Search

Your search keyword '"Babkiewicz, Ewa"' showing total 39 results
Start Over Author "Babkiewicz, Ewa"
39 results on '"Babkiewicz, Ewa"'

7. Enhanced Delivery of Retinoic Acid to Breast Cancer Cells by Folate Receptor-Targeted Folic Acid-Conjugated Glutenin Nanoparticles for Promising Treatment of Breast Cancer

Author

Rajeshkumar, Raja Rajeswari, primary, Pavadai, Parasuraman, additional, Panneerselvam, Theivendren, additional, Pandian, Sureshbabu Ram Kumar, additional, Kumar, A. Santhana Krishna, additional, Maszczyk, Piotr, additional, Babkiewicz, Ewa, additional, Kabilan, Shanmugampillai Jeyarajaguru, additional, and Kunjiappan, Selvaraj, additional

Published
2023
Full Text
View/download PDF

10. Pharmacoinformatics-Based Approach for Uncovering the Quorum-Quenching Activity of Phytocompounds against the Oral Pathogen, Streptococcus mutans

Author

Marimuthu, Shakti Chandra Vadhana, primary, Murugesan, Jayaprabhakaran, additional, Babkiewicz, Ewa, additional, Maszczyk, Piotr, additional, Sankaranarayanan, Murugesan, additional, Thangamariappan, Esakkimuthu, additional, Rosy, Joseph Christina, additional, Ram Kumar Pandian, Sureshbabu, additional, Kunjiappan, Selvaraj, additional, Balakrishnan, Vanavil, additional, and Sundar, Krishnan, additional

Published
2023
Full Text
View/download PDF

12. Temperature and hypoxia‐driven shifts in Daphniainterspecific competition

Author

Maszczyk, Piotr, Krajewski, Karol, Leniowski, Konrad, Pukos, Szymon, Wawrzeńczak, Julia, Wilczynski, Wojciech, Zebrowski, Marcin Lukasz, Lee, Jae‐Seong, and Babkiewicz, Ewa

Abstract

Previous research has shown that elevated temperature and environmental hypoxia are associated with a reduced representation of larger‐bodied species in communities of ectotherms, suggesting their competitive disadvantage resulting from increased oxygen demands and limited oxygen availability. To investigate this, we conducted a comparative analysis of two pairs of competing zooplankton species: Daphnia galeata(smaller‐bodied) and Daphnia pulex(larger‐bodied), as well as D. pulex(smaller‐bodied) and Daphnia magna(larger‐bodied). We monitored their population dynamics under different oxygen concentrations and temperatures, and additionally measured hemoglobin concentration in the latter pair. Contrary to expectations, the results demonstrated that the larger‐bodied species outcompeted the smaller‐bodied ones in all experimental treatments involving the first pair of species. In the second pair, elevated temperature favored the smaller‐bodied species, while environmental hypoxia had the opposite effect. The competitive advantage of D. pulexunder elevated temperature likely stemmed from their ability to allocate energy from somatic growth to reproduction, as indicated by the increased number of reproducing females. Conversely, the competitive advantage of D. magnaunder environmental hypoxia may be attributed to their ability to reallocate energy from reproduction to somatic growth, as indicated by lower reproductive effort and greater plasticity in hemoglobin production. These findings indicate that elevated temperature and hypoxia can independently and jointly influence interspecific competitive abilities by impacting the pace of life. However, the numerical dominance of smaller‐sized species in warm and hypoxic zooplankton communities cannot be explained by their enhanced competitive abilities resulting from a more favorable oxygen supply demand balance.

Published
2024
Full Text
View/download PDF

13. Cytotoxic Potential of Bioactive Compounds from Aspergillus flavus, an Endophytic Fungus Isolated from Cynodon dactylon, against Breast Cancer: Experimental and Computational Approach

Author

Kalimuthu, Arjun Kumar, primary, Pavadai, Parasuraman, additional, Panneerselvam, Theivendren, additional, Babkiewicz, Ewa, additional, Pijanowska, Joanna, additional, Mrówka, Piotr, additional, Rajagopal, Gopalan, additional, Deepak, Venkataraman, additional, Sundar, Krishnan, additional, Maszczyk, Piotr, additional, and Kunjiappan, Selvaraj, additional

Published
2022
Full Text
View/download PDF

14. Cytotoxic Potential of Bioactive Compounds From Aspergillus Flavus, an Endophytic Fungus Isolated From Cynodon dactylon: Experimental and Computational Approach

Author

Kalimuthu, Arjun Kumar, primary, Parasuraman, Pavadai, additional, Panneerselvam, Theivendren, additional, Babkiewicz, Ewa, additional, Pijanowska, Joanna, additional, Mrowka, Piotr, additional, Rajagopal, Gopalan, additional, Venkatraman, Deepak, additional, Sundar, Krishnan, additional, Maszczyk, Piotr, additional, and Kunjiappan, Selvaraj, additional

Published
2022
Full Text
View/download PDF

18. Guanidine–Curcumin Complex-Loaded Amine-Functionalised Hollow Mesoporous Silica Nanoparticles for Breast Cancer Therapy

Author

Viswanathan, Thimma Mohan, primary, Chitradevi, Kaniraja, additional, Zochedh, Azar, additional, Vijayabhaskar, Ramakrishnan, additional, Sukumaran, Sureba, additional, Kunjiappan, Selvaraj, additional, Kumar, Nachimuthu Senthil, additional, Sundar, Krishnan, additional, Babkiewicz, Ewa, additional, Maszczyk, Piotr, additional, and Kathiresan, Thandavarayan, additional

Published
2022
Full Text
View/download PDF

21. Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

Author

Palanichamy, Chandrasekar, primary, Pavadai, Parasuraman, additional, Panneerselvam, Theivendren, additional, Arunachalam, Sankarganesh, additional, Babkiewicz, Ewa, additional, Ram Kumar Pandian, Sureshbabu, additional, Shanmugampillai Jeyarajaguru, Kabilan, additional, Nayak Ammunje, Damodar, additional, Kannan, Suthendran, additional, Chandrasekaran, Jaikanth, additional, Sundar, Krishnan, additional, Maszczyk, Piotr, additional, and Kunjiappan, Selvaraj, additional

Published
2022
Full Text
View/download PDF

23. Combinatorial Delivery of Gallium (III) Nitrate and Curcumin Complex-Loaded Hollow Mesoporous Silica Nanoparticles for Breast Cancer Treatment

Author

Mohan Viswanathan, Thimma, primary, Krishnakumar, Vaithilingam, additional, Senthilkumar, Dharmaraj, additional, Chitradevi, Kaniraja, additional, Vijayabhaskar, Ramakrishnan, additional, Rajesh Kannan, Velu, additional, Senthil Kumar, Nachimuthu, additional, Sundar, Krishnan, additional, Kunjiappan, Selvaraj, additional, Babkiewicz, Ewa, additional, Maszczyk, Piotr, additional, and Kathiresan, Thandavarayan, additional

Published
2022
Full Text
View/download PDF

26. short-term effects of planktivorous fish foraging in the presence of artificial light at night on lake zooplankton.

Author

Tałanda, Joanna, Maszczyk, Piotr, Babkiewicz, Ewa, Rutkowska, Katarzyna, and Ślusarczyk, Mirosław

Subjects
FORAGE fishes, PREDATION, PERCH, ZOOPLANKTON, ECOLOGICAL impact, CALANOIDA, AQUATIC organisms, EUROPEAN perch
Abstract

Numerous studies have revealed that artificial light at night alters the natural patterns of light in space and time and may have various ecological impacts at different ecological levels. However, only a few studies have assessed its effect on interactions between organisms in aquatic environments, including predator–prey interactions in lakes. To fill this gap, we performed a preliminary enclosure experiment in which we compared the foraging effect of juvenile perch (Perca fluviatilis) on a natural lake zooplankton community in the absence and presence of light of high-pressure sodium (HPS) lamps mimicking artificial light emitted by a boat. The results revealed that even short-lasting exposure to HPS lamps may result in increasing fish predation, which in turn decreased the mean body size in zooplankton populations (e.g. Bosmina thersites) and affected the relative proportion between different taxa in zooplankton communities. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

28. Capsaicin-loaded solid lipid nanoparticles: design, biodistribution, in silico modeling and in vitro cytotoxicity evaluation

Author

Kunjiappan, Selvaraj, primary, Sankaranarayanan, Murugesan, additional, Karan Kumar, Banoth, additional, Pavadai, Parasuraman, additional, Babkiewicz, Ewa, additional, Maszczyk, Piotr, additional, Glodkowska-Mrowka, Eliza, additional, Arunachalam, Sankarganesh, additional, Ram Kumar Pandian, Sureshbabu, additional, Ravishankar, Vigneshwaran, additional, Baskararaj, Suraj, additional, Vellaichamy, Sivakumar, additional, Arulmani, Lalitha, additional, and Panneerselvam, Theivendren, additional

Published
2020
Full Text
View/download PDF

30. Design, in silico modelling and functionality theory of folate-receptor-targeted myricetin-loaded bovine serum albumin nanoparticle formulation for cancer treatment

Author

Kunjiappan, Selvaraj, primary, Govindaraj, Saravanan, additional, Parasuraman, Pavadai, additional, Sankaranarayanan, Murugesan, additional, Arunachalam, Sankarganesh, additional, Palanisamy, Ponnusamy, additional, Mohan, Uma Priya, additional, Babkiewicz, Ewa, additional, Maszczyk, Piotr, additional, Vellaisamy, Sivakumar, additional, and Panneerselvam, Theivendren, additional

Published
2020
Full Text
View/download PDF

31. Design, In Silico Modelling, and Functionality Theory of Novel Folate Receptor Targeted Rutin Encapsulated Folic Acid Conjugated Keratin Nanoparticles for Effective Cancer Treatment

Author

Kunjiappan, Selvaraj, primary, Panneerselvam, Theivendren, additional, Govindaraj, Saravanan, additional, Parasuraman, Pavadai, additional, Baskararaj, Suraj, additional, Sankaranarayanan, Murugesan, additional, Arunachalam, Sankarganesh, additional, Babkiewicz, Ewa, additional, Jeyakumar, Aarthi, additional, and Lakshmanan, Muthulakshmi, additional

Published
2020
Full Text
View/download PDF

34. Capsaicin-loaded solid lipid nanoparticles: design, biodistribution, in silico modeling and in vitro cytotoxicity evaluation.

Author

Kunjiappan, Selvaraj, Sankaranarayanan, Murugesan, Kumar, Banoth Karan, Pavadai, Parasuraman, Babkiewicz, Ewa, Maszczyk, Piotr, Glodkowska-Mrowka, Eliza, Arunachalam, Sankarganesh, Pandian, Sureshbabu Ram Kumar, Ravishankar, Vigneshwaran, Baskararaj, Suraj, Vellaichamy, Sivakumar, Arulmani, Lalitha, and Panneerselvam, Theivendren

Subjects
NANOPARTICLES, MITOGEN-activated protein kinases, HEART cells, LIVER cells, STEARIC acid
Abstract

Lower doses of capsaicin (8-methyl-N-vanillyl-6-nonenamide) have the potential to serve as an anticancer drug, however, due to its pungency, irritant effect, poor water solubility and high distribution volume often linked to various off-target effects, its therapeutic use is limited. This study aimed to determine the biodistribution and anticancer efficacy of capsaicin loaded solid lipid nanoparticles (SLNs) in human hepatocellular carcinoma in vitro. In this study, SLNs of stearic acid loaded with capsaicin was formulated by the solvent evaporation-emulsification technique and were instantly characterized for their encapsulation efficiency, morphology, loading capacity, stability, particle size, charge and in vitro drug release profile. Synthesized SLNs were predominantly spherical, 80 nm diameter particles that proved to be biocompatible with good stability in aqueous conditions. In vivo biodistribution studies of the formulated SLNs showed that 48 h after injection in the lateral tail vein, up to 15% of the cells in the liver, 1.04% of the cells in the spleen, 3.05% of the cells in the kidneys, 3.76% of the cells in the heart, 1.31% of the cells in the lungs and 0% of the cells in the brain of rats were determined. Molecular docking studies against the identified targets in HepG2 cells showed that the capsaicin is able to bind Abelson tyrosine-protein kinase, c-Src kinase, p38 MAP kinase and VEGF-receptor. Molecular dynamic simulation showed that capsaicin-VEGF receptor complex is highly stable at 50 nano seconds. The IC50 of capsaicin loaded SLNs in HepG2 cells in vitro was 21.36 μg × ml−1. These findings suggest that capsaicin loaded SLNs are stable in circulation for a period up to 3 d, providing a controlled release of loaded capsaicin and enhanced anticancer activity. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

36. Daphniadepth selection in gradients of light intensity from different artificial sources: An evolutionary trap?

Author

Maszczyk, Piotr, Tałanda, Joanna, Babkiewicz, Ewa, Leniowski, Konrad, and Urban, Paulina

Abstract

It is well known that artificial light at night alters the natural patterns of light in space and time, which interrupts a variety of physiological processes of individuals, altering their life history and behavioral adjustments. However, much less is known about the effect of artificial light at night on their fitness. We tested the hypothesis that planktonic animals, such as Daphniaspp., are able to correctly assess light intensity‐ and spectrum‐dependent‐mortality risk due to predation by planktivorous fish and select depths offering the highest possible fitness gain in the vertical gradient of different artificial light sources (halogen, metal‐halide, cool white LEDs, and high pressure sodium lamps) commonly used in street lighting. To test this hypothesis, we compared the virtual distributions of three clones of Daphnia longispinafrom simulations based on an experimentally parameterized, optimizing individual‐based model with distributions observed in laboratory experiments performed with 5‐d‐old individuals in an experimental apparatus comprised of twin vertical columns. Our hypothesis was confirmed only partially, since the distributions obtained in the experiments overlapped the virtual distributions only in the gradient of LEDs and high pressure sodium light, which suggests that that the strength of the maladaptive response could depend on the type of artificial light (i.e., spectral composition) penetrating the water column. Moreover, the results revealed that the response to the presence of artificial light is clone‐specific, which suggest that it could be a selective factor for microevolutionary changes.

Published
2021
Full Text
View/download PDF

38. Design, In SilicoModelling, and Functionality Theory of Novel Folate Receptor Targeted Rutin Encapsulated Folic Acid Conjugated Keratin Nanoparticles for Effective Cancer Treatment

Author

Kunjiappan, Selvaraj, Panneerselvam, Theivendren, Govindaraj, Saravanan, Parasuraman, Pavadai, Baskararaj, Suraj, Sankaranarayanan, Murugesan, Arunachalam, Sankarganesh, Babkiewicz, Ewa, Jeyakumar, Aarthi, and Lakshmanan, Muthulakshmi

Abstract

Objective: Site-specific and toxic-free drug delivery, is an interesting area of research. Nanoengineered drug delivery systems possess a remarkable potential for effective treatment of various types of cancers. Methods: In this study, novel Folic Acid (FA) conjugated keratin nanoparticles (NPs) were assembled with encapsulation and delivery of Rutin (Rt) into breast cancer cells through the overexpressed folate receptor. The biocompatible, Rt encapsulated FA conjugated keratin NPs (FA@Ker NPs) were successfully formulated by a modified precipitation technique. Their morphological shape and size, size distribution, stability, and physical nature were characterized and confirmed. The drug (Rt) encapsulation efficiency, loading capacity and release kinetics were also studied. Results: The observed results of molecular docking and density functionality theory of active drug (Rt) showed a strong interaction and non-covalent binding of the folate receptor and facilitation of endocytosis in breast cancer cells. Further, in vitro cytotoxic effect of FA@Ker NPs was screened against MCF-7 cancer cells, at 55.2 μg/mL of NPs and found to display 50% of cell death at 24h. Moreover, the NPs enhanced the uptake of Rt in MCF-7 cells, and the apoptotic effect of condensed nuclei and distorted membrane bodies was observed. Also, NPs entered into the mitochondria of MCF-7 cells and significantly increased the level of ROS which led to cell death. Conclusion: The developed FA@Ker NPs might be a promising way to enhance anti-cancer activity without disturbing normal healthy cells.

Published
2019
Full Text
View/download PDF

39. Design, In Silico Modelling, and Functionality Theory of Novel Folate Receptor Targeted Rutin Encapsulated Folic Acid Conjugated Keratin Nanoparticles for Effective Cancer Treatment.

Author

Kunjiappan S, Panneerselvam T, Govindaraj S, Parasuraman P, Baskararaj S, Sankaranarayanan M, Arunachalam S, Babkiewicz E, Jeyakumar A, and Lakshmanan M

Subjects
Antineoplastic Agents administration & dosage, Apoptosis drug effects, Cell Movement drug effects, Cell Survival drug effects, Computer Simulation, Drug Liberation, Humans, MCF-7 Cells, Membrane Potential, Mitochondrial drug effects, Molecular Docking Simulation, Molecular Targeted Therapy, Rutin administration & dosage, Antineoplastic Agents pharmacology, Drug Carriers chemistry, Drug Design, Folate Receptors, GPI-Anchored metabolism, Folic Acid chemistry, Keratins chemistry, Nanoparticles chemistry, Rutin pharmacology
Abstract

Objective: Site-specific and toxic-free drug delivery, is an interesting area of research. Nanoengineered drug delivery systems possess a remarkable potential for effective treatment of various types of cancers., Methods: In this study, novel Folic Acid (FA) conjugated keratin nanoparticles (NPs) were assembled with encapsulation and delivery of Rutin (Rt) into breast cancer cells through the overexpressed folate receptor. The biocompatible, Rt encapsulated FA conjugated keratin NPs (FA@Ker NPs) were successfully formulated by a modified precipitation technique. Their morphological shape and size, size distribution, stability, and physical nature were characterized and confirmed. The drug (Rt) encapsulation efficiency, loading capacity and release kinetics were also studied., Results: The observed results of molecular docking and density functionality theory of active drug (Rt) showed a strong interaction and non-covalent binding of the folate receptor and facilitation of endocytosis in breast cancer cells. Further, in vitro cytotoxic effect of FA@Ker NPs was screened against MCF-7 cancer cells, at 55.2 µg/mL of NPs and found to display 50% of cell death at 24h. Moreover, the NPs enhanced the uptake of Rt in MCF-7 cells, and the apoptotic effect of condensed nuclei and distorted membrane bodies was observed. Also, NPs entered into the mitochondria of MCF-7 cells and significantly increased the level of ROS which led to cell death., Conclusion: The developed FA@Ker NPs might be a promising way to enhance anti-cancer activity without disturbing normal healthy cells., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results