Search

Your search keyword '"Babcock, Lynn"' showing total 180 results
Start Over Author "Babcock, Lynn"
180 results on '"Babcock, Lynn"'

1. Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol.

Author

Tsze, Daniel, Kuppermann, Nathan, Casper, T, Barney, Bradley, Richer, Lawrence, Liberman, Danica, Okada, Pamela, Morris, Claudia, Myers, Sage, Soung, Jane, Mistry, Rakesh, Babcock, Lynn, Spencer, Sandra, Johnson, Michael, Klein, Eileen, Quayle, Kimberly, Steele, Dale, Cruz, Andrea, Rogers, Alexander, Thomas, Danny, Grupp-Phelan, Jacqueline, Johnson, Tiffani, and Dayan, Peter

Subjects
accident & emergency medicine, migraine, paediatric A&E and ambulatory care, Female, Pregnancy, Child, Humans, Prospective Studies, Craniocerebral Trauma, Emergency Service, Hospital, Emergency Treatment, Headache
Abstract

INTRODUCTION: Headache is a common chief complaint of children presenting to emergency departments (EDs). Approximately 0.5%-1% will have emergent intracranial abnormalities (EIAs) such as brain tumours or strokes. However, more than one-third undergo emergent neuroimaging in the ED, resulting in a large number of children unnecessarily exposed to radiation. The overuse of neuroimaging in children with headaches in the ED is driven by clinician concern for life-threatening EIAs and lack of clarity regarding which clinical characteristics accurately identify children with EIAs. The study objective is to derive and internally validate a stratification model that accurately identifies the risk of EIA in children with headaches based on clinically sensible and reliable variables. METHODS AND ANALYSIS: Prospective cohort study of 28 000 children with headaches presenting to any of 18 EDs in the Pediatric Emergency Care Applied Research Network (PECARN). We include children aged 2-17 years with a chief complaint of headache. We exclude children with a clear non-intracranial alternative diagnosis, fever, neuroimaging within previous year, neurological or developmental condition such that patient history or physical examination may be unreliable, Glasgow Coma Scale score

Published
2023

4. Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High‐Dose Intravenous Administration in Young Children With Benzodiazepine‐Refractory Status Epilepticus

Author

Sathe, Abhishek G, Mishra, Usha, Ivaturi, Vijay, Brundage, Richard C, Cloyd, James C, Elm, Jordan J, Chamberlain, James M, Silbergleit, Robert, Kapur, Jaideep, Lowenstein, Daniel H, Shinnar, Shlomo, Cock, Hannah R, Fountain, Nathan B, Babcock, Lynn, and Coles, Lisa D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Brain Disorders, Pediatric, Anticonvulsants, Benzodiazepines, Child, Child, Preschool, Dose-Response Relationship, Drug, Female, Humans, Infusions, Intravenous, Levetiracetam, Male, Phenytoin, Protein Binding, Status Epilepticus, Valproic Acid, central nervous system, clinical pharmacology, clinical trials, emergency medicine, exposure-response, neurology, pharmacokinetics and drug metabolism, pediatrics, protein binding, sparse sampling, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

Fosphenytoin (FOS) and its active form, phenytoin (PHT), levetiracetam (LEV), and valproic acid (VPA) are commonly used second-line treatments of status epilepticus. However, limited information is available regarding LEV and VPA concentrations following high intravenous doses, particularly in young children. The Established Status Epilepticus Treatment Trial, a blinded, comparative effectiveness study of FOS, LEV, and VPA for benzodiazepine-refractory status epilepticus provided an opportunity to investigate early drug concentrations. Patients aged ≥2 years who continued to seizure despite receiving adequate doses of benzodiazepines were randomly assigned to FOS, LEV, or VPA infused over 10 minutes. A sparse blood-sampling approach was used, with up to 2 samples collected per patient within 2 hours following drug administration. The objective of this work was to report early drug exposure of PHT, LEV, and VPA and plasma protein binding of PHT and VPA. Twenty-seven children with median (interquartile range) age of 4 (2.5-6.5) years were enrolled. The total plasma concentrations ranged from 69 to 151.3 μg/mL for LEV, 11.3 to 26.7 μg/mL for PHT and 126 to 223 μg/mL for VPA. Free fraction ranged from 4% to 19% for PHT and 17% to 51% for VPA. This is the first report in young children of LEV concentrations with convulsive status epilepticus as well as VPA concentrations after a 40 mg/kg dose. Several challenges limited patient enrollment and blood sampling. Additional studies with a larger sample size are required to evaluate the exposure-response relationships in this emergent condition.

Published
2021

5. Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus.

Author

Rosenthal, Eric S, Elm, Jordan J, Ingles, James, Rogers, Alexander J, Terndrup, Thomas E, Holsti, Maija, Thomas, Danny G, Babcock, Lynn, Okada, Pamela J, Lipsky, Robert H, Miller, Joseph B, Hickey, Robert W, Barra, Megan E, Bleck, Thomas P, Cloyd, James C, Silbergleit, Robert, Lowenstein, Daniel H, Coles, Lisa D, Kapur, Jaideep, Shinnar, Shlomo, Chamberlain, James M, and Established Status Epilepticus Treatment Trial Study Group

Subjects
Established Status Epilepticus Treatment Trial Study Group, Humans, Nervous System Diseases, Status Epilepticus, Anticonvulsants, Risk Factors, Cohort Studies, Intubation, Intratracheal, Recovery of Function, Adolescent, Adult, Aged, Middle Aged, Child, Female, Male, Young Adult, Brain Disorders, Clinical Research, Neurosciences, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveTo quantify the association between early neurologic recovery, practice pattern variation, and endotracheal intubation during established status epilepticus, we performed a secondary analysis within the cohort of patients enrolled in the Established Status Epilepticus Treatment Trial (ESETT).MethodsWe evaluated factors associated with the endpoint of endotracheal intubation occurring within 120 minutes of ESETT study drug initiation. We defined a blocked, stepwise multivariate regression, examining 4 phases during status epilepticus management: (1) baseline characteristics, (2) acute treatment, (3) 20-minute neurologic recovery, and (4) 60-minute recovery, including seizure cessation and improving responsiveness.ResultsOf 478 patients, 117 (24.5%) were intubated within 120 minutes. Among high-enrolling sites, intubation rates ranged from 4% to 32% at pediatric sites and 19% to 39% at adult sites. Baseline characteristics, including seizure precipitant, benzodiazepine dosing, and admission vital signs, provided limited discrimination for predicting intubation (area under the curve [AUC] 0.63). However, treatment at sites with an intubation rate in the highest (vs lowest) quartile strongly predicted endotracheal intubation independently of other treatment variables (adjusted odds ratio [aOR] 8.12, 95% confidence interval [CI] 3.08-21.4, model AUC 0.70). Site-specific variation was the factor most strongly associated with endotracheal intubation after adjustment for 20-minute (aOR 23.4, 95% CI 6.99-78.3, model AUC 0.88) and 60-minute (aOR 14.7, 95% CI 3.20-67.5, model AUC 0.98) neurologic recovery.ConclusionsEndotracheal intubation after established status epilepticus is strongly associated with site-specific practice pattern variation, independently of baseline characteristics, and early neurologic recovery and should not alone serve as a clinical trial endpoint in established status epilepticus.Trial registration informationClinicalTrials.gov Identifier: NCT01960075.

Published
2021

6. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

Author

Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, Silbergleit, Robert, Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R, Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Kalugdan, Vernon Sayoc, Hemphill, Claude, Madhok, Debbie Yi, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, and Samba, Ima

Subjects
Neurodegenerative, Epilepsy, Clinical Research, Clinical Trials and Supportive Activities, Brain Disorders, Neurosciences, Pediatric, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Anticonvulsants, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Infant, Levetiracetam, Male, Middle Aged, Phenytoin, Status Epilepticus, Valproic Acid, Young Adult, Neurological Emergencies Treatment Trials, Pediatric Emergency Care Applied Research Network investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundBenzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups.MethodsIn this multicentre, double-blind, response-adaptive, randomised controlled trial, we recruited patients from 58 hospital emergency departments across the USA. Patients were eligible for inclusion if they were aged 2 years or older, had been treated for a generalised convulsive seizure of longer than 5 min duration with adequate doses of benzodiazepines, and continued to have persistent or recurrent convulsions in the emergency department for at least 5 min and no more than 30 min after the last dose of benzodiazepine. Patients were randomly assigned in a response-adaptive manner, using Bayesian methods and stratified by age group (65 years), to levetiracetam, fosphenytoin, or valproate. All patients, investigators, study staff, and pharmacists were masked to treatment allocation. The primary outcome was absence of clinically apparent seizures with improved consciousness and without additional antiseizure medication at 1 h from start of drug infusion. The primary safety outcome was life-threatening hypotension or cardiac arrhythmia. The efficacy and safety outcomes were analysed by intention to treat. This study is registered in ClinicalTrials.gov, NCT01960075.FindingsBetween Nov 3, 2015, and Dec 29, 2018, we enrolled 478 patients and 462 unique patients were included: 225 children (aged 65 years). 175 (38%) patients were randomly assigned to levetiracetam, 142 (31%) to fosphenyltoin, and 145 (31%) were to valproate. Baseline characteristics were balanced across treatments within age groups. The primary efficacy outcome was met in those treated with levetiracetam for 52% (95% credible interval 41-62) of children, 44% (33-55) of adults, and 37% (19-59) of older adults; with fosphenytoin in 49% (38-61) of children, 46% (34-59) of adults, and 35% (17-59) of older adults; and with valproate in 52% (41-63) of children, 46% (34-58) of adults, and 47% (25-70) of older adults. No differences were detected in efficacy or primary safety outcome by drug within each age group. With the exception of endotracheal intubation in children, secondary safety outcomes did not significantly differ by drug within each age group.InterpretationChildren, adults, and older adults with established status epilepticus respond similarly to levetiracetam, fosphenytoin, and valproate, with treatment success in approximately half of patients. Any of the three drugs can be considered as a potential first-choice, second-line drug for benzodiazepine-refractory status epilepticus.FundingNational Institute of Neurological Disorders and Stroke, National Institutes of Health.

Published
2020

9. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

Author

Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R., Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Sayoc Kalugdan, Vernon, Hemphill, Claude, Yi Madhok, Debbie, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J. Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, Samba, Ima, Kittick, Marlena, Riviello, Ralph, Massey, John, Bonacquisti, Lisa, Levine, Steven, Motov, Sergey, Fromm, Christian, Hossain, Rukhsana, Likourezos, Antonios, Pushkar, Illya, Terndrup, Thomas, Khaliqdina, Salman, Hill, Michael, Peterson, Bjorn, Terwilliger, Alexia, Holm, Joseph, Wicklund, Kyra, Wewerka, Sandi, Welch, Robert, Pearson, Claire, Kumar, Vijaya Arun, Ayaz, Farhan, Bhuiyan, Saikat, Mika, Valerie H., Morgan, Lola, Jones, Floyd, Dishman, Lorraine, Henry, Thomas, Erickson, Ford, Staugaitis, Abbey, Lawyer, Chloe, Miller, Kathleen, Callaway, Clif, Urban, Alexandra, DiFiore, Sara, Adams, Peter, Baum, Brian, Nomura, Jason, Davis, Barbara, Aufderheide, Tom, Emmrich, Amanda, Mena, Melissa, Labinski, Jacob, Ogedegbe, Chinwe, McCarthy, Diana, Villot-Santiago, Arelis, Goldstein, Joshua, Rosenthal, Eric S., Cohen, Abigail, Mei Su, Chen, Tirrell, Greg, Howell, Melissa, Hendrickson, Marissa, Nerheim, Dan, Jaton, Eric, Biney, Barbara, Gibson, Christopher, Dahlmeier, Erica, Blackburn, Katherine (Lamond), Vaughan-Ogunlusi, Oluwarotimi (Tim), Zehtabchi, Shahriar, Sinert, Richard, Petty, Bryce, Youngquist, Scott, Carlson, Margaret, Gilles, Nadege, Weingast, Sarah (Zelonis), Stern, Barney, Hopp, Jennifer, Ganley, Virginia, Ornato, Joseph, Hogan, Christopher, Payne, Alan, Shreve, Kate, Dayan, Peter, Kuppermann, Nathan, Denninghoff, Kurt, Stanley, Rachel, Ruddy, Richard, Lerner, E. Brooke, Dean, J. Michael, Casper, Charles, Nigrovic, Lise, Schalick, Walt, Nelson, Doug, Thomas, Bobbe, Okada, Pamela, Lee, Amanda, Truesdale, Natasha, Chan, Steven, Naresh, Mhadhumithaa, Robinson, Venita, Hwang, Jieun, Carlston, Kristi, Dela Cruz, Michael, Harbour, Toni, Karki, Reena, Cohen, Daniel M., Nowakowski, Amy, Lin, Cindy, Fisher Kenny, Erin, Steele, Dale, Merck, Lisa H., Ryan, Erin, Basso, Kristin, D'Urso, Lesley (Wasilewski), Brown, Kathleen, Nauman, Gina, Ledda, Matthew, Gillen, Sean, Grant, Vanessa, Vance, Cheryl, Nishijima, Daniel K., Pimenta, Kyle, Herzog, Noelle, Bennett, Jonathan, Eisenhart, Christine, Thomas, Danny, Wagner, Duke, Hickey, Robert W., Azrak, Rose, Rubalcava, Daniel, Mondragon, Juan, Gonzalez, Victor, Khalil, Maha, Hart, Kristina, Parker, Sara, Lumba-Brown, Angela, Quayle, Kim, Chinta, Sri, Robinson, Debra, Kwok, Maria, Peery, Brooke, Ochs, Julie, Suarez, Leonor, Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, and Silbergleit, Robert

Published
2020
Full Text
View/download PDF

13. Agreement of electronic health record–documented race and ethnicity with parental report.

Author

Goyal, Monika, Alpern, Elizabeth R., Webb, Michael, Brousseau, David C., Chamberlain, James M., Zorc, Joseph J., Frey, Theresa, Wiersma, Alexandria, Barney, Bradley J., Drendel, Amy L., Babcock, Lynn, Leonard, Julie, Wiersma, Alexandria J., Ahamed, Sheikh, Nielsen, Blake E., Alpern, Elizabeth, Bajaj, Lalit, Brousseau, David, Chamberlain, Jim, and Grundmeier, Bob

Subjects
DOCUMENTATION standards, HEALTH services accessibility, MEDICAL quality control, MULTIPLE regression analysis, HOSPITAL emergency services, PARENT attitudes, DESCRIPTIVE statistics, MULTIVARIATE analysis, PEDIATRICS, RACISM, LONGITUDINAL method, ELECTRONIC health records, ACQUISITION of data, RESEARCH, STATISTICS, MINORITIES, TEXT messages, CONFIDENCE intervals, HEALTH equity, QUALITY assurance
Abstract

The article explores the agreement between electronic health record (EHR)-documented and parent-reported race and ethnicity in pediatric emergency care settings. It discusses significant overall agreement but notes discrepancies, particularly for less-represented racial and ethnic groups, suggesting the need for improved methods to enhance data accuracy and equity in healthcare research and provision.

Published
2024
Full Text
View/download PDF

15. Describing pediatric acute kidney injury in children admitted from the emergency department

Author

Hanson, Holly R., Babcock, Lynn, Byczkowski, Terri, and Goldstein, Stuart L.

Subjects
Diagnosis, Research, Risk factors, Acute kidney failure -- Diagnosis -- Risk factors, Medical research, Pediatric emergencies -- Research
Abstract

Author(s): Holly R. Hanson [sup.1] , Lynn Babcock [sup.1] , Terri Byczkowski [sup.1] , Stuart L. Goldstein [sup.2] Author Affiliations: (Aff1) 0000 0000 9025 8099, grid.239573.9, Division of Emergency Medicine, [...], Objective To define those children who develop acute kidney injury (AKI) within 48 h of admission from the emergency department (ED) and ascertain patient-related factors in the ED associated with AKI. Methods Retrospective, cohort study of children, birth to 19 years, admitted to a tertiary pediatric hospital from the ED between January 2010 and December 2013 who had serum creatinine (SCr) drawn as part of clinical care. AKI was defined as a 50% increase in SCr above baseline, as measured within 48 h of hospital presentation. Multivariable logistic regression was performed to determine factors associated with AKI by comparing those with and without kidney injury on hospital presentation. Results Of all ED admissions, 13,827 subjects (27%) were included; 10% developed AKI. Of kids with AKI, 75% had a measured SCr consistent with AKI while in the ED, 36% were admitted to the intensive care unit, and 2% died (all significantly more than children without AKI). Young age, history of AKI or solid organ transplant, receipt of intravenous fluids or central venous access in the ED, and admission to intensive care were factors independently associated with AKI (AUC = 0.793, 95% CI 0.78-0.81). Conclusions One in 10 children who had SCr measured and were admitted to a tertiary pediatric hospital had AKI on or within 48 h of presentation. Inherent characteristics, identifiable in the ED, are associated with an increased risk of AKI. Future research should focus on improving AKI recognition in the ED by the development of a risk stratification tool.

Published
2018
Full Text
View/download PDF

17. Psychosocial Care for Injured Children: Worldwide Survey among Hospital Emergency Department Staff

Author

Osmond, Martin, Plint, Amy, Freedman, Stephen, Johnson, David, Murray, Diana, Williamson-Urquhart, Sarah, Curran, Janet, Dixon, Andrew, Meckler, Garth, Bialy, Liza, Doan, Quynh, Stang, Antonia, Mater, Ahmed, Beer, Darcy, Joubert, Gary, Crocco, Anthony, Davis, Adrienne, Moore, Andrea, Alqurashi, Waleed, Dubrovsky, Sasha, Trottier, Evelyne, Blanchet, Mathieu, Hurley, Katrina, Porter, Robert, Auerbach, Marc, Chang, Todd, Cruz, Andrea, Macias, Charles G., Florin, Todd A., Kharbanda, Anupam B., Mahajan, Prashant, Mistry, Rakesh, Schnadower, David, Stanley, Rachel, Nigrovic, Lise, Michelson, Kenneth, Zorc, Joe, Lyttle, Mark, Maconochie, Ian, Hartshorn, Stuart, Foster, Steven, Bevan, Cath, O'Sullivan, Ronan, Mitchelson, Mark, Maney, Julie-Ann, Potter, Sarah, Younge, Paul, Powell, Colin V.E., Robinson, Gisela, Blackburn, Carol, Bolger, Turlough, McNamara, Roisin, Leonard, Paul, Reuben, Adam, Choudhery, Vince, Mulligan, Joanne, Alcock, Roger, Davies, Ffion, Mehta, Bimal, Parikh, Ami, Ross, James, Criddle, John, Sutherland, Emer, Sajjanhar, Tina, Wong, Shye, Thiagarajan, Jai, Rowland, Andrew, Potier, Katherine, Dieppe, Clare, Thomas, Lucy, Smith, Jason, Vorwerk, Chris, Lenton, Kate, Burke, Derek, Barling, Jason, Mullen, Niall, Dickson-Jardine, Kirsty, Mintegui Raso, Santiago, Gómez, Borja, Da Dalt, Liviana, Gervaix, Alain, Moll, Henriette, Waisman, Yehezkel, Parri, Niccolò, Titomanlio, Luigi, Benito, Javier, Yilmaz, Hayri Levent, Teksam, Ozlem, Srivastava, Geetanjali, Bognar, Zsolt, Moldovan, Diana, Luaces-Cubells, Carles, Qureshi, Nadeem, Cheron, Gerard, Kreier, Felix, Velasco, Roberto, Leroy, Sandrine, Simon, Gabor, Van de Voorde, Patrick, Mintegi, Santiago, Ruddy, Richard, Dayan, Peter, Hickey, Robert, Kuppermann, Nathan, Chamberlain, James, Dean, J. Michael, Lerner, E. Brooke, Rogers, Alexander, Cohen, Daniel, Babcock, Lynn, Brousseau, David, Kwok, Maria, Macias, Charles, Bajaj, Lalit, Chun, Thomas, Bennett, Jonathan, Tzimenatos, Leah, Nelson, Douglas, Brown, Kathy, Powell, Elizabeth, Cheng, Nicholas, Zhang, Michael, Craig, Simon, Babl, Franz E., Dalziel, Stuart, Sinn, Kam, McCaskill, Mary, George, Shane, Jocelyn Neutze, Phillips, Natalie, Borland, Meredith, Barrow, Lisa, Rao, Arjun, Furyk, Jeremy, Kochar, Amit, Chamberlain, Jim, Kharbanda, Anupam, Babl, Franz, Alisic, Eva, Hoysted, Claire, Kassam-Adams, Nancy, Landolt, Markus A., Curtis, Sarah, and Lyttle, Mark D.

Published
2016
Full Text
View/download PDF

22. Challenges Enrolling Children Into Traumatic Brain Injury Trials: An Observational Study

Author

Stanley, Rachel M., Johnson, Michael D., Vance, Cheryl, Bajaj, Lalit, Babcock, Lynn, Atabaki, Shireen, Thomas, Danny, Simon, Harold K., Cohen, Daniel M., Rubacalva, Daniel, David Adelson, P., Bulloch, Blake, Rogers, Alexander J., Mahajan, Prashant, Baren, Jill, Lee, Lois, Hoyle, John, Quayle, Kimberly, Charles Casper, T., Michael Dean, J., and Kuppermann, Nathan

Published
2017
Full Text
View/download PDF

24. Updated Diagnosis Grouping System for Pediatric Emergency Department Visits.

Author

Fant, Colleen, Marin, Jennifer R., Ramgopal, Sriram, Simon, Norma-Jean E., Richards, Rachel, Olsen, Cody S., Alessandrini, Evaline A., Alpern, Elizabeth R., Babcock, Lynn, Bajaj, Lalit, Brousseau, David, Campos, Diego A., Chamberlain, James M., Cook, Larry, Deakyne Davies, Sara J., Elsholz, Cara, Gorelick, Marc H., Grundmeier, Robert W., Mahajan, Prashant, and Shihabuddin, Bashar

Published
2023
Full Text
View/download PDF

25. Findings from a Randomized Controlled Trial of SMART: An EHealth Intervention for Mild Traumatic Brain Injury.

Author

Wade, Shari L, Sidol, Craig, Babcock, Lynn, Schmidt, Matthew, Kurowski, Brad, Cassedy, Amy, and Zhang, Nanhua

Subjects
BRAIN injuries, RANDOMIZED controlled trials, HEALTH behavior, PSYCHOLOGICAL resilience
Abstract

Objective The aim of this study was to examine the efficacy of the SMART (Self-Management After Recent Traumatic brain injury) program and potential moderators. Methods Parallel randomized controlled trial (ClinicalTrials.gov Identifier: NCT03498495) was conducted. Eligibility criteria included treatment for mild traumatic brain injury in the emergency department and age 11–18 years. Participants were assigned equally to SMART (n  = 35) or usual care (UC; n  = 36). SMART included symptom monitoring and online modules supporting the return to activities and symptom management. Coping and quality of life (QoL) (primary outcomes) and post-concussive symptoms (secondary outcome) were assessed at baseline and weekly for 4 weeks. Results Groups did not differ in coping, QoL, or return to pre-injury symptom levels at any time point. Problem-focused engagement (PFE) moderated group differences over time (p  = .02). At high PFE, UC participants reported lower QoL at time 1 (effect size [ES] = 0.60); SMART participants did not report a decline at any point. At low PFE, SMART participants reported declining QoL from pre-injury to time 1 (ES = 0.68), whereas UC participants reported an increase from time 1 to 3 (ES = 0.56). PFE also moderated group differences on the Health and Behavior Inventory (HBI) cognitive (p  = .02) and somatic symptom scales (p  = .05). At high PFE, SMART participants reported a more rapid return to pre-injury levels than UC participants (p  = .05). Resilience also moderated group differences in QoL and HBI cognitive recovery. Conclusion Effectiveness of the SMART app varied based on preinjury coping styles and resilience, underscoring the potential need to tailor treatments to individual characteristics. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. Computed Tomography With Intravenous Contrast Alone: The Role of Intra-abdominal Fat on the Ability to Visualize the Normal Appendix in Children

Author

Garcia, Madelyn, Taylor, George, Babcock, Lynn, Dillman, Jonathan R., Iqbal, Vaseem, Quijano, Carla V., Wootton-Gorges, Sandra L., Adelgais, Kathleen, Anupindi, Sudha A., Sonavane, Sushil, Joshi, Aparna, Veeramani, Murugusundaram, Atabaki, Shireen M., Monroe, David J., Blumberg, Stephen J., Ruzal-Shapiro, Carrie, Cook, Lawrence J., Dayan, Peter S., and Courtney, Mark D.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results