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1. Thyroid surgery during the COVID-19 pandemic: difficulties – how to improve

Author

Stefanou Christos K., Papathanakos Georgios, Stefanou Stefanos K., Tepelenis Kostas, Kitsouli Aikaterini, Barbouti Alexandra, Flindris Stefanos, Tsoumanis Periklis, Kanavaros Panagiotis, and Kitsoulis Panagiotis

Subjects
covid-19 pandemic, fine needle aspiration cytology, preoperative diagnosis, thyroid surgery, translaryngeal ultrasonography, Surgery, RD1-811
Abstract

In December 2019, the new coronavirus infection (COVID-19) was declared a pandemic by the World Health Organization after rapidly spreading over the world in just a few months. All elective operations and nonemergency treatments have been postponed worldwide. However, some patients require surgical therapy as well, and the time spent waiting should not have a negative impact on the surgical outcome or disease course. Following the initial onset of the COVID-19 epidemic, instructions for proper and safe surgery for healthcare staff and patients should develop. Thyroid surgeries have decreased during the COVID-19 pandemic. Most of them can be postponed for a long time. Assessment of thyroid nodules recommends clinical examination, imaging studies, fine needle aspiration (FNA) and vocal cord examination. All these procedures are necessary, and sometimes they cannot be postponed. To determine the best timing, a thorough preoperative assessment should be undertaken, taking into account both oncological and anatomical features. Furthermore, COVID-19 status must be negative prior to any intervention, and hospital infrastructure must be ready to deal with the demanding situation.

Published
2022
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2. Surgical tips and techniques to avoid complications of thyroid surgery

Author

Stefanou Christos K, Papathanakos Georgios, Stefanou Stefanos K, Tepelenis Kostas, Kitsouli Aikaterini, Barbouti Alexandra, Tsoumanis Periklis, Kanavaros Panagiotis, and Kitsoulis Panagiotis

Subjects
complications, hemorrhage, hypoparathyroidism, recurrent laryngeal nerve, superior laryngeal nerve, thyroid surgery, thyrotoxic storm, Surgery, RD1-811
Abstract

Surgery of the thyroid takes place in a body part with complicated anatomy and several vital physiologic functions. Thyroidectomy is rarely associated with mortality but can be followed by significant complications, (i.e. hypoparathyroidism, hemorrhage, upper airway obstruction, laryngeal nerve injuries and thyrotoxic storm). This review aims to indicate surgical tips and techniques to sustain a low level of complications.

Published
2022
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5. Transanal total mesorectal excision: Understanding indications, managing complications, and effective prevention methods.

Author

Stefanou, Christos K., Stefanou, Stefanos K., Tepelenis, Kostas, Chatzoglou, Theocharis, Smyris, Thomas Iraklis, Aikaterini, Marini, Barbouti, Alexandra, Varvarousis, Dimitrios N., Kanavaros, Panagiotis, and Kitsoulis, Panagiotis

Subjects
SURGICAL site, OPERATIVE surgery, RECTAL cancer, NERVOUS system injuries, URINARY organs, RECTAL surgery
Abstract

Transanal total mesorectal excision (TaTME) has emerged as a surgical method for treating rectal malignancies in the middle and lower third of the rectum over the past 15 years. This approach was adopted because of the challenges encountered in secure total mesorectal excision (TME). Patient selection criteria and the rationale for TaTME have evolved, leading to improved oncological outcomes and patient quality of life. The procedure includes inserting a unique platform through the anus, forming a purse‐string closure, and endoscopically sealing the lower rectum. The mesorectum is then removed laparoscopically following a 'down‐to‐up' approach, finalised with a transabdominal laparoscopic phase and anastomosis. Pelvic anatomy complexity poses challenges, including potential injuries to the urinary tract, surgical site leakage, sinus damage, sagittal vein harm, nerve injury, carbon dioxide embolism, bowel function disturbance, sphincter mechanism issues, and rectal abscess formation. Proficient anatomy knowledge, precise surgical techniques, and advanced technologies contribute to their prevention. In conclusion, TaTME offers a promising approach to rectal surgery with satisfactory oncological outcomes. However, vigilance is required to eliminate potential complications. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Anatomical variations of the great saphenous vein at the saphenofemoral junction. A cadaveric study and narrative review of the literature.

Author

Tepelenis, Kostas, Papathanakos, Georgios, Kitsouli, Aikaterini, Barbouti, Alexandra, Varvarousis, Dimitrios N, Kefalas, Athanasios, Anastasopoulos, Nikolaos, Paraskevas, Georgios, and Kanavaros, Panagiotis

Abstract

Objectives: The great saphenous vein is the lower limb's longest and thickest-walled superficial vein. Its anatomy is complex, while its anatomical variations are widespread. This study aimed to illustrate the anatomy and variations of the great saphenous vein at the saphenofemoral junction. Methods: The study was conducted on 75 fresh-frozen cadaveric lower limbs. Cadavers with evidence of prior leg surgery or trauma and any congenital abnormality or gross deformity were excluded. The saphenofemoral junction was studied in detail with emphasis on the number, incidence, draining pattern of tributaries, and duplication of the great saphenous vein. Results: Out of the 75 cadaveric lower limbs, 57.3% were obtained from males, and 42.7% were obtained from females. The mean age of the cadaveric lower extremities was 66.6 years (range 42–91). The number of tributaries at the saphenofemoral junction varied from 0 to 7, with a mean of 3.8. The most frequent number of branches was 4–5 in 61.3% of cases. The most consistent tributary was the superficial external pudendal vein, while the posterior accessory great saphenous vein was the least frequent tributary. 80% of the branches drained into the saphenofemoral junction directly (53.3%) or by a common trunk (26.7%%). The most frequent common trunk was the superficial epigastric and superficial circumflex iliac vein (10.7%). The rest 20% of the tributaries drained directly into the common femoral vein. The commonest branch reaching the common femoral vein was the superficial external pudendal vein (10.7%). Duplication of the great saphenous vein was observed in 2.7% of the cases. Conclusions: There is a significant variation of tributaries at the saphenofemoral junction regarding the number, incidence, draining pattern of branches, and duplication of the great saphenous vein. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Prevalence and risk factors of phlebosclerosis in the great saphenous vein.

Author

Tepelenis, Kostas, Papathanakos, Georgios, Kitsouli, Aikaterini, Barbouti, Alexandra, Varvarousis, Dimitrios N, Kefalas, Athanasios A, Anastasopoulos, Nikolaos, Paraskevas, Georgios, and Kanavaros, Panagiotis

Abstract

Objectives: Phlebosclerosis is a fibrous degeneration of the vein wall, predominantly the intima, with or without calcification. The prevalence and etiology of phlebosclerosis of the great saphenous vein are not well documented. This study aimed to estimate the prevalence and define the risk factors of phlebosclerosis of the great saphenous vein. Methods: The study was conducted on 300 volunteers who underwent duplex ultrasound. Volunteers with symptoms and signs of acute or chronic venous disease or known varicose veins, thrombosis, chronic vein insufficiency, and any operation in the lower extremities were excluded. The imaging hallmarks of phlebosclerosis include wall brightness, calcification, and increased wall thickness. Demographics of the volunteers (sex, age, weight, and height), Body Mass Index (BMI) and the presence of smoking, hypertension, diabetes mellitus, and dyslipidemia were recorded. Data obtained were consolidated and statistically evaluated using SPSS Version 16. Results: Of the 300 volunteers who underwent duplex ultrasound, 60.3% were females, and 39.7% were males. The mean age was 60 ± 13, while the mean BMI was 26.01 ± 4.76. Moreover, 66.3% were non-smokers, and 62.3%, 81.3%, and 58.7% did not suffer from hypertension, diabetes mellitus, and dyslipidemia, respectively. The prevalence of phlebosclerosis was found to be 2.3%. Hypertension was a risk factor for the development of phlebosclerosis (p = 0.045). Moreover, there was a link between phlebosclerosis and age, as volunteers with phlebosclerosis were older than volunteers without phlebosclerosis (74.2 vs 59.11 years, p < 0.001). Conclusions: The prevalence of phlebosclerosis of the great saphenous vein is low, specifically 2.3%. Hypertension and increased age are risk factors for the development of phlebosclerosis. Both sexes are equally affected, while BMI, smoking, diabetes mellitus, and dyslipidemia do not contribute to the development of phlebosclerosis. [ABSTRACT FROM AUTHOR]

Published
2024
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10. List of contributors

Author

Abia, Rocio, primary, Abouloifa, H., additional, Adriana, Morales-Martínez, additional, Aggarwal, Diwakar, additional, Aggarwal, Vaishali, additional, Alicia, Sánchez-Mendoza, additional, Andreadou, Ioanna, additional, Angeles-Lo´pez, Quetzalli D., additional, Argüelles, Sandro, additional, Asehraou, A., additional, Audi, Namaa, additional, Ayala, Antonio, additional, Ayoub, Nehad M., additional, Badiu, Diana, additional, Badria, Farid A., additional, Barbouti, Alexandra, additional, Batanero, Eva, additional, Batarseh, Yazan S., additional, Baumann, Leslie S., additional, Ben Salah, R., additional, Bermudez, Beatriz, additional, Blanco, Santos, additional, Borras-Linares, Isabel, additional, Brasca, M., additional, Brenes, Manuel, additional, Perez-Calabuig, Ana M., additional, Cancilla, John C., additional, Cano, Mercedes, additional, Carbone, Fabrizio, additional, Carrera-González, María Pilar, additional, Casas, Rosa, additional, Ceccanti, Mauro, additional, Chaldakov, George N., additional, Covas, María-Isabel, additional, Culeddu, Nicola, additional, Cumaoğlu, Ahmet, additional, Curiel, José Antonio, additional, Damiano, Fabrizio, additional, de Castro, Antonio, additional, de Felipe, Félix López, additional, de la Torre, Rafael, additional, de las Rivas, Blanca, additional, Deiana, Pierfrancesco, additional, Dekanski, Dragana, additional, Dettori, Sandro, additional, Di Stefano, Vita, additional, Domínguez-Vías, German, additional, Dore, Antonio, additional, D’hallewin, G., additional, El Sayed, Khalid A., additional, Elgazar, Abdullah A., additional, Emanuelli, Tatiana, additional, Ferraguti, Giampiero, additional, Filigheddu, Maria Rosaria, additional, Fiore, Marco, additional, Fitó, Montserrat, additional, Francisca, Pérez-Severiano, additional, Fujiwara, Yoko, additional, Galaris, Dimitrios, additional, García, Pedro, additional, Ghabbour, N., additional, Giudetti, Anna Maria, additional, Gnoni, Antonio, additional, Gnoni, Gabriele Vincenzo, additional, Goulas, Vlasios, additional, Greco, Antonio, additional, Guclu, Gamze, additional, Haghbeen, Kamahldin, additional, Handjani, Farhad, additional, Heydari, Mojtaba, additional, Hosseini Mazinani, Mehdi, additional, Ishikawa, Tomoko, additional, Iuliano, Luigi, additional, Joel, Jiménez-Gómez, additional, Joshi, Asavari, additional, Juan, M. Emília, additional, Jugreet, Bibi Sharmeen, additional, Kaddoumi, Amal, additional, Kailis, Stanley George, additional, Kanavaros, Panagiotis, additional, Karboune, S., additional, Kelebek, Hasim, additional, Kitsoulis, Panagiotis, additional, Kouka, Paraskevi, additional, Kouretas, Demetrios, additional, Ktari, N., additional, Kumar, Gaurav, additional, Kumar, Manoj, additional, Landete, José María, additional, Lauretti, Elisabetta, additional, Lemus-Conejo, Ana, additional, Lombardo, Luca, additional, Longo, Serena, additional, Pradana-Lopez, Sandra, additional, Lopez, Sergio, additional, Lopez-Millan, Belen, additional, López-López, Antonio, additional, Lozano-Sánchez, Jesús, additional, Madar, Zecharia, additional, Mahomoodally, Mohamad Fawzi, additional, Mañas, Mariano, additional, Martinez-Victoria, Emilio, additional, Martinez-Burgos, Maria Alba, additional, Martínez-Martos, José Manuel, additional, Masre, Siti Fathiah, additional, Medina, Eduardo, additional, Medina, Rafael, additional, Menendez, Javier A., additional, Millan-Linares, Maria C., additional, Mittal, Sonam, additional, Mohammadnejad, Parvin, additional, Molinu, Maria Giovanna, additional, Montaño, Alfredo, additional, Montserrat-de la Paz, Sergio, additional, Muñoz, Mario, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Nenadis, N., additional, Nychas, G.-J.E., additional, Ortega-García, Francisca, additional, Ortega-Gomez, Almudena, additional, Pacheco, Yolanda M., additional, Panagou, E.Z., additional, Papoti, V.T., additional, Pariente, Jose Antonio, additional, Parvizi, Mohammad Mahdi, additional, Pathak, Kaveri, additional, Peinado, M. Ángeles, additional, Peragón, Juan, additional, Petrella, Carla, additional, Čabarkapa-Pirkovic, Andrea, additional, Planas, Joana M., additional, Plastina, Pierluigi, additional, Praticò, Domenico, additional, Prieto, Isabel, additional, Rajendram, Rajkumar, additional, Ralli, Massimo, additional, Ramírez-Expósito, María Jesús, additional, Ramírez-Sánchez, Manuel, additional, Rasouli, Hassan, additional, Al Rihani, Sweilem B., additional, Rodríguez, Héctor, additional, Rodríguez-López, Paloma, additional, Rokni, Y., additional, Romero, Concepción, additional, Rosillo, Maria A., additional, Ruiz-Barba, José Luis, additional, Saalaoui, E., additional, Sacanella, Emilio, additional, Sadeer, Nabeelah Bibi, additional, Sak, Katrin, additional, Saki, Maryam, additional, Salimonti, Amelia, additional, Sánchez, Antonio-Higinio, additional, Santona, Mario, additional, Segarra, Ana Belén, additional, Segura-Carretero, Antonio, additional, Selli, Serkan, additional, Sergio, Montes, additional, Sethi, Gautam, additional, Seyedebrahimi, Seyede Sanaz, additional, Shahbaz, Mana, additional, Sharma, Dhvani, additional, Soares, Mario J, additional, Spremo-Potparević, Biljana, additional, Stark, Aliza Hannah, additional, Suroowan, Shanoo, additional, Suvarna, Vasanti, additional, Tahiri, Iasim, additional, Tarani, Luigi, additional, Tassou, C.C., additional, Topalović, Dijana, additional, Torrecilla, José S., additional, Tseti, Ioulia, additional, Tsimidou, M.Z., additional, Tsoumani, Maria, additional, Tuli, Hardeep Singh, additional, Varela, Lourdes M., additional, Veskoukis, Aristidis S., additional, Villalba, Mayte, additional, Weisberg, Edmund M., additional, Yago, Maria Dolores, additional, Yang, Euitaek, additional, Yerer, Mükerrem Betül, additional, Zanwar, Anand, additional, Zelasco, Samanta, additional, and Živković, Lada, additional

Published
2021
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11. Exploiting the beneficial effects of Salvia officinalis L. extracts in human health and assessing their activity as potent functional regulators of food microbiota

Author

Kompoura, Vasiliki, primary, Karapantzou, Ioanna, additional, Mitropoulou, Gregoria, additional, Parisis, Nikolaos A., additional, Gkalpinos, Vasileios K., additional, Anagnostou, Vasiliki A., additional, Tsiailanis, Antonis D., additional, Vasdekis, Efstathios P., additional, Koutsaliaris, Ioannis K., additional, Tsouka, Aikaterini N., additional, Karapetsi, Lefkothea, additional, Madesis, Panagiotis, additional, Letsiou, Stavroula, additional, Florou, Dimitra, additional, Koukkou, Anna-Irini, additional, Barbouti, Alexandra, additional, Tselepis, Alexandros D., additional, Kourkoutas, Yiannis, additional, and Tzakos, Andreas G., additional

Published
2023
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13. Anatomical variations of the great saphenous vein at the saphenofemoral junction. A cadaveric study and narrative review of the literature

Author

Tepelenis, Kostas, primary, Papathanakos, Georgios, additional, Kitsouli, Aikaterini, additional, Barbouti, Alexandra, additional, Varvarousis, Dimitrios N, additional, Kefalas, Athanasios, additional, Anastasopoulos, Nikolaos, additional, Paraskevas, Georgios, additional, and Kanavaros, Panagiotis, additional

Published
2023
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19. The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma.

Author

Anastasopoulos, Nikolaos-Andreas, Charchanti, Antonia V., Barbouti, Alexandra, Mastoridou, Eleftheria M., Goussia, Anna C., Karampa, Anastasia D., Christodoulou, Dimitrios, and Glantzounis, Georgios K.

Subjects
FATTY liver, HEPATOCELLULAR carcinoma, OXIDATIVE stress, PATHOGENESIS, DISEASE progression, CELLULAR aging
Abstract

Hepatocellular carcinoma (HCC) represents a worryingly increasing cause of malignancy-related mortality, while Metabolic Associated Fatty Liver Disease (MAFLD) is going to become its most common cause in the next decade. Understanding the complex underlying pathophysiology of MAFLD-related HCC can provide opportunities for successful targeted therapies. Of particular interest in this sequela of hepatopathology is cellular senescence, a complex process characterised by cellular cycle arrest initiated by a variety of endogenous and exogenous cell stressors. A key biological process in establishing and maintaining senescence is oxidative stress, which is present in multiple cellular compartments of steatotic hepatocytes. Oxidative stress-induced cellular senescence can change hepatocyte function and metabolism, and alter, in a paracrine manner, the hepatic microenvironment, enabling disease progression from simple steatosis to inflammation and fibrosis, as well as HCC. The duration of senescence and the cell types it affects can tilt the scale from a tumour-protective self-restricting phenotype to the creator of an oncogenic hepatic milieu. A deeper understanding of the mechanism of the disease can guide the selection of the most appropriate senotherapeutic agent, as well as the optimal timing and cell type targeting for effectively combating HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Oxidative Stress-Induced Cellular Senescence: Is Labile Iron the Connecting Link?

Author

Nousis, Lambros, Kanavaros, Panagiotis, and Barbouti, Alexandra

Subjects
CELLULAR aging, REACTIVE oxygen species, IRON, FREE radicals, CELL physiology, OXIDATIVE stress
Abstract

Cellular senescence, a cell state characterized by a generally irreversible cell cycle arrest, is implicated in various physiological processes and a wide range of age-related pathologies. Oxidative stress, a condition caused by an imbalance between the production and the elimination of reactive oxygen species (ROS) in cells and tissues, is a common driver of cellular senescence. ROS encompass free radicals and other molecules formed as byproducts of oxygen metabolism, which exhibit varying chemical reactivity. A prerequisite for the generation of strong oxidizing ROS that can damage macromolecules and impair cellular function is the availability of labile (redox-active) iron, which catalyzes the formation of highly reactive free radicals. Targeting labile iron has been proven an effective strategy to counteract the adverse effects of ROS, but evidence concerning cellular senescence is sparse. In the present review article, we discuss aspects of oxidative stress-induced cellular senescence, with special attention to the potential implication of labile iron. [ABSTRACT FROM AUTHOR]

Published
2023
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28. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. Beatriz P.P., additional, Orihara, Yutaka, additional, Ortega, Almudena, additional, Ortega-García, Francisca, additional, Osada, Jesús, additional, Özdemir, Durmuş, additional, Öztürk, Betül, additional, Pacheco, Yolanda M., additional, Paice, Alistair G., additional, Palmerini, Carlo A., additional, Panagiotakos, Demosthenes, additional, Panagou, E.Z., additional, Panzella, Lucia, additional, Papoti, V.T., additional, Paradiso, Vito Michele, additional, Pariente, José Antonio, additional, Patel, Vinood B., additional, Peinado, M. Ángeles, additional, Pellicanò, Teresa Maria, additional, Peragon, Juan, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Perona, Javier Sanchez, additional, Piperno, Anna, additional, Planas, Joana M., additional, Pollicino, Donatella, additional, Polzonetti, Valeria, additional, Populin, Tiziana, additional, Portillo, Maria P., additional, Pozo, David, additional, Prenzler, Paul, additional, Prieto, Pablo G., additional, Pucciarelli, Stefania, additional, Puel, Caroline, additional, Puertollano, Elena, additional, Puertollano, María A., additional, Quesada-Granados, Jose Javier, additional, Rajendram, Rajkumar, additional, Ramírez-Expósito, María Jesús, additional, Ramos, Sonia, additional, Ramos-Martos, Natividad, additional, Randazzo, Cinzia L., additional, Rando, Rossana, additional, Reiter, Russel J., additional, Rejano, Luis, additional, Rhee, Hae-Ik, additional, Robards, Kevin, additional, Rodriguez, Hector, additional, Rodríguez-Cabezas, Maria Elena, additional, Rodríguez-Manero, Moises, additional, Rodríguez-Méndez, María L., additional, Rodríguez, Rosalía, additional, Rodriguez-Rodriguez, Rosalia, additional, Romani, Annalisa, additional, Romero, Concepción, additional, Romero, Maria-Paz, additional, Romero-Gonzalez, Roberto, additional, Rose, Martin, additional, Rossi, Mauro, additional, Rotondi, Annalisa, additional, Rowland, Ian R., additional, Ruiz, Adolfina, additional, Ruiz-Gutiérrez, Valentina, additional, Russo, Francesco, additional, Ryan, Danielle, additional, Sabatini, Nadia, additional, Sacco, Antonio, additional, Sahan, Yasemin, additional, Saitta, Marcello, additional, Salvador, Maria Desamparados, additional, Samperi, Roberto, additional, Samaniego-Sánchez, Cristina, additional, Sánchez, Antonio Higinio, additional, Sánchez-Navarro, Maria Rosa, additional, Sancho, Verónica, additional, Santos-González, Mónica, additional, Saraiva, Jorge A., additional, Scampicchio, Matteo, additional, Scazzocchio, Beatrice, additional, Schmitt, Christoph A., additional, Schwartz, Betty, additional, Sciuto, Sebastiano, additional, Scoditti, Egeria, additional, Seabra, Rosa M., additional, Sebastiani, Luca, additional, Segre, Anna Laura, additional, Segura, Antonio, additional, Servili, Maurizio, additional, Shiraishi, Ryosuke, additional, Siculella, Luisa, additional, Simão, Andréa Colado, additional, Sindona, Giovanni, additional, Sivakumar, Ganapathy, additional, Skaltsounis, Alexios-Leandros, additional, Smith, Amos B., additional, Spatafora, Carmela, additional, Sperry, Jeffrey B., additional, Soares, Mario J., additional, Soriguer, Federico, additional, Srirajaskanthan, Rajaventhan, additional, Stitia, Naïm, additional, Tabernero, Arantxa, additional, Tagarelli, Antonio, additional, Tai, Fuju, additional, Tamborrino, Antonia, additional, Tassou, C.C., additional, Tesseromatis, Christine, additional, Todeschini, Roberto, additional, Torrecilla, Jose S., additional, Trikib, Saïda, additional, Tringali, Corrado, additional, Tsakiris, Ioannis N., additional, Tsatsakis, Aristidis M., additional, Tsimidou, M.Z., additional, Uccella, Nicola A., additional, Urbano, Francisco J., additional, Valcarcel, Miguel, additional, Valencia-Serrano, Félix, additional, Valentão, Patrícia, additional, Valverde, Isabel, additional, Varela, Lourdes M., additional, Varì, Rosaria, additional, Simas Vaz, Fernando Antonio, additional, Vettorazzi, Ariane, additional, Vichi, Stefania, additional, Vidal, José Luis Martínez, additional, Villalba, José M., additional, Villalba, Mayte, additional, Villanueva-Peñacarrillo, María L., additional, Vincenzetti, Silvia, additional, Vita, Alberto, additional, Vlahov, Giovanna, additional, Wang, Wei, additional, Weisberg, Edmund, additional, Wenzel, Uwe, additional, Won, Se-Ra, additional, Wu, Bin, additional, Yago, María Dolores, additional, Zabaras, Dimitrios, additional, Zappia, Vincenzo, additional, Zarzuelo, Antonio, additional, and Zhang, Luyong, additional

Published
2010
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31. Osteoid Osteoma: An Updated Review of Epidemiology, Pathogenesis, Clinical Presentation, Radiological Features, and Treatment Option

Author

TEPELENIS, KOSTAS, primary, SKANDALAKIS, GEORGIOS P., additional, PAPATHANAKOS, GEORGIOS, additional, KEFALA, MARIA ALEXANDRA, additional, KITSOULI, AIKATERINI, additional, BARBOUTI, ALEXANDRA, additional, TEPELENIS, NIKOLAOS, additional, VARVAROUSIS, DIMITRIOS, additional, VLACHOS, KONSTANTINOS, additional, KANAVAROS, PANAGIOTIS, additional, and KITSOULIS, PANAGIOTIS, additional

Published
2021
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32. Adamantinoma: An Updated Review

Author

VARVAROUSIS, DIMITRIOS N., primary, SKANDALAKIS, GEORGIOS P., additional, BARBOUTI, ALEXANDRA, additional, PAPATHANAKOS, GEORGIOS, additional, FILIS, PANAGIOTIS, additional, TEPELENIS, KOSTAS, additional, KITSOULI, AIKATERINI, additional, KANAVAROS, PANAGIOTIS, additional, and KITSOULIS, PANAGIOTIS, additional

Published
2021
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33. Phlebosclerosis in lower extremities veins – a systematic review

Author

Tepelenis, Kostas, primary, Papathanakos, Georgios, additional, Barbouti, Alexandra, additional, Paraskevas, Georgios, additional, Kitsouli, Aikaterini, additional, Alexandra Kefala, Maria, additional, Tepelenis, Nikolaos, additional, Kanavaros, Panagiotis, additional, and Kitsoulis, Panagiotis, additional

Published
2020
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34. Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

Author

Barbouti, Alexandra, Vasileiou, Panagiotis V. S., Evangelou, Konstantinos, Vlasis, Konstantinos G., Papoudou-Bai, Alexandra, Gorgoulis, Vassilis G., and Kanavaros, Panagiotis

Subjects
Article Subject
Abstract

The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity and prevention of systemic autoimmunity, the thymus is the first organ of the body that exhibits age-associated degeneration/regression, termed “thymic involution.” A hallmark of this early phenomenon is a progressive decline of thymic mass as well as a decreased output of naïve T cells, thus resulting in impaired immune response. Importantly, thymic involution has been recently linked with cellular senescence which is a stress response induced by various stimuli. Accumulation of senescent cells in tissues has been implicated in aging and a plethora of age-related diseases. In addition, several lines of evidence indicate that oxidative stress, a well-established trigger of senescence, is also involved in thymic involution, thus highlighting a possible interplay between oxidative stress, senescence, and thymic involution.

Published
2020
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42. Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract

Author

Spanou, Evagelia, primary, Kalisperati, Polyxeni, additional, Pateras, Ioannis S., additional, Papalampros, Alexandros, additional, Barbouti, Alexandra, additional, Tzioufas, Athanasios G., additional, Kotsinas, Athanassios, additional, and Sougioultzis, Stavros, additional

Published
2017
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