73 results on '"BULLÓ BONET, MÒNICA'
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2. Nutrició en l’esport: pràctica, dieta, suplementació esportiva i relació amb la dieta i imatge corporal
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Bulló Bonet, Mònica, Bisellach Martínez, Iñaki, Bulló Bonet, Mònica, and Bisellach Martínez, Iñaki
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- 2023
3. Millora del rendiment esportiu a través del consum del remolatxa en esportistes: Una revisió sistemàtica.
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Bulló Bonet, Mònica, Guillen Peña, Albert, Bulló Bonet, Mònica, and Guillen Peña, Albert
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- 2022
4. Avaluació del patró de consum de Creatina, Omega - 3, BCAA's i Glutamina en forma de suplementació, i l'adequació d'aquest a l'evidència cietífica actual en esportistes de força amateurs
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Bulló Bonet, Mònica, Hermoso Arboix, Oriol, Bulló Bonet, Mònica, and Hermoso Arboix, Oriol
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- 2022
5. Guia nutricional per a la síndrome d’ovari poliquístic amb evidències sobre les malalties amb més risc: Una revisió narrativa
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Bulló Bonet, Mònica, Gay Sentís, Gisela, Bulló Bonet, Mònica, and Gay Sentís, Gisela
- Published
- 2021
6. Estudi sobre l'ús de suplementació nutricional esportiva en els estudiants d'universitats catalanes
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Bulló Bonet, Mònica, Sans Ribas, Roger, Bulló Bonet, Mònica, and Sans Ribas, Roger
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- 2021
7. ¿Qué tipo de suplemento proteico es óptimo para la mejora del rendimiento deportivo? una revisión sistemática de ensayos clínicos aleatorizados
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Bulló Bonet, Mònica, Carvajal Abellán, Noelia, Bulló Bonet, Mònica, and Carvajal Abellán, Noelia
- Published
- 2021
8. Anexo 4 - Tabla de índice glucémico
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Bulló i Bonet, Mònica
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- 2019
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- View/download PDF
9. Micronutrientes en la infección por el virus de la inmunodeficiencia humana y su relación con la respuesta inflamatoria
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Jesúes Jiménez-Expósito, María, Bulló Bonet, Mònica, Alonso-Villaverde, Carlos, Serrano, Pilar, García-Lorda, Pilar, García-Luna, Pedro Pablo, Masana, Lluís, and Salas-Salvadó, Jordi
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- 2002
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10. Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation
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BULLÓ BONET, MÒNICA, Pérez-Martínez, P., Mikhailidis, DP., Athyros, VG., Couture, P., Covas, MI., de Koning, L., Delgado-Lista, J., Díaz-López, A., Drevon, CA., Estruch, R., Esposito, K., Fitó, M., Garaulet, M., Giugliano, D., García-Ríos, A., Katsiki, N., Kolovou, G., Lamarche, B., Maiorino, MI., Mena-Sánchez, G., Muñoz-Garach, A., Nikolic, D., Ordovás, JM., Pérez-Jiménez, F., Rizzo, M., SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Ciències de la salut ,0029-6643 ,Health sciences ,METABOLISME TRASTORNS ,DIETOTERÀPIA ,Dietary patterns ,Lifestyle ,Ciencias de la salud ,metabolic syndrome - Abstract
The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the available scientific evidence on the associations between lifestyle changes and MetS and its components is reviewed to derive recommendations for MetS prevention and management. Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS. A Mediterranean-type diet, with or without energy restriction, is an effective treatment component. This dietary pattern should be built upon an increased intake of unsaturated fat, primarily from olive oil, and emphasize the consumption of legumes, cereals (whole grains), fruits, vegetables, nuts, fish, and low-fat dairy products, as well as moderate consumption of alcohol. Other dietary patterns (Dietary Approaches to Stop Hypertension, new Nordic, and vegetarian diets) have also been proposed as alternatives for preventing MetS. Quitting smoking and reducing intake of sugar-sweetened beverages and meat and meat products are mandatory. Nevertheless, there are inconsistencies and gaps in the evidence, and additional research is needed to define the most appropriate therapies for MetS. In conclusion, a healthy lifestyle is critical to prevent or delay the onset of MetS in susceptible individuals and to prevent cardiovascular disease and type 2 diabetes in those with existing MetS. The recommendations provided in this article should help patients and clinicians understand and implement the most effective approaches for lifestyle change to prevent MetS and improve cardiometabolic health.
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- 2017
11. The effect of a mediterranean diet on the incidence of cataract surgery
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BULLÓ BONET, MÒNICA, García-Layana, A., Ciufo, G., Toledo, E., Martínez-González, M.A., Corella, D., Fitó, M., Estruch, R., Gómez-Gracia, E., Fiol, M., Lapetra, J., Serra-Majem, L., Pintó, X., Portillo, M.P., Sorli, J.V., Vinyoles, E., Sala-Vila, A., Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Biochemistry and technology ,Bioquímica y tecnología ,cataract ,Cataractes -- Cirurgia ,nuts ,Bioquímica i biotecnologia ,2072-6643 ,Dieta mediterrània ,Antioxidants - Abstract
DOI: 10.3390/nu9050453 http://www.mdpi.com/2072-6643/9/5/453 Filiació URV: SI Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55–80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted
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- 2017
- Full Text
- View/download PDF
12. Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; Pérez-Martínez, P.; Mikhailidis, DP.; Athyros, VG.; Couture, P.; Covas, MI.; de Koning, L.; Delgado-Lista, J.; Díaz-López, A.; Drevon, CA.; Estruch, R.; Esposito, K.; Fitó, M.; Garaulet, M.; Giugliano, D.; García-Ríos, A.; Katsiki, N.; Kolovou, G.; Lamarche, B.; Maiorino, MI.; Mena-Sánchez, G.; Muñoz-Garach, A.; Nikolic, D.; Ordovás, JM.; Pérez-Jiménez, F.; Rizzo, M.; SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; Pérez-Martínez, P.; Mikhailidis, DP.; Athyros, VG.; Couture, P.; Covas, MI.; de Koning, L.; Delgado-Lista, J.; Díaz-López, A.; Drevon, CA.; Estruch, R.; Esposito, K.; Fitó, M.; Garaulet, M.; Giugliano, D.; García-Ríos, A.; Katsiki, N.; Kolovou, G.; Lamarche, B.; Maiorino, MI.; Mena-Sánchez, G.; Muñoz-Garach, A.; Nikolic, D.; Ordovás, JM.; Pérez-Jiménez, F.; Rizzo, M.; SALAS SALVADÓ, JORGE
- Abstract
The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the available scientific evidence on the associations between lifestyle changes and MetS and its components is reviewed to derive recommendations for MetS prevention and management. Weight loss through an energy-restricted diet together with increased energy expenditure through physical activity contribute to the prevention and treatment of MetS. A Mediterranean-type diet, with or without energy restriction, is an effective treatment component. This dietary pattern should be built upon an increased intake of unsaturated fat, primarily from olive oil, and emphasize the consumption of legumes, cereals (whole grains), fruits, vegetables, nuts, fish, and low-fat dairy products, as well as moderate consumption of alcohol. Other dietary patterns (Dietary Approaches to Stop Hypertension, new Nordic, and vegetarian diets) have also been proposed as alternatives for preventing MetS. Quitting smoking and reducing intake of sugar-sweetened beverages and meat and meat products are mandatory. Nevertheless, there are inconsistencies and gaps in the evidence, and additional research is needed to define the most appropriate therapies for MetS. In conclusion, a healthy lifestyle is critical to prevent or delay the onset of MetS in susceptible individuals and to prevent cardiovascular disease and type 2 diabetes in those with existing MetS. The recommendations provided in this article should help patients and clinicians understand and implement the most effective approaches for lifestyle change to prevent MetS and improve cardiometabolic health.
- Published
- 2017
13. The effect of a mediterranean diet on the incidence of cataract surgery
- Author
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; García-Layana, A. ; Ciufo, G. ; Toledo, E. ; Martínez-González, M.A. ; Corella, D. ; Fitó, M. ; Estruch, R. ; Gómez-Gracia, E.; Fiol, M.; Lapetra, J.; Serra-Majem, L.; Pintó, X.; Portillo, M.P.; Sorli, J.V.; Vinyoles, E.; Sala-Vila, A., Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; García-Layana, A. ; Ciufo, G. ; Toledo, E. ; Martínez-González, M.A. ; Corella, D. ; Fitó, M. ; Estruch, R. ; Gómez-Gracia, E.; Fiol, M.; Lapetra, J.; Serra-Majem, L.; Pintó, X.; Portillo, M.P.; Sorli, J.V.; Vinyoles, E.; Sala-Vila, A.
- Abstract
DOI: 10.3390/nu9050453 http://www.mdpi.com/2072-6643/9/5/453 Filiació URV: SI, Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55–80 years) from the Prevención con Dieta Mediterránea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted
- Published
- 2017
14. Effect of a diet on healthy food or a Mediterranean diet on change in the composition and function of faecal microbiota
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Bulló Bonet, Mònica, primary
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- 2017
- Full Text
- View/download PDF
15. Resultats preliminars estudi Satin
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Bulló Bonet, Mònica, Capdevila Solé, Maria; López Arronis, Cristina, Bulló Bonet, Mònica, and Capdevila Solé, Maria; López Arronis, Cristina
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- 2016
16. EFECTOS DEL CONSEJO NUTRICIONAL SOBRE LOS HÁBITOS ALIMENTARIOS EN DEPORTISTAS
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Bulló Bonet, Mònica, Martín Fernández Annabel ; Jiménez Triguero Luís, Bulló Bonet, Mònica, and Martín Fernández Annabel ; Jiménez Triguero Luís
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- 2016
17. Micronutrientes en la infección por el virus de la inmunodeficiencia humana y su relación con la respuesta inflamatoria
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Jordi Salas-Salvadó, Mònica Bulló Bonet, Lluís Masana, María Jesúes Jiménez-Expósito, Pilar García-Lorda, Pilar Serrano, Pedro Pablo García-Luna, and Carlos Alonso-Villaverde
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business.industry ,Inflammatory response ,Medicine ,General Medicine ,Respuesta inflamatoria ,business ,Humanities - Abstract
Fundamento Describir las concentraciones sericas de ciertas vitaminas y micronutrientes relacionadoscon la respuesta inmunitaria y el sistema antioxidante, en una poblacion de individuoscon infeccion por el virus de la inmunodeficiencia humana (VIH) y determinar su relacioncon la respuesta inflamatoria. Pacientes y metodo Se incluyo a 86 individuos con infeccion por el VIH documentada; divididosen tres grupos (VIH-positivos asintomaticos; sida sin infeccion oportunista y sida con infeccionoportunista activa), que fueron comparados con un grupo control. Se determinaron los valoresplasmaticos de vitamina A, vitamina E, cobre y cinc, asi como parametros inflamatorios. En todoslos pacientes se realizaron pruebas de absorcion de grasas e hidratos de carbono. Resultados Se detectaron valores inferiores a los intervalos de referencia de vitamina A y E enel 36,4 y el 14,3% de los pacientes, respectivamente, y en ninguno de los controles. La prevalenciadel deficit de vitamina A aumento con la gravedad de la enfermedad. La prevalencia depacientes con concentraciones de cobre por debajo de los intervalos de referencia fue inferior ala de los sujetos controles. Los individuos con sida e infeccion oportunista activa presentaronconcentraciones de vitamina A significativamente inferiores (p Conclusiones Los deficit de micronutrientes son prevalentes en individuos con infeccion por elVIH desde estadios iniciales de la enfermedad. La disminucion de la vitamina A y el aumentodel cobre se correlacionan significativamente con parametros inflamatorios, lo que sugiere quesus concentraciones plasmaticas podrian responder mas a la situacion de inflamacion que alpropio estado nutricional.
- Published
- 2002
18. Effect of nut consumption on semen quality and functionality in healthy males
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Bulló Bonet, Mònica, primary
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- 2016
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19. Consenso sobre las grasas y aceites en la alimentación de la población española adulta: postura de la Federación Española de Sociedades de Alimentación, Nutrición y Dietética (FESNAD)
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Universitat Rovira i Virgili, Emilio Ros Rahola; José López Miranda; Catalina Picó Segura; Miguel Angel Rubio Herrera; Nancy Babio; Aleix Sala Vila; Francisco Pérez Jiménez; Eduard Escrich; Mònica Bulló Bonet; Montserrat Solanas i García; Angel Gil Hernández; Jordi Salas Salvadó, Universitat Rovira i Virgili, and Emilio Ros Rahola; José López Miranda; Catalina Picó Segura; Miguel Angel Rubio Herrera; Nancy Babio; Aleix Sala Vila; Francisco Pérez Jiménez; Eduard Escrich; Mònica Bulló Bonet; Montserrat Solanas i García; Angel Gil Hernández; Jordi Salas Salvadó
- Abstract
La calidad de la grasa dietética tiene una profunda influencia sobre la salud. En este documento de consenso se evalúa la evidencia científica relativa a los efectos de la cantidad y calidad de la grasa alimentaria sobre la salud cardiovascular y se emiten recomendaciones para la población española adulta. Como novedad en unas guías nutricionales, se hace menos hincapié en los ácidos grasos per se que en los alimentos que los contienen. En resumen, sustituir ácidos grasos saturados (AGS) por monoinsaturados (AGM) y poliinsaturados (AGP) reduce el riesgo cardiovascular. Datos recientes sugieren que la ingesta de AGS per se es nociva solo en función del alimento que los contiene, por lo que no parece oportuno establecer un umbral de ingesta, pero se desaconsejan alimentos que los contienen en exceso, como la mantequilla y algunos derivados cárnicos, bollería y fritos comerciales. El límite de
- Published
- 2015
20. FABP4 predicts atherogenic dyslipidemia development. The PREDIMED study
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BABIO SÁNCHEZ, NANCY ELVIRA, Anna Cabré, Iolanda Lázaro, BULLÓ BONET, MÒNICA, Ana Garcia-Arellano, Lluís Masana, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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PREDIMED ,Biochemistry and technology ,Bioquímica y tecnología ,0021-9150 ,FABP4 ,Àcids grassos -- Metabolisme ,Lípids--Metabolisme--Trastorns ,Atherogenic dyslipidemia ,Bioquímica i biotecnologia ,Dieta mediterrània - Abstract
Filiació URV: SI OBJECTIVE: Atherogenic dyslipidemia (AD), characterized by high plasma triglycerides and low HDL particles, is considered one of the main effectors of vascular damage associated with obesity, metabolic syndrome (MS) and type 2 diabetes. Adipocyte fatty acid-binding protein (FABP4) plasma concentrations have been linked to metabolic alterations that are associated with adiposity. The aim of the present study was to prospectively analyze the predictive value of baseline FABP4 plasma concentrations for the development of AD. METHODS: In the frame of the PREDIMED study, a multicenter dietary interventional trial, we prospectively measured the baseline plasma FABP4 levels and AD incidence over a six-year follow-up period (median 4 [IQR, 3-5 years]) in 578 volunteers who visited their general practitioners because of their cardiovascular risk factors. RESULTS: During follow-up, 103 participants developed AD. Baseline plasma FABP4 levels were associated with new onset AD over the follow-up period (OR 1.03 [95% IC: 1.00-1.05], p=0.020). This increased risk was observed in women but not in men. Among women, those in the highest tertile of FABP4 had a 2.54-fold increased relative risk of developing AD compared to the lowest tertile (HR 2.54 [95% CI, 1.31-4.93], p for trend=0.008). CONCLUSIONS: Elevated plasma FABP4 concentrations should be considered as a potential marker of metabolic derangement, which may predict the development of AD in women.
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- 2012
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21. Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women
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BULLÓ BONET, MÒNICA, R. Estruch, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
- Subjects
PREDIMED ,Biochemistry and technology ,Bioquímica y tecnología ,Vitamin K ,8756-3282 ,Bone metabolism ,Ossos -- Metabolisme ,Bioquímica i biotecnologia ,Vitamines K ,Dieta mediterrània - Abstract
BACKGROUND: Vitamin K may have a protective role against bone loss and osteoporotic fractures associated to aging, although data in humans are inconsistent and the mechanisms involved are still unknown. The main objective of the study was to assess the associations between vitamin K intake, bone density, bone structure quality and biochemical bone metabolism markers in elderly subjects. We also analyzed the relationship between changes in vitamin K intake and the evolution of bone quality markers after two years of follow-up. METHODS: Cross-sectional analysis was carried out on 365 elderly subjects, 200 of whom were also included in a 2-year longitudinal follow-up study. Usual dietary intakes were assessed using a semi-quantitative 137-item food frequency questionnaire (FFQ). Vitamin K intake was estimated using the USDA database. Bone biochemical markers were measured in a subset of 125 subjects. Quantitative ultrasound assessment (QUS) was performed at the calcaneus to estimate bone mineral density (BMD), speed of sound (SOS), broadband ultrasound attenuation (BUA) and the quantitative ultrasound index (QUI). RESULTS: Dietary intake of vitamin K was significantly associated with higher BMD and better QUS. No significant associations were found between vitamin K intake and bone biochemical markers. Those subjects who increased their vitamin K intake showed a lower loss of BMD, a lower decrease in SOS and a nonsignificant increase in BUA. CONCLUSIONS: High dietary vitamin K intake was associated with superior bone properties. Moreover, an increase in dietary vitamin K was significantly related to lower losses of bone mineral density and smaller increases in the porosity and elasticity attributed to aging, which helps to explain the previously described prot
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- 2011
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22. Bone quantitative ultrasound measurements in relation to the metabolic syndrome and type 2 diabetes mellitus in a cohort of elderly subjects at high risk of cardiovascular disease from the PREDIMED study
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BULLÓ BONET, MÒNICA, M. GARCIA-ALOY, J. BASORA, M.I. COVAS, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Bone health ,Biochemistry and technology ,Ossos--Metabolisme ,Síndrome metabòlica ,Bioquímica y tecnología ,type 2 diabetes mellitus ,Bioquímica i biotecnologia ,Diabetis no-insulinodependent ,metabolic syndrome ,1279-7707 - Abstract
OBJECTIVE: The aim of this study is to determine whether metabolic syndrome, its individual components, or the presence of type 2 diabetes mellitus are associated with a better bone status estimated by quantitative ultrasound at the calcaneus. DESIGN: Cross-sectional study. SETTING: Outpatient clinics. PARTICIPANTS: 251 elderly subjects at high cardiovascular risk from the PREDIMED study were included. MEASUREMENTS: MetS was defined according to the ATPIII diagnosis criteria. Calcaneus quantitative ultrasound (QUS) assessment was performed using the Sahara system. RESULTS: Subjects with MetS showed significantly lower 24-hour urinary deoxypyridinoline/creatinine (u-DPD/creatinine) levels and higher broadband ultrasound attenuation, and a tendency to higher bone mineral density (BMD) and quantitative ultrasound index (QUI) than their counterparts. Individuals with type 2 diabetes mellitus (T2DM) showed a significantly higher bone broadband ultrasound attenuation (BUA) and QUI than their non-diabetic counterparts, despite they shown a higher prevalence of osteoporotic fractures. Multiple linear regression analyses showed that quantitative ultrasound parameters were positively associated with the metabolic syndrome and T2DM. Of the bone biochemical markers, only u-DPD/creatinine was related to MetS, abdominal obesity, hypertriglyceridemia component of the MetS, and the number of features that define the MetS. CONCLUSION: This is the first study showing a positive association between MetS or T2DM with better bone status and lower bone resorption markers measured by quantitative ultrasound. Our results suggest that metabolic abnormalities have a positive effect on healthy bone in elderly subjects at high risk of cardiovascular disease.
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- 2011
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23. Mediterranean diet and oxidation: nuts and olive oil as important sources of fat and antioxidants
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BULLÓ BONET, MÒNICA, Rosa Lamuela-Raventós, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Oli d'oliva ,Biochemistry and technology ,Bioquímica y tecnología ,virgin olive oil ,Estrès oxidatiu ,oxidative stress ,nuts ,1568-0266 ,Bioquímica i biotecnologia ,Nous - Abstract
Oxidative stress has been involved in the aetiology of hypertension, insulin resistance, the metabolic syndrome, cardiovascular disease and other chronic conditions. Several epidemiological studies suggest that a diet rich in natural antioxidants is associated with protective effects against major diseases, especially cardiovascular disease. The Mediterranean diet is rich in fat and foods with important antioxidant properties, such as fruits and vegetables, olive oil, and nuts. In this review we focus on epidemiological evidence and clinical trials that relate the Mediterranean diet with oxidative stress markers. We focus our review on two important Mediterranean vegetable sources of potentially oxidized fat-olive oil and nuts.
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- 2011
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24. Dietary intake of vitamin K is inversely associated with mortality risk
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Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Ruiz-Gutierrez, V, Munoz, MA, Pinto, X, Serra-Majem, L, Lamuela-Raventós, RM, Basora, J, Lapetra, J, Fiol, M, Gomez-Gracia, E, Fito, M, Ros, E, Estruch, R, Corella, D, Martinez-Gonzalez, MA, SALAS SALVADÓ, JORGE, Juanola-Falgarona, M, FERNÁNDEZ BALLART, JOAN DOMÈNECH, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Ruiz-Gutierrez, V, Munoz, MA, Pinto, X, Serra-Majem, L, Lamuela-Raventós, RM, Basora, J, Lapetra, J, Fiol, M, Gomez-Gracia, E, Fito, M, Ros, E, Estruch, R, Corella, D, Martinez-Gonzalez, MA, SALAS SALVADÓ, JORGE, Juanola-Falgarona, M, FERNÁNDEZ BALLART, JOAN DOMÈNECH, and BULLÓ BONET, MÒNICA
- Abstract
Vitamin K has been related to cardiovascular disease and cancer risk. However, data on total mortality are scarce. The aim of the present study was to assess the association between the dietary intake of different types of vitamin K and mortality in a Mediterranean population at high cardiovascular disease risk. A prospective cohort analysis was conducted in 7216 participants from the PREDIMED (Prevención con Dieta Mediterránea) study (median follow-up of 4.8 y). Energy and nutrient intakes were evaluated using a validated 137-item food frequency questionnaire. Dietary vitamin K intake was calculated annually using the USDA food composition database and other published sources. Deaths were ascertained by an end-point adjudication committee unaware of the dietary habits of participants after they had reviewed medical records and linked up to the National Death Index. Cox proportional hazard models were fitted to assess the RR of mortality. Energy-adjusted baseline dietary phylloquinone intake was inversely associated with a significantly reduced risk of cancer and all-cause mortality after controlling for potential confounders (HR: 0.54; 95% CI: 0.30, 0.96; and HR: 0.64; 95% CI: 0.45, 0.90, respectively). In longitudinal assessments, individuals who increased their intake of phylloquinone or menaquinone during follow-up had a lower risk of cancer (HR: 0.64; 95% CI: 0.43, 0.95; and HR: 0.41; 95% CI: 0.26, 0.64, respectively) and all-cause mortality (HR: 0.57; 95% CI: 0.44, 0.73; and HR: 0.55; 95% CI: 0.42, 0.73, respectively) than individuals who decreased or did not change their intake. Also, individuals who increased their intake of dietary phylloquinone had a lower risk of cardiovascular mortality risk (HR: 0.52; 95% CI: 0.31, 0.86). However, no association between cha
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- 2014
25. Effects of 1-year intervention with a mediterranean diet on plasma Fatty Acid composition and metabolic syndrome in a population at high cardiovascular risk
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Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Lopez-Sabater, M Carmen, Ros, Emilio, Lamuela-Raventos, Rosa, Martinez-Gonzalez, Miguel A, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Fito, Montserrat, Covas, Maria Isabel, Estruch, Ramon, Castellote, Ana I, Chisaguano, Maribel, Sala-Vila, Aleix, Mayneris-Perxachs, Jordi, FERNÁNDEZ BALLART, JOAN DOMÈNECH, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Lopez-Sabater, M Carmen, Ros, Emilio, Lamuela-Raventos, Rosa, Martinez-Gonzalez, Miguel A, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Fito, Montserrat, Covas, Maria Isabel, Estruch, Ramon, Castellote, Ana I, Chisaguano, Maribel, Sala-Vila, Aleix, Mayneris-Perxachs, Jordi, FERNÁNDEZ BALLART, JOAN DOMÈNECH, and BULLÓ BONET, MÒNICA
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Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention.A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet.After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and ?-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-?-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and ?-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants.The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat con
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- 2014
26. Dietary Magnesium Intake Is Inversely Associated with Mortality in Adults at High Cardiovascular Disease Risk
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Salas-Savado, Jordi, SALAS SALVADÓ, JORGE, Ruiz-Gutierrez, Valentina, Lamuela-Raventos, Rosa M, Pinto, Xavier, Babio, Nancy, BABIO SÁNCHEZ, NANCY ELVIRA, Serra-Majem, Lluis, Angel Munoz, Miguel, Lapetra, Jose, Fiol, Miquel, Gomez-Gracia, Enrique, Aros, Fernando, Covas, Maribel, Ros, Emilio, Martinez-Gonzalez, Miguel A, Corella, Dolores, Estruch, Ramon, Guasch-Ferre, Marta, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Salas-Savado, Jordi, SALAS SALVADÓ, JORGE, Ruiz-Gutierrez, Valentina, Lamuela-Raventos, Rosa M, Pinto, Xavier, Babio, Nancy, BABIO SÁNCHEZ, NANCY ELVIRA, Serra-Majem, Lluis, Angel Munoz, Miguel, Lapetra, Jose, Fiol, Miquel, Gomez-Gracia, Enrique, Aros, Fernando, Covas, Maribel, Ros, Emilio, Martinez-Gonzalez, Miguel A, Corella, Dolores, Estruch, Ramon, Guasch-Ferre, Marta, and BULLÓ BONET, MÒNICA
- Abstract
The relation between dietary magnesium intake and cardiovascular disease (CVD) or mortality was evaluated in several prospective studies, but few of them have assessed the risk of all-cause mortality, which has never been evaluated in Mediterranean adults at high cardiovascular risk. The aim of this study was to assess the association between magnesium intake and CVD and mortality risk in a Mediterranean population at high cardiovascular risk with high average magnesium intake. The present study included 7216 men and women aged 55-80 y from the PREDIMED (Prevención con Dieta Mediterránea) study, a randomized clinical trial. Participants were assigned to 1 of 2 Mediterranean diets (supplemented with nuts or olive oil) or to a control diet (advice on a low-fat diet). Mortality was ascertained by linkage to the National Death Index and medical records. We fitted multivariable-adjusted Cox regressions to assess associations between baseline energy-adjusted tertiles of magnesium intake and relative risk of CVD and mortality. Multivariable analyses with generalized estimating equation models were used to assess the associations between yearly repeated measurements of magnesium intake and mortality. After a median follow-up of 4.8 y, 323 total deaths, 81 cardiovascular deaths, 130 cancer deaths, and 277 cardiovascular events occurred. Energy-adjusted baseline magnesium intake was inversely associated with cardiovascular, cancer, and all-cause mortality. Compared with lower consumers, individuals in the highest tertile of magnesium intake had a 34% reduction in mortality risk (HR: 0.66; 95% CI: 0.45, 0.95; P < 0.01). Dietary magnesium intake was inversely associated with mortality risk in Mediterranean individuals at high risk of CVD. This trial was registered at controlled-tri
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- 2014
27. Trends in food availability determined by the Food and Agriculture Organization¿s food balance sheets in Mediterranean Europe in comparison with other European areas
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Carmen Pérez-Rodrigo, Pilar García-Lorda, Jordi Salas-Salvadó, Rafael Balanza, Mònica Bulló Bonet, Javier Aranceta, Alimentació, Nutrició, Creixement i Salut Mental, Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Mediterranean climate ,Mediterranean diet ,Food availability ,Medicine (miscellaneous) ,Wine ,Diet, Mediterranean ,Bioquímica i biotecnologia ,Diet Surveys ,Dieta mediterrània ,Agricultural economics ,Food Supply ,Food group ,Vegetables ,Dietary Carbohydrates ,Cluster Analysis ,Humans ,Plant Oils ,Olive Oil ,Bioquímica y tecnología ,Nutrition and Dietetics ,Food security ,1368-9800 ,business.industry ,Mediterranean Region ,Public Health, Environmental and Occupational Health ,Ecological study ,Feeding Behavior ,Food Patterns ,Dietary Fats ,Diet ,Europe ,Biochemistry and technology ,Geography ,Agriculture ,Fruit ,business ,Edible Grain ,Energy Intake - Abstract
ObjectiveThe aims of this study were to assess the changes that have occurred in food patterns in Europe over the last 40 years based on food availability data and to compare the stability of the traditional Mediterranean diet in the south of Europe in this period.DesignAn ecological study carried out on the basis of Food and Agriculture Organization food balance sheets for three geographical areas of Europe (Mediterranean, north and east) over two time periods: 1961–1963 and 1998–2000. The average availability of total energy, energy provided from macronutrients and food groups was calculated for each area and each period studied.ResultsOver the last 40 years total energy availability and energy availability from lipids have increased considerably in the three European areas, while the percentage of energy from carbohydrates has fallen. The greatest changes have occurred in Mediterranean Europe, with an increase of 20.1% in total energy availability, an increase of 48.1% in energy availability from lipids and a fall of 20.5% from carbohydrates. Moreover, Mediterranean Europe showed a significant fall in the energy supplied by cereals (29.9%) and wine (55.2%), while the contribution of milk (77.8%) and dairy products (23.6%) increased.ConclusionsThe results of this study suggest that European Mediterranean countries should take nutrition policy action to maintain their traditional healthy food pattern, with a cultural added value. This implies actions at all levels, including raising awareness of consumers, collaboration with the food sector and a call to set the agenda of the concerned politicians and stakeholders.
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- 2007
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28. Conjugated linoleic acid intake in humans: a review focusing on its effect on body composition, glucose and lipid metabolism
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SALAS SALVADÓ, JORGE, F. MARQUEZ-SANDOVAL, BULLÓ BONET, MÒNICA, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Biochemistry and technology ,Bioquímica y tecnología ,conjugated linoleic acid (CLAs) ,glucose metabolism ,1040-8398 ,lipid metabolism ,food and beverages ,Àcid linoleic ,Lípids -- Metabolisme ,lipids (amino acids, peptides, and proteins) ,Glucosa -- Metabolisme ,Bioquímica i biotecnologia - Abstract
Studies performed on different species show that the consumption of conjugated linoleic acid (CLA) leads to a loss of fat and total body weight, reduces the plasma concentrations of total and LDL cholesterol, and has an anti-inflammatory effect. This article reviews the clinical trials on human beings that evaluate how mixtures of CLA isomers administered as supplements or CLA-enriched products can affect total body weight, body composition, plasma lipid profile, glycemia, insulinemia, insulin sensitivity, lipid oxidation, and inflammation. After analyzing the few studies published to date in reduced samples of healthy humans or patients with overweight, obesity, metabolic syndrome, or diabetes, we deduce that there is not enough evidence to show that conjugated linoleic acid has an effect on weight and body composition in humans. However, some of these studies have observed that the administration of various CLA isomers has adverse effects on lipid profile (it decreases HDL cholesterol concentration and increases Lp (a) circulating levels), glucose metabolism (glycemia, insulinemia or insulin sensitivity), lipid oxidation, inflammation, or endothelial function. Therefore, long-term randomized clinical trials, controlled with placebo, need to be made in large samples of patients to evaluate the efficacy and safety of CLA isomers before its indiscriminate use in human beings can be recommended.
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- 2006
29. [Micronutrients in HIV-infection and the relationship with the inflammatory response]
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María Jesús, Jiménez-Expósito, Mònica, Bulló Bonet, Carlos, Alonso-Villaverde, Pilar, Serrano, Pilar, García-Lorda, Pedro Pablo, García-Luna, Lluís, Masana, and Jordi, Salas-Salvadó
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Adult ,Inflammation ,Male ,Zinc ,Humans ,Vitamin E ,Female ,HIV Infections ,Middle Aged ,Vitamin A ,Copper ,Aged - Abstract
Our aim was to measure the plasma concentrations of various vitamins and micronutrients involved in the immune response and antioxidant systems of an HIV+ population and to determine how they are related to the inflammatory response.We studied 86 subjects with known HIV-infection who were divided into three groups (asymptomatic HIV+; AIDS without opportunistic infection; and AIDS with active opportunistic infection) which were compared with a control group. Serum concentrations of vitamin A, vitamin E, copper and zinc were measured, as well as several inflammatory parameters. Absorption tests for fat and sugar were performed in all patients.Serum vitamin A and E levels were below the reference range in 36.4% and 14.3% patients, respectively, but not in controls subjects. The prevalence of vitamin A deficiency increased with the severity of the disease. Fewer patients than controls had values below the reference range regarding serum copper. AIDS patients with active opportunistic infection showed significantly lower serum concentrations of vitamin A (p0.001) and significantly higher serum concentrations of copper (p0.0001). Both serum concentrations of vitamin A and copper were correlated with various inflammatory parameters.Micronutrient deficiencies are prevalent in HIV-infected patients including asymptomatic patients. Vitamin A and copper were significantly correlated with inflammatory parameters, suggesting that their serum concentrations have more to do with the inflammatory response than with the nutritional status.
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- 2003
30. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expresion
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BULLÓ BONET, MÒNICA, Pilar García-Lorda, Isabel Megias, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
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Biochemistry and technology ,Bioquímica y tecnología ,TNF- system ,1071-7323 ,Bioquímica i biotecnologia ,albumin ,Factor de necrosi tumoral ,C-reactive protein - Abstract
OBJECTIVES: To explore the links between tumor necrosis factor alpha (TNFalpha) and leptin adipose tissue expression and low-grade systemic inflammation and to determine the relationship between inflammation and the degree of adiposity, the presence of type 2 diabetes, and other cardiovascular risk factors. RESEARCH METHODS AND PROCEDURES: Ninety-one women (BMI 19 to 65 kg/m(2)) were divided into tertiles of CRP. Insulin resistance was calculated using the HOMA method. Albumin, fibrinogen, C-reactive protein (CRP), interleukin-6, sTNFR1, sTNFR2, and leptin levels were measured in serum and plasma samples. TNFalpha and leptin expression were measured by reverse transcription-polymerase chain reaction in abdominal subcutaneous adipose tissue samples. RESULTS: CRP was positively related to BMI and upper distribution of adiposity. TNFalpha and leptin adipose tissue expression were higher in the upper tertile of CRP. Also, peripheral levels of both soluble TNFRs and leptin were higher in patients with the greatest inflammation degree. Diabetes, dislipidemia, and hypertension were most prevalent in patients in the upper CRP tertile. Inflammatory markers of diabetic women were significantly different from those of nondiabetic women, even after adjusting for differences in body fat. BMI, type 2 diabetes, and adipose TNFalpha mRNA levels were significant predictors of serum CRP levels (r(2) = 0.28, p < 0.001). DISCUSSION: These results are in agreement with the hypothesis that the synthesis of adipose tissue TNFalpha and leptin could induce the production of interleukin-6, CRP, and other acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation state involved in the progression of obesity and its associated comorbidities.
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- 2003
31. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Saez, Guillermo T, Chaves, Javier, Zaragoza, Cristobal, Iradi, Antonio, Moreno, Juan Jose, Casillas, Rosario, Cerda, Concha, Tormos, Carmen, Fito, Montserrat, Sanchez, Julia M, Martinez-Gonzalez, Miguel Angel, Corella, Dolores, Lamuela-Raventos, Rosa, Estruch, Ramon, Borrego, Silvia, Covas, Maria-Isabel, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Fandos, Marta, Mitjavila, Maria Teresa, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Saez, Guillermo T, Chaves, Javier, Zaragoza, Cristobal, Iradi, Antonio, Moreno, Juan Jose, Casillas, Rosario, Cerda, Concha, Tormos, Carmen, Fito, Montserrat, Sanchez, Julia M, Martinez-Gonzalez, Miguel Angel, Corella, Dolores, Lamuela-Raventos, Rosa, Estruch, Ramon, Borrego, Silvia, Covas, Maria-Isabel, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Fandos, Marta, Mitjavila, Maria Teresa, and BULLÓ BONET, MÒNICA
- Abstract
Metabolic syndrome (MetS), in which a non-classic feature is an increase in systemic oxidative biomarkers, presents a high risk of diabetes and cardiovascular disease (CVD). Adherence to the Mediterranean Diet (MedDiet) is associated with a reduced risk of MetS. However, the effect of the MedDiet on biomarkers for oxidative damage has not been assessed in MetS individuals. We have investigated the effect of the MedDiet on systemic oxidative biomarkers in MetS individuals.Randomized, controlled, parallel clinical trial in which 110 female with MetS, aged 55-80, were recruited into a large trial (PREDIMED Study) to test the efficacy of the traditional MedDiet on the primary prevention of CVD. Participants were assigned to a low-fat diet or two traditional MedDiets (MedDiet + virgin olive oil or MedDiet + nuts). Both MedDiet group participants received nutritional education and either free extra virgin olive oil for all the family (1 L/week), or free nuts (30 g/day). Diets were ad libitum. Changes in urine levels of F2-Isoprostane (F2-IP) and the DNA damage base 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) were evaluated at 1-year trial.After 1-year urinary F2-IP decreased in all groups, the decrease in MedDiet groups reaching a borderline significance versus that of the Control group. Urinary 8-oxo-dG was also reduced in all groups, with a higher decrease in both MedDiet groups versus the Control one (P < 0.001).MedDiet reduces oxidative damage to lipids and DNA in MetS individuals. Data from this study provide evidence to recommend the traditional MedDiet as a useful tool in the MetS management.Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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- 2013
32. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: The PREDIMED study
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Lamuela-Raventos, R M, Estruch, R, Warnberg, J, Ruiz-Gutierrez, V, Saez, G T, Munoz, M A, Pinto, X, Serra-Majem, L, Fiol, M, Aros, F, Lapetra, J, Gomez-Gracia, E, SALAS SALVADÓ, JORGE, Corella, D, Covas, M I, Martinez-Gonzalez, M A, Perez-Jimenez, J, Medina-Remon, A, Tresserra-Rimbau, A, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Lamuela-Raventos, R M, Estruch, R, Warnberg, J, Ruiz-Gutierrez, V, Saez, G T, Munoz, M A, Pinto, X, Serra-Majem, L, Fiol, M, Aros, F, Lapetra, J, Gomez-Gracia, E, SALAS SALVADÓ, JORGE, Corella, D, Covas, M I, Martinez-Gonzalez, M A, Perez-Jimenez, J, Medina-Remon, A, Tresserra-Rimbau, A, and BULLÓ BONET, MÒNICA
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Epidemiological data have shown an inverse association between the consumption of polyphenol-rich foods and the risk of cardiovascular disease or overall mortality. A comprehensive estimation of individual polyphenol intake in nutritional cohorts is needed to gain a better understanding of this association. The aim of this study was to estimate the quantitative intake of polyphenols and the major dietary sources in the PREDIMED (PREvención con DIeta MEDiterránea) cohort using individual food consumption records.The PREDIMED study is a large, parallel-group, multicentre, randomised, controlled 5-year feeding trial aimed at assessing the effects of the Mediterranean diet on the primary prevention of cardiovascular disease. A total of 7200 participants, aged 55-80 years, completed a validated 1-year food frequency questionnaire (FFQ) at baseline. Polyphenol consumption was calculated by matching food consumption data from the FFQ with the recently developed Phenol-Explorer database on polyphenol content in foods. The mean total polyphenol intake was 820 ± 323 mg day?¹ (443 ± 218 mg day?¹ of flavonoids and 304 ± 156 mg day?¹ of phenolic acids). Hydroxycinnamic acids were the phenolic group with the highest consumption and 5-caffeoylquinic acid was the most abundantly ingested individual polyphenol. The consumption of olives and olive oil was a differentiating factor in the phenolic profile of this Spanish population compared with other countries.In Mediterranean countries, such as Spain, the main dietary source of polyphenols is coffee and fruits, but the most important differentiating factor with respect to other countries is the consumption of polyphenols from olives and olive oil.Copyright © 2012 Elsevier B.V. All rights reserved.
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- 2013
33. Association between Serum Ferritin and Osteocalcin as a Potential Mechanism Explaining the Iron-Induced Insulin Resistance
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Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Casas, R, Toledo, E, Guasch-Ferré, M, Diaz, A, Ibarrola-Jurado, N, Fernández-Ballart, JD, Basora, J, Arija-Val, V, Fiol, M, Estruch, R, Martinez-Gonzalez, MA, SALAS SALVADÓ, JORGE, Cándido-Fernández, J, Juanola-Falgarona, M, BULLÓ BONET, MÒNICA, BABIO SÁNCHEZ, NANCY ELVIRA, Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Casas, R, Toledo, E, Guasch-Ferré, M, Diaz, A, Ibarrola-Jurado, N, Fernández-Ballart, JD, Basora, J, Arija-Val, V, Fiol, M, Estruch, R, Martinez-Gonzalez, MA, SALAS SALVADÓ, JORGE, Cándido-Fernández, J, Juanola-Falgarona, M, BULLÓ BONET, MÒNICA, and BABIO SÁNCHEZ, NANCY ELVIRA
- Abstract
Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood. Because a reduction of circulating osteocalcin levels after iron overload have been demonstrated in cell cultures, and osteocalcin is related to glucose and insulin metabolism, the iron-induced osteocalcin reductions could contribute to explain the role of iron metabolism in the development of type 2 diabetes mellitus.To analyzed the associations between serum total and uncarboxylated osteocalcin and adiponectin concentrations with serum ferritin and soluble transferrin receptor (sTfR) in elderly subjects.We evaluated a total of 423 subjects from the PREDIMED cohort in a population-based cross-sectional analysis. Extensive clinical, nutritional and laboratory measurements, including total and uncarboxylated osteocalcin, adiponectin, ferritin and sTfR were recorded.Serum ferritin was positively correlated with increased glucose and insulin circulating levels but also with HOMA-IR, and was inversely associated with total osteocalcin and adiponectin. A regression analysis revealed that serum ferritin and transferrin receptor levels were significantly associated with a decrease in total and uncarboxylated osteocalcin. Serum sTfR levels were associated with lower uncarboxylated osteocalcin levels in the whole-study subjects and remained significant only in the IFG (impaired fasting glucose) individuals.We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.Controlled-Trials.com ISRCTN35
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- 2013
34. Serum sTWEAK Concentrations and Risk of Developing Type 2 Diabetes in a High Cardiovascular Risk Population: A Nested Case-Control Study
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Bioquímica i Biotecnologia, Medicina i Cirurgia, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Covas, Maria-Isabel, Diez-Espino, Javier, Basora, Josep, Vendrell, Joan, Estruch, Ramon, Martinez-Gonzalez, Miguel A, Chacon, Matilde R, Diaz-Lopez, Andres, VENDRELL ORTEGA, JUAN JOSÉ, MAYMO MASIP, ELSA, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Medicina i Cirurgia, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Covas, Maria-Isabel, Diez-Espino, Javier, Basora, Josep, Vendrell, Joan, Estruch, Ramon, Martinez-Gonzalez, Miguel A, Chacon, Matilde R, Diaz-Lopez, Andres, VENDRELL ORTEGA, JUAN JOSÉ, MAYMO MASIP, ELSA, and BULLÓ BONET, MÒNICA
- Abstract
Because serum concentrations of soluble forms of TNF-like weak inducer of apoptosis (sTWEAK) and scavenger receptor CD163 (sCD163) have been associated with insulin resistance and type 2 diabetes mellitus (T2D), we tested the associations of sTWEAK and sCD163 with the future development of T2D in elderly subjects at high cardiovascular risk.A prospective, matched case-control study of 153 cases of newly diagnosed diabetic subjects and 306 individually matched controls who did not develop diabetes during a mean 5-year follow-up was conducted using data from the PREDIMED study. Conditional logistic regression was used to estimate the matched odds ratio (OR) for incident T2D according to categories of baseline sTWEAK and sCD163 concentrations measured by ELISA.Baseline sTWEAK concentrations were lower in cases than controls. There were no case-control differences in sCD163 concentrations. In the conditional logistic model that took into account the matching factors, the ORs for T2D incidence in the highest vs the lowest quartile of sTWEAK and the sCD163/sTWEAK ratio were 0.49 (95% confidence interval [CI], 0.31-0.76; P for trend <.01) and 1.67 (95% CI, 1.06-2.63; P for trend = .05), respectively. Further adjustment for potential lifestyle confounding factors had little impact on these estimates, whereas adjustment for metabolic syndrome components and fasting insulin levels attenuated the magnitude of associations and only the sTWEAK remained statistically significant (OR = 0.63; 95% CI, 0.40-0.98; P for trend = .05).These findings indicate that in a population at high cardiovascular risk, reduced circulating levels of sTWEAK are associated with an increased risk of diabetes incidence.
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- 2013
35. Cross-Sectional Assessment of Nut Consumption and Obesity, Metabolic Syndrome and Other Cardiometabolic Risk Factors: The PREDIMED Study
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Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Basora, Josep, BABIO SÁNCHEZ, NANCY ELVIRA, Covas, Maria-Isabel, Pinto, Xavier, Serra-Majem, Lluis, Vinyoles, Ernest, Aros, Fernando, Roman, Pilar, Estruch, Ramon, Waernberg, Julia, Fiol, Miquel, Corella, Dolores, Martinez-Gonzalez, Miguel A, Ros, Emilio, Guasch-Ferre, Marta, Ibarrola-Jurado, Nuria, FERNÁNDEZ BALLART, JOAN DOMÈNECH, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Basora, Josep, BABIO SÁNCHEZ, NANCY ELVIRA, Covas, Maria-Isabel, Pinto, Xavier, Serra-Majem, Lluis, Vinyoles, Ernest, Aros, Fernando, Roman, Pilar, Estruch, Ramon, Waernberg, Julia, Fiol, Miquel, Corella, Dolores, Martinez-Gonzalez, Miguel A, Ros, Emilio, Guasch-Ferre, Marta, Ibarrola-Jurado, Nuria, FERNÁNDEZ BALLART, JOAN DOMÈNECH, and BULLÓ BONET, MÒNICA
- Abstract
Prospective studies have consistently suggested that nut consumption is inversely related to fatal and non-fatal coronary heart disease. Limited data are available on the epidemiological associations between nut intake and cardiometabolic risk factors.To evaluate associations between frequency of nut consumption and prevalence of cardiometabolic risk factors [obesity, metabolic syndrome (MetS), type-2 diabetes, hypertension, and dyslipidemia] in a Mediterranean population at high cardiovascular risk.Cross-sectional study of 7,210 men and women (mean age, 67 y) recruited into the PREDIMED study. MetS was defined by the harmonized ATPIII and IDF criteria. Diabetes and hypertension were assessed by clinical diagnosis and dyslipidemia (high triglycerides, low HDL-cholesterol, and hypercholesterolemia) by lipid analyses. Nut consumption was assessed using a validated food frequency questionnaire and categorized as <1, 1-3, and >3 servings/wk. Control of confounding was done with multivariate logistic regression.Compared to participants consuming <1 serving/wk of nuts, those consuming >3 servings/wk had lower adjusted odds ratios (OR) for obesity (0.61, 95% confidence interval 0.54 to 0.68; P-trend <0.001), MetS (0.74, 0.65 to 0.85; P-trend<0.001), and diabetes (0.87, 0.78 to 0.99; P-trend?=?0.043). Higher nut consumption was also associated with lower risk of the abdominal obesity MetS criterion (OR 0.68, 0.60 to 0.79; P-trend<0.001). No significant associations were observed for the MetS components high blood pressure, dyslipidemia, or elevated fasting glucose.Nut consumption was inversely associated with the prevalence of general obesity, central obesity, MetS, and diabetes in subjects at high cardiovascular risk.
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- 2013
36. Changes in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Serra-Majem, L, Portillo-Baquedano, M P, Ruiz-Gutierrez, V, Pinto, X, Tur, J, Gomez-Gracia, E, Munoz, M A, Lapetra, J, Fiol, M, Ros, E, Lamuela-Raventos, R M, Alvarez-Perez, J, Schroder, H, Covas, M I, SALAS SALVADÓ, JORGE, Corella, D, Estruch, R, Sanchez-Villegas, A, Bautista-Castano, I, QUILEZ GRAU, JUAN, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Serra-Majem, L, Portillo-Baquedano, M P, Ruiz-Gutierrez, V, Pinto, X, Tur, J, Gomez-Gracia, E, Munoz, M A, Lapetra, J, Fiol, M, Ros, E, Lamuela-Raventos, R M, Alvarez-Perez, J, Schroder, H, Covas, M I, SALAS SALVADÓ, JORGE, Corella, D, Estruch, R, Sanchez-Villegas, A, Bautista-Castano, I, QUILEZ GRAU, JUAN, and BULLÓ BONET, MÒNICA
- Abstract
The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over time. Dietary habits were assessed with validated FFQ at baseline and repeatedly every year during 4 years of follow-up. Using multivariate models to adjust for covariates, long-term weight and waist circumference changes according to quartiles of change in energy-adjusted white and whole-grain bread consumption were calculated. The present results showed that over 4 years, participants in the highest quartile of change in white bread intake gained 0·76 kg more than those in the lowest quartile (P for trend = 0·003) and 1·28 cm more than those in the lowest quartile (P for trend < 0·001). No significant dose-response relationships were observed for change in whole-bread consumption and anthropometric measures. Gaining weight (>2 kg) and gaining waist circumference (>2 cm) during follow-up was not associated with increase in bread consumption, but participants in the highest quartile of changes in white bread intake had a reduction of 33 % in the odds of losing weight (>2 kg) and a reduction of 36 % in the odds of losing waist circumference (>2 cm). The present results suggest that reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat.
- Published
- 2013
37. Cross-sectional associations between macronutrient intake and chronic kidney disease in a population at high cardiovascular risk
- Author
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Isabel Covas, Maria, Pinto, Xavier, Ros, Emilio, Lapetra, Jose, Aros, Fernando, Serra-Majem, Lluis, Waernberg, Julia, Estruch, Ramon, Guasch-Ferre, Marta, Angel Martinez-Gonzalez, Miguel, Basora, Josep, Diaz-Lopez, Andres, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Salas-Salvado, Jordi, SALAS SALVADÓ, JORGE, Isabel Covas, Maria, Pinto, Xavier, Ros, Emilio, Lapetra, Jose, Aros, Fernando, Serra-Majem, Lluis, Waernberg, Julia, Estruch, Ramon, Guasch-Ferre, Marta, Angel Martinez-Gonzalez, Miguel, Basora, Josep, Diaz-Lopez, Andres, and BULLÓ BONET, MÒNICA
- Abstract
The aim was to examine the associations between macronutrient intake and the prevalence of chronic kidney disease (CKD) or microalbuminuria (MiA) in individuals at high cardiovascular risk.Cross-sectional analyses conducted in 2123 nondiabetic individuals from the PREDIMED study. Dietary data were collected using a food-frequency questionnaire. Analysis of covariance was used to assess associations between quartiles of nutrient intake and estimated glomerular filtration rate (eGFR) or urinary albumin-to-creatinine ratio (ACR). The odds ratio (OR) for the presence of CKD or MiA according to quartiles of nutrient intake was assessed by logistic regression models.Individuals in the highest quartile of n-6 polyunsaturated fatty acid (PUFA) intake showed lower average eGFR. Individuals in the top quartile of fiber intake had a decreased risk of CKD [OR: 0.68; 95% CI: 0.48-0.95]. Conversely, subjects in the highest quartile of n-6 PUFA intake showed an increased risk of CKD [OR: 1.44; 95% CI: 1.03-2.01]. No significant associations were found between the intake of other macronutrients and eGFR, urinary ACR or risk of CKD or MiA.A high fiber intake was associated with a decreased risk of CKD, while a high n-6 PUFA intake was inversely associated with eGFR and directly associated with an increased risk of CKD.Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
- Published
- 2013
38. Micronutrientes en la infección VIH y su relación con la respuesta inflamatoria
- Author
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BULLÓ BONET, MÒNICA, Maria Jesus Jimenez Exposito, Carlos Alonso Villaverde, Pilar Serrano, Pilar Garcia Lorda, Pedro Pablo Garcia Luna, Lluis Masana, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
- Subjects
Biochemistry and technology ,Vitamines ,Bioquímica y tecnología ,0025-7753 ,oligoelements ,oligoelementos ,VIH (Virus) ,VIH ,HIV infection ,vitamins ,Bioquímica i biotecnologia ,vitaminas - Abstract
Background: Our aim was to measure the plasma concentrations of various vitamins and micronutrients involved in the immune response and antioxidant systems of an HIV+ population and to determine how they are related to the inflammatory response. Patients and method: We studied 86 subjects with known HIV-infection who were divided into three groups (asymptomatic HIV+; AIDS without opportunistic infection; and AIDS with active opportunistic infection) which were compared with a control group. Serum concentrations of vitamin A, vitamin E, copper and zinc were measured, as well as several inflammatory parameters. Absorption tests for fat and sugar were performed in all patients. Results: Serum vitamin A and E levels were below the reference range in 36.4% and 14.3% patients, respectively, but not in controls subjects. The prevalence of vitamin A deficiency increased with the severity of the disease. Fewer patients than controls had values below the reference range regarding serum copper. AIDS patients with active opportunistic infection showed significantly lower serum concentrations of vitamin A (p < 0.001) and significantly higher serum concentrations of copper (p < 0.0001). Both serum concentrations of vitamin A and copper were correlated with various inflammatory parameters. Conclusions: Micronutrient deficiencies are prevalent in HIV-infected patients including asymptomatic patients. Vitamin A and copper were significantly correlated with inflammatory parameters, suggesting that their serum concentrations have more to do with the inflammatory response than with the nutritional status. Fundamento: Describir las concentraciones séricas de ciertas vitaminas y micronutrientes relacionados con la respuesta inmunitaria y el sistema antioxidante, en una población de individuos con infección por el virus de la inmunodeficiencia humana (VIH) y determinar su relación con la respuesta inflamatoria. Pacientes y método: Se incluyó a 86 individuos con infección por el VIH documentada; divididos en tres grupos (VIH-positivos asintomáticos; sida sin infección oportunista y sida con infección oportunista activa), que fueron comparados con un grupo control. Se determinaron los valores plasmáticos de vitamina A, vitamina E, cobre y cinc, así como parámetros inflamatorios. En todos los pacientes se realizaron pruebas de absorción de grasas e hidratos de carbono. Resultados: Se detectaron valores inferiores a los intervalos de referencia de vitamina A y E en el 36,4 y el 14,3% de los pacientes, respectivamente, y en ninguno de los controles. La prevalencia del déficit de vitamina A aumentó con la gravedad de la enfermedad. La prevalencia de pacientes con concentraciones de cobre por debajo de los intervalos de referencia fue inferior a la de los sujetos controles. Los individuos con sida e infección oportunista activa presentaron concentraciones de vitamina A significativamente inferiores (p < 0,001) y superiores de cobre (p < 0,0001). Tanto las concentraciones de vitamina A como las de cobre se correlacionaron con diversos parámetros inflamatorios. Conclusiones: Los déficit de micronutrientes son prevalentes en individuos con infección por el VIH desde estadios iniciales de la enfermedad. La disminución de la vitamina A y el aumento del cobre se correlacionan significativamente con parámetros inflamatorios, lo que sugiere que sus concentraciones plasmática
- Published
- 2002
39. High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients
- Author
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Andres-Lacueva, Cristina, Estruch, Ramon, Lapetra, Jose, Fito, Montserrat, Aros, Fernando, SALAS SALVADÓ, JORGE, Salas-Salvado, Jordi, Angel Martinez-Gonzalez, Miguel, Lamuela-Raventos, Rosa M, Urpi-Sarda, Mireia, Zamora-Ros, Raul, BABIO SÁNCHEZ, NANCY ELVIRA, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Andres-Lacueva, Cristina, Estruch, Ramon, Lapetra, Jose, Fito, Montserrat, Aros, Fernando, SALAS SALVADÓ, JORGE, Salas-Salvado, Jordi, Angel Martinez-Gonzalez, Miguel, Lamuela-Raventos, Rosa M, Urpi-Sarda, Mireia, Zamora-Ros, Raul, BABIO SÁNCHEZ, NANCY ELVIRA, and BULLÓ BONET, MÒNICA
- Abstract
Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-sectional study including high CV risk individuals in Spain. We studied 1000 participants in the PREDIMED Study in whom TRMs were analyzed by LC-MS/MS with a previous solid phase extraction. Multiple linear regression of TRMs (biomarker of wine consumption) improved the mean (95% CI) of HDL [0.168 (0.027-0.309); P=0.02] and triglyceride [-1.012 (-1.797 to -0.227); P=0.012] plasma concentrations and heart rate [-0.259 (-0.412 to -0.107); P<0.001]. Models of TRMs adjusted for alcohol (biomarker of resveratrol intake) decreased fasting blood glucose [-0.533 (-1.034 to -0.033); P=0.037] and triglyceride [-1.014 (-1.998 to -0.029); P=0.044] concentrations, and heart rate [-0.277 (-0.467 to -0.087); P=0.004]. Both resveratrol and wine intake, evaluated as TRMs, were associated with beneficial changes in blood lipid profiles, fasting blood glucose (only resveratrol) and heart rate, suggesting that resveratrol intake via wine consumption might help to decrease CV risk factors.Copyright © 2012 Elsevier Ltd. All rights reserved.
- Published
- 2012
40. Papel del factor tumoral en el control de las reservas grasas y la obesidad
- Author
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BULLÓ BONET, MÒNICA, P Garcia-Lorda, JM Argilés, SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, and Universitat Rovira i Virgili
- Subjects
Biochemistry and technology ,obesity ,Bioquímica y tecnología ,0025-7753 ,reservas grasas ,Obesidad ,fat reserve ,Tumor Necrosis Factor ,factor tumoral ,Bioquímica i biotecnologia ,Factor de necrosi tumoral - Abstract
The role of tumor necrosis factor in the control of fat reserve and obesity. Papel del factor tumoral en el control de las reservas grasas y la obesidad.
- Published
- 2000
41. Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women
- Author
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Bioquímica i Biotecnologia, Universitat Rovira i Virgili, SALAS SALVADÓ, JORGE, Estruch, R, BULLÓ BONET, MÒNICA, Bioquímica i Biotecnologia, Universitat Rovira i Virgili, SALAS SALVADÓ, JORGE, Estruch, R, and BULLÓ BONET, MÒNICA
- Abstract
Vitamin K may have a protective role against bone loss and osteoporotic fractures associated to aging, although data in humans are inconsistent and the mechanisms involved are still unknown. The main objective of the study was to assess the associations between vitamin K intake, bone density, bone structure quality and biochemical bone metabolism markers in elderly subjects. We also analyzed the relationship between changes in vitamin K intake and the evolution of bone quality markers after two years of follow-up.Cross-sectional analysis was carried out on 365 elderly subjects, 200 of whom were also included in a 2-year longitudinal follow-up study. Usual dietary intakes were assessed using a semi-quantitative 137-item food frequency questionnaire (FFQ). Vitamin K intake was estimated using the USDA database. Bone biochemical markers were measured in a subset of 125 subjects. Quantitative ultrasound assessment (QUS) was performed at the calcaneus to estimate bone mineral density (BMD), speed of sound (SOS), broadband ultrasound attenuation (BUA) and the quantitative ultrasound index (QUI).Dietary intake of vitamin K was significantly associated with higher BMD and better QUS. No significant associations were found between vitamin K intake and bone biochemical markers. Those subjects who increased their vitamin K intake showed a lower loss of BMD, a lower decrease in SOS and a nonsignificant increase in BUA.High dietary vitamin K intake was associated with superior bone properties. Moreover, an increase in dietary vitamin K was significantly related to lower losses of bone mineral density and smaller increases in the porosity and elasticity attributed to aging, which helps to explain the previously described protective effect of vitamin K intake against osteoporotic frac
- Published
- 2011
42. Bone quantitative ultrasound measurements in relation to the metabolic syndrome and type 2 diabetes mellitus in a cohort of elderly subjects at high risk of cardiovascular disease from the PREDIMED study.
- Author
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; M. GARCIA-ALOY; J. BASORA; M.I. COVAS; SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; M. GARCIA-ALOY; J. BASORA; M.I. COVAS; SALAS SALVADÓ, JORGE
- Abstract
OBJECTIVE: The aim of this study is to determine whether metabolic syndrome, its individual components, or the presence of type 2 diabetes mellitus are associated with a better bone status estimated by quantitative ultrasound at the calcaneus. DESIGN: Cross-sectional study. SETTING: Outpatient clinics. PARTICIPANTS: 251 elderly subjects at high cardiovascular risk from the PREDIMED study were included. MEASUREMENTS: MetS was defined according to the ATPIII diagnosis criteria. Calcaneus quantitative ultrasound (QUS) assessment was performed using the Sahara system. RESULTS: Subjects with MetS showed significantly lower 24-hour urinary deoxypyridinoline/creatinine (u-DPD/creatinine) levels and higher broadband ultrasound attenuation, and a tendency to higher bone mineral density (BMD) and quantitative ultrasound index (QUI) than their counterparts. Individuals with type 2 diabetes mellitus (T2DM) showed a significantly higher bone broadband ultrasound attenuation (BUA) and QUI than their non-diabetic counterparts, despite they shown a higher prevalence of osteoporotic fractures. Multiple linear regression analyses showed that quantitative ultrasound parameters were positively associated with the metabolic syndrome and T2DM. Of the bone biochemical markers, only u-DPD/creatinine was related to MetS, abdominal obesity, hypertriglyceridemia component of the MetS, and the number of features that define the MetS. CONCLUSION: This is the first study showing a positive association between MetS or T2DM with better bone status and lower bone resorption markers measured by quantitative ultrasound. Our results suggest that metabolic abnormalities have a positive effect on healthy bone in elderly subjects at high risk of cardiovascular disease.
- Published
- 2011
43. Metabolomics unveils urinary changes in subjects with metabolic syndrome following 12-week nut consumption.
- Author
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; Sara Tulipani; Rafael Llorach; Olga Jauregui; Patricia Lopez-Uriarte; Mar Garcia-Aloy; SALAS SALVADÓ, JORGE; Cristina Andres-Lacueva, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; Sara Tulipani; Rafael Llorach; Olga Jauregui; Patricia Lopez-Uriarte; Mar Garcia-Aloy; SALAS SALVADÓ, JORGE; Cristina Andres-Lacueva
- Abstract
Through an HPLC-Q-TOF-MS-driven nontargeted metabolomics approach, we aimed to discriminate changes in the urinary metabolome of subjects with metabolic syndrome (MetS), following 12 weeks of mixed nuts consumption (30 g/day), compared to sex- and age-matched individuals given a control diet. The urinary metabolome corresponding to the nut-enriched diet clearly clustered in a distinct group, and the multivariate data analysis discriminated relevant mass features in this separation. Metabolites corresponding to the discriminating ions (MS features) were then subjected to multiple tandem mass spectrometry experiments using LC-ITD-FT-MS, to confirm their putative identification. The metabolomics approach revealed 20 potential markers of nut intake, including fatty acid conjugated metabolites, phase II and microbial-derived phenolic metabolites, and serotonin metabolites. An increased excretion of serotonin metabolites was associated for the first time with nut consumption. Additionally, the detection of urinary markers of gut microbial and phase II metabolism of nut polyphenols confirmed the understanding of their bioavailability and bioactivity as a priority area of research in the determination of the health effects derived from nut consumption. The results confirmed how a nontargeted metabolomics strategy may help to access unexplored metabolic pathways impacted by diet, thereby raising prospects for new intervention targets.
- Published
- 2011
44. Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women
- Author
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, BULLÓ BONET, MÒNICA; R. Estruch; SALAS SALVADÓ, JORGE, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and BULLÓ BONET, MÒNICA; R. Estruch; SALAS SALVADÓ, JORGE
- Abstract
BACKGROUND: Vitamin K may have a protective role against bone loss and osteoporotic fractures associated to aging, although data in humans are inconsistent and the mechanisms involved are still unknown. The main objective of the study was to assess the associations between vitamin K intake, bone density, bone structure quality and biochemical bone metabolism markers in elderly subjects. We also analyzed the relationship between changes in vitamin K intake and the evolution of bone quality markers after two years of follow-up. METHODS: Cross-sectional analysis was carried out on 365 elderly subjects, 200 of whom were also included in a 2-year longitudinal follow-up study. Usual dietary intakes were assessed using a semi-quantitative 137-item food frequency questionnaire (FFQ). Vitamin K intake was estimated using the USDA database. Bone biochemical markers were measured in a subset of 125 subjects. Quantitative ultrasound assessment (QUS) was performed at the calcaneus to estimate bone mineral density (BMD), speed of sound (SOS), broadband ultrasound attenuation (BUA) and the quantitative ultrasound index (QUI). RESULTS: Dietary intake of vitamin K was significantly associated with higher BMD and better QUS. No significant associations were found between vitamin K intake and bone biochemical markers. Those subjects who increased their vitamin K intake showed a lower loss of BMD, a lower decrease in SOS and a nonsignificant increase in BUA. CONCLUSIONS: High dietary vitamin K intake was associated with superior bone properties. Moreover, an increase in dietary vitamin K was significantly related to lower losses of bone mineral density and smaller increases in the porosity and elasticity attributed to aging, which helps to explain the previously described prot
- Published
- 2011
45. Un patrón de alimentación saludable: la dieta mediterránea tradicional
- Author
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Universitat Rovira i Virgili, F Márquez-Sandoval; Mònica Bulló Bonet; B Vizmanos; Patricia Casas Agustench; Jordi Salas Salvadó, Universitat Rovira i Virgili, and F Márquez-Sandoval; Mònica Bulló Bonet; B Vizmanos; Patricia Casas Agustench; Jordi Salas Salvadó
- Abstract
Several epidemiological studies and some intervention trials suggest that the traditional Mediterranean diet (the dietary pattern characteristic of the Mediterranean countries in the 1960s) may protect against chronic diseases and mortality. The most significant features attributed to this pattern are a high intake of vegetables, legumes, fruits, nuts, whole grains, and olive oil; a moderate-to-high intake of fish; a low-tomoderate intake of some dairy products; a low intake of meat and saturated fatty acids, and a regular but prudent intake of wine. In recent years, however, food habits in the Mediterranean countries have tended to move towards the patterns typical of the northern countries.
- Published
- 2008
46. Importancia de la dieta en la inflamación
- Author
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Universitat Rovira i Virgili, P Amigó-Correig; Mònica Bulló Bonet; F Márquez-Sandoval; B Vizmanos; C Alegret; Jordi Salas Salvadó, Universitat Rovira i Virgili, and P Amigó-Correig; Mònica Bulló Bonet; F Márquez-Sandoval; B Vizmanos; C Alegret; Jordi Salas Salvadó
- Abstract
In recent years, adipose tissue is no longer considered as being merely the reserves of fat in the body; rather it is considered as an endocrine organ. An excess of fat promotes the production and secretion of many adipocytokines and other substances, which participate in the regulation of energy in local and general fat stores in the body.
- Published
- 2008
47. Conjugated linoleic acid intake in humans: a review focusing on its effect on body composition, glucose and lipid metabolism
- Author
-
Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, SALAS SALVADÓ, JORGE; F. MARQUEZ-SANDOVAL; BULLÓ BONET, MÒNICA, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and SALAS SALVADÓ, JORGE; F. MARQUEZ-SANDOVAL; BULLÓ BONET, MÒNICA
- Abstract
Studies performed on different species show that the consumption of conjugated linoleic acid (CLA) leads to a loss of fat and total body weight, reduces the plasma concentrations of total and LDL cholesterol, and has an anti-inflammatory effect. This article reviews the clinical trials on human beings that evaluate how mixtures of CLA isomers administered as supplements or CLA-enriched products can affect total body weight, body composition, plasma lipid profile, glycemia, insulinemia, insulin sensitivity, lipid oxidation, and inflammation. After analyzing the few studies published to date in reduced samples of healthy humans or patients with overweight, obesity, metabolic syndrome, or diabetes, we deduce that there is not enough evidence to show that conjugated linoleic acid has an effect on weight and body composition in humans. However, some of these studies have observed that the administration of various CLA isomers has adverse effects on lipid profile (it decreases HDL cholesterol concentration and increases Lp (a) circulating levels), glucose metabolism (glycemia, insulinemia or insulin sensitivity), lipid oxidation, inflammation, or endothelial function. Therefore, long-term randomized clinical trials, controlled with placebo, need to be made in large samples of patients to evaluate the efficacy and safety of CLA isomers before its indiscriminate use in human beings can be recommended.
- Published
- 2006
48. Evaluation of lipid oxidation after ingestion of bakery products enriched with phytosterols, beta-carotene and alpha-tocopherol.
- Author
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Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, SALAS SALVADÓ, JORGE; Gemma Brufau; Joan Quilez; Miguel Angel Canela; BULLÓ BONET, MÒNICA; Magda Rafecas, Alimentació, Nutrició, Creixement i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, and SALAS SALVADÓ, JORGE; Gemma Brufau; Joan Quilez; Miguel Angel Canela; BULLÓ BONET, MÒNICA; Magda Rafecas
- Abstract
BACKGROUND AND AIMS: The aim of this study was to investigate the effect of the consumption of croissants and magdalenas (Spanish muffins), enriched with sterol esters, alpha-tocopherol and beta-carotene, on plasma lipid peroxidation. TBA and conjugated dienes were used as markers of lipid peroxidation. METHODS: The study was made to a population without changes in their diet or lifestyle, and based on a randomized double-blind controlled repeated measures design. The sample size was 57. During 8 weeks, the subjects of the control group (29) received two daily pieces (standard croissant and muffin), whereas those of the experimental group (28) received the same products, but enriched with sterol-esters, alpha-tocopherol and beta-carotene. RESULTS: The treatment has a positive effect on TBA value for control group and that given to experimental group has negative effect. The mean difference between two groups is 3.16 (P = 0.044). Also TBA was found to be significantly correlated with HDL-, LDL-cholesterol and alpha-tocopherol, both before and after treatment, but TBA was only significantly correlated with beta-carotene before treatment. Finally, the effects on LDL-cholesterol, alpha-tocopherol and TBA presented similar correlation matrices in the two groups, most correlation coefficients being significant at group level, in spite of the low sample sizes, revealing the association between treatment effects.
- Published
- 2004
49. Trends in food availability determined by the Food and Agriculture Organization's food balance sheets in Mediterranean Europe in comparison with other European areas
- Author
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Balanza, Rafael, primary, García-Lorda, Pilar, additional, Pérez-Rodrigo, Carmen, additional, Aranceta, Javier, additional, Bonet, Mònica Bulló, additional, and Salas-Salvadó, Jordi, additional
- Published
- 2007
- Full Text
- View/download PDF
50. Millora del rendiment esportiu a través del consum del remolatxa en esportistes: Una revisió sistemàtica
- Author
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Guillen Peña, Albert and Bulló Bonet, Mònica
- Subjects
Ciències de la salut ,Esportistes--Alimentació ,Health sciences ,Ciencias de la salud - Published
- 2022
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