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1. Dupilumab Reduces Asthma Disease Burden and Recurrent SCS Use in Patients with CRSwNP and Coexisting Asthma

Author

Gurnell M, Radwan A, Bachert C, Lugogo N, Cho SH, Nash S, Zhang H, Khan AH, Jacob-Nara JA, Rowe PJ, and Deniz Y

Subjects
asthma control, asthma exacerbation, chronic rhinosinusitis with nasal polyps, systemic corticosteroids, liberty sinus-24, liberty sinus-52, Immunologic diseases. Allergy, RC581-607
Abstract

Mark Gurnell,1,2 Amr Radwan,3 Claus Bachert,4– 6 Njira Lugogo,7 Seong H Cho,8 Scott Nash,9 Haixin Zhang,9 Asif H Khan,10 Juby A Jacob-Nara,11 Paul J Rowe,11 Yamo Deniz9 1Department of Medicine, Wellcome–MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK; 2NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK; 3Global Medical Affairs, Regeneron Pharmaceuticals Inc., Uxbridge, UK; 4Department of Otorhinolaryngology – Head and Neck Surgery, University Hospital of Münster, Münster, Germany; 5International Airway Research Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 6Division of ENT Diseases, CLINTEC, Karolinska Hospital, Stockholm University, Stockholm, Sweden; 7Division of Pulmonary & Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA; 8Division of Allergy-Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA; 9Medical Affairs, Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA; 10Global Medical Affairs, Sanofi, Chilly-Mazarin, France; 11Global Medical Affairs, Sanofi, Bridgewater, NJ, USACorrespondence: Mark Gurnell, Metabolic Research Laboratories, Wellcome–MRC Institute of Metabolic Science, Level 4, Box 289, Addenbrooke’s Hospital, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK, Tel +44 1223 336792, Email mg299@medschl.cam.ac.ukPurpose: Dupilumab significantly reduced the requirement for systemic corticosteroids (SCS) in patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP). Patients with CRSwNP and coexisting asthma typically have a higher disease burden and have more difficulty in managing disease. Here, we report an analysis of asthma outcomes and SCS use in patients with CRSwNP and coexisting asthma.Patients and Methods: This was a post hoc analysis of the randomized, placebo-controlled SINUS-24 and SINUS-52 studies (NCT02912468/NCT02898454) in patients with severe CRSwNP and coexisting asthma (patient self-reported) from the pooled intention-to-treat population randomized to dupilumab 300 mg every 2 weeks or placebo. On-treatment SCS use was estimated using Kaplan–Meier analysis. Forced expiratory volume in 1 s (FEV1), percent predicted FEV1, and the 6-item Asthma Control Questionnaire (ACQ-6) were assessed at baseline and Week 24 (pooled SINUS-24/52) in patients with/without history of asthma exacerbation or prior SCS use.Results: Of 337 patients with coexisting asthma, 88 (26%) required on-treatment SCS use. The requirement for on-treatment SCS use for any reason was significantly lower with dupilumab (20/167 patients; 12%) vs placebo (68/170; 40%); hazard ratio (95% confidence interval) 0.248 (0.150– 0.409); p

Published
2024

2. Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SINUS-52 Studies

Author

Maspero JF, Bachert C, Martinez FJ, Hanania NA, Ortiz B, Patel N, Mannent LP, Praestgaard A, Pandit-Abid N, Siddiqui S, and Hardin M

Subjects
obstructive lung disease, chronic obstructive pulmonary disease, dupilumab, type 2 inflammation, interleukin-4, interleukin-13, Immunologic diseases. Allergy, RC581-607
Abstract

Jorge F Maspero,1 Claus Bachert,2,3 Fernando J Martinez,4 Nicola A Hanania,5 Benjamin Ortiz,6 Naimish Patel,7 Leda P Mannent,8 Amy Praestgaard,7 Nami Pandit-Abid,9 Shahid Siddiqui,6 Megan Hardin7 1Allergy and Respiratory Research Unit, Fundación CIDEA, Buenos Aires, Argentina; 2Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium; 3Division of ENT Diseases, CLINTEC, Karolinska Institutet, Stockholm, Sweden; 4Division of Pulmonary and Critical Care, Weill Cornell Medical College, New York, NY, USA; 5Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA; 6Immunology and Allergy Medical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 7Immunology and Inflammation, Sanofi, Cambridge, MA, USA; 8Global Clinical Development, Sanofi, Chilly-Mazarin, France; 9Immunology and Inflammation, Sanofi, Bridgewater, NJ, USACorrespondence: Jorge F Maspero, Allergy and Respiratory Research Unit, Fundación CIDEA, Paraguay 2035, Buenos Aires, C1121ABE, Argentina, Tel +54 91141837294, Email jorge.maspero@fundacioncidea.org.arPurpose: To provide a descriptive summary of clinical efficacy and health-related quality of life (HRQoL) measures in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and clinical features of obstructive lung disease in the Phase III dupilumab studies SINUS-24 and SINUS-52 (NCT02912468, NCT02898454).Patients and Methods: Patients met a “broad” definition of having clinical features of obstructive lung disease with any of 3 criteria: (i) pre-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < 0.70 and smoking history; (ii) patient-reported medical history of chronic obstructive pulmonary disease (COPD); or (iii) asthma with > 10 pack-years’ smoking history. A “narrow” definition including criteria (i) or (ii) was also analyzed. CRSwNP and HRQoL measures were evaluated in all patients and lung function (FEV1; FEV1/FVC ratio) was captured and analyzed only in those patients who had a self-reported history of asthma.Results: Across both studies, 131 patients met the “broad” definition, of whom 90 also had asthma, and 115 patients met the “narrow” definition, of whom 74 had asthma. CRSwNP outcomes and HRQoL were improved with dupilumab vs placebo in both the broad and narrow subgroups. Among the 90 patients who met the broad definition and had asthma, dupilumab improved pre-bronchodilator FEV1 and FEV1/FVC ratio at Week 16 (least squares mean differences vs placebo: 0.38 L [95% confidence interval: 0.17, 0.59; p = 0.0004] and 4.8% [1.7%, 7.9%; p = 0.0024], respectively) sustained through Week 24. Similar results were seen in the “narrow” subgroup with asthma.Conclusion: In a population of patients with CRSwNP and clinical features of obstructive lung disease, dupilumab improved CRSwNP and HRQoL outcomes, and, among those with a history of asthma, also improved lung function. These results support further analyses of dupilumab in patients with evidence of type 2 inflammation and obstructive lung disease such as COPD.Keywords: obstructive lung disease, chronic obstructive pulmonary disease, dupilumab, type 2 inflammation, interleukin-4, interleukin-13

Published
2023

5. Rapid and Continuing Improvements in Nasal Symptoms with Dupilumab in Patients with Severe CRSwNP

Author

Bachert C, Khan AH, Hopkins C, Blaiss MS, Soler ZM, Nash S, Siddiqui S, Praestgaard A, Deniz Y, Rowe PJ, and Jacob-Nara JA

Subjects
chronic rhinosinusitis with nasal polyps, dupilumab, nasal polyp score, nasal congestion, Immunologic diseases. Allergy, RC581-607
Abstract

Claus Bachert,1– 3 Asif H Khan,4 Claire Hopkins,5 Michael S Blaiss,6 Zachary M Soler,7 Scott Nash,8 Shahid Siddiqui,8 Amy Praestgaard,9 Yamo Deniz,8 Paul J Rowe,10 Juby A Jacob-Nara10 1Upper Airways Research Laboratory and Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2Division of ENT Diseases, CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3International Airway Research Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 4Global Medical Affairs, Sanofi, Chilly-Mazarin, France; 5Department of Otorhinolaryngology – Head and Neck Surgery, Guy’s and St Thomas’ Hospitals, London, UK; 6Department of Pediatrics, Medical College of Georgia at Augusta University, Augusta, GA, USA; 7Department of Otolaryngology – Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA; 8Medical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 9Department of Biostatistics, Sanofi, Cambridge, MA, USA; 10Global Medical Affairs, Sanofi, Bridgewater, NJ, USACorrespondence: Claus Bachert, Upper Airways Research Laboratory and Department of Otorhinolaryngology, Ghent University, Ghent, B-9000, Belgium, Tel +32 9332 5513, Email claus.bachert@ugent.bePurpose: In the phase 3 SINUS-24 (NCT02912468) and SINUS-52 (NCT02898454) studies in adults with severe chronic rhinosinusitis with nasal polyps (CRSwNP), dupilumab significantly improved the co-primary endpoints of change from baseline to Week 24 in nasal polyp score (NPS) and nasal congestion/obstruction (NC) vs placebo on background intranasal corticosteroids (standard of care [SOC]). This post hoc analysis of SINUS-24/-52 investigated the direction and magnitude of within-patient change in these endpoints over time.Methods: NPS (scale 0– 8) was assessed at Weeks 4, 8, 16, 24, 40, and 52 in SINUS-52 and Weeks 8, 16, and 24 in SINUS-24. Daily patient-reported NC scores (0 [no symptoms]– 3 [severe symptoms]) were averaged over 28 days. Within-patient changes from baseline were assessed through Week 24 in pooled SINUS-24/-52 (n = 438/286 dupilumab/SOC) and through Week 52 in SINUS-52 (n = 150/153).Results: In SINUS-52, NPS improved in 70.0% of dupilumab-treated patients at Week 4 vs 31.8% with SOC (odds ratio [OR] 5.2 [95% confidence interval 3.1– 8.8]) and 78.7% vs 28.2% at Week 52 (OR 10.6 [6.0– 18.7]) (all p < 0.0001). NC improved in 73.3% of dupilumab-treated patients at Week 4 vs 46.7% with SOC (OR 3.2 [2.0– 5.3]) and 86.9% vs 50.7% at Week 52 (OR 6.4 [3.5– 11.5]) (all p < 0.0001). Clinically meaningful (≥ 1 point) improvements in NPS occurred in 55.7% and 72.3% of dupilumab-treated patients at Weeks 4 and 52, respectively, vs 16.9% and 16.2% with SOC. Clinically meaningful (≥ 1 point) improvements in NC occurred in 16.7% and 67.6% of dupilumab-treated patients at Weeks 4 and 52, respectively, vs 3.9% and 20.8% with SOC. At Week 52, NPS worsening from baseline was observed in 5.7% of dupilumab-treated patients vs 40.1% with SOC and NC worsening in 2.1% vs 20.8%, respectively.Conclusion: Dupilumab provided rapid, continuing, and clinically relevant improvements over time in NPS and NC in most patients with severe CRSwNP in the SINUS studies.Graphical Abstract: Keywords: chronic rhinosinusitis with nasal polyps, dupilumab, nasal polyp score, nasal congestion

Published
2022

6. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2023
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8. Data Mining of Free-Text Responses: An Innovative Approach to Analyzing Patient Perspectives on Treatment for Chronic Rhinosinusitis with Nasal Polyps in a Phase IIa Proof-of-Concept Study for Dupilumab

Author

Khan AH, Abbe A, Falissard B, Carita P, Bachert C, Mullol J, Reaney M, Chao J, Mannent LP, Amin N, Mahajan P, Pirozzi G, and Eckert L

Subjects
crswnp, free-text data mining, patient perspective, self-assessment, sense of smell, Medicine (General), R5-920
Abstract

Asif H Khan,1 Adeline Abbe,1 Bruno Falissard,2 Paulo Carita,1 Claus Bachert,3,4 Joaquim Mullol,5 Matthew Reaney,6 Jingdong Chao,7 Leda P Mannent,1 Nikhil Amin,7 Puneet Mahajan,8 Gianluca Pirozzi,8 Laurent Eckert1 1Sanofi, Chilly-Mazarin, France; 2Centre de recherche en epidémiologie et santé des populations (CESP), INSERM U1018, Paris, France; 3Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 4CLINTEC, Karolinska Institutet, Stockholm, Sweden; 5Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Universitat de Barcelona; Clinical and Experimental Respiratory Immunoallergy, IDIBAPS; and CIBERES, Barcelona, Catalonia, Spain; 6IQVIA, Reading, UK; 7Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 8Sanofi, Bridgewater, NJ, USACorrespondence: Asif H KhanSanofi, 1 Avenue Pierre Brossolette, Chilly-Mazarin, 91380, FranceTel +33 1 60 49 77 77Email asif.khan@sanofi.comPurpose: Patient perspective is an important and increasingly sought-after complement to clinical assessment. The aim of this study was to transcribe individual patients’ experience of treatment in a dupilumab clinical trial through free-text responses with analysis using natural language processing (NLP) to obtain the unique perspective of patients on disease impact and unmet needs with existing treatment to inform future trial design.Patients and Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who were enrolled in a Phase IIa randomized controlled trial comparing dupilumab with placebo (NCT01920893) were invited to complete a self-assessment of treatment (SAT) tool at the end of treatment, asking, “What is your opinion on the treatment you had during the trial? What did you like or dislike about the treatment?” Free-text responses were analyzed for the overall cohort and according to treatment assignment using natural language processing including sentiment scoring. In a mixed-methods approach, quantitative patient-reported outcome (PRO) results were utilized to complement the qualitative analysis of free-text responses.Results: Of 60 patients enrolled in the study, 43 (71.6%) completed the SAT and responses from 37 patients were analyzed (placebo, n = 16; dupilumab, n = 21). Word analyses showed that the most common words were “smell,” “improve,” “staff,” “great,” “time,” and “good.” Across the whole cohort, “smell” was the most common symptom-related word. The words “smell” and “experience” were more likely to occur in patients treated with dupilumab. Patients treated with dupilumab also had more positive sentiment in their SAT responses than those who received placebo. The results from this qualitative analysis were reflected in quantitative PRO results.Conclusion: “Smell” was important to patients with CRSwNP, highlighting its importance as a patient-centric efficacy outcome measure in the context of clinical trials in CRSwNP.Trial Registration: ClinicalTrials.gov, NCT01920893. Registered 12 August 2013, https://www.clinicaltrials.gov/ct2/show/NCT01920893.Keywords: CRSwNP, free-text data mining, patient perspective, self-assessment, sense of smell

Published
2021

9. Association Between a Type 2 Inflammatory Disease Burden Score and Outcomes Among Patients with Asthma

Author

Price D, Menzies-Gow A, Bachert C, Canonica GW, Kocks J, Khan AH, Ye F, Rowe PJ, Lu Y, Kamat S, Carter V, and Voorham J

Subjects
type 2 inflammation, asthma, exacerbations, control, comorbidities, burden, Immunologic diseases. Allergy, RC581-607
Abstract

David Price,1,2 Andrew Menzies-Gow,3 Claus Bachert,4 Giorgio Walter Canonica,5 Janwillem Kocks,1 Asif H Khan,6 Fen Ye,7 Paul J Rowe,7 Yufang Lu,8 Siddhesh Kamat,8 Victoria Carter,1 Jaco Voorham1,9 1Observational and Pragmatic Research Institute (OPRI), Singapore; 2Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland; 3Royal Brompton Hospital, London, England; 4Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; 5Personalized Medicine Asthma and Allergy Center, Humanitas University and Research Hospital, IRCCS, Milan, Italy; 6Sanofi, Chilly-Mazarin, Paris, France; 7Sanofi, Bridgewater, NJ, USA; 8Regeneron Pharmaceuticals Inc., Westchester County, NY, USA; 9Data to Insights Research Solutions, Lisbon, PortugalCorrespondence: David PriceCentre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, ScotlandTel +65 6802 9724Email dprice@opri.sgBackground: Although prevalence of co-existing type 2 inflammatory diseases (cT2) in asthma patients has been reported, limited data exist regarding their impact on asthma outcomes.Objective: To assess the impact of cT2 burden on asthma outcomes and to evaluate patterns of clustering of cT2 in a real-world setting.Methods: From medical records of 4.5 million enrollees in 650 primary care practices in the UK (January 2010–December 2017), patients with ≥ 1 diagnosis code for asthma at any time pre-index date (date of most recent asthma-related medical encounter) and ≥ 2 asthma-related prescriptions during the year before index date were categorized into the Global Initiative of Asthma (GINA) guideline severity steps. A cT2 burden score (range 0– 9) was assigned based on the total number of co-existing conditions (allergic conjunctivitis, allergic rhinitis, anaphylaxis, eczema/atopic dermatitis, chronic rhinosinusitis, eosinophilic esophagitis, food allergy, nasal polyps, or urticaria) for which patients received a medical diagnosis. Multivariate regression models evaluated associations between cT2 burden score and asthma exacerbations and asthma control. Factor analysis was performed to assess which cT2 comorbidities were correlated and exhibited patterns of clustering.Results: Overall, 245,893 patients with asthma were included (mean [SD] age 44.8 [22.1] years; 43.8% male). Between 55% (GINA step 1) and 60% (GINA step 5) of asthma patients had a medical diagnosis for ≥ 1 other type2dx. Patients with increased cT2 burden were significantly more likely to experience asthma exacerbations and less likely to achieve asthma control.Conclusion: Asthma patients with a higher cumulative cT2 burden score were more likely to experience worse asthma outcomes than those without any cT2 (burden score of 0).Keywords: type 2 inflammation, asthma, exacerbations, control, comorbidities, burden

Published
2021

12. Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps

Author

Bachert C, Bhattacharyya N, Desrosiers M, and Khan AH

Subjects
disease severity, healthcare economics, paranasal sinus disease, quality of life, Immunologic diseases. Allergy, RC581-607
Abstract

Claus Bachert,1,2 Neil Bhattacharyya,3 Martin Desrosiers,4 Asif H Khan1,5 1Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; 4Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada; 5Sanofi, Chilly-Mazarin, FranceCorrespondence: Claus BachertUpper Airways Research Laboratory, Ghent University, C. Heymanslaan 10, Ghent, B-9000, BelgiumTel +32 9 332 6880Email Claus.Bachert@UGent.beAbstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology.Keywords: disease severity, healthcare economics, paranasal sinus disease, quality of life

Published
2021

13. Evaluation of in vitro Penetration of Fluticasone Propionate from MP-AzeFlu and Fluticasone Propionate Nasal Spray Through EpiAirway™606 Tissues Using Vertical Diffusion Cells

Author

Berger WE, Bachert C, Allara R, Koltun A, Kopietz F, Maus JG, and D'Addio AD

Subjects
absorption, allergic rhinitis, azelastine hydrochloride, mucosal penetration, pharmacology, Immunologic diseases. Allergy, RC581-607
Abstract

William E Berger,1 Claus Bachert,2 Robert Allara,3 Arkady Koltun,4 Ferdinand Kopietz,5 Joachim G Maus,5 Alexander D D’Addio3 1Allergy and Asthma Associates of Southern California, Mission Viejo, CA, USA; 2Ghent University Hospital, Ghent, Belgium; 3Meda Pharmaceuticals, Somerset, NJ, USA; 4Mylan Inc., Canonsburg, PA, USA; 5Meda Pharma GmbH & Co. KG (a Mylan Company), Bad Homburg, GermanyCorrespondence: William E BergerAllergy and Asthma Associates of Southern California, 27800 Medical Center Road #244, Mission Viejo, CA, USATel + 949-364-2900Fax + 949-365-0117Email weberger@uci.eduPurpose: Most patients with allergic rhinitis (AR) have moderate-to-severe disease, requiring complete and prompt relief when symptoms occur. The time course of fluticasone propionate (FP) penetration into nasal tissues after intranasal administration is not well characterized. The goal of this proof-of-concept study was to evaluate the mucosal penetration of FP from fixed-combination FP-azelastine nasal spray (MP-AzeFlu) compared with an FP-only nasal spray in an in vitro, 3-dimensional human bronchial tissue model.Materials and Methods: Absorption of FP from MP-AzeFlu and FP nasal spray was modeled using EpiAirway™ 606 (MatTek Corporation; Ashland, MA, USA) tissue cultured in vertical diffusion cells. The dosing amount of MP-AzeFlu was optimized in a pilot study. Based on the results of the pilot study, 10 μL of MP-AzeFlu (3.65 μg; n = 8) and 10 μL of FP nasal spray (5.00 μg; n = 8) were evaluated for penetration of tissue. Tissue integrity was monitored with Lucifer yellow. FP in the receiving media was quantified for each sample using liquid chromatography with tandem mass spectrometry.Results: MP-AzeFlu and FP nasal spray were associated with similar FP accumulation profiles in the receiving media, but the permeability of FP was greater for MP-AzeFlu during hours 0 to 6, suggesting faster absorption for MP-AzeFlu. No indications of compromised tissue integrity were found in any of the tested cells.Conclusion: The higher and more rapid penetration of FP from MP-AzeFlu supports the use of MP-AzeFlu for patients with AR, particularly when prioritizing fast and pronounced symptom relief.Keywords: absorption, allergic rhinitis, azelastine hydrochloride, mucosal penetration, pharmacology

Published
2020

14. Reducing Fungal Exposure Critical for Treating Rhinosinusitis with or without Polyps [Response to Letter]

Author

Bachert C, Bhattacharyya N, Desrosiers M, and Khan AH

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Claus Bachert, 1, 2 Neil Bhattacharyya, 3 Martin Desrosiers, 4 Asif H Khan 1, 5 1Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; 4Centre De Recherche Du Centre Hospitalier De l’Université De Montréal (CRCHUM), Montreal, QC, Canada; 5Sanofi, Chilly–Mazarin, FranceCorrespondence: Claus Bachert Email claus.bachert@ugent.be We thank Dr Curtis for his interest in our article, 1 and welcome the opportunity to address the putative role of molds and fungi in chronic rhinosinusitis (CRS).The potential contribution of fungi to the pathophysiology of CRS has been a focus of investigation many years back, and showed strong variation depending on the environment and climate. 2,3 The emerging understanding that the nose and sinuses naturally host a microbiome including viruses, bacteria, and fungi, suggests that the presence of microorganisms is itself not a key etiological factor in CRS. 4 Moreover, there is a lack of convincing immunological data to link fungi to the disease process in the great majority of CRS cases. 5 Consistent with this understanding, a 2018 Cochrane Review found no good evidence that oral or topical antifungals have a positive effect of quality of life, symptoms, or signs of disease in patients with CRS.6 Indeed, consensus guidelines advise against the use of antifungals in CRS. 4 This is in response to the Letter to the Editor View the original paper by Bachert and colleagues

Published
2021

15. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Bousquet, J., Hellings, P.W., Aberer, W., Agache, I., Akdis, C.A., Akdis, M., Alberti, M.R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B.A., Basagana, X., Bateman, E.D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E.H., Bergmann, K.C., Bennoor, K.S., Benson, M., Bertorello, L., Białoszewski, A.Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevich, C.S., Bosse, I., Bouchard, J., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briedis, V., Brightling, C.E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M.A., Camargos, P.A.M., Camuzat, T., Canfora, G., Canonica, G.W., Cardona, V., Carlsen, K.H., Carreiro-Martins, P., Carriazo, A.M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A.M., Chavannes, N.H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F., Costa, E., Costa-Dominguez, M.C., Courbis, A.L., Cox, L., Crescenzo, M., Cruz, A.A., Custovic, A., Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J.A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M.G., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Du Toit, G., Dykewicz, M.S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W.J., Fonseca, J.A., Fontaine, J.F., Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C.Y., Garcia-Cruz, M.H., Gemicioğlu, B., Genova, S., George, C., Gereda, J.E., Gerth van Wijk, R., Gomez, R.M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N.A., Gutter, Z., Guzmán, M.A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J.O.'B., Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J.C., Jares, E.J., Jassem, E., Johnston, S.L., Joos, G., Jung, K.S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A.F., Karjalainen, J., Kardas, P., Keil, T., Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M.L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L.T.T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R., Lourenço, O., Luna-Pech, J.A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R., Maspero, J.F., Mathieu-Dupas, E., Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F.F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D., O'Hehir, R.E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G.L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N.G., Park, H.S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J.L., Pereira, A.M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R.E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, H.J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F.S., Shamai, S., Sheikh, A., Sierra, M., Simons, F.E.R., Siroux, V., Sisul, J.C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P.V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M.T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M.T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D.Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D.M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B.P., Yiallouros, P.K., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zhang, L., Zhong, N., Zernotti, M.E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-François, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T.T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlos, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zuberbier, Torsten

Published
2019
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18. Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study

Author

Samreth, D., Arnavielhe, S., Ingenrieth, F., Bedbrook, A., Onorato, G.L., Murray, R., Almeida, R., Mizani, M.A., Fonseca, J., Costa, E., Malva, J., Morais-Almeida, M., Pereira, A.M., Todo-Bom, A., Menditto, E., Stellato, C., Ventura, M.T., Larenas-Linnemann, D., Fuentes-Pérez, J-M., Huerta-Villalobos, Y.R., Cruz, A.A., Stelmach, R., da Silva, J., Emuzyte, R., Kvedariene, V., Valiulis, A., Annesi-Maesano, I., Bosse, I., Demoly, P., Devillier, P., Fontaine, J.F., Kuna, P., Samolinski, B., Klimek, L., Mösges, R., Pfaar, O., Shamai, S., Bewick, M., Ryan, D., Sheikh, A., Anto, J.M., Cardona, V., Mullol, J., Valero, A., Chavannes, N.H., Fokkens, W.J., Reitsma, S., Roller-Wirnsberger, R.E., Tomazic, P.V., Haahtela, T., Toppila-Salmi, S., Valovirta, E., Makris, M., Papadopoulos, N.G., Prokopakis, E.P., Psarros, F., Gemicioğlu, B., Yorgancioglu, A., Bindslev-Jensen, C., Eller, E., Kull, I., Wickman, M., Bachert, C., Hellings, P.W., Pugin, B., Bosnic-Anticevich, S., O’Hehir, R.E., Kolek, V., Sova, M., Wehner, K., De Vries, G., van Eerd, M., Laune, D., Wittmann, J., Bousquet, J., and Poncelet, P., the MASK study group

Published
2018
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20. Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement

Author

Hellings, P. W., Pugin, B., Mariën, G., Bachert, C., Breynaert, C., Bullens, D. M., Ceuppens, J. L., Clement, G., Cox, T., Ebo, D., Gevaert, P., Halewyck, S., Hox, V., Ladha, K., Jacobs, R., Rombaux, P., Schrijvers, R., Speleman, K., Van der Brempt, X., Van Gerven, L., Vanderveken, O., Verhaeghe, B., Vierstraete, K., Vlaminck, S., Watelet, J. -B., Bousquet, J., and Seys, S. F.

Published
2019
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21. Eosinophils and tissue remodeling: relevance to airway disease

Author

Siddiqui, S, Bachert, C, Bjermer, L, Buchheit, KM, Castro, M, Qin, Y, Rupani, H, Sagara, H, Howarth, P, and Taillé, C

Abstract

The ability of human tissue to reorganize and restore its existing structure underlies tissue homeostasis in the healthy airways, but in disease can persist without normal resolution, leading to an altered airway structure. Eosinophils play a cardinal role in airway remodeling both in health and disease, driving epithelial homeostasis and extracellular matrix turnover. Physiological consequences associated with eosinophil-driven remodeling include impaired lung function and reduced bronchodilator reversibility in asthma, and obstructed airflow in chronic rhinosinusitis with nasal polyps (CRSwNP). Given the contribution of airway remodeling to the development and persistence of symptoms in airways disease, targeting remodeling is an important therapeutic consideration. Indeed, there is early evidence that eosinophil attenuation may reduce remodeling and disease progression in asthma. This review provides an overview of tissue remodeling in both health and airway disease with a particular focus on eosinophilic asthma and CRSwNP, as well as the role of eosinophils in these processes and the implications for therapeutic interventions. Areas for future research are also noted, to help improve our understanding of the homeostatic and pathological roles of eosinophils in tissue remodeling, which should aid the development of targeted and effective treatments for eosinophilic diseases of the airways.

Published
2023

23. Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma

Author

Megremis, S. (Spyridon), Constantinides, B. (Bede), Xepapadaki, P. (Paraskevi), Yap, C. F. (Chuan Fu), Sotiropoulos, A. G. (Alexandros G.), Bachert, C. (Claus), Finotto, S. (Susetta), Jartti, T. (Tuomas), Tapinos, A. (Avraam), Vuorinen, T. (Tytti), Andreakos, E. (Evangelos), Robertson, D. L. (David L.), Papadopoulos, N. G. (Nikolaos G.), Megremis, S. (Spyridon), Constantinides, B. (Bede), Xepapadaki, P. (Paraskevi), Yap, C. F. (Chuan Fu), Sotiropoulos, A. G. (Alexandros G.), Bachert, C. (Claus), Finotto, S. (Susetta), Jartti, T. (Tuomas), Tapinos, A. (Avraam), Vuorinen, T. (Tytti), Andreakos, E. (Evangelos), Robertson, D. L. (David L.), and Papadopoulos, N. G. (Nikolaos G.)

Abstract

Asthma development and exacerbation is linked to respiratory virus infections. There is limited information regarding the presence of viruses during non-exacerbation/infection periods. We investigated the nasopharyngeal/nasal virome during a period of asymptomatic state, in a subset of 21 healthy and 35 asthmatic preschool children from the Predicta cohort. Using metagenomics, we described the virome ecology and the cross-species interactions within the microbiome. The virome was dominated by eukaryotic viruses, while prokaryotic viruses (bacteriophages) were independently observed with low abundance. Rhinovirus B species consistently dominated the virome in asthma. Anelloviridae were the most abundant and rich family in both health and asthma. However, their richness and alpha diversity were increased in asthma, along with the co-occurrence of different Anellovirus genera. Bacteriophages were richer and more diverse in healthy individuals. Unsupervised clustering identified three virome profiles that were correlated to asthma severity and control and were independent of treatment, suggesting a link between the respiratory virome and asthma. Finally, we observed different cross-species ecological associations in the healthy versus the asthmatic virus-bacterial interactome, and an expanded interactome of eukaryotic viruses in asthma. Upper respiratory virome “dysbiosis” appears to be a novel feature of pre-school asthma during asymptomatic/non-infectious states and merits further investigation.

Published
2023

24. Empfehlungen zur Überprüfung der Wirksamkeit und Verlaufsdokumentation von Mepolizumab bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) im deutschen Gesundheitssystem – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)

Author

Klimek, L., additional, Förster-Ruhrmann, U., additional, Olze, H., additional, Beule, A. G., additional, Chaker, A. M., additional, Hagemann, J., additional, Huppertz, T., additional, Hoffmann, T. K., additional, Dazert, S., additional, Deitmer, T., additional, Strieth, S., additional, Wrede, H., additional, Schlenter, W., additional, Welkoborsky, H. J., additional, Wollenberg, B., additional, Becker, S., additional, Bärhold, F., additional, Klimek, F., additional, Casper, I., additional, Zuberbier, J., additional, Rudack, C., additional, Cuevas, M., additional, Hintschich, C. A., additional, Guntinas-Lichius, O., additional, Stöver, T., additional, Bergmann, C., additional, Werminghaus, P., additional, Pfaar, O., additional, Gosepath, J., additional, Gröger, M., additional, Beutner, C., additional, Laudien, M., additional, Weber, R. K., additional, Hildenbrand, T., additional, Hoffmann, A. S., additional, and Bachert, C., additional

Published
2023
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26. Evaluating treatment response to mepolizumab in patients with severe CRSwNP

Author

Hopkins, C., primary, Han, J.K., additional, Lund, V.J., additional, Bachert, C., additional, Fokkens, W.J., additional, Diamant, Z., additional, Mullol, J., additional, Sousa, A.R., additional, Smith, S.G., additional, Yang, S., additional, Mayer, B., additional, Yancey, S.W., additional, Chan, R.H., additional, and Lee, S.E., additional

Published
2023
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28. Additional file 1 of Association between outdoor air pollution and chronic rhinosinusitis patient reported outcomes

Author

Peeters, S., Wang, C., Bijnens, E. M., Bullens, D. M. A., Fokkens, W. J., Bachert, C., Hellings, P. W., Nawrot, T. S., and Seys, S. F.

Abstract

Additional file 1: Figure S1. Workflow depicting hierarchical model build-up and selection process. Figure S2. Variation in VAS of the total CRS symptoms per month. Figure S3. Relationship between CRS symptom severity and outdoor air pollution for the spring-summer population. Figure S4. Relationship between CRS symptom severity and outdoor air pollution for the fall - winter population. Table S1. Spearman’s rank correlation for same pollutants on adjacent lag days. Table S2. Spearman’s rank correlation for different pollutants on lag day 0. Table S3. AIC for model selection of the adjusted spring-summer population.

Published
2023
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29. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2017
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31. Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement

Author

Hellings, P. W., Fokkens, W. J., Bachert, C., Akdis, C. A., Bieber, T., Agache, I., Bernal‐Sprekelsen, M., Canonica, G. W., Gevaert, P., Joos, G., Lund, V., Muraro, A., Onerci, M., Zuberbier, T., Pugin, B., Seys, S. F., Bousquet, J., Aberer, W, Agache, I, Akdis, CA, Akdis, M, Alobid, I, Ankri, J, Annesi‐Maesano, I, Ansotegui, IJ, Anto, JM, Arnavielhe, S, Arshad, H, Asarnoj, A, Avolio, F, Bachert, C, Bachert, C, Baiardini, I, Barbagallo, M, Barbara, C, Baroody, F, Bateman, ED, Bedbrook, A, Beghé, B, Bel, EH, Bennoor, KS, Benson, M, Bergmann, KC, Bewick, M, Bialoszewski, AZ, Bieber, T, Bindslev‐Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, AL, Bonini, M, Bonini, S, Bosnic‐Anticevich, S, Bosse, I, Bouchard, J, Boulet, LP, Bourret, R, Bousquet, J, Bousquet, PJ, Braido, F, Briggs, AH, Brightling, CE, Brozek, J, Bucca, C, Buhl, R, Bunu, C, Burte, E, Bush, A, Caballero‐Fonseca, F, Caimmi, DP, Calderon, MA, Camargos, PA, Camuzat, T, Canonica, GW, Cardona, V, Carlsen, KH, Carr, W, Carreiro‐Martins, P, Carriazo, AM, Casale, T, Cepeda Sarabia, AM, Cervin, A, Cesari, M, Chatzi, L, Chavannes, NH, Chiron, R, Chivato, T, Chkhartishvili, E, Chuchalin, AG, Chung, KF, Ciprandi, G, Cohen, N, Conzález Diaz, S, Cox, L, Crooks, G, Cruz, AA, Custovic, A, Dahl, R, Dahlen, SE, Darsow, U, De Carlo, G, De Manuel Keenoy, E, de Sousa, JC, De Vries, G, Dedeu, T, Deleanu, D, Demoly, P, Denburg, JA, Devillier, P, Didier, A, Dinh‐Xuan, AT, Dokic, D, Douagui, H, Douglas, R, Dray, G, Du Toit, G, Dubakiene, R, Durham, SR, Dykewicz, MS, Eklund, P, El‐Gamal, Y, Ellers, E, Emuzyte, R, Farrell, J, Fink Wagner, A, Fiocchi, A, Fletcher, M, Fokkens, WJ, Fonseca, J, Forastiere, F, Gaga, M, Gamkrelidze, A, Gemicioğlu, B, Georgalas, C, Gereda, JE, Gevaert, P, Goossens, H, Grisle, I, Guldemond, NA, Gutter, Z, Guzmán, MA, Haahtela, T, Harvey, R, Heinrich, J, Hellings, PW, Hellings, PW, Hellquist‐Dahl, B, Hopkins, C, Horak, F, Hourihane, JO, Humbert, M, Hyland, M, Iaccarino, G, Illario, M, Jares, EJ, Jeandel, C, Johnston, SL, Jonquet, O, Joos, G, Joos, G, Jung, KS, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalogjera, L, Kalyoncu, AF, Kardas, P, Keil, T, Keith, PK, Kerkhof, M, Kern, B, Kerstjens, HA, Khaitov, M, Khaltaev, N, Klimek, L, Kogevinas, M, Kolek, V, Koppelman, GH, Kowalski, M, Kowalski, ML, Kuitunen, M, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Larenas‐Linnemann, D, Lau, S, Laune, D, Le, LT, Li, J, Lieberman, P, Lipworth, B, Lodrup Carlsen, KC, Louis, R, Lund, VJ, Lupinek, C, MacNee, W, Magar, Y, Magnan, A, Mahboub, B, Maier, D, Majer, I, Malva, J, Manning, P, Marshall, GD, Masjedi, MR, Mathieu‐Dupas, E, Maurer, M, Mavale‐Manuel, S, Melén, E, Melo‐Gomes, E, Meltzer, EO, Mercier, J, Merk, H, Miculinic, N, Mihaltan, F, Milenkovic, B, Millot‐Keurinck, J, Mohammad, Y, Momas, I, Morais‐Almeida, M, Mösges, R, Mullol, J, Mullol, J, Muraro, A, Murray, R, Naclerio, R, Nadif, R, Namazova‐Baranova, L, Neffen, H, Nekam, K, Nieto, A, Niggemann, B, Nogueira‐Silva, L, Nogues, M, Nyembue, TD, OʼHehir, RE, Ohta, K, Okamoto, Y, Okubo, K, Olive‐Elias, M, Ouedraogo, S, Paggiaro, P, Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Papi, A, Park, HS, Passalacqua, G, Pawankar, R, Pedersen, S, Pereira, AM, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Pohl, W, Popov, TA, Portejoie, F, Postma, D, Potter, P, Poulsen, LK, Price, D, Price, D, Rabe, KF, Raciborski, F, Riechelmann, H, Robalo‐Cordeiro, C, Roberts, G, Rodenas, F, Rodriguez‐Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado‐Pinto, J, Rosario, N, Rottem, M, Ryan, D, Samolinski, B, Sanchez‐Borges, M, Sastre‐Dominguez, J, Scadding, GK, Schlosser, R, Schmid‐Grendelmeier, P, Schunemann, HJ, Scichilone, N, Senior, B, Serrano, E, Sheikh, A, Shields, M, Simons, FER, Siroux, V, Sisul, JC, Skrindo, I, Smit, HA, Solé, D, Sooronbaev, T, Spranger, O, Stellato, C, Stelmach, R, Sterk, PJ, Strandberg, T, Sunyer, J, Thijs, C, Thomas, M, Todo‐Bom, A, Tomazic, PV, Toskala, E, Triggiani, M, Valenta, R, Valero, A, Valiulis, A, Valovirta, E, van Eerd, M, van Ganse, E, van Hage, M, van Wick, RG, Vandenplas, O, Varona, LL, Vazankari, T, Vellas, B, Ventura, MT, Vezzani, G, Viegi, G, Voegels, R, Vontetsianos, T, Wagenmann, M, Wahn, U, Walker, S, Wang, DY, Wang, Y, Werfel, T, Whalley, B, Wickman, M, Williams, DM, Williams, S, Wilson, N, Wormald, PJ, Wright, J, Yawn, BP, Yiallouros, PK, Yorgancioglu, A, Young, I, Yusuf, OM, Zaidi, A, Zar, HJ, Zernotti, ME, Zhang, L, Zhong, N, Zidarn, M, and Zuberbier, T

Published
2017
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33. Empfehlungen zur Überprüfung der Wirksamkeit und Verlaufsdokumentation von Dupilumab bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) im deutschen Gesundheitssystem

Author

Klimek, L., additional, Förster-Ruhrmann, U., additional, Olze, H., additional, Beule, A. G., additional, Chaker, A. M., additional, Hagemann, J., additional, Huppertz, T., additional, Hoffmann, T. K., additional, Dazert, S., additional, Deitmer, T., additional, Strieth, S., additional, Wrede, H., additional, Schlenter, W., additional, Welkoborsky, H. J., additional, Wollenberg, B., additional, Becker, S., additional, Klimek, F., additional, Sperl, A., additional, Casper, I., additional, Zuberbier, J., additional, Rudack, C., additional, Cuevas, M., additional, Hintschich, C. A., additional, Guntinas-Lichius, O., additional, Stöver, T., additional, Bergmann, C., additional, Pfaar, O., additional, Gosepath, J., additional, Gröger, M., additional, Beutner, C., additional, Laudien, M., additional, Weber, R. K., additional, Hildenbrand, T., additional, Hoffmann, A. S., additional, and Bachert, C., additional

Published
2022
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35. The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study

Author

Bousquet, J., Arnavielhe, S., Bedbrook, A., Fonseca, J., Morais Almeida, M., Todo Bom, A., Annesi‐Maesano, I., Caimmi, D., Demoly, P., Devillier, P., Siroux, V., Menditto, E., Passalacqua, G., Stellato, C., Ventura, M. T., Cruz, A. A., Sarquis Serpa, F., da Silva, J., Larenas‐Linnemann, D., Rodriguez Gonzalez, M., Burguete Cabañas, M. T., Bergmann, K. C., Keil, T., Klimek, L., Mösges, R., Shamai, S., Zuberbier, T., Bewick, M., Price, D., Ryan, D., Sheikh, A., Anto, J. M., Mullol, J., Valero, A., Haahtela, T., Valovirta, E., Fokkens, W. J., Kuna, P., Samolinski, B., Bindslev‐Jensen, C., Eller, E., Bosnic‐Anticevich, S., OʼHehir, R. E., Tomazic, P. V., Yorgancioglu, A., Gemicioglu, B., Bachert, C., Hellings, P. W., Kull, I., Melén, E., Wickman, M., van Eerd, M., and De Vries, G.

Published
2018
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36. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA‐ARIA) ‐ EIP on AHA Twinning Reference Site (GARD research demonstration project)

Author

Bousquet, J., Agache, I., Aliberti, M. R., Angles, R., Annesi‐Maesano, I., Anto, J. M., Arnavielhe, S., Asayag, E., Bacci, E., Bedbrook, A., Bachert, C., Baroni, I., Barreto, B. A., Bedolla‐Barajas, M., Bergmann, K. C., Bertorello, L., Bewick, M., Bieber, T., Birov, S., Bindslev‐Jensen, C., Blua, A., Bochenska Marciniak, M., Bogus‐Buczynska, I., Bosnic‐Anticevich, S., Bosse, I., Bourret, R., Bucca, C., Buonaiuto, R., Burguete Cabanas, M. T., Caillaud, D., Caimmi, D. P., Caiazza, D., Camargos, P., Canfora, G., Cardona, V., Carriazo, A. M., Cartier, C., Castellano, G., Chavannes, N. H., Cecci, L., Ciaravolo, M. M., Cingi, C., Ciceran, A., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés‐Grimaldo, R. M., Corti, F., Costa, E., Courbis, A. L., Cousein, E., Cruz, A. A., Custovic, A., Cvetkovski, B., Dario, C., da Silva, J., Dauvilliers, Y., De Blay, F., Dedeu, T., De Feo, G., De Martino, B., Demoly, P., De Vries, G., Di Capua Ercolano, S., Di Carluccio, N., Doulapsi, M., Dray, G., Dubakiene, R., Eller, E., Emuzyte, R., Espinoza‐Contreras, J. G., Estrada‐Cardona, A., Farrell, J., Farsi, A., Ferrero, J., Fokkens, W. J., Fonseca, J., Fontaine, J. F., Forti, S., Gálvez‐Romero, J. L., García‐Cobas, C. I., Garcia Cruz, M. H., Gemicioğlu, B., Gerth van Wijk, R., Guidacci, M., Gómez‐Vera, J., Guldemond, N. A., Gutter, Z., Haahtela, T., Hajjam, J., Hellings, P. W., Hernández‐Velázquez, L., Illario, M., Ivancevich, J. C., Jares, E., Joos, G., Just, J., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Keil, T., Khaltaev, N., Klimek, L., Kritikos, V., Kull, I., Kuna, P., Kvedariene, V., Kolek, V., Krzych‐Fałta, E., Kupczyk, M., Lacwik, P., La Grutta, S., Larenas‐Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Lessa, M., Levato, G., Lewis, L., Lieten, I., Lipiec, A., Louis, R., Luna‐Pech, J. A., Magnan, A., Malva, J., Maspero, J. F., Matta‐Campos, J. J., Mayora, O., Medina‐Ávalos, M. A., Melén, E., Menditto, E., Millot‐Keurinck, J., Moda, G., Morais‐Almeida, M., Mösges, R., Mota‐Pinto, A., Mullol, J., Muraro, A., Murray, R., Noguès, M., Nalin, M., Napoli, L., Neffen, H., OʼHehir, R. E., Onorato, G. L., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Pozzi, A. C., Prokopakis, E., Pugin, B., Raciborski, F., Rimmer, J., Rizzo, J. A., Robalo‐Cordeiro, C., Rodríguez‐González, M., Rolla, G., Roller‐Wirnsberger, R. E., Romano, A., Romano, M., Romano, M. R., Salimäki, J., Samolinski, B., Serpa, F. S., Shamai, S., Sierra, M., Sova, M., Sorlini, M., Stellato, C., Stelmach, R., Strandberg, T., Stroetmann, V., Stukas, R., Szylling, A., Tan, R., Tibaldi, V., Todo‐Bom, A., Toppila‐Salmi, S., Tomazic, P., Trama, U., Triggiani, M., Valero, A., Valovirta, E., Valiulis, A., van Eerd, M., Vasankari, T., Vatrella, A., Ventura, M. T., Verissimo, M. T., Viart, F., Williams, S., Wagenmann, M., Wanscher, C., Westman, M., Wickman, M., Young, I., Yorgancioglu, A., Zernotti, E., Zuberbier, T., Zurkuhlen, A., De Oliviera, B., and Senn, A.

Published
2018
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37. Validation of the MASK‐rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control

Author

Caimmi, D., Baiz, N., Tanno, L. K., Demoly, P., Arnavielhe, S., Murray, R., Bedbrook, A., Bergmann, K. C., De Vries, G., Fokkens, W. J., Fonseca, J., Haahtela, T., Keil, T., Kuna, P., Mullol, J., Papadopoulos, N., Passalacqua, G., Samolinski, B., Tomazic, P. V., Valiulis, A., van Eerd, M., Wickman, M., Annesi‐Maesano, I., Bousquet, J., Agache, I, Angles, R, Anto, JM, Asayag, E, Bacci, E, Bachert, C, Baroni, I, Barreto, BA, Bedolla‐Barajas, M, Bertorello, L, Bewick, M, Bieber, T, Birov, S, Bindslev‐Jensen, C, Blua, A, Bochenska Marciniak, M, Bogus‐Buczynska, I, Bosnic‐Ancevich, S, Bosse, I, Bourret, R, Bucca, C, Buonaiuto, R, Caiazza, D, Caillot, D, Caimmi, DP, Camargos, P, Canfora, G, Cardona, V, Carriazo, AM, Cartier, C, Castellano, G, Chavannes, NH, Ciaravolo, MM, Cingi, C, Ciceran, A, Colas, L, Colgan, E, Coll, J, Conforti, D, Correira de Sousa, J, Cortés‐Grimaldo, RM, Corti, F, Costa, E, Courbis, AL, Cruz, A, Custovic, A, Dario, C, da Silva, M, Dauvilliers, Y, De Blay, F, Dedeu, T, De Feo, G, De Martino, B, Di Capua, S, Di Carluccio, N, Dray, G, Dubakiene, R, Eller, E, Emuzyte, R, Espinoza‐Contreras, JM, Estrada‐Cardona, A, Farrell, J, Ferrero, J, Fontaine, JF, Forti, S, Gálvez‐Romero, JL, Garcia Cruz, MH, García‐Cobas, CI, Gemicioğlu, B, Gerth van Wijck, R, Guidacci, M, Gómez‐Vera, J, Guldemond, NA, Gutter, Z, Hajjam, J, Hellings, P, Hernández‐Velázquez, L, Illario, M, Ivancevich, JC, Jares, E, Joos, G, Just, J, Kalayci, O, Kalyoncu, AF, Karjalainen, J, Khaltaev, N, Klimek, L, Kull, I, Kuna, TP, Kvedariene, V, Kolek, V, Krzych‐Fałta, E, Kupczyk, M, Lacwik, P, Larenas‐Linnemann, D, Laune, D, Lauri, D, Lavrut, J, Lessa, M, Levato, G, Lewis, L, Lieten, I, Lipiec, A, Louis, R, Luna‐Pech, JA, Magnan, A, Malva, J, Maspero, JF, Mayora, O, Medina‐Ávalos, MA, Melen, E, Menditto, E, Millot‐Keurinck, J, Moda, G, Morais‐Almeida, M, Mösges, R, Mota‐Pinto, A, Muraro, A, Noguès, M, Nalin, M, Napoli, L, Neffen, H, OʼHehir, R, Olivé Elias, M, Onorato, G, Palkonen, S, Pépin, JL, Pereira, AM, Persico, M, Pfaar, O, Pozzi, AC, Prokopakis, EP, Raciborski, F, Rizzo, JA, Robalo‐Cordeiro, C, Rodríguez‐González, M, Rolla, G, Roller‐Wirnsberger, RE, Romano, A, Romano, M, Salimäki, J, Serpa, FS, Shamai, S, Sierra, M, Sova, M, Sorlini, M, Stellato, C, Stelmach, R, Strandberg, T, Stroetman, V, Stukas, R, Szylling, A, Tibaldi, V, Todo‐Bom, A, Toppila‐Salmi, S, Tomazic, P, Trama, U, Triggiani, M, Valero, A, Valovirta, E, van Eerd, M, Vasankari, T, Vatrella, A, Ventura, MT, Verissimo, MT, Viart, F, Williams, S, Wagenmann, M, Wanscher, C, Westman, M, Young, I, Yorgancioglu, A, Zernotti, E, Zurbierber, T, Zurkuhlen, A, De Oliviera, B, and Senn, A

Published
2017
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40. EUFOREA treatment algorithm for allergic rhinitis.

Author

Hellings P.W., Bachert C., Bjermer L., Canonica G.W., Cardell L.O., Carney A.S., Constantinidis J., Deneyer L., Diamant Z., Durham S., Gevaert P., Harvey R., Hopkins C., Kjeldsen A., Klimek L., Lund V.J., Price D., Rimmer J., Ryan D., Roberts G., Sahlstrand-Johnson P., Salmi S., Samji M., Scadding G., Smith P., Steinsvik A., Wagenmann M., Seys S., Wahn U., Fokkens W.J., Hellings P.W., Bachert C., Bjermer L., Canonica G.W., Cardell L.O., Carney A.S., Constantinidis J., Deneyer L., Diamant Z., Durham S., Gevaert P., Harvey R., Hopkins C., Kjeldsen A., Klimek L., Lund V.J., Price D., Rimmer J., Ryan D., Roberts G., Sahlstrand-Johnson P., Salmi S., Samji M., Scadding G., Smith P., Steinsvik A., Wagenmann M., Seys S., Wahn U., and Fokkens W.J.

Published
2022

42. Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers

Author

Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), Akdis, C. A. (Cezmi A.), Maurer, D. J. (Debbie J.), Liu, C. (Chengyao), Xepapadaki, P. (Paraskevi), Stanic, B. (Barbara), Bachert, C. (Claus), Finotto, S. (Susetta), Gao, Y.-D. (Ya-Dong), Graser, A. (Anna), Jartti, T. (Tuomas), Kistler, W. (Walter), Kowalski, M. (Marek), Lukkarinen, H. (Heikki), Pasioti, M. (Maria), Tan, G. (Ge), Villiger, M. (Michael), Zhang, L. (Luo), Zhang, N. (Nan), Akdis, M. (Mübeccel), Papadopoulos, N. G. (Nikolaos G.), and Akdis, C. A. (Cezmi A.)

Abstract

Background: The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical activity and daily TV attendance, to assess its role on asthma control and immune responses to various immune stimulants. Methods: Weekly physical activity and daily television attendance were obtained from questionnaires at inclusion of the PreDicta study. PBMC cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C, and zymosan. A panel of cytokines was measured and quantified in cell culture supernatants using luminometric multiplex immunofluorescence beads-based assay. Results: Asthmatic preschoolers showed significantly more TV attendance than their healthy peers (58.6% vs. 41.5% 1–3 h daily and only 25.7% vs. 47.2% ≤1 h daily) and poor asthma control was associated with less frequent physical activity (PA) (75% no or occasional activity in uncontrolled vs. 20% in controlled asthma; 25% ≥3 times weekly vs. 62%). Asthmatics with increased PA exhibited elevated cytokine levels in response to polyclonal stimulants, suggesting a readiness of circulating immune cells for type 1, 2, and 17 cytokine release compared to subjects with low PA and high TV attendance. This may also represent a proinflammatory state in high PA asthmatic children. Low physical activity and high TV attendance were associated with a decrease in proinflammatory cytokines. Proinflammatory cytokines were correlating with each other in in vitro immune responses of asthmatic children, but not healthy controls, this correlation was more pronounced in children with sedentary behavior. Conclusion: Asthmatic children show more sedentary behavior than healthy subjects, while poor asthma control is associated with a substantial decrease in physical activity. Our results suggest that asthmatic children may profit from regular exercise, as elevate

Published
2022

43. Sinonasal Epithelium

Author

Zhang, Luo; https://orcid.org/0000-0002-0910-9884, Bachert, Claus; https://orcid.org/0000-0003-4742-1665, Zhang, L ( Luo ), Bachert, C ( Claus ), Soyka, Michael; https://orcid.org/0000-0003-4179-4989, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Zhang, Luo; https://orcid.org/0000-0002-0910-9884, Bachert, Claus; https://orcid.org/0000-0003-4742-1665, Zhang, L ( Luo ), Bachert, C ( Claus ), Soyka, Michael; https://orcid.org/0000-0003-4179-4989, and Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X

Published
2022

44. Non‐allergic rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology

Author

Hellings, P. W., Klimek, L., Cingi, C., Agache, I., Akdis, C., Bachert, C., Bousquet, J., Demoly, P., Gevaert, P., Hox, V., Hupin, C., Kalogjera, L., Manole, F., Mösges, R., Mullol, J., Muluk, N. B., Muraro, A., Papadopoulos, N., Pawankar, R., Rondon, C., Rundenko, M., Seys, S. F., Toskala, E., Van Gerven, L., Zhang, L., Zhang, N., and Fokkens, W. J.

Published
2017
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45. Work productivity in rhinitis using cell phones: The MASK pilot study

Author

Bousquet, J., Bewick, M., Arnavielhe, S., Mathieu‐Dupas, E., Murray, R., Bedbrook, A., Caimmi, D. P., Vandenplas, O., Hellings, P. W., Bachert, C., Anto, J. M., Bergmann, K. C., Bindslev‐Jensen, C., Bosnic‐Anticevich, S., Bouchard, J., Canonica, G. W., Chavannes, N. H., Cruz, A. A., Dahl, R., Demoly, P., De Vries, G., Devillier, P., Fink‐Wagner, A., Fokkens, W. J., Fonseca, J., Guldemond, N. A., Haahtela, T., Hellqvist‐Dahl, B., Just, J., Keil, T., Klimek, L., Kowalski, M. L., Kuna, P., Kvedariene, V., Laune, D., Larenas‐Linnemann, D., Mullol, J., Pereira, A. M., Carreiro‐Martins, P., Melén, E., Morais‐Almeida, M., Nogueira‐Silva, L., OʼHehir, R. E., Papadopoulos, N. G., Passalacqua, G., Portejoie, F., Price, D., Ryan, D., Samolinski, B., Sheikh, A., Simons, F. E. R., Spranger, O., Todo Bom, A., Tomazic, P. V., Triggiani, M., Valero, A., Valovirta, E., Valiulis, A., van Eerd, M., Wickman, M., Young, I., and Zuberbier, T.

Published
2017
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