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We aimed to describe the medical management, clinical profil and therapeutic characteristics as well as the activity of Rheumatoid Arthritis in women from Western Algeria. For this reason, We performed a retrospective analytical study based on medical records over 257 women in Western Algeria (North Africa) diagnosed with rheumatoid arthritis at the level of internal medicine and rehabilitation departments of Sidi bel Abbes University Hospital. SPSS 22.0 software was used to calculate the various statistical tests presented in this survey. the mean age of diagnosis (Mean±SD) was 52.584±12.3013, ranging from 14 to 80 years old. 73.2% of patients were from urban area. Concerning medical histories 40.1% of patients had high blood pressure and type 2 diabetes (15.2%),the hand joints were the most affected in our study, Disease Activity Index 28 (DAS 28) between 3.2 and 5 was noted in more than half of our population, followed by high activity, Rheumatoid factors and Anti-CCP (anti-Cyclic Citrullinated Peptides) was positive in 43.97% and 43.58% of patients with a DAS 28 between 3.2(p<0.0001).Further prospective studies with a larger number of patients are needed to better understand the different acts of this disease. [ABSTRACT FROM AUTHOR]

Background and aims: To assess the compliance to the gluten-free diet (GFD) of Algerian patients with celiac disease (CD) and to study the impact of long-term GFD on anthropometric, serological, and histological parameters of these patients. Material and method: We conducted a retrospective study on 111 cases of CD patients followed up, from pediatric age until now, at the pediatrics department of the ORAN University Hospital Centre for many years. Two groups were made according to their adherence to the gluten-free diet. Results: The clinical presentation of the disease was typical (84.7%) and atypical (15.3%). Two groups were selected group A and B for non-compliant diets (39.6%) and compliant diets (60.4%), respectively. There was a significant difference between the current age and the two groups of adherence (p=0.008) and with body mass index (BMI) (p<10-3). However, we noticed an excellent significant difference between a serology under diet and two groups (p=0.001) also with the grade of histology (p<10-3). Moreover, a significant reduction of IgA and IgG anti-t-TG in group B (p=0.001). Conclusions: CD in Algeria is still characterized by heterogeneous clinical symptoms and good compliance to the GFD is a sign of the path to recovery. [ABSTRACT FROM AUTHOR]

Background: This study aimed to demonstrate the gender and age-at-onset differences in rheumatoid arthritis (RA) in the western Algerian population and their impacts on patients' clinical features and medical management. Methods: A retrospective cross-sectional study was carried out at the Internal Medicine and Functional Rehabilitation Departments (University Hospital of Sidi-bel-Abbes region) based on medical records of over 306 RA patients diagnosed between 2016 and 2019 according to ACR 1987 criteria. Late-onset RA (LORA) was defined as disease onset at 51 years of age or older. All data were processed and analyzed via SPSS 22.0. Results:We enrolled 306 rheumatoid arthritis patients (85% women) with a mean age-at-onset of 52.47±12.14. Algerian RA women were more at risk of developing type 2 diabetes (P = 0.035), hypertension (P = 0.003), and thyroid disorders (P = 0.05). We did not find any significant relationship between clinical features, laboratory data, and gender. The LORA group comprised 60.5% of our study population with a higher number of comorbidities such as hypertension (P < 0.001), osteoporosis (P = 0.007), and scleroderma (P = 0.014). Nonetheless, we found evidence of an association between positive anti-CCP, RF rate, and age-at-onset (P = 0.001 and P < 0.001, respectively). Conclusions: Algerian RA women with LORA presented a higher prevalence of comorbidities, while Young-onset RA (YORA) was associated with a high rate of RF. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to demonstrate the relationships between anti-citrullinated peptide/protein antibodies status and clinical characteristics, disease severity, radiological damages and laboratory assessment in Algerian patients with Rheumatoid arthritis, as well as their importance like a predictive factor for the diagnosis of Rheumatoid arthritis (RA). Methods: 281 patients diagnosed with RA according to ACR 1987 criteria in the internal medicine and Functional Rehabilitation departments (the University Hospital of Sidi Bel Abbes) were enrolled in the study based on medical records including age, gender, disease duration, disease activity score (DAS28), joint damages, laboratory tests and treatment. All data were processed and analyzed via SPSS 22.0. Results: 86.5% of patients were females with a mean age and disease duration of respectively 52.665±12.3477, 4.19±4.050. Patients with Anti- CCP positive (79.7%) presented a high disease activity (p<0.0001), a long disease duration (p=0.016) and a erosion damages (p<0.0001). we did not found any significant relation between gender, hands damages and CRP..A logistic regression showed that the presence of Anti-CCP was associated with Erosion, disease activity, age and RF presence. Conclusion: There was a strong relation between Anti-CCP antibodies status and the development of RA in Algerian patients. It could be considered as a useful predictor of disease severity. [ABSTRACT FROM AUTHOR]