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34 results on '"Bacciu, Salvatore"'

9. Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report

Author

Bacciu Salvatore, Zavota Laura, Rubino Pierangela, Laganà Bruno, Orsoni Jelka G, and Mora Paolo

Subjects
Medicine
Abstract

Abstract Background Rituximab is a monoclonal antibody inducing depletion of B lymphocytes and presently approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. Here is the first report of the use of this drug in a case of Cogan's syndrome (CS). Case Presentation a 25-year-old Italian woman was referred with conjunctival hyperaemia, interstitial keratitis, moderate bilateral sensorineural hearing loss accompanied by tinnitus, dizziness, nausea and vertigo, poorly responsive to oral and topical steroidal therapy. Diagnosis of typical CS was made. The administration of a combined immunosuppressive treatment resolved ocular inflammation, dizziness, nausea, and vertigo but gave little results in controlling progressive hearing loss. A noticeable improvement in hearing function was documented by pure tone audiometry after infusion of Rituximab. Discussion in CS, hearing function is often the most difficult parameter to control with therapy. A positive effect of Rituximab on was observed in our case. The drug also allowed to significantly reduce the number of adjuvant immunosuppressive medications.

Published
2010
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11. Pneumolabyrinth secondary to temporal bone fracture: a case report and review of the literature

Author

Bacciu, Andrea, Vincenti,Vincenzo, Chandra Prasad,Sampath, Tonni,Daniela, Ventura,Elisa, Bacciu,Salvatore, and Pasanisi,Enrico

Subjects
International Medical Case Reports Journal
Abstract

Andrea Bacciu,1 Vincenzo Vincenti,1 Sampath Chandra Prasad,1 Daniela Tonni,1 Elisa Ventura,2 Salvatore Bacciu,1 Enrico Pasanisi1 1Department of Clinical and Experimental Medicine, Unit of Audiology and Paediatric Otolaryngology, 2Department of Neuroradiology, University Hospital of Parma, Parma, Italy Abstract: Pneumolabyrinth following temporal bone fracture is an extremely rare condition. It results from air entering the inner ear when a communication between the air-filled middle ear spaces and inner ear is established. The imaging modality of choice for pneumolabyrinth is high-resolution computed tomography of the temporal bone. Treatment options include conservative management (bed rest, antibiotics, corticosteroids) or surgery (exploratory tympanotomy). We present the case of a 31-year-old female who had pneumolabyrinth secondary to a temporal bone fracture. The patient was treated surgically and made a full clinical recovery. Keywords: pneumolabyrinth, temporal bone fractures, head trauma

Published
2014

13. Pneumolabyrinth secondary to temporal bone fracture: a case report and review of the literature

Author

Bacciu,Andrea, Vincenti,Vincenzo, Chandra Prasad,Sampath, Tonni,Daniela, Ventura,Elisa, Bacciu,Salvatore, Pasanisi,Enrico, Bacciu,Andrea, Vincenti,Vincenzo, Chandra Prasad,Sampath, Tonni,Daniela, Ventura,Elisa, Bacciu,Salvatore, and Pasanisi,Enrico

Abstract

Andrea Bacciu,1 Vincenzo Vincenti,1 Sampath Chandra Prasad,1 Daniela Tonni,1 Elisa Ventura,2 Salvatore Bacciu,1 Enrico Pasanisi1 1Department of Clinical and Experimental Medicine, Unit of Audiology and Paediatric Otolaryngology, 2Department of Neuroradiology, University Hospital of Parma, Parma, Italy Abstract: Pneumolabyrinth following temporal bone fracture is an extremely rare condition. It results from air entering the inner ear when a communication between the air-filled middle ear spaces and inner ear is established. The imaging modality of choice for pneumolabyrinth is high-resolution computed tomography of the temporal bone. Treatment options include conservative management (bed rest, antibiotics, corticosteroids) or surgery (exploratory tympanotomy). We present the case of a 31-year-old female who had pneumolabyrinth secondary to a temporal bone fracture. The patient was treated surgically and made a full clinical recovery. Keywords: pneumolabyrinth, temporal bone fractures, head trauma

Published
2014

15. Pediatric cochlear implantation: an update

Author

Vincenti, Vincenzo, primary, Bacciu, Andrea, additional, Guida, Maurizio, additional, Marra, Francesca, additional, Bertoldi, Barbara, additional, Bacciu, Salvatore, additional, and Pasanisi, Enrico, additional

Published
2014
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22. Nasal Polyposis in Churg-Strauss Syndrome

Author

Bacciu, Andrea, primary, Buzio, Carlo, additional, Giordano, Davide, additional, Pasanisi, Enrico, additional, Vincenti, Vincenzo, additional, Mercante, Giuseppe, additional, Grasselli, Chiara, additional, and Bacciu, Salvatore, additional

Published
2008
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23. Ear, nose and throat manifestations of Churg-Strauss syndrome

Author

Bacciu, Andrea, primary, Bacciu, Salvatore, additional, Mercante, Giuseppe, additional, Ingegnoli, Francesca, additional, Grasselli, Chiara, additional, Vaglio, Augusto, additional, Pasanisi, Enrico, additional, Vincenti, Vincenzo, additional, Garini, Giovanni, additional, Ronda, Nicoletta, additional, Ferri, Teore, additional, Corradi, Domenico, additional, and Buzio, Carlo, additional

Published
2006
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27. Cochlear Implantation and Cogan Syndrome

Author

Pasanisi, Enrico, primary, Vincenti, Vincenzo, additional, Bacciu, Andrea, additional, Guida, Maurizio, additional, Berghenti, Teresa, additional, Barbot, Anna, additional, Orsoni, Jelka G., additional, and Bacciu, Salvatore, additional

Published
2003
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31. The windowed sound therapy: a new empirical approach for an effective personalized treatment of tinnitus.

Author

Lugli, Marco, Romani, Romano, Ponzi, Stefano, Bacciu, Salvatore, and Parmigiani, Stefano

Abstract

We auditorily stimulated patients affected by subjective tinnitus with broadband noise containing a notch around their tinnitus frequency. We assessed the long-term effects on tinnitus perception in patients listening to notched noise stimuli (referred to as windowed sound therapy [WST]) by measuring the variation of subjects' tinnitus loudness over a period of 2-12 months. We tested the effectiveness of WST using non-notched broadband noise and noise of water as control sound therapies. We found a significant long-term reduction of tinnitus loudness in subjects treated with notched noise but not in those treated with control stimulations. These results point to the importance of the personalized sound treatment of tinnitus sufferers for the development of an effective tinnitus sound therapy. [ABSTRACT FROM AUTHOR]

Published
2009

32. Molded Tympanic Heterografts

Author

Gamoletti, Roberto, Lanzarini, Paolo, Sanna, Mario, Zini, Carlo, and Bacciu, Salvatore

Abstract

The histologic appearance of the molded tympanic heterograft developed at the ENT Clinic of the University of Parma, Italy, is investigated with light and electron microscopy. Evaluation of the graft before insertion disclosed a unique structure of interwoven collagen bundles. Examination of grafted tympanic membrane showed a structure closely resembling the normal human tympanic membrane. The fate of the heterologous material and the host reaction to it are discussed in relation to histologic findings.

Published
1984
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33. Cogan's syndrome: Anti-Hsp70 antibodies are a serological marker in the typical form

Author

Chiara Bonaguri, Orsoni, Jelka, Russo, Annalisa, Rubino, Pierangela, Bacciu, Salvatore, Lippi, Giuseppe, Melegari, Alessandra, Zavota, Laura, Ghirardini, Stella, and Mora, Paolo

Subjects
Adult, Male, Chi-Square Distribution, Cogan’s syndrome, Autoimmunity, Sensitivity and Specificity, Hsp70, ocular inflammation, Cogan Syndrome, Humans, Female, HSP70 Heat-Shock Proteins, Child, Biomarkers, Aged, Autoantibodies
Abstract

Cogan's syndrome (CS) is a rare autoimmune vasculitis characterized by ocular inflammation and sensorineural hearing loss. CS is divided into a "typical" form with non-syphilitic interstitial keratitis and audiovestibular symptoms, and an "atypical" form with ocular involvement affecting structures other than the cornea. Anti-Hsp70 antibodies were found at variable levels in patients presenting with various forms of autoimmune sensorineural hearing loss (ASNHL).To assess the correlation between anti-Hsp70 antibodies and specific ASNHL subgroups.We divided 112 subjects into four groups: 14 subjects with typical CS, 24 with atypical CS, 55 with ASNHL, and 19 control subjects (healthy subjects and patients with systemic autoimmune diseases but no sensorineural hearing or audiovestibular alterations). Patients were tested for serological autoimmunity markers including anti-Hsp70.Positivity of the anti-Hsp70 antibody test was highest in the typical CS group (92.9%) and lowest in the control group (5.2%). The test was positive in 52.7% of patients in the ASNHL group and 16.6% in the atypical CS group. The paired comparison analysis between groups showed that sensitivity of anti-Hsp70 in the typical CS group was significantly higher, as compared to the other three study groups.Anti-Hsp70 antibodies can be considered a serological marker of "typical" CS. "Atypical" CS is conceivably a sort of "melting pot" of different forms of autoimmune diseases still characterized by ocular inflammation and sensorineural hearing loss but whose antigenic characteristics need to be further defined.

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