 g/kg to provide similar starch concentrations in all diets (around 300 g/kg). The conditioning temperature and the volume of water added to the preconditioner during the processing of the diets were measured, and the extruder variables evaluated were knife speed, feed rate, screw speed, amperage and productivity. For the physical characteristics of kibbles, density, size, expansion index and hardness were measured. Porosity variables evaluated were total pore area, average pore area and number of pores. Diet palatability was evaluated in 16 dogs. Six paired palatability tests were performed, in which all diets were compared to the corn diet, with two consecutive days per test, totalling 32 repetitions (16 dogs × 2 days/test). Diets with tubers presented lower kibble density and higher size, expansion index and hardness than the diets with cereals and pulses (p < 0.001). Diets with tubers had more pores than pulses (p < 0.001). The inclusion of pea results in kibbles that were less expanded and with fewer pores (p < 0.001). Dogs preferred all diets compared with the corn-based diet (p < 0.001), except for the sweet potato diet. The dietary inclusion of tubers as starch sources results in higher kibble expansion, size, hardness, porosity and lower density. The inclusion of pea results in kibbles that are less expanded and with a lower number of pores. The diet's moisture content and texture affect diet palatability in dogs. HIGHLIGHTS: Tubers, such as potato, as starch sources result in higher kibble expansion, size, hardness and porosity. Starch sources with a high fibre concentration, such as pea and chickpea, result in diets with kibbles less expanded and with less porosity. The moisture content and physical characteristics of kibbles affect the diet palatability in dogs. [ABSTRACT FROM AUTHOR]

Monitoring of hormone replacement therapy represents a major challenge in the management of congenital adrenal hyperplasia (CAH). In the absence of clear guidance and standardised monitoring strategies, there is no consensus among clinicians regarding the relevance of various biochemical markers used in practice, leading to wide variability in their application and interpretation. In this review, we summarise the published evidence on biochemical monitoring of CAH. We discuss temporal variations of the most commonly measured biomarkers throughout the day, the interrelationship between different biomarkers, as well as their relationship with different glucocorticoid and mineralocorticoid treatment regimens and clinical outcomes. Our review highlights significant heterogeneity across studies in both aims and methodology. However, we identified key messages for the management of patients with CAH. The approach to hormone replacement therapy should be individualised, based on the individual hormonal profile throughout the day in relation to medication. There are limitations to using 17‐hydroxyprogesterone, androstenedione and testosterone, and the role of additional biomarkers such 11‐oxygenated androgens which are more disease specific should be further established. Noninvasive monitoring via salivary and urinary steroid measurements is becoming increasingly available and should be considered, especially in the management of children with CAH. Additionally, this review indicates the need for large scale longitudinal studies analysing the interrelation between different monitoring strategies used in clinical practice and health outcomes in children and adults with CAH. [ABSTRACT FROM AUTHOR]

The correction notice in the Future Internet journal addresses mistakes in figures published in the original article by Vasilas et al. The corrected figures include updates to Figure 6, addition of Figure 7 and Figure 10, and updates to Figures A4 and A5. The reordering of original figures is also detailed in the notice. The authors confirm that the scientific conclusions remain unaffected by these corrections. [Extracted from the article]

The study of the genetic markers and identifying new markers involves an increasing number of research projects in the fields of genetics of immunology, biochemical genetics, molecular genetics, quantity genetics and the genetic improvement of animals. Some studies on genes frequency determining the red cells specificity and for whey hemoglobin are approached in the present report. In this way, some blood factors, most of them belonging to B system (the most complex system in cattle) have been evidenced. The lowest gene frequency was present in K factor (7%), and highest one in, O1, G’ , W and F1 (100%). In addition to basic importance on knowledge and determination of cattle population genetic structure for studied protein loci, another theme proposed to correlate hemoglobin type with some traits of economical importance: milk yield, fat and protein content, fat and protein yield. Higher performance was recorded by HbA/HbA individuals.

Introduction During the Corona virus pandemic, anxiety was one of the most felt emotions. Anxiety can lead to maladaptive coping behaviors, including decreased productivity at work. There are some mechanisms that buffer the devastaing effect that anxiety can have, and one of them is self-compassion. The impact on mental health during the pandemic has increased, especially among healthcare professionals, and needs further exploration Objectives This study aims to investigate the relationships between anxiety, productivity and self-compassion at work among healthcare professionals, as well as, the possibility of self-compassion playing the role of a relationship’s moderator, in a pandemic context. Methods The study gathers the result from 202 participants, who completed a questionnaire on an online platform. We examined the link between anxiety, respectively COVID-19 anxiety, productivity and self-compassion, as well as the link between self-compassion and productivity among healthcare workers in a pandemic context. In order to emphasize the objectives, the validated BAI, CAS, SPS-SV and SCS-SV scales were used. Results In terms of results, significant negative correlations were identified in the relationships between anxiety, COVID-19 anxiety, productivity and self-compassion, and a significantly positive correlation in the self-compassion-productivity relationship. Also, we studied if self-compassion could be a relationship moderator. As the results show, the study identified a statistically insignificant effect of self-compassion on the relationships anxiety-productivity and anxiety of COVID-19-productivity, among health workers. Conclusions The present study has achieved its proposed objectives, so that through future research, anxiety, productivity and self-compassion can be explored not only in a pandemic context, but also in a normal context of professional activity in the medical field, and it can also contribute to the identification of other moderators of the anxiety-productivity relationship. Disclosure of Interest None Declared

Dentre outras coisas, nesta entrevista John Dugard versa sobre a tipificação de apartheid e seus vínculos com o colonialismo, a legalidade dos movimentos palestinos de resistência, a atuação dos diferentes relatores especiais designados pelo CDH-ONU e compara o caso sul-africano e israelense, assim como sua interpretação do apartheid israelense (restrita aos TPO) com aquela contida na bibliografia e em outros relatórios, atinente ao território como um todo. Ainda, comenta sobre suas expectativas quanto ao processo movido contra o Estado de Israel pelo Estado da Palestina no Tribunal Penal Internacional que, em 2021, reconheceu ter jurisdição sobre o caso.

This paper aims the identification of the Organization Designation Authorization (ODA) regulatory approaches adopted by the United States, using the Boeing 737 MAX 8 certification process as a basis, by revising the ODA’s certification role and what can be enhanced on the ODA program, considering the data from the Federal Aviation Administration (FAA), the U.S. Department of Transportation, AND the Office of Inspector General (OIG), and comparing them to the regulatory basis in Europe and in Brazil. An assessment of undue pressure on ODA Unit members and other aspects, such as conflicting restraints, analysing their consequences and roles for the process’ safety, is presented, as well as a comparison with the independent design assurance system adopted by the other two agencies. Therefore, the discussion around the ODA’s aircraft certification processes highlights the ODA model drawbacks, and what can be learned from other models to improve it, so the industry and the society can fully benefit from this system.

This review explores the potential benefits of fecal microbiota transplantation (FMT) as an adjunct treatment in tuberculosis (TB), drawing parallels from its efficacy in inflammatory bowel disease (IBD). FMT has shown promise in restoring the gut microbial balance and modulating immune responses in IBD patients. Considering the similarities in immunomodulation and dysbiosis between IBD and TB, this review hypothesizes that FMT may offer therapeutic benefits as an adjunct therapy in TB. Methods: We conducted a systematic review of the existing literature on FMT in IBD and TB, highlighting the mechanisms and potential implications of FMT in the therapeutic management of both conditions. The findings contribute to understanding FMT’s potential role in TB treatment and underscore the necessity for future research in this direction to fully leverage its clinical applications. Conclusion: The integration of FMT into the comprehensive management of TB could potentially enhance treatment outcomes, reduce drug resistance, and mitigate the side effects of conventional therapies. Future research endeavors should focus on well-designed clinical trials to develop guidelines concerning the safety and short- and long-term benefits of FMT in TB patients, as well as to assess potential risks.

Feed additives, such as prebiotics and essential oils, are used in pet foods and can affect digestibility, palatability, and intestinal functionality of dogs. The combined effects of yeast cell wall and oregano essential oil on apparent total tract digestibility (ATTD) and palatability of diet, intestinal fermentation products, and fecal microbiota in dogs were analyzed. Eighteen adult dogs were fed for 20 days with three dry extruded diets for adult dogs: control (without the additive), a diet containing 1.5 kg/ton of yeast cell wall and oregano essential oil (1.5YCO), and a diet containing 3.0 kg/ton of yeast cell wall and oregano essential oil (3.0YCO). The inclusion of both levels of YCO reduced the intake ratio. The addition of 3.0YCO reduced the ATTD of dry matter, compared to the control group (p < 0.05). There were greater putrescine and cadaverine concentrations and lower histamine and ammonia (p < 0.05) in the feces of dogs fed 3.0YCO. In addition, fecal odor of dogs fed YCO was less fetid than the control group (p < 0.05). There was greater fecal bacterial diversity in dogs fed with both dietary concentrations of YCO evaluated (p < 0.05). Dogs fed 1.5YCO and 3.0YCO showed higher relative abundance of Blautia and Faecalibacterium and lower abundance of Streptococcus (p < 0.05) in the feces, in comparison to the control group. Given the modulation of microorganisms considered beneficial and the lower fecal concentrations of histamine, phenols, and ammonia, the YCO blend resulted in indicators of improvement of intestinal functionality in dogs.

At present, it is necessary to identify specific biochemical, molecular, and genetic markers that can reliably aid in screening digestive cancer and correlate with the degree of disease development. Has-miR-129-5p is a small, non-coding molecule of RNA, circulating in plasma, gastric juice, and other biological fluids; it plays a protective role in tumoral growth, metastasis, etc. Furthermore, it is involved in various diseases, from the development of digestive cancer in cases of downregulation to neurodegenerative diseases and depression. Methods: We examined meta-analyses, research, and studies related to miR-129-5-p involved in digestive cancer and its implications in cancer processes, as well as metastasis, and described its implications in neurological diseases. Conclusions: Our review outlines that miR-129-5p is a significant controller of different pathways, genes, and proteins and influences different diseases. Some important pathways include the WNT and PI3K/AKT/mTOR pathways; their dysregulation results in digestive neoplasia and neurodegenerative diseases.

In a mutually beneficial connection with its host, the gut microbiota affects the host’s nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.

As the complexity and integration of electronic devices increase, understanding and mitigating side-channel vulnerabilities will remain a critical area of cybersecurity research. The new and intriguing software-based thermal side-channel attacks and countermeasures use thermal emissions from a device to extract or defend sensitive information, by reading information from the built-in thermal sensors via software. This work extends the Hot-n-Cold anomaly detection technique, applying it in circumstances much closer to the real-world computational environments by detecting irregularities in the Linux command behavior through CPU temperature monitoring. The novelty of this approach lies in the introduction of five types of noise across the CPU, including moving files, performing extended math computations, playing songs, and browsing the web while the attack detector is running. We employed Hot-n-Cold to monitor core temperatures on three types of CPUs utilizing two commonly used Linux terminal commands, ls and chmod. The results show a high correlation, approaching 0.96, between the original Linux command and a crafted command, augmented with vulnerable system calls. Additionally, a Machine Learning algorithm was used to classify whether a thermal trace is augmented or not, with an accuracy of up to 88%. This research demonstrates the potential for detecting attacks through thermal sensors even when there are different types of noise in the CPU, simulating a real-world scenario. [ABSTRACT FROM AUTHOR]

Gastric cancer stands as the fourth leading cause of cancer-related deaths globally, primarily comprising adenocarcinomas, categorized by anatomic location and histologic type. Often diagnosed at advanced stages, gastric cancer prognosis remains poor. To address the critical need for accurate tumoral markers for gastric cancer diagnosis, we conducted a study to assess classical markers like CEA and CA-19-9 alongside the novel marker miR-106. Our investigation revealed distinct dynamics of these markers compared to non-cancerous groups, although no disparities were observed across different disease stages. Univariable and multivariable logistic regression analyses demonstrated that elevated levels of miR-106, CEA and CA 19-9 were predictive of a positive histopathological exam, with the respective odds ratios of 12.032 (95% CI: 1.948–74.305), 30 (95% CI: 3.141–286.576), and 55.866 (95% CI: 4.512–691.687). Subsequently, we utilized predicted probabilities from regression models to construct receiver operating characteristic (ROC) curves, identifying CA 19-9 as the optimal predictor for gastric adenocarcinoma diagnosis when considering age and gender, with an area under the curve (AUC) of 0.936 (p < 0.001). Hence, classical markers exhibit superior performance compared to the novel marker miR-106 in predicting gastric adenocarcinoma. [ABSTRACT FROM AUTHOR]