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2,732 results on '"BHATIA, SMITA"'

7. Inflammation-related proteins as biomarkers of treatment-related behavioral symptoms: A longitudinal study of breast cancer patients and age-matched controls

Author

Patel, Sunita K, Breen, Elizabeth C, Paz, I Benjamin, Kruper, Laura, Mortimer, Joanne, Wong, F Lennie, Bhatia, Smita, Irwin, Michael R, and Behrendt, Carolyn E

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Behavioral and Social Science, Clinical Research, Cancer, Aging, Pain Research, Chronic Pain, Breast Cancer, Clinical sciences, Immunology
Abstract

BackgroundBehavioral symptoms in breast cancer (BC) survivors have been attributed to cancer treatment and resulting inflammation. However, studies linking behavioral symptoms to BC treatment have observed patients only after some treatment. Our prospective study with pre-treatment baseline investigates post-treatment changes in inflammation-related biomarkers and whether those changes correlate with changes in symptoms.MethodsParticipants were postmenopausal women, newly-diagnosed with stage 0-3 BC before any treatment (n = 173 "patients"), and age-matched women without cancer (n = 77 "controls"), who were assessed on plasma markers [soluble tumor necrosis factor receptor type 2 (sTNF-RII), interleukin (IL)-6, IL-1 receptor antagonist (IL-1RA), C-reactive protein (CRP)]) and symptoms (Physical Functioning, Pain, Attention/concentration, Perceived Cognitive Problems, Fatigue, Sleep Insufficiency, Depression). Participants were assessed again 1 month, 1 year, and 2 years after completing primary treatment or similar interval in controls. Generalized linear mixed models tested 4 treatments (surgery alone or with chemotherapy, radiation, or both) for association with change per marker. Joint models tested change per marker for association with change per symptom. Models considered demographic, socioeconomic, and clinical covariates. False Discovery Rate method controlled risk of error from multiple hypotheses.ResultsAt one month post-completion of treatment, sTNF-RII and IL-6 were elevated by all BC treatments, as were IL-1RA and CRP after surgery alone (all, p

Published
2023

11. Late morbidity and mortality after autologous blood or marrow transplantation for lymphoma in children, adolescents and young adults—a BMTSS report

Author

Holmqvist, Anna Sällfors, Meng, Qingrui, Dai, Chen, Hageman, Lindsey, Landier, Wendy, Wu, Jessica, Francisco, Liton F., Ross, Elizabeth Schlichting, Balas, Nora, Bosworth, Alysia, Te, Hok Sreng, Bhatia, Ravi, Rosenthal, Joseph, Wong, F. Lennie, Weisdorf, Daniel, Armenian, Saro H., and Bhatia, Smita

Published
2024
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13. Inflated expectations: Rare-variant association analysis using public controls

Author

Kim, Jung, Karyadi, Danielle M, Hartley, Stephen W, Zhu, Bin, Wang, Mingyi, Wu, Dongjing, Song, Lei, Armstrong, Gregory T, Bhatia, Smita, Robison, Leslie L, Yasui, Yutaka, Carter, Brian, Sampson, Joshua N, Freedman, Neal D, Goldstein, Alisa M, Mirabello, Lisa, Chanock, Stephen J, Morton, Lindsay M, Savage, Sharon A, and Stewart, Douglas R

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Motivation, High-Throughput Nucleotide Sequencing, Polymorphism, Single Nucleotide, Software, General Science & Technology
Abstract

The use of publicly available sequencing datasets as controls (hereafter, "public controls") in studies of rare variant disease associations has great promise but can increase the risk of false-positive discovery. The specific factors that could contribute to inflated distribution of test statistics have not been systematically examined. Here, we leveraged both public controls, gnomAD v2.1 and several datasets sequenced in our laboratory to systematically investigate factors that could contribute to the false-positive discovery, as measured by λΔ95, a measure to quantify the degree of inflation in statistical significance. Analyses of datasets in this investigation found that 1) the significantly inflated distribution of test statistics decreased substantially when the same variant caller and filtering pipelines were employed, 2) differences in library prep kits and sequencers did not affect the false-positive discovery rate and, 3) joint vs. separate variant-calling of cases and controls did not contribute to the inflation of test statistics. Currently available methods do not adequately adjust for the high false-positive discovery. These results, especially if replicated, emphasize the risks of using public controls for rare-variant association tests in which individual-level data and the computational pipeline are not readily accessible, which prevents the use of the same variant-calling and filtering pipelines on both cases and controls. A plausible solution exists with the emergence of cloud-based computing, which can make it possible to bring containerized analytical pipelines to the data (rather than the data to the pipeline) and could avert or minimize these issues. It is suggested that future reports account for this issue and provide this as a limitation in reporting new findings based on studies that cannot practically analyze all data on a single pipeline.

Published
2023

19. Genome-Wide Association Study of Pregnancy in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study.

Author

Rotz, Seth J, Worley, Sarah, Hu, Bo, Bazeley, Peter, Baedke, Jessica L, Hudson, Melissa M, Kuo, Dennis J, Oeffinger, Kevin C, Robison, Leslie L, Sahoo, Debashis, Wang, Fan, Yasui, Yutaka, Armstrong, Gregory T, and Bhatia, Smita

Subjects
Contraception/Reproduction, Genetics, Human Genome, Pediatric, Pediatric Cancer, Prevention, Cancer, Infertility, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Cancer Survivors, Child, Cohort Studies, Female, Genome-Wide Association Study, Humans, Neoplasms, Pregnancy, Quality of Life, Medical and Health Sciences, Epidemiology
Abstract

BackgroundGonadotoxic treatment-related infertility has a significant impact on quality of life in childhood cancer survivors. Genome-wide association analyses to delineate the risk of infertility in childhood cancer survivors have not been previously reported.MethodsLeveraging genotype data from a large survivor cohort, the Childhood Cancer Survivor Study (CCSS), we investigated the role of SNPs on future pregnancy or siring a pregnancy in survivors without pelvic, testicular, or brain radiation who had ever been married. We calculated sex-stratified hazard ratios, using Cox proportional hazards modeling, adjusting for birth cohort (before 1965 vs. 1965 or later) and doses of relevant chemotherapies; replication was attempted in the independent St. Jude Lifetime Cohort study (SJLIFE).ResultsIn the CCSS cohort, nine SNPs were found to be suggestive (P < 10-7) or statistically significantly (P < 5 × 10-8) associated with pregnancy, however, none of the SNPs were replicated in SJLIFE. Cohorts differed based on the overall pregnancy rate, frequency of sterilizing procedures, and birth cohort.ConclusionsWe were not able to replicate our findings of SNPs associated with pregnancy in childhood cancer survivors.ImpactFuture attempts at replication should be considered in cohorts treated in a comparable era. In addition, understanding the role of genetics in fertility in childhood cancer survivors may be better approached using more advanced sequencing techniques.

Published
2022

20. Leveraging Clinical Trial Populations and Data from the Children's Oncology Group for Cancer Survivorship Research.

Author

Chow, Eric J, Winestone, Lena E, Lupo, Philip J, Diller, Lisa R, Henderson, Tara O, Kadan-Lottick, Nina S, Levine, Jennifer M, Ness, Kirsten K, Bhatia, Smita, and Armenian, Saro H

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Pediatric Cancer, Patient Safety, Pediatric Research Initiative, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Rare Diseases, Cancer, Prevention, Good Health and Well Being, Adolescent, Cancer Survivors, Child, Delivery of Health Care, Humans, National Cancer Institute (U.S.), Neoplasms, Research, United States, Medical and Health Sciences, Epidemiology, Biomedical and clinical sciences, Health sciences
Abstract

Children and adolescents diagnosed with cancer can now expect an average 85% 5-year overall survival, with significant improvements in longer-term morbidity and mortality reported over the past several decades. However, the long-term impact of therapeutic agents and modalities introduced in recent years remains unclear and will require dedicated follow-up in the years ahead. The Children's Oncology Group (COG), a part of the NCI's National Clinical Trials Network, with over 200 sites across North America and beyond, enrolls more than 10,000 patients onto research protocols annually, inclusive of first-line clinical trials and nontherapeutic studies. COG provides a platform to conduct survivorship research with several unique strengths: (i) a huge catchment to ascertain relatively rare but important adverse events, (ii) study populations that are otherwise too rare to study in smaller consortia, including access to highly diverse patient populations, (iii) long-term follow-up of clinical trial populations linked to the original trial data, and (iv) a natural platform for intervention research. Enhancements in COG infrastructure facilitate survivorship research, including a COG patient registry (Project:EveryChild), availability of a long-term follow-up tracking resource, and successful deployment of various remote-based study procedures to reduce the burden on participants and participating institutions.

Published
2022

29. Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy

Author

Singh, Purnima, Zhou, Liting, Shah, Disheet A., Cejas, Romina B., Crossman, David K., Jouni, Mariam, Magdy, Tarek, Wang, Xuexia, Sharafeldin, Noha, Hageman, Lindsey, McKenna, Donald E., Horvath, Steve, Armenian, Saro H., Balis, Frank M., Hawkins, Douglas S., Keller, Frank G., Hudson, Melissa M., Neglia, Joseph P., Ritchey, A. Kim, Ginsberg, Jill P., Landier, Wendy, Burridge, Paul W., and Bhatia, Smita

Published
2023
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31. Long-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors

Author

Hudson, Melissa M, Bhatia, Smita, Casillas, Jacqueline, Landier, Wendy, Rogers, Zora R, Allen, Carl, Harper, James, Hord, Jeffrey, Jain, Juhi, Warwick, Anne, Wetmore, Cynthia, Yates, Amber, Lipton, Jeffrey, Wilson, Hope, Leavey, Patrick, Billett, Amy, DiPaola, Jorge, Graham, Doug, Hastings, Caroline, Matthews, Dana, Pace, Betty, Stork, Linda, Velez, Maria C, and Wechsler, Dan

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Nursing, Health Sciences, Clinical Research, Pediatric, Pediatric Cancer, Cancer, Prevention, Behavioral and Social Science, Pediatric Research Initiative, Good Health and Well Being, Adolescent, Adult, Aftercare, Cancer Survivors, Child, Delivery of Health Care, Follow-Up Studies, Humans, Male, Neoplasms, Survivors, Young Adult, SECTION ON HEMATOLOGY/ONCOLOGY, CHILDREN’S ONCOLOGY GROUP, AMERICAN SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY, Medical and Health Sciences, Psychology and Cognitive Sciences, Pediatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults with a cancer diagnosis today. Notably, this growing population remains vulnerable to a variety of long-term therapy-related sequelae. Systematic ongoing follow-up of these patients is, therefore, important to provide for early detection of and intervention for potentially serious late-onset complications. In addition, health counseling and promotion of healthy lifestyles are important aspects of long-term follow-up care to promote risk reduction for physical and emotional health problems that commonly present during adulthood. Both general and subspecialty health care providers are playing an increasingly important role in the ongoing care of childhood cancer survivors, beyond the routine preventive care, health supervision, and anticipatory guidance provided to all patients. This report is based on the guidelines that have been developed by the Children's Oncology Group to facilitate comprehensive long-term follow-up of childhood, adolescent, and young adult cancer survivors (www.survivorshipguidelines.org).

Published
2021

32. Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors: A Report From COG-ALTE03N1, BMTSS, and CCSS

Author

Sharafeldin, Noha, Zhou, Liting, Singh, Purnima, Crossman, David K., Wang, Xuexia, Hageman, Lindsey, Landier, Wendy, Blanco, Javier G., Burridge, Paul W., Sapkota, Yadav, Yasui, Yutaka, Armstrong, Gregory T., Robison, Leslie L., Hudson, Melissa M., Oeffinger, Kevin, Chow, Eric J., Armenian, Saro H., Weisdorf, Daniel J., and Bhatia, Smita

Published
2023
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33. Development and validation of age-specific risk prediction models for primary ovarian insufficiency in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study and St Jude Lifetime Cohort

Author

Im, Cindy, Lu, Zhe, Mostoufi-Moab, Sogol, Delaney, Angela, Yu, Lin, Baedke, Jessica L, Han, Yutong, Sapkota, Yadav, Yasui, Yutaka, Chow, Eric J, Howell, Rebecca M, Bhatia, Smita, Hudson, Melissa M, Ness, Kirsten K, Armstrong, Gregory T, Nathan, Paul C, and Yuan, Yan

Published
2023
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38. Cardiovascular Risk Factor Disparities in Adult Survivors of Childhood Cancer Compared With the General Population

Author

Noyd, David H., Liu, Qi, Yasui, Yutaka, Chow, Eric J., Bhatia, Smita, Nathan, Paul C., Landstrom, Andrew P., Tonorezos, Emily, Casillas, Jacqueline, Berkman, Amy, Ness, Kirsten K., Mulrooney, Daniel A., Leisenring, Wendy M., Howell, Carrie R., Shoag, Jamie, Kirchhoff, Anne, Howell, Rebecca M., Gibson, Todd M., Zullig, Leah L., Armstrong, Gregory T., and Oeffinger, Kevin C.

Published
2023
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46. Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding

Author

Lee, Olivia W., Rodrigues, Calvin, Lin, Shu-Hong, Luo, Wen, Jones, Kristine, Brown, Derek W., Zhou, Weiyin, Karlins, Eric, Khan, Sairah M., Baulande, Sylvain, Raynal, Virginie, Surdez, Didier, Reynaud, Stephanie, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetête, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Pierron, Gaelle, Gaspar, Nathalie, Corradini, Nadège, Marec-Bérard, Perrine, Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Manning, Michelle, Wyatt, Kathleen, Yeager, Meredith, Chari, Raj, Leisenring, Wendy M., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Armstrong, Gregory T., Bhatia, Smita, Robison, Leslie L., Yasui, Yutaka, Romero-Pérez, Laura, Hartmann, Wolfgang, Metzler, Markus, Diver, W. Ryan, Lori, Adriana, Freedman, Neal D., Hoover, Robert N., Morton, Lindsay M., Chanock, Stephen J., Grünewald, Thomas G.P., Delattre, Olivier, and Machiela, Mitchell J.

Published
2023
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