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5. Figure S3 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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6. Data from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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7. Supplementary Table 2 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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8. Supplementary Table 1 from Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, primary, Verginadis, Ioannis I., primary, Morcos, George, primary, Loo, Phoebe E., primary, Kim, Michele M., primary, Motlagh, Seyyedeh Azar Oliaei, primary, Shoniyozov, Khayrullo, primary, Diffenderfer, Eric S., primary, Ocampo, Emilio A., primary, Putt, Mary, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Lu, Jiawei, primary, Qin, Ling, primary, Liu, Hengxi, primary, Leli, Nektaria Maria, primary, Girdhani, Swati, primary, Denef, Nicolas, primary, Vander Stappen, Francois, primary, Cengel, Keith A., primary, Busch, Theresa M., primary, Metz, James M., primary, Dong, Lei, primary, Lin, Alexander, primary, and Koumenis, Constantinos, primary

Published
2024
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11. Proton FLASH radiotherapy ameliorates radiation-induced salivary gland dysfunction and oral mucositis and increases survival in a mouse model of head and neck cancer

Author

Chowdhury, Priyanka, primary, Velalopoulou, Anastasia, additional, Verginadis, Ioannis I., additional, Morcos, George, additional, Loo, Phoebe E., additional, Kim, Michele M., additional, Motlagh, Seyyedeh Azar Oliaei, additional, Shoniyozov, Khayrullo, additional, Diffenderfer, Eric S., additional, Ocampo, Emilio A., additional, Putt, Mary, additional, Assenmacher, Charles-Antoine, additional, Radaelli, Enrico, additional, Lu, Jiawei, additional, Qin, Ling, additional, Liu, Hengxi, additional, Leli, Nektaria Maria, additional, Girdhani, Swati, additional, Denef, Nicolas, additional, Vander Stappen, Francois, additional, Cengel, Keith A., additional, Busch, Theresa M., additional, Metz, James M., additional, Dong, Lei, additional, Lin, Alexander, additional, and Koumenis, Constantinos, additional

Published
2024
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14. Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

Author

Diffenderfer, Eric S., Verginadis, Ioannis I., Kim, Michele M., Shoniyozov, Khayrullo, Velalopoulou, Anastasia, Goia, Denisa, Putt, Mary, Hagan, Sarah, Avery, Stephen, Teo, Kevin, Zou, Wei, Lin, Alexander, Swisher-McClure, Samuel, Koch, Cameron, Kennedy, Ann R., Minn, Andy, Maity, Amit, Busch, Theresa M., Dong, Lei, Koumenis, Costas, Metz, James, and Cengel, Keith A.

Published
2020
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17. Supplementary Figure 5 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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18. Supplementary Figure 1 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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19. FIGURE 3 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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20. Supplementary Figure 2 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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21. Supplementary Figure 3 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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22. FIGURE 7 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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23. FIGURE 6 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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24. FIGURE 5 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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25. Supplementary Figure 4 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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27. FIGURE 1 from Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W., primary, Klampatsa, Astero, primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Miller, Joann M., primary, Yuan, Min, primary, Houser, Cassandra, primary, Snyder, Emma, primary, Putt, Mary, primary, Vinogradov, Sergei A., primary, Albelda, Steven M., primary, Cengel, Keith A., primary, and Busch, Theresa M., primary

Published
2023
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30. Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy

Author

Davis, Richard W, primary, Klampatsa, Astero, additional, Cramer, Gwendolyn M, additional, Kim, Michele M., additional, Miller, Joann M, additional, Yuan, Min, additional, Houser, Cassandra, additional, Snyder, Emma, additional, Putt, Mary, additional, Vinogradov, Sergei A, additional, Albelda, Steven M., additional, Cengel, Keith A, additional, and Busch, Theresa M, additional

Published
2023
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31. Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.

Author

Hongjing Sun, Yihong Ong, Weibing Yang, Sourvanos, Dennis, Dimofte, Andreea, Busch, Theresa M., Singhal, Sunil, Cengel, Keith A., and Zhu, Timothy C.

Subjects
MEDICAL dosimetry, PHOTODYNAMIC therapy, PHOTOMETRY, TREATMENT effectiveness, CANCER treatment, THERMOLUMINESCENCE dosimetry
Abstract

Significance: Photodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce an innovative eight-channel PDT dose dosimetry system capable of concurrently measuring light fluence and PS concentration during treatment. Aim: We aim to develop and evaluate an eight-channel PDT dose dosimetry system for simultaneous measurement of light fluence and PS concentration. By addressing uncertainties due to tissue variations, the system enhances accurate PDT dosimetry for improved treatment outcomes. Approach: The study positions eight isotropic detectors strategically within the pleural cavity before PDT. These detectors are linked to bifurcated fibers, distributing signals to both a photodiode and a spectrometer. Calibration techniques are applied to counter tissue-related variations and improve measurement accuracy. The fluorescence signal is normalized using the measured light fluence, compensating for variations in tissue properties. Measurements were taken in 78 sites in the pleural cavities of 20 patients. Results: Observations reveal minimal Photofrin concentration variation during PDT at each site, juxtaposed with significant intra- and inter-patient heterogeneities. Across 78 treated sites in 20 patients, the average Photofrin concentration for all 78 sites is 4.98 µM, with a median concentration of 4.47 µM. The average PDT dose for all 78 sites is 493.17 µMJ/cm², with a median dose of 442.79 µMJ/cm². A significant variation in PDT doses is observed, with a maximum difference of 3.1 times among all sites within one patient and a maximum difference of 9.8 times across all patients. Conclusions: The introduced eight-channel PDT dose dosimetry system serves as a valuable real-time monitoring tool for light fluence and PS concentration during PDT. Its ability to mitigate uncertainties arising from tissue properties enhances dosimetry accuracy, thus optimizing treatment outcomes and bolstering the effectiveness of PDT in cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Fractionated Photofrin-Mediated Photodynamic Therapy Significantly Improves Long-Term Survival.

Author

Sun, Hongjing, Yang, Weibing, Ong, Yihong, Busch, Theresa M., and Zhu, Timothy C.

Subjects
PORPHYRINS, BIOLOGICAL models, INTRAVENOUS therapy, PHOTODYNAMIC therapy, ANIMAL experimentation, PHOTOSENSITIZERS, TREATMENT duration, TREATMENT effectiveness, COMPARATIVE studies, DESCRIPTIVE statistics, RESEARCH funding, TUMORS, RADIATION carcinogenesis, REACTIVE oxygen species, MICE, RADIATION dosimetry, EVALUATION
Abstract

Simple Summary: We have demonstrated that a fractionated PDT scheme, delivered using a two-hour interval between two light delivery treatments, significantly improves long-term efficacy of Photofrin-mediated PDT while reducing side effects. Reactive Oxygen Species Explicit Dosimetry (ROSED), utilizing direct measurements of in vivo light fluence, in vivo Photofrin concentration, and in vivo tissue oxygenation concentration, were used to determine the concentration of reacted reactive oxygen species, [ROS]rx, as a dosimetry quantity for PDT treatment. We found that a threshold Photofrin dose of 0.78 mM is required for the complete cure (90-day survival) of RIF tumors using fractionated Photofrin-mediated PDT treatment. To our knowledge, this is the first report of this parameter. This study investigates the effect of fractionated (two-part) PDT on the long-term local control rate (LCR) using the concentration of reactive oxygen species ([ROS]rx) as a dosimetry quantity. Groups with different fractionation schemes are examined, including a 2 h interval between light delivery sessions to cumulative fluences of 135, 180, and 225 J/cm2. While the total treatment time remains constant within each group, the division of treatment time between the first and second fractionations are explored to assess the impact on long-term survival at 90 days. In all preclinical studies, Photofrin is intravenously administered to mice at a concentration of 5 mg/kg, with an incubation period between 18 and 24 h before the first light delivery session. Fluence rate is fixed at 75 mW/cm2. Treatment ensues via a collimated laser beam, 1 cm in diameter, emitting light at 630 nm. Dosimetric quantities are assessed for all groups along with long-term (90 days) treatment outcomes. This study demonstrated a significant improvement in long-term survival after fractionated treatment schemes compared to single-fraction treatment, with the optimal 90-day survival increasing to 63%, 86%, and 100% vs. 20%, 25%, and 50%, respectively, for the three cumulative fluences. The threshold [ROS]rx for the optimal scheme of fractionated Photofrin-mediated PDT, set at 0.78 mM, is significantly lower than that for the single-fraction PDT, at 1.08 mM. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Data from The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

Author

Cerniglia, George J., primary, Dey, Souvik, primary, Gallagher-Colombo, Shannon M., primary, Daurio, Natalie A., primary, Tuttle, Stephen, primary, Busch, Theresa M., primary, Lin, Alexander, primary, Sun, Ramon, primary, Esipova, Tatiana V., primary, Vinogradov, Sergei A., primary, Denko, Nicholas, primary, Koumenis, Constantinos, primary, and Maity, Amit, primary

Published
2023
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35. Supplementary Figures 1-9; Supplementary Table 1 from The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

Author

Cerniglia, George J., primary, Dey, Souvik, primary, Gallagher-Colombo, Shannon M., primary, Daurio, Natalie A., primary, Tuttle, Stephen, primary, Busch, Theresa M., primary, Lin, Alexander, primary, Sun, Ramon, primary, Esipova, Tatiana V., primary, Vinogradov, Sergei A., primary, Denko, Nicholas, primary, Koumenis, Constantinos, primary, and Maity, Amit, primary

Published
2023
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37. Figure SF6 from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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38. Table ST1 from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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44. Supplemental Methods from FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Author

Velalopoulou, Anastasia, primary, Karagounis, Ilias V., primary, Cramer, Gwendolyn M., primary, Kim, Michele M., primary, Skoufos, Giorgos, primary, Goia, Denisa, primary, Hagan, Sarah, primary, Verginadis, Ioannis I., primary, Shoniyozov, Khayrullo, primary, Chiango, June, primary, Cerullo, Michelle, primary, Varner, Kelley, primary, Yao, Lutian, primary, Qin, Ling, primary, Hatzigeorgiou, Artemis G., primary, Minn, Andy J., primary, Putt, Mary, primary, Lanza, Matthew, primary, Assenmacher, Charles-Antoine, primary, Radaelli, Enrico, primary, Huck, Jennifer, primary, Diffenderfer, Eric, primary, Dong, Lei, primary, Metz, James, primary, Koumenis, Constantinos, primary, Cengel, Keith A., primary, Maity, Amit, primary, and Busch, Theresa M., primary

Published
2023
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50. A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply

Author

Zou, Wei, primary, Kim, Haram, additional, Diffenderfer, Eric S., additional, Carlson, David J., additional, Koch, Cameron J., additional, Xiao, Ying, additional, Teo, BoonKeng K., additional, Kim, Michele M., additional, Metz, James M., additional, Fan, Yi, additional, Maity, Amit, additional, Koumenis, Costas, additional, Busch, Theresa M., additional, Wiersma, Rodney, additional, Cengel, Keith A., additional, and Dong, Lei, additional

Published
2022
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