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3. Evaluation of Serum Magnesium Levels in Patients with the Diagnosis of Depressive Disorder Applied to a Psychiatry Clinic: A Retrospective Study.

Author

ALTUNÖZ, Sinan, BAYKAN, Hayriye, and BAYKAN, Özgür

Subjects
DIAGNOSIS of mental depression, REFERENCE values, PEARSON correlation (Statistics), MAGNESIUM, PSYCHIATRIC treatment, OUTPATIENT services in hospitals, ACADEMIC medical centers, CREATININE, T-test (Statistics), DATA analysis, SEX distribution, RETROSPECTIVE studies, AGE distribution, DESCRIPTIVE statistics, MANN Whitney U Test, CHI-squared test, BLOOD sugar, GAMMA-glutamyltransferase, STATISTICS, HYPOMAGNESEMIA, DATA analysis software
Abstract

Copyright of Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi is the property of Balikesir Health Sciences Journal (BAUN Health Sci J) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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5. CORRELATION AMONG EXPERIENTIAL AVOIDANCE, ANXIETY SENSITIVITY AND BEHAVIORAL INHIBITION SYSTEM IN GENERALIZED ANXIETY DISORDER AND PANIC DISORDER PATIENTS

Author

Akdeniz Görgülü, Serap, Baykan, Hayriye, Karlıdere, Tunay, Akdeniz Görgülü, Serap, Baykan, Hayriye, and Karlıdere, Tunay

Abstract

Purpose: This study aimed to analyze the concepts of experiential avoidance, anxiety sensitivity and behavioral inhibition system through healthy volunteers and patients diagnosed with anxiety disorder. It was planned to analyze and evaluate the correlation among the levels of experiential avoidance, anxiety sensitivity and behavioral inhibition system in various anxiety groups. Method: Within the scope of this study, clinical interviews were carried out with patients who sought treatment at the Psychiatry Department of the Hospital of Balıkesir University Medical Faculty. The study included 50 Generalized Anxiety Disorder (GAD) patients and 50 Panic Disorder (PD) patients who fulfilled the study criteria and accepted to participate in the study. A voluntary control group of 50 individuals with similar age and gender with the patients was formed. The participants were evaluated through the Acceptance and Action Questionnaire-II (AAQ-II), Behavioral Inhibition System/Behavioral Approach System Scale (BIS/BAS Scale), and Anxiety Sensitivity Index-3 (ASI-3). Results: In this study, the anxiety sensitivity, behavioral inhibition system sensitivity and experiential avoidance levels were all found to be higher in both the GAD and PD patients than the controls. On the other hand, the scale scores did not significantly differ between the GAD patients and PD patients. Positive correlations were determined among anxiety sensitivity, experiential avoidance and behavioral inhibition system. Our data provided findings supporting that the development of anxiety disorders entails increased anxiety sensitivity, behavioral inhibition system sensitivity and experiential avoidance levels. Discussion: The literature has shown, through separate studies, a correlation among experiential avoidance, anxiety sensitivity and behavioral inhibition system as well as a correlation between these concepts and anxiety disorders, and this study handled them altogether to reveal their correlation wi

Published
2023

6. Relationship between Alexithymia and Coping Attitudes in Generalized Anxiety Disorder.

Author

Baykan, Hayriye and Can, Merve Şahin

Abstract

Among anxiety disorders, the incidence of alexithymic features is found in a wide range of 12.5-58%, and it is a personality trait that can also be seen in healthy individuals. Our study investigated the relationship between alexithymic features and coping attitudes in patients with generalized anxiety disorder. Forty patients diagnosed with Generalized Anxiety Disorder and 39 healthy volunteers participated in the study. Participants were divided into groups using the Toronto Alexithymia Scale, and the Hamilton Anxiety Scale and Coping Attitudes Scale were applied to all participants. Nineteen patients with alexithymia and Generalized anxiety disorder, 21 patients with Generalized anxiety disorder without alexithymia, and 39 healthy volunteers participated in this study. Statistically significant differences were observed between the problem-focused coping and emotion-focused coping subscale scores, but there was no difference in dysfunctional coping styles between the three groups. In the correlation analysis performed to determine the relationship between the total alexithymia and Coping attitudes subscale scores, there was a moderate negative correlation between the alexithymia scores and problem-focused (r=-0.442) and emotion-focused coping (r=-0.425) subscale scores. Alexithymia is often accompanied by generalized anxiety disorder and negatively affects coping attitudes. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Dysfunctional Metacognitive Beliefs, Experiential Avoidance,and Behavioral Inhibition System in Depressive Disorder.

Author

Baykan, Hayriye and Can, Merve Şahin

Abstract

Background: Dysfunctional metacognitive beliefs form the basis of the formation and maintenance of psychopathologies. In our study, we planned to examine the common aspects of the concepts of dysfunctional metacognition, experiential avoidance, and behavioral inhibition system in depressed patients compared to healthy individuals and their effects on each other. Methods: Fifty-five depressed patients and as a control group 54 healthy volunteers participated in the study. Beck Depression Inventory, Beck Anxiety Inventory, Metacognitions Questionnaire 30, Acceptance and Action Questionnaire II, and Behavioral Inhibition and Behavioral Activation Scale were used in the study. Results: Median (minimum--maximum) Acceptance and Action Questionnaire II score was 9 (7-35) points in the control group and 30 (9-46) points in the depressed patient group (P < .001). A statistically significant difference between the groups was observed only in the Behavioral Activation Scale--reward responsiveness subscale, with 20 (14-30) points in the control group and 23 (13-36) points in the patient group. A statistically significant difference was observed between the groups in all Metacognitions Questionnaire 30 subscale scores (P < .001). A statistically significant positive correlation was found between depression scores and experiential avoidance (r = 0.751; P < .001), reward responsiveness (r = 0.329; P < .001) and metacognition subscale scores. In addition, a positive correlation was found between experiential avoidance and metacognition subscale scores (P < .001). Conclusion: The data we obtained support the fact that as the severity of depression increases, the patients more strongly stick to dysfunctional metacognitive beliefs, exert more frequently experiential avoidance and less often impulsive behaviors. Considering these clinical features may contribute favorably to the individualized psychotherapy process. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Yaygın anksiyete bozukluğu tanılı bireylerde plazma nöropeptid-s düzeyleri: Bir kontrollü çalışma

Author

Baykan, Hayriye, Baykan, Özgür, Durmaz, Onur, Kara, Hayrettin, Hişmioğulları, Adnan Adil, Karlıdere, Tunay, and Tıp Fakültesi

Subjects
Inflammation, Generalized Anxiety, Neuropeptide-S, HPA, GAD
Abstract

Baykan, Hayriye (Balikesir Author), Introduction: Neuropeptide S (NPS) is a novel neuropeptide reported to be involved in fear- and stress-related conditions and their corresponding neuroendocrine processes. The aim of this study was to compare the plasma NPS levels in patients suffering from generalized anxiety disorder (GAD) and those of healthy controls. Methods: A total of 40 subjects diagnosed with GAD and 40 healthy controls were recruited in the study. The Hamilton Anxiety Scale (HAM-A), Generalized Anxiety Disorder-7 (GAD-7), and Hamilton Depression Scale (HAM-D) were administered to all participants to determine the severity of participants' anxiety and concomitant depressive symptoms. The plasma NPS levels were measured from the fasting venous blood samples obtained from each participant. Results: The median plasma NPS level was found to be significantly higher in the GAD group in comparison to the control group (28.8 pg/mL as against 19.1 pg/mL, p=0.01). A significant positive correlation was observed between the plasma NPS levels and HAM-A scores (rs=0.23, p=0.04) as well as the GAD-7 scores (rs=0.28, p=0.01). The p-value obtained from the correlation analysis between the plasma NPS levels and HAM-D scores was 0.052. A receiver operating characteristic (ROC) analysis revealed that the plasma NPS levels could enable the identification of GAD with 67.5% sensitivity and 62.5% specificity, when the cut-off value was determined as 25.06 pg/mL. Conclusions: Our results support the view that plasma NPS levels, which has demonstrated anxiolytic effects on the central nervous system, is related to the severity of anxiety in GAD and could be considered as a candidate marker for the identification of GAD., Balikesir University Coordinatorship of Scientific Research Projects - 2014/71

Published
2019

17. Vitamin d levels and vitamin d receptor gene polymorphism in major depression

Author

Can, Merve Şahin, Baykan, Hayriye, Baykan, Özgür, Erensoy, Nevin, Karlıdere, Tunay, and Tıp Fakültesi

Subjects
Major Depressive Disorder (MDD), Vitamin D, VDR
Abstract

Baykan, Hayriye (Balikesir Author), "Background: The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polymorphism of vitamin D in patients with established diagnosis of major depressive disorder in order to investigate the impact of vitamin D levels and genetic polymorphisms on etiology and/or severity of the disease. Subjects and methods: The study included 86 patients who were diagnosed with major depressive disorder in Hospital of Balikesir University Faculty of Medicine, Department of Psychiatry, and 89 healthy volunteers with similar age, sex, education level and BMI. Psychiatric diagnosis was established by using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). For clinical evaluation, sociodemographic data form, Hamilton Depression Rating Scale, Hamilton Anxiety Scale were used. Blood samples were drawn after 12 hours of fasting from the patients volunteered and the control group who were given their informed consent for participation in the study. Vitamin D levels were determined by using the method of ECLIA (Electrochemiluminescent immunoassay). Genotype analysis was performed using the method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: In our study, median vitamin D levels (min-max) of the patient and control groups were 10.3 ng/mL (3.0-42.1) and 11.4 ng/mL (3.0-38.8), respectively. Statistically significant differences as for vitamin D levels between groups were not detected (p=0.729). Similiarly no statistically significant difference between groups in genotype distribution was observed (p=0.396). Conclusion: In conclusion, our findings do not support the relationship between depression, vitamin D levels and Fok 1 polymorphism of vitamin D receptor. To test these hypotheses in the light of literature we need further studies to be performed with large number of patients.", Balikesir University, Scientific Research Project

Published
2017

22. Zihinsel Engelli Çocukların Annelerinde Depresyon,Anksiyete ve Stresle Başa Çıkma Tutumları

Author

ŞENGÜL, Sevgi and BAYKAN, Hayriye

Subjects
Handicapped children, mother, depression, stres coping strategies
Abstract

Objective: This study is planned in order to assess the depression, anxiety and stres coping strategies of the mothers whose children are mentally-disabled Material and Methods: 50 patients among the mothers of mentally-disabled children and 50 controls among the mothers of healthy children, were involved in the study. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) was used to assess current psychiatric disorders. Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-D) were applied. Besides, Stress Coping Strategies Scale (COPE) was applied in order to assess the patients’ strategies of coping with problems. Results: The median score (minumum-maximum) which they got from Hamilton Depression Rating Scale is 6 which is evaluated statistically-significant compared to the score of the control group of which score is 4.5 . The median score which the patients got from Hamilton Anxiety Rating Scale is 7.0 which is evaluated statisticallysignificant compared to the score of control group of which score is 5.0 . It is found out that the patients involved in the study use denial and behavioral ignorance more than the control group when they are assessed according to their strategies of coping with problems. Conclusion: Families are mostly inadequate in the process of coping with this dense, stressful and long-term problem and they have some different behavioral and emotional problems. Therefore, it is important to support the families, especially the mothers who give primary care to the child, Amaç: Bu çalışma, zihinsel engelli çocuğu olan annelerin depresyon, değerlendirmek amacıyla yapılmıştır. anksiyete Gereç ve Yöntem: Çalışmaya zihinsel engelli çocuk anneleri arasından 50 ve kontrol olarak sağlıklı çocuk annesi 50 kişi alınmıştır. Tüm katılımcılarla psikiyatrik görüşme yapılmış, ilk görüşmede DSM-IV Eksen-I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) kullanılarak katılımcılarda psikiyatrik bozukluk varlığı araştırmacılar tarafından değerlendirilmiştir. Her katılımcıya Hamilton Depresyon Derecelendirme Ölçeği (HAM-D) ve Hamilton Anksiyete Değerlendirme Ölçeği (HAM-D) uygulanmıştır. Ayrıca katılımcılara sorunla başa çıkma tutumlarını değerlendirmek için Başa Çıkma Tutumları Ölçeği (COPE) yapılmıştır. Bulgular: Zihinsel engelli çocuk annelerinin Hamilton Depresyon Derecelendirme Ölçeği’nden aldıkları puanların ortancası (en düşük-en yüksek) 6.0 , kontrol grubunun ise (en düşük- en büyük) 4.5 olup aradaki fark istatistiksel olarak anlamlı bulunmuştur (p

Published
2015

23. Plasma Neuropeptide-S Levels in Populations Diagnosed with Generalized Anxiety Disorder: A Controlled Study.

Author

BAYKAN, Hayriye, KARLIDERE, Tunay, BAYKAN, Özgür, DURMAZ, Onur, KARA, Hayrettin, and HIŞMIOĞULLARI, Adnan Adil

Subjects
*DIAGNOSIS of mental depression, *GENERALIZED anxiety disorder, *CENTRAL nervous system, *COMPARATIVE studies, *FASTING, *NEUROPEPTIDES, *PROBABILITY theory, *PSYCHOLOGICAL tests, *DISABILITIES, *RECEIVER operating characteristic curves, *DIAGNOSIS
Abstract

Introduction: Neuropeptide S (NPS) is a novel neuropeptide reported to be involved in fear-and stress-related conditions and their corresponding neuroendocrine processes. The aim of this study was to compare the plasma NPS levels in patients suffering from generalized anxiety disorder (GAD) and those of healthy controls. Methods: A total of 40 subjects diagnosed with GAD and 40 healthy controls were recruited in the study. The Hamilton Anxiety Scale (HAM-A), Generalized Anxiety Disorder-7 (GAD-7), and Hamilton Depression Scale (HAM-D) were administered to all participants to determine the severity of participants' anxiety and concomitant depressive symptoms. The plasma NPS levels were measured from the fasting venous blood samples obtained from each participant. Results: The median plasma NPS level was found to be significantly higher in the GAD group in comparison to the control group (28.8 pg/mL as against 19.1 pg/mL, p=0.01). A significant positive correlation was observed between the plasma NPS levels and HAM-A scores (rs=0.23, p=0.04) as well as the GAD-7 scores (rs=0.28, p=0.01). The p-value obtained from the correlation analysis between the plasma NPS levels and HAM-D scores was 0.052. A receiver operating characteristic (ROC) analysis revealed that the plasma NPS levels could enable the identification of GAD with 67.5% sensitivity and 62.5% specificity, when the cut-off value was determined as 25.06 pg/mL. Conclusions: Our results support the view that plasma NPS levels, which has demonstrated anxiolytic effects on the central nervous system, is related to the severity of anxiety in GAD and could be considered as a candidate marker for the identification of GAD. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Alprazolam induced anxiety

Author

Baykan, Hayriye, Kul, Müslüm, and Ümraniye Eğitim ve Araştırma Hastanesi

Subjects
Alprazolam, Paradoksik Etki, Anksiyete
Abstract

Anksiyete bozuklukları toplumda en yaygın görülen, sosyal, mesleki ya da diğer günlük işlevlerde kayıplara yol açan ruhsal bozukluklardır. Anksiyete semptomlarının azaltılması amacıyla yaygın olarak kullanılan benzodiazepinlerden biri alprazolamdır. Yazımızda paradoksik bir şekilde alprazolam tedavisi ile anksiyete artışı ortaya çıkan bir olgu sunulmuştur. Anxiety disorders are the most prevalent mental disorders in the general population. Anxiety cause impairment in social, occupational or other daily functioning. Alprazolam decreases anxiety symptoms and is widely used for this indication. In this paper, it is reported a case that exhibits anxiety paradoxically with alprozolam.

Published
2013

25. Alprazolam kullanımına bağlı anksiyete artışı

Author

BAYKAN, Hayriye and KUL, Müslüm

Subjects
Anksiyete, alprazolam, paradoksik etki, Psikoloji, Anxiety, paradoxical reaction
Abstract

Anxiety disorders are the most prevalent mental disorders in the general population. Anxiety cause impairment in social, occupational or other daily functioning. Alprazolam decreases anxiety symptoms and is widely used for this indication. In this paper, it is reported a case that exhibits anxiety paradoxically with alprozolam, Anksiyete bozuklukları toplumda en yaygın görülen, sosyal, mesleki ya da diğer günlük işlevlerde kayıplara yol açan ruhsal bozukluklardır. Anksiyete semptomlarının azaltılması amacıyla yaygın olarak kullanılan benzodiazepinlerden biri alprazolamdır. Yazımızda paradoksik bir şekilde alprazolam tedavisi ile anksiyete artışı ortaya çıkan bir olgu sunulmuştur

Published
2013

26. Epilepsi ayırıcı tanısında psikojenik non-epileptik nöbetler

Author

Çakıl, Duygu, İnanır, Sema, Baykan, Hayriye, Aygün, Hatice, Kozan, Ramazan, Gaziosmanpaşa Üniversitesi, and 0-Belirlenecek

Subjects
Nörolojik Bilimler, Klinik Nöroloji
Abstract

Epilepsi; çocukluk ve ergenlik çağında en sık, erişkinlerde ise serebrovasküler hastalıklarından sonra ikinci sıklıkta görülen nörolojik bir hastalıktır. Bu yaygın prevalansına rağmen, özellikle psikojenik nöbetlerden ayırt etme noktasında epilepsinin kesin tanısının konulması sırasında çeşitli zorluklarla karşılaşılmaktadır. Psikojenik non-epileptik nöbetler (PNES), en sık karşılaşılan ve epileptik nöbetlerden ayırt edilmesi en zor durumlardan biridir. Özellikle, üçüncü basamak sağlık kurumlarındaki epilepsi birimlerine farmakolojik tedaviye dirençli nöbet tanısıyla başvuran hastaların % 17-30’unu bu hasta grubu oluşturmaktadır. Doğru tanı konmadığında PNES hastaları, doğru tedavinin gecikmesi, uzun süre antiepileptik ilaçların maddi yükü ve yan etki olasılıkları gibi ciddi ve çok yönlü sıkıntılarla karşı karşıya kalmaktadır. Bu hem hastalar için hem de konuyla ilgili bütün sağlık birimleri çalışanları için hem iş gücü, zaman ve ekonomik kayba hem de psikolojik etkilenmeye neden olmaktadır. Bundan dolayı, bu makalede epileptik ve non-epileptik nöbetlerin genel özellikleri sunularak bu iki nöbetin ayırıcı tanısında kullanılabilecek elektrofizyolojik, biyokimyasal ve psikolojik test yöntemleri güncel literatür ışığında tartışılmıştır. Epilepsy is the most common neurological disorder in adoles- cence and also the second common disease after the cerebro- vascular problems in adults. In spite of its high prevalance; there are lots of difficulties on definitive diagnosis of epilepsy; especially on differential diagnosis with psychogenic seizures. Psychogenic non epileptic seizures (PNES) are one of the most common and the most difficult diseases to differentially diag- nose from epileptic seizures. Particularly; 17-30 % of patients consulted epilepsy units in tertiary health institutions with complaint of seizures resistant to pharmacological therapy, are in this group. When the PNES patients are misdiagnosed; they are exposed to serious and versatile problems such as detention of the correct treatment, financial burden and pos- sible side effects of antiepileptic drugs. This problems cause psychological effects and also loss of labor, time and money in both patients and sanitarians. Therefore; in this paper, we int- roduced general properties of epileptic and non epileptic sei- zures and also discussed the electrophysiologic, biochemical and psychologic analyse methods for the differential diagnosis of these diseases by evaluating actual literature.

Published
2013

27. Depression, anxiety, stress coping strategies of the mothers of mentally-disabled children

Author

Şengül, Sevgi, Baykan, Hayriye, Ağrı Devlet Hastanesi, and Ümraniye Eğitim ve Araştırma Hastanesi

Subjects
Depresyon, Engelli Çocuk, Stresle Başa Çıkma, Anne
Abstract

Amaç: Bu çalışma, zihinsel engelli çocuğu olan annelerin depresyon, anksiyete ve başa çıkma tutumlarını değerlendirmek amacıyla yapılmıştır. Gereç ve Yöntem: Çalışmaya zihinsel engelli çocuk anneleri arasından 50 ve kontrol olarak sağlıklı çocuk annesi 50 kişi alınmıştır. Tüm katılımcılarla psikiyatrik görüşme yapılmış, ilk görüşmede DSM-IV Eksen-I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) kullanılarak katılımcılarda psikiyatrik bozukluk varlığı araştırmacılar tarafından değerlendirilmiştir. Her katılımcıya Hamilton Depresyon Derecelendirme Ölçeği (HAM-D) ve Hamilton Anksiyete Değerlendirme Ölçeği (HAM-D) uygulanmıştır. Ayrıca katılımcılara sorunla başa çıkma tutumlarını değerlendirmek için Başa Çıkma Tutumları Ölçeği (COPE) yapılmıştır. Bulgular: Zihinsel engelli çocuk annelerinin Hamilton Depresyon Derecelendirme Ölçeği’nden aldıkları puanların ortancası (en düşük-en yüksek) 6.0 (1-23), kontrol grubunun ise (en düşük- en büyük) 4.5 (0-19) olup aradaki fark istatistiksel olarak anlamlı bulunmuştur (p

Published
2013

29. Hemodiyaliz ve sürekli ayaktan periton diyalizi hastalarında depresyon ve anksiyete bozuklukları, yaşam kaliteleri, cinsel hayatları ve stresle başa çıkma tutumları

Author

Baykan, Hayriye, Yargıç, Lütfi İlhan, and Psikiyatri Ana Bilim Dalı

Subjects
Psychiatry, Psikiyatri
Abstract

Bu araştırmanın amacı hemodiyaliz ve sürekli ayaktan periton diyalizi (SAPD) tedavisi uygulanan kronik böbrek hastaları ve kontrol grubu hastalarını depresyon ve anksiyete bozuklukları, yaşam kaliteleri, cinsel hayatları ve stresle başa çıkma tutumları açısından değerlendirmektir. Çalışmamızın örneklemi İstanbul Üniversitesi, İstanbul Tıp Fakültesi Hastanesi, İstanbul Eğitim ve Araştırma Hastanesi ve 2 özel diyaliz merkezinde tedavi gören hemodiyaliz(n=42) ve SAPD(n=41) hastalarından oluşmaktadır. Bununla birlikte hasta gruplarıyla benzer sosyodemografik özellikler gösteren 41 sağlıklı kişide çalışmaya alındı. Hastalarda psikiyatrik bozukluk varlığını belirlemek amacıyla ilk görüşmede DSM-IV Eksen-I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) uygulandı. Ayrıca Hastane Anksiyete ve Depreyon Ölçeği (HADS), Kısa form-36, Stresle Başa Çıkma Tutumları Ölçeği(COPE), Arizona Cinsel Yaşantılar Ölçeği(ACYÖ) ve sosyodemografik veri formları uygulandı. Çalışmamızda; SCID-I'e göre diyaliz hastalarının %59,5'i, SAPD hastalarının %53,7'i ve kontrol grubunun %26,8'ine psikiyatrik bozukluk tanısı konuldu. Her üç grupta da en sık depresif bozukluklar görüldü. Her ne kadar en sık hemodiyaliz hasta grubunda görülse de depresif bozukluklar, cinsel işlev bozuklukları ve anksiyete bozuklukları açısından hemodiyaliz ve SAPD grupları arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. Stresle başa çıkmada hemodiyaliz hastaları SAPD hastalarına göre istatistiksel açıdan anlamlı olarak daha fazla işlevsel olmayan başa çıkma tutumlarını kullanmaktadırlar. Yaşam kalitelerine bakıldığında ise SAPD hastalarının fiziksel komponent puanları hemodiyaliz hastalarının fiziksel komponent skorlarından istatistiksel olarak anlamlı derecede yüksektir. Ruhsal komponent skorlarıda SAPD hasta grubunda yüksek olmakla birlikte aralarındaki fark istatistiksel olarak anlamlı değildir. Sonuç olarak hastaların psikiyatrik açıdan değerlendirilmesi psikiyatrik morbiditenin azaltılması ve yaşam kalitesinin arttırılması için oldukça önemlidir. The aim of this study is to evaluate depression, anxiety disorders, quality of life, sexual life and coping strategies with stress in chronic renal disease patients treated with hemodialysis, continuous ambulatory peritoneal dialysis(CAPD) and healthy control groups . The study sample was composed of patients who were undergoing hemodialysis (n=42) and CAPD (n=41) in Istanbul University, Istanbul Faculty of Medicine Hospital , Istanbul Education and Research Hospital and two private dialysis center. However, 41 healthy person having similar sociodemographic properties with the patient groups were chosen. Firstly we identified psychiatric disorders by using a structured clinical interview for DSM-IV Axis I Diagnosis (SCID-I). Additionally, Hospital Anxiety and Depression Scale (HADS), Short Form-36, Coping Strategies with Stress Inventory, Arizona Sexuel Experiences Scale(ASEX) and Questionnaire for Sociodemographic Information were applied. In this study; according to SCID-I; 59,5% of dialysis patients, 53,7% of CAPD patients and % 26,8 of controls were diagnosed with a psychiatric disorder. The most common disorder was depressiv disorders all of the groups. Although this disorders were mostly seen in hemodialysis patients, there was no statistically significant difference between hemodialysis and CAPD groups in depressive disorders, sexual disfunction and anxiety disorders. According to ASEX; 78,6% of hemodiyalysis and 65,9% of CAPD patients have sexual function disorders. The disfunctional coping strategies that used by hemodialysis patients were significantly higher than CAPD patients. As we assessed the quality of life, physical component scores of CAPD patients were significantly higher than the score of hemodialysis patients. Psychological component scores of CAPD patients were also higher than hemodialysis patients but the difference between the two groups were not statistically significant. Finally, we suggest that psychiatric assesment of these patients is essential to diminish pscyhiciatric morbidity and to enhance of quality of life. 100

Published
2010

34. Quality of life in children and adolescents with chronic kidney disease: a comparative study between different disease stages and treatment modalities.

Author

Kul, Müslüm, Çengel-Kültür, S. Ebru, Şenses-Dinç, Gülser, Bilginer, Yelda, Uluç, Sait, and Baykan, Hayriye

Abstract

This study aimed to compare the quality of life of children and adolescents in various stages of their chronic kidney disease (CKD) who were managed with different treatment modalities to that of children and adolescents without any chronic disease. The study included 18 renal transplant and 21 dialysis patients (8 on hemodialysis, 13 on peritoneal dialysis) and 16 patients who did not yet require renal replacement therapy. The control group consisted of 37 children without any chronic disease. Psychosocial Health Summary scores, Physical Health Summary scores, and Total Scale scores of Pediatric Quality of Life Inventory scores were estimated for the groups. CKD patients had lower scores in all scales of Pediatric Quality of Life Inventory than the control group. There were no differences in self-reported scores on the Pediatric Quality of Life scale scores between treatment groups; however, parents of the transplant patients had reported higher (more favorable) Physical Health Summary scores than those of the dialysis patients. Reports of parents and their children differed only in Physical Health Summary scores in the dialysis group; self-reports of the children were more favorable. These findings show that children and adolescents with CKD experience impaired quality of life on the physical and psychosocial functioning domains in comparison with healthy controls. The study findings implicate the need for further studies to investigate the quality of life in CKD patients at different stages as well as the perceptional differences between pediatric and adolescent CKD patients and caregiver proxy-reports about their quality of life. [ABSTRACT FROM AUTHOR]

Published
2013

35. Ağır psikiyatrik bozukluklar, depresyon ve sigara bırakma.

Author

YARGIÇ, L. İlhan and BAYKAN, Hayriye

Subjects
*SMOKING cessation, *PATHOLOGICAL psychology, *NICOTINE, *SCHIZOPHRENIA, *BIPOLAR disorder
Abstract

In recent years, large campaigns have been organized for smoking cessation, health professionals have been educated about this topic and special treatment programs have been developed by the government for smokers. Although cigarette smoking is very frequent among patients with severe mental illness and it's a cause of morbidity and mortality, psychiatrists are not very eager for smoking cessation among psychiatric patients. However, in recent years, treatment studies have shown that with some modifications, conventional smoking cessation approaches may be quite beneficial among these severe mentally ill patients who are classically known to be failures in such treatments. In recent years, there have been developments in pharmacological approaches for smoking cessation, but neuropsychiatric side effects of these medications may be serious. Risk and benefit ratio for each patient should be taken into account while making a treatment plan. [ABSTRACT FROM AUTHOR]

Published
2013
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36. Relationship between obesity and anxiety with nesfatin-1.

Author

Baykan, Hayriye, Baykan, Ozgur, Oguz, Elif Gulsah, Kara, Hayrettin, Gorgulu, Serap Akdeniz, Yaman, Ali, and Karlidere, Tunay

Subjects
*OBESITY, *PUBLIC health, *ETHYLENEDIAMINETETRAACETIC acid, *AMINO acids, *AMINO compounds
Abstract

Objective: Obesity is an important public health problem that is rapidly growing in the world. Obesity is a disease that causes multi-organ damage and death if not treated. Therefore, there are many research projects related to obesity. The relationship between obesity and the nesfatin 1 molecule was described for the first time in 2006. This 82-amino-acid molecule is related to satiety and is located in the hypothalamus. These molecules are secreted from neurons in areas where energy balance is regulated in the brain. This secretion suggests that the molecule can play a protective role against the development of obesity. However, in recent years, plasma levels of nesfatin in patients who develop obesity and psychiatric disorders are reported to be different from those in the healthy population. In our study, we aimed to detect levels of plasma nesfatin of highly anxious patients, low-anxious patients and non-obese healthy individuals and compare their results. Methods: Blood samples were collected into tubes containing EDTA (Becton Dickinson, USA). Centrifugation at 1300g is used to separate the plasma. The plasma was divided into Eppendorf tubes and then 1% concentration protease inhibitor cocktail (Sigma Aldrich, USA) was added. It was then stored at -20°C. Analysis was performed using the ELISA method with a commercial kit (RayBiotech, USA). SPSS 15.0 software was used for statistical analysis. Statistical significance level P <0.05 was adopted. After psychiatric interviews with patients, Hospital Anxiety and Depression (HAD) scale was applied and anxiety scores were evaluated. Results: The study involved totally 83 participants in 3 groups; obese-anxious (Group1) (n=29), obese-non-anxious (Group2) (n=29) and nonobese-nonanxious (Group3) (n=25). There was no statistically significant difference between the groups in terms of age and sex structure. The nesfatin-1 levels of Group1, Group2 and Group3 were 28.4±7.1, 28.7±6.9 and 34.6±10.9, respectively. In terms of nesfatin-1 levels, there were statistically significant differences between Group3 and both Group1 (p=0.023) and Group2 (p=0.034). Conclusion: In our study, the measured nesfatin-1 levels of obese patients were found significantly lower compared with healthy controls independently of anxiety scores. There are many different data about nesfatin-1 in the literature, so we need further researches about this subject. [ABSTRACT FROM AUTHOR]

Published
2015

37. Can plasma nesfatin-1 level predict major depressive disorder?

Author

Baykan, Hayriye, Baykan, Ozgur, Ustunsoy, Seyfettin, Aydin, Duygu, and Yargic, Ilhan

Subjects
*NEUROPEPTIDES, *MENTAL depression, *RECEIVER operating characteristic curves
Abstract

Objective: After the development of molecular biology, many neuropeptides have been identified and described. A recently discovered neuropeptid Nesfatin-1, derived from the nucleobindin 2 (NUCB2) precursor, consists of 82 amino acids. Oh firstly described that intracerebroventricular injection of NUCB2 reduces feeding in a dose dependent manner in rats. With regard to anorectic properties, recent studies showed that plasma concentration of nesfatin- 1 is associated with major depression. Method: Sixty five patients diagnosed with MDD (Major Depressive Disorder) according to DSM-IV and healthy volunteers (n=19) with matching BMI, age, and sex were included in the study. Plasma nesfatin-1 levels were measured using a commercial ELISA kit (USCN Life Science, PRC). Statistical analysis was performed using MedCalc 11.6.0.0 software. Comparisons between groups were made using Mann- Whitney U test. The capacity of plasma Nesfatin-1 level in predicting presence of major depression disorder was analyzed using ROC (Receiver Operating Characteristics) curve analysis. The p values less then 0.05 were considered statistically significant. Results: The mean±SD Nesfatin-1 levels were 2.15±0.53 ng/mL and 1.75±0.23 ng/mL in patients and control groups, respectively. Differences between groups were statistically significant (p<0.001). ROC curve analysis showed statistically significant associations between Nesfatin-1 levels and MDD. Optimizing the sensitivity and specificity of the nesfatin-1 levels using ROC analysis provided a cutoff point of 2.0 ng/mL, which corresponded to 47.7% of sensitivity and 94.7% of specificity. Conclusion: We suggest that Nesfatin-1 levels might be a useful biological tool for screening the MDD. [ABSTRACT FROM AUTHOR]

Published
2013

38. Major depresif bozukluk hastalarında metakognitif işlevlerin somatik semptomlar ile ilişkisi

Author

Çakir, Seyyid Ömer, Baykan, Hayriye, and Ruh Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Psychiatry, Psikiyatri
Abstract

AMAÇ: Somatik semptomlar major depresif bozukluk hastalarının ciddi bir kısmına eşlik etmektedir. Bireyin yaşam kalitesini, tedaviye yanıtını bozmakta ve relaps ihtimalini arttırmaktadır. Bu çalışmanın amacı major depresif bozukluk hastalarında metakognitif inançlar ve bilinçli farkındalığın somatik semptomlar ile ilişkisini araştırmaktır.YÖNTEM VE GEREÇLER: Çalışmamızın katılımcıları, Balıkesir Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri Polikliniği'ne başvuran ve major depresif bozukluk tanısı alan (n=100) hastalar ve hasta grubuyla benzer yaşa, cinsiyete ve eğitim düzeyine sahip olan (n=96) gönüllülerden oluşmaktadır. Hastaların tanıları alanında uzman kişilerce yarı yapılandırılmış görüşme sonucunda koyulmuştur. Değerlendirme için her iki gruptaki katılımcılar Sosyodemografik Veri Formu, Üstbiliş Ölçeği-30, Bradford Bedensel Belirti Envanteri, Hastane Anksiyete ve Depresyon Ölçeği ve Bilinçli Farkındalık Ölçeği ile değerlendirilmiştir.SONUÇLAR: Çalışmamızda hasta gruplarının Üstbiliş-30 ölçeği ortanca değerleri kontrol grubundan fazla, Bilinçli Farkındalık Ölçeği ortanca değerleri ise düşük saptanmıştır, yani gruplar arasında istatistiksel olarak anlamlı fark saptanmıştır. Major depresif bozukluk hastalarında Bradford Bedensel Belirti Envanteri skorları ile Bilinçli Farkındalık Ölçeği skoru arasında istatistiksel olarak anlamlı negatif korelasyon saptanmıştır. Bradford Bedensel Belirti Envanteri skorları ile Üstbiliş Ölçeği-30'un düşünceleri kontrol edilemez ve tehlikeli olarak değerlendiren alt boyutunun skorları arasında ise istatistiksel olarak anlamlı pozitif korelasyon saptanmıştır.TARTIŞMA: Bulgularımız somatik semptomlar ile bilinçli farkındalık ve olumsuz metakognitif inançlar arasındaki ilişkiyi desteklemektedir. Bilinçli farkındalık ve metakognitif inançların somatik semptomların gelişimindeki rolünü aydınlatmak için literatürdeki bilgiler ışığında bilişsel süreçlerin başka basamaklarını test eden daha kapsamlı çalışmalara ihtiyaç vardır. AIM: Somatic symptoms accompany a significant proportion of patients with major depressive disorder, impair the quality of life, response to treatment, and increase the likelihood of relapse. The aim of this study is to investigate the relationship between metacognitive beliefs and mindful awareness and somatic symptoms in patients with major depressive disorder.METHODS: The study sample was composed of patients who were diagnosed with major depressive disorder (n = 100) in Balıkesir University Faculty of Medicine Hospital, Department of Psychiatry. Having similar age, sex and education level with patients healthy volunteers (n=96) were included in the study as control group. The diagnoses of the patients were made by a semi-structured interview by experts in the field. We applied sociodemographic data form prepared by the researchers. Hospital Anxiety and Depression Scale, The Metacognitions Questionnaire-30, The Bradford Somatic Inventory, The Mindful Attention Awareness Scale were used for clinical assesment.RESULTS: In our study, the median values of The Metacognitions Questionnaire-30 scores were found to be higher than the control group and the median values of The Mindfulness Attention Awareness Scale were lower, meaning a statistically significant difference between the groups. There was a statistically significant negative correlation between Bradford Somatic Inventory scores and The Mindful Attention Awareness Scale in patients with major depressive disorder. A statistically significant positive correlation was found between the Bradford Somatic Inventory scores and the scores of the The Metacognitions Questionnaire-30 subscale which was considered uncontrollable and dangerous.CONCLUSION: Our findings support the relationship between somatic symptoms and mindful awareness and negative metacognitive beliefs. To test the hypothesis we need further studies with large number of patients. 80

Published
2019

39. Yaygın anksiyete bozukluğu ve panik bozukluk hastalarında yaşantısal kaçınma, anksiyete duyarlılığı ve davranışsal inhibisyon sistemi arasındaki ilişki

Author

Akdeniz Görgülü, Serap, Baykan, Hayriye, and Ruh Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Psychiatry, Panic disorder, Sensitivity, Psychopathology, Inhibition (Psychology), Experiential avoidance, Anxiety, Psikiyatri, Anxiety disorders, Inhibition
Abstract

AMAÇ: Güncel araştırmalar anksiyete ile ilişkili psikopatolojilerin gelişiminde kişilik boyutları ve özdenetim mekanizmaları arasındaki etkileşimin etkisine dair kanıtlar üzerinde durmaktadır. Çalışmamızın amacı Yaygın Anksiyete Bozukluğu ve Panik Bozukluk hastalarında yaşantısal kaçınma, anksiyete duyarlılığı ve davranışsal inhibisyon sistemi arasındaki ilişkiyi değerlendirmektir. YÖNTEM: Çalışmamızın örneklemi, Balıkesir Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri Polikliniği'ne başvurarak Yaygın Anksiyete Bozukluğu (YAB) tanısı alan (n=50) ve Panik Bozukluk (PB) tanısı alan (n=50) hastalardan oluşmaktadır. Hasta gruplarıyla benzer yaş ve cinsiyete sahip olan (n=50) gönüllüler kontrol grubu olarak çalışmaya alınmıştır. Hastalarda psikiyatrik tanı varlığı DSM-IV Eksen I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) uygulanarak koyulduktan sonra, YAB ve PB tanısı alanlar Ruhsal Bozuklukların Tanısal ve İstatistiksel El Kitabının beşinci baskısı (DSM V) ile doğrulanmıştır. Anksiyete bozukluklarının doğası gereği eşlik eden depresyonun sık görülebileceği göz önünde bulundurularak YAB ve PB hastalarında eşlik eden depresyonu olanlar da çalışmaya alınmıştır. DSM V'e göre yeni eklenen tanılar ayrıca dışlanmıştır. Hastalığın şiddetini değerlendirmek amacıyla Yaygın Anksiyete Bozukluğu tanısı alan hastalara Yaygın Anksiyete Bozukluğu-7 Maddeli Ölçeği (YAB-7), Panik Bozukluk tanısı alan hastalara Panik Agorofobi Ölçeği (PAÖ) uygulanmıştır. Tüm katılımcılar Hamilton Depresyon Değerlendirme Ölçeği (HDDÖ), Hamilton Anksiyete Değerlendirme Ölçeği (HADÖ), Kabullenme ve Eylem Formu II (KEF-II), Davranışsal İnhibisyon Sistemi / Davranışsal Aktivasyon Sistemi Ölçeği (DİS/DAS Ölçeği), Anksiyete Duyarlılığı İndeksi-3 (ADİ-3) ile değerlendirilmiştir. SONUÇLAR: Çalışmamızda hasta gruplarının (YAB ve PB) ortalama ADI-3, DİS ve KEF-II puanları sağlıklı kontrollere göre yüksek saptanmıştır. Tüm gruplarda ADI-3, DİS ve KEF-II arasında korelasyon olduğu saptanmıştır. TARTIŞMA: Sonuç olarak bulgularımız yaşantısal kaçınma, anksiyete duyarlılığı ve kişilik boyutları arasındaki ilişkiyi desteklemektedir. Literatürdeki bilgilerin ışığında bu bağlantıların test edilmesi için daha geniş vaka sayılarıyla yapılacak çalışmalara ihtiyaç vardır. Anahtar kelimer: Yaygın anksiyete bozukluğu, Panik bozukluk, Yaşantısal kaçınma, Anksiyete duyarlılığı, Davranışsal inhibisyon sistemi. AIM: Recent studies have underlined the evidences about the effects of interaction between personality dimensions and self-regulatory mechanisms on development of anxiety-related psychopathology. The aim of this study was to assess the association between experiential avoidance, anxiety sensitivity and behavioral inhibition system in generalized anxiety disorder and panic disorder patients. METHOD: The study sample was composed of patients who were diagnosed with Generalized Anxiety Disorder (GAD) (n = 50) and Panic Disorder (PD) (n=50) in Balıkesir University Faculty of Medicine Hospital, Department of Psychiatry. Having similar age and sex with patient groups healthy volunteers (n=50) were included in the study as control group. After using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) for the diagnosis, YAB and PB diagnosis were confirmed with DSM V. Patients who had depression accompany to YAB and PB were included due to anxiety disorders nature that depression usually exist with anxiety disorders. New diagnosis added with DSM V were also excluded. In order to assess the severity of diseases Generalized Anxiety Disorder patients took Generalized Anxiety Disorder-7 (GAD-7) scale, Panic Disorder patients took Panic and Agoraphobia Scale (PAS). All participants were assessed via Hamilton Depression and Hamilton Anxiety Rating Scales, Acceptance and Action Questionnaire-II (AAQ-II), Behavioral Inhibition System/ Behavioral Approach System Scale (BIS/BAS Scale), Anxiety Sensitivity Index-3 (ASI-3). RESULTS: In our study, mean scores of AAQ-II, BİS and ASI-3 were greater in patient groups than healthy controls. In all groups correlations between AAQ-II, BİS and ASI-3 were detected. CONCLUSION: In conclusion, our findings support the relationship between experiential avoidance, anxiety sensitivity and personality dimensions. To test the connections we need further studies with large number of patients. Key words: Generalized Anxiety Disorder, Panic Disorder, experiential avoidance, anxiety sensitivity, behavioral inhibition system 87

Published
2018

40. Major depresyonda d vitamini düzeyleri ve d vitamini reseptör gen polimorfizmi

Author

Şahin Can, Merve, Baykan, Hayriye, and Ruh Sağlığı ve Hastalıkları Anabilim Dalı

Subjects
Psychiatry, Psikiyatri
Abstract

AMAÇ: Bu araştırmanın amacı; major depresif bozukluk tanısı alan hastalarda D vitamini düzeyleri ve D vitamini reseptöründeki genetik polimorfizmlerden biri olan rs2228570 (FokI) polimorfizmini değerlendirilmesi, vitamin düzeyleri ile genetik polimorfizmin uyku, dürtüsellik, somatik yakınmalar ve hastalık şiddeti üzerindeki etkisinin araştırılmasıdır. YÖNTEM VE GEREÇLER: Çalışmamızın örneklemi, Balıkesir Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri Polikliniği'ne başvuran ve major depresif bozukluk tanısı alan (n=86) hastalardan oluşmaktadır. Bununla birlikte, hasta grubuyla benzer yaş ve cinsiyete sahip olan (n=89) gönüllüler çalışmaya alınmıştır. Hastalarda psikiyatrik tanı varlığı DSM-IV Eksen I Bozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I) uygulanarak koyulduktan sonra, klinik değerlendirme için araştırmacı tarafından hazırlanan Sosyodemografik Veri Formu, Hamilton Depresyon Ölçeği, Hamilton Anksiyete Ölçeği, Pittsburgh Uyku Kalitesi Ölçeği, Barrats Dürtüsellik Ölçeği ve SCL 90 –R Somatik Yakınmalar Alt Ölçeği kullanılmıştır. Çalışmaya katılmayı kabul edip bilgilendirilmiş onamı alınan hastalardan ve sağlıklı gönüllülerden 12 saat açlık sonrası toplam 3 adet EDTA'lı tüpe kan alınmıştır. D vitamini düzeyleri ticari kitler aracılığıyla, ECLIA (Electro-chemiluminescence immunoassay ) yöntemi kullanılarak belirlenmiştir. Genotip tayini, Polimeraz Zincir Reaksiyonu-Restriksiyon Fragmanı Uzunluk Polimorfizmi (PCR-RFLP) analizi ile saptanmıştırSONUÇLAR: Çalışmamızda D vitamini düzeyleri ortanca (min-maks) değerleri hasta ve kontrol gruplarında sırasıyla 10.3 ng/mL (3.0- 42.1) ve 11.4 ng/mL (3.0- 38.8) olarak gözlenmiştir. D vitamini düzeyleri açısından gruplar arası istatistiksel olarak anlamlı fark tespit edilememiştir(p=0,729). FokI polimorfizmi genotip dağılımı açısından da hasta ve kontrol grupları arasında istatistiksel olarak anlamlı fark gözlenmemiştir (p=0.396). TARTIŞMA: Sonuç olarak bulgularımız depresyon ve D vitamini düzeyleri ve reseptördeki polimorfizm arasındaki ilişkiyi desteklememektedir. Literatürdeki bilgilerin ışığında bu hipotezlerin test edilmesi için daha geniş vaka sayılarıyla yapılacak çalışmalara ihtiyaç vardır. AIM: The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polimorhism, one of the genetic polymorphisms in the vitamin D receptor, in major depressive disorder patients and to investigate the impact of vitamin levels and genetic polymorphisms on quality of sleep, impulsivity, somatic symptoms and disease severity.METHODS: The study sample was composed of patients who were diagnosed with major depressive disorder (n = 86) in Balıkesir University Faculty of Medicine Hospital, Department of Psychiatry. Having similar age and sex with patients healthy volunteers (n=89) were included in the study as control group. After using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) for the diagnosis, we applied sociodemographic data form prepared by the researchers for clinical assessment, Hamilton Depression Rating Scale, the Hamilton Anxiety Scale, the Pittsburgh Sleep Quality Index, Barrats Impulsiveness Scale and SCL-90 somatic complaints subscales were used for clinical assesment. The patients and the control group were given informed consent and 12 hours fasting blood was taken. Vitamin D levels was determined using the method of ECLIA (Electrochemiluminescen immunoassay) through commercial kits. Genotype analysis was determined by the method Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).RESULTS: In our study, vitamin D levels median (min-max) values of the patient and control groups were 10.3 ng / mL (3.0- 42.1) and 11.4 ng / mL (3.0- 38.8), respectively. Statistically, significant differences for Vitamin D levels between groups were not detected (p = 0.729). Similiarly no statistically significant difference between groups in genotype distribution was observed (p = 0.396).CONCLUSION: In conclusion, our findings do not support the relationship between depression and vitamin D levels ande genetic polimorphism. To test the hypothesis we need further studies with large number of patients. 71

Published
2015

41. Assessment of neutrophil - Iymphocyte ratio in Alzheimer's disease and major depressive disorder patients.

Author

Can, Merve Sahin, Yilmaz, Elif Gulsah, Baykan, Ozgur, Baykan, Hayriye, and Karlidere, Tunay

Subjects
*NEUTROPHILS, *ALZHEIMER'S patients, *MENTAL depression
Abstract

Objective: The Blood Neutrophil-Lymphocyte Ratio (NLR) is an inexpensive and easily applicable method for the determination of inflammation. The recent studies often focused on the effect of inflammation in the etiology of neurological and psychiatric diseases. In a study investigating the role of inflammation in the pathogenesis of Alzheimer's Disease (AD), NLR had 69.3% sensitivity and 79.4% specificity for the prediction of AD with a cutoff value of 2.48. In another study, increased leukocyte count was showed in stress-related suicidal behavior and this was independent of the drugs. In this study, we aimed to evaluate if there is a relationship between inflammation and Major Depressive Disorder (MDD) and AD via NLR, also to assess if this relationship can be used in the differential diagnosis of retarded depression and AD in geriatric population. Method: In this study, we used retrospectively the blood test results of 21 retarded MDD patients and 26 AD patients over 55 age who attended in Balikesir University School of Medicine Department of Psychiatry Outpatient Clinic, between June 2012 and June 2013. The SPSS 15.0 statistical package program was used for statistical analyses of the data and statistical significance level of p<0.05 was considered. Results: In this study, NLR was 2.74±1.20 in patients with AD and 2.09±0.75 in patients with MDD and the difference between them was statistically significant (p= 0.03). Conclusion: According to this preliminary study, NLR may play a role as a biological indicator for distinguishing old age retarded MDD and AD patients. There are limited studies in this area and as far as we know this is the only one comparing AD and MDD patients. Therefore, it would be better to confirm those results with further studies of larger samples having control groups. [ABSTRACT FROM AUTHOR]

Published
2013

42. Effect of obesity on mood regulation and eating attitudes in mental disorders.

Author

Baykan H, Altunöz S, and Can MŞ

Subjects
Humans, Female, Adult, Male, Surveys and Questionnaires, Middle Aged, Mental Disorders psychology, Emotional Regulation physiology, Young Adult, Affect physiology, Obesity psychology, Body Mass Index, Feeding Behavior psychology, Feeding Behavior physiology
Abstract

Objective: The precise relationship between obesity and eating habits, attitudes, and emotion regulation is still ambiguous. The purpose of this study was to investigate possible correlations among body mass index, challenges related to managing emotions, and attitudes toward eating among adult participants with known psychiatric diagnoses., Methods: The body mass indices of participants were calculated, and data on eating styles were collected using the Dutch Eating Behavior Questionnaire. The level of difficulty in managing emotions was evaluated using the Difficulties in Emotion Regulation Scale., Results: The research findings indicated a meaningful positive association. An observation was made between body mass index and results from the Eating Attitude Test-40, as well as the restrained eating subdimension of the Dutch Eating Behavior Questionnaire. Conversely, a meaningful reverse relationship was identified between the scores of the "strategies" subdimension of the Difficulties in Emotion Regulation Scale. No meaningful differences in eating attitudes and emotion regulation were found between non-obese and obese patients., Conclusion: While a partial and meaningful correlation was observed among body mass index, eating attitudes, and emotion regulation difficulties, it is suggested that factors such as patients' age, disease duration, current body mass index, and the simultaneous presence of depression and anxiety should be considered.

Published
2024
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43. CORRELATION AMONG EXPERIENTIAL AVOIDANCE, ANXIETY SENSITIVITY AND BEHAVIORAL INHIBITION SYSTEM IN GENERALIZED ANXIETY DISORDER AND PANIC DISORDER PATIENTS.

Author

Akdeniz Görgülü S, Baykan H, and Karlıdere T

Subjects
Humans, Anxiety, Anxiety Disorders diagnosis, Inhibition, Psychological, Surveys and Questionnaires, Panic Disorder
Abstract

Purpose: This study aimed to analyze the concepts of experiential avoidance, anxiety sensitivity and behavioral inhibition system through healthy volunteers and patients diagnosed with anxiety disorder. It was planned to analyze and evaluate the correlation among the levels of experiential avoidance, anxiety sensitivity and behavioral inhibition system in various anxiety groups., Method: Within the scope of this study, clinical interviews were carried out with patients who sought treatment at the Psychiatry Department of the Hospital of Balıkesir University Medical Faculty. The study included 50 Generalized Anxiety Disorder (GAD) patients and 50 Panic Disorder (PD) patients who fulfilled the study criteria and accepted to participate in the study. A voluntary control group of 50 individuals with similar age and gender with the patients was formed. The participants were evaluated through the Acceptance and Action Questionnaire-II (AAQ-II), Behavioral Inhibition System/Behavioral Approach System Scale (BIS/BAS Scale), and Anxiety Sensitivity Index-3 (ASI-3)., Results: In this study, the anxiety sensitivity, behavioral inhibition system sensitivity and experiential avoidance levels were all found to be higher in both the GAD and PD patients than the controls. On the other hand, the scale scores did not significantly differ between the GAD patients and PD patients. Positive correlations were determined among anxiety sensitivity, experiential avoidance and behavioral inhibition system. Our data provided findings supporting that the development of anxiety disorders entails increased anxiety sensitivity, behavioral inhibition system sensitivity and experiential avoidance levels., Discussion: The literature has shown, through separate studies, a correlation among experiential avoidance, anxiety sensitivity and behavioral inhibition system as well as a correlation between these concepts and anxiety disorders, and this study handled them altogether to reveal their correlation with anxiety in a clinical environment.

Published
2023
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44. Vitamin D Levels and Vitamin D Receptor Gene Polymorphism in Major Depression.

Author

Can MŞ, Baykan H, Baykan Ö, Erensoy N, and Karlıdere T

Subjects
Adult, Depressive Disorder, Major blood, Depressive Disorder, Major diagnosis, Depressive Disorder, Major psychology, Female, Humans, Male, Middle Aged, Statistics as Topic, Turkey, Depressive Disorder, Major genetics, Genetic Predisposition to Disease genetics, Genotype, Polymorphism, Restriction Fragment Length genetics, Receptors, Calcitriol genetics, Vitamin D blood
Abstract

Background: The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polymorphism of vitamin D in patients with established diagnosis of major depressive disorder in order to investigate the impact of vitamin D levels and genetic polymorphisms on etiology and/or severity of the disease., Subjects and Methods: The study included 86 patients who were diagnosed with major depressive disorder in Hospital of Balıkesir University Faculty of Medicine, Department of Psychiatry, and 89 healthy volunteers with similar age, sex, education level and BMI. Psychiatric diagnosis was established by using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). For clinical evaluation, sociodemographic data form, Hamilton Depression Rating Scale, Hamilton Anxiety Scale were used. Blood samples were drawn after 12 hours of fasting from the patients volunteered and the control group who were given their informed consent for participation in the study. Vitamin D levels were determined by using the method of ECLIA (Electrochemiluminescent immunoassay). Genotype analysis was performed using the method of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP)., Results: In our study, median vitamin D levels (min-max) of the patient and control groups were 10.3 ng/mL (3.0-42.1) and 11.4 ng/mL (3.0-38.8), respectively. Statistically significant differences as for vitamin D levels between groups were not detected (p=0.729). Similiarly no statistically significant difference between groups in genotype distribution was observed (p=0.396)., Conclusion: In conclusion, our findings do not support the relationship between depression, vitamin D levels and Fok 1 polymorphism of vitamin D receptor. To test these hypotheses in the light of literature we need further studies to be performed with large number of patients.

Published
2017
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