1. Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes
- Author
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Helene M. Paarup, Linda Jenny Handgaard, Bjarne Kuno Møller, Erik Sørensen, Jens Kjærgaard Boldsen, Thomas Hansen, Ole Birger Pedersen, Christian Erikstrup, Karina Banasik, Kristoffer Sølvsten Burgdorf, Mikkel Steen Petersen, Susan Mikkelsen, Torben Sigsgaard, Henrik Ullum, Kathrine Agergård Kaspersen, Henrik Hjalgrim, Gitte Juel Holst, Klaus Rostgaard, Kaspar René Nielsen, and Khoa Manh Dinh
- Subjects
BLOOD-DONOR ,Pulmonary and Respiratory Medicine ,SYMPTOMS ,Immunology ,Population ,Immunoglobulin E ,030207 dermatology & venereal diseases ,03 medical and health sciences ,rhinitis ,0302 clinical medicine ,conjunctivitis ,medicine ,Immunology and Allergy ,Seroprevalence ,EXPOSURE ,Ige sensitization ,education ,Sensitization ,Asthma ,allergic IgE sensitization ,education.field_of_study ,biology ,Inhalation ,business.industry ,Research ,fungi ,ADULTS ,ASSOCIATION ,RC581-607 ,asthma ,medicine.disease ,Allergic conjunctivitis ,PREVALENCE ,ALLERGIC RHINITIS ,LIFE ,medicine.anatomical_structure ,URBAN-RURAL GRADIENT ,030228 respiratory system ,biology.protein ,DONATION ,Immunologic diseases. Allergy ,business ,environment - Abstract
Background Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self-reported ARC represent a primarily sIgE-positive phenotype, while those with either AR or AC represent more diverse phenotypes. Background: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives: The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen-specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods: From the nationwide population-based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results: The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion: Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self-reported ARC represent a primarily sIgE-positive phenotype, while those with either AR or AC represent more diverse phenotypes.
- Published
- 2021