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98 results on '"BIENZ, S."'

1. Randomized controlled pilot study comparing small buccal defects around dental implants treated with a subepithelial connective tissue graft or with guided bone regeneration

Author

Zuercher, A N; https://orcid.org/0000-0002-9941-3491, Strauss, F J; https://orcid.org/0000-0002-5832-7327, Paqué, P N; https://orcid.org/0000-0002-4219-3395, Bienz, S P; https://orcid.org/0000-0002-8562-1580, Jung, R E; https://orcid.org/0000-0003-2055-1320, Thoma, D S; https://orcid.org/0000-0002-1764-7447, Zuercher, A N; https://orcid.org/0000-0002-9941-3491, Strauss, F J; https://orcid.org/0000-0002-5832-7327, Paqué, P N; https://orcid.org/0000-0002-4219-3395, Bienz, S P; https://orcid.org/0000-0002-8562-1580, Jung, R E; https://orcid.org/0000-0003-2055-1320, and Thoma, D S; https://orcid.org/0000-0002-1764-7447

Abstract

AIM To compare subepithelial connective tissue grafts (SCTG) versus guided bone regeneration (GBR) for the treatment of small peri-implant dehiscence defects in terms of profilometric (primary outcome), clinical, and patient-reported outcome measures (PROMs). METHODS Sixteen patients who presented with small buccal bone dehiscences (≤3 mm) following single implant placement were recruited. Following implant placement, buccal bone defect sites were randomly treated either with a SCTG or GBR. Six patients who lacked bone dehiscences after implant placement were assigned to a negative control. Transmucosal healing was applied in all patients. Patients were examined prior (T1) and after (T2) implant placement, at suture removal (T3), at implant impression (T5), at crown delivery (T6), and 12 (T7) months after crown delivery. Measurements included profilometric outcomes, marginal bone levels, buccal bone and soft tissue thickness, PROMs, and clinical parameters. All data were analyzed descriptively. RESULTS The median changes in buccal contour as assessed by profilometric measures between T1 and T5 showed a decrease of 1.84 mm for the SCTG group and 1.06 mm for the GBR group. Between T2 and T7, the median change in the buccal contour amounted to 0.45 mm for SCTG and -0.94 mm (=loss) for GBR. Patients' pain perception tended to be higher in SCTG than in GBR. All peri-implant soft tissue parameters showed healthy oral tissues and no clinically relevant differences between groups. CONCLUSION Within the limitations of this pilot study, treating small peri-implant dehiscence defects with a SCTG might be a viable alternative to GBR. The use of a SCTG tended to result in more stable profilometric outcomes and comparable clinical outcomes to GBR. However, patient-reported outcome measures tended to favor GBR.

Published
2023

2. Randomized controlled pilot study comparing small buccal defects around dental implants treated with a subepithelial connective tissue graft or with guided bone regeneration.

Author

Zuercher, A. N., Strauss, F. J., Paqué, P. N., Bienz, S. P., Jung, R. E., and Thoma, D. S.

Subjects
GUIDED bone regeneration, GUIDED tissue regeneration, CONNECTIVE tissues, DENTAL implants, PATIENTS' attitudes, BONE grafting, TOOTH socket, INTERDENTAL papilla
Abstract

Aim: To compare subepithelial connective tissue grafts (SCTG) versus guided bone regeneration (GBR) for the treatment of small peri‐implant dehiscence defects in terms of profilometric (primary outcome), clinical, and patient‐reported outcome measures (PROMs). Methods: Sixteen patients who presented with small buccal bone dehiscences (≤3 mm) following single implant placement were recruited. Following implant placement, buccal bone defect sites were randomly treated either with a SCTG or GBR. Six patients who lacked bone dehiscences after implant placement were assigned to a negative control. Transmucosal healing was applied in all patients. Patients were examined prior (T1) and after (T2) implant placement, at suture removal (T3), at implant impression (T5), at crown delivery (T6), and 12 (T7) months after crown delivery. Measurements included profilometric outcomes, marginal bone levels, buccal bone and soft tissue thickness, PROMs, and clinical parameters. All data were analyzed descriptively. Results: The median changes in buccal contour as assessed by profilometric measures between T1 and T5 showed a decrease of 1.84 mm for the SCTG group and 1.06 mm for the GBR group. Between T2 and T7, the median change in the buccal contour amounted to 0.45 mm for SCTG and −0.94 mm (=loss) for GBR. Patients' pain perception tended to be higher in SCTG than in GBR. All peri‐implant soft tissue parameters showed healthy oral tissues and no clinically relevant differences between groups. Conclusion: Within the limitations of this pilot study, treating small peri‐implant dehiscence defects with a SCTG might be a viable alternative to GBR. The use of a SCTG tended to result in more stable profilometric outcomes and comparable clinical outcomes to GBR. However, patient‐reported outcome measures tended to favor GBR. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Enantioselective Synthesis of Di-, Tri-, and Tetrasubstituted Allenylsilanes

Author

Guintchin, B. K. and Bienz, S.

Abstract

A number of differently substituted allenylsilanes were prepared by cuprate substitution of α-acetoxy- and α-mesyloxypropargylic silanes. The reactions were shown to proceed stereospecifically by the attack of the nucleophile anti to the leaving group.

Published
2004

27. New Silicon Groups as Potential Chiral Auxiliaries. Synthesis and Highly Selective Chiral 1,6-Induction in 1,2-Additions to Acylsilanes

Author

Gassmann, S., Guintchin, B., and Bienz, S.

Abstract

Chiral silicon groups possessing an asymmetric and chelating alkoxymethyl substituent at silicon have been prepared, and it was shown that these groups may have substantial utility as stereodirecting auxiliaries. For the 1,2-addition of organometallic species to chiral acylsilanes, auxiliaries with a single stereogenic center at position 6 with respect to the reactive carbonyl C atom proved particularly valuable. Compounds with such auxiliaries are easily accessible in enantiomerically pure form, and the chiral groups induce π-facial selectivities of as high as 98:2. In an example it is shown that chiral 1,6-induction may dominate over 1,5-induction.

Published
2001

28. Synthesis and Characterization of 1,2-Disubstituted Vinylsilanes and Their Geometric Differentiation with <SUP>3</SUP>J(<SUP>29</SUP>Si,<SUP>1</SUP>H)-Coupling Constants. Application of a Novel Heteronuclear J-Resolved NMR Experiment

Author

Bratovanov, S., Kozminski, W., Fassler, J., Molnar, Z., Nanz, D., and Bienz, S.

Abstract

The 3J(29Si,1H)-coupling constants of a number of vinylsilanes have been accurately determined with the ACT-J-NMR experiment. For all investigated samples the values of the 3Jtrans-coupling constants were found to be significantly larger than the corresponding values of the 3Jcis-coupling constants (8.8−20.5 Hz versus 3.1−11.9 Hz). Since substituent effects were characterized over a wide range, a conclusive assignment of the double-bond geometry of a particular vinylsilane by means of a single 3J(29Si,1H)-coupling constant is now possible even though the ranges of the 3Jcis- and the 3Jtrans-values overlap.

Published
1997

48. ChemInform Abstract: A Novel NO2/OH Exchange in α‐Nitro Ketones: A Mechanistic Investigation.

Author

YURDAKUL, A., GURTNER, C., JUNG, E.‐S., LORENZI‐RIATSCH, A., LINDEN, A., GUGGISBERG, A., BIENZ, S., and HESSE, M.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1998
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49. Solid-phase synthesis of cyclic polyamines

Author

Pascal Bisegger, Nikolay Manov, Stefan Bienz, University of Zurich, and Bienz, S

Subjects
chemistry.chemical_classification, 10120 Department of Chemistry, Primary (chemistry), 1303 Biochemistry, 3002 Drug Discovery, Organic Chemistry, Biochemistry, Solid-phase synthesis, chemistry, Intramolecular force, Drug Discovery, 540 Chemistry, Organic chemistry, SN2 reaction, Alkyl, 1605 Organic Chemistry
Abstract

A method for the synthesis of cyclic polyamines based on solid-phase chemistry is shown. Linear polyamines are stepwise synthesized on solid support from the center by repetitive alkylations at benzylic N-atoms. Cyclizations at the resins were effected conventionally by direct intramolecular SN2 reactions between sulfonyl-protected terminal amino groups and primary alkyl bromides or by intramolecular Mitsunobu reactions between sulphonamides and primary alcohols. Particularly the latter transformation proved to be powerful for the construction of medium- as well as large-sized rings.

Published
2008
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