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10. Clusters of adipose tissue dysfunction in adults with type 2 diabetes identify those with worse lipidomic profile despite similar glycaemic control

Author

Della Pepa, Giuseppe, primary, Carli, Fabrizia, additional, Sabatini, Silvia, additional, Pezzica, Samantha, additional, Russo, Marco, additional, Vitale, Marilena, additional, Masulli, Maria, additional, Riccardi, Gabriele, additional, Rivellese, Angela A., additional, Vaccaro, Olga, additional, Bozzetto, Lutgarda, additional, and Gastaldelli, Amalia, additional

Published
2024
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16. Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals: an ancillary analysis of a randomized controlled trial

Author

Della Pepa, Giuseppe, Vetrani, Claudia, Vitale, Marilena, Bozzetto, Lutgarda, Costabile, Giuseppina, Cipriano, Paola, and Mangione, Anna

Subjects
Polyphenols, Triglycerides, Cardiovascular diseases, Blood lipids, Type 2 diabetes, Low density lipoproteins, Diet, Food/cooking/nutrition, Health
Abstract

Background/Objectives Plasma lipoprotein composition, especially in the postprandial state, could be relevant for cardiovascular risk and could be influenced by eating habits. This study evaluated the effects of a polyphenol-rich diet on postprandial lipoprotein composition in individuals at high cardiometabolic risk. Subjects/Methods Seventy-eight individuals with high waist circumference and at least another component of the metabolic syndrome were randomized to either a high-polyphenol (HighP) or low-polyphenol (LowP) diet. Before and after the 8-week intervention, chylomicrons, VLDL1, VLDL2, IDL, LDL, HDL particles, and their lipid concentrations were determined over a 6-h high-fat test meal with high or low-polyphenol content, according to the diet assigned. Results VLDL1 postprandial areas under the curve (AUCs) were lower for cholesterol (Chol) (1.48 [plus or minus] 0.98 vs. 1.91 [plus or minus] 1.13 mmol/L × 6 h, M [plus or minus] SD, p = 0.014) and triglycerides (Tg) (4.70 [plus or minus] 2.70 vs. 6.02 [plus or minus] 3.07 mmol/L × 6 h, p = 0.005) after the HighP than after the LowP diet, with no changes in Chol/Tg ratio. IDL Chol AUCs were higher after the HighP than after the LowP diet (1.29 [plus or minus] 0.77 vs. 1.01 [plus or minus] 0.51 mmol/L × 6 h, p = 0.037). LDL Tg AUCs were higher after the HighP than after the LowP diet (1.15 [plus or minus] 0.33 vs. 1.02 [plus or minus] 0.35 mmol/L × 6 h, p < 0.001), with a lower Chol/Tg ratio (14.6 [plus or minus] 4.0 vs. 16.0 [plus or minus] 3.8, p = 0.007). HDL Tg AUCs were lower after the HighP than after the LowP diet (1.20 [plus or minus] 0.41 vs. 1.34 [plus or minus] 0.37 mmol/L × 6 h, p = 0.013). Conclusions A high-polyphenol diet reduces the postprandial lipid content of large VLDL and increases IDL cholesterol; it modifies the composition of LDL particles--which become richer in triglycerides, and of HDL--which become instead triglyceride poor. The overall changes in atherogenicity by these effects warrant further investigation on clinical cardiovascular outcomes., Author(s): Giuseppe Della Pepa [sup.1], Claudia Vetrani [sup.1], Marilena Vitale [sup.1], Lutgarda Bozzetto [sup.1], Giuseppina Costabile [sup.1], Paola Cipriano [sup.1], Anna Mangione [sup.1], Lidia Patti [sup.1], Gabriele Riccardi [sup.1], Angela [...]

Published
2020
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21. Clinical outcomes of a digitally supported approach for self-management of type 2 diabetes mellitus

Author

De Luca, Vincenzo, primary, Bozzetto, Lutgarda, additional, Giglio, Clemente, additional, Tramontano, Giovanni, additional, De Simone, Giuseppina, additional, Luciano, Antonio, additional, Lucibelli, Luigi, additional, Maffettone, Ada, additional, Riccio, Michele, additional, Romano, Geremia, additional, Rossi, Ernesto, additional, Chiatti, Carlos Juan, additional, Berler, Alexander, additional, Iaccarino, Guido, additional, Illario, Maddalena, additional, and Annuzzi, Giovanni, additional

Published
2023
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22. Insulin pump therapy in type 1 diabetes is associated with lower indices of Non-Alcoholic Fatty Liver in non-obese women but not men

Author

Pepa, Giuseppe Della, primary, Lupoli, Roberta, additional, Masulli, Maria, additional, Boccia, Rosalia, additional, De Angelis, Raffaele, additional, Gianfrancesco, Salvatore, additional, Rainone, Carmen, additional, Rivellese, Angela Albarosa, additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2023
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25. Triticum vulgare Extract and Polyhexanide (Fitostimoline® Hydrogel/Fitostimoline® Plus Gauze) versus Saline Gauze Dressing in Patients with Diabetic Foot Ulcers: Results of a Randomized Controlled Trial

Author

Della Pepa, Giuseppe, primary, Lombardi, Gianluca, additional, Gianfrancesco, Salvatore, additional, Piccolo, Roberto, additional, Chirico, Giovanni, additional, Pellegrino, Micaela, additional, Santella, Luigi, additional, Tecce, Nicola, additional, Volpicelli, Anastasia, additional, Sollo, Elena, additional, Bozzetto, Lutgarda, additional, Masulli, Maria, additional, Riccardi, Gabriele, additional, Rivellese, Angela Albarosa, additional, and Saldalamacchia, Gennaro, additional

Published
2023
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27. Exploring Nutritional Influence on Blood Glucose Forecasting for Type 1 Diabetes Using Explainable AI

Author

Annuzzi, Giovanni, Apicella, Andrea, Arpaia, Pasquale, Bozzetto, Lutgarda, Criscuolo, Sabatina, De Benedetto, Egidio, Pesola, Marisa, and Prevete, Roberto

Abstract

Type 1 diabetes mellitus (T1DM) is characterized by insulin deficiency and blood sugar control issues. The state-of-the-art solution is the artificial pancreas (AP), which integrates basal insulin delivery and glucose monitoring. However, APs are unable to manage postprandial glucose response (PGR) due to limited knowledge of its determinants, requiring additional information for accurate bolus delivery, such as estimated carbohydrate intake. This study aims to quantify the influence of various meal-related factors on predicting postprandial blood glucose levels (BGLs) at different time intervals (15 min, 60 min, and 120 min) after meals by using deep neural network (DNN) models. The prediction models incorporate preprandial blood glucose values, insulin dosage, and various meal-related nutritional factors such as intake of energy, carbohydrates, proteins, lipids, fatty acids, fibers, glycemic index, and glycemic load as input variables. The impact of input features was assessed by exploiting eXplainable Artificial Intelligence (XAI) methodologies, specifically SHapley Additive exPlanations (SHAP), which provide insights into each feature's contribution to the model predictions. By leveraging XAI methodologies, this study aims to enhance the interpretability and transparency of BGL prediction models and validate clinical literature hypotheses. The findings can aid in the development of decision-support tools for individuals with T1DM, facilitating PGR management and reducing the risks of adverse events. The improved understanding of PGR determinants may lead to advancements in AP technology and improve the overall quality of life for T1DM patients.

Published
2024
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29. Association between Diet Quality and Index of Non-Alcoholic Steatohepatitis in a Large Population of People with Type 2 Diabetes: Data from the TOSCA.IT Study

Author

Vitale, Marilena, primary, Della Pepa, Giuseppe, additional, Costabile, Giuseppina, additional, Bozzetto, Lutgarda, additional, Cipriano, Paola, additional, Signorini, Stefano, additional, Leoni, Valerio, additional, Riccardi, Gabriele, additional, Vaccaro, Olga, additional, and Masulli, Maria, additional

Published
2022
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32. Management of Prolonged Aerobic Exercise in People With Type 1 Diabetes on Automated Insulin Delivery Systems: A Randomized Controlled Study.

Author

Corrado, Alessandra, Scidà, Giuseppe, Abuqwider, Jumana, Rainone, Carmen, Lupoli, Roberta, Masulli, Maria, Bozzetto, Lutgarda, and Annuzzi, Giovanni

Subjects
CONTINUOUS glucose monitoring, TYPE 1 diabetes, MEDICAL personnel, GLYCEMIC control, ARTIFICIAL pancreases
Abstract

A study published in Diabetes Care examined the management of prolonged aerobic exercise in individuals with type 1 diabetes who use automated insulin delivery (AID) systems. The study compared three different strategies: setting a higher temporary glucose target, consuming 15g of complex carbohydrates every 30 minutes during exercise, or combining the two interventions. The results showed that setting a higher glucose target alone was the most effective strategy for maintaining glycemia during exercise, with lower doses of automatically delivered insulin. The study suggests that low-to-moderately active individuals with type 1 diabetes can safely engage in prolonged aerobic activities with tight glycemic control using AID. [Extracted from the article]

Published
2024
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34. Comparison of Insulin Dose Adjustments Made by Artificial Intelligence-Based Decision Support Systems and by Physicians in People with Type 1 Diabetes Using Multiple Daily Injections Therapy

Author

Nimri, Revital, primary, Tirosh, Amir, additional, Muller, Ido, additional, Shtrit, Yael, additional, Kraljevic, Ivana, additional, Alonso, Montserrat Martín, additional, Milicic, Tanja, additional, Saboo, Banshi, additional, Deeb, Asma, additional, Christoforidis, Athanasios, additional, den Brinker, Marieke, additional, Bozzetto, Lutgarda, additional, Bolla, Andrea Mario, additional, Krcma, Michal, additional, Rabini, Rosa Anna, additional, Tabba, Shadi, additional, Gerasimidi-Vazeou, Andriani, additional, Maltoni, Giulio, additional, Giani, Elisa, additional, Dotan, Idit, additional, Liberty, Idit F., additional, Toledano, Yoel, additional, Kordonouri, Olga, additional, Bratina, Natasa, additional, Dovc, Klemen, additional, Biester, Torben, additional, Atlas, Eran, additional, and Phillip, Moshe, additional

Published
2022
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35. An Isoenergetic Multifactorial Diet Reduces Pancreatic Fat and Increases Postprandial Insulin Response in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Author

Della Pepa, Giuseppe, primary, Brancato, Valentina, additional, Costabile, Giuseppina, additional, Salamone, Dominic, additional, Corrado, Alessandra, additional, Vitale, Marilena, additional, Cavaliere, Carlo, additional, Mancini, Marcello, additional, Salvatore, Marco, additional, Luongo, Delia, additional, Riccardi, Gabriele, additional, Rivellese, Angela A., additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2022
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36. An isoenergetic multifactorial diet reduces pancreatic fat and increases postprandial insulin response in patients with type 2 diabetes: a randomized controlled trial

Author

Pepa, Giuseppe Della, primary, Brancato, Valentina, primary, Costabile, Giuseppina, primary, Salamone, Dominic, primary, Corrado, Alessandra, primary, Vitale, Marilena, primary, Cavaliere, Carlo, primary, Mancini, Marcello, primary, Salvatore, Marco, primary, Luongo, Delia, primary, Riccardi, Gabriele, primary, Rivellese, Angela A., primary, Annuzzi, Giovanni, primary, and Bozzetto, Lutgarda, primary

Published
2022
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38. Triticum vulgare Extract and Polyhexanide (Fitostimoline ® Hydrogel/Fitostimoline ® Plus Gauze) versus Saline Gauze Dressing in Patients with Diabetic Foot Ulcers: Results of a Randomized Controlled Trial.

Author

Della Pepa, Giuseppe, Lombardi, Gianluca, Gianfrancesco, Salvatore, Piccolo, Roberto, Chirico, Giovanni, Pellegrino, Micaela, Santella, Luigi, Tecce, Nicola, Volpicelli, Anastasia, Sollo, Elena, Bozzetto, Lutgarda, Masulli, Maria, Riccardi, Gabriele, Rivellese, Angela Albarosa, and Saldalamacchia, Gennaro

Subjects
DIABETIC foot, WHEAT, COCAINE-induced disorders, RANDOMIZED controlled trials, PEOPLE with diabetes, HYDROGELS
Abstract

Background: The use of dressings is an essential component of the standard of care for diabetic foot ulcers (DFUs); however, despite the wide variety of dressings available, there is a lack of evidence from head-to-head randomized controlled trials. We evaluated the efficacy and safety of Triticum vulgare extract and polyhexanide (Fitostimoline® hydrogel/Fitostimoline® Plus gauze) versus saline gauze dressings in patients with DFUs. Methods: This study involved a monocentric, two-arm, open-label, controlled trial in patients with DFUs (Grades I or II, Stage A or C, based on the Texas classification) randomized to 12 weeks of dressing with Fitostimoline® hydrogel/Fitostimoline® Plus gauze or saline gauze. The number of patients with complete healing, the reduction in DFU size, and the presence of local signs and symptoms of the wound and perilesional skin were evaluated every two weeks and at the end of treatment. Results: A total of 40 adult patients were recruited (20 patients in each treatment group). The proportion of patients with complete healing was similar between the two groups (61% vs. 74%, p = 0.495, Fitostimoline® hydrogel/Fitostimoline® Plus gauze vs. saline gauze, respectively), without significant differences, as well as the reduction in DFU size. A significant improvement in local signs and symptoms of the wound and signs of perilesional skin in the Fitostimoline® hydrogel/Fitostimoline® Plus gauze compared with the saline gauze group was observed. Conclusions: In a clinical setting, the use of Fitostimoline® hydrogel/Fitostimoline® Plus gauze dressing in patients with DFUs significantly improves signs and symptoms of the wound and signs of perilesional skin compared with saline gauze dressing with a similar efficacy in terms of wound healing. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial

Author

Costabile, Giuseppina, primary, Della Pepa, Giuseppe, additional, Salamone, Dominic, additional, Luongo, Delia, additional, Naviglio, Daniele, additional, Brancato, Valentina, additional, Cavaliere, Carlo, additional, Salvatore, Marco, additional, Cipriano, Paola, additional, Vitale, Marilena, additional, Corrado, Alessandra, additional, Rivellese, Angela Albarosa, additional, Annuzzi, Giovanni, additional, and Bozzetto, Lutgarda, additional

Published
2022
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43. Contributors

Author

Alrefai, Waddah A., primary, Amaya-Farfan, Jaime, additional, Annuzzi, Giovanni, additional, Antvorskov, Julie C., additional, Ardévol, Anna, additional, Bach Knudsen, Knud Erik, additional, Berciano, Silvia, additional, Blackett, Piers R., additional, Blay, Mayte, additional, Bozzetto, Lutgarda, additional, Buschard, Karsten, additional, Cai, Lu, additional, Chen, Younan, additional, Chiazza, Fausto, additional, Collares-Buzato, Carla Beatriz, additional, Collino, Massimo, additional, Costabile, Giuseppina, additional, Cruzat, Vinicius F., additional, Cuéllar, Leticia, additional, Daimiel-Ruiz, Lidia, additional, Dalgaard, Louise T., additional, de la Monte, Suzanne M., additional, Dragano, Nathalia Romanelli Vicente, additional, Dudeja, Pradeep K., additional, Esteve, Eduardo, additional, Fernández-Real, José Manuel, additional, García, Lidia, additional, Garg, Manohar L., additional, Gasa, Rosa, additional, Geiger, Julian, additional, Gill, Ravinder K., additional, Girard, Jean, additional, Gomis, Ramon, additional, González-Abuín, Noemí, additional, Goya, Luis, additional, Griffo, Ettore, additional, Hartvigsen, Merete Lindberg, additional, Hedemann, Mette Skou, additional, Hermansen, Kjeld, additional, Huse, Susan, additional, Jin, Tianru, additional, Josefsen, Knud, additional, Kim, Miran, additional, Kutala, Vijay Kumar, additional, Langhans, Wolfgang, additional, Liu, Gilbert C., additional, Lollo, Pablo C.B., additional, Lopez-Miranda, Jose, additional, López Ríos, Laura, additional, Lyssenko, Valeriya, additional, Malhotra, Pooja, additional, Mansouri, Abdelhak, additional, Marin, Carmen, additional, Marques, Anne y Castro, additional, Martin, Maria Ángeles, additional, Miao, Xiao, additional, Mico, Victor, additional, Milanski, Marciane, additional, Morato, Priscila N., additional, Moura, Carolina S., additional, Naushad, Shaik Mohammad, additional, Newsholme, Philip, additional, Novials, Anna, additional, Ordovas, Jose M., additional, Pinent, Montserrat, additional, Prip-Buus, Carina, additional, Ramaiah, M. Janaki, additional, Ramos, Sonia, additional, Ricart, Wifredo, additional, Sala, David, additional, Salö, Sofia, additional, Sánchez Hernández, Rosa M., additional, Sanghera, Dharambir K., additional, Servitja, Joan-Marc, additional, Sørensen, Anja E., additional, Sun, Jian, additional, Thomas, Jency, additional, Torsoni, Adriana Souza, additional, Torsoni, Marcio Alberto, additional, Uruno, Akira, additional, Wägner, Ana M., additional, Wang, Shudong, additional, Wang, Yonggang, additional, Wiebe, Julia C., additional, Wintergerst, Kupper A., additional, Xifra, Gemma, additional, Yagishita, Yoko, additional, Yamamoto, Masayuki, additional, and Zorzano, Antonio, additional

Published
2016
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45. Evaluation of a Whole-Liver Dixon-Based MRI Approach for Quantification of Liver Fat in Patients with Type 2 Diabetes Treated with Two Isocaloric Different Diets

Author

Brancato, Valentina, primary, Della Pepa, Giuseppe, additional, Bozzetto, Lutgarda, additional, Vitale, Marilena, additional, Annuzzi, Giovanni, additional, Basso, Luca, additional, Cavaliere, Carlo, additional, Salvatore, Marco, additional, Rivellese, Angela Albarosa, additional, and Monti, Serena, additional

Published
2022
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