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6. Hashimoto Thyroiditis

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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7. Chronic Thyroiditis

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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11. Goiter

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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12. De Quervain Thyroiditis

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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13. Basedow Disease

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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14. Thyroglossal Duct Cyst

Author

Basolo, Fulvio, Proietti, Agnese, Ugolini, Clara, van Krieken, J. H. J. M., Series Editor, La Rosa, Stefano, editor, and Uccella, Silvia, editor

Published
2022
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19. Thyroid Cysts

Author

Basolo, Fulvio, primary, Proietti, Agnese, additional, and Ugolini, Clara, additional

Published
2022
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22. Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules.

Author

Condello, Vincenzo, Poma, Anello M, Macerola, Elisabetta, Vignali, Paola, Paulsson, Johan O, Zedenius, Jan, Basolo, Fulvio, and Juhlin, C Christofer

Subjects
GENE expression, THYROID nodules, GENETIC mutation, IODINE isotopes, THYROID gland tumors, RAS oncogenes, MICRORNA
Abstract

Background Mutations in micro-RNA (miRNA) regulators DICER1 and DGCR8 have recently been uncovered, revealing a potential novel mechanism driving thyroid tumor development. However, the true frequency of these hotspot mutations in follicular-patterned thyroid tumors (FTs) and their relation to established driver gene events remain elusive. Methods A total of 440 FTs from 2 institutions were interrogated for DICER1, DGCR8, and RAS family hotspot mutations using Sanger sequencing. Whole-exome sequencing was also performed to identify additional driver gene aberrations in DICER1/DGCR8 -mutant cases. Subsets of cases were further analyzed using miRNA expression profiling, and key dysregulated miRNAs were validated as markers of DICER1 mutations using quantitative RT-PCR analysis. The Cancer Genome Atlas (TCGA) database was also probed for DICER1 / DGCR8 mutations and miRNA dysregulation. Results Fourteen (3.2%) and 4 (1%) FTs harbored DICER1 and DGCR8 hotspot mutations, respectively, in the combined cohort, and no cases with normal tissue available were found to exhibit a constitutional variant. Two DGCR8 -mutant cases also harbored oncogenic RAS mutations. Whole-exome sequencing analysis did not identify additional driver gene events in DICER1 / DGCR8- positive cases. Comprehensive miRNA expression profiling revealed a unique pattern of dysregulated miRNAs in DICER1 / DGCR8- mutant cases compared with wild-type lesions. Moreover, DICER1 -mutant cases showed a remarkable reduction of 5′ arm miRNAs, findings corroborated in the TCGA cohort. Conclusion DICER1 and DGCR8 hotspot mutations are rare in unselected cohorts of FTs, and mutated cases exhibit a specific miRNA profile. Although DGCR8 mutations may coexist with established RAS gene alterations, FTs with DICER1 variants were devoid of other driver gene events. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Role of Prophylactic Central Compartment Lymph Node Dissection on the Outcome Of Patients With Papillary Thyroid Carcinoma and Synchronous Ipsilateral Cervical Lymph Node Metastases

Author

De Napoli, Luigi, Matrone, Antonio, Favilla, Karin, Piaggi, Paolo, Galleri, David, Ambrosini, Carlo Enrico, Aghababyan, Alexander, Papini, Piermarco, Valerio, Laura, Viola, David, Torregrossa, Liborio, Ugolini, Clara, Proietti, Agnese, Basolo, Fulvio, Miccoli, Paolo, Elisei, Rossella, and Materazzi, Gabriele

Published
2020
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25. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors

Author

Nikiforov, Yuri E, Seethala, Raja R, Tallini, Giovanni, Baloch, Zubair W, Basolo, Fulvio, Thompson, Lester DR, Barletta, Justine A, Wenig, Bruce M, Al Ghuzlan, Abir, Kakudo, Kennichi, Giordano, Thomas J, Alves, Venancio A, Khanafshar, Elham, L., Sylvia, El-Naggar, Adel K, Gooding, William E, Hodak, Steven P, Lloyd, Ricardo V, Maytal, Guy, Mete, Ozgur, Nikiforova, Marina N, Nosé, Vania, Papotti, Mauro, Poller, David N, Sadow, Peter M, Tischler, Arthur S, Tuttle, R Michael, Wall, Kathryn B, LiVolsi, Virginia A, Randolph, Gregory W, and Ghossein, Ronald A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Patient Safety, Cancer, Clinical Research, Adenocarcinoma, Follicular, Adult, Aged, Aged, 80 and over, Carcinoma, Carcinoma, Papillary, Female, Humans, Male, Medical Overuse, Middle Aged, Neoplasm Invasiveness, Retrospective Studies, Terminology as Topic, Thyroid Cancer, Papillary, Thyroid Neoplasms, Thyroid Nodule, Young Adult, Public Health and Health Services, Oncology and carcinogenesis
Abstract

ImportanceAlthough growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer.ObjectiveTo evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological and clinical characteristics of EFVPTC.Design, setting, and participantsInternational, multidisciplinary, retrospective study of patients with thyroid nodules diagnosed as EFVPTC, including 109 patients with noninvasive EFVPTC observed for 10 to 26 years and 101 patients with invasive EFVPTC observed for 1 to 18 years. Review of digitized histologic slides collected at 13 sites in 5 countries by 24 thyroid pathologists from 7 countries. A series of teleconferences and a face-to-face conference were used to establish consensus diagnostic criteria and develop new nomenclature.Main outcomes and measuresFrequency of adverse outcomes, including death from disease, distant or locoregional metastases, and structural or biochemical recurrence, in patients with noninvasive and invasive EFVPTC diagnosed on the basis of a set of reproducible histopathologic criteria.ResultsConsensus diagnostic criteria for EFVPTC were developed by 24 thyroid pathologists. All of the 109 patients with noninvasive EFVPTC (67 treated with only lobectomy, none received radioactive iodine ablation) were alive with no evidence of disease at final follow-up (median [range], 13 [10-26] years). An adverse event was seen in 12 of 101 (12%) of the cases of invasive EFVPTC, including 5 patients developing distant metastases, 2 of whom died of disease. Based on the outcome information for noninvasive EFVPTC, the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was adopted. A simplified diagnostic nuclear scoring scheme was developed and validated, yielding a sensitivity of 98.6% (95% CI, 96.3%-99.4%), specificity of 90.1% (95% CI, 86.0%-93.1%), and overall classification accuracy of 94.3% (95% CI, 92.1%-96.0%) for NIFTP.Conclusions and relevanceThyroid tumors currently diagnosed as noninvasive EFVPTC have a very low risk of adverse outcome and should be termed NIFTP. This reclassification will affect a large population of patients worldwide and result in a significant reduction in psychological and clinical consequences associated with the diagnosis of cancer.

Published
2016

27. A pandemic recap: lessons we have learned

Author

Coccolini, Federico, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Viaggi, Bruno, Kuriyama, Akira, Picetti, Edoardo, Ball, Chad, Abu-Zidan, Fikri, Ceresoli, Marco, Turri, Bruno, Jain, Sumita, Palombo, Carlo, Guirao, Xavier, Rodrigues, Gabriel, Gachabayov, Mahir, Machado, Fernando, Eftychios, Lostoridis, Kanj, Souha S., Di Carlo, Isidoro, Di Saverio, Salomone, Khokha, Vladimir, Kirkpatrick, Andrew, Massalou, Damien, Forfori, Francesco, Corradi, Francesco, Delibegovic, Samir, Machain Vega, Gustavo M., Fantoni, Massimo, Demetriades, Demetrios, Kapoor, Garima, Kluger, Yoram, Ansari, Shamshul, Maier, Ron, Leppaniemi, Ari, Hardcastle, Timothy, Vereczkei, Andras, Karamagioli, Evika, Pikoulis, Emmanouil, Pistello, Mauro, Sakakushev, Boris E., Navsaria, Pradeep H., Galeiras, Rita, Yahya, Ali I., Osipov, Aleksei V., Dimitrov, Evgeni, Doklestić, Krstina, Pisano, Michele, Malacarne, Paolo, Carcoforo, Paolo, Sibilla, Maria Grazia, Kryvoruchko, Igor A., Bonavina, Luigi, Kim, Jae Il, Shelat, Vishal G., Czepiel, Jacek, Maseda, Emilio, Marwah, Sanjay, Chirica, Mircea, Biancofiore, Giandomenico, Podda, Mauro, Cobianchi, Lorenzo, Ansaloni, Luca, Fugazzola, Paola, Seretis, Charalampos, Gomez, Carlos Augusto, Tumietto, Fabio, Malbrain, Manu, Reichert, Martin, Augustin, Goran, Amato, Bruno, Puzziello, Alessandro, Hecker, Andreas, Gemignani, Angelo, Isik, Arda, Cucchetti, Alessandro, Nacoti, Mirco, Kopelman, Doron, Mesina, Cristian, Ghannam, Wagih, Ben-Ishay, Offir, Dhingra, Sameer, Coimbra, Raul, Moore, Ernest E., Cui, Yunfeng, Quiodettis, Martha A., Bala, Miklosh, Testini, Mario, Diaz, Jose, Girardis, Massimo, Biffl, Walter L., Hecker, Matthias, Sall, Ibrahima, Boggi, Ugo, Materazzi, Gabriele, Ghiadoni, Lorenzo, Matsumoto, Junichi, Zuidema, Wietse P., Ivatury, Rao, Enani, Mushira A., Litvin, Andrey, Al-Hasan, Majdi N., Demetrashvili, Zaza, Baraket, Oussama, Ordoñez, Carlos A., Negoi, Ionut, Kiguba, Ronald, Memish, Ziad A., Elmangory, Mutasim M., Tolonen, Matti, Das, Korey, Ribeiro, Julival, O’Connor, Donal B., Tan, Boun Kim, Van Goor, Harry, Baral, Suman, De Simone, Belinda, Corbella, Davide, Brambillasca, Pietro, Scaglione, Michelangelo, Basolo, Fulvio, De’Angelis, Nicola, Bendinelli, Cino, Weber, Dieter, Pagani, Leonardo, Monti, Cinzia, Baiocchi, Gianluca, Chiarugi, Massimo, Catena, Fausto, and Sartelli, Massimo

Published
2021
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32. Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.

Author

Poma, Anello M., Macerola, Elisabetta, Ghossein, Ronald A., Tallini, Giovanni, and Basolo, Fulvio

Subjects
THYROID cancer, THYROID gland tumors, TUMOR grading, TUMORS, PAPILLARY carcinoma, PUBLICATION bias
Abstract

Background: The current edition of the World Health Organization (WHO) classification of endocrine tumors introduced grading for follicular cell-derived thyroid cancer. Tumors with necrosis and/or high mitotic count but not fulfilling the Turin criteria for poorly differentiated carcinoma will be reclassified as differentiated high-grade thyroid carcinoma (DHGTC). However, the impact of this reclassification has not been evaluated. In this study, we performed a systematic review and meta-analysis to estimate the prevalence of this new entry across thyroid tumor subtypes. Methods: In this systematic review and meta-analysis, studies reporting data on necrosis and/or mitoses in well-differentiated thyroid carcinoma (WDTC) were used to estimate the prevalence of DHGTC. Heterogeneity and potential publication bias were also evaluated. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed, and quality assessment was performed using a modification of the Newcastle–Ottawa scale. The study has been registered in the International Prospective Register of Systematic Reviews (PROSPERO, ID: CRD42022378716). Results: In clinically unselected patients, the prevalence of DHGTC in WDTC was 0.072 [95% confidence interval, CI, = 0.045–0.113]. The proportion of high-grade tumors greatly varied across growth patterns and subtypes. Overall, the prevalence of DHGTC was higher in follicular thyroid carcinoma (FTC; 0.146 [CI = 0.101–0.205]) than in papillary thyroid carcinoma (PTC; 0.059 [CI = 0.036–0.097]). Diffuse sclerosing, follicular, and classic subtype PTC had the lowest rates of high-grade features (i.e., 0.018 [CI = 0.004–0.084]; 0.036 [CI = 0.010–0.124]; and 0.042 [CI = 0.027–0.066], respectively), while a greater proportion of solid trabecular and histologically aggressive PTC could be reclassified as DHGTC (i.e., 0.154 [CI = 0.067–0.314] and 0.168 [CI = 0.108–0.252], respectively). Similar proportions were obtained for minimally and widely invasive FTC (i.e., 0.136 [CI = 0.058–0.287] and 0.152 [CI = 0.086–0.254], respectively). Finally, in a cohort of patients with poor prognosis (i.e., fatal cases, metastatic and radioiodine resistant tumors, cases with biochemical recurrence), the proportion of DHGTC was 0.287 [CI = 0.155–0.469]. Conclusions: Following the current WHO indications, some tumors will be reclassified as DHGTC. The proportion of tumors with high-grade features is relevant in FTC, solid trabecular, and histologically aggressive PTC subtypes. A remarkable enrichment in DHGTC among patients with poor prognosis confirms the negative impact of high-grade features on outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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34. SARS-CoV-2 spread to endocrine organs is associated with obesity: an autopsy study of COVID-19 cases

Author

Poma, Anello Marcello, primary, Basolo, Alessio, additional, Alì, Greta, additional, Bonuccelli, Diana, additional, Di Stefano, Iosè, additional, Conti, Marco, additional, Mazzetti, Paola, additional, Sparavelli, Rebecca, additional, Vignali, Paola, additional, Macerola, Elisabetta, additional, Pistello, Mauro, additional, Santini, Ferruccio, additional, Basolo, Fulvio, additional, and Toniolo, Antonio, additional

Published
2023
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35. Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons

Author

Di Primio, Cristina, primary, Quaranta, Paola, additional, Mignanelli, Marianna, additional, Siano, Giacomo, additional, Bimbati, Matteo, additional, Scarlatti, Arianna, additional, Piazza, Carmen Rita, additional, Spezia, Piero Giorgio, additional, Perrera, Paola, additional, Basolo, Fulvio, additional, Poma, Anello Marcello, additional, Costa, Mario, additional, Pistello, Mauro, additional, and Cattaneo, Antonino, additional

Published
2023
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41. Cytological and Ultrasound Features of Thyroid Nodules Correlate With Histotypes and Variants of Thyroid Carcinoma

Author

Sgrò, Daniele, primary, Brancatella, Alessandro, additional, Greco, Giuseppe, additional, Torregrossa, Liborio, additional, Piaggi, Paolo, additional, Viola, Nicola, additional, Rago, Teresa, additional, Basolo, Fulvio, additional, Giannini, Riccardo, additional, Materazzi, Gabriele, additional, Elisei, Rossella, additional, Santini, Ferruccio, additional, and Latrofa, Francesco, additional

Published
2023
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42. SARS-CoV-2 infection leads to Tau pathological signature in neurons

Author

Di Primio, Cristina, primary, Quaranta, Paola, additional, Mignanelli, Marianna, additional, Siano, Giacomo, additional, Bimbati, Matteo, additional, Piazza, Carmen Rita, additional, Spezia, Piero Giorgio, additional, Perrera, Paola, additional, Basolo, Fulvio, additional, Poma, Anello Marcello, additional, Costa, Mario, additional, Pistello, Mauro, additional, and Cattaneo, Antonino, additional

Published
2023
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45. Outcomes of the Tall-Cell Variant of Papillary Thyroid Carcinoma in Patients with Different Ages: A 17-Year Mono-Institutional Experience

Author

Proietti, Agnese, primary, Signorini, Francesca, additional, Giannini, Riccardo, additional, Poma, Anello Marcello, additional, Macerola, Elisabetta, additional, Torregrossa, Liborio, additional, Materazzi, Gabriele, additional, Basolo, Alessio, additional, Santini, Ferruccio, additional, Elisei, Rossella, additional, Viola, David, additional, Basolo, Fulvio, additional, and Ugolini, Clara, additional

Published
2023
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46. Supplementary Figure 1 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Author

Salvatore, Giuliana, primary, Nappi, Tito Claudio, primary, Salerno, Paolo, primary, Jiang, Yuan, primary, Garbi, Corrado, primary, Ugolini, Clara, primary, Miccoli, Paolo, primary, Basolo, Fulvio, primary, Castellone, Maria Domenica, primary, Cirafici, Anna Maria, primary, Melillo, Rosa Marina, primary, Fusco, Alfredo, primary, Bittner, Michael L., primary, and Santoro, Massimo, primary

Published
2023
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47. Supplementary Table 4 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Author

Salvatore, Giuliana, primary, Nappi, Tito Claudio, primary, Salerno, Paolo, primary, Jiang, Yuan, primary, Garbi, Corrado, primary, Ugolini, Clara, primary, Miccoli, Paolo, primary, Basolo, Fulvio, primary, Castellone, Maria Domenica, primary, Cirafici, Anna Maria, primary, Melillo, Rosa Marina, primary, Fusco, Alfredo, primary, Bittner, Michael L., primary, and Santoro, Massimo, primary

Published
2023
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48. Supplementary Table 5 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Author

Salvatore, Giuliana, primary, Nappi, Tito Claudio, primary, Salerno, Paolo, primary, Jiang, Yuan, primary, Garbi, Corrado, primary, Ugolini, Clara, primary, Miccoli, Paolo, primary, Basolo, Fulvio, primary, Castellone, Maria Domenica, primary, Cirafici, Anna Maria, primary, Melillo, Rosa Marina, primary, Fusco, Alfredo, primary, Bittner, Michael L., primary, and Santoro, Massimo, primary

Published
2023
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49. Supplementary Table 2 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Author

Salvatore, Giuliana, primary, Nappi, Tito Claudio, primary, Salerno, Paolo, primary, Jiang, Yuan, primary, Garbi, Corrado, primary, Ugolini, Clara, primary, Miccoli, Paolo, primary, Basolo, Fulvio, primary, Castellone, Maria Domenica, primary, Cirafici, Anna Maria, primary, Melillo, Rosa Marina, primary, Fusco, Alfredo, primary, Bittner, Michael L., primary, and Santoro, Massimo, primary

Published
2023
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50. Supplementary Table 1 from A Cell Proliferation and Chromosomal Instability Signature in Anaplastic Thyroid Carcinoma

Author

Salvatore, Giuliana, primary, Nappi, Tito Claudio, primary, Salerno, Paolo, primary, Jiang, Yuan, primary, Garbi, Corrado, primary, Ugolini, Clara, primary, Miccoli, Paolo, primary, Basolo, Fulvio, primary, Castellone, Maria Domenica, primary, Cirafici, Anna Maria, primary, Melillo, Rosa Marina, primary, Fusco, Alfredo, primary, Bittner, Michael L., primary, and Santoro, Massimo, primary

Published
2023
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