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11 results on '"Bachelier, Philippe"'

1. Long-term abdominal wall benefits of the laparoscopic approach in liver left lateral sectionectomy: a multicenter comparative study

Author

Darnis, Benjamin, Mohkam, Kayvan, Golse, Nicolas, Vibert, Eric, Cherqui, Daniel, Cauchy, François, Soubrane, Olivier, Regimbeau, Jean-Marc, Dembinski, Jeanne, Hardwigsen, Jean, Bachelier, Philippe, Laurent, Christophe, Truant, Stéphanie, Millet, Guillaume, Lesurtel, Mickaël, Boleslawksi, Emmanuel, and Mabrut, Jean-Yves

Published
2021
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3. Data from Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

Author

Maréchal, Raphaël, primary, Bachet, Jean-Baptiste, primary, Calomme, Annabelle, primary, Demetter, Pieter, primary, Delpero, Jean Robert, primary, Svrcek, Magali, primary, Cros, Jérôme, primary, Bardier-Dupas, Armelle, primary, Puleo, Francesco, primary, Monges, Geneviève, primary, Hammel, Pascal, primary, Louvet, Christophe, primary, Paye, François, primary, Bachelier, Philippe, primary, Le Treut, Yves Patrice, primary, Vaillant, Jean-Christophe, primary, Sauvanet, Alain, primary, André, Thierry, primary, Salmon, Isabelle, primary, Devière, Jacques, primary, Emile, Jean-François, primary, and Van Laethem, Jean-Luc, primary

Published
2023
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4. Supplementary Figures 1-3 from Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

Author

Maréchal, Raphaël, primary, Bachet, Jean-Baptiste, primary, Calomme, Annabelle, primary, Demetter, Pieter, primary, Delpero, Jean Robert, primary, Svrcek, Magali, primary, Cros, Jérôme, primary, Bardier-Dupas, Armelle, primary, Puleo, Francesco, primary, Monges, Geneviève, primary, Hammel, Pascal, primary, Louvet, Christophe, primary, Paye, François, primary, Bachelier, Philippe, primary, Le Treut, Yves Patrice, primary, Vaillant, Jean-Christophe, primary, Sauvanet, Alain, primary, André, Thierry, primary, Salmon, Isabelle, primary, Devière, Jacques, primary, Emile, Jean-François, primary, and Van Laethem, Jean-Luc, primary

Published
2023
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5. Supplementary Tables 1-6 from Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

Author

Maréchal, Raphaël, primary, Bachet, Jean-Baptiste, primary, Calomme, Annabelle, primary, Demetter, Pieter, primary, Delpero, Jean Robert, primary, Svrcek, Magali, primary, Cros, Jérôme, primary, Bardier-Dupas, Armelle, primary, Puleo, Francesco, primary, Monges, Geneviève, primary, Hammel, Pascal, primary, Louvet, Christophe, primary, Paye, François, primary, Bachelier, Philippe, primary, Le Treut, Yves Patrice, primary, Vaillant, Jean-Christophe, primary, Sauvanet, Alain, primary, André, Thierry, primary, Salmon, Isabelle, primary, Devière, Jacques, primary, Emile, Jean-François, primary, and Van Laethem, Jean-Luc, primary

Published
2023
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7. Long-term abdominal wall benefits of the laparoscopic approach in liver left lateral sectionectomy: a multicenter comparative study

Author

Darnis, Benjamin, primary, Mohkam, Kayvan, additional, Golse, Nicolas, additional, Vibert, Eric, additional, Cherqui, Daniel, additional, Cauchy, François, additional, Soubrane, Olivier, additional, Regimbeau, Jean-Marc, additional, Dembinski, Jeanne, additional, Hardwigsen, Jean, additional, Bachelier, Philippe, additional, Laurent, Christophe, additional, Truant, Stéphanie, additional, Millet, Guillaume, additional, Lesurtel, Mickaël, additional, Boleslawksi, Emmanuel, additional, and Mabrut, Jean-Yves, additional

Published
2020
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8. Severe postoperative complications decrease overall and disease free survival in pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Author

Lubrano, Jean, primary, Bachelier, Philippe, additional, Paye, François, additional, Le Treut, Yves Patrice, additional, Chiche, Laurence, additional, Sa-Cunha, Antonio, additional, Turrini, Olivier, additional, Menahem, Benjamin, additional, Launoy, Guy, additional, and Delpero, Jean-Robert, additional

Published
2018
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9. Sonic hedgehog and Gli1 expression predict outcomein resected pancreatic adenocarcinoma

Author

Marechal, Raphaël, Bachet, Jean-Baptiste, Calomme, Annabelle, Demetter, Pieter, Delpero, Jean Robert, Svrcek, Magali, Cros, Jérôme, Bardier-Dupas, Armelle, Puleo, Francesco, Monges, Geneviève, Hammel, Pascal, Louvet, Christophe, Paye, François, Bachelier, Philippe, Le Treut, Yves Patrice, Vaillant, Jean-Christophe, Sauvanet, Alain, André, Thierry, Salmon, Isabelle, Devière, Jacques, Emile, Jean-François, Van Laethem, Jean-Luc, Marechal, Raphaël, Bachet, Jean-Baptiste, Calomme, Annabelle, Demetter, Pieter, Delpero, Jean Robert, Svrcek, Magali, Cros, Jérôme, Bardier-Dupas, Armelle, Puleo, Francesco, Monges, Geneviève, Hammel, Pascal, Louvet, Christophe, Paye, François, Bachelier, Philippe, Le Treut, Yves Patrice, Vaillant, Jean-Christophe, Sauvanet, Alain, André, Thierry, Salmon, Isabelle, Devière, Jacques, Emile, Jean-François, and Van Laethem, Jean-Luc

Abstract

Purpose: Aberrant activation of the hedgehog (Hh) pathway is implicated in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. We investigated the prognostic and predictive value of four Hh signaling proteins and of the tumor stromal density. Experimental Design: Using tissue microarray and immunohistochemistry, the expression of Shh, Gli1, SMO, andPTCH1was assessed in 567 patients from three independent cohorts who underwent surgical resection for PDAC. In 82 patients, the tumor stromal index (SI) was calculated, and its association with overall survival (OS) and disease-free survival (DFS) was investigated. Results: Shh and Gli1 protein abundance were independent prognostic factors in resected PDACs; low expressors for those proteins experiencing a better OS and DFS. The combination of Shh and Gli1 levels was the most significant predictor for OS and defined 3 clinically relevant subgroups of patients with different prognosis (Gli1 and Shh low; HR set at 1 vs. 3.08 for Shh or Gli1 high vs. 5.69 for Shh and Gli1 high; P < 0.001). The two validating cohorts recapitulated the findings of the training cohort. After further stratification by lymph node status, the prognostic significance of combined Shh and Gli1 was maintained. The tumor SI was correlated with Shh levels and was significantly associated with OS (P = 0.023). Conclusions: Shh and Gli1 are prognostic biomarkers for patients with resected PDAC. Clin Cancer Res; 21(5); 1215-24., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

11. Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

Author

Maréchal, Raphaël, primary, Bachet, Jean-Baptiste, additional, Calomme, Annabelle, additional, Demetter, Pieter, additional, Delpero, Jean Robert, additional, Svrcek, Magali, additional, Cros, Jérôme, additional, Bardier-Dupas, Armelle, additional, Puleo, Francesco, additional, Monges, Geneviève, additional, Hammel, Pascal, additional, Louvet, Christophe, additional, Paye, François, additional, Bachelier, Philippe, additional, Le Treut, Yves Patrice, additional, Vaillant, Jean-Christophe, additional, Sauvanet, Alain, additional, André, Thierry, additional, Salmon, Isabelle, additional, Devière, Jacques, additional, Emile, Jean-François, additional, and Van Laethem, Jean-Luc, additional

Published
2015
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