1. An Effect of Pyridine-2-Aldoxime Methiodide (2-PAM) on Cholinesterase at Motor End-Plates
- Author
-
Wagley Pf and Bergner Ad
- Subjects
chemistry.chemical_classification ,Pralidoxime Compounds ,integumentary system ,biology ,Chemistry ,Motor end plates ,Dual effect ,Oxime ,Motor Endplate ,Medicinal chemistry ,Muscular Dystrophies ,General Biochemistry, Genetics and Molecular Biology ,In vitro ,Pyridine-2-aldoxime methiodide ,chemistry.chemical_compound ,Enzyme ,stomatognathic system ,Picolines ,embryonic structures ,parasitic diseases ,biology.protein ,Cholinesterases ,Humans ,reproductive and urinary physiology ,Cholinesterase - Abstract
Conclusion2-PAM in a high concentration in vitro had a dual effect on motor end-plate ChE previously inactivated with TEPP. The oxime reactivated the enzyme and, if allowed to remain in contact with the preparation, inhibited the reactivated enzyme. The effect of 2-PAM was reversible and after the removal of 2-PAM no protection to ChE from the later exposure to TEPP was demonstrated.
- Published
- 1958
- Full Text
- View/download PDF