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2,727 results on '"BRUGADA, PEDRO"'

1. Brugada Syndrome: The Syndrome of Right Bundle Branch Block, ST segment Elevation in V1 to V3 and Sudden Death

Author

Brugada, Josep, Brugada, Pedro, Brugada, Ramon, Singh, Balbir, Lokhandwala, Yash, Francis, Johnson, and Gupta, Anup

Subjects
JOURNALS: Indian Pacing and Electrophysiology Journal, Indian Pacing and Electrophysiology Journal
Abstract

In 1992 a new syndrome consisting of syncopal episodes and/or sudden death in patients with a structurally normal heart and a characteristic electrocardiogram (ECG) with a pattern of right bundle branch block with an ST segment elevation in leads V1 to V3 was described 1 In 1998 the poor prognosis of patients with the syndrome not receiving an implantable defibrillator was reported 2,3 In 1998 the genetic nature of the disease and its assotiation to a mutation in the cardiac sodium channel gene was described 4 . Because the diagnosis is easily made by means of the ECG, an increasing number of patients with the ECG pattern are being identified worldwide. In this article we will review our present knowledge concerning patients with the classical ECG pattern of the disease.

Published
2001

3. Phase 2 Re-Entry Without Ito: Role of Sodium Channel Kinetics in Brugada Syndrome Arrhythmias.

Author

Zhang, Zhaoyang, Brugada, Pedro, Weiss, James, and Qu, Zhilin

Subjects
Brugada syndrome, phase 2 re-entry, sodium channel blocker, sodium channel mutation, Humans, Animals, Guinea Pigs, Brugada Syndrome, Arrhythmias, Cardiac, Action Potentials, Sodium Channels, Potassium
Abstract

BACKGROUND: In Brugada syndrome (BrS), phase 2 re-excitation/re-entry (P2R) induced by the transient outward potassium current (Ito) is a proposed arrhythmia mechanism; yet, the most common genetic defects are loss-of-function sodium channel mutations. OBJECTIVES: The authors used computer simulations to investigate how sodium channel dysfunction affects P2R-mediated arrhythmogenesis in the presence and absence of Ito. METHODS: Computer simulations were carried out in 1-dimensional cables and 2-dimensional tissue using guinea pig and human ventricular action potential models. RESULTS: In the presence of Ito sufficient to generate robust P2R, reducing sodium current (INa) peak amplitude alone only slightly potentiated P2R. When INa inactivation kinetics were also altered to simulate reported effects of BrS mutations and sodium channel blockers, however, P2R occurred even in the absence of Ito. These effects could be potentiated by delaying L-type calcium channel activation or increasing ATP-sensitive potassium current, consistent with experimental and clinical findings. INa-mediated P2R also accounted for sex-related, day and night-related, and fever-related differences in arrhythmia risk in BrS patients. CONCLUSIONS: Altered INa kinetics synergize powerfully with reduced INa amplitude to promote P2R-induced arrhythmias in BrS in the absence of Ito, establishing a robust mechanistic link between altered INa kinetics and the P2R-mediated arrhythmia mechanism.

Published
2023

4. Spontaneous type 1 ECG and arrhythmic risk in Brugada syndrome: A meta-analysis of adjusted time-to-event data

Author

Chiotis, Sotirios, Pannone, Luigi, Doundoulakis, Ioannis, Della Rocca, Domenico Giovanni, Zafeiropoulos, Stefanos, Sorgente, Antonio, Marcon, Lorenzo, Vetta, Giampaolo, Koliastasis, Leonidas, Del Monte, Alvise, Nakasone, Kazutaka, Varvara, Stavritsa T., La Meir, Mark, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, Tsiachris, Dimitrios, Vassilikos, Vasileios, Giannopoulos, Georgios, Brugada, Pedro, Sarkozy, Andrea, Chierchia, Gian Battista, and de Asmundis, Carlo

Published
2025
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5. Posterior wall isolation via a multi-electrode radiofrequency balloon catheter: feasibility, technical considerations, endoscopic findings and comparison with cryoballoon technologies

Author

Del Monte, Alvise, Chierchia, Gian Battista, Della Rocca, Domenico Giovanni, Pannone, Luigi, Sorgente, Antonio, Bala, Gezim, Monaco, Cinzia, Mouram, Sahar, Capulzini Cremonini, Lucio, Audiat, Charles, Praet, Joke, Ramak, Robbert, Overeinder, Ingrid, Ströker, Erwin, Sieira, Juan, La Meir, Mark, Brugada, Pedro, Sarkozy, Andrea, de Asmundis, Carlo, and Almorad, Alexandre

Published
2024
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6. In Vivo Mapping of Human Ventricular Fibrillation in Brugada Syndrome: The Role of Repolarization Heterogeneity

Author

Pannone, Luigi, Della Rocca, Domenico Giovanni, Vergara, Pasquale, Sorgente, Antonio, Del Monte, Alvise, Vetta, Giampaolo, Cespon Fernandez, Maria, Talevi, Giacomo, Eltsov, Ivan, Calburean, Paul-Adrian, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Pappaert, Gudrun, Sieira, Juan, de Ravel, Thomy, Van Dooren, Sonia, Gharaviri, Ali, La Meir, Mark, Brugada, Pedro, Chierchia, Gian Battista, Sarkozy, Andrea, and de Asmundis, Carlo

Published
2024
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7. SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis

Author

Doundoulakis, Ioannis, Pannone, Luigi, Chiotis, Sotirios, Della Rocca, Domenico Giovanni, Sorgente, Antonio, Tsioufis, Panagiotis, Del Monte, Alvise, Vetta, Giampaolo, Piperis, Christos, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, La Meir, Mark, Brugada, Pedro, Tsiachris, Dimitrios, Sarkozy, Andrea, Chierchia, Gian Battista, and de Asmundis, Carlo

Published
2024
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8. Impact of anesthetic management on catheter ablation for premature ventricular complexes: insights during the COVID-19 outbreak

Author

Kazawa, Shuichiro, Sieira, Juan, Bala, Gezim, Miraglia, Vincenzo, Al Housari, Maysam, Strazdas, Antanas, Monaco, Cinzia, Pannone, Luigi, Bisignani, Antonio, Overeinder, Ingrid, Almorad, Alexandre, Raes, Matthias, Weyns, Matthias, Ghijselings, Idris, Beckers, Stefan, Brugada, Pedro, Chierchia, Gian-Battista, de Asmundis, Carlo, and Ströker, Erwin

Published
2023
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9. Pericarditis prophylactic therapy after sinus node–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia

Author

de Asmundis, Carlo, Marcon, Lorenzo, Pannone, Luigi, Della Rocca, Domenico Giovanni, Lakkireddy, Dhanunjaya, Beaver, Thomas M., Brodt, Chad R., Monaco, Cinzia, Sorgente, Antonio, Audiat, Charles, Vetta, Giampaolo, Ramak, Robbert, Overeinder, Ingrid, Kronenberger, Rani, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, Sarkozy, Andrea, Brugada, Pedro, Chierchia, Gian Battista, and La Meir, Mark

Published
2024
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10. Pentaspline catheter or cryoballoon for pulmonary vein plus posterior wall isolation in persistent atrial fibrillation: 1-Year outcomes

Author

Pannone, Luigi, Doundoulakis, Ioannis, Della Rocca, Domenico Giovanni, Sorgente, Antonio, Bisignani, Antonio, Vetta, Giampaolo, Del Monte, Alvise, Talevi, Giacomo, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, Gharaviri, Ali, La Meir, Mark, Brugada, Pedro, Sarkozy, Andrea, Chierchia, Gian Battista, and de Asmundis, Carlo

Published
2024
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11. Genetic Testing in Brugada Syndrome: A 30-Year Experience

Author

Pannone, Luigi, Bisignani, Antonio, Osei, Randy, Gauthey, Anaïs, Sorgente, Antonio, Monaco, Cinzia, Della Rocca, Domenico Giovanni, Del Monte, Alvise, Strazdas, Antanas, Mojica, Joerelle, Al Housari, Maysam, Miraglia, Vincenzo, Mouram, Sahar, Vetta, Giampaolo, Paparella, Gaetano, Ramak, Robbert, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Pappaert, Gudrun, Sieira, Juan, de Ravel, Thomy, La Meir, Mark, Sarkozy, Andrea, Brugada, Pedro, Chierchia, Gian Battista, Van Dooren, Sonia, and de Asmundis, Carlo

Published
2024
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12. Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate

Author

Angelini, Paolo, Muthupillai, Raja, Lopez, Alberto, Cheong, Benjamin, Uribe, Carlo, Hernandez, Eduardo, Coulter, Stephanie, Perin, Emerson, Molossi, Silvana, Gentile, Federico, Flamm, Scott, Lorenz, Giovanni, D'Ascenzi, Flavio, Tobis, Jonathan, Sarnari, Roberto, Corno, Antonio, Furgerson, James, Chiribiri, Amedeo, Villa, Adriana DM, Orzan, Fulvio, Brugada, Pedro, Jefferies, John, Aubry, Pierre, Towbin, Jeffrey, Thiene, Gaetano, and Tomanek, Robert

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Heart Disease, Prevention, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Death, sudden, cardiac, Heart defects, congenital, Sports medicine, Adolescent medicine, Autopsy, Diagnostic screening programs, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

Preventing sudden cardiac death (SCD) in athletes is a primary duty of sports cardiologists. Current recommendations for detecting high-risk cardiovascular conditions (hr-CVCs) are history and physical examination (H&P)-based. We discuss the effectiveness of H&P-based screening versus more-modern and accurate methods. In this position paper, we review current authoritative statements and suggest a novel alternative: screening MRI (s-MRI), supported by evidence from a preliminary population-based study (completed in 2018), and a prospective, controlled study in military recruits (in development). We present: 1. Literature-Based Comparisons (for diagnosing hr-CVCs): Two recent studies using traditional methods to identify hr-CVCs in >3,000 young athletes are compared with our s-MRI-based study of 5,169 adolescents. 2. Critical Review of Previous Results: The reported incidence of SCD in athletes is presently based on retrospective, observational, and incomplete studies. H&P's screening value seems minimal for structural heart disease, versus echocardiography (which improves diagnosis for high-risk cardiomyopathies) and s-MRI (which also identifies high-risk coronary artery anomalies). Electrocardiography is valuable in screening for potentially high-risk electrophysiological anomalies. 3. Proposed Project : We propose a prospective, controlled study (2 comparable large cohorts: one historical, one prospective) to compare: (1) diagnostic accuracy and resulting mortality-prevention performance of traditional screening methods versus questionnaire/electrocardiography/s-MRI, during 2-month periods of intense, structured exercise (in military recruits, in advanced state of preparation); (2) global costs and cost/efficiency between these two methods. This study should contribute significantly toward a comprehensive understanding of the incidence and causes of exercise-related mortality (including establishing a definition of hr-CVCs) while aiming to reduce mortality.

Published
2021

14. Pulmonary Vein Remodeling Between Atrial Fibrillation Subtypes: A Matched Comparison Cardiac Computed Tomography-Based Study Between Patients With Paroxysmal and Persistent Atrial Fibrillation

Author

Housari, Maysam Al, Miraglia, Vincenzo, Terasawa, Muryo, Kazawa, Shuichiro, Monte, Alvise Del, Bala, Gezim, Pannone, Luigi, Della Rocca, Domenico Giovanni, Cosyns, Bernard, Droogmans, Steven, Tanaka, Kaoru, Belsack, Dries, De Mey, Johan, Overeinder, Ingrid, Almorad, Alexandre, Sieira, Juan, Brugada, Pedro, Sarkozy, Andrea, Chierchia, Gian-Battista, de Asmundis, Carlo, and Ströker, Erwin

Published
2023
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15. Atrial Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging

Author

Bisignani, Antonio, Pannone, Luigi, Del Monte, Alvise, Eltsov, Ivan, Cappello, Ida Anna, Sieira, Juan, Monaco, Cinzia, Bala, Gezim, Mouram, Sahar, Della Rocca, Domenico Giovanni, Ströker, Erwin, Overeinder, Ingrid, Almorad, Alexandre, Pappaert, Gudrun, Gauthey, Anaïs, de Ravel, Thomy, Van Dooren, Sonia, Sorgente, Antonio, La Meir, Mark, Sarkozy, Andrea, Brugada, Pedro, Chierchia, Gian-Battista, and de Asmundis, Carlo

Published
2023
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16. Heart rate variability and microvolt T wave alternans changes during ajmaline test may predict prognosis in Brugada syndrome

Author

Călburean, Paul-Adrian, Pannone, Luigi, Sorgente, Antonio, Gauthey, Anaïs, Monaco, Cinzia, Strazdas, Antanas, Almorad, Alexandre, Bisignani, Antonio, Bala, Gezim, Ramak, Robbert, Overeinder, Ingrid, Ströker, Erwin, Pappaert, Gudrun, Van Dooren, Sonia, de Ravel, Thomy, La Meir, Mark, Brugada, Pedro, Sieira, Juan, Chierchia, Gian-Battista, and de Asmundis, Carlo

Published
2023
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17. Genetics in Probands With Idiopathic Ventricular Fibrillation: A Multicenter Study

Author

Pannone, Luigi, Gauthey, Anaïs, Conte, Giulio, Osei, Randy, Campanale, Daniela, Baldi, Enrico, Berne, Paola, Vicentini, Alessandro, Vergara, Pasquale, Sorgente, Antonio, Rootwelt-Norberg, Christine, Della Rocca, Domenico Giovanni, Monaco, Cinzia, Bisignani, Antonio, Miraglia, Vincenzo, Spolverini, Marcello, Paparella, Gaetano, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, de Ravel, Thomy, Medeiros-Domingo, Argelia, Sieira, Juan, Haugaa, Kristina H., Brugada, Pedro, La Meir, Mark, Auricchio, Angelo, Chierchia, Gian-Battista, Van Dooren, Sonia, and de Asmundis, Carlo

Published
2023
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19. Clinical Management of Brugada Syndrome: Commentary From the Experts

Author

Cutler, Michael J., Eckhardt, Lee L., Kaufman, Elizabeth S., Arbelo, Elena, Behr, Elijah R., Brugada, Pedro, Cerrone, Marina, Crotti, Lia, deAsmundis, Carlo, Gollob, Michael H., Horie, Minoru, Huang, David T., Krahn, Andrew D., London, Barry, Lubitz, Steven A., Mackall, Judith A., Nademanee, Koonlawee, Perez, Marco V., Probst, Vincent, Roden, Dan M., Sacher, Frederic, Sarquella-Brugada, Georgia, Scheinman, Melvin M., Shimizu, Wataru, Shoemaker, Benjamin, Sy, Raymond W., Watanabe, Atsuyuki, and Wilde, Arthur A.M.

Published
2024
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21. Ventricular Tachycardia

Author

Hayase, Justin, Glover, Benedict M., Brugada, Pedro, Bradfield, Jason S., Glover, Benedict M., editor, and Brugada, Pedro, editor

Published
2021
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22. Atrial Flutter

Author

Hong, Kathryn L., Glover, Benedict M., Brugada, Pedro, Glover, Benedict M., editor, and Brugada, Pedro, editor

Published
2021
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23. Atrial Fibrillation

Author

Haissaguerre, Michel, Glover, Benedict M., Brugada, Pedro, Glover, Benedict M., editor, and Brugada, Pedro, editor

Published
2021
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24. Atrial Tachycardias

Author

Lee, Adam, Hsia, Henry H., Haqqani, Haris M., Glover, Benedict M., Brugada, Pedro, Scheinman, Melvin M., Glover, Benedict M., editor, and Brugada, Pedro, editor

Published
2021
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31. Targeted Treatment of Inappropriate Sinoatrial Node Tachycardia Based on Electrophysiological and Structural Mechanisms

Author

de Asmundis, Carlo, Pannone, Luigi, Lakkireddy, Dhanunjaya, Beaver, Thomas M., Brodt, Chad R., Lee, Randall J., Sorgente, Antonio, Gauthey, Anaïs, Monaco, Cinzia, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, Brugada, Pedro, Chierchia, Gian-Battista, La Meir, Mark, and Olshansky, Brian

Published
2022
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32. Hybrid-Approach Ablation in Drug-Refractory Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Monaco, Cinzia, Galli, Alessio, Pannone, Luigi, Bisignani, Antonio, Miraglia, Vincenzo, Gauthey, Anaïs, Al Housari, Maysam, Mojica, Joerelle, Del Monte, Alvise, Lipartiti, Felicia, Rizzi, Sergio, Mouram, Sahar, Calburean, Paul-Adrian, Ramark, Robbert, Pappaert, Gudrun, Eltsov, Ivan, Bala, Gezim, Sorgente, Antonio, Overeinder, Ingrid, Almorad, Alexandre, Stroker, Erwin, Sieira, Juan, Brugada, Pedro, Chierchia, Gian Battista, La Meir, Mark, and de Asmundis, Carlo

Published
2022
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33. Comparison between the novel diamond temp and the classical 8-mm tip ablation catheters in the setting of typical atrial flutter

Author

Ramak, Robbert, Lipartiti, Felicia, Mojica, Joerelle, Monaco, Cinzia, Bisignani, Antonio, Eltsov, Ivan, Sorgente, Antonio, Capulzini, Lucio, Paparella, Gaetano, Deruyter, Bernard, Iacopino, Saverio, Motoc, Andreea Iulia, Luchian, Maria Luiza, Osorio, Thiago Guimaraes, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, Jordaens, Luc, Brugada, Pedro, de Asmundis, Carlo, and Chierchia, Gian-Battista

Published
2022
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35. SCN5A mutation in Brugada syndrome is associated with substrate severity detected by electrocardiographic imaging and high-density electroanatomic mapping

Author

Pannone, Luigi, Monaco, Cinzia, Sorgente, Antonio, Vergara, Pasquale, Gauthey, Anaïs, Calburean, Paul-Adrian, Bisignani, Antonio, Paparella, Gaetano, Ramak, Robbert, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Pappaert, Gudrun, Sieira, Juan, Brugada, Pedro, Van Dooren, Sonia, de Ravel, Thomy, La Meir, Mark, Chierchia, Gian Battista, and de Asmundis, Carlo

Published
2022
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36. Single procedural outcomes in the setting of percutaneous ablation for persistent atrial fibrillation: a propensity-matched score comparison between different strategies

Author

Bisignani, Antonio, Cecchini, Federico, Mugnai, Giacomo, Overeinder, Ingrid, Sieira, Juan, Osório, Thiago Guimarães, Miraglia, Vincenzo, Monaco, Cinzia, Sofianos, Dimitrios, Boveda, Serge, Bala, Gezim, Ströker, Erwin, Paparella, Gaetano, Westra, Sjoerd W., Brouwer, Marc A., Brugada, Pedro, de Asmundis, Carlo, and Chierchia, Gian-Battista

Published
2022
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37. Sinus node sparing novel hybrid approach for treatment of inappropriate sinus tachycardia/postural sinus tachycardia: multicenter experience

Author

de Asmundis, Carlo, Chierchia, Gian-Battista, Lakkireddy, Dhanunjaya, Romeya, Ahmed, Okum, Eric, Gandhi, Gaurang, Sieira, Juan, Vloka, Margot, Jones, Stephen D., Shah, Hemal, Winner, Marshall, Patel, Dilesh, Whalen, S. Patrick, Beaty, Elijah H., Kincaid, Edward Hal, Lee, Anson, Brodt, Chad, Taylor, Benadict J., Colombowala, Ilyas, Romano, Matthew, Morady, Fred, Ströker, Erwin, Overeinder, Ingrid, Bala, Gezim, Van Meeteren, Justin, Krauthammer, Yoaav, Koerber, Scott, Shults, Christian, Thomaides, Athanasios, Badhwar, Nitish, Gopinathannair, Rakesh, Shah, Alap, Tummala, Rangarao, Bello, David, Hoff, Steve, Almorad, Alexandre, Frazier, Kenneth, Brugada, Pedro, and La Meir, Mark

Published
2022
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38. High-density epicardial mapping in Brugada syndrome: Depolarization and repolarization abnormalities

Author

Pannone, Luigi, Monaco, Cinzia, Sorgente, Antonio, Vergara, Pasquale, Calburean, Paul-Adrian, Gauthey, Anaïs, Bisignani, Antonio, Kazawa, Shuichiro, Strazdas, Antanas, Mojica, Joerelle, Lipartiti, Felicia, Al Housari, Maysam, Miraglia, Vincenzo, Rizzi, Sergio, Sofianos, Dimitrios, Cecchini, Federico, Osório, Thiago Guimarães, Paparella, Gaetano, Ramak, Robbert, Overeinder, Ingrid, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Pappaert, Gudrun, Sieira, Juan, Brugada, Pedro, La Meir, Mark, Chierchia, Gian Battista, and de Asmundis, Carlo

Published
2022
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39. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Author

Barc, Julien, Tadros, Rafik, Glinge, Charlotte, Chiang, David Y., Jouni, Mariam, Simonet, Floriane, Jurgens, Sean J., Baudic, Manon, Nicastro, Michele, Potet, Franck, Offerhaus, Joost A., Walsh, Roddy, Choi, Seung Hoan, Verkerk, Arie O., Mizusawa, Yuka, Anys, Soraya, Minois, Damien, Arnaud, Marine, Duchateau, Josselin, Wijeyeratne, Yanushi D., Muir, Alison, Papadakis, Michael, Castelletti, Silvia, Torchio, Margherita, Ortuño, Cristina Gil, Lacunza, Javier, Giachino, Daniela F., Cerrato, Natascia, Martins, Raphaël P., Campuzano, Oscar, Van Dooren, Sonia, Thollet, Aurélie, Kyndt, Florence, Mazzanti, Andrea, Clémenty, Nicolas, Bisson, Arnaud, Corveleyn, Anniek, Stallmeyer, Birgit, Dittmann, Sven, Saenen, Johan, Noël, Antoine, Honarbakhsh, Shohreh, Rudic, Boris, Marzak, Halim, Rowe, Matthew K., Federspiel, Claire, Le Page, Sophie, Placide, Leslie, Milhem, Antoine, Barajas-Martinez, Hector, Beckmann, Britt-Maria, Krapels, Ingrid P., Steinfurt, Johannes, Winkel, Bo Gregers, Jabbari, Reza, Shoemaker, Moore B., Boukens, Bas J., Škorić-Milosavljević, Doris, Bikker, Hennie, Manevy, Federico C., Lichtner, Peter, Ribasés, Marta, Meitinger, Thomas, Müller-Nurasyid, Martina, Veldink, Jan H., van den Berg, Leonard H., Van Damme, Philip, Cusi, Daniele, Lanzani, Chiara, Rigade, Sidwell, Charpentier, Eric, Baron, Estelle, Bonnaud, Stéphanie, Lecointe, Simon, Donnart, Audrey, Le Marec, Hervé, Chatel, Stéphanie, Karakachoff, Matilde, Bézieau, Stéphane, London, Barry, Tfelt-Hansen, Jacob, Roden, Dan, Odening, Katja E., Cerrone, Marina, Chinitz, Larry A., Volders, Paul G., van de Berg, Maarten P., Laurent, Gabriel, Faivre, Laurence, Antzelevitch, Charles, Kääb, Stefan, Arnaout, Alain Al, Dupuis, Jean-Marc, Pasquie, Jean-Luc, Billon, Olivier, Roberts, Jason D., Jesel, Laurence, Borggrefe, Martin, Lambiase, Pier D., Mansourati, Jacques, Loeys, Bart, Leenhardt, Antoine, Guicheney, Pascale, Maury, Philippe, Schulze-Bahr, Eric, Robyns, Tomas, Breckpot, Jeroen, Babuty, Dominique, Priori, Silvia G., Napolitano, Carlo, de Asmundis, Carlo, Brugada, Pedro, Brugada, Ramon, Arbelo, Elena, Brugada, Josep, Mabo, Philippe, Behar, Nathalie, Giustetto, Carla, Molina, Maria Sabater, Gimeno, Juan R., Hasdemir, Can, Schwartz, Peter J., Crotti, Lia, McKeown, Pascal P., Sharma, Sanjay, Behr, Elijah R., Haissaguerre, Michel, Sacher, Frédéric, Rooryck, Caroline, Tan, Hanno L., Remme, Carol A., Postema, Pieter G., Delmar, Mario, Ellinor, Patrick T., Lubitz, Steven A., Gourraud, Jean-Baptiste, Tanck, Michael W., George, Jr., Alfred L., MacRae, Calum A., Burridge, Paul W., Dina, Christian, Probst, Vincent, Wilde, Arthur A., Schott, Jean-Jacques, Redon, Richard, and Bezzina, Connie R.

Published
2022
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40. dST-Tiso Interval, a Novel Electrocardiographic Marker of Ventricular Arrhythmia Inducibility in Individuals With Ajmaline-Induced Brugada Type I Pattern

Author

Iacopino, Saverio, Chierchia, Gian-Battista, Sorrenti, Paolo, Pesce, Francesca, Colella, Jacopo, Fabiano, Gennaro, Campagna, Giuseppe, Petretta, Andrea, Placentino, Filippo, Filannino, Pasquale, Artale, Paolo, Giacopelli, Daniele, Santarpino, Giuseppe, Sorgente, Antonio, Brugada, Pedro, and de Asmundis, Carlo

Published
2021
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43. Substrate mapping of the left atrium in persistent atrial fibrillation: spatial correlation of localized complex conduction patterns in global charge-density maps to low-voltage areas in 3D contact bipolar voltage maps

Author

Chierchia, Gian-Battista, Sieira, Juan, Vanderper, Annelies, Osorio, Thiago Guimarães, Bala, Gezim, Stroker, Erwin, Brugada, Pedro, Al Houssari, Maysam, Cecchini, Federico, Mojica, Joerelle, Overeinder, Ingrid, Bisignani, Antonio, Mitraglia, Vincenzo, Boveda, Serge, Paparella, Gaetano, and de Asmundis, Carlo

Published
2021
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44. Comparison between superior vena cava ablation in addition to pulmonary vein isolation and standard pulmonary vein isolation in patients with paroxysmal atrial fibrillation with the cryoballoon technique

Author

Overeinder, Ingrid, Osório, Thiago Guimarães, Călburean, Paul-Adrian, Bisignani, Antonio, Bala, Gezim, Sieira, Juan, Ströker, Erwin, Al Houssari, Maysam, Mojica, Joerelle, Boveda, Serge, Paparella, Gaetano, Brugada, Pedro, de Asmundis, Carlo, and Chierchia, Gian-Battista

Published
2021
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48. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

Author

Walsh, Roddy, Lahrouchi, Najim, Tadros, Rafik, Kyndt, Florence, Glinge, Charlotte, Postema, Pieter G., Amin, Ahmad S., Nannenberg, Eline A., Ware, James S., Whiffin, Nicola, Mazzarotto, Francesco, Škorić-Milosavljević, Doris, Krijger, Christian, Arbelo, Elena, Babuty, Dominique, Barajas-Martinez, Hector, Beckmann, Britt M., Bézieau, Stéphane, Bos, J. Martijn, Breckpot, Jeroen, Campuzano, Oscar, Castelletti, Silvia, Celen, Candan, Clauss, Sebastian, Corveleyn, Anniek, Crotti, Lia, Dagradi, Federica, de Asmundis, Carlo, Denjoy, Isabelle, Dittmann, Sven, Ellinor, Patrick T., Ortuño, Cristina Gil, Giustetto, Carla, Gourraud, Jean-Baptiste, Hazeki, Daisuke, Horie, Minoru, Ishikawa, Taisuke, Itoh, Hideki, Kaneko, Yoshiaki, Kanters, Jørgen K., Kimoto, Hiroki, Kotta, Maria-Christina, Krapels, Ingrid P.C., Kurabayashi, Masahiko, Lazarte, Julieta, Leenhardt, Antoine, Loeys, Bart L., Lundin, Catarina, Makiyama, Takeru, Mansourati, Jacques, Martins, Raphaël P., Mazzanti, Andrea, Mörner, Stellan, Napolitano, Carlo, Ohkubo, Kimie, Papadakis, Michael, Rudic, Boris, Molina, Maria Sabater, Sacher, Frédéric, Sahin, Hatice, Sarquella-Brugada, Georgia, Sebastiano, Regina, Sharma, Sanjay, Sheppard, Mary N., Shimamoto, Keiko, Shoemaker, M.Benjamin, Stallmeyer, Birgit, Steinfurt, Johannes, Tanaka, Yuji, Tester, David J., Usuda, Keisuke, van der Zwaag, Paul A., Van Dooren, Sonia, Van Laer, Lut, Winbo, Annika, Winkel, Bo G., Yamagata, Kenichiro, Zumhagen, Sven, Volders, Paul G.A., Lubitz, Steven A., Antzelevitch, Charles, Platonov, Pyotr G., Odening, Katja E., Roden, Dan M., Roberts, Jason D., Skinner, Jonathan R., Tfelt-Hansen, Jacob, van den Berg, Maarten P., Olesen, Morten S., Lambiase, Pier D., Borggrefe, Martin, Hayashi, Kenshi, Rydberg, Annika, Nakajima, Tadashi, Yoshinaga, Masao, Saenen, Johan B., Kääb, Stefan, Brugada, Pedro, Robyns, Tomas, Giachino, Daniela F., Ackerman, Michael J., Brugada, Ramon, Brugada, Josep, Gimeno, Juan R., Hasdemir, Can, Guicheney, Pascale, Priori, Silvia G., Schulze-Bahr, Eric, Makita, Naomasa, Schwartz, Peter J., Shimizu, Wataru, Aiba, Takeshi, Schott, Jean-Jacques, Redon, Richard, Ohno, Seiko, Probst, Vincent, Arnaout, Alain Al, Amelot, Mathieu, Anselme, Frédéric, Billon, Olivier, Defaye, Pascal, Dupuis, Jean-Marc, Jesel, Laurence, Laurent, Gabriel, Maury, Philippe, Pasquie, Jean-Luc, Wiart, Francois, Behr, Elijah R., Barc, Julien, and Bezzina, Connie R.

Published
2021
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49. Posterior box isolation as an adjunctive ablation strategy with the second-generation cryoballoon for paroxysmal atrial fibrillation: a comparison with standard cryoballoon pulmonary vein isolation

Author

Bisignani, Antonio, Overeinder, Ingrid, Kazawa, Shuichiro, Iacopino, Saverio, Cecchini, Federico, Miraglia, Vincenzo, Osório, Thiago Guimarães, Boveda, Serge, Bala, Gezim, Mugnai, Giacomo, Monaco, Cinzia, Ströker, Erwin, Brugada, Pedro, Sieira, Juan, Galli, Alessio, de Asmundis, Carlo, and Chierchia, Gian Battista

Published
2021
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50. Distance‐dependent neuromodulation effect during thermal ablation for atrial fibrillation.

Author

Nakasone, Kazutaka, Tanaka, Kaoru, Del Monte, Alvise, Della Rocca, Domenico Giovanni, Pannone, Luigi, Mouram, Sahar, Cespón‐Fernández, María, Doundoulakis, Ioannis, Marcon, Lorenzo, Audiat, Charles, Vetta, Giampaolo, Scacciavillani, Roberto, Overeinder, Ingrid, Bala, Gezim, Sorgente, Antonio, Sieira, Juan, Almorad, Alexandre, Fukuzawa, Koji, Hirata, Ken‐ichi, and Brugada, Pedro

Subjects
INNERVATION of the heart, HEART anatomy, AUTONOMIC nervous system physiology, HEART rate monitoring, PULMONARY veins, COMPUTED tomography, VENA cava superior, SCIENTIFIC observation, RADIO frequency therapy, TREATMENT effectiveness, AGE distribution, HEART beat, COLD therapy, ELECTROCARDIOGRAPHY, ODDS ratio, ATRIAL fibrillation, AUTONOMIC ganglia, CATHETER ablation, CONFIDENCE intervals
Abstract

Introduction: Thermal atrial fibrillation (AF) ablation exerts an additive treatment effect on the cardiac autonomic nervous system (CANS). This effect is mainly reported during ablation of the right superior pulmonary vein (RSPV), modulating the right anterior ganglionated plexus (RAGP), which contains parasympathetic innervation to the sinoatrial node in the epicardial fat pad between RSPV and superior vena cava (SVC). However, a variable response to neuromodulation after ablation is observed, with little to no effect in some patients. Our objective was to assess clinical and anatomic predictors of thermal ablation‐induced CANS changes, as assessed via variations in heart rate (HR) postablation. Methods: Consecutive paroxysmal AF patients undergoing first‐time PV isolation by the cryoballoon (CB) or radiofrequency balloon (RFB) within a 12‐month time frame and with preprocedural cardiac computed tomography (CT), were evaluated. Preablation and 24‐h postablation electrocardiograms in sinus rhythm were collected and analyzed to assess HR. Anatomic evaluation by CT included the measurement of the shortest distance between the SVC and RSPV ostium (RSPV‐SVC distance). Results: A total of 97 patients (CB, n = 50 vs. RFB, n = 47) were included, with similar baseline characteristics between both groups. A significant HR increase postablation (ΔHR ≥ 15 bpm) occurred in a total of 37 patients (38.1%), without difference in number of patients between both thermal ablation technologies (CB, 19 [51%]), RFB, 18 [49%]). Independent predictors for increased HR were RSPV‐SVC distance (odds ratio [OR]: 0.49, CI: 0.34–0.71, p value <.001), and age (OR: 0.94, CI: 0.89–0.98, p value =.003). Conclusions: Thermal balloon‐based PV isolation influences the CANS through its effect on the RAGP, especially in younger patients and patients with shorter RSPV‐SVC distance. [ABSTRACT FROM AUTHOR]

Published
2024
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