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2. Genetic Diversity and Characteristics of Drug Resistance Among Treatment-Naive People Living with HIV in Xi’an, China

Author

Xia H, Jin J, Ba H, Zhang Y, Li J, Guo R, Li Y, and Ma P

Subjects
human immunodeficiency virus, drug resistance, pre-treatment, china, Therapeutics. Pharmacology, RM1-950
Abstract

Huan Xia,1,2,&ast; Juan Jin,3,&ast; Huanhuan Ba,3 Yuan Zhang,3 Jiajia Li,3 Rui Guo,3 Ying Li,3 Ping Ma,1,2 Yan Zhang3 1Department of Infectious Diseases, Tianjin Second People’s Hospital, Tianjin, 300192, People’s Republic of China; 2Tianjin Association of STD/AIDS Prevention and Control, Tianjin, 300011, People’s Republic of China; 3Department of Infectious Diseases, Xi’an Eighth’s Hospital, Xi’an, Shaanxi, 710061, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Zhang, Xi’an Eighth’s Hospital, 2 Zhangba East Road, Yanta District, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel/Fax +86-29-85393973, Email 1522649620@qq.com Ping Ma, Tianjin Second People’s Hospital, 7 Sudi South Road, Nankai District, Tianjin, Tianjin, 300192, People’s Republic of China, Tel/Fax +86-22-27468129, Email mapingtianjin@163.comPurpose: The genetic diversity and genetic predisposition for drug resistance mutations are the primary features of human immunodeficiency virus type 1 (HIV-1), which could cause the incidence of failure of antiretroviral therapy (ART). This study investigates the distribution of various HIV-1 genotypes and the incidence of pretreatment drug resistance (PDR) in the antiretroviral-naive HIV-1 infected participants in Xi’an, China.Patients and Methods: In this study, a cross-sectional analysis was carried out at the Xi’an Eighth Hospital between January 2020 and December 2021 among newly-diagnosed ART-naive HIV-1 infected participants. A nested PCR technique was used for amplifying the target segment of 1.3 kb present in the pol gene that spanned the reverse transcriptase and the protease regions. HIV-1 genotypes and the PDR-associated mutations were identified using the Stanford HIV Drug Resistance Database.Results: A total of 317 pol gene sequences were retrieved, amplified, and sequenced. The circulating recombinant form (CRF), CRF07_BC (51.7%) was seen to be the most prevalent HIV-1 genotype, followed by other genotypes like CRF01_AE (25.9%), B (14.2%), and CRF55_01B (4.7%). PDR was found in 18.3% of the population. The PDR mutation frequency in the non-nucleoside reverse transcriptase inhibitor (NNRTI) (16.1%) was significantly higher compared to that of the nucleoside reverse transcriptase inhibitor (NRTI) (4.4%) and the protease inhibitor (0.9%). V179D/E (both were 4.4%) was seen to be the most predominant type of NNRTI mutation. K65R and M184V (1.3%) were the most frequent NRTI-associated mutations. About half (48.3%) of the sequenced HIV-1 strains that had mutations could show a potential low-level NNRTI resistance owing to V179D/E. Multivariate regression analysis revealed one PDR mutation associated with subtype CRF01_AE (p=0.002) and CRF55_01B (p< 0.001) as a higher risk mutation.Conclusion: Diverse and complex HIV-1 genotypes are distributed in Xi’an, China. Considering new evidence, it is necessary to screen for baseline HIV-1 drug resistance among the newly-diagnosed HIV-1 individuals.Keywords: human immunodeficiency virus, drug resistance, pre-treatment, China

Published
2023

5. Long-term prognosis of patients with permanent cardiac pacemaker indication in three referral cardiac centers in Cameroon: Insights from the National pacemaker registry

Author

Dzudie, A., Ngongang Ouankou, C., Nganhyim, L., Mouliom, S., Ba, H., Kamdem, F., Ndjebet, J., Nzali, A., Tantchou, C., Nkoke, C., Barche, B., Abanda, M., Metogo Mbengono, U.A., Hentchoya, R., Petipe Nkappe, C., Ouankou, M., Kouam Kouam, C., Mintom, P., Boombhi, J., Kuate Mfeukeu, L., Ngatchou, W., Kingue, S., and Ngowe Ngowe, M.

Published
2021
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10. Impact de la kinésithérapie chez les patients atteints de BPCO

Author

Koné, S., primary, Kanouté, T., additional, Soumaré, D., additional, Ouattara, K., additional, Sanogo, F.B., additional, Traoré, M., additional, Guindo, B., additional, Sidibé, F., additional, Sanogo, D., additional, Ba, H., additional, Sanogo, B., additional, and Toloba, Y., additional

Published
2024
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15. Modelling the lysine requirements of weaned piglets

Author

Rijpert, J.H.M., Nguyen Ba, H., Goethals, S., Millet, S., Bikker, P., Rijpert, J.H.M., Nguyen Ba, H., Goethals, S., Millet, S., and Bikker, P.

Abstract

In the Benelux, amino acid requirements for weaned piglets are based on over twenty years old experiments; these were recalculated last year by the Centraal Veevoederbureau (CVB, Central Bureau fo rLivestock Feeding) to a standardized basis. To provide up-to-date recommendations, a factorial growth model has been constructed to estimate the SID lysine requirements of nursery piglets. This report elucidates the construction, calibration and validation of this model.

Published
2023

16. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Author

Hamid, M.M.A., Abdelraheem, M.H., Acheampong, D.O., Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andagalu, B., Anderson, T., Andrianaranjaka, V., Aniebo, I., Aninagyei, E., Ansah, F., Ansah, P.O., Apinjoh, T., Arnaldo, P., Ashley, E., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Bouyou-Akotet, M., Branch, O., Bull, P.C., Cheah, H., Chindavongsa, K., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D.J., Corredor, V., Courtier, E., Craig, A., D'Alessandro, U., Dama, S., Day, N., Denis, B., Dhorda, M., Diakite, M., Djimde, A., Dolecek, C., Dondorp, A., Doumbia, S., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Enosse, S.M.M., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fleharty, M., Forbes, M., Fukuda, M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Harrison, G.L.A., Healy, Sara A., Hendry, J.A., Hernandez-Koutoucheva, A., Hien, T.T., Hill, C.A., Hombhanje, F., Hott, A., Htut, Y., Hussein, M., Imwong, M., Ishengoma, D., Jackson, S.A., Jacob, C.G., Jeans, J., Johnson, K.J., Kamaliddin, C., Kamau, E., Keatley, J., Kochakarn, T., Konate, D.S., Konaté, A., Kone, A., Kwiatkowski, D.P., Kyaw, M.P., Kyle, D., Lawniczak, M., Lee, S.K., Lemnge, M., Lim, P., Lon, C., Yavo, W., Pluijm, R.W. van der, Hamid, M.M.A., Abdelraheem, M.H., Acheampong, D.O., Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andagalu, B., Anderson, T., Andrianaranjaka, V., Aniebo, I., Aninagyei, E., Ansah, F., Ansah, P.O., Apinjoh, T., Arnaldo, P., Ashley, E., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Bouyou-Akotet, M., Branch, O., Bull, P.C., Cheah, H., Chindavongsa, K., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D.J., Corredor, V., Courtier, E., Craig, A., D'Alessandro, U., Dama, S., Day, N., Denis, B., Dhorda, M., Diakite, M., Djimde, A., Dolecek, C., Dondorp, A., Doumbia, S., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Enosse, S.M.M., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fleharty, M., Forbes, M., Fukuda, M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Harrison, G.L.A., Healy, Sara A., Hendry, J.A., Hernandez-Koutoucheva, A., Hien, T.T., Hill, C.A., Hombhanje, F., Hott, A., Htut, Y., Hussein, M., Imwong, M., Ishengoma, D., Jackson, S.A., Jacob, C.G., Jeans, J., Johnson, K.J., Kamaliddin, C., Kamau, E., Keatley, J., Kochakarn, T., Konate, D.S., Konaté, A., Kone, A., Kwiatkowski, D.P., Kyaw, M.P., Kyle, D., Lawniczak, M., Lee, S.K., Lemnge, M., Lim, P., Lon, C., Yavo, W., and Pluijm, R.W. van der

Abstract

Item does not contain fulltext, We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.

Published
2023

17. SNAPIG: a model to study nutrient digestion and absorption kinetics in growing pigs based on diet and ingredient properties

Author

Schop, M., Nguyen-Ba, H., Jansman, A.J.M., de Vries, S., Ellis, J.L., Bannink, A., Gerrits, W.J.J., Schop, M., Nguyen-Ba, H., Jansman, A.J.M., de Vries, S., Ellis, J.L., Bannink, A., and Gerrits, W.J.J.

Abstract

Current feed formulation and evaluation practices rely on static values for the nutritional value of feed ingredients and assume additivity. Hereby, the complex interplay among nutrients in the diet and the highly dynamic digestive processes are ignored. Nutrient digestion kinetics and diet × animal interactions should be acknowledged to improve future predictions of the nutritional value of complex diets. Therefore, an in silico nutrient-based mechanistic digestion model for growing pigs was developed: “SNAPIG” (Simulating Nutrient digestion and Absorption kinetics in PIGs). Aiming to predict the rate and extent of nutrient absorption from diets varying in ingredient composition and physicochemical properties, the model represents digestion kinetics of ingested protein, starch, fat, and non-starch polysaccharides, through passage, hydrolysis, absorption, and endogenous secretions of nutrients along the stomach, proximal small intestine, distal small intestine, and caecum + colon. Input variables are nutrient intake and the physicochemical properties (i.e. solubility, and rate and extent of degradability). Data on the rate and extent of starch and protein hydrolysis of different ingredients per digestive segment were derived from in vitro assays. Passage of digesta from the stomach was modelled as a function of feed intake level, dietary nutrient solubility and diet viscosity. Model evaluation included testing against independent data from in vivo studies on nutrient appearance in (portal) blood of growing pigs. When simulating diets varying in physicochemical properties and nutrient source, SNAPIG can explain variation in glucose absorption kinetics (postprandial time of peak, TOP: 20–100 min observed vs 25–98 min predicted), and predict variation in the extent of ileal protein and fat digestion (root mean square prediction errors (RMSPE) = 12 and 16%, disturbance error = 12 and 86%, and concordance correlation coefficient = 0.34 and 0.27). For amino acid absorptio

Published
2023

21. May Measurement Month 2019: an analysis of blood pressure screening results from Cameroon

Author

Dzudie, A, Njume, E, Mfekeu, LK, Djomou, A, Ba, H, Ndom, MS, Nkoke, C, Ndongo, S, Boombhi, J, Kamdem, F, Mouandjo, JPD, Mouliom, SA, Kouam, CK, Meli, H, Monkam, Y, Awungia, A, Serah, A, Tantchou, C, Ndjebet, J, Menanga, A, Beaney, T, Clarke, J, Poulter, NR, Kengne, AP, Kingue, S, and Cameroon Cardiac Society and MMM Cameroon investigator group

Subjects
Sample selection, medicine.medical_specialty, Control, Medicine, Statistical analysis, AcademicSubjects/MED00200, Systole, Stroke, Opportunistic screening, 1102 Cardiorespiratory Medicine and Haematology, Pregnancy, business.industry, Articles, Awareness, medicine.disease, Treatment, Blood pressure, Cardiovascular System & Hematology, Emergency medicine, Hypertension, Standard protocol, Screening, Cardiology and Cardiovascular Medicine, business, Cameroon Cardiac Society and MMM Cameroon investigator group
Abstract

The multi-country May Measurement Month (MMM) screening campaign aims to raise awareness on blood pressure (BP) and hypertension in individuals and communities, and measure BP, ideally, of those who had no BP measurement in the preceding year. We here report key findings from the Cameroon arm of MMM 2019. An opportunistic sample of adults (≥18 years) was included from 5 May to 5 June 2019 across 15 sites (markets, churches, homes, motor parks, workplaces, and hospitals/clinics). Data collection, cleaning, the definition of hypertension, and statistical analysis followed the standard protocol. The mean age of the 30 187 participants screened was 36.9 (SD: 14.9) years, 50.4% were female (5% of whom were pregnant), and 94.4% were screened out of the hospital/clinic settings. After multiple imputation of missing data, 6286 (20.8%) had hypertension, 24.0% were taking antihypertensive medication, and 705 (11.2%) of all participants with hypertension had controlled BP. In linear regression models adjusted for age, sex, and antihypertensive medicines use, a previous diagnosis of hypertension, a history of stroke, and use of antihypertensive medicines were significant predictors of systolic and diastolic BP levels. BPs were also significantly higher when measured in public outdoors, public indoors (diastolic BP only), workplaces, and other unspecified areas compared to hospitals/clinic settings. MMM19 is the largest ever BP screening campaign in a single month, in Cameroon and despite the limitations resulting from non-random sample selection, the opportunistic screening allows access to awareness and screening for hypertension out of the hospital/clinic settings.

Published
2021

25. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Author

Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., Ochola-Oyier, L.I., and MalariaGEN

Subjects
0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], 030231 tropical medicine, parasitic diseases, Medicine (miscellaneous), General Biochemistry, Genetics and Molecular Biology, 3. Good health
Abstract

Contains fulltext : 238195.pdf (Publisher’s version ) (Open Access) MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021
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26. ASPECTS CLINIQUES, PARACLINIQUES ET GENETIQUES DES ATAXIES SPINOCEREBELLEUSES AUTOSOMIQUES RECESSIVES AU MALI.

Author

Cissé, C. A. K., Cissé, L., Samassékou, O., Ba, H. O., Coulibaly, T., Diallo, S. H., Diallo, S., Taméga, A., Diarra, S., Maïga, A. B., Kané, F., Yalcouyé, A., Bocoum, A., Dembélé, M. E., Traoré, O., Simaga, A., Traoré, S. F., Keita, M., Fischbeck, K., and Traoré, M.

Abstract

Copyright of Mali Médical is the property of Mali Medical, Faculte de Medecine, de Pharmacie et d'Odonto-stomatologie and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

27. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.

Author

MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, Alyssa, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, Ye, H, MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, Alyssa, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, and Ye, H

Abstract

MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed.  Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

28. MMM17-Cameroon, analysis and opportunities—Sub-Saharan Africa

Author

Dzudie, A, Djomou, A, Ba, H, Njume, E, Ndom, MS, Mfekeu, LK, Ndongo, S, Kouam, CK, Awungia, A, Ze, S, Menanga, A, Kengne, AP, Xia, X, Beaney, T, Poulter, NR, Kingue, S, and Cameroon Cardiac Society and MMM Cameroon Investigator Group

Subjects
Sub saharan, Cardiovascular System & Hematology, business.industry, Diastole, MEDLINE, Medicine, Articles, Cardiology and Cardiovascular Medicine, business, Socioeconomics, 1102 Cardiorespiratory Medicine and Haematology, Cameroon Cardiac Society and MMM Cameroon Investigator Group
Abstract

Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. May Measurement Month (MMM) is a global initiative aimed at raising awareness on high BP and temporary increasing screening for hypertension worldwide. We here provide the results of the 2017 MMM (MMM17) edition in Cameroon. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2017 nationwide. BP measurement, the definition of hypertension and statistical analysis followed the standard MMM protocol. The campaign was advertised through various media and screening stations were set-up in local markets, churches, and outpatient departments of health facilities. In all, 16 093 individuals were screened during MMM17, of whom 4595 (29.2%) had hypertension. A total of 2742 (19.8%) of individuals not receiving anti-hypertensive medication were found to be hypertensive. Of those on medication, 1048 (57.2%) had uncontrolled BP. After adjusting for age, sex, and use of BP lowing medications, systolic and diastolic BPs were significantly higher in people on anti-hypertensive treatment, with higher waist circumference. MMM17 was the largest BP screening campaign undertaken in Cameroon, and although treatment and control rates are higher than previously reported, they are still well below optimum levels. MMM has highlighted the need for routine population-based surveys and suggests that opportunistic screening can identify significant numbers with raised BP.

Published
2019
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29. Subcutaneous Emphysema Associated with Pneumomediastinum and Complicated Pneumopericardium in a 14-Month-Old Infant

Author

Sacko, K., primary, Maiga, B., additional, Dembelé, G., additional, Togo, P., additional, Coulibaly, Y., additional, Dembélé, A., additional, Traoré, F., additional, Ba, H., additional, Touré, A., additional, Traoré, K., additional, Sidibé, N. L., additional, Diakité, F. L., additional, Sangaré, A., additional, Coulibaly, O., additional, Konaré, H., additional, Ahamadou, I., additional, Coulibaly, Y. A., additional, Cissé, M. E., additional, Sagara, S., additional, Konaté, D., additional, Doumbia, A. K., additional, Kanta, M., additional, Diall, H., additional, Maiga, L., additional, Fané, R., additional, Cissouma, A., additional, Traoré, N. L., additional, Niakaté, M., additional, and Diakité, A. A., additional

Published
2021
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32. ASPECTS EPIDEMIOLOGIQUE ET CLINIQUE DE LA FIBRILLATION AURICULAIRE AU SERVICE DE CARDIOLOGIE DU CHU DE KATI.

Author

Sonfo, B., Camara, Y., Thiam, C., Konaté, M., Maiga, A. K., Sacko, M., Sangaré, I., Touré, M., Cissé, Sidibé, S., Sangaré, Z., Camara, M., Daffé, S., Ba, H. O., Mariko, S., Dicko, Coulibaly, S., Menta, I., Diall, I., and Diarra, M. B.

Abstract

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Published
2022

34. Epidemio-Clinical, Therapeutic and Evolutive Aspects of Pulmonary Embolism in Young Subject in the Cardiology Department in Point “G” Hospital University Center Bamako

Author

Sako, M., primary, Sidibé, S., additional, Konaté, M., additional, Sonfo, B., additional, Diallo, N., additional, Diakité, M., additional, Thiam, C., additional, Keita, A., additional, Sangaré, I., additional, Ba, H. O., additional, Camara, Y., additional, Bouaré, L., additional, Koumaré, Y. R., additional, Coulibaly, S., additional, and Minta, I., additional

Published
2020
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35. Acetylcholine-induced Ciliary Beat of the Human Nasal Mucosa Is Regulated by the Pannexin-1 Channel and Purinergic P2X Receptor

Author

Ba H Do, Toyoaki Ohbuchi, Nobusuke Hohchi, Hideaki Suzuki, Tetsuro Wakasugi, Hiroki Koizumi, and Mitsuru Yokoyama

Subjects
0301 basic medicine, Adult, Male, Adolescent, Connexin, Mucous membrane of nose, Nerve Tissue Proteins, Turbinates, Connexins, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Immunology and Allergy, Medicine, Humans, Inositol 1,4,5-Trisphosphate Receptors, Cilia, 030223 otorhinolaryngology, Ciliary beating, Receptor, Cells, Cultured, Aged, Rhinitis, Aged, 80 and over, business.industry, Purinergic receptor, General Medicine, Pannexin, Middle Aged, Acetylcholine, Cell biology, Nasal Mucosa, 030104 developmental biology, medicine.anatomical_structure, Otorhinolaryngology, Mucociliary Clearance, Receptors, Purinergic P2X, Chronic Disease, Carbenoxolone, Female, business, medicine.drug, Respiratory tract, Signal Transduction
Abstract

BackgroundAirway mucociliary transport is an important function for the clearance of inhaled foreign particulates in the respiratory tract. The present study aimed at investigating the regulatory mechanism of acetylcholine (Ach)-induced ciliary beat of the human nasal mucosa in ex vivo.MethodsThe inferior turbinate mucosa was collected from patients with chronic hypertrophic rhinitis during endoscopic surgery. The mucosa was cut into thin strips, and ciliary movement was observed under a phase-contrast light microscope with a high-speed digital video camera. The sample was alternatively subjected to scanning electron microscopic observation.ResultsCilia on the turbinate epithelium were well preserved at the ultrastructural level. The baseline ciliary beat frequency (CBF) was 6.45 ± 0.32 Hz. CBF was significantly increased by stimulation with 100 µM Ach and 100 µM adenosine triphosphate. The Ach-induced CBF increase was completely inhibited by removing extracellular Ca2+. Significant inhibition of the Ach-induced CBF was also observed by the addition of 1 µM atropine, 40 µM 2-aminoethoxydiphenyl borate (inositol trisphosphate [IP3] receptor antagonist), 10 µM carbenoxolone (pannexin-1 blocker), 1 mM probenecid (pannexin-1 blocker), 100 µM pyridoxalphosphate-6-azophenyl-20,40-disulfonic acid (P2X antagonist), and 300 µM flufenamic acid (connexin blocker). Meanwhile, 30 nM bafilomycin A1 (vesicular transport inhibitor) did not inhibit the Ach-induced CBF increase. Conclusions: These results indicate that the regulatory mechanism of the Ach-induced ciliary beat is dependent on extracellular Ca2+and involves the muscarinic Ach receptor, IP3receptor, pannexin-1 channel, purinergic P2X receptor, and connexin channel. We proposed a tentative intracellular signaling pathway of the Ach-induced ciliary beat, in which the pannexin-1-P2X unit may play a central role in ciliary beat regulation.

Published
2018

38. AMMA-CATCH, a critical zone observatory in West Africa monitoring a megion in transition

Author

Galle, Sylvie, Grippa, M., Bouzou Moussa, I., Cappelaere, B., Demarty, J., Mougin, E., Panthou, G., Adjomayi, P., Bâ, A., Boucher, M., Cohard, J, Descloitres, Marc, Descroix, Luc, Abdou, Malam, Malam-Issa, Oumarou, Agbossou, E., Cohard, M., 14, Sambou, Vouillamoz, J-M, Chazarin, J-P, 11, Mamane, Peugeot, C., Diawara, M., Dossou, M., Favreau, G., Gangneron, F., Gosset, M., Hector, B., Hiernaux, P., Issoufou, B., Kergoat, L., Lawin, E., Lebel, T., Legchenko, A., Malam-Issa, O., Mamadou, O., Nazoumou, Y., Pellarin, T., Quantin, G., Sambou, B., Seghieri, J., Seguis, L., Vandervaere, J., Vischel, T., Vouillamoz, M., Zannou, A., Afouda, S., Alhassane, A., Arjounin, M., Ba, H., Biron, R., Cazenave, F., Chaffard, V., Guyard, H., Koné, A., Mainassara, I., Mamane, A., Oi, M., Ouani, T., Soumaguel, N., Wubda, M., Ago, E., Alle, C., Allies, A., Arpin-Pont, F., Awessou, B., Cassé, C., Charvet, G., Dardel, C., Depeyre, A., Diallo, B., Do, T., Fatras, C., Frappart, F., Gal, L., Gascon, T., Gibon, F., Guiro, I., Ingatan, A., Kempf, J., Kotchoni, O., Lawson, M., Leauthaud, C., Louvet, S., Mason, E., Nguyen, C., Perrimond, B., Pierre, C., Richard, A., Robert, E., Román-Cascón, C., Velluet, C., Wilcox, C., Institut des Géosciences de l’Environnement (IGE), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Recherche pour le Développement (IRD)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Géosciences Environnement Toulouse (GET), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Météo France-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Abdou Moumouni [Niamey], Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'études spatiales de la biosphère (CESBIO), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France, Direction Générale de l'Eau, Université des sciences, des techniques et des technologies de Bamako, Université des sciences, des techniques et des technologies de Bamako (USTTB), Patrimoines Locaux et Gouvernance (PALOC), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD), Université de Zinder - University of Zinder [Zinder, Niger], IRD Représentation du Niger, Institut de Recherche pour le Développement (IRD), Laboratoire d'aérologie (LA), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Mécanismes et Transfert en Géologie (LMTG), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université A. Moumouni, HYBIS, Laboratoire d'étude des transferts en hydrologie et environnement (LTHE), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Civil Engineering Programme, University of KwaZulu-Natal (UKZN), Direction Générale de l'Eau (DGE), Ministère des Mines, de l'Energie et de l'Eau, Laboratoire d'étude des transferts en hydrologie et environnement, Université Joseph Fourier - Grenoble 1 (UJF)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD [Guinée]), Institut de Recherche pour le Développement, Observatoire AMMA-Catch (IRD), Observatoire AMMA-Catch, University of California [Los Angeles] (UCLA), University of California, ONERA - The French Aerospace Lab [Toulouse], ONERA, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Ecoclimasol, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), French Ministry of Research, OSUG, OREME, OMP, OSUG@2020 LabEx, SOERE RBV, CRITEX EquipEx [ANR-11-EQPX-0011], ANR: 11-EQPX-0011,CRITEX,Parc national d'équipements innovants pour l'étude spatiale et temporelle de la Zone Critique des Bassins Versants(2011), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Direction Générale de l'Eau [Bénin] (DGEau), Université d’Abomey-Calavi (UAC), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Laboratoire d'aérologie (LAERO), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Dan Dicko Dan koulodo de Maradi (UDDM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANR-11-EQPX-0011,CRITEX,Parc national d'équipements innovants pour l'étude spatiale et temporelle de la Zone Critique des Bassins Versants(2011), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Grenoble (INPG)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut d'Economie Rurale du Mali, Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Department of Applied Geophysics, Technische Universität Berlin (TUB)-Technische Universität Berlin (TUB), Institut de gestion des entreprises -USJ (IGE), Université Saint-Joseph de Beyrouth (USJ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de l'Environnement, Université du Québec à Chicoutimi (UQAC), Laboratoire d'étude des interactions entre sols, agrosystèmes et hydrosystèmes (LISAH), Institut National de la Recherche Agronomique (INRA), Département de Géographie, Université de Niamey, Geology Department, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), University of California (UC), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), and Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
CENTRAL SAHEL, 010504 meteorology & atmospheric sciences, 0208 environmental biotechnology, 02 engineering and technology, 01 natural sciences, Water balance, Démographie, 11. Sustainability, Water cycle, lcsh:Environmental sciences, Hydrologie, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, lcsh:GE1-350, Régime hydrique du sol, Utilisation des terres, CLIMATE-CHANGE, lcsh:QE1-996.5, GROSS PRIMARY PRODUCTION, Groundwater recharge, LAND-SURFACE, Geography, SEMIARNIGER, SATELLITE DATA, Ressource en eau, P40 - Météorologie et climatologie, Soil Science, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Context (language use), HARD-ROCK AQUIFERS, Monsoon, 12. Responsible consumption, SURFACE SOIL-MOISTURE, MONSOON MULTIDISCIPLINARY ANALYSIS, WATER STORAGE CHANGES, Mesure, Couverture végétale, P10 - Ressources en eau et leur gestion, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, 0105 earth and related environmental sciences, P36 - Érosion, conservation et récupération des sols, Changement climatique, Land use, Analyse de données, Global change, 15. Life on land, 020801 environmental engineering, lcsh:Geology, 13. Climate action, [SDU]Sciences of the Universe [physics], Climatologie, Physical geography, U30 - Méthodes de recherche, Surface runoff
Abstract

International audience; West Africa is a region in fast transition from climate, demography, and land use perspectives. In this context, the African Monsoon Multidisciplinary Analysis (AMMA)-Couplage de l'Atmosphere Tropicale et du Cycle eco-Hydrologique (CATCH) long-term regional observatory was developed to monitor the impacts of global change on the critical zone of West Africa and to better understand its current and future dynamics. The observatory is organized into three thematic axes, which drive the observation and instrumentation strategy: (i) analyze the long-term evolution of eco-hydrosystems from a regional perspective; (ii) better understand critical zone processes and their variability; and (iii) meet socioeconomic and development needs. To achieve these goals, the observatory has gathered data since 1990 from four densely instrumented mesoscale sites (similar to 10(4) km(2) each), located at different latitudes (Benin, Niger, Mali, and Senegal) so as to sample the sharp eco-climatic gradient that is characteristic of the region. Simultaneous monitoring of the vegetation cover and of various components of the water balance at these four sites has provided new insights into the seemingly paradoxical eco-hydrological changes observed in the Sahel during the last decades: groundwater recharge and/ or runoff intensification despite rainfall deficit and subsequent re-greening with still increasing runoff. Hydrological processes and the role of certain key landscape features are highlighted, as well as the importance of an appropriate description of soil and subsoil characteristics. Applications of these scientific results for sustainable development issues are proposed. Finally, detecting and attributing eco-hydrological changes and identifying possible regime shifts in the hydrologic cycle are the next challenges that need to be faced.

Published
2018
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40. Impact of anthropogenic activities and climate variability on the epidemiology of malaria and bilharziasis in Kaedi (Mauritania)

Author

Sidibé M, Dahdi S, Ba O, Kouadio K, Gbalegba G, Ba H, Kone B, and Chouaïbou M

Subjects
Global and Planetary Change, medicine.medical_specialty, Geography, Epidemiology, Health, Toxicology and Mutagenesis, Environmental health, Public Health, Environmental and Occupational Health, medicine, medicine.disease, Pollution, Malaria
Published
2019
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43. Pyridine-decorated carbon nanotubes as a metal-free heterogeneous catalyst for mild CO2reduction to methanol with hydroboranes

Author

Tuci G., Rossin A., Luconi L., Pham-Huu C., Cicchi S., Ba H., and Giambastiani G.

Abstract

© 2017 The Royal Society of Chemistry. Pyridine decorated multi-walled carbon nanotubes (N Py -MW) have been successfully employed as a catalyst for the reduction of carbon dioxide to methyl borinate (R 2 BO-CH 3 ) in the presence of 9-borabicyclo[3.3.1]nonane. N Py -MW represents the first example of a heterogeneous, metal-free and durable catalyst for CO 2 hydroboration to methanol. A mechanistic cycle has been proposed on the basis of targeted blank experiments and a quantum chemical study, highlighting the non-innocent role played by the nanotube carrier in the final N Py -MW catalytic performance.

Published
2017

44. Unraveling Surface Basicity and Bulk Morphology Relationship on Covalent Triazine Frameworks with Unique Catalytic and Gas Adsorption Properties

Author

Tuci G., Pilaski M., Ba H., Rossin A., Luconi L., Caporali S., Pham-Huu C., Palkovits R., and Giambastiani G.

Subjects
CO capture 2, metal-free catalysis, covalent triazine frameworks, steam-free ethylbenzene direct dehydrogenation, hydrogen storage
Abstract

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimActivity and selectivity are key features at the basis of an efficient catalytic system for promoting the steam- and oxygen-free dehydrogenation (DDH) of ethylbenzene to styrene. The catalyst stability under severe reaction conditions, the reduction of leaching of its active sites, and their resistance to deactivation phenomena on stream are other fundamental aspects to keep in mind while synthesizing new catalytic materials for the process. Although the recent use of single-phase (doped or undoped) carbon nanomaterials has significantly contributed to improving this catalysis, the relationship between materials morphology and their chemical surface properties still remains to be addressed. Here, a class of highly microporous, N-doped covalent triazine frameworks (CTFs) with superior activity and stability in the DDH compared to the benchmark systems of the state-of-the-art is reported. Notably, a comparative analysis of their chemico-physical properties has unveiled the role of the “chemically accessible” surface basicity on the catalyst passivation on stream. Finally, the unique properties of the synthesized CTFs are demonstrated by their excellent H2 storage capability and CO2 absorption that rank among the highest reported so far for related systems.

Published
2017

45. Macroscopically shaped monolith of nanodiamonds @ nitrogen-enriched mesoporous carbon decorated SiC as a superior metal-free catalyst for the styrene production

Author

Ba H., Luo J., Liu Y., Duong-Viet C., Tuci G., Giambastiani G., Nhut J., Nguyen-Dinh L., Ersen O., Su D., and Pham-Huu C.

Subjects
Direct dehydrogenation of ethylbenzene, Metal-free catalysis, Food-grade components, Macroscopically shaped monoliths, Nanodiamonds
Abstract

© 2016Nanodiamonds (NDs) are recognized as a class of robust metal-free catalysts for the steam-free, direct dehydrogenation (DDH) of ethylbenzene (EB) to styrene (ST). In spite of that, some main drawbacks, such as their powdery form along with their tendency to form aggregates, limit their full exploitation at the industrial level. In this work, we describe the preparation of macroscopically shaped monoliths consisting of silicon carbide-based foams coated with a nitrogen-rich mesoporous carbon matrix (NMC) as a non-innocent glue for highly dispersed ND fillers. The NMC phase is prepared from cheap and non-toxic food-grade components and it prevents the undesired NDs agglomeration thus maximizing the reagents exposure throughout the catalytic DDH tests. Moreover, the NMC phase represents a key source of surface basicity capable of inhibiting the occurrence of EB cracking side reactions during the catalytic runs. As a result, the ND@NMC/SiC composite shows excellent dehydrogenation performance already at low ND loading if compared with the powdery NDs and/or the SiC-supported NDs of the state-of-the-art. Noteworthy, the ND@NMC/SiC composite presents its best catalytic performance under DDH conditions close to those used in industrial plants (reaction temperture up to 600 °C and EB concentrations up to 10 vol.%) with high ST rates (λcatal. of 9.9 mmolST gcat−1 h−1), ST selectivity over 96% and long term stability on stream.

Published
2017

46. [Evaluation of malaria rapid diagnostic test Optimal-IT® pLDH along the Plasmodium falciparum distribution limit in Mauritania]

Author

Ba, H, Ahouidi, AD, Duffy, CW, Deh, YB, Diedhiou, C, Tandia, A, Diallo, MY, Assefa, S, Lô, BB, Elkory, MB, and Conway, DJ

Subjects
parasitic diseases
Abstract

Performance of the malaria Rapid Diagnostic Test (RDT) OptiMal-IT® was evaluated in Mauritania where malaria is low and dependent on a short transmission season. Slide microscopy was considered as the reference method of diagnosis. Febrile patients with suspected malaria were recruited from six health facilities, 3 urban and 3 rural, during two periods (December 2011 to February 2012, and August 2012 to March 2013). Overall, 780 patients were sampled, with RDT and thick blood film microscopy results being obtained for 759 of them. Out of 774 slides examined, of which 200 were positive, P. falciparum and P. vivax mono-infections were detected in 63.5% (127) and 29.5% (59), while P. falciparum/P. vivax coinfections were detected in 7% (14). Both species were observed in all study sites, although in significantly different proportions. The proportions of thick blood film and OptiMal-IT® RDT positive individuals was 26.3% and 30.3% respectively. Sensitivity and specificity of OptiMal-IT® RDT were 89% [95% CI, 84.7-93.3] and 91.1% [88.6-93.4]. Positives and negative predictive values were 78.1% [72.2-83.7] and 95.9% [94.1-97.5]. These diagnostic values are similar to those generally reported elsewhere, and support the use of RDTs as the main diagnostic tool for malaria in Mauritanian health facilities. In the future, choice of RDTs to be used must take account of thermostability in a hot, dry environment and their ability to detect P. falciparum and P. vivax.

Published
2016

47. Severe human illness caused by Rift Valley fever virus in Mauritania, 2015

Author

Boushab, B. M., Fall-Malick, F. Z., Baba, Sewo, Salem, M. L. O., Belizaire, M. R. D., Ledib, H., Ahmed, Mmob, Basco, Leonardo, and Ba, H.

Subjects
Assaba, Mauritania, Rift valley fever, Brakna, severe human illness
Abstract

Background. Rift Valley Fever epizootics are characterized by numerous abortions and mortality among young animals. In humans, the illness is usually characterized by a mild self-limited febrile illness, which could progress to more serious complications. Objectives. The aim of the present prospective study was to describe severe clinical signs and symptoms of Rift Valley Fever in southern Mauritania. Patients and methods. Suspected cases were enrolled in Kiffa (Assaba) and Aleg (Brakna) Hospital Centers from September 1 to November 7, 2015, based on the presence of fever, hemorrhagic or meningoencephalitic syndromes, and probable contact with sick animals. Suspected cases were confirmed by enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase-polymerase chain reaction (RT-PCR). Results. There were thirty-one confirmed cases. The sex ratio M/F and the average age were 2.9 and 25 years old [range, 4-70 years old], respectively. Mosquito bites, direct contact with aborted or dead animals, and frequent ingestion of milk from these animals were risk factors observed in all patients. Hemorrhagic and neurological manifestations were observed in 81% and 13% of cases, respectively. The results of laboratory analysis showed high levels of transaminases, creatinine, and urea associated with thrombocytopenia, anemia, and leukopenia. All patients who died (42%) had a hemorrhagic syndrome and 3 of them had a neurological complication. Among the cured patients, none had neurologic sequelae. Conclusion. The hemorrhagic form was the most common clinical manifestation of RVF found in southern Mauritania and was responsible for a high mortality rate. Our results justify the implementation of a continuous epidemiological surveillance.

Published
2016

48. N-Doped Food-Grade-Derived 3D Mesoporous Foams as Metal-Free Systems for Catalysis

Author

Ba H., Liu Y., Truong-Phuoc L., Duong-Viet C., Nhut J., Nguyen D., Ersen O., Tuci G., Giambastiani G., and Pham-Huu C.

Subjects
oxygen reduction reaction, nitrogen-doped carbon composites, metal-free catalysts, steam-free ethylbenzene direct dehydrogenation, 3D shaped mesoporous materials
Abstract

© 2016 American Chemical Society.A challenging task of modern and sustainable catalysis is to rethink key processes at the heart of renewable energy technology in light of metal-free catalytic architectures designed and fabricated from cheap and easily accessible building blocks. This contribution describes the synthesis of highly N doped, carbon nanotube (CNT)-netting composites from cheap raw materials. With physical mixtures of CNTs and food-grade components as the starting materials, their thermal treatment generates foamy, N-doped carbon-based architectures. The mesoporous nature of the N-doped carbon phase grown around intertwined carbon nanotube networks and the easy control of the final material 3D shape make the protocol highly versatile for its full exploitation in the production of materials for catalysis. In addition to offering unique advantages with respect to the classical N-doped CNT powders, the 3D metal-free composites are highly versatile systems for a number of liquid-phase and gas-phase catalytic processes, under a wide operative temperature range. In this paper we demonstrate their excellent and to some extent unique catalytic performance in two fundamental and catalyst-demanding processes: (i) the electrochemical oxygen reduction reaction (ORR) and (ii) the direct, steam-free dehydrogenation of ethylbenzene (EB) to styrene (ST).

Published
2016

50. A highly N-doped carbon phase 'dressing' of macroscopic supports for catalytic applications

Author

Ba H., Liu Y., Truong-Phuoc L., Duong-Viet C., Mu X., Doh W., Tran-Thanh T., Baaziz W., Nguyen-Dinh L., Nhut J., Janowska I., Begin D., Zafeiratos S., Granger P., Tuci G., Giambastiani G., Banhart F., Ledoux M., and Pham-Huu C.

Abstract

© The Royal Society of Chemistry 2015. The straightforward "dressing" of macroscopically shaped supports (i.e. β-SiC and α-Al2O3) with a mesoporous and highly nitrogen-doped carbon-phase starting from food-processing raw materials is described. The as-prepared composites serve as highly efficient and selective metal-free catalysts for promoting industrial key-processes at the heart of renewable energy technology and environmental protection.

Published
2015

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