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3. Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease : Pooled De Novo Results From 15 Observational Studies

Author

Laguzzi, F., Åkesson, A., Marklund, Matti, Qian, F., Gigante, B., Bartz, T. M., Bassett, J. K., Birukov, A., Campos, H., Hirakawa, Y., Imamura, F., Jäger, S., Lankinen, M., Murphy, R. A., Senn, M., Tanaka, T., Tintle, N., Virtanen, J. K., Yamagishi, K., Allison, M., Brouwer, I. A., De Faire, U., Eiriksdottir, G., Ferrucci, L., Forouhi, N. G., Geleijnse, J. M., Hodge, A. M., Kimura, H., Laakso, M., Risérus, Ulf, van Westing, A. C., Bandinelli, S., Baylin, A., Giles, G. G., Gudnason, V., Iso, H., Lemaitre, R. N., Ninomiya, T., Post, W. S., Psaty, B. M., Salonen, J. T., Schulze, M. B., Tsai, M. Y., Uusitupa, M., Wareham, N. J., Oh, S.-W., Wood, A. C., Harris, W. S., Siscovick, D., Mozaffarian, D., Leander, K., Laguzzi, F., Åkesson, A., Marklund, Matti, Qian, F., Gigante, B., Bartz, T. M., Bassett, J. K., Birukov, A., Campos, H., Hirakawa, Y., Imamura, F., Jäger, S., Lankinen, M., Murphy, R. A., Senn, M., Tanaka, T., Tintle, N., Virtanen, J. K., Yamagishi, K., Allison, M., Brouwer, I. A., De Faire, U., Eiriksdottir, G., Ferrucci, L., Forouhi, N. G., Geleijnse, J. M., Hodge, A. M., Kimura, H., Laakso, M., Risérus, Ulf, van Westing, A. C., Bandinelli, S., Baylin, A., Giles, G. G., Gudnason, V., Iso, H., Lemaitre, R. N., Ninomiya, T., Post, W. S., Psaty, B. M., Salonen, J. T., Schulze, M. B., Tsai, M. Y., Uusitupa, M., Wareham, N. J., Oh, S.-W., Wood, A. C., Harris, W. S., Siscovick, D., Mozaffarian, D., and Leander, K.

Abstract

BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions. CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.

Published
2024
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4. Multimodal MRI study on the relation between WM integrity and connected GM atrophy and its effect on disability in early multiple sclerosis

Author

Weeda, Merlin M., primary, van Nederpelt, D. R., additional, Twisk, J. W. R., additional, Brouwer, I., additional, Kuijer, J. P. A., additional, van Dam, M., additional, Hulst, H. E., additional, Killestein, J., additional, Barkhof, F., additional, Vrenken, H., additional, and Pouwels, P. J. W., additional

Published
2023
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8. Vitamin B.sub.12, homocysteine and depressive symptoms: a longitudinal study among older adults

Author

Elstgeest, L E M, Brouwer, I A, Penninx, B WJ H, van Schoor, N M, and Visser, M

Subjects
Aged -- Psychological aspects -- Health aspects -- Food and nutrition, Depression in old age -- Risk factors -- Diagnosis, Vitamin B12 -- Health aspects -- Psychological aspects, Homocysteine -- Health aspects -- Psychological aspects, Food/cooking/nutrition, Health
Abstract

Background/Objectives: The roles of vitamin B.sub.12 and homocysteine concentration in depression are not clear. We investigated cross-sectional and prospective associations of serum vitamin B.sub.12 and plasma homocysteine with depressive symptoms in Dutch older adults. Subjects/Methods: In the Longitudinal Aging Study Amsterdam (LASA), blood was collected in 1995/1996 among 1352 men and women aged [greater-than or slanted equal to]65 years. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) six times from 1995/1996 to 2011/2012. Multiple linear regression and mixed models were used to assess whether vitamin B.sub.12 and homocysteine were associated with severity at baseline and course of depressive symptoms over 16 years. Cox regression analyses were performed for the associations with incidence of depression (CES-D [greater-than or slanted equal to]16 and/or antidepressant use). All analyses were adjusted for sociodemographic characteristics and lifestyle factors. Results: Vitamin B.sub.12 was neither cross-sectionally (n=1205) nor prospectively (n=1012) associated with depressive symptoms (adjusted [beta] for CES-D over time, lowest versus highest quartile: -0.04 (95% confidence interval (CI): -0.15-0.06)). We also found no association with incident depression (n=853), except for a higher risk of depression over time in younger participants (aged 64.8-73.4 years; continuous vitamin B12, adjusted hazard ratio per s.d.: 1.38 (95% CI: 1.10-1.72)). For homocysteine, no associations were found, except for a lower risk of depression in younger participants. Conclusions: Our study did not confirm earlier shown associations of serum vitamin B.sub.12 and plasma homocysteine with severity and course of depressive symptoms and incidence of depression in older adults. Further research into the influence of homocysteine metabolism on mental health is needed., Author(s): L E M Elstgeest [sup.1] , I A Brouwer [sup.1] , B WJ H Penninx [sup.2] , N M van Schoor [sup.3] , M Visser [sup.1] [sup.4] Author Affiliations: [...]

Published
2017
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10. The MooDFOOD project: Prevention of depression through nutritional strategies

Author

Cabout, M., Brouwer, I. A., Visser, M., van Strien, Tatjana, Elstgeest, Liset, Winkens, Laura, Bektas, Gülcan, Doncker, Sarah, Brunner, Eric, Knüppel, Anika, Gunnarsdottir, Ingibjorg, Gudnason, Vilmundur, Imai, Cindy M., Halldorsson, Thorhallur Ingi, Birgisdottir, Bryndis Eva, Aspelund, Thor, Nicolaou, Mary, Vermeulen, Esther, Lähteenmäki, Liisa, Loebnitz, Natascha, Toft, Madeleine Broman, Tudoran, Ana Alina, Pederson, Susanne, Friis, Rasmus, Penninx, Brenda, van Grootheest, Gerard, Verkerk, Bep, Watkins, Ed, Owens, Matthew, Romijn, Amy, Bunce, Hannah, Bunker‐Smith, Harriet, Durbridge, Fern, Winfield, Owain, Bond, Zenia, Molinares, Caterina Versari, Sapar, Atikah, Roca, Miquel, Gili, Margarita, Tortella, Miquel, Covas, Clara Homar, Forteza, Margalida Vives, Gracia, Adoración Castro, Reig, José Luis, Ara, Maria Angeles Pérez, Hegerl, Ulrich, Kohls, Elisabeth, Hoesel, Jana, Dogan, Ezgi, Baldofski, Sabrina, Mauche, Nicole, Bot, Mariska, Milaneschi, Yuri, Paans, Nadine, Thesing, Carisha, Gibson‐Smith, Deborah, Horsfall, Melany, Weiss, Lena, Bandinelli, Stefania, Colpo, Marco, Sini, Giovanna, Woodward, Euan, Bryant, Sheree, van Eijcken, Erik, and Marking, Christine

Published
2017
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12. Nutrition and depression: Summary of findings from the EU‐funded MooDFOOD depression prevention randomised controlled trial and a critical review of the literature

Author

Owens, M., Watkins, E., Bot, M., Brouwer, I. A., Roca, M., Kohls, E., Penninx, B. W. J. H., van Grootheest, G., Hegerl, U., Gili, M., Visser, M., MooDFOOD Prevention Trial, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, AGEM - Endocrinology, metabolism and nutrition, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, APH - Digital Health, Health Sciences, Nutrition and Health, and APH - Societal Participation & Health

Subjects
0301 basic medicine, medicine.medical_specialty, Psychological intervention, Medicine (miscellaneous), 030209 endocrinology & metabolism, Overweight, law.invention, supplements, 03 medical and health sciences, 0302 clinical medicine, Extant taxon, Randomized controlled trial, nutrients, law, medicine, Depression prevention, SDG 2 - Zero Hunger, Psychiatry, Depression (differential diagnoses), 030109 nutrition & dietetics, Nutrition and Dietetics, omega-3 fatty acids, business.industry, Mild symptoms, depression, medicine.symptom, diet, business, Psychopathology
Abstract

This paper discusses the emerging field of nutritional psychology and provides an update on the now completed EU-fundedMooDFOODdepression prevention randomised controlled trial that assessed the effects of two nutrition-based interventions for the prevention of depression in overweight or obese adults with at least mild symptoms of depression. We first outline the problem of major depression, the most common form of psychopathology and the largest contributor to global disability, and then give an overview of the connection between nutrition and depression; separating the evidence according to prevention and treatment of depression. The extant literature is reviewed, and we examine the implications for both prevention and treatment. Questions are posed for further research in this emerging and important area., This work was supported by the European Union FP7 MooDFOOD Project 'Multi-country cOllaborative project on the rOle of Diet, FOod related behaviour, and Obesity in the prevention of Depression' (grant agreement no. 613598). This work is supported in the UK by the National Institute for Health Research (NIHR), through the Primary Care Research Network and the NIHR Exeter Clinical Research Facility. Further information, including advice for health professionals, can be found here (www.moodfood.eu).

Published
2020

13. End Unexplained Cardiac Death (EndUCD) NSW Registry: A Data Linkage Cohort Study Protocol

Author

Leslie, F., primary, Avis, S., additional, Bagnall, R., additional, Bendall, J., additional, Briffa, T., additional, Brouwer, I., additional, Butters, A., additional, Figtree, G., additional, La Gerche, A., additional, van Heusden, A., additional, Nedkoff, L., additional, Paratz, E., additional, Semsarian, C., additional, Sy, R., additional, du Toit-Prinsloo, L., additional, Sweeting, J., additional, and Ingles, J., additional

Published
2022
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17. Maternal early-pregnancy vitamin D status in relation to linear growth at the age of 5-6 years: results of the ABCD cohort

Author

van Eijsden, M., Snijder, M.B, Brouwer, I., and Vrijkotte, T.G.M.

Subjects
Pregnancy -- Physiological aspects -- Health aspects, Fetus -- Growth, Alfacalcidol -- Physiological aspects -- Health aspects, Calcifediol -- Physiological aspects -- Health aspects, Vitamin D -- Physiological aspects -- Health aspects, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: Low vitamin D status during pregnancy may be associated with infant skeletal growth. However, evidence on the longer-term effect is limited. This study aims to assess the association between maternal vitamin D status in early pregnancy and markers of linear growth (height, leg length and relative leg length) of the child at age 5-6 years. SUBJECTS/METHODS: A subsample of data from the Amsterdam Born Children and Development (ABCD) study was used. Ethnic Dutch pregnant women and their children (n = 1208) were included. Maternal serum vitamin D level was determined at first antenatal visit (median 13 weeks, interquartile range: 12-14). We investigated the association of maternal vitamin D, corrected for season, with height, leg length and relative leg length at age 5-6 years. RESULTS: Linear regression analyses showed no significant association between maternal vitamin D levels (nmol/l) and height (cm) (B = -0.006; P = 0.205), leg length (cm) (B = - 0.002, P = 0.540) or relative leg length (%) (B = 0.001; P = 0.579). Adjustment for potential confounders (parental heights, maternal educational level, alcohol use during pregnancy, child sex, child age at measurement and child screen time) did not change these results. CONCLUSIONS: Maternal vitamin D level was not associated with early linear growth in children. Other factors, such as parental height, appear to be more important. European Journal of Clinical Nutrition (2013) 67, 972-977; doi: 10.1038/ejcn.2013.106; published online 12 June 2013 Keywords: vitamin D; pregnancy; growth; ABCD study, INTRODUCTION Vitamin D is a prohormone that can be obtained from dietary sources and through endogenous skin synthesis after exposure to ultraviolet sunlight. Environmental factors that alter the action of [...]

Published
2013
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20. The sequence of structural, functional and cognitive changes in multiple sclerosis

Author

Dekker, I (Iris), Schoonheim, MM, Venkatraghavan, Vikram, Eijlers, AJC, Brouwer, I, Bron, Esther, Klein, Stefan, Wattjes, MP, Wink, A M, Geurts, JJG, Uitdehaag, BM, Oxtoby, NP, Alexander, DC, Vrenken, H, Killestein, J, Barkhof, F, Wottschel, V, Dekker, I (Iris), Schoonheim, MM, Venkatraghavan, Vikram, Eijlers, AJC, Brouwer, I, Bron, Esther, Klein, Stefan, Wattjes, MP, Wink, A M, Geurts, JJG, Uitdehaag, BM, Oxtoby, NP, Alexander, DC, Vrenken, H, Killestein, J, Barkhof, F, and Wottschel, V

Abstract

Background: As disease progression remains poorly understood in multiple sclerosis (MS), we aim to investigate the sequence in which different disease milestones occur using a novel data-driven approach. Methods: We analysed a cohort of 295 relapse-onset MS patients and 96 healthy controls, and considered 28 features, capturing information on T2-lesion load, regional brain and spinal cord volumes, resting-state functional centrality (“hubness”), microstructural tissue integrity of major white matter (WM) tracts and performance on multiple cognitive tests. We used a discriminative event-based model to estimate the sequence of biomarker abnormality in MS progression in general, as well as specific models for worsening physical disability and cognitive impairment. Results: We demonstrated that grey matter (GM) atrophy of the cerebellum, thalamus, and changes in corticospinal tracts are early events in MS pathology, whereas other WM tracts as well as the cognitive domains of working memory, attention, and executive function are consistently late events. The models for disability and cognition show early functional changes of the default-mode network and earlier changes in spinal cord volume compared to the general MS population. Overall, GM atrophy seems crucial due to its early involvement in the disease course, whereas WM tract integrity appears to be affected relatively late despite the early onset of WM lesions. Conclusion: Data-driven modelling revealed the relative occurrence of both imaging and non-imaging events as MS progresses, providing insights into disease propagation mechanisms, and allowing fine-grained staging of patients for monitoring purposes

Published
2021

26. Facing privacy in neuroimaging:removing facial features degrades performance of image analysis methods

Author

de Sitter, A, Visser, M, Brouwer, I, Cover, K S, van Schijndel, R A, Eijgelaar, R S, Müller, D M J, Ropele, S, Kappos, L, Rovira, Á, Filippi, M, Enzinger, C, Frederiksen, J, Ciccarelli, O, Guttmann, C R G, Wattjes, M P, Witte, M G, de Witt Hamer, P C, Barkhof, F, Vrenken, H, de Sitter, A, Visser, M, Brouwer, I, Cover, K S, van Schijndel, R A, Eijgelaar, R S, Müller, D M J, Ropele, S, Kappos, L, Rovira, Á, Filippi, M, Enzinger, C, Frederiksen, J, Ciccarelli, O, Guttmann, C R G, Wattjes, M P, Witte, M G, de Witt Hamer, P C, Barkhof, F, and Vrenken, H

Abstract

BACKGROUND: Recent studies have created awareness that facial features can be reconstructed from high-resolution MRI. Therefore, data sharing in neuroimaging requires special attention to protect participants' privacy. Facial features removal (FFR) could alleviate these concerns. We assessed the impact of three FFR methods on subsequent automated image analysis to obtain clinically relevant outcome measurements in three clinical groups.METHODS: FFR was performed using QuickShear, FaceMasking, and Defacing. In 110 subjects of Alzheimer's Disease Neuroimaging Initiative, normalized brain volumes (NBV) were measured by SIENAX. In 70 multiple sclerosis patients of the MAGNIMS Study Group, lesion volumes (WMLV) were measured by lesion prediction algorithm in lesion segmentation toolbox. In 84 glioblastoma patients of the PICTURE Study Group, tumor volumes (GBV) were measured by BraTumIA. Failed analyses on FFR-processed images were recorded. Only cases in which all image analyses completed successfully were analyzed. Differences between outcomes obtained from FFR-processed and full images were assessed, by quantifying the intra-class correlation coefficient (ICC) for absolute agreement and by testing for systematic differences using paired t tests.RESULTS: Automated analysis methods failed in 0-19% of cases in FFR-processed images versus 0-2% of cases in full images. ICC for absolute agreement ranged from 0.312 (GBV after FaceMasking) to 0.998 (WMLV after Defacing). FaceMasking yielded higher NBV (p = 0.003) and WMLV (p ≤ 0.001). GBV was lower after QuickShear and Defacing (both p < 0.001).CONCLUSIONS: All three outcome measures were affected differently by FFR, including failure of analysis methods and both "random" variation and systematic differences. Further study is warranted to ensure high-quality neuroimaging research while protecting participants' privacy.KEY POINTS: • Protecting participants' privacy when sharing MRI data is imp

Published
2020

27. Does food intake mediate the association between mindful eating and change in depressive symptoms?

Author

Winkens, Laura, Elstgeest, Liset, van Strien, T, Penninx, Bwjh, Visser, M, Brouwer, I A, Winkens, Laura, Elstgeest, Liset, van Strien, T, Penninx, Bwjh, Visser, M, and Brouwer, I A

Abstract

OBJECTIVE: To examine mediation by (i) diet quality and (ii) diet quantity in the associations of mindful eating domains with 3-year change in depressive symptoms.DESIGN: Depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale at baseline and 3-year follow-up. Four mindful eating domains (Focused Eating; Eating in response to Hunger and Satiety Cues; Eating with Awareness; Eating without Distraction) were measured with the Mindful Eating Behavior Scale. Food intake was measured with a 238-item FFQ. Diet quality was defined as the Mediterranean Diet Score (MDS). Diet quantity was defined as total energy intake (kcal/d; 1 kcal = 4·184 kJ). Mediation analyses with percentile-corrected bootstrap confidence intervals were conducted to calculate indirect effects.SETTING: Longitudinal Aging Study Amsterdam.PARTICIPANTS: Adults aged 55 years or above (n 929).RESULTS: Diet quality (MDS) did not mediate associations of any of the four mindful eating domains with change in depressive symptoms. In contrast, total energy intake did mediate the associations with change in depressive symptoms for the mindful eating domains Eating with Awareness (indirect effects fully adjusted models: B = -0·014, 95 % CI -0·037, -0·002) and Eating without Distraction (B = -0·013, 95 % CI -0·033, -0·001), but not for the other two domains. Post hoc multiple mediation analyses showed similar results.CONCLUSIONS: Higher scores on two mindful eating domains were associated with a decrease in depressive symptoms through lower total energy intake. Diet quantity, but not diet quality, could be a possible underlying mechanism in the associations between mindful eating and change in depressive symptoms.

Published
2020
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34. Thalamus atrophy progresses faster in subjects with early MS who have more damage in the connected white matter and who show increasing disability over time

Author

Weeda, M. M., Pruis, I. J., Brouwer, I., Bellenberg, B., Schneider, R., Lukas, C., Barkhof, F., Vrenken, H., Pouwels, P. J. W., Radiology and nuclear medicine, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, and Amsterdam Neuroscience - Neurodegeneration

Published
2019

35. Temporal ordering of multimodal biomarker abnormality in multiple sclerosis

Author

Dekker, I., Schoonheim, M. M., Venkatraghavan, V., Eijlers, A. J. C., Brouwer, I., Wattjes, M. P., Wink, A. M., Geurts, J. J. G., Uitdehaag, B. M. J., Oxtoby, N. P., Vrenken, H., Killestein, J., Barkhof, F., Wottschel, V., Radiology and nuclear medicine, Anatomy and neurosciences, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, Other Research, Amsterdam Neuroscience - Neurodegeneration, Neurology, AII - Inflammatory diseases, and Amsterdam Neuroscience - Cellular & Molecular Mechanisms

Published
2019

36. Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality

Author

MARKLUND, M., WU, J. H. Y., IMAMURA, F., DEL GOBBO, L. C., FRETTS, A., DE GOEDE, J., Shi, P., TINTLE, N., WENNBERG, M., ASLIBEKYAN, S., CHEN, T. A., DE OLIVEIRA OTTO, M. C., Hirakawa, Y., ERIKSEN, H. H., KROGER, J., LAGUZZI, F., LANKINEN, M., Murphy, R. A., PREM, K., Samieri, C., Virtanen, J., WOOD, A. C., Wong, K., YANG, W. S., Zhou, X., BAYLIN, A., BOER, J. M. A., BROUWER, I. A., Campos, H., CHAVES, P. H. M., CHIEN, K. L., DE FAIRE, U., DJOUSSE, L., EIRIKSDOTTIR, G., EL-ABBADI, N., FOROUHI, N. G., MICHAEL GAZIANO, J., GELEIJNSE, J. M., GIGANTE, B., GILES, G., GUALLAR, E., GUDNASON, V., HARRIS, T., HARRIS, W. S., Helmer, Catherine, HELLENIUS, M. L., Hodge, A., Hu, F. B., JACQUES, P. F., JANSSON, J. H., Kalsbeek, A., Khaw, K. T., Koh, W. P., Laakso, M., LEANDER, K., LIN, H. J., LIND, L., LUBEN, R., Luo, J., MCKNIGHT, B., MURSU, J., Ninomiya, T., Overvad, K., PSATY, B. M., RIMM, E., SCHULZE, M. B., SISCOVICK, D., SKJELBO NIELSEN, M., SMITH, A. V., STEFFEN, B. T., STEFFEN, L., Sun, Q., SUNDSTROM, J., TSAI, M. Y., TUNSTALL-PEDOE, H., UUSITUPA, M. I. J., VAN DAM, R. M., VEENSTRA, J., MONIQUE VERSCHUREN, W. M., Wareham, N., WILLETT, W., Woodward, M., Yuan, J. M., Micha, R., LEMAITRE, R. N., Mozaffarian, D., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, LEHA
Abstract

International audience; BACKGROUND: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform international recommendations, we evaluated how in vivo circulating and tissue levels of linoleic acid (LA) and arachidonic acid (AA) relate to incident cardiovascular disease (CVD) across multiple international studies. METHODS: We performed harmonized, de novo, individual-level analyses in a global consortium of 30 prospective observational studies from 13 countries. Multivariable-adjusted associations of circulating and adipose tissue LA and AA biomarkers with incident total CVD and subtypes (coronary heart disease (CHD), ischemic stroke, cardiovascular mortality) were investigated according to a prespecified analytical plan. Levels of LA and AA, measured as % of total fatty acids, were evaluated linearly according to their interquintile range (i.e., the range between the mid-point of the first and fifth quintiles), and categorically by quintiles. Study-specific results were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by age, sex, race, diabetes, statin use, aspirin use, omega-3 levels, and fatty acid desaturase 1 genotype (when available). RESULTS: In 30 prospective studies with medians of follow-up ranging 2.5 to 31.9 years, 15,198 incident cardiovascular events occurred among 68,659 participants. Higher levels of LA were significantly associated with lower risks of total CVD, cardiovascular mortality, and ischemic stroke, with hazard ratios per interquintile range of 0.93 (95% CI: 0.88-0.99), 0.78 (0.70-0.85), and 0.88 (0.79-0.98), respectively, and nonsignificantly with lower CHD risk (0.94; 0.88-1.00). Relationships were similar for LA evaluated across quintiles. AA levels were not associated with higher risk of cardiovascular outcomes; comparing extreme quintiles, higher levels were associated with lower risk of total CVD (0.92; 0.86-0.99). No consistent heterogeneity by population subgroups was identified in the observed relationships. CONCLUSIONS: In pooled global analyses, higher in vivo circulating and tissue levels of LA and possibly AA were associated with lower risk of major cardiovascular events. These results support a favorable role for LA in CVD prevention.

Published
2019

37. Royal academy of medicine in Ireland international conference on homocysteine metabolism from basic science to clinical medicine: Proceedings of meeting held at Dromoland Castle, Co. Clare on July 2nd–6th, 1995

Author

Björkegren, K., Bergmark, C., de Faire, U., Mansoor, M. Azam, Svardal, A., Bostom, A. G., Roubenoff, R., Dellaripa, P., Nadeau, M. R., Sutherland, P., Wilson, P. W. F., Jacques, P. F., Selhub, J., Rosenberg, I. H., Bostom, A. G., Brosnan, J. T., Hall, B., Nadeau, M. R., Selhub, J., Bostom, A. G., Shemin, D., Lapane, K. L., Sutherland, P., Nadeau, M. R., Wilson, P. W. F., Selhub, J., Bostom, A. G., Shemin, D., Nadeau, M. R., Selhub, J., Bostom, A. G., Selhub, J., Jacques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., Cuskelly, G. J., McNulty, H., Strain, J. J., McPartlin, J. M., Scott, J. M., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Coudé, M., Aral, B., Zabot, M. T., Aupetit, J., Kamoun, P., Chadefaux-Vekemans, B., Calaf, R., Ghiringelli, O., Barlatier, A., Charpiot, P., Rolland, P. H., Garçon, D., Charpiot, P., Augier, T., Chareyre, C., Rolland, P. H., Garçon, D., Chango, A., Hodez, F., Tronel, H., Nuel, G., Michel, F., Frémont, S., Méjean, L., Nicolas, J. P., Candito, M., Chambon, P., Gibelin, P., Amsellem, J., Baudouy, M., Morand, P., Candito, M., Chambon, P., Pringuey, D., Aubin-Brunet, V., Beaulieu, F., Darcourt, G., Bedoucha, P., Alchaar, H., Chatel, M., Candito, M., de Valk, H. W., van der Griend, R., Eeden, M. K. G. van, de Groot, E., Duran, M., Smeitink, J. A. M., de Klerk, J. B. C., Wittebol-Post, D., Rolland, M. -O., Haas, F. J. L. M., Meuwissen, O. J. A. Th., Banga, J. D., Poll-The, B. T., de Vries, J. I. P., Dekker, G. A., van Geijn, H. P., Huigens, P. C., Jakobs, C., von Blomberg, B. M. E., Deulofeu, R., Giralt, M., Aibar, C., Bauchet, C., Ballesta, A. M., Varela, G., Vila, N., Chamorro, A., Casals, F. J., Cremades, J. Diaz, Daly, L., Meleady, R., Graham, I., den Heijer, M., Brouwer, I. A., Gerrits, W. B. J., Bos, G. M. J., Blom, H. J., den Heijer, M., Bos, G. M. J., Koster, T., Vandenbroucke, J. P., Blom, H. J., Briët, E., Rosendaal, F. R., Fischer, G., Behrend, C., Bartholmes, P., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Franken, D. G., Boers, G. H. J., Blom, H. J., Hamel, B. C. J., Franken, D. G., Boers, G. H. J., Blom, H. J., Ruijs, J. H. J., Franken, D. G., Blom, H. J., Boers, G. H. J., Tangerman, A., Guttormsen, A. B., Ueland, P. M., Refsum, H., Svarstad, E., Gao, W., Goldman, E., Jakubowski, H., Sebastio, G., Sperandeo, M. P., de Franchis, R., Andria, G., Garrow, T. A., Hladovec, J., Sommerova, Z., Písariková, A., Halsted, C. H., Villanueva, J., Chandler, C. J., Stabler, S. P., Allen, R. H., Muskhelishvili, L., James, S. J., Poirer, L., Jacobsen, D. W., Savon, S. R., DiCorleto, P. E., Jourdheuil-Rahmani, D., Rolland, P. H., Garçon, D., Joosten, E., Riezler, R., Allen, R., Joosten, E., Riezler, R., Allen, R., Marquardt, T., Ullrich, K., Harms, E., Koch, H. G., Koch, H. G., Evers, S., Grotemeyer, K. H., Vogelpohl, L., von Eckardstein, A., Ullrich, K., Deufel, T., Kraus, J., Harms, E., Kozich, V., Janosik, M., Sokolová, J., Bukovská, G., Kraus, J. P., Kluitmans, L. A. J., van den Heuvel, L. P., Stevens, E., Trubels, J. M. F., Blom, H. J., Boers, G. H. J., van Oost, B. A., Kraus, J. P., Kittner, S., Macko, R., Hebel, J. R., Rohr, J., Malinow, M. R., Upson, B., Buchholz, D., Earley, C., Johnson, C., Price, T. R., Rosario, J., Sloan, M., Stern, B., Wityk, R., Wozniak, M., Sherwin, R., Stolley, P., Kluijtmans, L., Heuvel, L. van den, Stevens, E., Trijbels, F., Blom, H., Boers, G., van Oost, B., den Heijer, M., Rozen, R., Löhrer, F., Angst, C., Fowler, B., Zaugg, M., Brunner, F., Haefeli, W. E., Nedrebø, B., Ericsson, U. -B., Ueland, P. M., Refsum, H., Lien, E. A., London, J., Paly, E., Paul, V., Paris, D., Kamoun, P., Chassé, J. F., Møller, J., Rasmussen, K., Meleady, R., Graham, I., Daly, L., Verhoef, P., Meleady, R., Graham, I., Daly, L., McMartin, K. E., Phifer, T. J., Alexander, J. S., Middlebrooks, M., Childress, L. E., Nicolas, J. P., Tronel, H., Chango, A., Fremont, S., Felden, F., Guerci, B., Creton, C., Drouin, P., Oakley, G. P., Elias, P. R. P., Hann, A. C., Curtis, C. G., Rose, F. A., Tudball, N., Parrot-Roulaud, F., Cochet, C., Catargi, B., Leprat, F., Latapie, J. -L., Perna, A. F., De Santo, N. G., Ingrosso, D., Galletti, P., Zappia, V., Parrot-Roulaud, F., Sassoust, G., Boissieras, P., Blom, H. J., Majors, A. K., Ehrhart, L. A., Pezacka, E. H., Perry, I. J., Morris, R. W., Ebrahim, S. B., Shaper, A. G., Refsum, H., Ueland, P. M., Pietrzik, K., Dierkes, J., Kroesen, M., Bung, P., Rasmussen, K., Moller, J., Rasmussen, K., Remacha, A., Garcia-Die, F., Cadafalch, J., Barceló, H. J., Parellada, H., Regland, B., Gottfries, C. -G., Andersson, M., Bagby, J., Dyrehag, L. -E., Abrahamsson, L., Ronge, E., Kjellman, B., Frosst, P., Christensen, B., Goyette, P., Rosenblatt, D. S., Genest, J., Rozen, R., Riedel, B., Ueland, P. M., Svardal, A. M., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X., Xie, L., Dudman, N., Smith, B., Kohlman-Trigoboff, D., Simsir, S., Stabler, S. P., Allen, R. H., Strydom, A. J. C., Schlüssel, E., Preibisch, G., Elstner, E. F. E., Pütter, S., Spuijbroek, M. D. E. H., Goddijn-Wessel, T. A. W., Wouters, M. G. A. J., Molen, E. F. v. d., Blom, H. J., Boers, G. H. J., Steegers-Theunissen, R. P. M., Trijbels, J. M. F., Thomas, C. M. G., Eskes, T. K. A. B., Tsai, M. Y., Hanson, N., Key, N., Schwichtenberg, K., Garg, U., Todesco, L., Fowler, B., Pollaert, N., Haefeli, W. E., Thorand, B., Hages, M., Pietrzik, K., Bung, P., Holzgreve, W., Vila, N., Chamorro, A., Deulofeu, R., Aibar, C., Giralt, M., Ballesta, A. M., van der Mooren, M. J., Wouters, M. G. A. J., Schellekens, L. A., Eskes, T. K. A. B., Rolland, R., Blom, H. J., Put, N. v. d., Trijbels, F., Heuvel, L. v. d., Blom, H., Eskes, T., Steegers-Theunissen, R., Mariman, E., Heyer, M. d., Rozen, R., Daher, R., Van Lente, F., Vilkovsky, A. B., Maev, I. V., Richter, E. L., Kirnus, M. D., Varela-Moreiras, G., Alonso-Aperte, E., Rubio, M., Gassó, M., Deulofeu, R., Alvarez, L., Caballeria, J., Rodés, J., Mato, J. M., van Aerts, L. A. G. J. M., Peereboom-Stegeman, J. H. J. Copius, Noordhoek, J., Eskes, T. K. A. B., Molen, E. F. v. d., Spuijbroek, M. D. E. H., Eskes, T. K. A. B., Heuvel, L. P. v. d., Monnens, L. A. H., Blom, H. J., van Guidener, C., Janssen, M. J. F. M., Surachno, J., Stehouwer, C. D. A., van den Berg, M., Bierdrager, E., Rauwerda, J. A., Wilcken, B., Hammond, J., Wouters, M. G. A. J., Hamilton, C. J. C. M., Blom, H. J., Boers, G. H. J., Thomas, C. M. G., Borm, G. F., Eskes, T. K. A. B., Wang, H., Tsai, J. -C., Perrella, M. A., Yoshizumi, M., Sibinga, N. E. S., Haber, E., Chang, T. H. -T., Schlegel, R., Lee, M. -E., Woodside, J., McMaster, D., Yarnell, J., Young, I., Mercer, C., Byrne, K., Evans, A., Gey, F., Gao, X. M., Dougan, G., Wordsworth, P., McMichael, A., Young, P. B., Kennedy, D. G., Molloy, A. M., Scott, J. M., Ward, P., Naughten, E., Cahalane, S., Murphy, D., Mayne, P., Chauveau, P., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Jungers, P., van Asselt, D. Z. B., Blom, H. J., de Wild, G. M., van Staveren, W. A., Hoefnagels, W. H. L., Naruszewicz, M., Staniewicz, A., Dziewanowski, K., Evrovski, J., Cole, D. E. C., Callaghan, Michael, Lindgren, A., Brattström, L., Hultberg, B., Verhoef, P., Hennekens, C. H., Allen, R. H., Stabler, S. P., Willett, W. C., Stampfer, M. J., Frantzen, F., Sundrehagen, E., Verhoef, P., Kok, F. J., Stampfer, M. J., Willett, W. C., Gaziano, J. M., Hennekens, C. H., Allen, R. H., Stabler, S. P., Reynolds, R. D., Hsu, R. -J., Shane, B., Robinson, K., Kottke-Marchant, K., Green, R., Gupta, A., Jacobsen, D., Robinson, K., Mayer, E., Gupta, A., Miller, D., Marchant, K., Green, R., Jacobsen, D., Greene, R., Chong, Y. -Y., Jacobsen, D., Robinson, K., Gupta, M., Sheppard, C. A., Matthews, R. G., Goyette, P., Frosst, P., Rozen, R., Verhoef, P., Kok, F. J., Kruyssen, H. A. C. M., Witteman, J. C. M., Ueland, P. M., Boushey, C., Beresford, S., Omenn, G., Motulsky, A. G., Nygard, O., Vollset, S. E., Kvale, G., Stensvold, I., Ueland, P. M., Refsum, H., Fiskerstrand, T., Ueland, P. M., Refsum, H., Bugge, K. H., Oshaug, A., Bjønnes, C. H., Refsum, H., Wu, J. T., Wu, L. L., and Wilson, L. W.

Published
1995
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40. Mindful eating and change in depressive symptoms: Mediation by psychological eating styles

Author

Winkens, L. H.H., van Strien, T., Brouwer, I. A., Penninx, B. W.J.H., Visser, M., Winkens, L. H.H., van Strien, T., Brouwer, I. A., Penninx, B. W.J.H., and Visser, M.

Abstract

Earlier cross-sectional research showed that a higher level of mindful eating is associated with less depression. This study investigated associations of attentive mindful eating with change in depressive symptoms, as well as mediation by psychological eating styles, in the Longitudinal Aging Study Amsterdam (n = 946). The mindful eating domains Focused Eating, Eating in response to Hunger and Satiety Cues, Eating with Awareness and Eating without Distraction were measured by the Mindful Eating Behavior Scale. Three-year change in depressive symptoms was measured with the Center for Epidemiologic Studies Depression Scale. Emotional, external and restrained eating were measured by the 20-item version of the Dutch Eating Behaviour Questionnaire. Higher baseline scores on Focused Eating, Eating with Awareness and Eating without Distraction were associated with a 3-year decrease in depressive symptoms. Eating in response to Hunger and Satiety Cues was not associated with a change in depressive symptoms. Multiple mediation models showed mediation by external eating for the domains Eating with Awareness, Eating without Distraction, and Eating in response to Hunger and Satiety Cues, but no mediation by emotional and restrained eating. No mediation by the eating styles was found for Focused Eating. In this study, higher scores on three mindful eating domains were associated with a decrease in depressive symptoms. Mediation analyses suggest that three domains are associated with depression through external eating.

Published
2019
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42. Reliability of cross-sectional and longitudinal brain volume measurements in MS patients using FreeSurfer: a multi-vendor MRI study at 3 Tesla

Author

Amiri, H., Renckens, S., Brouwer, I., Bosschaert, S., van Tuijl, R., Hagens, M., Killestein, J., Barkhof, F., Vrenken, H., Radiology and nuclear medicine, Public and occupational health, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, AII - Inflammatory diseases, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neurodegeneration, and CCA - Cancer biology and immunology

Published
2018

43. High reproducibility and robustness to lesions, but large software and scanner effects for mean upper cervical cord area (MUCCA) measurement in MS

Author

Middelkoop, S., Weeda, M. M., Steenwijk, M. D., Daams, M., Amiri, H., Brouwer, I., Killestein, J., Uitdehaag, B. M. J., Dekker, I., Lukas, C., Bellenberg, B., Barkhof, F., Pouwels, P. J. W., Vrenken, H., Radiology and nuclear medicine, Amsterdam Neuroscience - Neuroinfection & -inflammation, Anatomy and neurosciences, Neurology, AII - Inflammatory diseases, CCA - Imaging and biomarkers, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neurodegeneration, and CCA - Cancer biology and immunology

Published
2018

44. A distributed platform for making large scale manual reference datasets for MS lesion segmentation

Author

Damangir, S., de Sitter, A., Brouwer, I., Guttmann, C. R. G., Pareto, Deborah, Rovira, Alex, Barkhof, F., Vrenken, H., Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, and CCA - Cancer biology and immunology

Published
2018

45. Quantification of spinal cord atrophy in MS: which software, which vertebral level, spinal cord or brain MRI? A multi-centric, longitudinal comparison of three different volumetric approaches

Author

Lukas, C., Prados, F., Valsasina, P., Parmar, K., Brouwer, I., Bellenberg, B., Rovira, A., Chard, D., Kappos, L., Rocca, M. A., Massimo Filippi, Ciccarelli, O., Barkhof, F., Vrenken, H., Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neurodegeneration, Amsterdam Neuroscience - Neuroinfection & -inflammation, and CCA - Cancer biology and immunology

Published
2018

46. OP36 Trans fatty acid biomarkers and incident type 2 diabetes: pooled analysis of 10 prospective cohort studies in the fatty acids and outcomes research consortium (FORCE)

Author

Lai, HTM, primary, Imamura, F, additional, Ardisson Korat, AV, additional, Murphy, R, additional, Tintle, NL, additional, Bassett, J, additional, Chen, J, additional, Kroeger, J, additional, Forouhi, NG, additional, Schulze, MB, additional, Harris, WS, additional, Vasan, RS, additional, Hu, FB, additional, Lemaitre, RN, additional, Giles, GG, additional, Djousse, L, additional, Brouwer, I, additional, Wu, JHY, additional, Marklund, M, additional, and Micha, R, additional

Published
2019
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48. Validation of mean upper cervical cord area (MUCCA) measurement techniques in multiple sclerosis (MS): High reproducibility and robustness to lesions, but large software and scanner effects

Author

Weeda, M.M., primary, Middelkoop, S.M., additional, Steenwijk, M.D., additional, Daams, M., additional, Amiri, H., additional, Brouwer, I., additional, Killestein, J., additional, Uitdehaag, B.M.J., additional, Dekker, I., additional, Lukas, C., additional, Bellenberg, B., additional, Barkhof, F., additional, Pouwels, P.J.W., additional, and Vrenken, H., additional

Published
2019
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49. Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low fish intake

Author

Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Hengeveld, L. M., Praagman, J., Beulens, J. W.J., Brouwer, I. A., van der Schouw, Y. T., Sluijs, I., Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epidemiologie, Hengeveld, L. M., Praagman, J., Beulens, J. W.J., Brouwer, I. A., van der Schouw, Y. T., and Sluijs, I.

Published
2018

50. Nutrition and Health: Micronutrients and Malnutrition : MOOC

Author

Kersten, S., Melse, A., Brouwer, I., Hooiveld, G., Kersten, S., Melse, A., Brouwer, I., and Hooiveld, G.

Abstract

There is an overload of information about nutrition and health, but what is the truth and what can you do to improve the health of your patients? Learn more about nutrition and how our diet profoundly impacts our current and future health. This course addresses the relationship between nutrition and human health, with a focus on health problems related to malnutrition. In this course, Professor Sander Kersten from Wageningen University & Research will explain about the micronutrient (vitamins, minerals, and trace elements) content of foods. You will learn about their role in the body and their impact on our health. Moreover, this course will discuss how suboptimal nutrition may affect human health, with particular attention to malnutrition and global hunger. You will learn about strategies to improve and combat these problems of malnutrition. Finally, the course will make you familiar with nutritional research and research methodologies. This course is especially useful for health care professionals and people working in the food industry with a non-nutrition background. You will develop a critical mind set by learning to better weigh and interpret information about food, nutrition and health. to improve overall health.

Published
2018

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