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1. La violenza fra minori: il bullismo avanza La violence chez les jeunes : le harcèlement en milieu scolaire augmente Violence amongst youth: bullying is growing

Author

Bertocchi F.

Subjects
bullying, cyberbullying, Social pathology. Social and public welfare. Criminology, HV1-9960
Abstract

29 Settembre 2018: “Lignano, minorenni pestano coetaneo e postano video in rete”; 30 Ottobre 2018: “Bullismo, a Vimercate prof aggredita con le sedie dai suoi studenti”; 5 Novembre 2018: “Lecco, difende il figlio dai bulli che lo tormentano: 53enne pestato dal branco”; 6 novembre 2018: “Bullismo a Ravenna, minacce col coltello e molestie sessuali in prima media”; 10 Novembre 2018: “Omofobia, 17enne aggredito e insultato in piazza a Brindisi: denunciati due ragazzi”; 13 Novembre 2018: “Bulli al compleanno, denunciati per violenza sessuale”; 14 Novembre 2018: “Prof aggredita in classe a sediate”; 24 Novembre 2018: “Bullismo, quattro denunciati Erba: botte a un coetaneo per avere 250 euro”; 29 Novembre 2018: “Lodi, bullizzano 15enne e diffondono il video: minori denunciati per trattamento illecito di dati personali”; 7 Dicembre 2018: “Torino, in classe con una mazza da hockey per vendicarsi dei bulli che lo avevano preso in giro”. Questi sono solo alcuni dei più recenti titoli di cronaca che ci riportano un quadro allarmante del fenomeno della violenza in età evolutiva, sintomo del forte disagio vissuto dai giovani d’oggi, non più confinabile in ambiti e contesti di marginalità e di disagio socio-economico. In questo articolo si esplora la complessa realtà della violenza fra minori, descrivendone tutte le possibili sfaccettature e cercando di fornire una risposta plausibile a un fenomeno così complesso e multidimensionale quale è il bullismo. Résumé 29 septembre 2018 : « Lignano (Italie), des mineurs frappent un garçon de leur âge et en publient la vidéo sur les réseaux sociaux » ; 30 octobre 2018 : « Harcèlement en milieu scolaire, à Vimercate (Italie) un professeur est attaquée avec des chaises par ses étudiants » ; 5 novembre 2018 : « Lecco (Italie), il défend son fils des enfants qui le tourmentent : un homme de 53 ans battu par une bande » ; 6 novembre 2018 : « Harcèlement en milieu scolaire à Ravenne (Italie), menaces au couteau et harcèlement sexuel en 6e » ; 10 novembre 2018 : « Homophobie, un garçon de 17 ans attaqué et insulté en pleine rue à Brindisi (Italie) : deux garçons signalés au Parquet » ; 13 novembre 2018 : « Brutes à une fête d’anniversaire signalés au Parquet pour violences sexuelles » ; 14 novembre 2018 : « Professeur attaquée en classe à coups de chaises » ; 24 novembre 2018 : « Harcèlement en milieu scolaire à Erba (Italie), quatre garçons signalés au Parquet : ils ont battu un camarade pour 250 Euros » ; 29 novembre 2018 : « Lodi (Italie), ils harcèlent un garçon de 15 ans et en publient la vidéo : mineurs signalés au Parquet pour traitement illicite de données à caractère personnel » ; 7 décembre 2018 : « Turin (Italie), un garçon entre dans la classe armé d’une crosse de hockey pour se venger de ses harceleurs qui s’étaient moqués de lui ». Ce ne sont là que quelques-uns des exemples les plus récents qui ont fait les gros titres des journaux et qui brossent un tableau alarmant du phénomène de la violence chez les enfants et les adolescents. C’est le signe d’un malaise croissant dont souffrent les jeunes d’aujourd’hui qui va au-delà de la marginalité et des milieux socio-économiques défavorisés. L’auteur de cet article analyse la réalité complexe de la violence chez les jeunes, en essayant d’en décrire toutes les facettes possibles et d’apporter une réponse plausible à un phénomène aussi composite et multidimensionnel que le harcèlement en milieu scolaire. Abstract 29 September 2018: “In Lignano (Italy), minors beat a boy of the same age and post a video on it on social networks”; 30 October 2018: “Bullying, in Vimercate (Italy) a teacher has been attacked with chairs by her students”; 5 November 2018: “In Lecco (Italy), a father was protecting his son from bullies who tormented him: a 53-year-old has been beaten by gang”; 6 November 2018: “Bullying in Ravenna (Italy), threats with a knife and sexual harassment at the first year of a middle school”; 10 November 2018: “Homophobia, a 17-year-old has been attacked and insulted in a central square of Brindisi (Italy): two boys were reported”; 13 November 2018: “Bullies at a birthday party were reported for sexual violence”; 14 November 2018: “A teacher has been attacked with chairs in the classroom”; 24 November 2018: “Bullying in Erba (Italy), four people were reported: they were fighting with a boy of the same age in order to steal 250 Euros from him”; “29 November 2018: “In Lodi (Italy), a 15-year-old was bullied and a video was posted on social networks: minors were reported for unlawful possession of personal data”; 7 December 2018: “In Torino (Italy), a boy was going in the classroom armed with a hockey stick to take revenge on bullies who had made fun of him”. These are just some examples of the most recent headlines which describe an alarming picture of the phenomenon of violence among children and adolescents. This is a symptom of the serious malaise experienced by young people nowadays that does not originate only in marginalization or poor socio-economic background. In this article, the author analyses the complex reality of violence amongst young people, trying to describe every possible facet and to give possible answers to a phenomenon as complex and multi-dimensional as bullying.

Published
2019
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10. Contributors

Author

Angeli, D., primary, Bartosiewicz, Y., additional, Bassini, S., additional, Bertocchi, F., additional, Castelliti, D., additional, Cheng, X., additional, Daubner, M., additional, De Moerloose, L., additional, De Ridder, J., additional, Degroote, J., additional, Del Nevo, A., additional, Di Piazza, I., additional, Duponcheel, M., additional, Eckert, S., additional, Fellmoser, F., additional, Forgione, N., additional, Franke, S., additional, Geffray, C., additional, Gerschenfeld, A., additional, Grishchenko, D., additional, Hering, W., additional, Hu, R., additional, Jäger, W., additional, Jeltsov, M., additional, Kennedy, G., additional, Koloszar, L., additional, Kööp, K., additional, Krauter, N., additional, Kudinov, P., additional, Lorusso, P., additional, Marinari, R., additional, Martelli, D., additional, Merzari, E., additional, Mickus, I., additional, Moreau, V., additional, Oder, J., additional, Pacio, J., additional, Pesetti, A., additional, Planquart, P., additional, Pointer, W.D., additional, Polidori, M., additional, Roelofs, F., additional, Rohde, M., additional, Rozzia, D., additional, Shams, A., additional, Spaccapaniccia, C., additional, Stalio, E., additional, Stieglitz, R., additional, Tarantino, M., additional, Thomas, J., additional, Tiselj, I., additional, Van Tichelen, K., additional, Vierendeels, J., additional, Wetzel, T., additional, and Wondrak, T., additional

Published
2019
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12. La risonanza magnetica nella scienza degli alimenti. Con e-book

Author

Mannina, L., Sobolev, A. P., Proietti, N., Di Tullio, V., Angilè, F., Bellomaria, A., Bertelli, D., Bertocchi, F., Caligiani, L. R., Mucci, A., Righi, V., Tenori, . L., and Urbinati, E.

Subjects
risonanza magnetica, NMR, Alimenti, risonanza magnetica, food, food, Alimenti, NMR
Published
2023

18. On Coherent Structures, Flow-Induced Vibrations, and Migratory Flow

Author

Bertocchi, F., Kloosterman, J.L., Rohde, M., and Delft University of Technology

Subjects
Cross-flow, Wire wrapped, Coherent structures, Fluid-Structure Interactions, Particle Image Velocimetry, Laser Doppler Anemometry, Hexagonal bundle
Abstract

Flows in rod bundles are common to many industrial applications such as heat exchangers or some types of nuclear reactors. The core of many classes of nuclear reactors can be easily sketched as a bundle of rods, the fuel pins, inmmersed in an axial ow of coolant that removes the heat produced by the fission reaction. Coupling this geometry to an axial ow can trigger periodical vortices, known as large coherent structures or gap vortex streets, that move on both sides of the gaps between the rods. By crossing the gap (cross-ow), these vortices may enhance the heat removal mechanism, thus improving the performance of the reactor. However, coherent structures cause velocity oscillations in the ow that may induce vibrations of the fuel rods, leading to their long term damage. The length (or wavelength) of coherent structures is a key parameter for understanding the interplay between these vortices and the vibrations that may be triggered on the rods. Their wavelength determines the frequency of the velocity oscillations in the uid, hence of the external force imposed on the rods. One of the reactor designs belonging to the next generation (Gen-IV) of nuclear reactors is the Liquid Metal Fast Breeder Reactor (LMFBR). This reactor has the fuel rods in the core arranged in a hexagonal matrix. In this design, a wire is helicoidally wrapped around each fuel rod to keep them separated from each other. The presence of the wire diverts part of the more turbulent ow from the bulk towards the gap between the rods, where the ow would be otherwise less turbulent. This enhances the heat exchange and avoids hot spots on the fuel cladding. A phenomenon known as migratory ow has been observed in rod bundles with wire spacers. In the presence of migratory ow, the uid is diverted from the gap towards the main subchannel and it bends against the helicoid path of the wire, thus leading to a very complex ow, where part of the uid follows the wire direction and part moves against it, away from the gap. Although this behaviour was _rst observed years ago, the governing mechanism is not clear yet. Explaining migratory ow is thus a fundamental step towards a general understanding of the mixing and mass transfer phenomena in rod bundles in the presence of helicoid wires.

Published
2020

19. Investigation of the gap vortex street in densely packed tube arrays in axial flow using CFD and experiments

Author

Dolfen, Henri, Bertocchi, F., Rohde, M., Vierendeels, Jan, Degroote, Joris, Owen, Roger, de Borst, Rene, Reese, Jason, and Pearce, Chris

Subjects
Physics::Fluid Dynamics, Vortex street, Vortex-induced vibrations, Gap instability
Abstract

Axial flow in tube bundles with small pitch-to-diameter ratio, a geometry encountered in nuclear reactor cores and heat exchangers, often displays periodic fluctuations. A significant velocity discrepancy between the inter-cylinder gap and subchannel center originates from the difference in through-flow area, feeding an instability. As it is associated with velocity-shear, it is similar to the Kelvin-Helmholtz type and the term 'gap instability' is adopted. A vortex street arises and structural vibration of the cylinders might develop due to the fluctuating pressure. Numerical simulations of this phenomenon were performed. The computational domain was constructed to match the most important geometrical features of an experimental setup. The bundle consists of 7 steel tubes in triangular array, placed in a hexagonal conduit. A flexible segment made of silicone is embedded in the central tube, with both extremes clamped to the steel parts of the cylinder. In the experiment, data of the fluctuating velocity was gathered using laser Doppler anemometry measurements. As first step, a completely rigid structure was considered. Unsteady Reynolds-averaged Navier-Stokes (URANS) simulations were used to test if this particular geometry also triggers the gap vortex street, which was the case. The phenomenon clearly appears as oscillations of the velocity components. Subsequently, fluid-structure interaction (FSI) simulations, taking into account the flexible part, allowed to assess the effect of the fluctuating flow field on the structure. A comparison between one-way and two-way coupled simulations was made.

Published
2020

20. Investigation of the gap vortex street in densely packed tube arrays in axial flow using CFD and experiments

Author

Dolfen, Henri (author), Bertocchi, F. (author), Rohde, M. (author), Vierendeels, Jan (author), Degroote, Joris (author), Dolfen, Henri (author), Bertocchi, F. (author), Rohde, M. (author), Vierendeels, Jan (author), and Degroote, Joris (author)

Abstract

Axial flow in tube bundles with small pitch-to-diameter ratio, a geometry encountered in nuclear reactor cores and heat exchangers, often displays periodic fluctuations. A significant velocity discrepancy between the inter-cylinder gap and subchannel center originates from the difference in through-flow area, feeding an instability. As it is associated with velocity-shear, it is similar to the Kelvin-Helmholtz type and the term 'gap instability' is adopted. A vortex street arises and structural vibration of the cylinders might develop due to the fluctuating pressure. Numerical simulations of this phenomenon were performed. The computational domain was constructed to match the most important geometrical features of an experimental setup. The bundle consists of 7 steel tubes in triangular array, placed in a hexagonal conduit. A flexible segment made of silicone is embedded in the central tube, with both extremes clamped to the steel parts of the cylinder. In the experiment, data of the fluctuating velocity was gathered using laser Doppler anemometry measurements. As first step, a completely rigid structure was considered. Unsteady Reynolds-averaged Navier-Stokes (URANS) simulations were used to test if this particular geometry also triggers the gap vortex street, which was the case. The phenomenon clearly appears as oscillations of the velocity components. Subsequently, fluid-structure interaction (FSI) simulations, taking into account the flexible part, allowed to assess the effect of the fluctuating flow field on the structure. A comparison between one-way and two-way coupled simulations was made., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., RST/Reactor Physics and Nuclear Materials

Published
2020

21. Fluid-structure interaction of a 7-rods bundle: Benchmarking numerical simulations with experimental data

Author

Bertocchi, F. (author), Rohde, M. (author), De Santis, D. (author), Shams, A. (author), Dolfen, H. (author), Degroote, J. (author), Vierendeels, J. (author), Bertocchi, F. (author), Rohde, M. (author), De Santis, D. (author), Shams, A. (author), Dolfen, H. (author), Degroote, J. (author), and Vierendeels, J. (author)

Abstract

Fluid flows through rod bundles are observed in many nuclear applications, such as in the core of Gen IV liquid metal fast breeder nuclear reactors (LMFBR). One of the main features of this configuration is the appearance of flow fluctuations in the rod gaps due to the velocity difference in the sub-channels between the rods. On one side, these pulsations are beneficial as they enhance the heat exchange between the rods and the fluid. On the other side, the fluid pulsations might induce vibrations of the flexible fuel rods, a mechanism generally referred to as Flow Induced Vibrations (FIV). Over time, this might result in mechanical fatigue of the rods and rod fretting, which eventually can compromise their structural integrity. Within the SESAME framework, a joint work between Delft University of Technology (TU Delft), Ghent University (UGent), and NRG has been carried out with the aim of performing experimental measurements of FIV in a 7-rods bundle and validate numerical simulations against the obtained experimental data. The experiments performed by TU Delft consisted of a gravity-driven flow through a 7-rods, hexagonal bundle with a pitch-to-diameter ratio P/D=1.11. A section of 200 mm of the central rod was made out of silicone, of which 100 mm were flexible. Flow measurements have been carried out with Laser Doppler Anemometry (LDA) whereas a high-speed camera has measured the vibrations induced on the silicone rod. The numerical simulations made use of the Unsteady Reynolds-averaged Navier-Stokes equations (URANS) approach for the turbulence modelling, and of strongly coupled algorithms for the solution of the fluid-structure interaction (FSI) problems. The measured frequency of the flow pulsations, as well as the mean rod displacement and vibration frequency, have been used to carry out the benchmark., RST/Reactor Physics and Nuclear Materials

Published
2020
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22. On Coherent Structures, Flow-Induced Vibrations, and Migratory Flow: In Liquid Metal Nuclear Reactors

Author

Bertocchi, F. (author) and Bertocchi, F. (author)

Abstract

Flows in rod bundles are common to many industrial applications such as heat exchangers or some types of nuclear reactors. The core of many classes of nuclear reactors can be easily sketched as a bundle of rods, the fuel pins, inmmersed in an axial ow of coolant that removes the heat produced by the fission reaction. Coupling this geometry to an axial ow can trigger periodical vortices, known as large coherent structures or gap vortex streets, that move on both sides of the gaps between the rods. By crossing the gap (cross-ow), these vortices may enhance the heat removal mechanism, thus improving the performance of the reactor. However, coherent structures cause velocity oscillations in the ow that may induce vibrations of the fuel rods, leading to their long term damage. The length (or wavelength) of coherent structures is a key parameter for understanding the interplay between these vortices and the vibrations that may be triggered on the rods. Their wavelength determines the frequency of the velocity oscillations in the uid, hence of the external force imposed on the rods. One of the reactor designs belonging to the next generation (Gen-IV) of nuclear reactors is the Liquid Metal Fast Breeder Reactor (LMFBR). This reactor has the fuel rods in the core arranged in a hexagonal matrix. In this design, a wire is helicoidally wrapped around each fuel rod to keep them separated from each other. The presence of the wire diverts part of the more turbulent ow from the bulk towards the gap between the rods, where the ow would be otherwise less turbulent. This enhances the heat exchange and avoids hot spots on the fuel cladding. A phenomenon known as migratory ow has been observed in rod bundles with wire spacers. In the presence of migratory ow, the uid is diverted from the gap towards the main subchannel and it bends against the helicoid path of the wire, thus leading to a very complex ow, where part of the uid follows the wire direction and part moves against it, away fr, RST/Reactor Physics and Nuclear Materials

Published
2020

23. A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy

Author

Musio, B, Ragone, R, Todisco, S, Rizzuti, A, Latronico, M, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Di Noia, T, Acquotti, D, Airoldi, C, Assfalg, M, Barge, A, Bateman, L, Benevelli, F, Bertelli, D, Bertocchi, F, Bieliauskas, A, Borioni, A, Caligiani, A, Callone, E, Čamra, A, Cesare Marincola, F, Chalasani, D, Consonni, R, Dambruoso, P, Davalli, S, David, T, Diehl, B, Donarski, J, Gil, A, Gobetto, R, Goldoni, L, Hamon, E, Harwood, J, Kobrlová, A, Longobardi, F, Luisi, R, Mallamace, D, Mammi, S, Martin-Biran, M, Mazzei, P, Mele, A, Milone, S, Molero Vilchez, D, Mulder, R, Napoli, C, Ragno, D, Randazzo, A, Rossi, M, Rotondo, A, Šačkus, A, Sáez Barajas, E, Schievano, E, Sitaram, B, Stevanato, L, Takis, P, Teipel, J, Thomas, F, Torregiani, E, Valensin, D, Veronesi, M, Warren, J, Wist, J, Zailer-Hafer, E, Zuccaccia, C, Gallo, V, Musio, Biagia, Ragone, Rosa, Todisco, Stefano, Rizzuti, Antonino, Latronico, Mario, Mastrorilli, Piero, Pontrelli, Stefania, Intini, Nicola, Scapicchio, Pasquale, Triggiani, Maurizio, Di Noia, Tommaso, Acquotti, Domenico, Airoldi, Cristina, Assfalg, Michael, Barge, Alessandro, Bateman, Lorraine, Benevelli, Francesca, Bertelli, Davide, Bertocchi, Fabio, Bieliauskas, Aurimas, Borioni, Anna, Caligiani, Augusta, Callone, Emanuela, Čamra, Ales, Cesare Marincola, Flaminia, Chalasani, Dinesh, Consonni, Roberto, Dambruoso, Paolo, Davalli, Silvia, David, Taylor, Diehl, Bernd, Donarski, James, Gil, Ana M., Gobetto, Roberto, Goldoni, Luca, Hamon, Erwann, Harwood, John S., Kobrlová, Andrea, Longobardi, Francesco, Luisi, Renzo, Mallamace, Domenico, Mammi, Stefano, Martin-Biran, Magali, Mazzei, Pierluigi, Mele, Andrea, Milone, Salvatore, Molero Vilchez, Dolores, Mulder, Roger J., Napoli, Claudia, Ragno, Daniele, Randazzo, Antonio, Rossi, Maria Cecilia, Rotondo, Archimede, Šačkus, Algirdas, Sáez Barajas, Elena, Schievano, Elisabetta, Sitaram, Bhavaraju, Stevanato, Livio, Takis, Panteleimon G., Teipel, Jan, Thomas, Freddy, Torregiani, Elisabetta, Valensin, Daniela, Veronesi, Marina, Warren, John, Wist, Julien, Zailer-Hafer, Elina, Zuccaccia, Cristiano, Gallo, Vito, Musio, B, Ragone, R, Todisco, S, Rizzuti, A, Latronico, M, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Di Noia, T, Acquotti, D, Airoldi, C, Assfalg, M, Barge, A, Bateman, L, Benevelli, F, Bertelli, D, Bertocchi, F, Bieliauskas, A, Borioni, A, Caligiani, A, Callone, E, Čamra, A, Cesare Marincola, F, Chalasani, D, Consonni, R, Dambruoso, P, Davalli, S, David, T, Diehl, B, Donarski, J, Gil, A, Gobetto, R, Goldoni, L, Hamon, E, Harwood, J, Kobrlová, A, Longobardi, F, Luisi, R, Mallamace, D, Mammi, S, Martin-Biran, M, Mazzei, P, Mele, A, Milone, S, Molero Vilchez, D, Mulder, R, Napoli, C, Ragno, D, Randazzo, A, Rossi, M, Rotondo, A, Šačkus, A, Sáez Barajas, E, Schievano, E, Sitaram, B, Stevanato, L, Takis, P, Teipel, J, Thomas, F, Torregiani, E, Valensin, D, Veronesi, M, Warren, J, Wist, J, Zailer-Hafer, E, Zuccaccia, C, Gallo, V, Musio, Biagia, Ragone, Rosa, Todisco, Stefano, Rizzuti, Antonino, Latronico, Mario, Mastrorilli, Piero, Pontrelli, Stefania, Intini, Nicola, Scapicchio, Pasquale, Triggiani, Maurizio, Di Noia, Tommaso, Acquotti, Domenico, Airoldi, Cristina, Assfalg, Michael, Barge, Alessandro, Bateman, Lorraine, Benevelli, Francesca, Bertelli, Davide, Bertocchi, Fabio, Bieliauskas, Aurimas, Borioni, Anna, Caligiani, Augusta, Callone, Emanuela, Čamra, Ales, Cesare Marincola, Flaminia, Chalasani, Dinesh, Consonni, Roberto, Dambruoso, Paolo, Davalli, Silvia, David, Taylor, Diehl, Bernd, Donarski, James, Gil, Ana M., Gobetto, Roberto, Goldoni, Luca, Hamon, Erwann, Harwood, John S., Kobrlová, Andrea, Longobardi, Francesco, Luisi, Renzo, Mallamace, Domenico, Mammi, Stefano, Martin-Biran, Magali, Mazzei, Pierluigi, Mele, Andrea, Milone, Salvatore, Molero Vilchez, Dolores, Mulder, Roger J., Napoli, Claudia, Ragno, Daniele, Randazzo, Antonio, Rossi, Maria Cecilia, Rotondo, Archimede, Šačkus, Algirdas, Sáez Barajas, Elena, Schievano, Elisabetta, Sitaram, Bhavaraju, Stevanato, Livio, Takis, Panteleimon G., Teipel, Jan, Thomas, Freddy, Torregiani, Elisabetta, Valensin, Daniela, Veronesi, Marina, Warren, John, Wist, Julien, Zailer-Hafer, Elina, Zuccaccia, Cristiano, and Gallo, Vito

Abstract

Nuclear Magnetic Resonance (NMR) is an analytical technique extensively used in almost every chemical laboratory for structural identification. This technique provides statistically equivalent signals in spite of using spectrometer with different hardware features and is successfully used for the traceability and quantification of analytes in food samples. Nevertheless, to date only a few internationally agreed guidelines have been reported on the use of NMR for quantitative analysis. The main goal of the present study is to provide a methodological pipeline to assess the reproducibility of NMR data produced for a given matrix by spectrometers from different manufacturers, with different magnetic field strengths, age and hardware configurations. The results have been analyzed through a sequence of chemometric tests to generate a community-built calibration system which was used to verify the performance of the spectrometers and the reproducibility of the predicted sample concentrations.

Published
2020

27. Vibrations in a 7-rod bundle subject to axial flow: Simulations and experiments

Author

Dolfen, H. (author), Bertocchi, F. (author), Rohde, M. (author), Degroote, J. (author), Dolfen, H. (author), Bertocchi, F. (author), Rohde, M. (author), and Degroote, J. (author)

Abstract

Being able to quantify mechanical vibrations is of key importance for the safety of nuclear power plants, as they are able to induce damage. In this work, numerical simulations are used to compute water flow and vibration in a densely packed bundle of 7 rods, mimicking an experimental setup. This flow configuration is chosen to resemble the coolant flow through a nuclear reactor core. Because of the wall proximity, a considerable velocity difference between the narrow gaps and the subchannels exists, with an inflection point in the velocity profile. This yields an unstable situation, and large vortices are continuously created through a mechanism similar to the Kelvin–Helmholtz instability. The vortex streets in between the rods are associated with a fluctuating pressure field, causing vibrations of the rods. The experimental setup contains 7 steel cylinders, encased in a hexagonal duct. The central rod contains a section where the steel is replaced by a water-filled silicone tube, clamped at both extremes to the steel rod, and the vibrations of this section are examined. The numerical approach consists of coupled fluid–structure interaction (FSI) simulations, with the flow being modelled using computational fluid dynamics (CFD) and the structure using computational solid mechanics (CSM). The available experimental data consist of Laser Doppler Anemometry (LDA) measurements and high-speed camera footage of the wall movement of the silicone rod. Equivalent data is collected from the numerical simulations. The simulations are repeated for different flow rates. The frequency spectrum of the coherent structures, and the frequency and amplitude of the wall movement are compared for each operating point, as well as their trend as a function of the flow rate. The dominant frequencies found in the simulation results were similar to the experimental results, although slightly higher. They also showed a linear trend, just like the experiments. A larger mismatch was present, Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., RST/Reactor Physics and Nuclear Materials

Published
2019
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28. Understanding migratory flow caused by helicoid wire spacers in rod bundles: An experimental and theoretical study

Author

Bertocchi, F. (author), Rohde, M. (author), Kloosterman, J.L. (author), Bertocchi, F. (author), Rohde, M. (author), and Kloosterman, J.L. (author)

Abstract

The core of a Liquid Metal Fast Breeder Reactor (LMFBR) consists of cylindrical fuel rods that are wrapped by a helicoidally-wound wire spacer to enhance mixing and to prevent damage by fretting. It is known that the liquid metal close to the rod is forced to follow the wires, and that liquid metal further away from the rod crosses the wires (called: migratory flow). This work aims at gaining more insight into the physics behind migratory flow and to provide a model for its bending angle. To this purpose, the flow field in a 7-rods, wire-wrapped, hexagonal bundle with water is studied within the Reynolds number range of 4990–16330 by using Particle Image Velocimetry (PIV). Refraction of the light is minimized by using Fluorinated Ethylene Propylene (FEP), which is a refractive index-matching (RIM) material. These measurements confirm that liquid near the rod follows the helicoid path and bends cross-wise with respect to the wire further away from the rod. A theoretical model for the bending angle of the flow is derived from the Euler equations and shows that the bending is primarily caused by the pressure gradient field induced by the wire. The model shows a very good correspondence with the experimentally obtained PIV data. These findings improve our understanding of the physics at play in rod bundle flows with wrapped wires and can be of assistance in developing practical correlations for frictional pressure losses and heat transfer in such bundles., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., RST/Reactor Physics and Nuclear Materials, RST/Radiation, Science and Technology

Published
2019
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29. Towards validated prediction with RANS CFD of flow and heat transport in a wire-wrap fuel assembly

Author

Roelofs, Ferry (author), Uitslag-Doolaard, Heleen (author), Dovizio, Daniele (author), Mikuz, Blaz (author), Shams, Afaque (author), Bertocchi, F. (author), Rohde, M. (author), Pacio, Julio (author), Di Piazza, Ivan (author), Roelofs, Ferry (author), Uitslag-Doolaard, Heleen (author), Dovizio, Daniele (author), Mikuz, Blaz (author), Shams, Afaque (author), Bertocchi, F. (author), Rohde, M. (author), Pacio, Julio (author), and Di Piazza, Ivan (author)

Abstract

Liquid metal fast reactors (LMFRs) are foreseen to play an important role in the future of nuclear energy, thanks to their increased fuel utilization and safety features profiting from the optimal heat transfer performance of the metallic coolants. Accurate thermal-hydraulic analysis of their fuel assemblies, typically employed with wire-wraps as spacers, is recognized as a crucial scientific and engineering contribution to support the deployment of such technology. This challenges the modeling and simulation community. To this aspect, various reference databases (both experimental and numerical) for different wire-wrapped fuel assembly configurations have been created recently and are being used for validation of engineering simulation approaches based on Reynolds Averaged Navier Stokes (RANS) modelling. These databases include: • 7-pin rod bundle: A detailed experiment with Particle Image Velocimetry (PIV) is performed. In order to allow accurate measurements of the flow topology, a matched-index-of-refraction technique was used employing water as working fluid. • 19-pin bundle: A series of experiments is performed covering a wide range of Reynolds and Peclet numbers as well as thermal powers. The experiments use liquid lead-bismuth eutectic as working fluid. The measurements include pressure drop and local temperatures. • 61-pin rod bundle: This large eddy simulation including conjugate heat transfer from the pin cladding to the coolant allows to bridge the gap from small bundles (less than 37 pins) to large bundles (more than 37 pins). In literature, a fundamental different behavior has been observed for small bundles compared to large bundles. • 127-pin bundle: Isothermal experiments using lead-bismuth eutectic characterizing pressure drop are performed on a full scale fuel assembly representative for the MYRRHA reactor. • Infinite pin bundle: This reference quasi-direct numerical simulation profits from periodicity in all directions. It provides a detailed, Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., RST/Reactor Physics and Nuclear Materials

Published
2019
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30. Experimental investigation on the influence of gap vortex streets on fluid-structure interactions in hexagonal bundle geometries

Author

Bertocchi, F. (author), Rohde, M. (author), Kloosterman, J.L. (author), Bertocchi, F. (author), Rohde, M. (author), and Kloosterman, J.L. (author)

Abstract

Gap vortex streets characterise many industrial applications involving rod bundle flows, such as heat exchangers and nuclear reactors. These structures, known as gap vortex streets, may excite the structural components of the bundle to resonance, leading to fretting and fatigue. This work aims to measure these coherent structures and the resulting displacement and oscillation frequency of the neighbouring rod, to provide unique data for fluid-structure interaction studies and to develop a general correlation for estimating the coherent structure's wavelength. A water loop was built to host a hexagonal rod bundle. Fluorinated Ethylene Prophylene (FEP), a refractive index matching (RIM) material, was used to have undisturbed optical access in the area around the central rod. The flow was measured with Laser Doppler Anemometry (LDA) to detect coherent structures, while the vibrations were measured with a high speed camera. A new correlation for estimating the wavelength of the coherent structures is derived with dimensional analysis based on experimental evidence. The correlation is tested on different geometries: rectangular channels with single or half-rods, and two rod bundles, within the pitch-to-diameter ratio (P/D) range 1.02–1.2. Moreover fluctuations in the flow, given by the detected coherent structures, govern the structural response of the rod. The rod is excited to resonance if these fluctuations match twice the natural frequency of the rod., Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., RST/Reactor Physics and Nuclear Materials, RST/Radiation, Science and Technology

Published
2019
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31. LDA measurements of coherent flow structures and cross-flow across the gap of a compound channel with two half-rods

Author

Bertocchi, F. (author), Rohde, M. (author), Kloosterman, J.L. (author), Bertocchi, F. (author), Rohde, M. (author), and Kloosterman, J.L. (author)

Abstract

The enhancement of heat transfer from fuel rods to coolant of a Liquid Metal Fast Reactor (LMFR) decreases the fuel temperature and, thus, improves the safety margin of the reactor. One of the mechanisms that increases heat transfer consists of large coherent structures that can occur across the gap between adjacent rods. This work investigates the flow between two curved surfaces, representing the gap between two adjacent fuel rods. The aim is to investigate the presence of the aforementioned structures and to provide, as partners in the EU SESAME project, an experimental benchmark for numerical validation to reproduce the thermal hydraulics of Gen-IV LMFRs. The work investigates also the applicability of Fluorinated Ethylene Propylene (FEP) as Refractive Index Matching (RIM) material for optical measurements. The experiments are conducted on two half-rods of 15 mm diameter opposing each other inside a Perspex box with Laser Doppler Anemometry (LDA). Different channel Reynolds numbers between Re = 600 and Re = 30,000 are considered for each P/D (pitch-to-diameter ratio). For high Re, the stream wise velocity root mean square vrms between the two half rods is higher near the walls, similar to common channel flow. As Re decreases, however, an additional central peak in vrms appears at the gap centre, away from the walls. The peak becomes clearer at lower P/D ratios and it also occurs at higher flow rates. Periodical behaviour of the span wise velocity across the gap is revealed by the frequency spectrum and the frequency varies with P/D and decreases with Re. The study of the stream wise velocity component reveals that the structures become longer with decreasing Re. As Re increases, these structures are carried along the flow closer to the gap centre, whereas at low flow rates they are spread over a wider region. This becomes even clearer with smaller gaps., RST/Reactor Physics and Nuclear Materials

Published
2018
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34. Mechanical properties of a thermoplastic adhesive modified with graphene nanoplatelets for automotive applications

Author

Raffaele Ciardiello, Giovanni Belingardi, Martorana, B., Bertocchi, F., Cristiano, F., Zanetti, M., and Brunella, V.

Subjects
Graphene nanoplatelet, Vehicle lightweight design, Reversible adhesive joint, Mechanical properties, Vehicle lightweight design, Reversible adhesive joint, Graphene nanoplatelet, Thermoplastic adhesive, Mechanical properties, Thermoplastic adhesive
Published
2016

35. Valsartan for prevention of recurrent atrial fibrillation

Author

GISSI AF Investigators, Disertori M, Latini R, Barlera S, Franzosi MG, Staszewsky L, Maggioni AP, Lucci D, Di Pasquale G, Tognoni G, Delise P, Bertocchi F, Maiocchi G, Geraci E, Correale E, Lombardi F, Mugelli A, Urso R, Scardi S, Fabbri G, Bartolomei B, Barbato G, Carbonieri E, Ciricugno S, Cosmi F, Pratola C, Rossi MG, Sciarra L, Zeni P, Ceseri M, Atzori A, Bambi F, Baviera M, Bianchini F, Fenicia E, Gianfriddo M, Lonardo G, Luise A, Nota R, Orlando ME, Petrolo R, Pierattini C, Pierota V, Ragno A, Serio C, Tafi A, Tellaroli E, Masson S, Vago T, Gramenzi S, Orso F, Suliman I, Nicolis E, Casola C, Dall'Osso D, Gorini M, Bianchini E, Cabiddu S, Cangioli I, Carnaghi A, Cipressa ML, Cipressa L, Galbiati L, Lorimer A, Priami P, Moccetti T, Vaghi F, Capello AF, Rossetti G, Viada E, Morena L, Delucchi M, Reynaud SG, Allemano P, Massobrio N, Gavazzi A, Taddei F, Mor DA, Bortolini F, Lorini M, Inama G, Durin O, Pirelli S, Spotti A, Procopio R, Cuzzucrea D, Gentile G, Margonato A, Bassanelli G, Tavazzi L, Buzzi MP, Rordorf R, Gualco A, Opasich C, Gronda E, Genovese L, Mattioli R, Donatelli F, Uriarte JA, Rauhe W, Bertagnolli C, Canestrini S, Stefenelli C, Cioffi G, Giovanelli C, Rigatelli G, Boni S, Pasini A, Sitta N, Sacchetta A, Borgese L, Sciascia R, Targa L, Raviele A, Madalosso M, Bertaglia E, Zoppo FC, Capanna M, Fiorencis R, Baracca E, Rossi R, Rossi I, Trappolin R, Morgera T, Barducci E, Baldin MG, Gobbo G, Zardo F, Hrovatin E, Mos L, Vriz O, Sinagra G, Aleksova A, Mazzone C, Fresco C, Rubartelli P, Moroni LA, Camerieri A, Piana M, Mureddu R, Bertoli D, Petacchi R, Pancaldi LG, Gabrieli L, Urbinati S, Pedone C, Di Niro M, Brunelli A, Bosi S, Censi S, Moruzzi P, Pastori P, Modena MG, Malavasi V, Mezzetti M, Melandri F, Zuppiroli A, Fazi A, Testa R, Venturini E, Mazzinghi F, Cosmi D, Santoro GM, Minneci C, Galli M, Paperini L, Bovenzi FM, Cortigiani L, Cocchieri M, Severini D, Arcuri GM, Bagliani G, Bernardinangeli M, Proietti G, Bocconcelli P, Pierantozzi A, Monti F, Giamundo L, Tancredi P, Rossini E, Bianchi C, Bettiol F, Giovannini E, Fera MS, Santini M, Bianconi L, Boccanelli A, Morosetti P, Volpe M, Facciolo C, Vacri A, Romanazzi F, Napoletano C, Piccioni LL, Candelmo F, De Marco G, Arnese MR, Vetrano A, Prinzi D, De Rosa P, Capuano V, Torre S, D'Onofrio A, Ammendola E, Battista R, De Fusco A, Molero U, Iervoglini A, Stefanelli S, Fattore L, Bosco B, Liguori A, Padula G, De Luca I, Sorino M, Colonna P, D'Agostino C, Pierfelice O, Pettinati G, Muscella A, De Lorenzi E, Falco M, Giannattasio C, Baldi N, Clemente MA, D'Alessandro B, Truncellito L, Arabia F, Ciconte VA, Perticone F, Ruberto C, Buffon A, Tomaselli C, De Rosa F, Mazza S, Zampaglione G, Pirozzi AM, Butera A, Levato M, Musacchio D, Polimeni RM, Lacquaniti V, Pulitanò G, Ruggeri A, Provenzano A, Cuccurullo O, Musolino M, Marrari A, Anastasio L, Schiavello M, Comito MG, Gulizia MM, Francese GM, Vasquez L, Coppolino C, Casale A, D'Urso G, Oliva G, Giordano U, Andolina S, Sanfilippo N, Ingrillì F, Accardo S, Grasso S, Buffa L, Serra E., CHIARIELLO, MASSIMO, PERRONE FILARDI, PASQUALE, Delise, P., Bertocchi, F., Maiocchi, G., Geraci, E., Correale, E., Lombardi, F., Mugelli, A., Urso, R., Scardi, S., Fabbri, G., Bartolomei, B., Barbato, G., Carbonieri, E., Ciricugno, S., Cosmi, F., Pratola, C., Rossi, M. G., Sciarra, L., Zeni, P., Ceseri, M., Atzori, A., Bambi, F., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, S., Vago, T., Gramenzi, S., Orso, F., Suliman, I., Nicolis, E., Casola, C., Dall'Osso, D., Gorini, M., Bianchini, E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, T., Vaghi, F., Capello, A. F., Rossetti, G., Viada, E., Morena, L., Delucchi, M., Reynaud, S. G., Allemano, P., Massobrio, N., Gavazzi, A., Taddei, F., Mor, D. A., Bortolini, F., Lorini, M., Inama, G., Durin, O., Pirelli, S., Spotti, A., Procopio, R., Cuzzucrea, D., Gentile, G., Margonato, A., Bassanelli, G., Tavazzi, L., Buzzi, M. P., Rordorf, R., Gualco, A., Opasich, C., Gronda, E., Genovese, L., Mattioli, R., Donatelli, F., Uriarte, J. A., Rauhe, W., Bertagnolli, C., Canestrini, S., Stefenelli, C., Cioffi, G., Giovanelli, C., Rigatelli, G., Boni, S., Pasini, A., Sitta, N., Sacchetta, A., Borgese, L., Sciascia, R., Targa, L., Raviele, A., Madalosso, M., Bertaglia, E., Zoppo, F. C., Capanna, M., Fiorencis, R., Baracca, E., Rossi, R., Rossi, I., Trappolin, R., Morgera, T., Barducci, E., Baldin, M. G., Gobbo, G., Zardo, F., Hrovatin, E., Mos, L., Vriz, O., Sinagra, G., Aleksova, A., Mazzone, C., Fresco, C., Rubartelli, P., Moroni, L. A., Camerieri, A., Piana, M., Mureddu, R., Bertoli, D., Petacchi, R., Pancaldi, L. G., Gabrieli, L., Urbinati, S., Pedone, C., Di Niro, M., Brunelli, A., Bosi, S., Censi, S., Moruzzi, P., Pastori, P., Modena, M. G., Malavasi, V., Mezzetti, M., Melandri, F., Zuppiroli, A., Fazi, A., Testa, R., Venturini, E., Mazzinghi, F., Cosmi, D., Santoro, G. M., Minneci, C., Galli, M., Paperini, L., Bovenzi, F. M., Cortigiani, L., Cocchieri, M., Severini, D., Arcuri, G. M., Bagliani, G., Bernardinangeli, M., Proietti, G., Bocconcelli, P., Pierantozzi, A., Monti, F., Giamundo, L., Tancredi, P., Rossini, E., Bianchi, C., Bettiol, F., Giovannini, E., Fera, M. S., Santini, M., Bianconi, L., Boccanelli, A., Morosetti, P., Volpe, M., Facciolo, C., Vacri, A., Romanazzi, F., Napoletano, C., Piccioni, L. L., Candelmo, F., De Marco, G., Arnese, M. R., Vetrano, A., Prinzi, D., De Rosa, P., Capuano, V., Torre, S., D'Onofrio, A., Ammendola, E., Chiariello, M., Filardi, Pp., Battista, R., De Fusco, A., Molero, U., Iervoglini, A., Stefanelli, S., Fattore, L., Bosco, B., Liguori, A., Padula, G., De Luca, I., Sorino, M., Colonna, P., D'Agostino, C., Pierfelice, O., Pettinati, G., Muscella, A., De Lorenzi, E., Falco, M., Giannattasio, C., Baldi, N., Clemente, M. A., D'Alessandro, B., Truncellito, L., Arabia, F., Ciconte, V. A., Perticone, F., Ruberto, C., Buffon, A., Tomaselli, C., De Rosa, F., Mazza, S., Zampaglione, G., Pirozzi, A. M., Butera, A., Levato, M., Musacchio, D., Polimeni, R. M., Lacquaniti, V., Pulitano, G., Ruggeri, A., Provenzano, A., Cuccurullo, O., Musolino, M., Marrari, A., Anastasio, L., Schiavello, M., Comito, M. G., Gulizia, M. M., Francese, G. M., Vasquez, L., Coppolino, C., Casale, A., D'Urso, G., Oliva, G., Giordano, U., Andolina, S., Sanfilippo, N., Ingrilli, F., Accardo, S., Grasso, S., Buffa, L., Serra, E., Disertori, Marcello, Latini, Roberto, Barlera, Simona, Franzosi, Maria Grazia, Staszewsky, Lidia, Maggioni, Aldo Pietro, Lucci, Donata, Di Pasquale, Giuseppe, Tognoni, Gianni, GISSI AF, Investigator, Disertori, M, Latini, R, Barlera, S, Franzosi, Mg, Staszewsky, L, Maggioni, Ap, Lucci, D, Di Pasquale, G, Tognoni, G, Delise, P, Bertocchi, F, Maiocchi, G, Geraci, E, Correale, E, Lombardi, F, Mugelli, A, Urso, R, Scardi, S, Fabbri, G, Bartolomei, B, Barbato, G, Carbonieri, E, Ciricugno, S, Cosmi, F, Pratola, C, Rossi, Mg, Sciarra, L, Zeni, P, Ceseri, M, Atzori, A, Bambi, F, Baviera, M, Bianchini, F, Fenicia, E, Gianfriddo, M, Lonardo, G, Luise, A, Nota, R, Orlando, Me, Petrolo, R, Pierattini, C, Pierota, V, Ragno, A, Serio, C, Tafi, A, Tellaroli, E, Masson, S, Vago, T, Gramenzi, S, Orso, F, Suliman, I, Nicolis, E, Casola, C, Dall'Osso, D, Gorini, M, Bianchini, E, Cabiddu, S, Cangioli, I, Carnaghi, A, Cipressa, Ml, Cipressa, L, Galbiati, L, Lorimer, A, Priami, P, Moccetti, T, Vaghi, F, Capello, Af, Rossetti, G, Viada, E, Morena, L, Delucchi, M, Reynaud, Sg, Allemano, P, Massobrio, N, Gavazzi, A, Taddei, F, Mor, Da, Bortolini, F, Lorini, M, Inama, G, Durin, O, Pirelli, S, Spotti, A, Procopio, R, Cuzzucrea, D, Gentile, G, Margonato, A, Bassanelli, G, Tavazzi, L, Buzzi, Mp, Rordorf, R, Gualco, A, Opasich, C, Gronda, E, Genovese, L, Mattioli, R, Donatelli, F, Uriarte, Ja, Rauhe, W, Bertagnolli, C, Canestrini, S, Stefenelli, C, Cioffi, G, Giovanelli, C, Rigatelli, G, Boni, S, Pasini, A, Sitta, N, Sacchetta, A, Borgese, L, Sciascia, R, Targa, L, Raviele, A, Madalosso, M, Bertaglia, E, Zoppo, Fc, Capanna, M, Fiorencis, R, Baracca, E, Rossi, R, Rossi, I, Trappolin, R, Morgera, T, Barducci, E, Baldin, Mg, Gobbo, G, Zardo, F, Hrovatin, E, Mos, L, Vriz, O, Sinagra, G, Aleksova, A, Mazzone, C, Fresco, C, Rubartelli, P, Moroni, La, Camerieri, A, Piana, M, Mureddu, R, Bertoli, D, Petacchi, R, Pancaldi, Lg, Gabrieli, L, Urbinati, S, Pedone, C, Di Niro, M, Brunelli, A, Bosi, S, Censi, S, Moruzzi, P, Pastori, P, Modena, Mg, Malavasi, V, Mezzetti, M, Melandri, F, Zuppiroli, A, Fazi, A, Testa, R, Venturini, E, Mazzinghi, F, Cosmi, D, Santoro, Gm, Minneci, C, Galli, M, Paperini, L, Bovenzi, Fm, Cortigiani, L, Cocchieri, M, Severini, D, Arcuri, Gm, Bagliani, G, Bernardinangeli, M, Proietti, G, Bocconcelli, P, Pierantozzi, A, Monti, F, Giamundo, L, Tancredi, P, Rossini, E, Bianchi, C, Bettiol, F, Giovannini, E, Fera, M, Santini, M, Bianconi, L, Boccanelli, A, Morosetti, P, Volpe, M, Facciolo, C, Vacri, A, Romanazzi, F, Napoletano, C, Piccioni, Ll, Candelmo, F, De Marco, G, Arnese, Mr, Vetrano, A, Prinzi, D, De Rosa, P, Capuano, V, Torre, S, D'Onofrio, A, Ammendola, E, Chiariello, Massimo, PERRONE FILARDI, Pasquale, Battista, R, De Fusco, A, Molero, U, Iervoglini, A, Stefanelli, S, Fattore, L, Bosco, B, Liguori, A, Padula, G, De Luca, I, Sorino, M, Colonna, P, D'Agostino, C, Pierfelice, O, Pettinati, G, Muscella, A, De Lorenzi, E, Falco, M, Giannattasio, C, Baldi, N, Clemente, Ma, D'Alessandro, B, Truncellito, L, Arabia, F, Ciconte, Va, Perticone, F, Ruberto, C, Buffon, A, Tomaselli, C, De Rosa, F, Mazza, S, Zampaglione, G, Pirozzi, Am, Butera, A, Levato, M, Musacchio, D, Polimeni, Rm, Lacquaniti, V, Pulitanò, G, Ruggeri, A, Provenzano, A, Cuccurullo, O, Musolino, M, Marrari, A, Anastasio, L, Schiavello, M, Comito, Mg, Gulizia, Mm, Francese, Gm, Vasquez, L, Coppolino, C, Casale, A, D'Urso, G, Oliva, G, Giordano, U, Andolina, S, Sanfilippo, N, Ingrillì, F, Accardo, S, Grasso, S, and Buffa, L

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Tetrazoles, Cardiomegaly, Comorbidity, Placebo, Cardioversion, Double-Blind Method, Recurrence, Multicenter trial, Internal medicine, Angiotensin II Type 1 Receptor Blocker, Cardiovascular Disease, Atrial Fibrillation, medicine, Left atrial enlargement, Diabetes Mellitus, Humans, Sinus rhythm, cardiovascular diseases, Prospective Studies, Tetrazole, Proportional Hazards Models, Aged, business.industry, Medicine (all), Hazard ratio, Atrial fibrillation, Diabetes Mellitu, Valine, General Medicine, Middle Aged, medicine.disease, valsartan, atrial fibrillation, Prospective Studie, Valsartan, Cardiovascular Diseases, cardiovascular system, Cardiology, Proportional Hazards Model, Female, business, Angiotensin II Type 1 Receptor Blockers, medicine.drug, Human
Abstract

BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, and no current therapy is ideal for control of this condition. Experimental studies suggest that angiotensin II-receptor blockers (ARBs) can influence atrial remodeling, and some clinical studies suggest that they may prevent atrial fibrillation. METHODS: We conducted a large, randomized, prospective, placebo-controlled, multicenter trial to test whether the ARB valsartan could reduce the recurrence of atrial fibrillation. We enrolled patients who were in sinus rhythm but had had either two or more documented episodes of atrial fibrillation in the previous 6 months or successful cardioversion for atrial fibrillation in the previous 2 weeks. To be eligible, patients also had to have underlying cardiovascular disease, diabetes, or left atrial enlargement. Patients were randomly assigned to receive valsartan or placebo. The two primary end points were the time to a first recurrence of atrial fibrillation and the proportion of patients who had more than one recurrence of atrial fibrillation over the course of 1 year. RESULTS: A total of 1442 patients were enrolled in the study. Atrial fibrillation recurred in 371 of the 722 patients (51.4%) in the valsartan group, as compared with 375 of 720 (52.1%) in the placebo group (adjusted hazard ratio, 0.97; 96% confidence interval [CI], 0.83 to 1.14; P = 0.73). More than one episode of atrial fibrillation occurred in 194 of 722 patients (26.9%) in the valsartan group and in 201 of 720 (27.9%) in the placebo group (adjusted odds ratio, 0.89; 99% CI, 0.64 to 1.23; P = 0.34). The results were similar in all predefined subgroups of patients, including those who were not receiving angiotensin-converting-enzyme inhibitors. CONCLUSIONS: Treatment with valsartan was not associated with a reduction in the incidence of recurrent atrial fibrillation. (ClinicalTrials.gov number, NCT00376272.) Copyright © 2009 Massachusetts Medical Society.

Published
2009

36. A multicenter, randomized double-blind study of valsartan/hydrochlorothiazide combination versus amlodipine in patients with mild to moderate hypertension

Author

Palatini, P., Malacco, E., Fogari, R., Carretta, Renzo, Bonaduce, D., Bertocchi, F., Mann, J., Condorelli, M, Italian Collaborative Study Group, Palatini, P, Malacco, E, Fogari, R, Carretta, R, Bonaduce, Domenico, Bertocchi, F, Mann, J, Condorelli, M., Palatini, P., Malacco, E., Fogari, R., Carretta, Renzo, Bonaduce, D., Bertocchi, F., Mann, J., Condorelli, M, and Italian Collaborative Study, Group

Subjects
Adult, Male, medicine.medical_specialty, hypertension, Physiology, Urology, Tetrazoles, Blood Pressure, Pharmacology, amlodipine, Severity of Illness Index, Hydrochlorothiazide, Double-Blind Method, Internal Medicine, medicine, Humans, Amlodipine, Thiazide, Antihypertensive Agents, Aged, business.industry, Valine, Middle Aged, Angiotensin II, Valsartan, Drug Combinations, Blood pressure, Treatment Outcome, Tolerability, Hypertension, Valsartan/hydrochlorothiazide, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

Objective To compare the antihypertensive efficacy and tolerability of a once-daily fixed valsartan/hydrochlorothiazide (HCTZ) combination and amlodipine in subjects with mild-to-moderate hypertension. Subjects and setting In this multicentre, double-blind, randomized, comparative trial, 690 patients with sitting systolic blood pressure (BP) > or = 160 mmHg and sitting diastolic BP > or = 95 mmHg at the end of a 2-week placebo wash-out period were randomized to valsartan-based treatment (n = 342) or amlodipine (n = 348). Methods The patients received valsartan 80 mg o.d. or amlodipine 5 mg o.d for 4 weeks; in the case of an unsatisfactory blood pressure response, the treatments could be respectively changed to the fixed combination of valsartan 80 mg + HCTZ 12.5 mg o.d. or amlodipine 10 mg o.d. for a further 8 weeks. Results Both treatment approaches decreased systolic blood pressure and diastolic blood pressure to the same extent. The rate of responders to treatment at the end of fourth week (before up-titration) was 57.4% among the valsartan-treated patients and 61.9% among the amlodipine-treated patients (ns). At the end of the study, the rate of responders was not significantly different between the two groups (74.9 versus 72.1%). Valsartan-based treatment had a slightly lower incidence of adverse events (1.5 versus 5.5%; P = 0.006). Conclusions The results of this trial demonstrate that the valsartan/hydrochlorothiazide combination and amlodipine are equally effective in lowering BP, and that the combination is better tolerated.

Published
2001

37. Valsartan for prevention of recurrent atrial fibrillation (New England Journal of Medicine (2009) 360, (1606-1617))

Author

Delise, P., Bertocchi, F., Maiocchi, G., Geraci, E., Correale, E., Lombardi, F., Mugelli, A., Urso, R., Scardi, S., Fabbri, G., Bartolomei, B., Barbato, G., Carbonieri, E., Ciricugno, S., Cosmi, F., Pratola, C., Rossi, M. G., Sciarra, L., Zeni, P., Ceseri, M., Atzori, A., Bambi, F., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, S., Vago, T., Gramenzi, S., Orso, F., Suliman, I., Nicolis, E., Casola, C., Dall Osso, D., Gorini, M., Bianchini, E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, T., Vaghi, F., Capello, A. F., Rossetti, G., Viada, E., Morena, L., Delucchi, M., Reynaud, S. G., Allemano, P., Massobrio, N., Gavazzi, A., Taddei, F., Mor, D. A., Bortolini, F., Lorini, M., Inama, G., Durin, O., Pirelli, S., Spotti, A., Procopio, R., Cuzzucrea, D., Gentile, G., Margonato, A., Bassanelli, G., Tavazzi, L., Buzzi, M. P., Rordorf, R., Gualco, A., Opasich, C., Gronda, E., Genovese, L., Mattioli, R., Donatelli, F., Uriarte, J. A., Rauhe, W., Bertagnolli, C., Canestrini, S., Stefenelli, C., Cioffi, G., Giovanelli, C., Rigatelli, G., Boni, S., Pasini, A., Sitta, N., Sacchetta, A., Borgese, L., Sciascia, R., Targa, L., Raviele, A., Madalosso, M., Bertaglia, E., Franco Zoppo, Capanna, M., Fiorencis, R., Baracca, E., Rossi, R., Rossi, I., Trappolin, R., Morgera, T., Barducci, E., Baldin, M. G., Gobbo, G., Zardo, F., Hrovatin, E., Mos, L., Vriz, O., Sinagra, G., Aleksova, A., Mazzone, C., Fresco, C., Rubartelli, P., Moroni, L. A., Camerieri, A., Piana, M., Mureddu, R., Bertoli, D., Petacchi, R., Pancaldi, L. G., Gabrieli, L., Urbinati, S., Pedone, C., Di Niro, M., Brunelli, A., Bosi, S., Censi, S., Moruzzi, P., Pastori, P., Modena, M. G., Malavasi, V., Mezzetti, M., Melandri, F., Zuppiroli, A., Fazi, A., Testa, R., Venturini, E., Mazzinghi, F., Cosmi, D., Santoro, G. M., Minneci, C., Galli, M., Paperini, L., Bovenzi, F. M., Cortigiani, L., Cocchieri, M., Severini, D., Arcuri, G. M., Bagliani, G., Bernardinangeli, M., Proietti, G., Bocconcelli, P., Pierantozzi, A., Monti, F., Giamundo, L., Tancredi, P., Rossini, E., Bianchi, C., Bettiol, F., Giovannini, E., Fera, M. S., Santini, M., Bianconi, L., Boccanelli, A., Morosetti, P., Volpe, M., Facciolo, C., Vacri, A., Romanazzi, F., Napoletano, C., Piccioni, L. L., Candelmo, F., Marco, G., Arnese, M. R., Vetrano, A., Prinzi, D., Rosa, P., Capuano, V., Torre, S., D Onofrio, A., Ammendola, E., Chiariello, M., Filardi, Pp, Battista, R., Fusco, A., Molero, U., Iervoglini, A., Stefanelli, S., Fattore, L., Bosco, B., Liguori, A., Padula, G., Luca, I., Sorino, M., Colonna, P., D Agostino, C., Pierfelice, O., Pettinati, G., Muscella, A., Lorenzi, E., Falco, M., Giannattasio, C., Baldi, N., Clemente, M. A., D Alessandro, B., Truncellito, L., Arabia, F., Ciconte, V. A., Perticone, F., Ruberto, C., Buffon, A., Tomaselli, C., Rosa, F., Mazza, S., Zampaglione, G., Pirozzi, A. M., Butera, A., Levato, M., Musacchio, D., Polimeni, R. M., Lacquaniti, V., Pulitano, G., Ruggeri, A., Provenzano, A., Cuccurullo, O., Musolino, M., Marrari, A., Anastasio, L., Schiavello, M., Comito, M. G., Gulizia, M. M., Francese, G. M., Vasquez, L., Coppolino, C., Casale, A., D Urso, G., Oliva, G., Giordano, U., Andolina, S., Sanfilippo, N., Ingrilli, F., Accardo, S., Grasso, S., Buffa, L., Serra, E., Disertori, M., Latini, R., Barlera, S., Franzosi, M. G., Staszewsky, L., Maggioni, A. P., Lucci, D., Di Pasquale, G., Tognoni, G., Delise, P., Bertocchi, F., Maiocchi, G., Geraci, E., Correale, E., Lombardi, F., Mugelli, A., Urso, R., Scardi, S., Fabbri, G., Bartolomei, B., Barbato, G., Carbonieri, E., Ciricugno, S., Cosmi, F., Pratola, C., Rossi, M. G., Sciarra, L., Zeni, P., Ceseri, M., Atzori, A., Bambi, F., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, S., Vago, T., Gramenzi, S., Orso, F., Suliman, I., Nicolis, E., Casola, C., Dall'Osso, D., Gorini, M., Bianchini, E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, T., Vaghi, F., Capello, A. F., Rossetti, G., Viada, E., Morena, L., Delucchi, M., Reynaud, S. G., Allemano, P., Massobrio, N., Gavazzi, A., Taddei, F., Mor, D. A., Bortolini, F., Lorini, M., Inama, G., Durin, O., Pirelli, S., Spotti, A., Procopio, R., Cuzzucrea, D., Gentile, G., Margonato, A., Bassanelli, G., Tavazzi, L., Buzzi, M. P., Rordorf, R., Gualco, A., Opasich, C., Gronda, E., Genovese, L., Mattioli, R., Donatelli, F., Uriarte, J. A., Rauhe, W., Bertagnolli, C., Canestrini, S., Stefenelli, C., Cioffi, G., Giovanelli, C., Rigatelli, G., Boni, S., Pasini, A., Sitta, N., Sacchetta, A., Borgese, L., Sciascia, R., Targa, L., Raviele, A., Madalosso, M., Bertaglia, E., Zoppo, F. C., Capanna, M., Fiorencis, R., Baracca, E., Rossi, R., Rossi, I., Trappolin, R., Morgera, T., Barducci, E., Baldin, M. G., Gobbo, G., Zardo, F., Hrovatin, E., Mos, L., Vriz, O., Sinagra, G., Aleksova, A., Mazzone, C., Fresco, C., Rubartelli, P., Moroni, L. A., Camerieri, A., Piana, M., Mureddu, R., Bertoli, D., Petacchi, R., Pancaldi, L. G., Gabrieli, L., Urbinati, S., Pedone, C., Di Niro, M., Brunelli, A., Bosi, S., Censi, S., Moruzzi, P., Pastori, P., Modena, M. G., Malavasi, V., Mezzetti, M., Melandri, F., Zuppiroli, A., Fazi, A., Testa, R., Venturini, E., Mazzinghi, F., Cosmi, D., Santoro, G. M., Minneci, C., Galli, M., Paperini, L., Bovenzi, F. M., Cortigiani, L., Cocchieri, M., Severini, D., Arcuri, G. M., Bagliani, G., Bernardinangeli, M., Proietti, G., Bocconcelli, P., Pierantozzi, A., Monti, F., Giamundo, L., Tancredi, P., Rossini, E., Bianchi, C., Bettiol, F., Giovannini, E., Fera, M. S., Santini, M., Bianconi, L., Boccanelli, A., Morosetti, P., Volpe, M., Facciolo, C., Vacri, A., Romanazzi, F., Napoletano, C., Piccioni, L. L., Candelmo, F., De Marco, G., Arnese, M. R., Vetrano, A., Prinzi, D., De Rosa, P., Capuano, V., Torre, S., D'Onofrio, A., Ammendola, E., Chiariello, M., Filardi, Pp., Battista, R., De Fusco, A., Molero, U., Iervoglini, A., Stefanelli, S., Fattore, L., Bosco, B., Liguori, A., Padula, G., De Luca, I., Sorino, M., Colonna, P., D'Agostino, C., Pierfelice, O., Pettinati, G., Muscella, A., De Lorenzi, E., Falco, M., Giannattasio, C., Baldi, N., Clemente, M. A., D'Alessandro, B., Truncellito, L., Arabia, F., Ciconte, V. A., Perticone, F., Ruberto, C., Buffon, A., Tomaselli, C., De Rosa, F., Mazza, S., Zampaglione, G., Pirozzi, A. M., Butera, A., Levato, M., Musacchio, D., Polimeni, R. M., Lacquaniti, V., Pulitano, G., Ruggeri, A., Provenzano, A., Cuccurullo, O., Musolino, M., Marrari, A., Anastasio, L., Schiavello, M., Comito, M. G., Gulizia, M. M., Francese, G. M., Vasquez, L., Coppolino, C., Casale, A., D'Urso, G., Oliva, G., Giordano, U., Andolina, S., Sanfilippo, N., Ingrilli, F., Accardo, S., Grasso, S., Buffa, L., Serra, E., Disertori, Marcello, Latini, Roberto, Barlera, Simona, Franzosi, Maria Grazia, Staszewsky, Lidia, Maggioni, Aldo Pietro, Lucci, Donata, Di Pasquale, Giuseppe, and Tognoni, Gianni

Subjects
Medicine (all)
Published
2009

39. AMLODIPINE IN PATIENTS WITH MILD TO MODERATE HYPERTENSION

Author

Palatini P, Malacco E, Fogari R, Carretta R, Bertocchi F, Mann J, BONADUCE, DOMENICO, CONDORELLI, MARIO, Palatini, P, Malacco, E, Fogari, R, Carretta, R, Bonaduce, Domenico, Bertocchi, F, Mann, J, and Condorelli, Mario

Published
2001

41. Valsartan for prevention of recurrent atrial

Author

Disertori, M, Latini, R, Maggioni, Ap, Barlera, S, Di Pasquale, G, Franzosi, Mg, Lucci, D, Staszewsky, L, Tognoni, G, Delise, P, Bertocchi, F, Maiocchi, G, Geraci, E, Correale, E, Lombardi, F, Mugelli, A, Urso, R, Scardi, S, Fabbri, G, Bartolomei, B, Barbato, G, Carbonieri, E, Ciricugno, S, Cosmi, F, Pratola, C, Rossi, Mg, Sciarra, L, Zeni, P, Ceseri, M, Atzori, A, Bambi, F, Baviera, M, Bianchini, F, Cfenicia, E, Gianfriddo, M, Lonardo, G, Luise, A, Nota, R, Orlando, Me, Petrolo, R, Pierattini, C, Pierota, V, Ragno, A, Serio, C, Tafi, A, Tellaroli, E, Masson, S, Vago, T, Gramenzi, S, Orso, F, Suliman, I, Nicolis, E, Casola, C, Dall'Osso, D, Gorini, M, Bianchini, E, Cabiddu, S, Cangioli, I, Carnaghi, A, Cipressa, Ml, Cipressa, L, Galbiati, L, Lorimer, A, Priami, P, Moccetti, T, Vaghi, F, Capello, Af, Rossetti, G, Viada, E, Morena, L, Delucchi, M, Reynaud SG, Allemano, P, Massobrio, N, Gavazzi, A, Taddei, F, Mor, Da, Bortolini, F, Lorini, M, Inama, G, Durin, O, Pirelli, S, Spotti, A, Procopio, R, Cuzzucrea, D, Gentile, G, Margonato, A, Bassanelli, G, Tavazzi, L, Buzzi, Mp, Rordorf, R, Gualco, A, Opasich, C, Gronda, E, Genovese, L, Mattioli, R, Donatelli, F, Uriarte, Ja, Rauhe, W, Bertagnolli, C, Canestrini, S, Stefenelli, C, Cioffi, G, Giovanelli, C, Rigatelli, G, Boni, S, Pasini, A, Sitta, N, Sacchetta, A, Borgese, L, Sciascia, R, Targa L, Raviele, A, Madalosso, M, Bertaglia, E, Zoppo, Fc, Capanna, M, Fiorencis, R, Baracca, E, Rossi, R, Rossi, I, Trappolin, R, Morgera, T, Barducci, E, Baldin, Mg, Gobbo, G, Zardo, F, Hrovatin, E, Mos, L, Vriz, O, Sinagra, G, Aleksova, A, Mazzone, C, Fresco, C, Rubartelli, P, Moroni, La, Camerieri, A, Piana, M, Mureddu, R, Bertoli, D, Petacchi, R, Pancaldi, Lg, Gabrieli, L, Urbinati, S, Pedone, C, Di Niro, M, Brunelli, A, Bosi, S, Censi, S, Moruzzi, P, Pastori, P, Modena, Mg, Malavasi, V, Mezzetti, M, Melandri, F, Zuppiroli, A, Fazi, A, Testa, R, Venturini, E, Mazzinghi, F, Cosmi, D, Santoro, Gm, Minneci, C, Galli, M, Paperini, L, Bovenzi, Fm, Cortigiani, L, Cocchieri, M, Severini, D, Arcuri, Gm, Bagliani, G, Bernardinangeli, M, Proietti, G, Bocconcelli, P, Pierantozzi, A, Monti, F, Giamundo, L, Tancredi, P, Rossini, E, Bianchi, C, Bettiol, F, Giovannini, E, Fera, Ms, Santini, M, Bianconi, L, Boccanelli, A, Morosetti, P, Volpe, M, Facciolo, C, Vacri, A, Romanazzi, F, Napoletano, C, Piccioni, Ll, Candelmo, F, De Marco, G, Arnese, Mr, Vetrano, A, Prinzi, D, De Rosa, P, Capuano, V, Torre, S, D'Onofrio, A, Ammendola, E, Chiariello, M, Filardi, Pp, Battista, R, De Fusco, A, Molero, U, Iervoglini, A, Stefanelli, S, Fattore, L, Bosco, B, Liguori, A, Padula, G, De Luca, I, Sorino, M, Colonna, P, D'Agostino, C, Pierfelice, O, Pettinati, G, Muscella, A, De Lorenzi, E, Falco, M, Giannattasio, C, Baldi, N, Clemente, Ma, D'Alessandro, B, Truncellito, L, Arabia, F, Ciconte, Va, Perticone, F, Ruberto, C, Buffon, A, Tomaselli, C, De Rosa, F, Mazza, S, Zampaglione, G, Pirozzi, Am, Butera, A, Levato, M, Musacchio, D, Polimeni, Rm, Lacquaniti, V, Pulitanò, G, Ruggeri, A, Provenzano, A, Cuccurullo, O, Musolino, M, Marrari, A, Anastasio, L, Schiavello, M, Comito, Mg, Gulizia, Mm, Francese GM, Vasquez, L, Coppolino, C, Casale, A, D'Urso, G, Oliva, G, Giordano, U, Andolina, S, Sanfilippo, N, Ingrillì, F, Accardo, S, Grasso, S, Buffa, L, Bambi, Serra E., Baviera, M., Bianchini, F., Fenicia, E., Gianfriddo, M., Lonardo, G., Luise, A., Nota, R., Orlando, M. E., Petrolo, R., Pierattini, C., Pierota, V., Ragno, A., Serio, C., Tafi, A., Tellaroli, E., Masson, Core Laboratories — S., Latini, R., Vago (Biomarkers), T., Staszewsky, L., Gramenzi (Echocardiography), S., Orso, F., Suliman (Electrocardiography), I., Nicolis, Database Management and Statistics — E., Casola, C., Barlera, S., Dall'Osso, D., Gorini, M., Lucci, D., Regulatory, Administrative, Bianchini, and Secretariat — E., Cabiddu, S., Cangioli, I., Carnaghi, A., Cipressa, M. L., Cipressa, L., Galbiati, L., Lorimer, A., Priami, P., Moccetti, Participating Centers and Investigators — Switzerland: Lugano (T., Rossi, M. G., Vaghi), F., Capello), Italy: Piemonte: Asti (A. F. L., Rossetti, Cuneo (G., Viada, E., Morena), L., Delucchi, Saluzzo (M., Reynaud, S. G., Allemano), P., Massobrio), Torino Valdese (N., Gavazzi, Lombardia: Bergamo (A., Taddei), F., Mor), Brescia (D. A., Bortolini, Chiari (F., Lorini), M., Inama, Crema (G., Durin), O., Pirelli, Cremona (S., Spotti, A., Procopio), R., Cuzzucrea, Giussano (D., Gentile), G., Margonato, Milano San Raffaele (A., Bassanelli), G., Tavazzi, Pavia San Matteo (L., Buzzi, M. P., Rordorf), R., Gualco, Pavia Fondazione Salvatore Maugeri (A., Opasich), C., Gronda, Rozzano (E., Genovese), L., Mattioli, Sesto San Giovanni (R., Donatelli), F., Salerno Uriarte), Varese (J. A., Rauhe), P. A. Bolzano: Bolzano (W., Bertagnolli, P. A. Trento: Cles (C., Canestrini), S., Stefenelli, Trento Villa Bianca (C., Cioffi), G., Disertori, Trento Santa Chiara (M., Zeni, P., Giovanelli), C., Rigatelli, Veneto: Bovolone (G., Boni, S., Pasini), A., Sitta), Conegliano Santa Maria dei Battuti (N., Sacchetta, Conegliano Veneto De Gironcoli (A., Borgese, L., Sciascia), R., Targa), Este (L., Raviele, Mestre (A., Madalosso), M., Bertaglia, Mirano (E., Zoppo), F. C., Capanna, Porto Viro (M., Fiorencis), R., Baracca), Rovigo (E., Rossi, San Bonifacio (R., Carbonieri, E., Rossi), I., Trappolin), Villafranca di Verona (R., Morgera, Friuli Venezia Giulia: Monfalcone (T., Barducci), E., Baldin, Palmanova (M. G., Gobbo), G., Zardo, Pordenone (F., Hrovatin), E., Mos, San Daniele del Friuli (L., Vriz), O., Sinagra, Trieste Az. Ospedaliera-Universitaria Ospedali Riuniti (G., Aleksova), A., Scardi, Trieste Az. Servizi Sanitari n. 1 Triestina (S., Mazzone), C., Fresco), Udine (C., Rubartelli, Liguria: Genova-Sampierdarena (P., Moroni), L. A., Camerieri), Genova-Voltri (A., Piana), Imperia (M., Mureddu), Pietra Ligure (R., Bertoli, Sarzana-Loc. S. Caterina (D., Petacchi), R., Pancaldi, Emilia Romagna: Bentivoglio (L. G., Gabrieli), L., Urbinati, Bologna Bellaria (S., Pedone), C., Di Pasquale, Bologna Maggiore (G., Di Niro, M., Brunelli), A., Bosi, Cotignola (S., Censi), S., Pratola), Ferrara (C., Moruzzi, Fidenza (P., Pastori), P., Modena, Modena (M. G., Malavasi), V., Mezzetti), Rimini (M., Melandri), Sassuolo (F., Zuppiroli, Toscana: Bagno a Ripoli (A., Fazi), A., Testa, Cecina (R., Venturini, E., Mazzinghi), F., Cosmi, Cortona (F., Cosmi), D., Santoro, Firenze Nuovo Osp. S Giovanni di Dio (G. M., Minneci), C., Galli, Livorno (M., Paperini), L., Bovenzi, Lucca (F. M., Cortigiani), L., Cocchieri, Umbria: Città di Castello (M., Severini, D., Arcuri), G. M., Bagliani), Foligno (G., Bernardinangeli, Terni (M., Proietti, G., Proietti), G., Bocconcelli, Marche: Pesaro (P., Pierantozzi), A., Monti, Lazio: Albano Laziale (F., Giamundo), L., Tancredi, Formia (P., Rossini), E., Bianchi), Roma Centro Traumatologico Ortopedico (C., Roma San Camillo, Bettiol), Cardiologia Riabilitativa e Preventiva (F., Giovannini, Cardiologia I (E., Fera), M. S., Santini, Roma San Filippo Neri (M., Bianconi), L., Boccanelli, Roma San Giovanni (A., Morosetti), P., Volpe, Roma Sant'Andrea (M., Facciolo), C., Vacri, Abruzzo: Penne (A., Romanazzi), F., Napoletano, Teramo (C., Piccioni), L. L., Candelmo), Campania: Avellino (F., De Marco, Aversa (G., Arnese), M. R., Vetrano), Caserta (A., Prinzi, Giugliano in Campania (D., De Rosa), P., Capuano, Mercato San Severino (V., Torre), S., D'Onofrio, Napoli Azienda Ospedaliera Monaldi (A., Ammendola), E., Chiariello, Napoli Policlinico Universitario Federico II (M., Perrone Filardi), P., Battista, Piedimonte Matese (R., De Fusco), A., Molero), Pozzuoli (U., Iervoglini, San Felice a Cancello (A., Stefanelli), S., Fattore, Santa Maria Capua Vetere (L., Bosco), B., Liguori, Vallo della Lucania (A., Padula), G., De Luca, Puglia: Bari Ospedale Consorziale Policlinico (I., Sorino, M., Colonna), P., D'Agostino, Bari-Carbonara (C., Pierfelice), O., Pettinati, Casarano (G., Muscella), A., De Lorenzi, Scorrano (E., Falco), M., Giannattasio), Taranto Villa Verde (C., Baldi), Taranto Santissima Annunziata (N., Clemente), Basilicata: Matera (M. A., D'Alessandro, Policoro (B., Truncellito), L., Arabia, Calabria: Catanzaro Pugliese (F., Ciconte), V. A., Perticone, Catanzaro Germaneto (F., Ruberto), C., Buffon, Cosenza Santissima Annunziata (A., Tomaselli), C., De Rosa, Cosenza Mariano Santo (F., Mazza), S., Zampaglione, Crotone (G., Pirozzi), A. M., Butera, Lamezia Terme (A., Levato), M., Musacchio), Paola (D., Polimeni, Polistena (R. M., Lacquaniti), V., Pulitanò, Reggio Calabria (G., Ruggeri), A., Provenzano), Rogliano (A., Cuccurullo), San Marco Argentano (O., Musolino, Scilla (M., Marrari), A., Anastasio, Soriano Calabro (L., Schiavello), M., Comito), Vibo Valentia (M. G. A., Gulizia, Sicilia: Catania (M. M., Francese), G. M., Vasquez, Milazzo (L., Coppolino), C., Casale, Nicosia (A., D'Urso), G., Oliva, Palermo Civico e Benfratelli (G., Giordano, U., Andolina), S., Sanfilippo, Palermo Villa Sofia (N., Ingrillì), F., Accardo), Palermo Buccheri La Ferla (S., Grasso, Palermo Cervello (S., Buffa), L., and Sardegna: Cagliari Brotzu, (E. Serra).

Published
2009

42. Health Technology Assessment Report on Lucentis

Author

Ricciardi, W., La Torre, G., Gualano, MARIA ROSARIA, Nicolotti, N., de Waure, C., Mannocci, A., Specchia, Ml, Capizzi, S., Cicchetti, A., Ruggeri, M., Sacchini, D., Fioravanti, L., Ponzianelli, A., Varano, M., Parravano, M., Bertocchi, F., and Perfumo, A.

Published
2008

44. Comparison of valsartan 160 mg with lisinopril 20 mg, given as monotherapy or in combination with a diuretic, for the treatment of hypertension: the Blood Pressure Reduction and Tolerability of Valsartan in Comparison with Lisinopril (PREVAIL) study

Author

Malacco, E, Santonastaso, M, Varì, Na, Gargiulo, A, Spagnuolo, V, Bertocchi, F, Palatini, P, Prevail Study Investigators, and Nami, Renato

Subjects
Adult, Male, medicine.medical_specialty, valsartan, lisinopril, hypertension, cough, side effects, Urology, Tetrazoles, Blood Pressure, Pharmacology, Placebo, Hydrochlorothiazide, Double-Blind Method, cough, Lisinopril, Medicine, hypertension, lisinopril, side effects, valsartan, Humans, Pharmacology (medical), Diuretics, Antihypertensive Agents, Aged, Chi-Square Distribution, business.industry, Valine, Middle Aged, Angiotensin II, Blood pressure, Treatment Outcome, Tolerability, Valsartan, Italy, ACE inhibitor, Hypertension, Drug Therapy, Combination, Female, business, circulatory and respiratory physiology, medicine.drug
Abstract

Background: The goal of antihypertensive therapy is to provide good blood pressure (BP) control without eliciting adverse effects. Objective: This study compared the risk-benefit profile of the angiotensin II receptor blocker valsartan with that of the angiotensin-converting enzyme inhibitor lisinopril in patients with mild to severe hypertension. The primary objective was to show that the equipotent BP-lowering effect of the valsartan-based treatment is accompanied by a better tolerability profile. Methods: This 16-week, randomized, double-blind, parallel-group study was conducted at 88 outpatient centers across Italy. After a 2-week placebo run-in period, patients aged ≥ 18 years with mild to severe hypertension (systolic BP [SBP], 160–220 mm Hg; diastolic BP [DBP], 95–110 mm Hg) were eligible. Patients were randomized to receive once-daily, oral, self-administered treatment with valsartan 160-mg capsules or lisinopril 20-mg capsules under double-blind conditions for 4 weeks. Responders continued monotherapy, whereas nonresponders had hydrochlorothiazide 12.5 mg added for the final 12 weeks of the study. The 2 primary variables used to assess the equivalence of therapeutic efficacy of the 2 regimens were sitting SBP and sitting DBP, which were measured at weeks 0 (baseline), 4, 8, and 16. The rate of drug-related adverse events (AEs) was used to assess whether 1 treatment had a better tolerability profile than the other. Tolerability was assessed by collecting information about AEs by means of questioning the patient or physical examination at each visit. Results: A total of 1213 patients were enrolled (635 men, 578 women; mean [SD] age, 54.5 [10.1] years [range, 28–78 years]). The study was completed by 1100 patients (553 receiving valsartan and 547 receiving lisinopril). Fifty-one patients (8.4%) treated with valsartan and 62 (1.2%) treated with lisinopril withdrew, mainly because of AEs (9 [1.5%] and 23 patients [3.8%], respectively). The valsartan- and lisinopril-based treatments were similarly effective in reducing sitting BP, with mean SBP/DBP reductions of 31.2/15.9 mm Hg and 31.4/15.9 mm Hg, respectively. At the end of the study, BP was controlled in 82.7% of the patients receiving valsartan and 81.6% of those receiving lisinopril. AEs were experienced by 5.1% of the patients treated with valsartan and 10.7% of those treated with lisinopril ( P = 0.001), with dry cough observed in 1.0% and 7.2% of patients, respectively ( P Conclusions: Valsartan and lisinopril were both highly effective in controlling BP in these patients with mild to severe hypertension, but valsartan was associated with a significantly reduced risk for AEs, especially cough.

Published
2004

48. Comparison of benazepril-amlodipine and captopril-thiazide combinations in the management of mild-to-moderate hypertension

Author

Malacco, E., Piazza, S., Carretta, R., DI SOMMA, Salvatore, Mugellini, A., Bertocchi, F., Palatini, P., and Pressure, I. B.

Subjects
combination, Male, calcium channel blockers, administration /&/ dosage/adverse effects/therapeutic use, Captopril, essential hypertension, Administration, Oral, Benzazepines, Middle Aged, ace inhibitors, administration, aged, amlodipine, antihypertensive agents, benzazepines, captopril, combination therapy, double-blind method, drug administration schedule, drug therapy, female, humans, hydrochlorothiazide, hypertension, male, middle aged, oral, Drug Administration Schedule, Hydrochlorothiazide, Double-Blind Method, Hypertension, Humans, Drug Therapy, Combination, Female, Amlodipine, Antihypertensive Agents, Aged
Abstract

To compare the efficacy and tolerability of benazepril 10 mg + amlodipine 5 mg combination (BZ+AM) versus captopril 50 mg + hydrochlorothiazide 25 mg (CP+HT) combination.405 outpatients with mild-to-moderate arterial hypertension not adequately controlled by a monotherapy with ACE inhibitors or calcium channel blockers or diuretics entered this multicenter, double-blind, randomized, parallel-group study.After a 2-week placebo run-in, 397 patients with sitting diastolic (D) blood pressure (BP)95 mmHg and/or sitting systolic (S) BP160 mmHg were randomized to receive either BZ+AM (201 patients) or CP+HT (196 patients) once daily for 12 weeks. Main outcome measure was sitting DBP and SBP values at the end of active treatment. The response rate was defined as the proportion of patients with either a final sitting DBP90 mmHg or decreased by at least 10 mmHg or a sitting SBP150 mmHg or decreased by at least 20 mmHg from baseline.The DBP and SBP values obtained with BZ+AM were, respectively, 2.7 and 3.7 mmHg lower than those obtained with CP+HT (both p0.001 vs. CP+HT). The response rate in the BZ+AM group (94.8%) was better than that observed in the CP+HT group (86.0%, p = 0.004). The incidence of adverse events was similar with the 2 treatment regimens (17.9% for both).These data suggest a higher antihypertensive efficacy of the fixed combination BZ 10 mg+AM 5 mg as compared with CP 50 mg+HT 25 mg.

Published
2002

50. 'Through:peak ratio and smootness index in the evaluation of 24-h blood pressure control in hypertension: a comparative study between valsartan/hydrochlorothiazide combination and amlodipine.P. Palatini, E. Malacco, S. Di Somma, R. Carretta, F. Dorigatti, F. Bertocchi, J. Mann.Eur. J. Clin. Pharm. 57:765-70; 2002 (1.955)

Author

Palatini, P., Malacco, E., DI SOMMA, S., Carretta, Renzo, Dorigatti, F., Bertocchi, F., J. M. A. N. N., E. U. R. J. C. L. I. N. PHARM, P., Palatini, E., Malacco, S., DI SOMMA, Carretta, Renzo, F., Dorigatti, F., Bertocchi, and J. M. A. N. N., E. U. R. J. C. L. I. N. PHARM

Published
2002

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