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Experimental studies have demonstrated the effects of maternal fructose consumption during pregnancy and lactation on metabolic alterations in their offspring, especially male offspring. However, few studies have focused on female offspring after providing fructose in food to dam rats. Here, we studied whether offspring of both sexes were differentially affected by a maternal high-fructose diet (HFD). For this purpose, Sprague-Dawley rats were fed during pregnancy and lactation with a standard diet (SD) or a HFD (50% w/w). After weaning, offspring were fed an SD; 3 days later, dams were sacrificed, and their offspring were sacrificed on postnatal day 90. Body weight (BW), food and water intake (only for dams), and various biomarkers of metabolic syndrome were measured. When compared to the SD-fed dams, HFD-fed dams had a reduction in BW and food and water intake. Conversely, adiposity, liver weight, liver lipids, and plasma levels of glucose, insulin, cholesterol, triglycerides, and uric acid were increased in HFD-fed dams. Moreover, the BW, food consumption, weight of retroperitoneal fat pads, and liver lipids increased in female and male offspring of HFD-fed dams. Interestingly, the pups of HFD-fed mothers showed increased levels of leptin and insulin resistance and decreased levels of adiponectin which were more pronounced in male offspring than in female offspring. In contrast, a higher increase in BW was shown earlier in female offspring. Thus, high-fructose consumption by dams during pregnancy and lactation led to sex-specific developmental programming of the metabolic syndrome phenotype in adult offspring. [ABSTRACT FROM AUTHOR]

Fresh green chilli, in Mexico, are of importance not only because they are part of the food diet, but because of the workforce that generates their production; however, the soils of the producing states have alkaline pH and this causes iron fixation (Fe), which is a vital element in the quality of the fruits. Therefore, the objective of the study was to determine the effect of an iron fulvate (FFe), on the quality of ‘serrano’ chili fruits for which increasing doses of a mixture of fulvic acids and ferrous sulfate (FFe) were used to 200, 400, 600, 800, 1 000 and 1 200 mg kg-1 added four times to the soil: at the time of transplantation, at 15, 45 and 60 ddt and a nutritive solution (SN) as a control. The performance and quality variables measured to the fruit: fresh weight (PFF), dry weight (PSF), length (LF), diameter (DF), firmness (FI), total soluble solids (SST) and iron (Fe) and calcium (Ca), to the plant tissue of foliage. With the high dose of 1 200 mg kg-1 the highest value of PFF, LF and DF was obtained, while with the dose of 1 000 mg kg-1 the highest value of PSF was obtained, FI obtained the highest value high with the dose of 400 mg kg-1 and with the lowest dose of the organic-mineral complex the highest values of SST and NF were obtained. With respect to the concentration of nutrients in foliar tissue the dose of 1000 mg kg-1 caused optimal Fe values and close to the optimum of Ca, while with the lowest doses of 200 and 400 mg kg-1 the concentration of both minerals was in excess. [ABSTRACT FROM AUTHOR]

Introduction: There are no data on the association of type of pneumonia and long-term mortality by the type of pneumonia (COVID-19 or community-acquired pneumonia [CAP]) on long-term mortality after an adjustment for potential confounding variables. We aimed to assess the type of pneumonia and risk factors for long-term mortality in patients who were hospitalized in conventional ward and later discharged., Methods: Retrospective analysis of two prospective and multicentre cohorts of hospitalized patients with COVID-19 and CAP. The main outcome under study was 1-year mortality in hospitalized patients in conventional ward and later discharged. We adjusted a Bayesian logistic regression model to assess associations between the type of pneumonia and 1-year mortality controlling for confounders., Results: The study included a total of 1,693 and 2,374 discharged patients in the COVID-19 and CAP cohorts, respectively. Of these, 1,525 (90.1%) and 2,249 (95%) patients underwent analysis. Until 1-year follow-up, 69 (4.5%) and 148 (6.6%) patients from the COVID-19 and CAP cohorts, respectively, died ( p  = 0.008). However, the Bayesian model showed a low probability of effect (PE) of finding relevant differences in long-term mortality between CAP and COVID-19 (odds ratio 1.127, 95% credibility interval 0.862-1.591; PE = 0.774)., Conclusion: COVID-19 and CAP have similar long-term mortality after adjusting for potential confounders., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Méndez, González-Jiménez, Latorre, Mengot, Zalacain, Ruiz, Serrano, España, Uranga, Cillóniz, Hervás, Torres, Menéndez, NEUMONAC and RECOVID.)