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7 results on '"Baaklini, Sabrina"'

2. A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes

Author

Baaklini, Sabrina, Sarrabay, Alexandre, Barthelemy, Camille, Dahbi, Laila, Gil, Laurine, Mossadegh-Keller, Noushin, Navarro, Jean-Marc, Huber, Caroline, Fenouil, Romain, Escaliere, Bertrand, Trombetta, Romane, Pujol, Marine, Gaulard, Philippe, Riviere, Benjamin, Dartigues, Peggy, Llamas Gutierrez, Francesco, Pangault, Celine, Jardin, Fabrice, Lemonnier, Francois, Brisou, Gabriel, Haioun, Corinne, Gravelle, Pauline, Laurent, Camille, Spinelli, Lionel, Huang, C Chris, Stokes, Matthew E, Seth, Sahil, Ortiz, Maria, Gandhi, Anita K., Nadel, Bertrand, Milpied, Pierre, and Roulland, Sandrine

Published
2023
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3. Emergence of Highly-Plastic B Cell States Cooperates with Early Immune Microenvironment Remodeling to Drive Follicular Lymphomagenesis

Author

Brisou, Gabriel, Baaklini, Sabrina, Mossadegh-Keller, Noushin, Beyou, Alicia, Zala, Manon, Gil, Laurine, Soun, Camille, Huber, Caroline, Cervera-Marzal, Iñaki, Bru, Agnés, Potier, Delphine, Gon, Stéphanie, Chasson, Lionel, Antoranz, Asier, Pey Perez, Jon, Gandhi, Anita K., Nakayama, Yumi, Hagner, Patrick R, Milpied, Pierre, Nadel, Bertrand, and Roulland, Sandrine

Published
2023
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6. NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients

Author

Thiam, Alassane, primary, Baaklini, Sabrina, additional, Mbengue, Babacar, additional, Nisar, Samia, additional, Diarra, Maryam, additional, Marquet, Sandrine, additional, Fall, Mouhamadou Mansour, additional, Sanka, Michel, additional, Thiam, Fatou, additional, Diallo, Rokhaya Ndiaye, additional, Torres, Magali, additional, Dieye, Alioune, additional, and Rihet, Pascal, additional

Published
2018
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7. Beyond genome-wide scan: Association of a cis-regulatory NCR3 variant with mild malaria in a population living in the Republic of Congo

Author

Baaklini, Sabrina, Afridi, Sarwat, Nguyen, Thy Ngoc, Koukouikila-Koussounda, Felix, Ndounga, Mathieu, Imbert, Jean, Torres, Magali, Pradel, Lydie, Ntoumi, Francine, Rihet, Pascal, Technologies avancées pour le génôme et la clinique (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Marien Ngouabi, Centre d’Etudes sur les Ressources Végétales, Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Rihet, Pascal

Subjects
Male, Cytotoxicity, lcsh:Medicine, Gene Expression, Artificial Gene Amplification and Extension, NK cells, Toxicology, Pathology and Laboratory Medicine, Biochemistry, Polymerase Chain Reaction, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cellular types, Medicine and Health Sciences, Malaria, Falciparum, lcsh:Science, Promoter Regions, Genetic, Protozoans, Immune cells, Malarial Parasites, Eukaryota, STAT4 Transcription Factor, Enzymes, Congo, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, White blood cells, Female, Oxidoreductases, Luciferase, Research Article, Cell biology, Blood cells, Immunology, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Research and Analysis Methods, Polymorphism, Single Nucleotide, parasitic diseases, DNA-binding proteins, Parasitic Diseases, Genetics, Humans, Genetic Predisposition to Disease, Gene Regulation, Molecular Biology Techniques, Molecular Biology, Alleles, Binding Sites, Natural Cytotoxicity Triggering Receptor 3, Biology and life sciences, lcsh:R, Organisms, Proteins, Tropical Diseases, Parasitic Protozoans, Malaria, Regulatory Proteins, Core Binding Factor Alpha 3 Subunit, HEK293 Cells, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Animal cells, Genetic Loci, Enzymology, lcsh:Q, K562 Cells, Transcription Factors
Abstract

International audience; Linkage studies have revealed a linkage of mild malaria to chromosome 6p21 that contains the NCR3 gene encoding a natural killer cell receptor, whereas NCR3-412G>C (rs2736191) located in its promoter region was found to be associated with malaria in Burkina Faso. Here we confirmed the association of rs2736191 with mild malaria in a Congolese cohort and investigated its potential cis-regulatory effect. Luciferase assay results indicated that rs2736191-G allele had a significantly increased promoter activity compared to rs2736191-C allele. Furthermore, EMSAs demonstrated an altered binding of two nuclear protein complexes to the rs2736191-C allele in comparison to rs2736191-G allele. Finally, after in silico identification of transcription factor candidates, pull-down western blot experiments confirmed that both STAT4 and RUNX3 bind the region encompassing rs2736191 with a higher affinity for the G allele. To our knowledge, this is the first report that explored the functional role of rs2736191. These results support the hypothesis that genetic variation within natural killer cell receptors alters malaria resistance in humans.

Published
2017

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