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125 results on '"BALBI, TIZIANA"'

4. Thirteen‐gene DNA methylation analysis of oral brushing samples: A potential surveillance tool for periodic monitoring of treated patients with oral cancer

Author

Gissi, Davide B., primary, Rossi, Roberto, additional, Lenzi, Jacopo, additional, Tarsitano, Achille, additional, Gabusi, Andrea, additional, Balbi, Tiziana, additional, Montebugnoli, Lucio, additional, Marchetti, Claudio, additional, Foschini, Maria Pia, additional, and Morandi, Luca, additional

Published
2024
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6. Pre-operative incisional biopsy of oral squamous cell carcinoma: high podoplanin expression is related to perineural invasion and may be a useful predictor of disease progression

Author

Gabusi, Andrea, primary, Asioli, Sofia, additional, Fabbri, Viscardo P., additional, Fellegara, Giovanni, additional, Gibertoni, Dino, additional, Rossi, Roberto, additional, Battaglia, Salvatore, additional, Tarsitano, Achille, additional, Balbi, Tiziana, additional, Marchetti, Claudio, additional, Montebugnoli, Lucio, additional, Foschini, Maria Pia, additional, and Gissi, Davide B., additional

Published
2023
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10. Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota

Author

Piazzi, Giulia, DʼArgenio, Giuseppe, Prossomariti, Anna, Lembo, Vincenzo, Mazzone, Giovanna, Candela, Marco, Biagi, Elena, Brigidi, Patrizia, Vitaglione, Paola, Fogliano, Vincenzo, DʼAngelo, Leonarda, Fazio, Chiara, Munarini, Alessandra, Belluzzi, Andrea, Ceccarelli, Claudio, Chieco, Pasquale, Balbi, Tiziana, Loadman, Paul M., Hull, Mark A., Romano, Marco, Bazzoli, Franco, and Ricciardiello, Luigi

Published
2014
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19. A mediterranean diet mix has chemopreventive effects in a murine model of colorectal cancer modulating apoptosis and the gut microbiota

Author

Piazzi, Giulia, Prossomariti, Anna, Baldassarre, Maurizio, Montagna, Claudio, Vitaglione, Paola, Fogliano, Vincenzo, Biagi, Elena, Candela, Marco, Brigidi, Patrizia, Balbi, Tiziana, Munarini, Alessandra, Belluzzi, Andrea, Pariali, Milena, Bazzoli, Franco, Ricciardiello, Luigi, Piazzi, Giulia, Prossomariti, Anna, Baldassarre, Maurizio, Montagna, Claudio, Vitaglione, Paola, Fogliano, Vincenzo, Biagi, Elena, Candela, Marco, Brigidi, Patrizia, Balbi, Tiziana, Munarini, Alessandra, Belluzzi, Andrea, Pariali, Milena, Bazzoli, Franco, and Ricciardiello, Luigi

Abstract

Objectives: Unhealthy dietary patterns have been associated with colorectal cancer (CRC) onset while Mediterranean Diet (MD) has been proposed for CRC prevention. This study evaluated the effect of a Mediterranean Diet Mix (MD-MIX) on colonic tumors development in A/J mice fed a low-fat (LFD) or a high-fat western diet (HFWD), and injected with the procarcinogen azoxymethane (AOM). Materials and Methods: Forty A/J male mice were randomly assigned into four feeding arms (10 mice/arm; LFD, LFD-MD-MIX, HFWD, HFWD-MD-MIX) to be treated with AOM. Ten mice were exposed to the diets alone (Healthy LFD and Healthy HFWD) to be used as control. Tumor incidence and multiplicity were evaluated at sacrifice. Mucosal fatty acid content and urinary phenolic compounds were assayed by mass spectrometry. Apoptosis was evaluated by TUNEL assay and gene expression markers. Cell proliferation was evaluated by Ki67 immunohistochemistry. Microbiota composition was assessed at different time points by 16S RNA sequencing. Results: A tumor incidence of 100% was obtained in AOM-treated mice. The MD-MIX supplementation was able to reduce the number of colonic lesions in both LFD and HFWD-fed mice and to induce apoptosis, in particular in the LFD-MD-MIX arm. Moreover, a preventive effect on low-grade dysplasia and macroscopical lesions (>1 mm) development was found in HFWD-fed mice together with a regulation of the AOM-driven intestinal dysbiosis. Conclusions: MD-MIX was able to counteract CRC development in mice under different dietary backgrounds through the regulation of apoptosis and gut microbiota.

Published
2019

22. A Mediterranean Diet Mix Has Chemopreventive Effects in a Murine Model of Colorectal Cancer Modulating Apoptosis and the Gut Microbiota

Author

Piazzi, Giulia, primary, Prossomariti, Anna, additional, Baldassarre, Maurizio, additional, Montagna, Claudio, additional, Vitaglione, Paola, additional, Fogliano, Vincenzo, additional, Biagi, Elena, additional, Candela, Marco, additional, Brigidi, Patrizia, additional, Balbi, Tiziana, additional, Munarini, Alessandra, additional, Belluzzi, Andrea, additional, Pariali, Milena, additional, Bazzoli, Franco, additional, and Ricciardiello, Luigi, additional

Published
2019
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23. Multi-Region Sequence Analysis of a Pregnancy-Related Oral Squamous Cell Carcinoma Exhibiting Low-Level Aggressive Behavior.

Author

Gissi, Davide Bartolomeo, Gabusi, Andrea, Tarsitano, Achille, Rossi, Roberto, Balbi, Tiziana, and Morandi, Luca

Subjects
SQUAMOUS cell carcinoma, CANCER invasiveness, ORAL mucosa, SEQUENCE analysis, DNA analysis, DNA methylation
Abstract

We analyzed the genetic and epigenetic profiles of an oral squamous cell carcinoma affecting a 41-year-old pregnant female. The patient presented with an oral mass located at the hard and soft palate with bone involvement and lymph node metastases (T4N1M0). She had been treated with multimodal radiotherapy and chemotherapy, and she is currently alive with no evidence of disease 8 years after treatment. DNA methylation and DNA mutation analyses were used to analyze multiple samples from the tumor mass and from the non-neoplastic mucosa to verify tumor heterogeneity. Genetic and epigenetic analyses revealed the presence of one shared TP53 driver mutation with the same DNA methylation profile in each of the 3 areas of the tumor mass; only 2 additional passenger mutations were detected, suggesting a simple clonal homogeneous carcinoma, which usually is associated with low-level aggressive behavior. Additionally, no genetic or epigenetic alteration in the non-neoplastic oral mucosa was detected, demonstrating the absence of field cancerization. The low aggressiveness of the lesion was confirmed by the patient being free of disease at a long-term follow-up examination. These data suggest a different molecular transformation pathway in pregnancy-related oral squamous cell carcinomas, providing new perspectives for further investigation. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Somatic APC mosaicism and oligogenic inheritance in genetically unsolved colorectal adenomatous polyposis patients

Author

Ciavarella, Michele, primary, Miccoli, Sara, additional, Prossomariti, Anna, additional, Pippucci, Tommaso, additional, Bonora, Elena, additional, Buscherini, Francesco, additional, Palombo, Flavia, additional, Zuntini, Roberta, additional, Balbi, Tiziana, additional, Ceccarelli, Claudio, additional, Bazzoli, Franco, additional, Ricciardiello, Luigi, additional, Turchetti, Daniela, additional, and Piazzi, Giulia, additional

Published
2018
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25. Short-term treatment with eicosapentaenoic acid improves inflammation and affects colonic differentiation markers and microbiota in patients with ulcerative colitis

Author

Prossomariti, Anna, primary, Scaioli, Eleonora, additional, Piazzi, Giulia, additional, Fazio, Chiara, additional, Bellanova, Matteo, additional, Biagi, Elena, additional, Candela, Marco, additional, Brigidi, Patrizia, additional, Consolandi, Clarissa, additional, Balbi, Tiziana, additional, Chieco, Pasquale, additional, Munarini, Alessandra, additional, Pariali, Milena, additional, Minguzzi, Manuela, additional, Bazzoli, Franco, additional, Belluzzi, Andrea, additional, and Ricciardiello, Luigi, additional

Published
2017
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26. Somatic APC Mosaicism Causes a High Proportion of Unexplained Colorectal Polyposis

Author

Piazzi, Giulia, primary, Ciavarella, Michele, additional, Miccoli, Sara, additional, Bonora, Elena, additional, Buscherini, Francesco, additional, Pippucci, Tommaso, additional, Palombo, Flavia, additional, Prossomariti, Anna, additional, Zuntini, Roberta, additional, Balbi, Tiziana, additional, Bazzoli, Franco, additional, Turchetti, Daniela, additional, and Ricciardiello, Luigi, additional

Published
2017
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27. Eicosapentaenoic Acid-Free Fatty Reduces Fecal Calprotectin Levels and Affects Colitis-Associated Colorectal Cancer Pathways in Patients with Long-Standing Ulcerative Colitis

Author

Prossomariti, Anna, primary, Scaioli, Eleonora, additional, Piazzi, Giulia, additional, Fazio, Chiara, additional, Bellanova, Matteo, additional, Biagi, Elena, additional, Candela, Marco, additional, Brigidi, Patrizia, additional, Consolandi, Clarissa, additional, Balbi, Tiziana, additional, Chieco, Pasquale, additional, Munarini, Alessandra, additional, Pariali, Milena, additional, Minguzzi, Manuela, additional, Bazzoli, Franco, additional, Belluzzi, Andrea, additional, and Ricciardiello, Luigi, additional

Published
2017
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29. Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota

Author

PIAZZI, GIULIA, PROSSOMARITI, ANNA, CANDELA, MARCO, BIAGI, ELENA, BRIGIDI, PATRIZIA, D'ANGELO, LEONARDA, FAZIO, CHIARA, BELLUZZI, ANDREA, CECCARELLI, CLAUDIO, CHIECO, PASQUALE, BALBI, TIZIANA, BAZZOLI, FRANCO, RICCIARDIELLO, LUIGI, Giuseppe D'Argenio, Vincenzo Lembo, Giovanna Mazzone, Paola Vitaglione, Vincenzo Fogliano, Alessandra Munarini, Paul M. Loadman, Mark A. Hull, Marco Romano, Piazzi, G, D'Argenio, G, Prossomariti, A, Lembo, V, Mazzone, G, Candela, M, Biagi, E, Brigidi, P, Vitaglione, Paola, Fogliano, Vincenzo, D'Angelo, L, Fazio, C, Munarini, A, Belluzzi, A, Ceccarelli, C, Chieco, P, Balbi, T, Loadman, Pm, Hull, Ma, Romano, M, Bazzoli, F, Ricciardiello, L., Giulia Piazzi, Giuseppe D'Argenio, Anna Prossomariti, Vincenzo Lembo, Giovanna Mazzone, Marco Candela, Elena Biagi, Patrizia Brigidi, Paola Vitaglione, Vincenzo Fogliano, Leonarda D'Angelo, Chiara Fazio, Alessandra Munarini, Andrea Belluzzi, Claudio Ceccarelli, Pasquale Chieco, Tiziana Balbi, Paul M Loadman, Mark A Hull, Marco Romano, Franco Bazzoli, and Luigi Ricciardiello

Subjects
Inflammation, Male, Receptors, Notch, Colon, Reverse Transcriptase Polymerase Chain Reaction, Microbiota, Apoptosis, COLON CANCER, Fatty Acids, Nonesterified, Colitis, Real-Time Polymerase Chain Reaction, Gastrointestinal Tract, Immunoenzyme Techniques, Mice, Inbred C57BL, NOTCH, Mice, Eicosapentaenoic Acid, Animals, lipids (amino acids, peptides, and proteins), OMEGA 3, RNA, Messenger, Colorectal Neoplasms, Cell Proliferation
Abstract

Inflammatory bowel diseases are associated with increased risk of developing colitis-associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) decreases the risk of sporadic colorectal cancer (CRC). Importantly, recent data have shown that eicosapentaenoic acid-free fatty acid (EPA-FFA) reduces polyp formation and growth in models of familial adenomatous polyposis. However, the effects of dietary EPA-FFA are unknown in CAC. We tested the effectiveness of substituting EPA-FFA, for other dietary fats, in preventing inflammation and cancer in the AOM-DSS model of CAC. The AOM-DSS protocols were designed to evaluate the effect of EPA-FFA on both initiation and promotion of carcinogenesis. We found that EPA-FFA diet strongly decreased tumor multiplicity, incidence and maximum tumor size in the promotion and initiation arms. Moreover EPA-FFA, in particular in the initiation arm, led to reduced cell proliferation and nuclear β-catenin expression, whilst it increased apoptosis. In both arms, EPA-FFA treatment led to increased membrane switch from ω-6 to ω-3 PUFAs and a concomitant reduction in PGE2 production. We observed no significant changes in intestinal inflammation between EPA-FFA treated arms and AOM-DSS controls. Importantly, we found that EPA-FFA treatment restored the loss of Notch signaling found in the AOM-DSS control and resulted in the enrichment of Lactobacillus species in the gut microbiota. Taken together, our data suggest that EPA-FFA is an excellent candidate for CRC chemoprevention in CAC.

Published
2013

30. Commentary on: Akyildiz E, Uzun I, Inanici MA, Baloglu H. Computerized image analysis in differentiation of skin lesion caused by electrocution, flame burns, and abrasion

Author

PIERINI, GIOVANNI, BALBI, TIZIANA, Mandrioli D., Pierini G., Balbi T., and Mandrioli D.

Subjects
ELETTROCUZIONE, CAMPI STATICI, MEDICINA LEGALE
Abstract

revisione sperimentale su una teoria circa l'elettrocuzione su cute umana diagnosi differenziale con le lesioni da ipertermia importanza in medicina legale e forense

Published
2012

31. Campi elettrici statici: uno studio sperimentale

Author

PIERINI, GIOVANNI, BALBI, TIZIANA, Grillini M, Mandrioli M, Predieri M, Carosielli G, Ponti F, Tortorella S., G Pierini, T Balbi, Grillini M, Mandrioli M, Predieri M, Carosielli G, Ponti F, and Tortorella S

Subjects
MICROSCOPIA ELETTRONICA A SCANSIONE, CAMPI STTAICI, ELONGAZIONE CELLULARE
Abstract

studio sperimentale sulla elongazione cellulare in campi CC e CA di bassa intensità, microscopia ottica ed elettronica a scansione

Published
2012

35. Considerazioni in tema di patologia forense riguardo una raccolta di preparati istologici del primo'900

Author

PIERINI, GIOVANNI, BALBI, TIZIANA, ARIETI, STEFANO, IESURUM, ANTONIO, DegliEsposti P., Grillini M., Mandrioli D., Carosielli G., Pierini G., Balbi T., Arieti S., Iesurum A., DegliEsposti P., Grillini M., Mandrioli D., and Carosielli G.

Subjects
ISTOLOGIA, ANATOMIA PATOLOGICA, MEDICINA LEGALE
Abstract

esame di un araccolta di preparati istologici del primo '900 da un punto di vista tecnico (leggibilità a fini diagnostici) e riflessione sulle patologie emergenti a seconda delle epoche e periodi.

Published
2010

36. Forensic Pathology by Scanning Electron Microscopy

Author

PIERINI, GIOVANNI, BALBI, TIZIANA, DEGLI ESPOSTI, PAOLA, IESURUM, ANTONIO, CICOGNANI, ALBERTO, M. Grillini, G. Pierini, T. Balbi, M. Grillini, P. Degli Esposti, A. Iesurum, and A. Cicognani

Subjects
FORENSIC PATHOLOGY
Abstract

An atlas of scanning electronic microscopy (SEM) may turn out to be useful for studying the many issues that are submitted to the coroner’s attention. It may also offer interesting ideas to experts of biomedical subjects who are still interested in pushing back the frontiers of scientific explanation. Many of these are at the limits of disciplines that today are contiguous, and had, until a short time ago, been separated by distances that were more apparent than substantial, in the tumultuous implementation of the models designed to explain the technologies.

Published
2009

37. Archetipi e doni del selvaggio

Author

PIERINI, GIOVANNI, BALBI, TIZIANA, G. GOLINELLI, G Pierini, and T Balbi

Subjects
FILOSOFIA DELLA MEDICINA, PRIMITIVISMO
Abstract

la nascita del pensiero scientifico al termine dell'epoca della medicina magico-teurgica

Published
2007

39. Mo2046 - Eicosapentaenoic Acid-Free Fatty Reduces Fecal Calprotectin Levels and Affects Colitis-Associated Colorectal Cancer Pathways in Patients with Long-Standing Ulcerative Colitis

Author

Prossomariti, Anna, Scaioli, Eleonora, Piazzi, Giulia, Fazio, Chiara, Bellanova, Matteo, Biagi, Elena, Candela, Marco, Brigidi, Patrizia, Consolandi, Clarissa, Balbi, Tiziana, Chieco, Pasquale, Munarini, Alessandra, Pariali, Milena, Minguzzi, Manuela, Bazzoli, Franco, Belluzzi, Andrea, and Ricciardiello, Luigi

Published
2017
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41. Evaluation of reliability of STR typing in different types of cancerous tissues used for identification purpose

Author

CECCARDI, STEFANIA, M. Alù, LUGARESI, FEDERICA, FERRI, GIANMARCO, BINI, CARLA, BALBI, TIZIANA, INGRAVALLO, FRANCESCA, PELOTTI, SUSI, ANTONIO AMORIM FRANCISCO CORTE-REAL NIELS MORLING, S. Ceccardi, M. Alù, F. Lugaresi, G. Ferri, C. Bini, T. Balbi, F. Ingravallo, and S. Pelotti.

Subjects
MICROSATELLITE INSTABILITY, CANCEROUS TISSUE, LOSS OF HETEROZYGOSITY, DNA, STR
Abstract

In this study we screened 48 gastrointestinal carcinomas, 13 urogenital and 7 oral carcinomas in parallel with control samples for the 15 STR loci of the AmpFlSTR Identifiler Kit to provide further data useful to evaluate the applicability on cancerous tissues of STRs used in forensic field. A total of 37 cancerous tissues (54.4%) showed allelic alterations when compared with the corresponding normal tissues: 29 (78.4%) gastrointestinal tumors, 4 (10.8%) urogenital tumors and 4 (10.8%) oral tumors. The loci most frequently affected by allelic alterations were VWA, FGA and D18S51. These results suggest that great care should be taken in the evaluation of the DNA typing results obtained from clinical cancerous specimens when no other reference samples containing normal tissue are available.

Published
2006

42. STR typing of cancerous tissues for identification purpose

Author

CECCARDI, STEFANIA, LUGARESI, FEDERICA, BALBI, TIZIANA, INGRAVALLO, FRANCESCA, FERRI, GIANMARCO, BINI, CARLA, PELOTTI, SUSI, A. Conconi, S. Ceccardi, F. Lugaresi, T. Balbi, A. Conconi, F. Ingravallo, G. Ferri, C. Bini, and S. Pelotti

Published
2005

43. Somatic APCmosaicism and oligogenic inheritance in genetically unsolved colorectal adenomatous polyposis patients

Author

Ciavarella, Michele, Miccoli, Sara, Prossomariti, Anna, Pippucci, Tommaso, Bonora, Elena, Buscherini, Francesco, Palombo, Flavia, Zuntini, Roberta, Balbi, Tiziana, Ceccarelli, Claudio, Bazzoli, Franco, Ricciardiello, Luigi, Turchetti, Daniela, and Piazzi, Giulia

Abstract

Germline variants in the APCgene cause familial adenomatous polyposis. Inherited variants in MutYH, POLE, POLD1, NTHL1, and MSH3genes and somatic APCmosaicism have been reported as alternative causes of polyposis. However, ~30–50% of cases of polyposis remain genetically unsolved. Thus, the aim of this study was to investigate the genetic causes of unexplained adenomatous polyposis. Eight sporadic cases with >20 adenomatous polyps by 35 years of age or >50 adenomatous polyps by 55 years of age, and no causative germline variants in APCand/or MutYH, were enrolled from a cohort of 56 subjects with adenomatous colorectal polyposis. APCgene mosaicism was investigated on DNA from colonic adenomas by Sanger sequencing or Whole Exome Sequencing (WES). Mosaicism extension to other tissues (peripheral blood, saliva, hair follicles) was evaluated using Sanger sequencing and/or digital PCR. APCsecond hit was investigated in adenomas from mosaic patients. WES was performed on DNA from peripheral blood to identify additional polyposis candidate variants. We identified APCmosaicism in 50% of patients. In three cases mosaicism was restricted to the colon, while in one it also extended to the duodenum and saliva. One patient without APCmosaicism, carrying an APCin-frame deletion of uncertain significance, was found to harbor rare germline variants in OGG1, POLQ, and EXO1genes. In conclusion, our restrictive selection criteria improved the detection of mosaic APCpatients. In addition, we showed for the first time that an oligogenic inheritance of rare variants might have a cooperative role in sporadic colorectal polyposis onset.

Published
2018
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50. GABA and glutamate in migraine

Author

D'Andrea, Giovanni, Granella, Franco, Cataldini, Morena, Verdelli, Flavio, and Balbi, Tiziana

Subjects
Migraine -- Causes of, Migraine -- Research, GABA -- Research, Glutamate -- Research, Health
Abstract

Byline: Giovanni D'Andrea (1), Franco Granella (2), Morena Cataldini (3), Flavio Verdelli (1), Tiziana Balbi (1) Keywords: Key words GABA; Glutamic acid; Migraine with and without aura; Migraine pathogenesis Abstract: GABA and glutamic acid are the main inhibitory and excitatory neurotransmitters of central nervous system. Among other functions they modulate the pain threshold in the CNS. For this reason it has been hypothesized that anomalies of GABA and glutamate turn-over may play a role in migraine pathogenesis. In this review are discussed the evidences in favour of this hypothesis. A derangement of GABA may be an important factor in the occurrence of migraine attacks and their recurrence, whereas high level of glutamic acid may represent a biochemical marker of the neuronal hyperexcitability that may be the underlying cause of the aura. The pharmacological modulation of metabolism of both neurotransmitters is a promising approach to improve migraine therapy. In particular the studies presented here suggest that gabaergic drugs may be useful in migraine without aura, antiglutamatergic drugs are indicated to treat migraine with aura. Author Affiliation: (1) Headache and Related Disorders Center, Pathology Unit, Este-Monselice Hospital, Este-Monselice (PD), Italy, e-mail: giovinavi@libero.it, Tel.: +39-0429-618421, Fax: +39-0429-618532, IT (2) Institute of Neurology, University of Parma, Parma, Italy, IT (3) Department of Neurology, Este-Monselice Hospital, Este-Monselice (PD), Italy, IT

Published
2001

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