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1. Corrigendum to 'European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)' (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))

Author

Egea, J. Fabregat, I. Frapart, Y.M. Ghezzi, P. Görlach, A. Kietzmann, T. Kubaichuk, K. Knaus, U.G. Lopez, M.G. Olaso-Gonzalez, G. Petry, A. Schulz, R. Vina, J. Winyard, P. Abbas, K. Ademowo, O.S. Afonso, C.B. Andreadou, I. Antelmann, H. Antunes, F. Aslan, M. Bachschmid, M.M. Barbosa, R.M. Belousov, V. Berndt, C. Bernlohr, D. Bertrán, E. Bindoli, A. Bottari, S.P. Brito, P.M. Carrara, G. Casas, A.I. Chatzi, A. Chondrogianni, N. Conrad, M. Cooke, M.S. Costa, J.G. Cuadrado, A. My-Chan Dang, P. De Smet, B. Debelec-Butuner, B. Dias, I.H.K. Dunn, J.D. Edson, A.J. El Assar, M. El-Benna, J. Ferdinandy, P. Fernandes, A.S. Fladmark, K.E. Förstermann, U. Giniatullin, R. Giricz, Z. Görbe, A. Griffiths, H. Hampl, V. Hanf, A. Herget, J. Hernansanz-Agustín, P. Hillion, M. Huang, J. Ilikay, S. Jansen-Dürr, P. Jaquet, V. Joles, J.A. Kalyanaraman, B. Kaminskyy, D. Karbaschi, M. Kleanthous, M. Klotz, L.O. Korac, B. Korkmaz, K.S. Koziel, R. Kračun, D. Krause, K.H. Křen, V. Krieg, T. Laranjinha, J. Lazou, A. Li, H. Martínez-Ruiz, A. Matsui, R. McBean, G.J. Meredith, S.P. Messens, J. Miguel, V. Mikhed, Y. Milisav, I. Milković, L. Miranda-Vizuete, A. Mojović, M. Monsalve, M. Mouthuy, P.A. Mulvey, J. Münzel, T. Muzykantov, V. Nguyen, I.T.N. Oelze, M. Oliveira, N.G. Palmeira, C.M. Papaevgeniou, N. Pavićević, A. Pedre, B. Peyrot, F. Phylactides, M. Pircalabioru, G.G. Pitt, A.R. Poulsen, H.E. Prieto, I. Rigobello, M.P. Robledinos-Antón, N. Rodríguez-Mañas, L. Rolo, A.P. Rousset, F. Ruskovska, T. Saraiva, N. Sasson, S. Schröder, K. Semen, K. Seredenina, T. Shakirzyanova, A. Smith, G.L. Soldati, T. Sousa, B.C. Spickett, C.M. Stancic, A. Stasia, M.J. Steinbrenner, H. Stepanić, V. Steven, S. Tokatlidis, K. Tuncay, E. Turan, B. Ursini, F. Vacek, J. Vajnerova, O. Valentová, K. Van Breusegem, F. Varisli, L. Veal, E.A. Yalçın, A.S. Yelisyeyeva, O. Žarković, N. Zatloukalová, M. Zielonka, J. Touyz, R.M. Papapetropoulos, A. Grune, T. Lamas, S. Schmidt, H.H.H.W. Di Lisa, F. Daiber, A.

Abstract

The authors regret that they have to correct the acknowledgement of the above mentioned publication as follows: This article/publication is based upon work from COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. For further information see www.cost.eu. The authors would like to apologise for any inconvenience caused. © 2017 The Author(s)

Published
2018

2. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017)

Author

Egea, J., Fabregat, I., Frapart, Y.M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U.G., Lopez, M.G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O.S., Afonso, C.B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M.M., Barbosa, R.M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S.P., Brito, P.M., Carrara, G., Casas, A.I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M.S., Costa, J.G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-Butuner, B., Dias, I.H.K., Dunn, J.D., Edson, A.J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A.S., Fladmark, K.E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J.A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L.O., Korac, B., Korkmaz, K.S., Koziel, R., Kračun, D., Krause, K.H., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., McBean, G.J., Meredith, S.P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P.A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I.T.N., Oelze, M., Oliveira, N.G., Palmeira, C.M., and Papaevgeniou, N.

Published
2018

3. Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162]

Author

Egea, J., primary, Fabregat, I., additional, Frapart, Y.M., additional, Ghezzi, P., additional, Görlach, A., additional, Kietzmann, T., additional, Kubaichuk, K., additional, Knaus, U.G., additional, Lopez, M.G., additional, Olaso-Gonzalez, G., additional, Petry, A., additional, Schulz, R., additional, Vina, J., additional, Winyard, P., additional, Abbas, K., additional, Ademowo, O.S., additional, Afonso, C.B., additional, Andreadou, I., additional, Antelmann, H., additional, Antunes, F., additional, Aslan, M., additional, Bachschmid, M.M., additional, Barbosa, R.M., additional, Belousov, V., additional, Berndt, C., additional, Bernlohr, D., additional, Bertrán, E., additional, Bindoli, A., additional, Bottari, S.P., additional, Brito, P.M., additional, Carrara, G., additional, Casas, A.I., additional, Chatzi, A., additional, Chondrogianni, N., additional, Conrad, M., additional, Cooke, M.S., additional, Costa, J.G., additional, Cuadrado, A., additional, My-Chan Dang, P., additional, De Smet, B., additional, Debelec-Butuner, B., additional, Dias, I.H.K., additional, Dunn, J.D., additional, Edson, A.J., additional, El Assar, M., additional, El-Benna, J., additional, Ferdinandy, P., additional, Fernandes, A.S., additional, Fladmark, K.E., additional, Förstermann, U., additional, Giniatullin, R., additional, Giricz, Z., additional, Görbe, A., additional, Griffiths, H., additional, Hampl, V., additional, Hanf, A., additional, Herget, J., additional, Hernansanz-Agustín, P., additional, Hillion, M., additional, Huang, J., additional, Ilikay, S., additional, Jansen-Dürr, P., additional, Jaquet, V., additional, Joles, J.A., additional, Kalyanaraman, B., additional, Kaminskyy, D., additional, Karbaschi, M., additional, Kleanthous, M., additional, Klotz, L.O., additional, Korac, B., additional, Korkmaz, K.S., additional, Koziel, R., additional, Kračun, D., additional, Krause, K.H., additional, Křen, V., additional, Krieg, T., additional, Laranjinha, J., additional, Lazou, A., additional, Li, H., additional, Martínez-Ruiz, A., additional, Matsui, R., additional, McBean, G.J., additional, Meredith, S.P., additional, Messens, J., additional, Miguel, V., additional, Mikhed, Y., additional, Milisav, I., additional, Milković, L., additional, Miranda-Vizuete, A., additional, Mojović, M., additional, Monsalve, M., additional, Mouthuy, P.A., additional, Mulvey, J., additional, Münzel, T., additional, Muzykantov, V., additional, Nguyen, I.T.N., additional, Oelze, M., additional, Oliveira, N.G., additional, Palmeira, C.M., additional, Papaevgeniou, N., additional, Pavićević, A., additional, Pedre, B., additional, Peyrot, F., additional, Phylactides, M., additional, Pircalabioru, G.G., additional, Pitt, A.R., additional, Poulsen, H.E., additional, Prieto, I., additional, Rigobello, M.P., additional, Robledinos-Antón, N., additional, Rodríguez-Mañas, L., additional, Rolo, A.P., additional, Rousset, F., additional, Ruskovska, T., additional, Saraiva, N., additional, Sasson, S., additional, Schröder, K., additional, Semen, K., additional, Seredenina, T., additional, Shakirzyanova, A., additional, Smith, G.L., additional, Soldati, T., additional, Sousa, B.C., additional, Spickett, C.M., additional, Stancic, A., additional, Stasia, M.J., additional, Steinbrenner, H., additional, Stepanić, V., additional, Steven, S., additional, Tokatlidis, K., additional, Tuncay, E., additional, Turan, B., additional, Ursini, F., additional, Vacek, J., additional, Vajnerova, O., additional, Valentová, K., additional, Van Breusegem, F., additional, Varisli, L., additional, Veal, E.A., additional, Yalçın, A.S., additional, Yelisyeyeva, O., additional, Žarković, N., additional, Zatloukalová, M., additional, Zielonka, J., additional, Touyz, R.M., additional, Papapetropoulos, A., additional, Grune, T., additional, Lamas, S., additional, Schmidt, H.H.H.W., additional, Di Lisa, F., additional, and Daiber, A., additional

Published
2018
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4. Selective inhibition of prostacyclin synthase activity by rofecoxib

Author

Enzo Spisni, Antonio Strillacci, Cristiana Griffoni, Mattia Toni, Markus Bachschmid, Vittorio Tomasi, Griffoni C., Spisni E., Strillacci A., Toni M., Bachschmid M.M., and V. Tomasi

Subjects
CYCLOXYGENASE-2 INHIBITORS, Umbilical Veins, Time Factors, Endothelium, endothelium, cyclooxygenase-2 inhibitors, Prostacyclin, Enzyme-Linked Immunosorbent Assay, Pharmacology, rofecoxib, Umbilical vein, Prostacyclin synthase, Lactones, Cytochrome P-450 Enzyme System, Microsomes, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, nonsteroidal anti-inflammatory agents, prostacyclin synthase, Sulfones, Rofecoxib, Aorta, Cells, Cultured, biology, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Endothelial Cells, Cell Biology, Articles, Epoprostenol, Enzyme assay, Intramolecular Oxidoreductases, medicine.anatomical_structure, biology.protein, Celecoxib, Molecular Medicine, Cattle, Endothelium, Vascular, NONSTEROIDAL ANTI-INFLAMATORY AGENTS, medicine.drug
Abstract

The development of cyclooxygenase-2 (COX-2) selective inhibitors prompted studies aimed at treating chronic inflammatory diseases and cancer by using this new generation of drugs.Yet, several recent reports pointed out that long-term treatment of patients with COX-2 selective inhibitors (especially rofecoxib) caused severe cardiovascular complicances. The aim of this study was to ascertain whether, in addition to inhibiting COX-2, rofecoxib may also affect prostacyclin (PGI2) level by inhibiting PGI2 forming enzyme (prostacyclin synthase, PGIS). In order to evaluate if selective (celecoxib, rofecoxib) and non-selective (aspirin, naproxen) anti-inflammatory compounds could decrease PGI2 production in endothelial cells by inhibiting PGIS, we analyzed the effect of anti-inflammatory compounds on the enzyme activity by ELISA assay after addition of exogenous substrate, on PGIS protein levels by Western blotting and on its subcellular distribution by confocal microscopy. We also analyzed the effect of rofecoxib on PGIS activity in bovine aortic microsomal fractions enriched in PGIS. This study demonstrates an inhibitory effect of rofecoxib on PGIS activity in human umbilical vein endothelial (HUVE) cells and in PGIS-enriched bovine aortic microsomal fractions, which is not observed by using other anti-inflammatory compounds. The inhibitory effect of rofecoxib is associated neither to a decrease of PGIS protein levels nor to an impairment of the enzyme intracellular localization. The results of this study may explain the absence of a clear relationship between COX-2 selectivity and cardiovascular side effects. Moreover, in the light of these results we propose that novel selective COX-2 inhibitors should be tested on PGI2 synthase activity inhibition.

Published
2007

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