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382 results on '"Bacci, Gaetano"'

8. Palliative therapy for osteosarcoma

Author

Errani, Costantino, Longhi, Alessandra, Rossi, Giuseppe, Rimondi, Eugenio, Biazzo, Alessio, Toscano, Angelo, Alì, Nikolin, Ruggieri, Pietro, Alberghini, Marco, Picci, Piero, Bacci, Gaetano, and Mercuri, Mario

Published
2011
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11. Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution

Author

Palmerini, Emanuela, Staals, Eric L., Alberghini, Marco, Zanella, Licciana, Ferrari, Cristina, Benassi, Maria Serena, Picci, Piero, Mercuri, Mario, Bacci, Gaetano, and Ferrari, Sefano

Subjects
Sarcoma -- Care and treatment, Sarcoma -- Research, Synovial membranes -- Diseases, Synovial membranes -- Research, Radiotherapy -- Patient outcomes, Radiotherapy -- Research, Chemotherapy -- Patient outcomes, Chemotherapy -- Research, Cancer -- Chemotherapy, Cancer -- Patient outcomes, Cancer -- Research, Health
Published
2009

18. Neoadjuvant Chemotherapy With High-Dose Ifosfamide, High-Dose Methotrexate, Cisplatin, and Doxorubicin for Patients With Localized Osteosarcoma of the Extremity: A Joint Study by the Italian and Scandinavian Sarcoma Groups

Author

Ferrari, Stefano, Smeland, Sigbjorn, Mercuri, Mario, Bertoni, Franco, Longhi, Alessandra, Ruggieri, Pietro, Alvegard, Thor A., Picci, Piero, Capanna, Rodolfo, Bernini, Gabriella, Müller, Cristoph, Tienghi, Amelia, Wiebe, Thomas, Comandone, Alessandro, Böhling, Tom, Del Prever, Adalberto Brach, Brosjö, Otte, Bacci, Gaetano, and Sæter, Gunnar

Published
2005
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22. Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome

Author

Baldini, Nicola, Scotlandi, Katia, Barbanti-Brodano, Giovanni, Manara, Maria Cristina, Maurici, Daniela, Bacci, Gaetano, Bertoni, Franco, Picci, Piero, Sottili, Sandra, Campanacci, Mario, and Serra, Massimo

Subjects
Osteosarcoma -- Prognosis, Glycoproteins -- Physiological aspects
Abstract

High levels of P-glycoprotein in tumor cells of osteosarcoma appear to increase the risk of tumor relapse or death following surgery and chemotherapy. Osteosarcoma is a bone tumor that is often cancerous. Researchers studied the levels of the membrane pump P-glycoprotein in tumor cells of 92 patients with osteosarcoma who had surgery and chemotherapy. In 28 (30%) of the tumors, P-glycoprotein appeared at elevated levels in cells throughout the tumor. Tumors located at the end of bones closer to the torso tended to have higher P-glycoprotein levels. During a minimum follow-up of 63 months, the rate of tumor relapse or death during remission was 3.4 times higher in people with high P-glycoprotein levels. Poor response to chemotherapy also appeared to increase the likelihood of a poor outcome.

Published
1995

24. Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma

Author

Ferrari, Stefano, Bertoni, Franco, Zanella, Licciana, Setola, Elisabetta, Bacchini, Patrizia, Alberghini, Marco, Versari, Mechela, and Bacci, Gaetano

Subjects
Tumor markers -- Comparative analysis, Osteosarcoma -- Research, Osteosarcoma -- Development and progression, Lung cancer -- Research, Lung cancer -- Development and progression, Health
Published
2004

27. Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity

Author

Bacci, Gaetano, Bertoni, Franco, Longhi, Alessandra, Ferrari, Stefano, Forni, Christiana, Biagini, Roberto, Bacchini, Patrizia, Donati, Davide, Manfrini, Marco, Bernini, Gabriella, and Lari, Stefano

Subjects
Chemotherapy -- Methods, Osteosarcoma -- Risk factors, Osteosarcoma -- Care and treatment, Health
Published
2003

35. Neoadjuvant chemotherapy for Ewing's sarcoma of bone: no benefit observed after adding ifosfamide and etoposide to vincristine, actinomycin, cyclophosphamide, and doxorubicin in the maintenance phase - results of two sequential studies

Author

Bacci, Gaetano, Picci, Piero, Ferrari, Stefano, Mercuri, Mario, Brach del Prever, Adalberto, Rosito, Pasquale, Barbieri, Enza, Tienghi, Amelia, and Forni, Cristiana

Subjects
Ewing's sarcoma, Chemotherapy, Combination -- Evaluation, Health
Published
1998

36. Osteogenic sarcoma of the extremity with detectable lung metastases at presentation: results of treatment of 23 patients with chemotherapy followed by simultaneous resection of primary and metastatic lesions

Author

Bacci, Gaetano, Mercuri, Mario, Briccoli, Antonio, Ferrari, Stefano, Bertoni, Franco, Donati, Davide, Monti, Carlo, Zanoni, Antonio, Forni, Christiana, and Manfrini, Marco

Subjects
Osteosarcoma, Adjuvants, Pharmaceutic -- Evaluation, Metastasis -- Care and treatment, Antineoplastic agents -- Evaluation, Health
Published
1997

38. Primary chemotherapy and delayed surgery for nonmetastatic osteosarcoma of the extremities: results in 164 patients preoperatively treated with high doses of methotrexate followed by cisplatin and doxorubicin

Author

Bacci, Gaetano, Picci, Piero, Ferrari, Stefano, Ruggieri, Pietro, Casadei, Roberto, Tienghi, Amelia, Brach del Prever, Alberto, Gherlinzoni, Franco, Mercuri, Mario, and Monti, Carlo

Subjects
Osteosarcoma -- Care and treatment, Cancer -- Adjuvant treatment, Extremities (Anatomy), Methotrexate -- Dosage and administration, Cisplatin -- Dosage and administration, Doxorubicin -- Dosage and administration, Health
Published
1993

39. Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy

Author

Bacci, Gaetano, Picci, Piero, Ferrari, Stefano, Orlandi, Maurizio, Ruggieri, Pietro, Casadei, Roberto, Ferraro, Andrea, Biagini, Roberto, and Battistini, Alberto

Subjects
Osteosarcoma -- Prognosis, Cancer -- Adjuvant treatment, Chemotherapy -- Usage, Alkaline phosphatase -- Measurement, Health
Abstract

Background. It is known that many patients with osteosarcoma have high serum alkaline phosphatase (SAP) levels. The prognostic significance of this finding, however, is still controversial. Methods. The pretreatment SAP levels of 656 patients with osteosarcoma of the extremities (107 metastatic and 549 localized at presentation) were examined to evaluate whether the enzyme levels had a clinical value in predicting the course of the disease. Results. The percentage of patients with increased SAP levels was significantly higher in the metastatic group than in the group of patients with localized disease (91.5% versus 61.3%; P < 0.001). In the latter group, treated with adjuvant and neoadjuvant chemotherapy, the relapse rate was significantly higher in patients with elevated pretreatment SAP levels than in those with normal levels (55.1% versus 26.4% P < 0.001). Among patients with elevated SAP levels, the percentage of relapses was higher in patients with high levels of the enzyme in comparison with patients with moderately elevated values (66.4% versus 47% P < 0.05). After treatment, SAP levels almost always return to normal values, and a correlation between postoperative levels of the enzyme and prognosis could not be made. Conclusions. These data demonstrate that in osteosarcoma of the extremities, pretreatment SAP levels have a prognostic value and they should be considered when comparing the results achieved with different therapeutic protocols and in planning new randomized clinical trials. Cancer 1993; 71:1224-30.

Published
1993

41. Local and systemic control of Ewing's bone sarcoma family tumors of the ribs

Author

BRICCOLI, ANTONIO, Rocca M, Salone M, PALMERINI, EMANUELA, Balladelli A, Ferrari C, Di Fiore M, BACCI, GAETANO, Briccoli A, Rocca M, Salone M, Palmerini E, Balladelli A, Ferrari C, Di Fiore M, and Bacci G.

Subjects
Adult, Male, Adolescent, Bone Neoplasms, Ribs, Sarcoma, Ewing, Bone Neoplasm, Follow-Up Studie, Retrospective Studie, Antineoplastic Combined Chemotherapy Protocols, Fascia Lata, Chemotherapy, Humans, Ifosfamide, Neoplasm Metastasis, Child, Cyclophosphamide, Etoposide, Retrospective Studies, Bone Plate, Antineoplastic Combined Chemotherapy Protocol, Rib, Surgical Mesh, Neoadjuvant Therapy, Radiation therapy, Neoplasm Metastasi, Oncology, Thoracotomy, Doxorubicin, Vincristine, Child, Preschool, Dactinomycin, Surgery, Female, Radiotherapy, Adjuvant, Neoplasm Recurrence, Local, Ewing sarcoma family tumor, Bone Plates, Human, Follow-Up Studies
Abstract

Background: A retrospective analysis of the results and relapse pattern was evaluated in 34 patients with Ewing's family bone tumors (EFBT) treated at Rizzoli Institute with neoadjuvant chemotherapy between 1983 and 2003. Objectives: The aim of the study was to evaluate treatment strategy and compare our results with those obtained in other studies. Methods: Local treatment in these patients was radiotherapy alone in 4 cases, surgery alone in 13 and surgery followed by radiotherapy in 17. Results: Five-year event-free survival (EFS) was 44%, no different from that observed in another 558 patients with EFBT located in other sites treated in the same period with neoadjuvant chemotherapy protocols. Eighteen patients had a systemic relapse, followed by local relapse in two and one patient had a local relapse alone. EFS was significantly correlated to the time interval between onset symptoms and beginning of treatment and, in operated patients to histologic response to preoperative treatment. Conclusions: We conclude that EFBT of the ribs, when treated with neoadjuvant chemotherapy, have an outcome similar to that of patients with EFBT located in other sites. © 2009 Wiley-Liss, Inc.

Published
2009

42. High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions

Author

BACCI, GAETANO, BRICCOLI, ANTONIO, Rocca M., Salone M., Balladelli A., Ferrari S., PALMERINI, EMANUELA, Forni C., Bacci G., Rocca M., Salone M., Balladelli A., Ferrari S., Palmerini E., Forni C., and Briccoli A.

Abstract

BACKGROUND AND METHODS: Between 1986 and 2001, 162 patients with extremity osteosarcoma and lung metastases at presentation, were treated by neoadjuvant chemotherapy, simultaneous resection of primary and, when feasible, secondary lesions followed by chemotherapy. RESULTS: After neoadjuvant chemotherapy, metastases disappeared in 14 patients, 16 were judged unresectable by both our thoracic surgeons, 132 had primary tumors and lung metastases removed simultaneously. Removal of lung metastases was complete in 123 and incomplete in 9. Histologically lesions were benign in 32 patients. For the 100 patients simultaneously operated with histologically proven lung metastases, 5-year event-free survival (EFS) was 18.9%; 27.4% for the 91 who had a complete resection of pulmonary lesions and entered remission as opposed to none for 9 patients who had incomplete removal of lung nodules. Among these 91, 5-year EFS was significantly higher for patients with monolateral compared to bilateral lesions (27.1% vs. 7.9%, P < 0.02) and when only one to three metastatic nodules were present (40.0% vs. 13.3%, P < 0.0001). CONCLUSIONS: These different results, demonstrate that our treatment had a reasonable survival outcome whereas other groups continue to have dismal prognosis. More efforts should be made to improve survival by identifying new active agents or novel approaches with cellular molecular targets. (c) 2008 Wiley-Liss, Inc.

Published
2008

45. Neoadjuvant Chemotherapy With Methotrexate, Cisplatin, and Doxorubicin With or Without Ifosfamide in Nonmetastatic Osteosarcoma of the Extremity: An Italian Sarcoma Group Trial ISG/OS-1

Author

Ferrari, Stefano, primary, Ruggieri, Pietro, additional, Cefalo, Graziella, additional, Tamburini, Angela, additional, Capanna, Rodolfo, additional, Fagioli, Franca, additional, Comandone, Alessandro, additional, Bertulli, Rossella, additional, Bisogno, Gianni, additional, Palmerini, Emanuela, additional, Alberghini, Marco, additional, Parafioriti, Antonina, additional, Linari, Alessandra, additional, Picci, Piero, additional, and Bacci, Gaetano, additional

Published
2012
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46. Vincristine, Doxorubicin, Cyclophosfamide, Actinomycin D, Ifosfamide, and Etoposide in Adult and Pediatric Patients with Nonmetastatic Ewing Sarcoma. Final Results of a Monoinstitutional Study

Author

Ferrari, Stefano, primary, Palmerini, Emanuela, additional, Alberghini, Marco, additional, Staals, Eric, additional, Mercuri, Mario, additional, Barbieri, Enza, additional, Longhi, Alessandra, additional, Cantero, Laura, additional, Cesari, Marilena, additional, Abate, Massimo, additional, Balladelli, Alba, additional, Picci, Piero, additional, and Bacci, Gaetano, additional

Published
2010
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47. Synovial sarcoma

Author

Palmerini, Emanuela, primary, Staals, Eric L., additional, Alberghini, Marco, additional, Zanella, Licciana, additional, Ferrari, Cristina, additional, Benassi, Maria Serena, additional, Picci, Piero, additional, Mercuri, Mario, additional, Bacci, Gaetano, additional, and Ferrari, Sefano, additional

Published
2009
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