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4. List of contributors

Author

Adkin, Amie, primary, Allen, Timothy E.H., additional, Almeida, Felipe Alves de, additional, Anelich, Lucia E., additional, Arnold, Mark, additional, Auger, Sandrine, additional, Avermaete, Tessa, additional, Baker-Austin, Craig, additional, Bayer, Forrest L., additional, Bhilegaonkar, Kiran N., additional, Bi, Xiaoyu, additional, Blom, W. Marty, additional, Boobis, Alan R., additional, Boskovic, Marija, additional, Bouwmeester, Hans, additional, Bowering, Gary, additional, Boziaris, Ioannis S., additional, Breen, Christopher J., additional, Brouwer, Hugo, additional, Brown, Ian, additional, Buchanan, Robert L., additional, Buys, Elna M., additional, Caldwell, Jane M., additional, Canellas, Elena, additional, Carneiro, Deisy Guimarães, additional, Carstensen, Karin, additional, Cervantes-Huamán, Brayan R.H., additional, Clemens, Roger, additional, Cocolin, Luca, additional, Cohen, Samuel M., additional, Coles, David, additional, Cossettini, Alessia, additional, Cruz-Martins, Natália, additional, Csikó, György, additional, Danyluk, Michelle, additional, Darwish, Wageh Sobhy, additional, De Coninck, Barbara, additional, Mireles DeWitt, Christina A., additional, Dlamini, B.C., additional, Doe, John, additional, Douglas Kelly, Simon, additional, Dupouy, Eleonora, additional, Eisenbrand, Gerhard, additional, Elegbeleye, James A., additional, Estévez, Pablo, additional, Franco-Duarte, Ricardo, additional, Freitas, Leonardo Luiz de, additional, French, Nigel, additional, Frewer, Lynn J., additional, Fu, Yuqi, additional, Fukushima, Shoji, additional, Gago-Martinez, Ana, additional, Garcia, Alejandro Dorado, additional, Gendel, Steven M., additional, Gerardi, Anne, additional, Ghosh, Anuradha, additional, Glisic, Milica, additional, Godefroy, Samuel Benrejeb, additional, Gooderham, Nigel J., additional, Govers, Gerard, additional, Grenda, Tomasz, additional, Guengerich, F. Peter, additional, Guillou, Sandrine, additional, Gutsell, Steve, additional, Guyard-Nicodème, Muriel, additional, Haddad, Nabila, additional, Haindongo, Ndaindila N.K., additional, Harman, Christie L., additional, Hartung, Thomas, additional, Hayes, A. Wallace, additional, Head, Graham, additional, Hecht, Stephen S., additional, Hoekstra, Jeljer, additional, Hoffman, Louwrens, additional, Honnay, Olivier, additional, Houben, Geert, additional, Jetten, Jan, additional, Jin, Shan, additional, Job, Karen, additional, Kadam, Snehal, additional, Karanth, Shraddha, additional, Karmaus, Agnes, additional, Karvounis, Manos, additional, Kasuga, Fumiko, additional, Kaushik, Karishma S., additional, Kennedy, Marc C., additional, Keogh, John G., additional, Keulemans, Wannes, additional, Khan, Nida, additional, Knowles, Michael E., additional, Kogiannou, Dimitra, additional, Kolesnyk, Serhii, additional, Kolhe, Rahul P., additional, Konold, Timm, additional, Kotsiri, Zoi, additional, Krug, Matt, additional, Kwiatek, Krzysztof, additional, Kwon, Youngjoo, additional, Latronico, Francesca, additional, Leao, José M., additional, LeJeune, Jeffrey T., additional, Li, Wenjing, additional, Linman, Matthew J., additional, López-García, Rebeca, additional, Luechtefeld, Thomas, additional, Magnuson, Bernadene, additional, Manning, Louise, additional, Manouselis, Nikos, additional, Manzano, Marisa, additional, Marin, Marco, additional, Mariotti, María Salomé, additional, Martinez-Urtaza, Jaime, additional, McMullen, Lynn M., additional, McNamara, Cronan, additional, Medina, Angel, additional, Mehlomakulu, N.N., additional, Mehta, Jyotigna M., additional, Meijerink, Marjolein, additional, Miller, J. David, additional, Clare Mills, E.N., additional, Mitchell, Stephen C., additional, Moretto, Angelo, additional, Mugadza, Desmond T., additional, Mukherjee, Keya, additional, Naab, Francis Z., additional, Naegeli, Hanspeter, additional, Nascimento, Maristela S., additional, Nastasijevic, Ivan, additional, Nauta, Maarten, additional, Neretin, Lev, additional, Nerín, Cristina, additional, Ntuli, Victor, additional, Olson, Elena G., additional, O’Brien, John, additional, Painuli, Sakshi, additional, Panteleli, Efstratia, additional, Papakonstantinou, Mihalis, additional, Parlapani, Foteini F., additional, Patyra, Ewelina, additional, Pedreschi, Franco, additional, Pigat, Sandrine, additional, Popping, Bert, additional, Poulsen, Morten, additional, Pradhan, Abani K., additional, Pressman, Peter, additional, Prodanchuk, Mykola, additional, Przeniosło-Siwczyńska, Monika, additional, Punt, Ans, additional, Ramel, Alfons, additional, Rejeb, Abderahman, additional, Rich, Katherine, additional, Ricke, Steven C., additional, Rietjens, Ivonne M.C.M., additional, Rigos, George, additional, Ripolles-Avila, Carolina, additional, Rizzotto, Francesco, additional, Rodrigues, Célia Fortuna, additional, Rodríguez-Jerez, José Juan, additional, Rose, Martin, additional, Rosol, Thomas J., additional, Saha, Joyjit, additional, Savidge, Tor, additional, Seifu, Eyassu, additional, Semwal, Prabhakar, additional, Sibanda, Thulani, additional, So, Sik Yu, additional, Socolovsky, Susana, additional, Stoitsis, Giannis, additional, Stull, Katelynn, additional, Taniwaki, Marta H., additional, Taylor, Sean V., additional, Thompson, Lesa A., additional, Topalcengiz, Zeynal, additional, Tzotzos, George T., additional, van den Honert, Michaela, additional, Van Oijen, Femke L.N., additional, Vanetti, Maria Cristina Dantas, additional, Vantarakis, Apostolos, additional, Vera, Paula, additional, Vidic, Jasmina, additional, Vizzini, Priya, additional, Waring, Rosemary H., additional, Wu, Qinglong, additional, Zaid-Kaylani, Khaldoon, additional, and Zwart, Tjitske Anna, additional

Published
2023
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7. The role of miRNAs in stroke

Author

Breen, Christopher R.

Subjects
616.8, R Medicine (General)
Abstract

Stroke is currently one of the leading causes of death and disability worldwide. Despite recent advances in the treatment of stroke there is a major unmet clinical need for novel therapeutics for intervention. miRNAs are small coding RNAs which act to post-transcriptionally inhibit expression of genes. Emerging evidence has supported the view that miRNAs play an important role in the development and progression of ischaemic stroke, although understanding remains relatively poor. This research uses several models to investigate the effects of miRNAs in the context of stroke in vivo and in vitro, as well as assessment of patient serum samples in order to identify biomarkers for stroke. miR-29b was found to be significantly upregulated in SHRSP rat brain peri-infarct at 72h following stroke, and downregulated in ischaemic core at 24h and 72h following stroke, whilst miR-29c was significantly downregulated in remainder tissue at 24h following stroke and in infarct at 72h following stroke. The upreglation of miR-29b at 72h corresponded to a significant downregulation of miR-29 target genes MMP2, MMP9 and TGF-β1 in peri-infarct tissue at 72h following stroke. Modulation of miR-29b and miR-29c was achieved in a rat neuronal cell line but suppression of genes of interest was not observed following oxygen glucose deprivation. Several candidate miRNAs were then identified by microRNA Openarray analysis in stroke patient serum samples. Validation of these miRNAs was not demonstrated in the population studied, but assessment of these miRNAs in rat serum and isolated exosomes demonstrated that several of these miRNAs were significantly altered in SHRSP rats following stroke. Finally miR-21 was demonstrated to be significantly upregulated in SHRSP rat peri-infarct following stroke. This was associated with a change in miR-21 localization as determined by in situ hybridization. Modulation of miR-21 via the use of CAG-miR-21 mice demonstrated no difference in infarct size as measured by T2 -weighted MRI scan nor was any difference present in behavioural tests versus wild type. KO of miR-21 resulted in a reduction of survival rate compared with wild type. This thesis demonstrates that miR-29 and miR-21 are modulated following stroke in animal models, and these are potential candidates for therapeutic intervention in the future. Analysis of clinical samples has illustrated difficulties in the identification of serum miRNA profiles and suggests that looking at the exosomal component of serum may provide better information regarding miRNA profiles after stroke.

Published
2015

19. What you should know about iLife: How well do you know iPhoto and iMovie? Here are quick primers on both

Author

Breen, Christopher

Subjects
Image processing -- Computer programs -- Methods, Desktop video -- Computer programs, Video tape editing -- Methods, Desktop video software, Image processing software, Business, Computers and office automation industries, Computers, Apple iMovie (Desktop video software) -- Usage, Apple iPhoto (Image processing software) -- Usage
Abstract

ILLUSTRATION BY I LOVE DUST iPhoto The basics of importing, sharing, and editing images, and using Photo Stream. IMPORTING & SHARING IMAGES When you string a USB cable between your [...]

Published
2014

20. Mac 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
Information storage and retrieval -- Methods, Computer files -- Management, Company business management, Desktop accessory software, Business, Computers and office automation industries, Computers
Abstract

How to Restore Your Old iWork Documents Q: I've heard that once you open and edit a Pages '09 file (or another kind of iWork '09 document) that file becomes [...]

Published
2014

21. Mac 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
Amazon.com Inc. -- Services, Mobile devices -- Prices and rates -- Product introduction, Mail-order industry -- Services, Company pricing policy, Business, Computers and office automation industries, Computers
Abstract

Get the Best Amazon Deal While discussing movies with a friend, I realized that I didn't own copies of Alfred Hitchcock's greatest films. Hoping to remedy that, I dashed to [...]

Published
2013

22. Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival.

Author

Breen, Christopher T., Chao, Janet, Mehra, Saral, and Kohli, Nikita

Subjects
*LYMPHOMA treatment, *HEAD tumors, *PUBLIC health surveillance, *MORTALITY, *RESEARCH methodology, *MULTIVARIATE analysis, *COMPARATIVE studies, *SURVIVAL analysis (Biometry), *DESCRIPTIVE statistics, *RESEARCH funding, *LYMPHOMAS, *SALIVARY glands, *NECK tumors
Abstract

Objectives: To describe disease characteristics and treatment and to analyze survival and mortality for extranodal mantle cell lymphoma (MCL) of the head and neck. Methods: Patients with extranodal MCL—excluding primary sites in the salivary glands, eye, and adnexa—were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 Registries (2000-2015). Overall survival (OS) and cumulative incidence of MCL and non-MCL mortality were calculated. Factors associated with MCL and non-MCL mortality were analyzed with cause-specific hazard models. Results: Five hundred nine patients met criteria for descriptive analysis and 294 patients met criteria for survival analysis, with a median follow-up of 58 months. The most common sites for MCL were the oropharynx (66.0%), nasopharynx (19.1%), and oral cavity (8.4%). The most common treatment received was chemotherapy alone (48.9%), followed by chemoradiation therapy (16.9%), and radiation therapy alone (10.4%). The proportion of cases diagnosed as early-stage disease ranged from 31% of sinonasal MCLs to 83% of laryngeal MCLs. At 5 years, OS was 63% (95% CI: 57%-69%). There was no significant difference in OS (P =.79), cumulative incidence of MCL mortality (P =.76), or cumulative incidence of non-MCL mortality (P =.98) by anatomic site. Comparing early-stage to late-stage disease, there was no significant difference in OS (P =.38), cumulative incidence of MCL mortality (P =.07), or cumulative incidence of non-MCL mortality (P =.14). Multivariate analysis showed increased hazard of MCL mortality for patients that were older or that presented with stage III or stage IV disease. Conclusion: The oropharynx is the most common subsite of head and neck MCLs, followed by the nasopharynx. Primary head and neck MCLs appear to present at an earlier stage than MCLs of other regions. In particular, laryngeal and hypopharyngeal MCLs may present as stage I or II disease. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions

Author

Sheeran, Jillian W., primary, Campbell, Kiersten, additional, Breen, Christopher P., additional, Hummel, Gerald, additional, Huang, Changfeng, additional, Datta, Anamika, additional, Boyer, Serge H., additional, Hecker, Scott J., additional, Bio, Matthew M., additional, Fang, Yuan-Qing, additional, Ford, David D., additional, and Russell, M. Grace, additional

Published
2020
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26. Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients

Author

Andronesi, Ovidiu C., primary, Nicholson, Katharine, additional, Jafari-Khouzani, Kourosh, additional, Bogner, Wolfgang, additional, Wang, Jing, additional, Chan, James, additional, Macklin, Eric A., additional, Levine-Weinberg, Mark, additional, Breen, Christopher, additional, Schwarzschild, Michael A., additional, Cudkowicz, Merit, additional, Rosen, Bruce R., additional, Paganoni, Sabrina, additional, and Ratai, Eva-Maria, additional

Published
2020
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27. Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy

Author

Breen, Christopher M., Sykes, Destiny B., Baehr, Carsten, Fricker, Gert, and Miller, David S.

Subjects
Choroid plexus -- Research, Choroid plexus -- Physiological aspects, Rats -- Physiological aspects, Rats -- Research, Rattus -- Physiological aspects, Rattus -- Research, Physiology -- Research, Biological sciences
Abstract

One function of the vertebrate choroid plexus (CP) is removal of potentially toxic metabolites and xenobiotics from cerebrospinal fluid (CSF) to blood for subsequent excretion in urine and bile. We have used confocal microscopy and quantitative image analysis to follow transport of the large organic anion fluorescein-methotrexate (FL-MTX) from bath (CSF side) to blood vessels in intact rat CP and found concentrative transport from CSF to blood. With 2 [micro]M FL-MTX in the bath, steady-state fluorescence in the subepithelium and vascular spaces exceeded bath levels by 5- to 10-fold, but fluorescence in epithelial cells was below bath levels. FL-MTX accumulation in subepithelium and vascular spaces was reduced by NaCN, Na removal, and by other organic anions, e.g., MTX, probenecid, and estrone sulfate. Increasing medium K 10-fold had no effect. None of these treatments affected cellular accumulation. However, two observations indicated that apical FL-MTX uptake was indeed mediated: first, cellular accumulation was a saturable function of medium substrate concentration; and second, digoxin and MK-571 reduced FL-MTX accumulation in the subepithelial/vascular spaces but also increased cellular accumulation severalfold. In the presence of digoxin and MK-571, cellular accumulation was concentrative, specific, and Na dependent. Thus transepithelial FL-MTX transport involved the following two mediated steps: Na-dependent uptake at the apical membrane and electroneutral efflux at the basolateral membrane, possibly on Oatp2 and Mrp1. image analysis; xenobiotic transport

Published
2004

29. The Mac mini media center: set up Apple's littlest Mac to store and share all of your media

Author

Breen, Christopher

Subjects
Microcomputers -- Usage, Business, Computers and office automation industries, Computers, Apple Mac mini (PowerPC-based system) -- Usage
Abstract

Trot back to the 16th century and corner famed prognosticating monk Nostradamus, and it's quite likely that if you were to pose him the question 'Will those living in the [...]

Published
2013

30. Mac 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
Google Inc. -- Services, Desktop video -- Computer programs, Information services industry -- Services, Questions and answers, Information services -- Services, Video tape editing -- Methods, Desktop video software, Desktop utility, Information services industry, Business, Computers and office automation industries, Computers
Abstract

Create Calendar Events More Efficiently Q: My Mac runs Mountain Lion, and I have to fiddle with events after I create them in Calendar--changing all-day events to events that last [...]

Published
2012

31. Confocal imaging of organic anion transport in intact rat choroid plexus

Author

Breen, Christopher M., Sykes, Destiny B., Fricker, Gert, and Miller, David S.

Subjects
Physiology -- Research, Anions -- Physiological aspects, Biological transport -- Research, Choroid plexus -- Physiological aspects, Fluorescein -- Analysis, Biological sciences
Abstract

We used confocal microscopy and quantitative image analysis to follow the movement of the fluorescent organic anion fluorescein (FL) from bath to cell and cell to blood vessel in intact rat lateral choroid plexus. FL accumulation in epithelial cells and underlying vessels was rapid, concentrative, and reduced by other organic anions. At steady state, cell fluorescence exceeded bath fluorescence by a factor of 3-5, and vessel fluorescence exceeded cell fluorescence by a factor of ~2. In cells, FL distributed between diffuse and punctate compartments. Cell and vessel accumulation of FL decreased when metabolism was inhibited by KCN, when bath [Na.sup.+] was reduced from 130 to 26 mM, and when the [Na.sup.+] gradient was collapsed with ouabain. Cell and vessel accumulation increased by >50% when 1-10 [micro]M glutarate was added to the bath. Finally, transport of FL and carboxyfluorescein (generated intracellularly from carboxyfluorescein diacetate) from cell to blood vessel was greatly diminished when medium [K.sup.+] concentration ([[K.sup.+]]) was increased 10-fold. These results 1) validate a new approach to the study of choroid plexus function, and 2) indicate a two-step mechanism for transepithelial organic anion transport: indirect coupling of uptake to [Na.sup.+] at the apical membrane and electrical potential-driven efflux at the basolateral membrane. transepithelial transport; potential-driven efflux; blood-brain barrier; 2,4-dichlorophenoxyacetic acid; fluorescein

Published
2002

34. Mac 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
Electronic mail systems -- Usage, Image processing -- Computer programs, Mouse devices (Computers) -- Usage, Operating systems -- Usage, Questions and answers, 64-bit operating system, 32-bit operating system, Mouse, Image processing software, E-mail software, Operating system, Business, Computers and office automation industries, Computers
Abstract

Lion, Time Machine, and iPhoto Q: I recently installed Lion and dutifully backed up my hard drive with Time Machine. Then I opened iPhoto and, using the Time Machine interface, [...]

Published
2011

35. Beyond cable: three ways to connect your HDTV to your Mac and the net

Author

Breen, Christopher

Subjects
DIRECTV L.L.C., Cable television broadcasting industry -- Methods, Streaming media -- Methods, Television broadcasting industry -- Methods, Streaming media technology, Business, Computers and office automation industries, Computers, iTunes (Sound/audio software)
Abstract

The ubiquitous television set has grown up over the decades. No longer reliant on an antenna picking up a scant few local stations, modern TVs receive programming by the bucket [...]

Published
2011

36. Loss of appetite in amyotrophic lateral sclerosis is associated with weight loss and decreased calorie consumption independent of dysphagia

Author

Mezoian, Taylor, primary, Belt, Emily, additional, Garry, Jamie, additional, Hubbard, Jane, additional, Breen, Christopher T., additional, Miller, Leah, additional, Levine‐Weinberg, Mark, additional, Nalipinski, Paige, additional, Sullivan, Stacey, additional, Chan, James, additional, and Wills, Anne‐Marie, additional

Published
2019
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38. Mac 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
Wireless networking -- Equipment and supplies, Uninterruptible power supply -- Usage, Questions and answers, Music software, UPS, Business, Computers and office automation industries, Computers, GarageBand (Music software) -- Usage
Abstract

Split GarageBand Project into Multiple Tracks Q: I recently used GarageBand to record our church choir singing many songs. Trouble is, because I recorded all the songs at one time, [...]

Published
2010

39. MAC 911: solutions to your most vexing Mac problems

Author

Breen, Christopher

Subjects
10GB - 14.99GB hard disk drive, Hard disk drive, Cable television/data services, Under 5GB hard disk drive, 15GB - 19.99GB hard disk drive, Company business management, Over 25GB hard disk drive, Online services, 5GB - 9.99GB hard disk drive, 20GB - 25GB hard disk drive, Hard disks -- Management -- Usage, File sharing -- Methods -- Usage, User-programmable keys -- Usage -- Methods, Online services -- Usage, Questions and answers -- Methods -- Usage
Abstract

Viewing Large Movies Online Q: I have a 1.75GB MPEG-4 Quick-Time movie file. If I subscribe to MobileMe and use iDisk to upload the movie, will friends and family be […]

Published
2009

40. Picking your iPod: feeling overwhelmed by Apple's media-player lineup? We'll help you find the perfect match

Author

Breen, Christopher

Subjects
MP3 player/device, Microcomputer industry, Computer industry, iTunes (Sound/audio software), Apple iPod shuffle (MP3 player/device), MP3 players -- Purchasing, Computer industry -- Purchasing
Abstract

* In September, Apple performed the now-yearly ritual of updating its iPod lineup in anticipation of the upcoming holiday season. Why? Apple sold 22.7 million iPods in the 2008 holiday […]

Published
2009

41. HD in your pocket: which high-definition mini camcorder is for you?

Author

Breen, Christopher

Subjects
Kodak Zi6 (Camcorder), Creative Labs Vado HD (Camcorder), Genius G-Shot HD 520 (Camcorder), Camcorders -- Product/service Evaluations
Abstract

Up until a year or so ago, camcorders were fairly bulky things. That has changed. Thanks to the development of camcorders that store their recordings on flash media and operate […]

Published
2009

44. Genetic mapping of shnE.3.2 in Drosophila melanogaster

Author

Bieser, Kayla, Sanford, Jamie, Saville, Ken, Arreola, Katherine, Ayres, Zachary, Basulto, David, Benito, Serena, Breen, Christopher, Brix, Julian, Brown, Nicole, Burton, Krissa, Chadwick, Taree, Chen, Matthew, Chu, Katherine, Corbett, Beverly, Dill, Zerrick, Faughender, Meghan, Hickey, Ashlynn, Julia, Joshua, Kelty, Shannon, Jobs, Briggette, Krason, Bryce, Lam, Brian, McCullough, Colin, McEwen, Bryanna, McKenzie, Julian, McQuinn, Kayla, Moritz, Chloe, Myers, Kristina, Naugle, Elizabeth, Nutter, Ashley, O'Conke, Danielle, O'Grondik, Megan, Patel, Kriya, Rudowski, Sydney, Sberna, Emma, Stall, Gunner, Steiner, Tad, Tanriverdi, Eda, Torres Patarroyo, Natalie, Traster, Virginia, Tsai, Leo, Valenti, Andrew, Villegas, Mariela, Voors, Samantha, Watson, Kierra, Wright, Megan, and Kagey, Jacob

Subjects
New Finding, Phenotype Data
Abstract

An EMS screen was conducted utilizing the Flp/FRT system to identify mutations that lead to phenotypic alterations in the size of the eye, the ratio of mutant to wild type tissue (red over white), or the developmental patterning of the mosaic eye. This screen was completed in the genetic background of blocked apoptosis in the homozygous mutant cells to identify conditional regulators of cell growth and eye development (Kagey et al. 2012). The block in apoptosis in the mosaic mutant tissue was achieved by using the FRT42D Dark82 chromosome, which retains the w+mC (pigmentation), as a starting point for the EMS mutagenesis (Akdemir et al. 2006). One of the mutants identified was mutant E.3.2. The mutant mosaic phenotype, generated from the cross FRT42D Dark82 E.3.2 X Ey>Flp; FRT42D, resulted in a range of phenotypes. This included, gross eye pattern disruption, abnormal shape, and antennal overgrowth (see bottom image) when compared to the FRT42D Dark82 mosaic controls (Figure 1A). The control mosaic phenotype had a characteristic 60:40 red:white ratio as compared to the mutant mosaic phenotype of approximately 30:70 red:white ratio. This indicates a reduction in mutant tissue, but included abnormal cranial, eye, and antennal development (Figure 1A).

Published
2019

45. Gear for your iPod; They call it 'the iPod ecosystem'--that's the expanding universe of speakers, headphones, cases, and other player-related paraphernalia that now surrounds the iPod. Worried about finding the right gear to make your iPod sing? We're on the case

Author

Frakes, Dan and Breen, Christopher

Subjects
Microcomputer industry, Computer industry, Griffin Technology Inc. -- Product introduction, Logitech International S.A. -- Product introduction, Headphones -- Product introduction, Computer peripherals industry -- Product introduction, Computer industry -- Product introduction, Cellular telephone equipment industry -- Product introduction
Abstract

Keep it Down in There Given how early and often kids listen to music these days, damage to young ears is a big concern. Ultimate Ears' LoudEnough headphones offer a […]

Published
2008

46. The Kid-Safe MAC A parent's guide to setting up OS X

Author

Breen, Christopher

Subjects
Operating systems -- Usage -- Evaluation, 64-bit operating system, 32-bit operating system, Operating system, Business, Computers and office automation industries, Computers, Kid-Safe MAC A (Operating system) -- Usage -- Evaluation
Abstract

Like puppies, children can be adorable even as they create chaos-splashing about in mud puddles or shrieking on the playground. But, also like their canine companions, kids at play can [...]

Published
2008

47. Shopping advice: once you've decided which Mac best meets your needs, you're only halfway finished. You'll also need to decide where you'll get it and what you should add to your base purchase to make it the Mac for you

Author

Breen, Christopher

Subjects
PowerPC-based system, Microcomputer industry, Computer industry, Apple Inc. -- Services -- Purchasing, Warranty -- Methods, Computer industry -- Services -- Purchasing, Shopping -- Methods
Abstract

Where to Buy You have many choices to consider when you're shopping for a Mac. Apple Retail Stores Apple has made a massive retail push in recent years--both online and […]

Published
2008

50. Spam Fighters: Seven utilities that can keep the junk out of your inbox

Author

Breen, Christopher

Subjects
Personal Antispam 10.4.2 (Email filtering software), SpamSweep 1.5.3 (Email filtering software), Email CRX 1.6.2 (Email filtering software), SpamX 3.0.2 (Email filtering software), MailWasher Pro 1.1.3 (Email filtering software), Spamfire 2.3 (Email filtering software), SpamSieve 2.6.1 (Email filtering software), Email filtering software
Abstract

Anyone who has launched an e-mail client to discover a glut of offers for dubious nostrums, bogus diplomas, and indelicate physical congress is well aware that spam--the junk mail that […]

Published
2007

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