27 results on '"Babatunde Salako"'
Search Results
2. Machine Learning–Based Hyperglycemia Prediction: Enhancing Risk Assessment in a Cohort of Undiagnosed Individuals
- Author
-
Kolapo Oyebola, Funmilayo Ligali, Afolabi Owoloye, Blessing Erinwusi, Yetunde Alo, Adesola Z Musa, Oluwagbemiga Aina, and Babatunde Salako
- Subjects
Medicine - Abstract
Abstract BackgroundNoncommunicable diseases continue to pose a substantial health challenge globally, with hyperglycemia serving as a prominent indicator of diabetes. ObjectiveThis study employed machine learning algorithms to predict hyperglycemia in a cohort of individuals who were asymptomatic and unraveled crucial predictors contributing to early risk identification. MethodsThis dataset included an extensive array of clinical and demographic data obtained from 195 adults who were asymptomatic and residing in a suburban community in Nigeria. The study conducted a thorough comparison of multiple machine learning algorithms to ascertain the most effective model for predicting hyperglycemia. Moreover, we explored feature importance to pinpoint correlates of high blood glucose levels within the cohort. ResultsElevated blood pressure and prehypertension were recorded in 8 (4.1%) and 18 (9.2%) of the 195 participants, respectively. A total of 41 (21%) participants presented with hypertension, of which 34 (83%) were female. However, sex adjustment showed that 34 of 118 (28.8%) female participants and 7 of 77 (9%) male participants had hypertension. Age-based analysis revealed an inverse relationship between normotension and age (rPrPF1 ConclusionsThe random forest classifier identified significant clinical correlates associated with hyperglycemia, offering valuable insights for the early detection of diabetes and informing the design and deployment of therapeutic interventions. However, to achieve a more comprehensive understanding of each feature’s contribution to blood glucose levels, modeling additional relevant clinical features in larger datasets could be beneficial.
- Published
- 2024
- Full Text
- View/download PDF
3. Spatial distribution and ecological niche modeling of geographical spread of Anopheles gambiae complex in Nigeria using real time data
- Author
-
Adedapo Adeogun, Ayodele Samuel Babalola, Okefu Oyale Okoko, Tolulope Oyeniyi, Ahmed Omotayo, Romoke Tawakalitu Izekor, Oluwakemi Adetunji, Abiodun Olakiigbe, Olalekan Olagundoye, Monsuru Adeleke, Cynthia Ojianwuna, Dagona Adamu, Abdullahi Daskum, Jibrin Musa, Obadiah Sambo, Oduola Adedayo, Petrus Uchenna Inyama, Lazarus Samdi, Abiodun Obembe, Musa Dogara, Poloma Kennedy, Suleiman Mohammed, Rebecca Samuel, Chioma Amajoh, Musa Adesola, Mohammed Bala, Mary Esema, Mamudu Omo-Eboh, Marianne Sinka, Olufunmilayo Ajoke Idowu, Adeolu Ande, Israel Olayemi, Abdulsalami Yayo, Perpetua Uhomoibhi, Samson Awolola, and Babatunde Salako
- Subjects
Medicine ,Science - Abstract
Abstract The need for evidence-based data, to inform policy decisions on malaria vector control interventions in Nigeria, necessitated the establishment of mosquito surveillance sites in a few States in Nigeria. In order to make evidence-based-decisions, predictive studies using available data becomes imperative. We therefore predict the distribution of the major members of the Anopheles gambiae s.l. in Nigeria. Immature stages of Anopheles were collected from 72 study locations which span throughout the year 2020 resulted in the identification of over 60,000 Anopheline mosquitoes. Of these, 716 breeding sites were identified with the presence of one or more vector species from the An. gambiae complex and were subsequently used for modelling the potential geographical distribution of these important malaria vectors. Maximum Entropy (MaxEnt) distribution modeling was used to predict their potentially suitable vector habitats across Nigeria. A total of 23 environmental variables (19 bioclimatic and four topographic) were used in the model resulting in maps of the potential geographical distribution of three dominant vector species under current climatic conditions. Members of the An. gambiae complex dominated the collections (98%) with Anopheles stephensi, Anopheles coustani, Anopheles funestus, Anopheles moucheti, Anopheles nilli also present. An almost equal distribution of the two efficient vectors of malaria, An. gambiae and Anopheles coluzzii, were observed across the 12 states included in the survey. Anopheles gambiae and Anopheles coluzzii had almost equal, well distributed habitat suitability patterns with the latter having a slight range expansion. However, the central part of Nigeria (Abuja) and some highly elevated areas (Jos) in the savannah appear not suitable for the proliferation of these species. The most suitable habitat for Anopheles arabiensis was mainly in the South-west and North-east. The results of this study provide a baseline allowing decision makers to monitor the distribution of these species and establish a management plan for future national mosquito surveillance and control programs in Nigeria.
- Published
- 2023
- Full Text
- View/download PDF
4. Performance evaluation of SARS-CoV-2 rapid diagnostic tests in Nigeria: A cross-sectional study.
- Author
-
Akhere A Omonkhua, Adedayo Faneye, Kazeem S Akinwande, Okpokoro Evaezi, Nathan Y Shehu, Adedeji Onayade, Chinwe Lucia Ochu, Mustapha Popoola, Nnadi Emmanuel, Temitope Ojo, Cornelius Ohonsi, Abdullahi Abubakar, Elizabeth Odeh, Paul Akinduti, Onikepe Folarin, John Samson Bimba, Ehimario Igumbor, Kelly Elimian, Victory Fabian Edem, Luka Pam D, Tunde Olusola, Loretta Ntoimo, Michael Olugbile, Adewale Victor Opayele, Ibrahim Kida, Shwe David, Augustine Onyeaghala, Isaac Igbarumah, Omosivie Maduka, Magaji A Mahmoud, Abdul Rahman El-Fulatty, David O Olaleye, Omale Simon, Iriagbonse Iyabo Osaigbovo, Darlington Ewaen Obaseki, Afolaranmi Tolulupe, Christian Happi, Yusuf Bara Jibrin, Friday Okonofua, Timan Eliya, Gomerep Simji, Izang Joy Abi, Emmanuel Ameh, Ibrahim Mahmood Maigari, Sulaiman Alhaji, Ifedayo Adetifa, Babatunde Salako, Suleiman Bogoro, Chikwe Ihekweazu, Georgina N Odaibo, and COVID-19 RDT Validation in Nigeria (CORVAN) study group
- Subjects
Public aspects of medicine ,RA1-1270 - Abstract
The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria. This has greatly improved test turnover rates and significantly decreased the high technical demands of RT-PCR. However, there is currently no nationally representative evaluation of the performance characteristics and reliability of these kits. This study assessed the sensitivity, specificity, and predictive values of ten RDT kits used for COVID-19 testing in Nigeria. This large multi-centred cross-sectional study was conducted across the 6 geo-political zones of Nigeria over four months. Ten antigen (Ag) and antibody (Ab) RDT kits were evaluated, and the results were compared with RT-PCR. One thousand, three hundred and ten (1,310) consenting adults comprising 767 (58.5%) males and 543 (41.5%) females participated in the study. The highest proportion, 757 (57.7%), were in the 20-39 years' age group. In terms of diagnostic performance, Lumira Dx (61.4, 95% CI: 52.4-69.9) had the highest sensitivity while MP SARS and Panbio (98.5, 95% CI: 96.6-99.5) had the highest specificity. For predictive values, Panbio (90.7, 95% CI: 79.7-96.9) and Lumira Dx (81.2, 95% CI: 75.9-85.7) recorded the highest PPV and NPV respectively. Ag-RDTs had better performance characteristics compared with Ab-RDTs; however, the sensitivities of all RDTs in this study were generally low. The relatively high specificity of Ag-RDTs makes them useful for the diagnosis of infection in COVID-19 suspected cases where positive RDT may not require confirmation by molecular testing. There is therefore the need to develop RDTs in-country that will take into consideration the unique environmental factors, interactions with other infectious agents, and strains of the virus circulating locally. This may enhance the precision of rapid and accurate diagnosis of COVID-19 in Nigeria.
- Published
- 2024
- Full Text
- View/download PDF
5. The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
- Author
-
Olufemi Samuel Amoo, Funmi Adewara, Bosun Tijani, Tochukwu Ifeanyi Onuigbo, Amaka Stephanie Ikemefuna, Joy Isioma Oraegbu, Tazeen Rizvi, Azuka Okwuraiwe, Chika Onwuamah, Joseph Shaibu, Ayorinde James, Greg Ohihoin, Fehintola Ige, Dorcas Kareithi, Agatha David, Steven Karera, Hammed Agboola, Anthony Adeniyi, Josephine Obi, Dominic Achanya, Ebenezer Odewale, Osaga Oforomeh, Gideon Liboro, Olayemi Nwogbe, Oliver Ezechi, Richard Adegbola, Rosemary Audu, and Babatunde Salako
- Subjects
Medicine ,Science - Abstract
The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country. Since then, there has been steady increase in the number of cases. However, the number of cases in Nigeria is low in comparison to cases reported by other countries with similar large populations, despite the poor health system prevailing in the country. This has been mainly attributed to the low testing capacity in Nigeria among other factors. Therefore, there is a need for innovative ways to increase the number of persons testing for COVID-19. The aim of the study was to pilot a nasopharyngeal swab self-sample collection model that would help increase COVID-19 testing while ensuring minimal person-to-person contact being experienced at the testing center. 216 participants took part in this study which was carried out at the Nigerian Institute of Medical Research between June and July 2020. Amongst the 216 participants, 174 tested negatives for both self-collected samples and samples collected by Professionals, 30 tested positive for both arms, with discrepancies occurring in 6 samples where the self-collected samples were positive while the ones collected by the professionals were negative. The same occurred in another set of 6 samples with the self-collected samples being negative and the professional—collected sample coming out positive, with a sensitivity of 83.3% and a specificity of 96.7%. The results of the interrater analysis are Kappa = 0.800 (95% CI, 0.690 to 0.910) which implies an outstanding agreement between the two COVID-19 sampling methods. Furthermore, since p< 0.001 Kappa (k) coefficient is statistically different from zero, our findings have shown that self-collected samples can be reliable in the diagnosis of COVID-19.
- Published
- 2021
6. Prevalence and Presentation of Paediatric Coronavirus Disease 2019 in Lagos, Nigeria
- Author
-
Abideen Salako, Oluwatosin Odubela, Tomilola Musari-Martins, Priscilla Ezemelue, Titilola Gbaja-Biamila, Babasola Opaneye, Ayorinde James, Osaga Oforomeh, Kazeem Osuolale, Adesola Musa, Emelda Chukwu, Nurudeen Rahman, Agatha David, Rosemary Audu, Oliver Ezechi, and Babatunde Salako
- Subjects
Pediatrics ,RJ1-570 - Abstract
Background. The objective of this study was to describe the prevalence and clinical features of coronavirus disease 2019 (COVID-19) among children (≤18 years) evaluated for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection at a testing centre in Lagos, Nigeria. Methodology. This was a retrospective study. Data on the sociodemographic, clinical characteristics and SARS-CoV-2 results of participants at a modified drive-through centre for COVID-19 test sample collection over four months were retrieved from the electronic medical records (EMR). Data obtained were analyzed using SPSS version 22.0. Results. A total of 307 children (≤18 years) were evaluated in this review. The prevalence of SARS-CoV-2 infection among the paediatric population was 16.3%. The median age (interquartile range (IQR)) was 9 (4–14) years. Common symptoms reported by the positive cases were fever (40.0%), cough (32.9%), sore throat (17.1%), and runny nose (15.7%). The majority of the positive cases had mild symptoms. Fever and sore throat were associated with the positive cases. Conclusion. Fever and sore throat were associated with SARS-CoV-2 infection among our cohort which buttresses the need for a high level of suspicion and clinical acumen in the management of common febrile diseases in paediatric settings.
- Published
- 2021
- Full Text
- View/download PDF
7. Capabilities, opportunities and motivations for integrating evidence-based strategy for hypertension control into HIV clinics in Southwest Nigeria.
- Author
-
Juliet Iwelunmor, Oliver Ezechi, Chisom Obiezu-Umeh, Titilola Gbajabiamila, Adesola Z Musa, David Oladele, Ifeoma Idigbe, Aigbe Ohihoin, Joyce Gyamfi, Angela Aifah, Babatunde Salako, and Olugbenga Ogedegbe
- Subjects
Medicine ,Science - Abstract
BackgroundGiven the growing burden of cardiovascular diseases in sub-Saharan Africa, global donors and governments are exploring strategies for integrating evidence-based cardiovascular diseases prevention into HIV clinics. We assessed the capabilities, motivations and opportunities that exist for HIV clinics to apply evidence-based strategies for hypertension control among people living with HIV (PLHIV) in Nigeria.MethodsWe used a concurrent Quan-Qual- study approach (a quantitative first step using structured questionnaires followed by a qualitative approach using stakeholder meetings).We invited key stakeholders and representatives of HIV and non-communicable disease organizations in Lagos, Nigeria to 1) assess the capacity of HIV clinics (n = 29) to, and; 2) explore their attitudes and perceptions towards implementing evidence-based strategies for hypertension management in Lagos, Nigeria (n = 19)The quantitative data were analyzed using SPSS whereas responses from the stakeholders meeting were coded and analyzed using thematic approach and an implementation science framework, the COM-B (Capabilities, Opportunities, Motivations and Behavior) model, guided the mapping and interpretation of the data.ResultsOut of the 29 HIV clinics that participated in the study, 28 clinics were public, government-owned facilities with 394 HIV patients per month with varying capabilities, opportunities and motivations for integrating evidence-based hypertension interventions within their services for PLHIV. Majority of the clinics (n = 26) rated medium-to-low on the psychological capability domains, while most of the clinics (n = 25) rated low on the physical capabilities of integrating evidence-based hypertension interventions within HIV clinics. There was high variability in the ratings for the opportunity domains, with physical opportunities rated high in only eight HIV clinics, two clinics with a medium rating and nineteen clinics with a low rating. Social opportunity domain tended to be rated low in majority of the HIV clinics (n = 21). Lastly, almost all the HIV clinics (n = 23) rated high on the reflective motivation domain although automatic motivations tended to be rated low across the HIV clinics.ConclusionIn this study, we found that with the exception of motivations, the relative capabilities whether physical or psychological and the relative opportunities for integrating evidence-based hypertension intervention within HIV clinics in Nigeria were minimal. Thus, there is need to strengthen the HIV clinics in Lagos for the implementation of evidence-based hypertension interventions within HIV clinics to improve patient outcomes and service delivery in Southwest Nigeria.
- Published
- 2019
- Full Text
- View/download PDF
8. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
- Author
-
Maggie C Y Ng, Mariaelisa Graff, Yingchang Lu, Anne E Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R Yanek, Mary F Feitosa, Mary K Wojczynski, Kristin Rand, Jennifer A Brody, Brian E Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A Lange, Michael A Nalls, Hayrettin Okut, Salman M Tajuddin, Bamidele O Tayo, Sailaja Vedantam, Jonathan P Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R Irvin, Badri Padhukasahasram, Jennifer A Smith, Wei Zheng, Matthew A Allison, Christine B Ambrosone, Elisa V Bandera, Traci M Bartz, Sonja I Berndt, Leslie Bernstein, William J Blot, Erwin P Bottinger, John Carpten, Stephen J Chanock, Yii-Der Ida Chen, David V Conti, Richard S Cooper, Myriam Fornage, Barry I Freedman, Melissa Garcia, Phyllis J Goodman, Yu-Han H Hsu, Jennifer Hu, Chad D Huff, Sue A Ingles, Esther M John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F Press, Rebecca Rohde, Benjamin A Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S Siscovick, Janet L Stanford, Victoria L Stevens, Alex Stram, Sara S Strom, Dhananjay Vaidya, John S Witte, Jie Yao, Xiaofeng Zhu, Regina G Ziegler, Alan B Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D Faul, Hakon Hakonarson, Albert M Levin, Katherine L Nathanson, Erin B Ware, David R Weir, Wei Zhao, Degui Zhi, Bone Mineral Density in Childhood Study (BMDCS) Group, Donna K Arnett, Struan F A Grant, Sharon L R Kardia, Olufunmilayo I Oloapde, D C Rao, Charles N Rotimi, Michele M Sale, L Keoki Williams, Babette S Zemel, Diane M Becker, Ingrid B Borecki, Michele K Evans, Tamara B Harris, Joel N Hirschhorn, Yun Li, Sanjay R Patel, Bruce M Psaty, Jerome I Rotter, James G Wilson, Donald W Bowden, L Adrienne Cupples, Christopher A Haiman, Ruth J F Loos, and Kari E North
- Subjects
Genetics ,QH426-470 - Abstract
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ancestry genomes. We performed large scale meta-analyses and replications in up to 52,895 individuals for BMI and up to 23,095 individuals for WHRadjBMI from the African Ancestry Anthropometry Genetics Consortium (AAAGC) using 1000 Genomes phase 1 imputed GWAS to improve coverage of both common and low frequency variants in the low linkage disequilibrium African ancestry genomes. In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P < 5×10-8: seven for BMI, and one for WHRadjBMI in African ancestry individuals. An additional novel locus (SPRYD7/DLEU2) was identified for WHRadjBMI when combined with European GWAS. In the sex-stratified analyses, we identified three novel loci for BMI (INTS10/LPL and MLC1 in men, IRX4/IRX2 in women) and four for WHRadjBMI (SSX2IP, CASC8, PDE3B and ZDHHC1/HSD11B2 in women) in individuals of African ancestry or both African and European ancestry. For four of the novel variants, the minor allele frequency was low (
- Published
- 2017
- Full Text
- View/download PDF
9. Skin changes in patients with chronic renal failure
- Author
-
Olarenwaju Falodun, Adebola Ogunbiyi, Babatunde Salako, and Ade Kunle George
- Subjects
Medicine - Abstract
Management of patients with renal failure remains a major problem in poor-resource nations. Cutaneous manifestations in this group of patients are varied and remain helpful in differentiating acute from chronic renal failure (CRF). We studied the prevalence and pattern of skin disorders in patients with CRF at The University College Hospital, Ibadan, Nigeria, during the period between May 2006 and February 2007. Relevant information was collected with the aid of a questionnaire. The patients were then examined for skin disorders. One hundred and twenty patients who met the inclusion criteria were recruited into the study. The mean age of the CRF patients was 43.12 ± 15.38 years, while that of the control subjects was 43.13 ± 15.38 years. Seventy-six of the 120 patients (63.3%) were on chronic hemodialysis while 44 (36.5%) were on conservative management. A total of 107 patients (89.1%) had at least one skin problem. The skin disorders seen include xerosis in 72 (60%), pruritus in 32 (26.7%), hyper-pigmentation, icthyosis and pityriasis versicolor in nine patients each (7.5%), either singly or in combination. Pallor of the skin was seen in three of the patients (2.5%), while uremic frost was seen in one (0.8%). Nail changes were seen in 48 patients (40%). We conclude that xerosis, pruritus, pigmentary and nail changes were the most common skin disorders in patients with CRF in our environment.
- Published
- 2011
10. Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis.
- Author
-
Nicholas P Reder, Bamidele O Tayo, Babatunde Salako, Adesola Ogunniyi, Adebowale Adeyemo, Charles Rotimi, and Richard S Cooper
- Subjects
Medicine ,Science - Abstract
The pathway-focused association approach offers a hypothesis driven alternative to the agnostic genome-wide association study. Here we apply the pathway-focused approach to an association study of hypertension, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in 1614 Nigerians with genome-wide data.Testing of 28 pathways with biological relevance to hypertension, selected a priori, containing a total of 101 unique genes and 4,349 unique single-nucleotide polymorphisms (SNPs) showed an association for the adrenergic alpha 1 (ADRA1) receptor pathway with hypertension (pp>10(-5)) SNPs offers a novel method for detecting the "missing heritability" of hypertension. These findings warrant further studies in similar and other populations to assess the generalizability of our results, and illustrate the potential of the pathway-focused approach to investigate genetic variation in hypertension.
- Published
- 2012
- Full Text
- View/download PDF
11. Association between Urinary N-Acetyl-Beta-D-Glucosaminidase and Microalbuminuria in Diabetic Black Africans
- Author
-
Francis Patrick Udomah, Udeme Ekpenyong Ekrikpo, Emmanuel Effa, Babatunde Salako, Ayodeji Arije, and Solomon Kadiri
- Subjects
Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Diabetes mellitus is the commonest cause of ESRD worldwide and third most common cause in Nigeria. Recent reports from Nigeria indicate the prevalence of diabetic nephropathy as an aetiology of ESRD is increasing necessitating early diagnosis of diabetic nephropathy. We measured the urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), NAG/creatinine ratio, urinary protein-creatinine ratio and calculated eGFR in 30 recently diagnosed nonhypertensive diabetics and 67 controls. The age and sex distribution, systolic blood pressure, serum and urinary creatinine were similar for both groups. There was higher urinary excretion of NAG (304 versus 184 μmol/h/L, 𝑃
- Published
- 2012
- Full Text
- View/download PDF
12. Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry.
- Author
-
Amidou N'Diaye, Gary K. Chen, Cameron D. Palmer, Bing Ge, Bamidele Tayo, Rasika A. Mathias, Jingzhong Ding, Michael A. Nalls, Adebowale Adeyemo, Véronique Adoue, Christine B. Ambrosone, Larry Atwood, Elisa V. Bandera, Lewis C. Becker, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Eric Boerwinkle, Angela Britton, Graham Casey, Stephen J. Chanock, Ellen Demerath, Sandra L. Deming, W. Ryan Diver, Caroline Fox, Tamara B. Harris, Dena G. Hernandez, Jennifer J. Hu, Sue A. Ingles, Esther M. John, Craig Johnson, Brendan Keating, Rick A. Kittles, Laurence N. Kolonel, Stephen B. Kritchevsky, Loic Le Marchand, Kurt Lohman, Jiankang Liu, Robert C. Millikan, Adam Murphy, Solomon Musani, Christine Neslund-Dudas, Kari E. North, Sarah Nyante, Adesola Ogunniyi, Elaine A. Ostrander, George Papanicolaou, Sanjay Patel, Curtis A. Pettaway, Michael F. Press, Susan Redline, Jorge L. Rodriguez-Gil, Charles Rotimi, Benjamin A. Rybicki, Babatunde Salako, Pamela J. Schreiner, Lisa B. Signorello, Andrew B. Singleton, Janet L. Stanford, Alex H. Stram, Daniel O. Stram, Sara S. Strom, Bhoom Suktitipat, Michael J. Thun, John S. Witte, Lisa R. Yanek, Regina G. Ziegler, Wei Zheng, Xiaofeng Zhu, Joseph M. Zmuda, Alan B. Zonderman, Michele K. Evans, Yongmei Liu, Diane M. Becker, Richard S. Cooper, Tomi Pastinen, Brian E. Henderson, Joel N. Hirschhorn, Guillaume Lettre, and Christopher A. Haiman
- Subjects
Genetics ,QH426-470 - Published
- 2011
- Full Text
- View/download PDF
13. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
- Author
-
Amidou N'Diaye, Gary K Chen, Cameron D Palmer, Bing Ge, Bamidele Tayo, Rasika A Mathias, Jingzhong Ding, Michael A Nalls, Adebowale Adeyemo, Véronique Adoue, Christine B Ambrosone, Larry Atwood, Elisa V Bandera, Lewis C Becker, Sonja I Berndt, Leslie Bernstein, William J Blot, Eric Boerwinkle, Angela Britton, Graham Casey, Stephen J Chanock, Ellen Demerath, Sandra L Deming, W Ryan Diver, Caroline Fox, Tamara B Harris, Dena G Hernandez, Jennifer J Hu, Sue A Ingles, Esther M John, Craig Johnson, Brendan Keating, Rick A Kittles, Laurence N Kolonel, Stephen B Kritchevsky, Loic Le Marchand, Kurt Lohman, Jiankang Liu, Robert C Millikan, Adam Murphy, Solomon Musani, Christine Neslund-Dudas, Kari E North, Sarah Nyante, Adesola Ogunniyi, Elaine A Ostrander, George Papanicolaou, Sanjay Patel, Curtis A Pettaway, Michael F Press, Susan Redline, Jorge L Rodriguez-Gil, Charles Rotimi, Benjamin A Rybicki, Babatunde Salako, Pamela J Schreiner, Lisa B Signorello, Andrew B Singleton, Janet L Stanford, Alex H Stram, Daniel O Stram, Sara S Strom, Bhoom Suktitipat, Michael J Thun, John S Witte, Lisa R Yanek, Regina G Ziegler, Wei Zheng, Xiaofeng Zhu, Joseph M Zmuda, Alan B Zonderman, Michele K Evans, Yongmei Liu, Diane M Becker, Richard S Cooper, Tomi Pastinen, Brian E Henderson, Joel N Hirschhorn, Guillaume Lettre, and Christopher A Haiman
- Subjects
Genetics ,QH426-470 - Abstract
Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10(-12) and 2p14-rs4315565, P = 1.2×10(-8)). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10(-4) for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P
- Published
- 2011
- Full Text
- View/download PDF
14. A multi-centre observational study of HIV, tuberculosis and risk of chronic lung disease in urban West Africa
- Author
-
Douglas L. Fink, David A. Oladele, Abigail J. Slack, Oluwatosin Odubela, Tomilola Musari-Martins, Adaobi Okechukwu, Kemi Adetayo, Sola Opaneye, Rufai Abubakar, Agatha David, James Cai, Shumonta Quaderi, Ibrahim Abubakar, Oliver Ezechi, John R. Hurst, Marc Lipman, and Babatunde Salako
- Subjects
Lung Diseases ,Africa, Western ,Cross-Sectional Studies ,Infectious Diseases ,Risk Factors ,Biofuels ,Immunology ,Prevalence ,Humans ,Nigeria ,Tuberculosis ,Immunology and Allergy ,HIV Infections - Abstract
HIV and tuberculosis (TB) are risk factors for non-communicable chronic lung disease (CLD). Despite the high prevalence of these infections in West Africa, there are no studies that compare CLD between people with HIV and HIV-negative populations in this setting. This study sought to quantify the contribution of HIV and TB infection in addition to conventional CLD risk factors, such as tobacco and biofuel exposure, to CLD in urban West Africa.A multi-centre cross-sectional study was conducted in three community clinics in Lagos, Nigeria between 2018 and 2019.Spirometry, questionnaires and clinical records were used to estimate prevalence of CLD and association with risk factors.In total, 148 HIV-negative individuals and 170 HIV-positive individuals completed the study. Current cigarette (11 of 318, 3.5%) and lifetime domestic biofuel (6 of 318, 1.8%) exposures were low. Airway obstruction (33 of 170, 19.4% vs. 12 of 148, 8.1%, P = 0.004) and CLD (73 of 170, 42.9% vs. 34 of 148, 23%, P 0.0001) were more prevalent in people with HIV compared with the HIV-negative group. HIV infection [odds ratio 2.35 (1.33, 4.17), P = 0.003] and history of TB [odds ratio 2.09 (1.04, 4.20), P = 0.038] were independently associated with increased risk of CLD.HIV and TB far outweigh conventional risk factors, including tobacco and domestic biofuel exposure, as drivers of non-communicable CLD in urban West Africa. Current global policy for CLD may have limited impact on CLD in this setting. Enhanced prevention, diagnosis and management strategies for incident HIV and TB infections are likely to have a significant impact on long-term lung health in sub-Saharan Africa.
- Published
- 2022
15. SARS-CoV-2 Antibody Responses to AZD1222 Vaccination in West Africa
- Author
-
Adam Abdullahi, David Oladele, Michael Owusu, Steven Kemp, James Ayorinde, Abideen Salako, Douglas Fink, Augustina Sylverken, Fehintola Ige, Chika Onwuamah, Kwame Boadu, Qosim Osuolale, James Opoku Frimpong, Rufai Abubakar, Azuka Okuruawe, Gideon Liboro, Lawrence Agyemang, Nana Kwame Ayisi-Boateng, Oluwatosin Odubela, Gregory Ohihoin, Oliver Ezechi, Japhet Kamasah, Emmanuel Ameyaw, Joshua Arthur, Derrick Kyei, Dorcas Owusu, Olagoke Usman, Sunday Mogaji, Adedamola Dada, George Agyei, Soraya Ebrahimi, Lourdes Gutierrez, Sani Aliyu, Rainer Doffinger, Rosemary Audu, Richard Adegbola, Petra Mlcochova, Richard Phillips, Babatunde Salako, and Ravindra Gupta
- Abstract
There is a paucity of real-world data on vaccine elicited neutralising antibody responses for AZD1222, in African populations following vaccination scale up. Here, we first measured baseline SARS-CoV-2 seroprevalence and levels of protective neutralizing antibodies prior to vaccination rollout using both flow cytometric based analysis of binding antibodies coupled with pseudotyped virus neutralisation assays in two study cohorts from West Africa: Nigerian healthcare workers; (n = 140) and a Ghanaian general community cohort (n = 527). We found that 44% and 28% of pre-vaccination participants showed IgG anti-N positivity, increasing to 59% and 42% respectively with anti-receptor binding dominan (RBD) IgG specific antibodies. The increased prevalence of prior exposure using anti RBD antibodies was corroborated by Pseudotyped virus (PV) neutralizing antibody assays, indicating that overall, 50% of prior infections were missed by N antibody testing. PV titres (serum dilution required to inhibit 50% of infection, ID50) against wild type following 2-dose vaccination regimen were [145 (4.5) to 2579 (4.2) vs 57 (3.0) to 1049 (6.7)] (GMT ± s.d), delta [75 (3.0) to 549 (3.7) vs 37 (2.4) to 453 (7.4)] (GMT ± s.d) and omicron variants [37 (2.4) to 453 (7.4) vs 29 (1.8) to 95 (5.3)] (GMT ± s.d) in the Nigerian (1 month) vs Ghanaian participants (2 months) post vaccination (total n = 94). Previous IgG anti-N was associated with significantly higher neutralizing antibody levels with an observed 3.5-fold [1423 (3.9) vs 4674 (3.4)] (GMT ± s.d) and 2.7-fold [779 (7.1) vs 2128 (4.8) (GMT ± s.d) difference between N positive and negative participants in the Nigerian and Ghanaian cohorts respectively. We also observed serological evidence from N, S and RBD antibodies of breakthrough infection in 8/49 (16%) of Nigerian vaccinees over only 2 months, with neutralisation profiles suggesting delta variant infection consistent with the sampling period when this variant was known to dominate. Importantly, neutralising antibodies waned at 3 months after second dose vs 1 month post second-dose 1695 (4.3)] vs 2579 (4.2) in the Nigerian population who were N negative throughout. IgG anti-N was also observed to wane below cut-off in a total 19/94 (20%) of subjects highlighting the need for a combination of additional markers to characterise previous infection. We conclude that AZD1222 is immunogenic in two independent real world West African cohorts with high background seroprevalence and incidence of breakthrough infection in 2021. Waning titres at 6 months post second dose indicates the need for booster dosing after AZD1222 in the African setting despite hybrid immunity from previous infection.
- Published
- 2022
16. The trend of SARS-CoV-2 variants from July 2021 to Jan 2022 in metropolitan Lagos, the epicentre of the COVID-19 pandemic in Nigeria
- Author
-
Chika Onwuamah, Bamidele Iwalokun, Rahaman Ahmed, Emuejevoke Toye, Olufemi Amoo, Nnaemeka Ndodo, Esther Momoh, Azuka Okwuraiwe, Ayorinde James, Chika Okoli, Chimaobi Chukwu, Joseph Shaibu, Muinahj Fowora, Janet Fayemi, Tochukwu Onuigbo, Mfon Sunday, Victor Ogbolu, Maureen Otuonye, Nwando Mba, Rosemary Audu, Oliver Ezechi, Akin Abayomi, Ifedayo Adetifa, and Babatunde Salako
- Abstract
Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits a high mutations rate and monitoring its spread and evolution is essential for global control of the pandemic. This study determined the SARS-CoV-2 variants circulating in Lagos, from July 2021 to January 2022, when the nation experienced its third and fourth waves.The study utilised archived SARS-CoV-2 positive samples and Midnight whole-genome sequencing workflow from Oxford Nanopore Technologies. Six hundred and sixty-six archived SARS-CoV-2 positive samples, 488 community testing and 178 travellers were analysed. Three hundred forty-one sequences samples were assigned lineages, but 327 sequences with doubly verified collection dates recreated the timeline. 86.5% of the samples came from persons between 16 and 60 years old. Two infections with the Omicron variant (BA.1) among community testers were detected in August 2021 and from seven outbound travellers in September 2021. An inbound traveller also had the Omicron variant (BA.1) in September 2021. Thirteen lineages of the Delta variant and four lineages of the Omicron variant were detected.We show that the Omicron variant was in Nigeria before November 2021 and could have caused the short reprieve between the third and fourth waves. Several lineages detected suggest several introductions, highlighting the need for surveillance.
- Published
- 2022
17. End COVID-19 in low- and middle-income countries
- Author
-
Ahmed Mushfiq Mobarak, Edward Miguel, Jason Abaluck, Amrita Ahuja, Marcella Alsan, Abhijit Banerjee, Emily Breza, Arun G. Chandrasekhar, Esther Duflo, James Dzansi, Denise Garrett, Paul Goldsmith-Pinkham, Gregg S. Gonsalves, Muhammad Maqsud Hossain, Aleksandra Jakubowski, Gagandeep Kang, Arjun Kharel, Michael Kremer, Niccolo Meriggi, Carol Nekesa, Benjamin A. Olken, Saad B. Omer, Firdausi Qadri, Helen Rees, Babatunde Salako, Maarten Voors, Shana Warren, and Witold Więcek
- Subjects
Multidisciplinary ,Biomedical Research ,COVID-19 Vaccines ,Vaccination Coverage ,Masks ,COVID-19 ,India ,WASS ,Ontwikkelingseconomie ,Cell Phone Use ,Development Economics ,Communicable Disease Control ,Life Science ,Humans ,Vaccination Hesitancy ,Developing Countries - Published
- 2022
18. PUBLIC HEALTH SURVEILLANCE FOR ADVERSE EVENTS FOLLOWING COVID-19 VACCINATION IN AFRICA
- Author
-
AbdulAzeez Anjorin, Ismail Odetokun, Jean Nyandwi, Hager Elnadi, Kwame Awiagah, Joseph Eyedo, Ajibola Abioye, George Gachara, Aala Maisara, Youssef Razouqi, Yusuf Mohamud Mohamed, Zuhal Mhgoob, Tunde Ajayi, Lazare Ntirenganya, Morounke Saibu, Babatunde Salako, Nusirat Elelu, Kikelomo Wright, Folorunsho Fasina, and Rasha Mosbah
- Abstract
Background: The death toll and economic disaster caused by SARS-CoV-2/ COVID-19 is still on the rise globally and in Africa with a case fatality ratio (CFR), 2.58 from 220,958 deaths out of 8,556,890 cases recorded across the continent as of 14th November 2021. Local, national and international health agencies have advocated multi-pronged public health strategies to limit infections and prevent deaths. The availability of a safe and effective vaccine is critical in the control of a pandemic. Several adverse events have been reported globally for different vaccines including COVID-19 with limited or no data from Africa. Methods: This cross-sectional epidemiological study investigated the adverse events following COVID-19 vaccination in Africans between April- June, 2021 using a structured questionnaire distributed via the web for public health surveillance. Results: Out of the 1200 participants recruited, a total of 80.8% (n = 969) respondents from 35 countries including 22 African countries and 13 countries where Africans live in the diaspora reported different adverse events following COVID-19 vaccination. More than half of the vaccinee were male (53.0%) and frontline healthcare workers (55.7%), respectively. A total of 15.6% (n = 151) reported previous exposure to SARS-CoV-2 while about one-fourth, 24.8% (n = 240) reported different underlying health conditions prior to vaccination. Fatal cases were 5.1% (n = 49) while other significant heterogenous events were reported in three categories: very common, common, and uncommon adverse events including enlarged lymph nodes 2.4% (n = 23), menstrual disorder 0.5% (n = 5), and increased libido 0.2% (n = 2). Conclusions: The study provided useful data for concerned authorities and institutions to prepare plans that will address issues related to COVID-19 vaccines.
- Published
- 2022
19. A New Testable Theory on Deviations from Covered Interest Rate Parity
- Author
-
Abdul-Muttolib Babatunde Salako
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
20. A New Testable Theory on Deviations from Covered Interest Rate Parity
- Author
-
Babatunde Salako, Abdul-Muttolib, primary
- Published
- 2022
- Full Text
- View/download PDF
21. Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement
- Author
-
Christopher Esezobor, Adebowale D. Ademola, Adewale E. Adetunji, Emmanuel A. Anigilaje, Anthony Batte, Fatima N. Jiya-Bello, Francis F. Furia, Uzoamaka Muoneke, Mignon McCulloch, Peter Nourse, Patience Obiagwu, Odutola Odetunde, Perditer Okyere, Adaobi Solarin, Elliot K. Tannor, Damien Noone, Rasheed Gbadegesin, Rulan S. Parekh, Gloria Ashuntantang, Guemkam Georgette, Dwamoa Adu, Victoria May Adabayeri, Vincent Boima, Charlotte Osafo, Elliot Koranteng Tannor, Sampson Antwi, Jacob Plange-Rhule, Manmak Mamven, Samuel Ajayi, Emmanuel Anigilaje, Ogochukwu Okoye, Ofejiro Okperi, Okiroro Ighosewe, Ifeoma Ulasi, Henrietta U. Okafor, Babatunde Salako, Adebowale Ademola, Kemi Amodu, Yemi Raji, Asinobi O. Adanze, Fatiu Arogundade, Wasiu Olowu, Timothy Olusegun Olanrewaju, Olanrewaju Adedoyin, Aliyu Abdu, Oluwatoyin Amira, Charles Odenigbo, Nonyelum Jisieike-Onuigbo, Adesola Musa, Rosemary Audu, Olanrewaju Jinadu, Muhammad Makusidi, Fatima Nma Jiya Bello, Jacob Olugbenga Awobusuyi, Francis Frederick Furia, Paschal Ruggajo, Jacqueline Shoo, Robert Kalyesubula, Grace Kansiime, Jovanka Vasilevska-Ristovska, Tonny H.M. Banh, Akinlolu O. Ojo, Jillian Wilson, Donna Smith, and Titilayo Ilori
- Subjects
Pediatrics ,medicine.medical_specialty ,Sub saharan ,business.industry ,Statement (logic) ,030232 urology & nephrology ,MEDLINE ,Childhood nephrotic syndrome ,Steroid sensitive ,medicine.disease ,Idiopathic Nephrotic Syndrome ,Steroid resistant ,Article ,03 medical and health sciences ,0302 clinical medicine ,Nephrology ,Medicine ,030212 general & internal medicine ,business ,Nephrotic syndrome - Published
- 2020
22. Covid-19 preparedness and response: experiences of the Nigerian Institute for Medical Research
- Author
-
Rosemary Audu, Chika Onwuamah, Azuka Okwuraiwe, Olufemi Amoo, Ayorinde James, Joseph Shaibu, Fehintola Ige, Aigbe Ohihoin, Agatha David, Gideon Liboro, Ebenezer Odewale, Judith Sokei, Chika Okoli, Dominic Achanya, Adesegun Adesesan, Bosede Amuda, Ponmak Jamda, Rahaman Ahmed, Muinah Fowora, Olugbenga Aina, Oliver Ezechi, Righard Adegbola, and Babatunde Salako
- Abstract
The global community is facing a health crisis caused by coronavirus disease 2019 (COVID-19). The coronavirus pandemic is severely disrupting the global economy. Countries are battling to slow the spread of the virus by testing, employing contact tracing, restricting travel, quarantining citizens, and encouraging use of face mask, hand hygiene and social distancing measures. The lockdown imposed in many countries including Nigeria has resulted in increased cost and shortages of reagents and supplies worldwide. Due to the highly contagious nature of the disease, rapid rate of spread, and lack of an effective therapy, it became necessary for nations of the world to mount an efficient response mechanism to curb the spread of the pandemic. The Nigerian Institute of Medical Research (NIMR) has responded actively to the current pandemic with some innovations with respect to sample collection systems, molecular diagnostics, kit development and validation. Due to the highly infectious nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the causative agent of COVID-19, the institute also invested in the production of infection control tools. The extent of response by the institute would not have been possible but for collaboration and partnership with well-meaning organizations and stakeholders. National, State and public cooperation are very essential for effective response to any pandemic. The response of NIMR to the pandemic is herein discussed. Lessons learned and recommendations made are also shared to help institutions interested in combating this and future pandemics of similar nature.
- Published
- 2020
23. MOESM1 of Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study
- Author
-
Onwuamah, Chika, Okpokwu, Jonathan, Audu, Rosemary, Imade, Godwin, Meloni, Seema, Azuka Okwuraiwe, Chebu, Philippe, Adesola Musa, Chaplin, Beth, Dalhatu, Ibrahim, Oche Agbaji, Samuels, Jay, Ezechi, Oliver, Ahmed, Mukhtar, Odaibo, Georgina, Olaleye, David, Okonkwo, Prosper, Babatunde Salako, Raizes, Elliot, Chunfu Yang, Kanki, Phyllis, and Idigbe, Emmanuel
- Abstract
Additional file 1. Study Population. Gives greater details about the study population and how the participants were selected.
- Published
- 2020
- Full Text
- View/download PDF
24. First Nigerian Bioinformatics Conference (FNBC): Towards a dynamic bioinformatics community
- Author
-
ThankGod E. Ebenezer, Itunuoluwa Isewon, Elijah Kolawole Oladipo, Olaitan Awe, Marion Adebiyi, Yvonne Ajamma, Nusrah Bolatito Afolabi-Balogun, Emuejevoke T. Toye, Deborah E. Fasesan, Zainab A. Kashim, Olugbenga Oluwagbemi, Jelili Oyelade, Faith Ogbole, Benjamin Benthai, Ijeoma Asilebo, Abati Abraham, Tawakalt Olasumbo Oduwole, Emmanuel Adamolekun, Charles Oluwaseun Adetunji, Umar Ahmad, Abdulfatai Tijjani, Callistus Akinleye, Victor Chukwudi Osamor, Chika Onwuamah, Olufemi Amoo, Idowu A. Taiwo, Bamidele Abiodun Iwalokun, Chinwe Ekenna, Babatunde Salako, Ezekiel Adebiyi, Oyekanmi Nashiru, and Segun Fatumo
- Abstract
The human genome project, which was completed in 2003, ushered in a new era of scientific applications in medicine and bioscience, and also enhanced the generation of high-throughput data which required laboratory and computational analytical approaches in fields known as genomics and bioinformatics respectively. Internationally, specific advances have been achieved which involved the formation and emergence of strong scientific communities to sustain these technological advancements. On the African continent and regionally, the Human Hereditary and Health in Africa (H3Africa), Biosciences eastern and central Africa - International Livestock Research Institute (BecA - ILRI) Hub, and the Alliance for Accelerated Crop Improvements in Africa (ACACIA), are helping to push some of these advances in human health, biosciences, and agriculture respectively. In Nigeria, we believe that significant advances have also been made by various groups since the human genome project was completed. However, a scientific gathering platform to sustainably enable scientists discuss and update these progresses remained elusive. In this article, we report the First Nigerian Bioinformatics Conference (FNBC) hosted by the Nigerian Bioinformatics and Genomics Network (NBGN) in collaboration with the Nigerian Institute of Medical Research (NIMR). The conference was held from 24th - 26th June, 2019, with the theme: “Bioinformatics in the era of genomics in Africa”. Quantitatively, the conference recorded 195 online registered participants, and up to 186 actual participants; comprising of 8 keynote speakers, 6 invited speakers, 25 oral presenters, 83 poster presenters, and up to 73 non-presenting participants. Attendees with national (up to 179) and international (up to 16) affiliations also participated at the conference. Qualitatively, broad scope of bioinformatics, genomics and molecular biology presentations in biomedicine, health, and biosciences were featured at the conference. We discuss the conference structure and activities, lessons learned, and way forward for future bioinformatics conferences in Nigeria. We further discuss the relevance of the conference which presents an increased visibility for the Nigerian bioinformatics community, positions Nigeria as a dynamic community player within the African bioinformatics space, and provides a platform for national impact through the application and implementation of the benefits of bioinformatics.
- Published
- 2019
25. Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations
- Author
-
Nora Franceschini, Ervin Fox, Zhaogong Zhang, Todd L. Edwards, Michael A. Nalls, Yun Ju Sung, Bamidele O. Tayo, Yan V. Sun, Omri Gottesman, Adebawole Adeyemo, Andrew D. Johnson, J. Hunter Young, Ken Rice, Qing Duan, Fang Chen, Yun Li, Hua Tang, Myriam Fornage, Keith L. Keene, Jeanette S. Andrews, Jennifer A. Smith, Jessica D. Faul, Zhang Guangfa, Wei Guo, Yu Liu, Sarah S. Murray, Solomon K. Musani, Sathanur Srinivasan, Digna R. Velez Edwards, Heming Wang, Lewis C. Becker, Pascal Bovet, Murielle Bochud, Ulrich Broeckel, Michel Burnier, Cara Carty, Daniel I. Chasman, Georg Ehret, Wei-Min Chen, Guanjie Chen, Wei Chen, Jingzhong Ding, Albert W. Dreisbach, Michele K. Evans, Xiuqing Guo, Melissa E. Garcia, Rich Jensen, Margaux F. Keller, Guillaume Lettre, Vaneet Lotay, Lisa W. Martin, Jason H. Moore, Alanna C. Morrison, Thomas H. Mosley, Adesola Ogunniyi, Walter Palmas, George Papanicolaou, Alan Penman, Joseph F. Polak, Paul M. Ridker, Babatunde Salako, Andrew B. Singleton, Daniel Shriner, Kent D. Taylor, Ramachandran Vasan, Kerri Wiggins, Scott M. Williams, Lisa R. Yanek, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Gerald Berenson, Eric Boerwinkle, Erwin Bottinger, Mary Cushman, Charles Eaton, Fredrik Nyberg, Gerardo Heiss, Joel N. Hirschhron, Virginia J. Howard, Konrad J. Karczewsk, Matthew B. Lanktree, Kiang Liu, Yongmei Liu, Ruth Loos, Karen Margolis, Michael Snyder, Bruce M. Psaty, Nicholas J. Schork, David R. Weir, Charles N. Rotimi, Michele M. Sale, Tamara Harris, Sharon L.R. Kardia, Steven C. Hunt, Donna Arnett, Susan Redline, Richard S. Cooper, Neil J. Risch, D.C. Rao, Jerome I. Rotter, Aravinda Chakravarti, Alex P. Reiner, Daniel Levy, Brendan J. Keating, Xiaofeng Zhu, Min Jin Go, Young Jin Kim, Jong-Young Lee, Jae-Pil Jeon, Sung Soo Kim, Bok-Ghee Han, Yoon Shin Cho, Xueling Sim, Wan Ting Tay, Rick Twee Hee Ong, Mark Seielstad, Jian Jun Liu, Tin Aung, Tien Yin Wong, Yik Ying Teo, E. Shyong Tai, Chien-Hsiun Chen, Li-ching Chang, Yuan-Tsong Chen, Jer-Yuarn Wu, Tanika N. Kelly, Dongfeng Gu, James E. Hixson, Jiang He, Yasuharu Tabara, Yoshihiro Kokubo, Tetsuro Miki, Naoharu Iwai, Norihiro Kato, Fumihiko Takeuchi, Tomohiro Katsuya, Toru Nabika, Takao Sugiyama, Yi Zhang, Wei Huang, Xuegong Zhang, Xueya Zhou, Li Jin, Dingliang Zhu, Bochud, Murielle, and Ehret, Georg Benedikt
- Subjects
Blood Pressure/genetics ,Black People ,Genome-wide association study ,Locus (genetics) ,Blood Pressure ,030204 cardiovascular system & hematology ,Biology ,Quantitative trait locus ,Polymorphism, Single Nucleotide ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Quantitative Trait, Heritable ,Report ,Databases, Genetic ,Genetics ,Humans ,Genetics(clinical) ,Genetic Predisposition to Disease ,Gene ,Genetics (clinical) ,030304 developmental biology ,Genetic association ,ddc:616 ,0303 health sciences ,African Continental Ancestry Group/genetics ,Reproducibility of Results ,Polymorphism, Single Nucleotide/genetics ,3. Good health ,Genetic Loci ,Meta-analysis ,Multiple comparisons problem ,Genetic Loci/genetics ,Africa ,Trait ,Genome-Wide Association Study - Abstract
High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 × 10(-8)) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability.
- Published
- 2013
26. Urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in Ibadan, Nigeria
- Author
-
Aderemi, Kehinde, Kayode, Adedapo, Chris, Aimakhu, Akin-Tunde, Odukogbe, Oladapo, Olayemi, and Babatunde, Salako
- Subjects
Adult ,Treatment Outcome ,Adolescent ,Anti-Infective Agents ,Bacteriuria ,Enterobacteriaceae ,Pregnancy ,Surveys and Questionnaires ,Enterobacteriaceae Infections ,Humans ,Nigeria ,Female ,Pregnancy Complications, Infectious - Abstract
To determine the bacterial agents involved in urinary tract infections in pregnant women and their antibiotic susceptibility patterns in Ibadan, Nigeria.All consenting subjects who attended antenatal clinics of the University College Hospital and Adeoyo Maternity Hospital, Ibadan, Nigeria, from 1 April 2007 and 30 March 2009 were interviewed to obtain demographic and pregnancy health data. Mid-stream urine samples obtained were processed by standard methods. Confirmed bacterial isolates were tested against seven antibiotics using the Kirby-Bauer disc diffusion technique.Of the 473 specimens processed, 136 (28.8%) were positive for microscopy, 118 (25.0%) were culture positive, while 18 (3.8%) were microscopy positive but negative for culture. More than 90% of the bacterial isolates were Gram-negative bacilli, of which approximately 80% were members of the family Enterobacteriaceae. Klebsiella oxytoca accounted for 45 (38.1%) of the causative agents identified, followed by Escherichia coli (31.3%), Pseudomonas aeruginosa (9.3%) and Proteus mirabilis (6.8%). Candida albicans accounted for three (2.6%) of the isolates. Ten isolates (22.2%) of K. oxytoca were resistant to cefuroxime while three (6.7%) were resistant to ofloxacin. The only Gram-positive bacterium isolated, Staphylococcus saprophyticus, accounted for four (4.3%) of all pathogens, of which three (75.0%) were susceptible to nitrofurantoin, ofloxacin, cefuroxime and the amoxicillin-clavulanic acid combination.In conclusion, the incidence of culture-positive urinary tract infection in pregnancy is common in Ibadan. More studies are needed to evaluate the susceptibility profile of uropathogens to commonly used antibiotics in our environment.
- Published
- 2011
27. Influence of previous abortions and new paternity on the risk of hypertension in nulliparous parturients in Ibadan: a cohort study
- Author
-
Oladapo, Olayemi, Donna, Strobino, Kayode, Adedapo, Christopher, Aimakhu, Akin-Tunde, Odukogbe, and Babatunde, Salako
- Subjects
Adult ,Cohort Studies ,Parity ,Logistic Models ,Pregnancy ,Risk Factors ,Odds Ratio ,Humans ,Nigeria ,Abortion, Induced ,Female ,Paternity ,Hypertension, Pregnancy-Induced - Abstract
This study aims to determine the influence of previous abortions and new paternity on the risk of hypertension in a cohort of nulliparous women.A prospective cohort study was conducted with development of hypertension in pregnancy as outcome variable. Explanatory variables were previous abortions and paternity. Univariate analysis was by t-test, χ(2) test and Fisher's exact test where applicable. Logistic regression was utilized for multivariate analysis. Stata was utilized for all the analyses. The level of statistical significance was set as P0.05.Same paternity abortions reduced the risk of hypertension (OR 0.48, 95% CI 0.31-0.73). Previous abortions did not reduce the odds of hypertension in pregnancy (OR 1.25, 95% CI 0.83-1.88). Rural dwelling reduced the odds of developing hypertension in pregnancy (OR 0.54, 95% CI 0.42-0.70).The result of this study supports the immunological theory of the etiology of hypertension in pregnancy.
- Published
- 2010
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.