10 results on '"BOURNE-WATRIN, Morgane"'
Search Results
2. Development of a case fatality prognostic score for HIV-associated histoplasmosis
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Françoise, Ugo, Nacher, Mathieu, Bourne-watrin, Morgane, Epelboin, Loïc, Thorey, Camille, Demar, Magalie, Carod, Jean-François, Djossou, Félix, Couppié, Pierre, and Adenis, Antoine
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- 2023
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3. Histoplasmosis in Non-HIV Infected Patients: Another Neglected Infection in French Guiana.
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Aissaoui, Houari, Bourne-Watrin, Morgane, Lemarie, Benoit, Guillot, Genevieve, Aboikoni, Alolia, Chhorn, Piseth, Gaudard, Dana, Hadj-Amara, Ghazi, Manasse, Ricardo, Ouedraogo, Mahamado, Salloum, Charles, Demar, Magalie, Epelboin, Loïc, Kallel, Hatem, Adenis, Antoine, Nacher, Mathieu, Drak Alsibai, Kinan, and Louvel, Dominique
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HISTOPLASMOSIS , *HOSPITAL patients , *DEATH rate , *SEX ratio , *IMMUNOSUPPRESSIVE agents - Abstract
(1) Background: Only a few studies on histoplasmosis in immunocompetent patients have been reported in French Guiana. Therefore, we conducted a detailed clinical description of hospitalized patients suffering with histoplasmosis among non-HIV patients. (2) Methods: This is a single-center, retrospective study conducted at Cayenne Hospital Center between 2008 and 2022. (3) Results: Our cohort was composed of 31 (91%) adults (>18 years of age) and 3 (9%) children, with a sex ratio, M:F, of 1:2. The median age was higher among the women than among the men (70 versus 54 years). The collection of respiratory samples constituted the majority of the performed examinations (38%). Fever (>37 °C) was found in 56% of patients. Surprisingly, the histoplasmosis was disseminated in 82% of patients with an overall case fatality rate of 14.7%. However, immunosuppressive conditions were found in 52% (16/31) of the adult patients, including lymphoid hemopathies, diabetes and immunosuppressive drugs. Conclusions: This disease, though rare and usually considered a mostly benign disease in non-HIV patients, presented a relatively high mortality rate in our cohort. Thus, histoplasmosis should be suspected, screened and investigated as a first line of defense in highly endemic areas, even in immunocompetent and non-HIV patients, especially those with fever or chronic respiratory symptoms. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Infectious Mediastinitis: A Retrospective Cohort Study.
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Lemmet, Thomas, Mazzucotelli, Jean-Philippe, Collange, Olivier, Fath, Léa, Mutter, Didier, Brigand, Cécile, Falcoz, Pierre-Emmanuel, Danion, François, Lefebvre, Nicolas, Bourne-Watrin, Morgane, Gerber, Victor, Hoellinger, Baptiste, Fabacher, Thibaut, Hansmann, Yves, and Ruch, Yvon
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MEDIASTINITIS ,ESOPHAGEAL perforation ,COHORT analysis ,ORAL microbiology ,RETROSPECTIVE studies ,UNIVERSITY hospitals - Abstract
Background This study aimed to characterize the demographics, microbiology, management and treatment outcomes of mediastinitis according to the origin of the infection. Methods This retrospective observational study enrolled patients who had mediastinitis diagnosed according to the criteria defined by the Centers for Disease Control and Prevention and were treated in Strasbourg University Hospital, France, between 1 January 2010 and 31 December 2020. Results We investigated 151 cases, including 63 cases of poststernotomy mediastinitis (PSM), 60 cases of mediastinitis due to esophageal perforation (MEP) and 17 cases of descending necrotizing mediastinitis (DNM). The mean patient age (standard deviation) was 63 (14.5) years, and 109 of 151 patients were male. Microbiological documentation varied according to the origin of the infection. When documented, PSM cases were mostly monomicrobial (36 of 53 cases [67.9%]) and involved staphylococci (36 of 53 [67.9%]), whereas MEP and DNM cases were mostly plurimicrobial (38 of 48 [79.2%] and 8 of 12 [66.7%], respectively) and involved digestive or oral flora microorganisms, respectively. The median duration of anti-infective treatment was 41 days (interquartile range, 21–56 days), and 122 of 151 patients (80.8%) benefited from early surgical management. The overall 1-year survival rate was estimated to be 64.8% (95% confidence interval, 56.6%–74.3%), but varied from 80.1% for DNM to 61.5% for MEP. Conclusions Mediastinitis represents a rare yet deadly infection. The present cohort study exhibited the different patterns observed according to the origin of the infection. Greater insight and knowledge on these differences may help guide the management of these complex infections, especially with respect to empirical anti-infective treatments. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Panorama des pathologies infectieuses et non infectieuses de Guyane en 2022
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EPELBOIN, Loïc, ABBOUD, Philippe, ABDELMOUMEN, Karim, ABOUT, Frédégonde, ADENIS, Antoine, BLAISE, Théo, BLAIZOT, Romain, BONIFAY, Timothée, BOURNE-WATRIN, Morgane, BOUTROU, Mathilde, CARLES, Gabriel, CARLIER, Pierre-Yves, CAROD, Jean-François, CARVALHO, Luisiane, COUPPIÈ, Pierre, DE TOFFOL, Bertrand, DELON, François, DEMAR, Magalie, DESTOOP, Justin, DOUINE, Maylis, DROZ, Jean-Pierre, ELENGA, Narcisse, ENFISSI, Antoine, FRANCK, Yves-Kénol, FREMERY, Alexis, GAILLET, Mélanie, KALLEL, Hatem, KPANGON, Arsène Amadouhé, LAVERGNE, Anne, LE TURNIER, Paul, MAISONOBE, Lucas, MICHAUD, Céline, MUTRICY, Rémi, NACHER, Mathieu, NALDJINAN-KODBAYE, Richard, OBERLIS, Margot, ODONNE, Guillaume, OSEI, Lindsay, PUJO, Jean, RABIER, Sébastien, ROMAN-LAVERDURE, Brigitte, ROUSSEAU, Cyril, ROUSSET, Dominique, SABBAH, Nadia, SAINTE-ROSE, Vincent, SCHAUB, Roxane, SYLLA, Karamba, TAREAU, Marc-Alexandre, TERTRE, Victor, THOREY, Camille, VIALETTE, Véronique, WALTER, Gaëlle, Magaly, Magaly, DJOSSOU, Félix, and VIGNIER, Nicolas
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Overview of infectious and non-infectious diseases in French Guiana in 2022 Source of many myths, French Guiana represents an exceptional territory due to the richness of its biodiversity and the variety of its communities. The only European territory in Amazonia, surrounded by the Brazilian giant and the little-known Suriname, Ariane 6 rockets are launched from Kourou while 50% of the population lives below the poverty line. This paradoxical situation is a source of health problems specific to this territory, whether they be infectious diseases with unknown germs, intoxications or chronic pathologies. Some infectious diseases such as Q fever, toxoplasmosis, cryptococcosis or HIV infection are in common with temperate countries, but present specificities leading to sometimes different management and medical reasoning. In addition to these pathologies, many tropical diseases are present in an endemic and / or epidemic mode such as malaria, leishmaniasis, Chagas disease, histoplasmosis or dengue. Besides, Amazonian dermatology is extremely varied, ranging from rare but serious pathologies (Buruli ulcer, leprosy) to others which are frequent and benign such as agouti lice (mites of the family Trombiculidae) or papillonitis. Envenomations by wild fauna are not rare, and deserve an appropriate management of the incriminated taxon. Obstetrical, cardiovascular and metabolic cosmopolitan pathologies sometimes take on a particular dimension in French Guiana that must be taken into account in the management of patients. Finally, different types of intoxication are to be known by practitioners, especially due to heavy metals. European-level resources offer diagnostic and therapeutic possibilities that do not exist in the surrounding countries and regions, thus allowing the management of diseases that are not well known elsewhere. Thanks to these same European-level resources, research in Guyana occupies a key place within the Amazon region, despite a smaller population than in the surrounding countries. Thus, certain pathologies such as histoplasmosis of the immunocompromised patient, Amazonian toxoplasmosis or Q fever are hardly described in neighboring countries, probably due to under-diagnosis linked to more limited resources. French Guiana plays a leading role in the study of these diseases. The objective of this overview is to guide health care providers coming to or practicing in French Guiana in their daily practice, but also practitioners taking care of people returning from French Guiana. Panorama des pathologies infectieuses et non infectieuses de Guyane en 2022 Source de nombreux mythes, la Guyane représente un territoire exceptionnel par la richesse de sa biodiversité et par la variété des communautés qui la composent. Seul territoire européen en Amazonie, entouré du géant brésilien et du méconnu Suriname, on y lance des fusées Ariane 6 depuis Kourou tandis que 50 % de la population vit en dessous du seuil de pauvreté. Cette situation paradoxale est source de problématiques de santé spécifiques à ce territoire, qu’il s’agisse de maladies infectieuses à germes méconnus, d’intoxications, ou de pathologies chroniques. Certaines maladies infectieuses telles que la fièvre Q, la toxoplasmose, la cryptococcose ou l’infection à VIH sont communes aux pays tempérés, mais présentent en Guyane des spécificités entraînant une prise en charge et un raisonnement médical parfois différents. Parallèlement à ces pathologies, de nombreuses maladies tropicales sont par ailleurs présentes sur un mode endémique et / ou épidémique telles que le paludisme, la leishmaniose, la maladie de Chagas, l’histoplasmose ou la dengue. De plus, la dermatologie amazonienne est extrêmement variée, allant de pathologies rares, mais graves (ulcère de Buruli, lèpre), à d’autres fréquentes et bénignes telles que les poux d’agouti (acariens de la famille des Trombiculidae) ou la papillonite. Les envenimations par la faune sauvage ne sont pas rares, et méritent une prise en charge appropriée au taxon incriminé. Les pathologies obstétricale, cardiovasculaire et métabolique cosmopolites prennent parfois en Guyane une dimension particulière à prendre en compte dans la prise en charge des patients. Enfin, différents types d’intoxication sont à connaître par les praticiens, notamment aux métaux lourds. Les ressources de niveau européen offrent des possibilités diagnostiques et thérapeutiques inexistantes dans les pays et régions des environs, permettant ainsi la prise en charge de maladies peu connues ailleurs. Du fait de ces mêmes ressources de niveau européen, la recherche en Guyane occupe une place clé au sein de la région amazonienne, malgré une population moins nombreuse que dans les pays alentour. Ainsi, certaines pathologies telles que l’histoplasmose du patient immunodéprimé, la toxoplasmose amazonienne ou la fièvre Q ne sont pratiquement pas décrites dans les pays voisins, probablement du fait d’un sous-diagnostic lié à des ressources plus limitées. La Guyane joue ainsi un rôle moteur dans l’étude de ces pathologies. L’objectif de ce panorama est d’orienter les soignants venant ou exerçant en Guyane dans leur pratique quotidienne, mais également les praticiens prenant en charge des personnes au retour de Guyane., MTSI, Vol. 3 No 1 (2023): MTSI-Revue
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- 2023
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6. 5e journée des travaux scientifiques des soignants de Guyane. Nos soignants ont du talent ! 19 & 20 mai 2022, Cayenne, Guyane
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LUCARELLI, Aude, HUREAU-MUTRICY, Louise, SOLIGNAT, Blandine, BOURNE-WATRIN, Morgane, BLAISE, Théo, OSEI, Lindsay, COUSIN, Pauline, BOUTROU, Mathilde, DESTOOP, Justin, Alexis, Alexis, MUTRICY, Rémi, BONIFAY, Timothée, and EPELBOIN, Loïc
- Abstract
Ces 19 et 20 mai 2022 se sont tenues à Cayenne, en Guyane, les 5e journées des travaux scientifiques des soignants de Guyane « Nos soignants ont du talent ». Ces dernières ont remplacé depuis 2021 les Journées des travaux scientifiques des jeunes médecins de Guyane « Nos internes ont du talent », en s’ouvrant largement à d’autres corps de métier de la santé. Ainsi, lors de cette nouvelle session, 10 infirmières, 4 sages-femmes, 1 pharmacienne, 1 technicienne de laboratoire et 22 médecins ont contribué aux communications orales et affichées de ces journées. Les sujets abordés ont touché des domaines extrêmement variés, avec des travaux concernant les zoonoses (rage, fièvre Q), les interactions entre l’homme avec la faune sauvage (envenimation par la faune sauvage, en particulier ophidienne), la santé publique en zone isolée (Covid, VIH, paludisme), l’épidémiologie tropicale (hémopathies liées à l’HTLV, histoplasmose pulmonaire, toxoplasmose, tuberculose, fièvre jaune), la dermatologie tropicale (prurigo du VIH, dermo-hypodermites, dermatologie en zone isolée, leishmaniose cutanée), la périnatalité (exposition au plomb chez les femmes enceintes, causes de mort fœtale in utero, dépistage du cancer du col de l’utérus), la santé notamment sexuelle, mais aussi globale et addictive de différentes populations (orpailleurs clandestins, populations incarcérées, femmes migrantes, agriculteurs), les pathologies cardiovasculaires et les hémoglobinopathies (diabète, AVC, drépanocytose), la prise en charge des violences (épidémiologie des plaies par arme à feu, violences sexuelles et conjugales), la mise en place de projets en santé communautaire dans les quartiers défavorisés (Covid, eau-hygiène-assainissement), les soins et patients (interculturalité, barrière de la langue, EVASAN). Ces journées se sont tenues pour la deuxième fois en format mixte présentiel et/ou distanciel, avec environ 200 participants chaque jour qui ont assisté aux présentations et contribué aux débats. Enfin, le retour sur les années précédentes a montré que les travaux présentés lors de ces journées de Guyane sont loin d’être limités en termes d’intérêt scientifique à la sphère locale « guyano-guyanaise ». En effet, un pourcentage non négligeable des présentations réalisées ces dernières années a fait l’objet de publications dans des journaux internationaux principalement anglophones – 16/19 (84 %) en 2017, 9/28 (32 %) en 2018, 8/25 (32 %) en 2019 et 10/25 (40 %) en 2021. Tous les organisateurs de ces journées originales espèrent que l’implication et l’engouement des soignants pour la recherche scientifique se poursuivent, et connaissent une importance grandissante lors des sessions à venir., MTSI, Vol. 2 No 2 (2022): MTSI-Revue
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- 2022
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7. Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana
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Drak Alsibai, Kinan, primary, Aissaoui, Houari, additional, Adenis, Antoine, additional, Bourne-Watrin, Morgane, additional, Djossou, Felix, additional, Epelboin, Loïc, additional, Blanchet, Denis, additional, Demar, Magalie, additional, Couppié, Pierre, additional, and Nacher, Mathieu, additional
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- 2021
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8. The Broad Clinical Spectrum of Disseminated Histoplasmosis in HIV-Infected Patients: A 30 Years’ Experience in French Guiana
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Couppié, Pierre, primary, Herceg, Katarina, additional, Bourne-Watrin, Morgane, additional, Thomas, Vincent, additional, Blanchet, Denis, additional, Alsibai, Kinan Drak, additional, Louvel, Dominique, additional, Djossou, Felix, additional, Demar, Magalie, additional, Blaizot, Romain, additional, and Adenis, Antoine, additional
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- 2019
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9. Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana.
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Alsibai, Kinan Drak, Aissaoui, Houari, Adenis, Antoine, Bourne-Watrin, Morgane, Djossou, Felix, Epelboin, Loïc, Blanchet, Denis, Demar, Magalie, Couppié, Pierre, and Nacher, Mathieu
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HISTOPLASMOSIS diagnosis ,BRONCHOALVEOLAR lavage ,HISTOPLASMA capsulatum ,IMMUNOCOMPETENCE ,CYTOLOGY - Abstract
Disseminated histoplasmosis is a major cause of mortality in HIV-infected patients. Rapid and efficient diagnosis of Histoplasma capsulatum is crucial. Cytopathology is available in most hospitals and represents a rapid diagnostic alternative. In this study, we reviewed 12 years of experience to describe the cytology of histoplasmosis diagnosed by bronchoalveolar lavage (BAL) in relation to patient characteristics. BAL-diagnosed pulmonary histoplasmosis concerned 17 patients (14 HIV+). BAL cellularity ranged from 76,000 to 125,000 cells/mL in HIV patients, and 117,000 to 160,000 cells/mL in non-HIV patients. Macrophages predominated in all HIV patients (from 60% to 88%), lymphocytic infiltrates ranged from 5% to 15%, and neutrophils were very heterogeneous (from 2% to 32%). The number of H. capsulatum at hot spots seemed greater in HIV-infected than in immunocompetent patients (9 to 375 vs. 4 to 10) and were inversely proportional to the CD4 counts. Yeasts were both intracellular and extracellular in 85.7% of the HIV patients. This is the most comprehensive series detailing the cytological aspects of BAL in the diagnosis of H. capsulatum, focusing on the number of yeasts and their clustering pattern. The cytological examination of the Gomori-Grocott-stained BAL allows a reliable diagnosis of histoplasmosis. [ABSTRACT FROM AUTHOR]
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- 2021
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10. [Overview of infectious and non-infectious diseases in French Guiana in 2022].
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Epelboin L, Abboud P, Abdelmoumen K, About F, Adenis A, Blaise T, Blaizot R, Bonifay T, Bourne-Watrin M, Boutrou M, Carles G, Carlier PY, Carod JF, Carvalho L, Couppié P, De Toffol B, Delon F, Demar M, Destoop J, Douine M, Droz JP, Elenga N, Enfissi A, Franck YK, Fremery A, Gaillet M, Kallel H, Kpangon AA, Lavergne A, Le Turnier P, Maisonobe L, Michaud C, Mutricy R, Nacher M, Naldjinan-Kodbaye R, Oberlis M, Odonne G, Osei L, Pujo J, Rabier S, Roman-Laverdure B, Rousseau C, Rousset D, Sabbah N, Sainte-Rose V, Schaub R, Sylla K, Tareau MA, Tertre V, Thorey C, Vialette V, Walter G, Zappa M, Djossou F, and Vignier N
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- Animals, Humans, French Guiana epidemiology, Communicable Diseases, Cuniculidae, Histoplasmosis, HIV Infections, Noncommunicable Diseases, Q Fever, Toxoplasmosis diagnosis
- Abstract
Source of many myths, French Guiana represents an exceptional territory due to the richness of its biodiversity and the variety of its communities. The only European territory in Amazonia, surrounded by the Brazilian giant and the little-known Suriname, Ariane 6 rockets are launched from Kourou while 50% of the population lives below the poverty line. This paradoxical situation is a source of health problems specific to this territory, whether they be infectious diseases with unknown germs, intoxications or chronic pathologies.Some infectious diseases such as Q fever, toxoplasmosis, cryptococcosis or HIV infection are in common with temperate countries, but present specificities leading to sometimes different management and medical reasoning. In addition to these pathologies, many tropical diseases are present in an endemic and / or epidemic mode such as malaria, leishmaniasis, Chagas disease, histoplasmosis or dengue. Besides, Amazonian dermatology is extremely varied, ranging from rare but serious pathologies (Buruli ulcer, leprosy) to others which are frequent and benign such as agouti lice (mites of the family Trombiculidae) or papillonitis. Envenomations by wild fauna are not rare, and deserve an appropriate management of the incriminated taxon. Obstetrical, cardiovascular and metabolic cosmopolitan pathologies sometimes take on a particular dimension in French Guiana that must be taken into account in the management of patients. Finally, different types of intoxication are to be known by practitioners, especially due to heavy metals.European-level resources offer diagnostic and therapeutic possibilities that do not exist in the surrounding countries and regions, thus allowing the management of diseases that are not well known elsewhere.Thanks to these same European-level resources, research in Guyana occupies a key place within the Amazon region, despite a smaller population than in the surrounding countries. Thus, certain pathologies such as histoplasmosis of the immunocompromised patient, Amazonian toxoplasmosis or Q fever are hardly described in neighboring countries, probably due to under-diagnosis linked to more limited resources. French Guiana plays a leading role in the study of these diseases.The objective of this overview is to guide health care providers coming to or practicing in French Guiana in their daily practice, but also practitioners taking care of people returning from French Guiana., (Copyright © 2023 SFMTSI.)
- Published
- 2023
- Full Text
- View/download PDF
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